91 results on '"Torchio B"'
Search Results
2. Detection of breast cancer cell contamination in leukapheresis product by real-time quantitative polymerase chain reaction
- Author
-
Leone, F, Perissinotto, E, Viale, A, Cavalloni, G, Taraglio, S, Capaldi, A, Piacibello, W, Torchio, B, and Aglietta, M
- Published
- 2001
- Full Text
- View/download PDF
Catalog
3. The hazardous burden of Herpesviridae in inflammatory bowel disease: The case of refractory severe ulcerative colitis
- Author
-
Lavagna, A., Bergallo, M., Daperno, M., Sostegni, R., Ravarino, N., Crocellà, L., Ramella, A., Rocca, R., Torchio, B., Cavallo, R., and Pera, A.
- Published
- 2006
- Full Text
- View/download PDF
4. Thyroid cancer histotype changes as observed in a major general hospital in a 21-year period
- Author
-
Deandrea, M., Gallone, G., Veglio, M., Balsamo, A., Grassi, A., Sapelli, S., Rossi, C., Nasi, R. G., Porcellana, V., Varvello, G., Capussotti, L., Taraglio, S., Ravarino, N., Torchio, B., and Fonzo, D. more...
- Published
- 1997
- Full Text
- View/download PDF
5. SIX-TIME POINTS 13C-UREA BREATH TEST IS A SUITABLE METHOD FOR HELICOBACTER PILORY DIAGNOSIS IN POSTGASTRECTOMY PATIENTS
- Author
-
Lombardo, L., Masoero, G., Monica, P. Della, Taraglio, S., Motta, M., Ravarino, N., Torchio, B., and Pera, A.
- Published
- 1999
6. EXPRESSION OF COX-2 IN HUMAN BREAST CANCER CELLS AS A CRITICAL DETERMINANT OF EPITHELIAL-MESENCHYMAL TRANSITION AND INVASIVENESS
- Author
-
Ievolella, M, Bocca, Claudia, Autelli, Riccardo, Motta, M, Torchio, B, Mosso, L, Cannito, Stefania, Paternostro, Claudia, Colombatto, S, Parola, Maurizio, and Miglietta, Antonella
- Published
- 2013
7. Dati Preliminari dello studio multicentrico italiano sui tumori primitivi del cuore promosso dal Gruppo di Studio Italiano di Patologia Cardiovascolare
- Author
-
Pucci, A, Bartoloni, Giovanni, Celeste, A, Ravarino, N, Torchio, B, Motta, M, Mosso, L, Delsedime, L, Passarino, G, Burlo, P, Basso, C, Thiene, G, Leone, O, Anichini, C, Gori, F, Orlandi, A, DI GIOIA, C, Giordano, C, D'Amati, G, Gallo, P, Esposito, S, and Agozzino, L. more...
- Published
- 2006
8. Primary signet ring cell adenocarcinoma of the bladder
- Author
-
Marino, G, Motta, E, Mosso, L, Bocca, Claudia, Ravarino, N, and Torchio, B.
- Published
- 2005
9. Immunological Features of Simple Endemic Goitre
- Author
-
Costa, A., Ricci, C., Benedetto, V., Borelli, Paola, Fadda, Emanuela, Ravarino, Nicoletta, Torchio, B., Urbano, D., Fragapane, P., Varvello, G., Pinchera, A., editor, Ingbar, S. H., editor, McKenzie, J. M., editor, and Fenzi, G. F., editor more...
- Published
- 1987
- Full Text
- View/download PDF
10. P.1.216: DECREASING PREVALENCE OF HELICOBACTER PYLORI INFECTION AND INCIDENCE OF GASTRIC CANCER IN NORTH WEST ITALY
- Author
-
Lombardo, L., primary, Rocca, R., additional, Lavagna, A., additional, Motta, M., additional, Torchio, B., additional, Giostra, A., additional, Chiecchio, A., additional, and Masoero, G., additional
- Published
- 2011
- Full Text
- View/download PDF
11. ATROPHIC GASTRITIS PHENOTYPES DIAGNOSIS USING GASTROPANEL: PIEDMONT EXPERIENCE
- Author
-
Lombardo, L., primary, Leto, R., additional, Molinaro, G., additional, Ravarino, N., additional, and Torchio, B., additional
- Published
- 2009
- Full Text
- View/download PDF
12. Successful IVF programme after conservatively treated endometrial cancer
- Author
-
Sodano, M, primary, Bogliatto, F, additional, Morero, S, additional, Mosso, L, additional, Torchio, B, additional, and Leidi, L, additional
- Published
- 2009
- Full Text
- View/download PDF
13. FNA cytology of thyroid neurilemmoma (schwannoma)
- Author
-
Andrion, A., Mazzucco, Gianna, and Torchio, B.
- Published
- 1992
14. What is meant today by Hashimoto’s thyroiditis?
- Author
-
Costa, A., Torchio, B., Zoppetti, G., and Feyless, E.
- Published
- 1989
- Full Text
- View/download PDF
15. Poorly Differentiated Oxyphilic (Hurthle Cell) Carcinomas of the Thyroid
- Author
-
Papotti, M., primary, Torchio, B., additional, Grassi, L., additional, Favero, A., additional, and Bussolati, G., additional
- Published
- 1996
- Full Text
- View/download PDF
16. Serum autoantibodies and thyroid lymphocytic infiltration in endemic goitre.
- Author
-
Costa, A., De Filippis, V., Balsamo, A., Ravarino, Nicoletta, Testori, Ornella, Torchio, B., Valmaggia, Piera, and Zoppetti, G.
- Subjects
GOITER ,AUTOANTIBODIES ,THYROID diseases ,THYROGLOBULIN ,GRAVES' disease - Abstract
Patients with thyroid diseases from areas of endemic goitre in Northern Italy were examined for thyroid antibodies by passive haemoagglutination. Of 40 schoolboys with goitre only one had thyroid antibodies (AT) in the blood. Among 182 adults with grade 1-2 goitre, examined within an area of low endemia, the frequency of AT was 7%, not significantly different from that found in the 286 persons with thyroid `O' living in the same area. Among 181 adults with grade 2-3 goitre, examined within an area of serious endemia, the frequency of AT was 16%; the percentage went up to 24% in 144 patients operated on for goitre. AT frequency was 36% in 87 patients with toxic goitre, more than 70% in 97 patients with Graves' disease and 17% in 60 patients with cancer of the thyroid. AT occurred three times more frequently in women than in men. Microsomal antibodies were more frequently detected than anti-thyroglobulin antibodies: the opposite was true in thyroid cancer. Lymphocytic infiltration (IL) of the gland was observed in 45% of the 464 simple goitres and in 52% of the 60 cancers of the thyroid: it was more frequent and intense in women. Among the 144 patients operated on for goitre the frequency and the titre of AT progressed in parallel with the intensity of the lymphocytic infiltration. Patients with a greater lymphocytic infiltration and higher AT had a higher TSH. Multinodular non-toxic goitre and autoimmune lymphocytic thyroiditis can be present in the same thyroid gland and the clinical expression will depend on which condition predominates. [ABSTRACT FROM AUTHOR] more...
- Published
- 1984
17. Nefroma cistico multiloculare del rene. Descrizione di un caso e considerazioni cliniche.
- Author
-
MARINO, G., SURLETI, D., LAUDI, M., MOTTA, M., MOSSO, L., RAVARINO, N., and TORCHIO, B.
- Subjects
KIDNEY abnormalities ,POTTER'S syndrome ,SYNDROMES ,PELTIGERACEAE ,NEPHROMA (Lichens) ,CANCER ,TUMORS ,DISEASES ,DRUG therapy ,CARCINOGENS ,INCURABLE diseases - Abstract
Copyright of Urologia Journal is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) more...
