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1. The Multidimensional Prognostic Index predicts incident delirium among hospitalized older patients with COVID-19: a multicenter prospective European study

Author

Morganti, Wanda, Custodero, Carlo, Veronese, Nicola, Topinkova, Eva, Michalkova, Helena, Polidori, M. Cristina, Cruz‐Jentoft, Alfonso J., von Arnim, Christine A. F., Azzini, Margherita, Gruner, Heidi, Castagna, Alberto, Cenderello, Giovanni, Custureri, Romina, Seminerio, Emanuele, Zieschang, Tania, Padovani, Alessandro, Sanchez‐Garcia, Elisabet, and Pilotto, Alberto

Published
2024
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3. The Role of Multidimensional Prognostic Index to Identify Hospitalized Older Adults with COVID-19 Who Can Benefit from Remdesivir Treatment: An Observational, Prospective, Multicenter Study

Author

Custodero, Carlo, Veronese, Nicola, Topinkova, Eva, Michalkova, Helena, Polidori, Maria Cristina, Cella, Alberto, Cruz-Jentoft, Alfonso J., von Arnim, Christine A. F., Azzini, Margherita, Gruner, Heidi, Castagna, Alberto, Cenderello, Giovanni, Custureri, Romina, Zieschang, Tania, Padovani, Alessandro, Sanchez-Garcia, Elisabet, and Pilotto, Alberto

Published
2023
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5. Quality of life in sarcopenia measured with the SarQoL questionnaire: A meta-analysis of individual patient data

Author

Beaudart, Charlotte, Tilquin, Noémie, Abramowicz, Pawel, Baptista, Fátima, Peng, Dao Juan, de Souza Orlandi, Fabiana, Drey, Michael, Dzhus, Marta, Fábrega-Cuadros, Raquel, Fernandez-Garrido, Julio, Laurindo, Lucas Fornari, Gasparik, Andrea-Ildiko, Geerinck, Anton, Emin, Gyulnaz, Iacob, Speranta, Kilaitė, Justina, Kumar, Prabal, Lee, Shu-Chun, Lou, Vivian W.Q., Mahmoodi, Marzieh, Matijevic, Radmila, Matveeva, Mariia V., Merle, Blandine, Montero-Errasquín, Beatriz, Bhattoa, Harjit Pal, Safonova, Yuliya, Şimşek, Hilal, Topinkova, Eva, Tsekoura, Maria, Erdoğan, Tuğba, Yoo, Jun-Il, Yu, Ruby, Hiligsmann, Mickael, Reginster, Jean-Yves, and Bruyère, Olivier

Published
2024
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7. Sarcopenic obesity research perspectives outlined by the sarcopenic obesity global leadership initiative (SOGLI) – Proceedings from the SOGLI consortium meeting in Rome November 2022

Author

Bosy-Westphal, Anja, Brunani, Amelia, Capodaglio, Paolo, Coletti, Dario, Ferretti, Elisabetta, Frigerio, Francesco, Giustina, Andrea, Lenzi, Andrea, Marini, Elisabetta, Migliaccio, Silvia, Minnetti, Marianna, Mocini, Edoardo, Moro, Tatiana, Muscaritoli, Maurizio, Noirez, Philippe, Paoli, Antonio, Rondanelli, Mariangela, Rughetti, Auralia, Schoufour, Josje D., Skalska, Anna, Topinkova, Eva, Wakabayashi, Hidekata, Yu, Jianchun, Gortan Cappellari, Gianluca, Guillet, Christelle, Poggiogalle, Eleonora, Ballesteros Pomar, Maria D., Batsis, John A., Boirie, Yves, Breton, Irene, Frara, Stefano, Genton, Laurence, Gepner, Yftach, Gonzalez, Maria Cristina, Heymsfield, Steven B., Kiesswetter, Eva, Laviano, Alessandro, Prado, Carla M., Santini, Ferruccio, Serlie, Mireille J., Siervo, Mario, Villareal, Dennis T., Volkert, Dorothee, Voortman, Trudy, Weijs, Peter JM., Zamboni, Mauro, Bischoff, Stephan C., Busetto, Luca, Cederholm, Tommy, Barazzoni, Rocco, and Donini, Lorenzo M.

Published
2023
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8. Barriers and facilitators in using a Clinical Decision Support System for fall risk management for older people: a European survey

Author

Ploegmakers, Kim J., Medlock, Stephanie, Linn, Annemiek J., Lin, Yumin, Seppälä, Lotta J., Petrovic, Mirko, Topinkova, Eva, Ryg, Jesper, Mora, Maria Angeles Caballero, Landi, Francesco, Thaler, Heinrich, Szczerbińska, Katarzyna, Hartikainen, Sirpa, Bahat, Gulistan, Ilhan, Birkan, Morrissey, Yvonne, Masud, Tahir, van der Velde, Nathalie, and van Weert, Julia C. M.

