1. Experimental toothpastes containing β-TCP nanoparticles functionalized with fluoride and tin to prevent Erosive Tooth Wear.
- Author
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Weiss GS, Silva FRO, Garcia RM, Sakae LO, Viana ÍEL, Hara AT, Lima LC, and Scaramucci T
- Subjects
- Hydrogen-Ion Concentration, Tin Compounds therapeutic use, Tin Compounds chemistry, Sodium Fluoride therapeutic use, Sodium Fluoride chemistry, Animals, Fluorides therapeutic use, Tin chemistry, Tooth Abrasion prevention & control, Cattle, Materials Testing, Surface Properties, Random Allocation, Toothbrushing, Humans, Calcium Phosphates chemistry, Calcium Phosphates therapeutic use, Toothpastes chemistry, Toothpastes therapeutic use, Tooth Erosion prevention & control, Nanoparticles chemistry, Dental Enamel drug effects
- Abstract
Objectives: The present study aimed to synthesize toothpastes containing Beta- TriCalcium Phosphate (β-TCP) nanoparticles, functionalized with fluoride and tin, and test their ability to reduce erosive tooth wear (ETW)., Methods: Toothpastes were synthesized with the following active ingredients: 1100 ppm of fluoride (as sodium fluoride, F
- ), 3500 ppm of tin (as stannous chloride, Sn2+ ), and 800 ppm of β-TCP (Sizes a - 20 nm; and b - 100 nm). Enamel specimens were randomly assigned into the following groups (n = 10): 1. Commercial toothpaste; 2. Placebo; 3 F- ; 4. F- + β-TCPa ; 5. F- + β-TCPb ; 6. F- + Sn2+ ; 7. F- + Sn2+ + β-TCPa and 8. F- + Sn2+ + β-TCPb . Specimens were subjected to erosion-abrasion cycling. Surface loss (in µm) was measured by optical profilometry. Toothpastes pH and available F- were also assessed., Results: Brushing with placebo toothpaste resulted in higher surface loss than brushing with F- (p = 0.005) and F- + β-TCPb (p = 0.007); however, there was no difference between F- and F- + β-TCPb (p = 1.00). Commercial toothpaste showed no difference from Placebo (p = 0.279). The groups F- , F- + β-TCPa , F- + β-TCPb , F- + Sn2+ , F- + Sn2+ + β-TCPa and F- + Sn2+ + β-TCPb were not different from the commercial toothpaste (p > 0.05). Overall, the addition of β-TCP reduced the amount of available fluoride in the experimental toothpastes. The pH of toothpastes ranged from 4.97 to 6.49., Conclusions: Although toothpaste containing β-TCP nanoparticles protected enamel against dental erosion-abrasion, this effect was not superior to the standard fluoride toothpaste (commercial). In addition, the functionalization of β-TCP nanoparticles with fluoride and tin did not enhance their protective effect., Clinical Significance: Although β-TCP nanoparticles have some potential to control Erosive Tooth Wear, their incorporation into an experimental toothpaste appears to have a protective effect that is similar to a commercial fluoride toothpaste., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)- Published
- 2024
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