- Published
- 2008
18. Serum autoantibodies and thyroid lymphocytic infiltration in endemic goitre
- Author
-
Costa, A, de Filippis, V, Balsamo, A, Ravarino, N, Testori, O, Torchio, B, Valmaggia, P, and Zoppetti, G
- Subjects
Adult ,Male ,endocrine system ,endocrine system diseases ,Adolescent ,Thyroid Gland ,Hemagglutination Tests ,Sex Factors ,Microsomes ,Humans ,Female ,Lymphocytes ,Thyroid Neoplasms ,Child ,Goiter, Endemic ,Research Article ,Autoantibodies - Abstract
Patients with thyroid diseases from areas of endemic goitre in Northern Italy were examined for thyroid antibodies by passive haemoagglutination. Of 40 schoolboys with goitre only one had thyroid antibodies (AT) in the blood. Among 182 adults with grade 1-2 goitre, examined within an area of low endemia, the frequency of AT was 7%, not significantly different from that found in the 286 persons with thyroid 'O' living in the same area. Among 181 adults with grade 2-3 goitre, examined within an area of serious endemia, the frequency of AT was 16%; the percentage went up to 24% in 144 patients operated on for goitre. AT frequency was 36% in 87 patients with toxic goitre, more than 70% in 97 patients with Graves' disease and 17% in 60 patients with cancer of the thyroid. AT occurred three times more frequently in women than in men. Microsomal antibodies were more frequently detected than anti-thyroglobulin antibodies: the opposite was true in thyroid cancer. Lymphocytic infiltration (IL) of the gland was observed in 45% of the 464 simple goitres and in 52% of the 60 cancers of the thyroid: it was more frequent and intense in women. Among the 144 patients operated on for goitre the frequency and the titre of AT progressed in parallel with the intensity of the lymphocytic infiltration. Patients with a greater lymphocytic infiltration and higher AT had a higher TSH. Multinodular non-toxic goitre and autoimmune lymphocytic thyroiditis can be present in the same thyroid gland and the clinical expression will depend on which condition predominates. more...
- Published
- 1984
19. Flow cytometric DNA analysis of cirrhotic liver cells in patients with hepatocellular carcinoma can provide a new prognostic factor
- Author
-
Rua, S., Comino, A., Fruttero, A., Torchio, P., Bouzari, H., Taraglio, S., Torchio, B., and Capussotti, L.
- Subjects
Usage ,Analysis ,Prognosis ,Liver cancer -- Prognosis ,Flow cytometry -- Usage -- Analysis ,DNA -- Analysis -- Usage ,Liver cirrhosis -- Analysis -- Prognosis - Abstract
According to the authors' abstract of an article published in Cancer, 'BACKGROUND: DNA flow cytometry of hepatocellular carcinoma (HCC) cells has been investigated in many studies, but, to the best [...] more...
- Published
- 1996
20. Immunological features of endemic goiter
- Author
-
Costa, A., primary, Benedetto, V., additional, Ricci, C., additional, Borelli, P., additional, Fadda, E., additional, Ravarino, N., additional, Torchio, B., additional, Dario, U., additional, Fragapane, P., additional, Varvello, G., additional, and De Filippis, V., additional more...
- Published
- 1986
- Full Text
- View/download PDF
21. Epidermal Growth Factor Receptor (EGFR) mutation analysis, gene expression profiling and EGFR protein expression in primary prostate cancer
- Author
-
Cavalloni Giuliana, Pignochino Ymera, Segir Raffaella, Montemurro Filippo, Mello-Grand Maurizia, Migliardi Giorgia, Peraldo-Neia Caterina, Torchio Bruno, Mosso Luciano, Chiorino Giovanna, and Aglietta Massimo more...
- Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Activating mutations of the epidermal growth factor receptor (EGFR) confer sensitivity to the tyrosine kinase inhibitors (TKi), gefitinib and erlotinib. We analysed EGFR expression, EGFR mutation status and gene expression profiles of prostate cancer (PC) to supply a rationale for EGFR targeted therapies in this disease. Methods Mutational analysis of EGFR TK domain (exons from 18 to 21) and immunohistochemistry for EGFR were performed on tumour tissues derived from radical prostatectomy from 100 PC patients. Gene expression profiling using oligo-microarrays was also carried out in 51 of the PC samples. Results EGFR protein overexpression (EGFRhigh) was found in 36% of the tumour samples, and mutations were found in 13% of samples. Patients with EGFRhigh tumours experienced a significantly increased risk of biochemical relapse (hazard ratio-HR 2.52, p=0.02) compared with patients with tumours expressing low levels of EGFR (EGFRlow). Microarray analysis did not reveal any differences in gene expression between EGFRhigh and EGFRlow tumours. Conversely, in EGFRhigh tumours, we were able to identify a 79 gene signature distinguishing mutated from non-mutated tumours. Additionally, 29 genes were found to be differentially expressed between mutated/EGFRhigh (n=3) and mutated/EGFRlow tumours (n=5). Four of the down-regulated genes, U19/EAF2, ABCC4, KLK3 and ANXA3 and one of the up-regulated genes, FOXC1, are involved in PC progression. Conclusions Based on our findings, we hypothesize that accurate definition of the EGFR status could improve prognostic stratification and we suggest a possible role for EGFR-directed therapies in PC patients. Having been generated in a relatively small sample of patients, our results warrant confirmation in larger series. more...
- Published
- 2011
- Full Text
- View/download PDF
22. Sorafenib blocks tumour growth, angiogenesis and metastatic potential in preclinical models of osteosarcoma through a mechanism potentially involving the inhibition of ERK1/2, MCL-1 and ezrin pathways
- Author
-
Ferrari Stefano, Torchio Bruno, Alberghini Marco, Camussi Giovanni, Migliardi Giorgia, Gammaitoni Loretta, Bottos Alessia, Bruno Stefania, Tapparo Marta, Motta Manuela, Cavalloni Giuliana, Grignani Giovanni, Pignochino Ymera, Bussolino Federico, Fagioli Franca, Picci Piero, and Aglietta Massimo more...
- Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Osteosarcoma (OS) is the most common primary bone tumour in children and young adults. Despite improved prognosis, metastatic or relapsed OS remains largely incurable and no significant improvement has been observed in the last 20 years. Therefore, the search for alternative agents in OS is mandatory. Results We investigated phospho-ERK 1/2, MCL-1, and phospho-Ezrin/Radixin/Moesin (P-ERM) as potential therapeutic targets in OS. Activation of these pathways was shown by immunohistochemistry in about 70% of cases and in all OS cell lines analyzed. Mutational analysis revealed no activating mutations in KRAS whereas BRAF gene was found to be mutated in 4/30 OS samples from patients. Based on these results we tested the multi-kinase inhibitor sorafenib (BAY 43-9006) in preclinical models of OS. Sorafenib inhibited OS cell line proliferation, induced apoptosis and downregulated P-ERK1/2, MCL-1, and P-ERM in a dose-dependent manner. The dephosphorylation of ERM was not due to ERK inhibition. The downregulation of MCL-1 led to an increase in apoptosis in OS cell lines. In chick embryo chorioallantoic membranes, OS supernatants induced angiogenesis, which was blocked by sorafenib and it was also shown that sorafenib reduced VEGF and MMP2 production. In addition, sorafenib treatment dramatically reduced tumour volume of OS xenografts and lung metastasis in SCID mice. Conclusion In conclusion, ERK1/2, MCL-1 and ERM pathways are shown to be active in OS. Sorafenib is able to inhibit their signal transduction, both in vitro and in vivo, displaying anti-tumoural activity, anti-angiogenic effects, and reducing metastatic colony formation in lungs. These data support the testing of sorafenib as a potential therapeutic option in metastatic or relapsed OS patients unresponsive to standard treatments. more...