Published
2022
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10. Sarcopenia and Sarcopenic Obesity and Mortality Among Older People

Author

Benz, Elizabeth, Pinel, Alexandre, Guillet, Christelle, Capel, Frederic, Pereira, Bruno, De Antonio, Marie, Pouget, Melanie, Cruz-Jentoft, Alfonso J., Eglseer, Doris, Topinkova, Eva, Barazzoni, Rocco, Rivadeneira, Fernando, Ikram, M. Arfan, Steur, Marinka, Voortman, Trudy, Schoufour, Josje D., Weijs, Peter J.M., Boirie, Yves, Benz, Elizabeth, Pinel, Alexandre, Guillet, Christelle, Capel, Frederic, Pereira, Bruno, De Antonio, Marie, Pouget, Melanie, Cruz-Jentoft, Alfonso J., Eglseer, Doris, Topinkova, Eva, Barazzoni, Rocco, Rivadeneira, Fernando, Ikram, M. Arfan, Steur, Marinka, Voortman, Trudy, Schoufour, Josje D., Weijs, Peter J.M., and Boirie, Yves

Abstract

Importance: Sarcopenia and obesity are 2 global concerns associated with adverse health outcomes in older people. Evidence on the population-based prevalence of the combination of sarcopenia with obesity (sarcopenic obesity [SO]) and its association with mortality are still limited. Objective: To investigate the prevalence of sarcopenia and SO and their association with all-cause mortality. Design, Setting, and Participants: This large-scale, population-based cohort study assessed participants from the Rotterdam Study from March 1, 2009, to June 1, 2014. Associations of sarcopenia and SO with all-cause mortality were studied using Kaplan-Meier curves, Cox proportional hazards regression, and accelerated failure time models fitted for sex, age, and body mass index (BMI). Data analysis was performed from January 1 to April 1, 2023. Exposures: The prevalence of sarcopenia and SO, measured based on handgrip strength and body composition (BC) (dual-energy x-ray absorptiometry) as recommended by current consensus criteria, with probable sarcopenia defined as having low handgrip strength and confirmed sarcopenia and SO defined as altered BC (high fat percentage and/or low appendicular skeletal muscle index) in addition to low handgrip strength. Main Outcome and Measure: The primary outcome was all-cause mortality, collected using linked mortality data from general practitioners and the central municipal records, until October 2022. Results: In the total population of 5888 participants (mean [SD] age, 69.5 [9.1] years; mean [SD] BMI, 27.5 [4.3]; 3343 [56.8%] female), 653 (11.1%; 95% CI, 10.3%-11.9%) had probable sarcopenia and 127 (2.2%; 95% CI, 1.8%-2.6%) had confirmed sarcopenia. Sarcopenic obesity with 1 altered component of BC was present in 295 participants (5.0%; 95% CI, 4.4%-5.6%) and with 2 altered components in 44 participants (0.8%; 95% CI, 0.6%-1.0%). An increased risk of all-cause mortality was observed in participants with probable sarcopenia (hazard ratio [

Published
2024

12. Can the Multidimensional Prognostic Index Improve the Identification of Older Hospitalized Patients with COVID-19 Likely to Benefit from Mechanical Ventilation? An Observational, Prospective, Multicenter Study

Author

Barbagallo, Mario, Dini, Simone, Diesner, Naima Madlen, Fernandes, Marilia, Gandolfo, Federica, Garaboldi, Sara, Musacchio, Clarissa, Pilotto, Andrea, Pickert, Lena, Podestà, Silvia, Ruotolo, Giovanni, Sciolè, Katiuscia, Schlotmann, Julia, Pilotto, Alberto, Topinkova, Eva, Michalkova, Helena, Polidori, Maria Cristina, Cella, Alberto, Cruz-Jentoft, Alfonso, von Arnim, Christine A.F., Azzini, Margherita, Gruner, Heidi, Castagna, Alberto, Cenderello, Giovanni, Custureri, Romina, Custodero, Carlo, Zieschang, Tania, Padovani, Alessandro, Sanchez-Garcia, Elisabet, and Veronese, Nicola

Published
2022
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14. Association of Antidementia Drugs and Mortality in Community-Dwelling Frail Older Patients With Dementia: The Role of Mortality Risk Assessment

Author

Cruz-Jentoft, Alfonso, Durando, Mario, Ferrucci, Luigi, Fratiglioni, Laura, Mattace-Raso, Francesco, Paccalin, Marc, Ruppe, Georg, Schulz, Ralf-Joachim, Topinkova, Eva, Trifirò, Gianluca, Welmer, Anna-Karin, Pilotto, Alberto, Polidori, Maria Cristina, Veronese, Nicola, Panza, Francesco, Arboretti Giancristofaro, Rosa, Pilotto, Andrea, Daragjati, Julia, Carrozzo, Eleonora, Prete, Camilla, Gallina, Pietro, Padovani, Alessandro, and Maggi, Stefania

Published
2018
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15. Association of polypharmacy and hyperpolypharmacy with frailty states: a systematic review and meta-analysis

Author

Palmer, Katie, Villani, Emanuele R., Vetrano, Davide L., Cherubini, Antonio, Cruz-Jentoft, Alfonso J., Curtin, Denis, Denkinger, Michael, Gutiérrez-Valencia, Marta, Guðmundsson, Adalsteinn, Knol, Wilma, Mak, Diane V., O’Mahony, Denis, Pazan, Farhad, Petrovic, Mirko, Rajkumar, Chakravarthi, Topinkova, Eva, Trevisan, Catarina, van der Cammen, Tischa J. M., van Marum, Rob J., Wehling, Martin, Ziere, Gijsbertus, Bernabei, Roberto, Onder, Graziano, and On behalf of the European Geriatric Medicine Society Pharmacology special interest group

Published
2019
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16. eHealth in Geriatric Rehabilitation: An International Survey of the Experiences and Needs of Healthcare Professionals

Author

Kraaijkamp, Jules J. M., primary, Persoon, Anke, additional, Aurelian, Sorina, additional, Bachmann, Stefan, additional, Cameron, Ian D., additional, Choukou, Mohamed-Amine, additional, Dockery, Frances, additional, Eruslanova, Kseniia, additional, Gordon, Adam L., additional, Grund, Stefan, additional, Kim, Hyub, additional, Maier, Andrea B., additional, Pérez Bazan, Laura M., additional, Pompeu, José E., additional, Topinkova, Eva, additional, Vassallo, Mark A., additional, Chavannes, Niels H., additional, Achterberg, Wilco P., additional, and Van Dam van Isselt, Eléonore F., additional

Published
2023
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17. Using a multidimensional prognostic index (MPI) based on comprehensive geriatric assessment (CGA) to predict mortality in elderly undergoing transcatheter aortic valve implantation

Author

Cruz-Jentoft, Alfonso, Maggi, Stefania, Mattace-Raso, Francesco, Paccalin, Marc, Polidori, Maria Cristina, Sancarlo, Daniele, Topinkova, Eva, Trifirò, Gianluca, Bureau, Marie-Laure, Liuu, Evelyne, Christiaens, Luc, Pilotto, Alberto, Mergy, Jean, Bellarbre, Fabienne, and Ingrand, Pierre

Published
2017
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22. The role of prognostic stratification on prescription of anticoagulants in older patients with atrial fibrillation : a multicenter, observational, prospective European study (EUROSAF)

Author

Pilotto, Alberto, Veronese, Nicola, Polidori, Maria Cristina, Strandberg, Timo, Topinkova, Eva, Cruz-Jentoft, Alfonso J., Custodero, Carlo, Maggi, Stefania, HUS Internal Medicine and Rehabilitation, Timo Strandberg / Principal Investigator, Department of Medicine, Clinicum, University of Helsinki, Pilotto, Alberto, Veronese, Nicola, Polidori, Maria Cristina, Strandberg, Timo, Topinkova, Eva, Cruz-Jentoft, Alfonso J, Custodero, Carlo, and Maggi, Stefania

Subjects
EUROSAF, anticoagulants, comprehensive geriatric assessment, frailty, multidimensional prognostic index, older people, Administration, Oral, VALIDATION, Risk Factors, Atrial Fibrillation, Humans, Prospective Studies, ELDERLY-PATIENTS, INDEX, Aged, Aged, 80 and over, MORTALITY, General Medicine, ADULTS, Prognosis, Cross-Sectional Studies, Prescriptions, 3121 General medicine, internal medicine and other clinical medicine, Female, EUROSAF, anticoagulants, comprehensive geriatric assessment, frailty, multidimensional prognostic index, older people, STROKE
Abstract