- Published
- 2009
- Full Text
- View/download PDF
23. Solitary fibrous tumor of the thyroid: report of three cases with a focus on cytological features and histological clues for malignancy.
- Author
-
Santoro F, Linari A, Maletta F, Parente R, Torchio B, Rossi ED, Messuti I, Borasi A, Volante M, and Papotti M
- Subjects
- Humans, Thyroid Gland pathology, Biopsy, STAT6 Transcription Factor genetics, Biomarkers, Tumor analysis, Solitary Fibrous Tumors pathology, Hemangiopericytoma
- Abstract
Solitary fibrous tumor is a mesenchymal tumor of intermediate malignant potential characterized by a recurrent NAB2::STAT6 fusion and STAT6 nuclear expression. Primary thyroid solitary fibrous tumor is relatively uncommon, with 45 cases described in the English literature to date. Although its histologic features are characteristic, its diagnosis in the thyroid can be problematic, especially in small biopsies or cytology specimens. We herein present three new cases of thyroid solitary fibrous tumor, one of which is malignant, with new insights on the morphological spectrum and malignant potential of this tumor. We additionally provide a review of the literature with a focus on the clues and challenges of a preoperative cytological diagnosis of this tumor, which can nowadays be supported by STAT6 nuclear expression, when appropriately suspected., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) more...
- Published
- 2023
- Full Text
- View/download PDF
24. Expression of Cox-2 in human breast cancer cells as a critical determinant of epithelial-to-mesenchymal transition and invasiveness.
- Author
-
Bocca C, Ievolella M, Autelli R, Motta M, Mosso L, Torchio B, Bozzo F, Cannito S, Paternostro C, Colombatto S, Parola M, and Miglietta A
- Subjects
- Basic Helix-Loop-Helix Transcription Factors metabolism, Cadherins metabolism, Cell Line, Tumor, Cyclooxygenase 2 genetics, DNA, Complementary genetics, Dinoprostone metabolism, Female, Heme Oxygenase-1 metabolism, Humans, Hypoxia metabolism, MCF-7 Cells, Neoplasm Invasiveness, Reactive Oxygen Species metabolism, Snail Family Transcription Factors, Transcription Factors metabolism, Breast Neoplasms metabolism, Cyclooxygenase 2 metabolism, Epithelial-Mesenchymal Transition
- Abstract
Introduction: Cyclooxygenase-2 (COX-2) is overexpressed in several malignancies and is implicated in breast cancer progression., Objectives: We investigated whether changes in COX-2 expression may affect epithelial-to-mesenchymal transition (EMT) and then invasive potential of human breast cancer cells, in relationship with hypoxia. COX-2-null MCF-7 human breast cancer cells, MCF-7 cells transiently expressing COX-2 and COX-2-expressing MDA-MB-231 cells were employed., Results: COX-2 overexpression resulted in downregulation of E-cadherin and β-catenin, upregulation of vimentin, N-cadherin and SNAI1, suggesting EMT occurrence. COX-2-overexpressing MCF-7 cells were also characterized by increased invasiveness and release of matrix-metalloproteinase-9. The above-mentioned characteristics, homologous to those detected in highly invasive MDA-MB-231 cells, were reverted by treatment of COX-2-overexpressing MCF-7 cells with celecoxib, a COX-2-specific inhibitor, partly through the inhibition of COX-2-related intracellular generation of reactive oxygen species. Hypoxia further exacerbated COX-2 expression, EMT changes and invasive ability in both COX-2-overexpressing MCF-7 cells and MDA-MB-231 cells. Finally, immunohistochemistry performed on samples from normal and neoplastic human breast tissues revealed that COX-2-positive malignant cells were also positive for EMT-related antigens, hypoxia-inducible factor (HIF)-2α and the oxidative stress marker heme oxygenase., Conclusions: These findings support the existence of a direct link between COX-2 overexpression, EMT and invasiveness in human breast cancer cells, emphasizing the role of hypoxic microenvironment. more...
- Published
- 2014
- Full Text
- View/download PDF
25. Prospective evaluation of accuracy of liver biopsy findings in the identification of chemotherapy-associated liver injuries.
- Author
-
Viganò L, Ravarino N, Ferrero A, Motta M, Torchio B, and Capussotti L
- Abstract
OBJECTIVE To evaluate the accuracy of liver biopsy findings in preoperative assessment of chemotherapy-associated liver injuries (CALIs). DESIGN Prospective study. SETTING Tertiary care referral hospital. PATIENTS From July 1, 2007, to January 31, 2011, all patients with colorectal metastases receiving preoperative oxaliplatin- and/or irinotecan-based chemotherapy (≥4 cycles) were considered for the present study. Patients underwent parenchymal biopsy before liver resection. Blinded CALI evaluation was performed on biopsy and resection specimens. INTERVENTION Liver resection. MAIN OUTCOME MEASURES Sensitivity, specificity, and accuracy of liver biopsy in CALI evaluation. RESULTS We included 100 patients. At specimen analysis, grade 2 or 3 steatosis was diagnosed in 30 patients; grade 2 or 3 sinusoidal dilatation, in 28; grade 2 hepatocellular ballooning, in 3; grade 2 or 3 lobular inflammation, in 25; and steatohepatitis in 19. Obesity was associated with grade 3 steatosis (20.8% vs 5.3%; odds ratio [OR], 4.74 [P = .03]) and steatohepatitis (33.3% vs 14.5%; OR, 2.96 [P = .04]). Oxaliplatin administration was associated with higher sinusoidal dilatation grade (P = .049). Mortality (2 cases) was increased among patients with steatohepatitis (10.5% vs 0; OR, 13.67 [P = .04]). Biopsy findings correctly predicted steatosis (sensitivity, 88.9%; accuracy, 93.0%) but had low sensitivity and accuracy for sinusoidal dilatation (21.4% and 63.0%, respectively), hepatocellular ballooning (16.0% and 69.0%, respectively), lobular inflammation (20.0% and 78.0%, respectively), and steatohepatitis (21.1% and 79.0%, respectively). Biopsy accuracy did not improve regarding specific chemotherapy regimens or prolonged treatments. CONCLUSIONS Liver biopsy cannot be considered a reliable tool in assessing CALIs except for steatosis. The procedure should not be recommended during preoperative workup. more...
- Published
- 2012
- Full Text
- View/download PDF
26. High diagnostic accuracy and interobserver reliability of real-time elastography in the evaluation of thyroid nodules.
- Author
-
Ragazzoni F, Deandrea M, Mormile A, Ramunni MJ, Garino F, Magliona G, Motta M, Torchio B, Garberoglio R, and Limone P
- Subjects
- Adult, Aged, Aged, 80 and over, Computer Systems, Female, Humans, Male, Middle Aged, Observer Variation, Reproducibility of Results, Sensitivity and Specificity, Elasticity Imaging Techniques methods, Thyroid Nodule diagnostic imaging
- Abstract
Elastography is a new diagnostic tool in the evaluation of thyroid nodules. Aim of the study was to evaluate the accuracy and reliability of elastography in discriminating thyroid lesions and the interobserver variability. One hundred thirty-two nodules in 115 patients selected for thyroid surgery underwent conventional ultrasound and elastographic evaluation. Elastography score was divided in four categories (totally elastic nodule, mainly elastic, mainly rigid and totally rigid) according to signal distribution. Three independent operators conducted the study. Final histology showed 92 benign nodules and 40 malignant. On elastography, 77/92 benign nodules were classified as score 1 or 2 and 34/40 malignant nodules as score 3 or 4 (sensitivity 85%, specificity 83.7%, positive predictive value [PPV] 69.3%, negative predictive value [NPV] 92.7%). Rate of concordance between operators was good (K test: 0.64, p < 0.0001). Simple to use, with good interobserver agreement, elastography has all the requisites to become an important complement of conventional US examination in the near future., (Copyright © 2012 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.) more...