Background: Literature suggests that different risks of mortality could influence physicians in prescribing or not anticoagulants in older patients with atrial fibrillation (AF). The Multidimensional Prognostic Index (MPI) can be considered a tool for the detection of multidimensional frailty. The aim of this cross-sectional study was to evaluate whether prescription patterns of oral anticoagulants exist, based on MPI values. Methods: Older hospitalised patients (age >= 65 years) with non-valvular AF were included across 24 European centres. MPI was calculated using validated and standardised tools derived from a comprehensive geriatric assessment. Other functional and clinical information were collected to calculate indexes specific for haemorrhagic and thromboembolic risk in AF. Results: Altogether, 2,012 participants affected by AF (mean age was 83.2 +/- 7.5, range: 65-104 years), with a higher presence of women (57.0%), were included. Overall, 440 took vitamin K antagonists VKAs (22.0%), 667 (33.4%) direct oral anticoagulants (DOACs), whilst 44.6% did not take any anticoagulant treatment. Prescription of anticoagulants was associated with MPI values, with people taking anticoagulants having lower mean MPI values. Anticoagulant therapy was not used in 53.1% of the group with the highest risk of mortality, compared with 32.3% of those in the group with the lowest mortality risk. People with higher scores in MPI were less frequently treated with anticoagulant therapy, after adjusting for several potential confounders. Conclusions: The EURopean study of Older Subjects with Atrial Fibrillation (EUROSAF) suggested that almost half of the older persons with AF do not receive anticoagulants and that MPI is an important determinant in prescribing or not anticoagulants.

Published
2022

23. Frailty and anticoagulants in older subjects with atrial fibrillation: the EUROSAF study.

Author

Pilotto, Alberto, Veronese, Nicola, Polidori, Maria Cristina, Strandberg, Timo, Topinkova, Eva, Cruz-Jentoft, Alfonso J, Custodero, Carlo, Barbagallo, Mario, Maggi, Stefania, and Investigators, the EUROSAF Study

Subjects
MORTALITY prevention, THROMBOEMBOLISM prevention, DRUG efficacy, RESEARCH, FRAIL elderly, HEMORRHAGIC stroke, CONFIDENCE intervals, SCIENTIFIC observation, MYOCARDIAL ischemia, ISCHEMIC stroke, GASTROINTESTINAL hemorrhage, ORAL drug administration, ANTICOAGULANTS, ATRIAL fibrillation, ACQUISITION of data, GERIATRIC assessment, SEVERITY of illness index, COMPARATIVE studies, HOSPITAL care of older people, RESEARCH funding, MEDICAL records, DESCRIPTIVE statistics, LONGITUDINAL method, VITAMIN K, CHEMICAL inhibitors, DISEASE risk factors, EVALUATION, OLD age
Abstract

Aims Literature regarding anticoagulants in older people affected by atrial fibrillation (AF) is limited to retrospective studies, poorly considering the importance of multidimensional frailty. The main objective of this study is to evaluate in hospitalised older persons with AF the benefit/risk ratio of the anticoagulant treatments, considering the severity of frailty, determined by the multidimensional prognostic index (MPI). Methods In this European, multicentre, prospective study, older hospitalised patients (≥65 years) with non-valvular AF were followed-up for 12 months. Anticoagulants' use at discharge ascertained using medical records. MPI was calculated using tools derived from comprehensive geriatric assessment, classifying participants in robust, pre-frail or frail. Mortality (primary outcome); vascular events, including ischemic heart disease or ischemic stroke, hemorrhagic stroke or gastrointestinal bleedings (secondary outcomes). Results 2,022 participants (mean age 82.9 years; females 56.6%) were included. Compared with people not taking anticoagulants (n  = 823), people using vitamin K antagonists (n  = 450) showed a decreased risk of mortality (hazard ratio, HR = 0.74; 95% CI: 0.59–0.93), more pronounced in patients using direct oral anticoagulants (DOACs) (n  = 749) (HR = 0.46; 95% CI: 0.37–0.57). Only people taking DOACs reported a significantly lower risk of vascular events (HR = 0.55; 95% CI: 0.31–0.97). The efficacy of DOACs was present independently from frailty status. The risk of gastrointestinal bleedings and hemorrhagic stroke did not differ based on the anticoagulant treatments and by MPI values. Conclusions Anticoagulant treatment, particularly with DOACs, was associated with reduced mortality in older people, without increasing the risk of hemorrhagic events, overall suggesting the importance of treating with anticoagulants older people with AF. [ABSTRACT FROM AUTHOR]

Published
2023
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24. Sarcopenic obesity research perspectives outlined by the sarcopenic obesity global leadership initiative (SOGLI) – Proceedings from the SOGLI consortium meeting in rome November 2022

Author

Gortan Cappellari, Gianluca, primary, Guillet, Christelle, additional, Poggiogalle, Eleonora, additional, Ballesteros Pomar, Maria D., additional, Batsis, John A., additional, Boirie, Yves, additional, Breton, Irene, additional, Frara, Stefano, additional, Genton, Laurence, additional, Gepner, Yftach, additional, Gonzalez, Maria Cristina, additional, Heymsfield, Steven B., additional, Kiesswetter, Eva, additional, Laviano, Alessandro, additional, Prado, Carla M., additional, Santini, Ferruccio, additional, Serlie, Mireille J., additional, Siervo, Mario, additional, Villareal, Dennis T., additional, Volkert, Dorothee, additional, Voortman, Trudy, additional, Weijs, Peter JM., additional, Zamboni, Mauro, additional, Bischoff, Stephan C., additional, Busetto, Luca, additional, Cederholm, Tommy, additional, Barazzoni, Rocco, additional, Donini, Lorenzo M., additional, Bosy-Westphal, Anja, additional, Brunani, Amelia, additional, Capodaglio, Paolo, additional, Coletti, Dario, additional, Ferretti, Elisabetta, additional, Frigerio, Francesco, additional, Giustina, Andrea, additional, Lenzi, Andrea, additional, Marini, Elisabetta, additional, Migliaccio, Silvia, additional, Minnetti, Marianna, additional, Mocini, Edoardo, additional, Moro, Tatiana, additional, Muscaritoli, Maurizio, additional, Noirez, Philippe, additional, Paoli, Antonio, additional, Rondanelli, Mariangela, additional, Rughetti, Auralia, additional, Schoufour, Josje D., additional, Skalska, Anna, additional, Topinkova, Eva, additional, Wakabayashi, Hidekata, additional, and Yu, Jianchun, additional

Published
2023
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27. interRAI för Sarskilt Boende (Long-Term Care Facilities, LTCF) Bedömningsformular och Anvandarmanual, Version 10.0, Svensk utgava

Author

Morris, John N., Hackman, George, Berg, Katherine, Björkgren, Magnus, Costa, Andrew P., Declercq, Anja, Finne-Soveri, Ulla Harriet, Fries, Brant E., Frijters, Dinnus, Gray, Len, Head, Michael J., Henrard, Jean-Claude, Hirdes, John P., James, Mary L., Ljunggren, Gunnar, Meehan, Brigette, Steward, Shannon L., Szczerbińska, Katarzyna, and Topinkova, Eva

Published
2023

28. eHealth in Geriatric Rehabilitation: An International Survey of the Experiences and Needs of Healthcare Professionals

Author

Kraaijkamp, Jules J M, Persoon, Anke, Aurelian, Sorina, Bachmann, Stefan, Cameron, Ian D, Choukou, Mohamed-Amine, Dockery, Frances, Eruslanova, Kseniia, Gordon, Adam L, Grund, Stefan, Kim, Hyub, Maier, Andrea B, Pérez Bazan, Laura M, Pompeu, José E, Topinkova, Eva, Vassallo, Mark A, Chavannes, Niels H, Achterberg, Wilco P, and Van Dam van Isselt, Eléonore F

Subjects
610 Medicine & health
Abstract

While eHealth can help improve outcomes for older patients receiving geriatric rehabilitation, the implementation and integration of eHealth is often complex and time-consuming. To use eHealth effectively in geriatric rehabilitation, it is essential to understand the experiences and needs of healthcare professionals. In this international multicentre cross-sectional study, we used a web-based survey to explore the use, benefits, feasibility and usability of eHealth in geriatric rehabilitation settings, together with the needs of working healthcare professionals. Descriptive statistics were used to summarize quantitative findings. The survey was completed by 513 healthcare professionals from 16 countries. Over half had experience with eHealth, although very few (52 of 263 = 20%) integrated eHealth into daily practice. Important barriers to the use or implementation of eHealth included insufficient resources, lack of an organization-wide implementation strategy and lack of knowledge. Professionals felt that eHealth is more complex for patients than for themselves, and also expressed a need for reliable information concerning available eHealth interventions and their applications. While eHealth has clear benefits, important barriers hinder successful implementation and integration into healthcare. Tailored implementation strategies and reliable information on effective eHealth applications are needed to overcome these barriers.