- Published
- 2012
- Full Text
- View/download PDF
27. Genetic and expression analysis of MET, MACC1, and HGF in metastatic colorectal cancer: response to met inhibition in patient xenografts and pathologic correlations.
- Author
-
Galimi F, Torti D, Sassi F, Isella C, Corà D, Gastaldi S, Ribero D, Muratore A, Massucco P, Siatis D, Paraluppi G, Gonella F, Maione F, Pisacane A, David E, Torchio B, Risio M, Salizzoni M, Capussotti L, Perera T, Medico E, Di Renzo MF, Comoglio PM, Trusolino L, and Bertotti A more...
- Subjects
- Aged, Aged, 80 and over, Animals, Antineoplastic Agents pharmacology, Antineoplastic Agents therapeutic use, Biomarkers, Pharmacological analysis, Biomarkers, Tumor analysis, Biomarkers, Tumor genetics, Carcinoma drug therapy, Carcinoma pathology, Colorectal Neoplasms drug therapy, Colorectal Neoplasms pathology, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic drug effects, Humans, Male, Mice, Mice, Inbred NOD, Mice, SCID, Middle Aged, Neoplasm Metastasis, Protein Kinase Inhibitors pharmacology, Protein Kinase Inhibitors therapeutic use, Trans-Activators, Xenograft Model Antitumor Assays, Carcinoma genetics, Colorectal Neoplasms genetics, Hepatocyte Growth Factor genetics, Proto-Oncogene Proteins c-met antagonists & inhibitors, Proto-Oncogene Proteins c-met genetics, Receptors, Growth Factor antagonists & inhibitors, Receptors, Growth Factor genetics, Transcription Factors genetics
- Abstract
Purpose: We determined the gene copy numbers for MET, for its transcriptional activator MACC1 and for its ligand hepatocyte growth factor (HGF) in liver metastases from colorectal carcinoma (mCRC). We correlated copy numbers with mRNA levels and explored whether gain and/or overexpression of MET and MACC1 predict response to anti-Met therapies. Finally, we assessed whether their genomic or transcriptional deregulation correlates with pathologic and molecular parameters of aggressive disease., Experimental Design: One hundred three mCRCs were analyzed. Copy numbers and mRNA were determined by quantitative PCR (qPCR). Thirty nine samples were implanted and expanded in NOD (nonobese diabetic)/SCID (severe combined immunodeficient) mice to generate cohorts that were treated with the Met inhibitor JNJ-38877605. In silico analysis of MACC1 targets relied on genome-wide mapping of promoter regions and on expression data from two CRC datasets., Results: No focal, high-grade amplifications of MET, MACC1, or HGF were detected. Chromosome 7 polysomy and gain of the p-arm were observed in 21% and 8% of cases, respectively, and significantly correlated with higher expression of both Met and MACC1. Met inhibition in patient-derived xenografts did not modify tumor growth. Copy number gain and overexpression of MACC1 correlated with unfavorable pathologic features better than overexpression of Met. Bioinformatic analysis of putative MACC1 targets identified elements besides Met, whose overexpression cosegregated with aggressive forms of colorectal cancer., Conclusions: Experiments in patient-derived xenografts suggest that mCRCs do not rely on Met genomic gain and/or overexpression for growth. On the basis of pathologic correlations and bioinformatic analysis, MACC1 could contribute to CRC progression through mechanisms other than or additional to Met transcriptional upregulation., (©2011 AACR.) more...
- Published
- 2011
- Full Text
- View/download PDF
28. Diagnostic value of a cytomorphological subclassification of follicular patterned thyroid lesions: a study of 927 consecutive cases with histological correlation.
- Author
-
Deandrea M, Ragazzoni F, Motta M, Torchio B, Mormile A, Garino F, Magliona G, Gamarra E, Ramunni MJ, Garberoglio R, and Limone PP
- Subjects
- Adenocarcinoma, Follicular pathology, Adenoma, Oxyphilic diagnosis, Adenoma, Oxyphilic pathology, Biopsy, Fine-Needle methods, Humans, Thyroid Neoplasms diagnosis, Thyroid Neoplasms pathology, Thyroid Nodule pathology, Adenocarcinoma, Follicular diagnosis, Thyroid Gland pathology, Thyroid Nodule diagnosis
- Abstract
Background: Fine-needle aspiration cytology (FNAC) has proved to be an effective diagnostic tool in patients with thyroid nodules. Several reporting schemes have been suggested to define the risk of malignancy and consequent clinical management. To date, however, among lesions showing a follicular pattern, FNAC is still unable to differentiate between benign and malignant ones. The aim of our study was to evaluate whether a subclassification of follicular cytologic specimens, based on cytoarchitectural patterns, could differentiate categories with a different risk of malignancy, thus improving the clinical management of patients harboring follicular nodules., Methods: We report a cohort of 927 consecutive cases who underwent thyroid surgery in our hospital between 2000 and 2008. Each patient underwent FNAC before surgery. All the cytologic specimens were divided into five categories (Thy 1: inadequate material, Thy 2: benign, Thy 3: indeterminate, Thy 4: suspicious for malignancy, Thy 5: malignant). Thy3 specimens were further divided into three subcategories (Thy 3a, or "follicular lesions of indeterminate significance": scant colloid, microfollicular pattern, or small clusters of thyrocytes with round nuclei usually without, but sometimes with, minimal cellular pleomorphism; Thy 3b, or "follicular neoplasm": absence of colloid, small clusters, or microfollicles of medium-large sized cell populations arranged in cohesive groups with nuclear overlapping, crowding, and pleomorphisms; and Thy 3c or "Hurthle-cell neoplasm": scant colloid, sheets or clusters of oxyphilic cells)., Results: Thy 1 specimens (51 cases on the whole) proved to be malignant in 5.88% (3 cases), Thy 2 specimens (319) in 3.45% (11 cases), Thy 4 specimens (91) in 84.62% (77 cases), and Thy 5 specimens (172) in 98.84% (170 cases). Thy 3 specimens (294 cases) proved to be malignant in 17.35% as a whole, but when divided into the three subcategories, the percentage of malignant cases was significantly different between the Thy 3a group (4.95%) and the Thy 3b and Thy 3c groups (25.0% and 22.77% respectively)., Conclusions: This study supports the National Cancer Institute consensus showing a different risk of malignancy for "follicular lesions of undetermined significance” compared with "follicular neoplasms" and "Hurthle cells neoplasms," which are more suspect for malignancy. This subclassification could improve clinical management of thyroid nodules, helping to better select patients for surgery or follow up. more...
- Published
- 2010
- Full Text
- View/download PDF
29. Prevalence of atrophic gastritis in dyspeptic patients in Piedmont. A survey using the GastroPanel test.
- Author
-
Lombardo L, Leto R, Molinaro G, Migliardi M, Ravarino N, Rocca R, and Torchio B
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Endoscopy, Digestive System, Female, Gastritis, Atrophic diagnosis, Gastritis, Atrophic pathology, Gastrointestinal Tract immunology, Gastrointestinal Tract microbiology, Helicobacter pylori immunology, Helicobacter pylori physiology, Humans, Italy, Male, Middle Aged, Sensitivity and Specificity, Young Adult, Data Collection, Dyspepsia complications, Gastritis, Atrophic complications, Gastritis, Atrophic epidemiology, Serologic Tests methods
- Abstract
Background: Chronic atrophic gastritis (CAG) is a precursor of the intestinal type of gastric cancer, the second leading cause of cancer-related death worldwide. GastroPanel is a recently marketed serological kit for the non-invasive diagnosis of CAG, defined by some authors "even more reliable than biopsy histology". The goal of this study was 1) to evaluate the agreement between the serum gastric profile provided by GastroPanel (PGI, PGII, G-17, AbHp) and histology over CAG diagnosis, and 2) to evaluate the prevalence of CAG by means of GastroPanel in a Northern Italian dyspeptic population., Methods: Basal blood samples for GastroPanel parameters evaluation (Biohit Plc, Finland) were collected after an overnight fast from 1387 dyspeptic patients (age range: 18-80 years; F 704). Gastroscopy with two biopsies each of the antrum and corpus was offered to a group of the first 400 consecutive patients (age 18-80 years, F 214) to compare the results of histology and GastroPanel in CAG., Results: Agreement between GastroPanel and histology for corpus-prevalent CAG was 94%, with a sensitivity and specificity of 80% and 96%, respectively. In our series of 1387 dyspeptic patients, the prevalence of corpus-prevalent CAG, of antral-prevalent CAG and of multifocal CAG (antrum+ corpus) was 10.7%, 3.6% and 2.4%, respectively. Out of the 34 patients with multifocal atrophic gastritis, 12% were under 30 years of age., Conclusions: GastroPanel is a reliable non-invasive test for diagnosis of CAG and deserves consideration for current use in clinical practice as a valuable diagnostic tool. more...
- Published
- 2010
- Full Text
- View/download PDF
30. COX-2 expression in human breast carcinomas: correlation with clinicopathological features and prognostic molecular markers.
- Author
-
Miglietta A, Toselli M, Ravarino N, Vencia W, Chiecchio A, Bozzo F, Motta M, Torchio B, and Bocca C
- Subjects
- Adult, Aged, Aged, 80 and over, Breast Neoplasms diagnosis, Breast Neoplasms genetics, Breast Neoplasms pathology, Carcinoma, Ductal, Breast diagnosis, Carcinoma, Ductal, Breast pathology, Carcinoma, Ductal, Breast secondary, Carcinoma, Lobular diagnosis, Carcinoma, Lobular pathology, Carcinoma, Lobular secondary, Female, Humans, Immunohistochemistry, Lymph Nodes metabolism, Lymph Nodes pathology, Lymphatic Metastasis, Middle Aged, Neoplasm Staging, Neovascularization, Pathologic, Prognosis, Tumor Burden, Up-Regulation, Biomarkers, Tumor metabolism, Breast Neoplasms metabolism, Carcinoma, Ductal, Breast metabolism, Carcinoma, Lobular metabolism, Cyclooxygenase 2 metabolism, Gene Expression Regulation, Neoplastic
- Abstract
Objective: COX-2 is implicated in carcinogenesis and tumour progression in many cancers, including breast cancer. Recently, it has been reported that human breast carcinomas aberrantly express COX-2, and that raised tissue levels of COX-2 may have prognostic value. Patients expressing high levels of COX-2 can develop local recurrence, and have reduced disease-free and disease-related overall survival. The aim of this study was to investigate COX-2 expression in human ductal and lobular breast cancers and its possible association with clinicopathological features and prognostic molecular markers., Research Design and Methods: Cytoplasmic COX-2 expression was detected by means of immunohistochemistry in a series of 91 breast carcinomas with ductal (n = 60) and lobular (n = 31) patterns. COX-2 expression was investigated by multivariate analyses and compared with clinicopathological features., Results and Conclusions: COX-2 immune positivity and percentage of positive cells correlated significantly with the size, grading, extent of primary tumour and vascular invasion of carcinoma but not with biological parameters (estrogen receptor, progesterone receptor and human EGF receptor 2). The findings of the present study suggest that COX-2 overexpression in lobular and ductal breast cancers, which correlates with traditional clinico-pathological parameters, may be considered as a negative prognostic marker. more...
- Published
- 2010
- Full Text
- View/download PDF
31. Case report: Successful IVF programme after conservatively treated endometrial cancer.
- Author
-
Sodano M, Bogliatto F, Morero S, Mosso L, Torchio B, and Leidi L
- Subjects
- Adult, Endometrial Neoplasms pathology, Female, Humans, Pregnancy, Pregnancy Outcome, Treatment Outcome, Antineoplastic Agents, Hormonal therapeutic use, Embryo Transfer methods, Endometrial Neoplasms drug therapy, Fertilization in Vitro methods, Megestrol Acetate therapeutic use
- Abstract
Some cases of successful pregnancy after conservative endometrial cancer management have been reported. This paper presents such a case, an infertile patient with conservatively treated endometrial cancer (stage 1a grade 1) who conceived and carried a successful pregnancy after IVF treatment. The conservative treatment consisted of hysteroscopic biopsies and oral megestrol acetate 600 mg daily for 3 months. At the end of the treatment the endometrial cancer remitted to simple endometrial hyperplasia. IVF was performed immediately and 32 days after embryo transfer an intrauterine single gestational sac with fetal pole and heartbeat was detected by transvaginal ultrasound. The woman received routine obstetric care and a caesarean section was performed at 38 weeks of gestation. The histological evaluation after delivery showed no evidence of recurrent disease. Twenty-six months after the delivery, the woman is healthy and free of the disease. It is concluded that conservative treatment of stage 1a and grade 1 endometrial adenocarcinoma is an available option in young women who wish to preserve their fertility. more...
- Published
- 2009
- Full Text
- View/download PDF
32. Primary signet ring cell adenocarcinoma of the bladder.
- Author
-
Marino G, Motta E, Mosso L, Bocca C, Ravarino N, and Torchio B
- Subjects
- Aged, Cystectomy, Humans, Male, Urethra surgery, Urinary Diversion, Carcinoma, Signet Ring Cell diagnosis, Carcinoma, Signet Ring Cell surgery, Urinary Bladder Neoplasms diagnosis, Urinary Bladder Neoplasms surgery
- Published
- 2005
33. Thyroid cytology and risk of thyroid cancer: differences among indeterminate specimens.
- Author
-
Deandrea M, Motta M, Divito L, Mormile A, Gallone G, Grassi A, Pellerito R, Nasi P, Torchio B, Garberoglio R, and Fonzo D
- Subjects
- Biopsy, Fine-Needle, Humans, Predictive Value of Tests, Risk, Thyroid Gland cytology, Thyroid Diseases pathology, Thyroid Gland pathology, Thyroid Neoplasms pathology
- Abstract
Objective: To assess the potential for stratification of indeterminate cytologic findings on fine-needle aspiration (FNA) of thyroid nodules in an effort to improve therapeutic strategies., Methods: We attempted to determine the malignant risk associated with various indeterminate FNA cytologic patterns by correlation of specimens with the final histologic diagnosis. For this analysis, we identified 294 computerized medical records of surgically treated thyroid nodules during a 5-year period at our institution with the corresponding FNA cytology reports available., Results: Of the 294 surgical cases, 162 with a positive or indeterminate cytologic report were selected, reviewed, and classified. Of 52 patients with positive cytologic findings on FNA, 51 (98%) had a final histologic report of a malignant thyroid nodule. Of 110 patients with indeterminate specimens, 30 (27%) had a final histologic diagnosis of thyroid carcinoma. The presence of nuclear atypia was predictive of thyroid carcinoma in 75% of patients, a Hürthle cell cytologic pattern was associated with a malignant thyroid nodule in 33%, and a hypercellular smear was suggestive of malignant involvement in 26% of cases. The lowest rate of malignant potential was associated with cytologic microfollicular and scant colloid alone subtype (6%)., Conclusion: The results of this study show that indeterminate thyroid cytologic specimens can be subdivided into groups with different malignant risks. A microfollicular cytologic pattern in the absence of a hypercellular smear or nuclear atypia does not support a recommendation of surgical treatment. A malignant cytologic diagnosis has a high positive predictive value for detection of thyroid cancer. more...