Published
2023
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29. The “Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies” (SPRINTT) randomized controlled trial: design and methods

Author

Landi, Francesco, Cesari, Matteo, Calvani, Riccardo, Cherubini, Antonio, Di Bari, Mauro, Bejuit, Raphael, Mshid, Jerome, Andrieu, Sandrine, Sinclair, Alan J., Sieber, Cornel C., Vellas, Bruno, Topinkova, Eva, Strandberg, Timo, Rodriguez-Manas, Leocadio, Lattanzio, Fabrizia, Pahor, Marco, Roubenoff, Ronenn, Cruz-Jentoft, Alfonso J., Bernabei, Roberto, Marzetti, Emanuele, and on behalf of the SPRINTT Consortium

Published
2017
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34. Priority topics for European multidisciplinary guidelines on the management of chronic kidney disease in older adults

Author

van der Veer, Sabine N., van Biesen, Wim, Bernaert, Pascale, Bolignano, Davide, Brown, Edwina A., Covic, Adrian, Farrington, Ken, Jager, Kitty J., Kooman, Jeroen, Macías-Núñez, Juan F., Mooney, Andrew, van Munster, Barbara C., Topinkova, Eva, Van Den Noortgate, Nele J. A., Wirnsberger, Gerhard, Michel, Jean-Pierre, and Nistor, Ionut

Published
2016
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35. Can the Multidimensional Prognostic Index Improve the Identification of Older Hospitalized Patients with COVID-19 Likely to Benefit from Mechanical Ventilation? An Observational, Prospective, Multicenter Study

Author

Pilotto, Alberto, primary, Topinkova, Eva, additional, Michalkova, Helena, additional, Polidori, Maria Cristina, additional, Cella, Alberto, additional, Cruz-Jentoft, Alfonso, additional, von Arnim, Christine A.F., additional, Azzini, Margherita, additional, Gruner, Heidi, additional, Castagna, Alberto, additional, Cenderello, Giovanni, additional, Custureri, Romina, additional, Custodero, Carlo, additional, Zieschang, Tania, additional, Padovani, Alessandro, additional, Sanchez-Garcia, Elisabet, additional, Veronese, Nicola, additional, Barbagallo, Mario, additional, Dini, Simone, additional, Diesner, Naima Madlen, additional, Fernandes, Marilia, additional, Gandolfo, Federica, additional, Garaboldi, Sara, additional, Musacchio, Clarissa, additional, Pilotto, Andrea, additional, Pickert, Lena, additional, Podestà, Silvia, additional, Ruotolo, Giovanni, additional, Sciolè, Katiuscia, additional, and Schlotmann, Julia, additional

Published
2022
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39. Can the Multidimensional Prognostic Index Improve the Identification of Older Hospitalized Patients with COVID-19 Likely to Benefit from Mechanical Ventilation? An Observational, Prospective, Multicenter Study

Author

Pilotto, Alberto, Topinkova, Eva, Michalkova, Helena, Polidori, Maria Cristina, Cella, Alberto, Cruz-Jentoft, Alfonso, von Arnim, Christine A. F., Azzini, Margherita, Gruner, Heidi, Castagna, Alberto, Cenderello, Giovanni, Custureri, Romina, Custodero, Carlo, Zieschang, Tania, Padovani, Alessandro, Sanchez-Garcia, Elisabet, Veronese, Nicola, Pilotto, Alberto, Topinkova, Eva, Michalkova, Helena, Polidori, Maria Cristina, Cella, Alberto, Cruz-Jentoft, Alfonso, von Arnim, Christine A. F., Azzini, Margherita, Gruner, Heidi, Castagna, Alberto, Cenderello, Giovanni, Custureri, Romina, Custodero, Carlo, Zieschang, Tania, Padovani, Alessandro, Sanchez-Garcia, Elisabet, and Veronese, Nicola

Abstract

Objective: Data on prognostic tools for indicating mechanical ventilation in older people with COVID-19 are still limited. The aim of this research was to evaluate if the Multidimensional Prognostic Index (MPI), based on the Comprehensive Geriatric Assessment (CGA), may help physicians in identifying older hospitalized patients affected by COVID-19 who might benefit from mechanical ventilation. Design: Longitudinal, multicenter study. Settings and Participants: 502 older people hospitalized for COVID-19 in 10 European hospitals. Methods: MPI was calculated using 8 different domains typical of the CGA. A propensity score, Cox's regression analysis was used for assessing the impact of mechanical ventilation on rehospitalization/mortality for 90 days' follow-up, stratified by MPI = 0.50. The accuracy of MPI in predicting negative outcomes (ie, rehospitalization/mortality) was assessed using the area under the curve (AUC), and the discrimination with several indexes like the Net Reclassification Improvement (NRI) and the Integrated Discrimination Improvement (IDI). Results: Among 502 older people hospitalized for COVID-19 (mean age: 80 years), 152 were treated with mechanical ventilation. In the propensity score analysis, during the 90-day follow-up period, there were 44 rehospitalizations and 95 deaths. Mechanical ventilation in patients with MPI values >= 0.50, indicating frailer participants, was associated with a higher risk of rehospitalization/mortality (hazard ratio 1.56, 95% CI 1.09-2.23), whereas in participants with MPI values < 0.50 this association was not significant. The accuracy of the model including age, sex, respiratory parameters, and MPI was good (AUC = 0.783) as confirmed by an NRI of 0.2756 (P < .001) and an IDI of 0.1858 (P < .001), suggesting a good discrimination of the model in predicting negative outcomes. Conclusions and Implications: MPI could be useful for better individualizing older people hospitalized by COVID-19 who could benefit from m