- Published
- 2004
- Full Text
- View/download PDF
34. Poorly differentiated carcinomas of the thyroid with trabecular, insular, and solid patterns: a clinicopathologic study of 183 patients.
- Author
-
Volante M, Landolfi S, Chiusa L, Palestini N, Motta M, Codegone A, Torchio B, and Papotti MG
- Subjects
- Adenocarcinoma mortality, Adenocarcinoma therapy, Adenocarcinoma, Scirrhous mortality, Adenocarcinoma, Scirrhous pathology, Adenocarcinoma, Scirrhous therapy, Adult, Aged, Analysis of Variance, Biopsy, Needle, Carcinoma surgery, Carcinoma, Papillary mortality, Carcinoma, Papillary pathology, Carcinoma, Papillary surgery, Case-Control Studies, Female, Humans, Immunohistochemistry, Male, Middle Aged, Multivariate Analysis, Neoplasm Staging, Probability, Prognosis, Retrospective Studies, Sex Factors, Survival Analysis, Thyroid Neoplasms mortality, Thyroid Neoplasms surgery, Thyroidectomy methods, Treatment Outcome, Adenocarcinoma pathology, Carcinoma mortality, Carcinoma pathology, Thyroid Neoplasms pathology
- Abstract
Background: The term poorly differentiated (PD) carcinoma was proposed 20 years ago to define aggressive, follicular-derived thyroid carcinomas with behavior intermediate between follicular/papillary and anaplastic carcinomas. Among the variable histologic patterns recognized in such tumors, trabecular-insular-solid (TIS) areas usually are predominant. Conversely, some authors pointed out that PD carcinomas are characterized by unequivocal, high-grade histology with atypias, high mitotic counts, and necrosis rather than by a specific growth pattern., Methods: The clinicopathologic features of a series of 183 thyroid carcinomas with predominant (n = 165 tumors) or focal (n = 18 tumors) TIS growth patterns were studied by univariate and multivariate overall survival analyses and were compared with clinical outcomes. Subgroups included tumors with predominant oxyphilic features (n = 66 tumors) and (residual) papillary carcinoma features (n = 24 tumors). Control groups of papillary (n = 68 tumors), follicular (n = 71 tumors), and anaplastic (n = 35 tumors) carcinomas also were included for overall survival analysis., Results: TIS carcinomas had an intermediate behavior between papillary/follicular and anaplastic carcinomas (P < 0.0001). Univariate and multivariate statistical analyses demonstrated that age > 45 years (P = 0.007), the presence of necrosis (P < 0.0001), and a mitotic count > 3 per 10 high-power fields (P = 0.01) were associated with poor outcome. A simplified scoring system based on statistically significant parameters allowed the identification of three prognostic subgroups (P < 0.0001)., Conclusions: PD TIS carcinomas overall followed a more aggressive course compared with differentiated thyroid carcinomas, irrespective of the extent of the TIS component. However, a numeric scoring system applied to specific clinicopathologic parameters further may identify three prognostic categories of patients who have significantly different survival rates at 5 years and 10 years., (Copyright 2004 American Cancer Society.) more...
- Published
- 2004
- Full Text
- View/download PDF
35. HER2 testing in gastric cancer: molecular morphology and storage time-related changes in archival samples.
- Author
-
Risio M, De Rosa G, Sarotto I, Casorzo L, Capussotti L, Torchio B, Aglietta M, and Chiecchio L
- Subjects
- Adult, Aged, Aged, 80 and over, Cell Differentiation, Female, Humans, Male, Middle Aged, Specimen Handling, Time Factors, Adenocarcinoma metabolism, Immunohistochemistry methods, In Situ Hybridization, Fluorescence methods, Receptor, ErbB-2 biosynthesis, Stomach Neoplasms metabolism
- Abstract
Seventy-two archival specimens of advanced gastric adenocarcinoma were analyzed by fluorescence in situ hybridization and immunohistochemistry for HER2 gene status. Gene amplification and concomitant protein overexpression were detected in 15.2% of cases. Intratumor topographical variability of HER2 amplification was observed, indicative of the late involvement of HER gene in gastric tumorigenesis. No significant correlations were found between HER2 status and histopathologic type, grade of differentiation, and Goseki classification of carcinomas, suggesting that HER2 gene is variably linked with the morphogenesis of gastric adenocarcinoma. A significant decrease of the incidence of HER2 amplified carcinomas in function of the duration of the storage of paraffin blocks was observed: 42-33% for tumor specimens paraffin-embedded in 2002-2001; 8.3%, 15.7%, 11.1% for the years 2000, 1999, 1998, respectively; 0% for cases embedded during 1997. According to these results, the reliability of the FISH and immunohistochemical assays decreases after prolonged storage of paraffin-embedded specimens. more...
- Published
- 2003
36. Cytogenetic findings in a case of dedifferentiated chondrosarcoma.
- Author
-
Casorzo L, Chiecchio L, Pisacane A, Fumero S, Canavese F, Torchio B, and Risio M
- Subjects
- Aged, Chondrosarcoma pathology, Female, Humans, Karyotyping, Loss of Heterozygosity, Cell Differentiation, Chondrosarcoma genetics
- Abstract
Cytogenetic analysis of a case of dedifferentiated chondrosarcoma with a malignant fibrous histiocytoma (MFH) component revealed a near-triploid karyotype with multiple copies of chromosome 7, deletion of chromosome arm 9p, and a derivative chromosome 19 [add(19p)] in each metaphase. Whereas numerical anomalies of chromosome 7 have been frequently reported in chondrosarcoma, deletion 9p and add (19p) have been observed in MFH. A putative MFH tumor suppressor gene could be present in a critical region on chromosome bands 9p21~p22. more...