Published
2022

45. Evaluating the effectiveness and risks of oral anticoagulant treatments in multimorbid frail older subjects with atrial fibrillation using the multidimensional prognostic index

Author

Veronese, Nicola, Argusti, Alessandra, Canepa, Elisabetta, Polidori, Maria Cristina, Maggi, Stefania, Strandberg, Timo, Pilotto, Alberto, Marchionni, Nicolò, Durando, Mario, Ferrara, Nicola, Bò, Mario, Barbagallo, Mario, Ruotolo, Giovanni, Heppner, Hans Jurgen, Bahrmann, Philipp, Roller-Wirnsberger, Regina, Pedro, Gil Gregorio, Cruz-Jentoft, Alfonso, da Silva, Pedro Marques, Gruner, Heidi, Berg, Nicolas, Topinkova, Eva, Matejovska-Kubesova, Hana, Nieminen, Tuomo, Pikkarainen, Laura, Rossinen, Juhani, Kearney-Schwartz, Anna, Rewiuk, Krzyszof, Mattace-Raso, Francesco, Olexa, Peter, Internal Medicine, Veronese, Nicola, Argusti, Alessandra, Canepa, Elisabetta, Polidori, Maria Cristina, Maggi, Stefania, Strandberg, Timo, Pilotto, Alberto, Marchionni, Nicolò, Durando, Mario, Ferrara, Nicola, Bò, Mario, Barbagallo, Mario, Ruotolo, Giovanni, Heppner, Hans Jurgen, Bahrmann, Philipp, Roller-Wirnsberger, Regina, Pedro, Gil Gregorio, Cruz-Jentoft, Alfonso, da Silva, Pedro Marque, Gruner, Heidi, Berg, Nicola, Topinkova, Eva, Matejovska-Kubesova, Hana, Nieminen, Tuomo, Pikkarainen, Laura, Rossinen, Juhani, Kearney-Schwartz, Anna, Rewiuk, Krzyszof, Mattace-Raso, Francesco, and Olexa, Peter

Subjects
medicine.medical_specialty, Muldimensional Prognostic Index, Population, law.invention, 03 medical and health sciences, Elderly, 0302 clinical medicine, Randomized controlled trial, law, Internal medicine, Atrial Fibrillation, medicine, Risk of mortality, 030212 general & internal medicine, Medical prescription, education, Anticoagulants, Frailty, education.field_of_study, business.industry, Anticoagulant, Warfarin, Atrial fibrillation, medicine.disease, Relative risk, Observational study, Geriatrics and Gerontology, business, Gerontology, 030217 neurology & neurosurgery, medicine.drug
Abstract

Background: Previous studies suggested that a different risk of mortality may influence the oral anticoagulant prescription in older patients with atrial fibrillation (AF). Recently, the Multidimensional Prognostic Index (MPI) demonstrated a high grade of accuracy, calibration and feasibility to predict mortality in hospitalized and community-dwelling older people. Prognostic information, as calculated by the MPI, however, is not included in the decision algorithm of treatments in older patients with AF Purpose: The aim of this international multicenter prospective observational study was to evaluate whether a different prognostic profile, as determined by the MPI, is associated with different treatments for AF (no treatment vs oral anticoagulants) and differences in the main outcomes, i.e., mortality, major thromboembolic events and side effects. Materials and methods: Older hospitalized patients (age ≥ 65 years) with non-valvular AF will be consecutively enrolled in an European, cross-national, prospective, observational study. At baseline, functional and clinical information will be collected to calculate the MPI, CHA2DS2-VASc score, HAS-BLED score, pharmacological treatments (and the compliance during follow-up) and main and secondary diagnoses. During the 12-month follow-up period, information on survival, major thromboembolic events and major bleeding will be collected. For these aims, a sample size of 3000 people was deemed as sufficient. Conclusions: The EUROSAF study has the main objective of evaluating in a population of hospitalized older subjects with AF the clinical benefit/risk ratio of the oral anticoagulant treatments in terms of mortality, major thromboembolic events and bleeding side-effects, giving important information regarding the appropriate prescription of anticoagulant therapy in this population. ClinicalTrials.gov Identifier: NCT02973984.