- Published
- 2003
- Full Text
- View/download PDF
37. Fine-needle aspiration biopsy of the thyroid: comparison between thyroid palpation and ultrasonography.
- Author
-
Deandrea M, Mormile A, Veglio M, Motta M, Pellerito R, Gallone G, Grassi A, Torchio B, Bradac R, Garberoglio R, and Fonzo D
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Female, Goiter, Nodular diagnosis, Humans, Male, Middle Aged, Thyroid Neoplasms pathology, Thyroid Nodule diagnosis, Biopsy, Needle, Goiter, Nodular pathology, Palpation, Thyroid Nodule pathology, Ultrasonography
- Abstract
Objective: To describe our experience with fine-needle aspiration biopsy (FNAB) of the thyroid and compare our results with direct palpation versus ultrasound scanning (USS) in an area of endemic goiter in Italy., Methods: We considered all patients submitted to ultrasound-guided FNAB of thyroid nodules during a 10-month period at our outpatient clinic and analyzed the following: (1) clinical data (number of nodules and identification of the nodule for FNAB); (2) USS data (number of nodules and identification of the nodule for FNAB on the basis of hypoechoic pattern + blurred perinodal halo + microcalcifications or intranodal color Doppler signal indicative of blood flow); (3) cytologic specimens, categorized as suspicious, malignant, negative, or nondiagnostic; and (4) histologic final report of the cytologically positive nodules., Results: The study group consisted of 348 female and 72 male patients who underwent FNAB of the thyroid at our institution. Among the 140 patients with no palpable thyroid nodules, USS showed that 106 had a single nodule and 34 had multinodular goiters. Among the 182 patients with a single palpable thyroid nodule, USS revealed that 138 had a single nodule, 42 had a multinodular goiter, and 2 had lobe enlargement without detectable nodules. All 98 patients with multinodular palpable goiter had a similar pattern on USS. Of the 420 cytologic specimens, 46(11.0%) were positive for thyroid cancer, 313 (74.5%)were negative, and 61 (14.5%) were nondiagnostic. Histologic malignant growth was confirmed in 27 cytologically positive nodules. Of these histologically malignant nodules, 12 (45%) were nonpalpable, 9 (33%) were single palpable nodules, and 6 (22%) were from a nodule with a suspicious ultrasound pattern within a multinodular goiter., Conclusion: Manually guided FNAB is not feasible in nonpalpable nodules and not accurate in a multinodular goiter. Both situations are clinical challenges, and USS should be performed for accurate FNAB under these circumstances. Because 52% of histologically malignant nodules in our study were found only with the aid of ultrasound-guided FNAB, this procedure should be used where multinodular goiter is endemic. Our overall rate of nondiagnostic specimens was comparable to that reported in the literature. more...
- Published
- 2002
- Full Text
- View/download PDF
38. [Pancreatic beta-cell hyperplasia in adults. A clinical case].
- Author
-
Rossi C, Grassi A, Torchio B, Ravarino N, Nasi G, Gallone G, and Fonzo D
- Subjects
- C-Peptide analysis, Diagnosis, Differential, Female, Humans, Hyperinsulinism surgery, Hyperplasia, Hypoglycemia surgery, Insulinoma diagnosis, Islets of Langerhans surgery, Middle Aged, Pancreatectomy, Pancreatic Neoplasms diagnosis, Pancreaticoduodenectomy, Hyperinsulinism etiology, Hypoglycemia etiology, Islets of Langerhans pathology
- Abstract
The author describe a rare case of pancreatic beta-cell hyperplasia. The patient was referred to us because of serious hypoglycemic crises. During hospitalization, endogenous hyperinsulinism was confirmed by hematochemical and instrumental tests. AngioCT of the pancreas evidenced a small lesion of the corpus, suspected of insulinoma. The patient underwent a corpus caudalis pancreatectomy: a small nodule with histologic neuroendocrine traits was ablated. A few days after the operation, new symptomatic hypoglycemia appeared. The hormonal tests confirmed a recurrence of endogenous hyperinsulinism. The patient underwent a new operation for pancreaticoduodenectomy: histological examination confirmed a pancreatic beta-cells hyperplasia. This condition has to be taken into account in the differential diagnosis of post prandial hypoglycemia. Besides, the observation of an insulinoma doesn't exclude the presence of a diffused disorder of islet cells as in the case above described. more...
- Published
- 1996
39. Relationships between proliferative activity and oncogene expression in human breast cancer.
- Author
-
Geuna M, Palestro G, Bianchi Malandrone L, Durando A, Demurtas A, Torchio B, and Massobrio M
- Subjects
- Aneuploidy, Breast Neoplasms genetics, Cell Division, DNA, Neoplasm genetics, Female, Flow Cytometry, Gene Expression, Humans, Immunohistochemistry, Prognosis, Proto-Oncogene Proteins c-bcl-2, Receptors, Estrogen metabolism, Receptors, Progesterone metabolism, S Phase, Breast Neoplasms metabolism, Breast Neoplasms pathology, Proto-Oncogene Proteins metabolism, Tumor Suppressor Protein p53 metabolism
- Published
- 1996
- Full Text
- View/download PDF
40. [Wegener's granulomatosis. Diagnosis and follow-up of 7 cases].
- Author
-
Manganaro M, Bruno M, Pellerito R, Ravarino N, Torchio B, Tricerri A, Gabella P, De Giovanni R, and Linari F
- Subjects
- Adult, Aged, Antibodies, Antineutrophil Cytoplasmic, Autoantibodies blood, Biomarkers, Cyclophosphamide therapeutic use, Female, Follow-Up Studies, Granulomatosis with Polyangiitis blood, Granulomatosis with Polyangiitis drug therapy, Humans, Immunosuppressive Agents therapeutic use, Male, Middle Aged, Granulomatosis with Polyangiitis diagnosis
- Abstract
Wegener's granulomatosis (WG) is a rare small vessels necrotizing and granulomatous systemic vasculitis which usually affects the respiratory-tract and the kidneys. Diagnosis is often difficult, but has become easier with antineutrophil cytoplasmic antibodies (ANCA) detection that may justify a more aggressive biopsy policy also in the elderly. Classic treatment with steroids and oral cyclophosphamide (CY) has proven to be of benefit, but side-effects are severe and frequent and the search for less toxic therapeutic schemes should be encouraged. We treated with intravenous pulses of CY (1 g/m2 monthly for 6 months, every two months for the following 6 and quarterly for another year) 5 of 7 patients with WG recently admitted to our institution. We obtained a quick, complete response in 4 of these patients, with no side effects, nor relapses, after a mean follow-up of 17 months. The only patient who did not respond was identified soon after the beginning of the treatment because of a poor reduction of ESR and could be shifted to oral administration of CY successfully. From our still limited experience CY intravenous pulses have proven to be safe and effective enough to advice its use as the first-choice treatment for WG. more...
- Published
- 1996
41. [Surgical treatment of rectal cancer: prognostic factors for long-term survival].
- Author
-
Locatelli L, Fiorentini MT, Ceccopieri B, Saracco R, Torchio B, Marchisio S, Marcomin A, and Dellepiane M
- Subjects
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Prognosis, Rectal Neoplasms mortality, Rectal Neoplasms pathology, Retrospective Studies, Survival Rate, Time Factors, Rectal Neoplasms surgery
- Abstract
The aim of our retrospective study was to verify the results of surgical treatment of rectal cancer in a homogeneous case series, evaluating the various factors that can influence the prognosis and long-term results. The prognostic factors taken into consideration were: Duke's stage; grading; colloid component; location of tumour; type of surgical intervention; age; sex; duration of the symptoms; length of normal rectum below the lower border of the tumour correlated to stage and grading. One hundred and sixty-five patients were operated with a radical approach: 50 abdominoperineal resections (APR) and 115 sphincter-saving resections (SSR) were performed. There were 90 males and 75 females. The mean age was 63 years. Total survival was 61.7% after 5 years and 50% after 10 years. In our study neither the age nor the sex, duration of symptoms or location of the tumours proved to have an influence on survival; while Duke's state turned out to be decisive for survival; also the colloid tumour component proved to have a worse prognosis. The 5-10-year survival rate was respectively 53.6% and 49% in the APR and 65.7% and 50.9% in the SSR (p = n.s.). The data we have collected show that APR and SSR operations have analogous efficiency. more...
- Published
- 1995
42. [Renal damage in rheumatoid arthritis].
- Author
-
Manganaro M, Bruno M, Ravarino N, Pellerito R, Cosseddu D, Torchio B, Urbano D, and Linari F
- Subjects
- Adult, Amyloidosis etiology, Anti-Inflammatory Agents, Non-Steroidal adverse effects, Arthritis, Rheumatoid drug therapy, Cyclosporine adverse effects, Female, Glomerulonephritis etiology, Gold adverse effects, Humans, Kidney Diseases chemically induced, Kidney Failure, Chronic chemically induced, Male, Methotrexate adverse effects, Middle Aged, Penicillamine adverse effects, Vasculitis etiology, Arthritis, Rheumatoid complications, Kidney Diseases etiology
- Abstract
Renal damage is not uncommon in rheumatoid arthritis, but the causative role of the disease per se is not well defined yet. In this paper the updated literature data are reported and our own experience as well. In particular, we describe renal syndromes associated with non-steroidal antiinflammatory drugs, remission-inducing agents (gold and penicillamine) and cytotoxic drugs, secondary amyloidosis, systemic rheumatoid vasculitis, glomerular and tubulo-interstitial nephritis not related to drug therapy. more...
- Published
- 1994
43. Surgical pathology of hepatobiliary malignancies.
- Author
-
Brisigotti M, Torchio B, Bouzari H, Capussotti L, and Callea F
- Subjects
- Adenoma, Bile Duct classification, Adenoma, Bile Duct pathology, Adenoma, Bile Duct surgery, Antigens, Viral analysis, Bile Duct Neoplasms classification, Carcinoma, Hepatocellular classification, Carcinoma, Hepatocellular complications, Hepacivirus immunology, Hepatitis B Surface Antigens analysis, Humans, Liver Cirrhosis complications, Liver Cirrhosis pathology, Liver Neoplasms classification, Liver Neoplasms complications, Neoplasm Invasiveness, Survival Rate, Bile Duct Neoplasms pathology, Bile Duct Neoplasms surgery, Bile Ducts, Intrahepatic pathology, Bile Ducts, Intrahepatic surgery, Carcinoma, Hepatocellular pathology, Carcinoma, Hepatocellular surgery, Liver Neoplasms pathology, Liver Neoplasms surgery
- Abstract
In this paper we review an Italian series of resected primary malignant tumors of the liver, with special reference to hepatocellular carcinoma, according to the classification criteria proposed by Japanese authors. The study emphasizes the presence of a thick peritumoral capsule as the main pathological feature that would indicate survival rate after surgery. more...
- Published
- 1993
- Full Text
- View/download PDF
44. Seminom cicatrice. About a case of spontaneous testicular regression.
- Author
-
Zanon C, Alluminio P, Torchio B, and Vasario E
- Subjects
- Adult, Dysgerminoma diagnostic imaging, Dysgerminoma surgery, Humans, Lymphatic Metastasis pathology, Male, Orchiectomy, Testicular Neoplasms radiotherapy, Testicular Neoplasms surgery, Tomography, X-Ray Computed, Dysgerminoma pathology, Testicular Neoplasms pathology
- Abstract
This is a case of spontaneous regression of a tumour. Only the French Authors speak about this type of seminoma called them "seminome cicatrice". Probably the immunological defences are fundamental for the complete or partial spontaneous resolution of this type of tumour. Here we describe our clinical and surgical approach. The last control was normal with a relapse-free patient. more...
- Published
- 1992
45. Abdominal fat aspiration for diagnosis of amyloidosis.
- Author
-
Manganaro M, Bruno M, Torchio B, Pellerito R, Gabella P, and Linari F
- Subjects
- Abdomen, Adipose Tissue pathology, Biopsy, Needle, Humans, Male, Middle Aged, Amyloidosis diagnosis
- Published
- 1992
- Full Text
- View/download PDF
46. FNA cytology of thyroid neurilemmoma (schwannoma)
- Author
-
Andrion A, Mazzucco G, and Torchio B
- Subjects
- Biopsy, Needle, Humans, Neurilemmoma pathology, Thyroid Neoplasms pathology
- Published
- 1992
- Full Text
- View/download PDF
47. [Liver cirrhosis and lymphoproliferative diseases: coincidence or association?].
- Author
-
Lombardo L, Rota Scalabrini D, Fracchia M, Torchio B, and De La Pierre M
- Subjects
- Adult, Aged, Cohort Studies, Female, Humans, Italy epidemiology, Liver Cirrhosis, Alcoholic complications, Lymphoproliferative Disorders epidemiology, Male, Middle Aged, Liver Cirrhosis complications, Lymphoproliferative Disorders complications
- Abstract
The development of lymphoproliferative disorders in association with a chronic liver disease, although uncommon has been documented in several reports and a review of the available literature yielded a total of 34 cases. It has been suggested that this association is probably not a fortuitous coincidence and several mechanisms explaining the development of lymphoproliferative diseases in the course of liver disease have been offered. We have evaluated the annual cumulative incidence of such an association in the specific population of patients with liver cirrhosis (N.:344) admitted to our Department of Gastroenterology, Mauriziano Hospital, in Turin, within 3.5 years, from January 1987 to June 1990: it resulted to be 9.56/1,000 subjects per year. This figure is much higher than the annual incidence registered in Turin within the years 1985-87 for the same lymphoproliferative disease, 39.6/100,000 inhabitants. Our data add value to the hypothesis that this association is not incidental and suggest that chronic liver disease should be added to the list of the pathological conditions with immunological disturbances associated with lymphoproliferative disorders. more...
- Published
- 1991
48. [Clear-cell carcinoma of the kidney in a patient with hairy-cell leukemia. Immunologic and epidemiologic considerations].
- Author
-
Buffa G, Marino G, Cocimano V, Capaldi A, and Torchio B
- Subjects
- Adenocarcinoma epidemiology, Adenocarcinoma therapy, Combined Modality Therapy, Humans, Immunologic Factors therapeutic use, Interferon Type I therapeutic use, Kidney Neoplasms epidemiology, Kidney Neoplasms therapy, Killer Cells, Natural pathology, Leukemia, Hairy Cell therapy, Male, Middle Aged, Adenocarcinoma immunology, Kidney Neoplasms immunology, Leukemia, Hairy Cell immunology, Neoplasms, Multiple Primary
- Abstract
The paper describes a case of light-cell carcinoma of the kidney in a patient affected by hairy-cell leukemia. The immunological status is assessed revealing a severe deficit of NK phenotype lymphocytes. Therapy with alpha interferon was proposed in order to stimulate killing and recruitment processes of new NK cells. more...
- Published
- 1990
49. [Endometriosis of the lower abdominal wall. Report of two cases secondary to cesarean section].
- Author
-
Bottino G, Marinello M, Menna C, Torchio B, and Vergano R
- Subjects
- Abdominal Muscles pathology, Abdominal Muscles surgery, Adult, Cicatrix pathology, Cicatrix surgery, Endometriosis pathology, Endometriosis surgery, Female, Granuloma, Foreign-Body pathology, Granuloma, Foreign-Body surgery, Humans, Postoperative Complications, Pregnancy, Skin Neoplasms pathology, Skin Neoplasms surgery, Sutures adverse effects, Cesarean Section adverse effects, Endometriosis etiology, Skin Neoplasms etiology
- Abstract
The paper describes two cases of cutaneous endometriosis in correspondence with the surgical scar following cesarean section. The cases formed part of a series of 500 abdominal operations performed during the period 1988-89, of which about 200 were cesarean sections, with a 1% frequency. In line with the hypothesis regarding the spread of endometrial tissue during surgery and with that concerning peritoneal metaplasia, the authors recommend paying special attention during the technical procedure of extracting the fetus, and performing an introflexed suture of the uterine incision and of the parietal peritoneum. more...
- Published
- 1990
50. [Description of a case of diffuse gastric polyposis].
- Author
-
Robera L, Babando GM, and Torchio B
- Subjects
- Aged, Female, Gastroscopy, Humans, Polyps pathology, Stomach Neoplasms pathology, Polyps diagnosis, Stomach Neoplasms diagnosis
- Published
- 1981
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.