Published
2018

46. Sarcopenia

Author

Cruz-jentoft, Alfonso J., Bahat, Gülistan, Bauer, Juergen, Boirie, Yves, Bruyère, Olivier, Cederholm, Tommy, Cooper, Cyrus, Landi, Francesco, Rolland, Yves, Sayer, Avan Aihie, Schneider, Stéphane M., Sieber, Cornel C., Topinkova, Eva, Vandewoude, Maurits, Visser, Marjolein, Zamboni, Mauro, Bautmans, Ivan, Baeyens, Jean Pierre, Cesari, Matteo, Cherubini, Antonio, Kanis, John, Maggio, Marcello, Martin, Finbarr, Michel, Jean Pierre, Pitkala, Kaisu, Reginster, Jean Yves, Rizzoli, René, Sanchez-Rodriguez, Dolores, Schols, Jos, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, RS: CAPHRI - R1 - Ageing and Long-Term Care, Health Services Research, RS: Academische Werkplaats Ouderenzorg, Family Medicine, University Management, Department of General Practice and Primary Health Care, HUS Helsinki and Uusimaa Hospital District, Teachers' Academy, Biology, Research in Geriatrics and Gerontology, Gerontology, Rehabilitation Research, Physical Medicine and Rehabilitation, Frailty in Ageing, Movement and Sport Sciences, Biomechanics, Writing Grp European Working Grp, and Extended Grp EWGSOP2

Subjects
Gerontology, Research design, Aging, Biomedical Research, Disease, EWGSOP2, older people, 0302 clinical medicine, Statistics, Health care, GAIT SPEED, Medicine, 030212 general & internal medicine, Medical diagnosis, ALL-CAUSE MORTALITY, Geriatrics, muscle assessment, Hand Strength, Public Health, Global Health, Social Medicine and Epidemiology, Skeletal, APPENDICULAR LEAN MASS, General Medicine, musculoskeletal system, 3. Good health, Europe, DWELLING OLDER-PEOPLE, Muscle, GRIP STRENGTH, Corrigendum, medicine.medical_specialty, Consensus, Geriatrik, OF-LIFE QUESTIONNAIRE, MEDLINE, Breast Neoplasms, Guidelines, Discount points, SKELETAL-MUSCLE MASS, sarcopenia, 03 medical and health sciences, SDG 3 - Good Health and Well-being, BIOELECTRICAL-IMPEDANCE ANALYSIS, muscle strength, physical performance, Biomarkers, Humans, Muscle Strength, Muscle, Skeletal, Sarcopenia, COMPUTED-TOMOGRAPHY, Sarcopenic obesity, ADIPOSE-TISSUE VOLUMES, business.industry, medicine.disease, body regions, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Ageing, LOWER-EXTREMITY FUNCTION, 3121 General medicine, internal medicine and other clinical medicine, Human medicine, Geriatrics and Gerontology, business, Value (mathematics), human activities, 030217 neurology & neurosurgery
Abstract

Correction: Volume: 48 Issue: 4 Article Number: UNSP 601 DOI: 10.1093/ageing/afz046 Background in 2010, the European Working Group on Sarcopenia in Older People (EWGSOP) published a sarcopenia definition that aimed to foster advances in identifying and caring for people with sarcopenia. In early 2018, the Working Group met again (EWGSOP2) to update the original definition in order to reflect scientific and clinical evidence that has built over the last decade. This paper presents our updated findings. Objectives to increase consistency of research design, clinical diagnoses and ultimately, care for people with sarcopenia. Recommendations sarcopenia is a muscle disease (muscle failure) rooted in adverse muscle changes that accrue across a lifetime; sarcopenia is common among adults of older age but can also occur earlier in life. In this updated consensus paper on sarcopenia, EWGSOP2: (1) focuses on low muscle strength as a key characteristic of sarcopenia, uses detection of low muscle quantity and quality to confirm the sarcopenia diagnosis, and identifies poor physical performance as indicative of severe sarcopenia; (2) updates the clinical algorithm that can be used for sarcopenia case-finding, diagnosis and confirmation, and severity determination and (3) provides clear cut-off points for measurements of variables that identify and characterise sarcopenia. Conclusions EWGSOP2's updated recommendations aim to increase awareness of sarcopenia and its risk. With these new recommendations, EWGSOP2 calls for healthcare professionals who treat patients at risk for sarcopenia to take actions that will promote early detection and treatment. We also encourage more research in the field of sarcopenia in order to prevent or delay adverse health outcomes that incur a heavy burden for patients and healthcare systems.

Published
2019
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