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1. Overweight and erythrocyte polyunsaturated fatty acid changes in menopause

Author

D’Alberti Giulia, Ferreri Carla, Larocca Anna Vita, Torquato Pierangelo, Boccuto Antonio, Gizzi Chiara, and Albi Elisabetta

Subjects
menopause, bmi, lipidomic, fatty acids, omega 6, omega 3, Biotechnology, TP248.13-248.65
Abstract

Lipid disorders have been implicated in overweight and menopause. However, evidence on lipidomic analysis of fatty acids in erythrocytes of menopausal women is scarce. The aim of this study was to investigate the relationship between the body mass index within or beyond 5 years of menopause and erythrocyte fatty acid profile. This case-control study was conducted on out of 37 menopausal women total patients, 22 with body mass index ≥ 25 and 12 matched controls (body mass index 25 and non-physiological content of fatty acids, were richer in percentage of saturated fatty acids and poorer of monounsaturated fatty acids and polyunsaturated fatty acids than women with BMI25 than in women with BMI

Published
2020
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4. Vitamin E: metabolism and molecular aspects

Author

Torquato, Pierangelo, primary, Marinelli, Rita, additional, Bartolini, Desirée, additional, Giusepponi, Danilo, additional, Cruciani, Gabriele, additional, Siragusa, Lydia, additional, Galarini, Roberta, additional, Sebastiani, Bartolomeo, additional, Gioiello, Antimo, additional, and Galli, Francesco, additional

Published
2020
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5. List of Contributors

Author

Aghi, Andrea, primary, Akdad, Mourad, additional, Andres, Emmanuel, additional, Bartolini, Desirée, additional, Brandão, Paula, additional, Bridges, Allison, additional, Casanello, Paola, additional, Castaño-Moreno, Erika, additional, Chailyan, S.G., additional, Ciceri, Paola, additional, Conte, Ferruccio, additional, Cozzolino, Mario, additional, Cruciani, Gabriele, additional, Cunningham, John, additional, Dali-Youcef, Nassim, additional, Dalto, Danyel Bueno, additional, Danielyan, K.E., additional, De Santis, Domenica, additional, Dontaraju, Venkata Satish, additional, Dronamraju, Venkateshwara, additional, El Bouhali, Bachir, additional, Emmerson, Joshua T., additional, Fichna, Jakub, additional, Friso, Simonetta, additional, Fusaro, Maria, additional, Galarini, Roberta, additional, Galassi, Andrea, additional, Galli, Francesco, additional, Gallieni, Maurizio, additional, Geier, Andreas, additional, Gioiello, Antimo, additional, Giusepponi, Danilo, additional, Gomes, Cláudio M., additional, Gonçalves, Álisson de Carvalho, additional, Guieu, Samuel, additional, Hagiwara, Shin-ichiro, additional, Hajiluian, Ghazaleh, additional, Henriques, Bárbara J., additional, Iervasi, Giorgio, additional, Jadavji, Nafisa M., additional, Jahn, Daniel, additional, Jankowska, Magdalena, additional, Karmin, O, additional, Kato, Norihisa, additional, Khallouki, Farid, additional, Kruk, Jerzy, additional, Kumrungsee, Thanutchaporn, additional, Labudzinskyi, Dmytro, additional, Laganà, Antonio Simone, additional, Lisakovska, Olha, additional, Llanos, Miguel, additional, Locatelli, Francesco, additional, Marinelli, Rita, additional, Matte, Jean-Jacques, additional, Mazanova, Anna, additional, Mereu, Maria Cristina, additional, Millan-Linares, Maria C., additional, Moftah, Mahira, additional, Montserrat-de la Paz, Sergio, additional, Munirathinam, Gnanasekar, additional, Mustafi, Sushmita, additional, Mutalip, Siti Syairah Mohd, additional, Naranjo, Maria C., additional, Nowicka, Beatrycze, additional, Owen, Robert Wyn, additional, Parkhomenko, Yuliya, additional, Peñailillo, Reyna, additional, Piñuñuri, Raúl, additional, Pizzolo, Francesca, additional, Plebani, Mario, additional, Poirot, Marc, additional, Portari, Guilherme Vannucchi, additional, Prasad, Puttur D., additional, Preedy, Victor R., additional, Price, Mina Yamazaki, additional, Protasova, Zoya, additional, Rajpurohit, Pragya, additional, Rizzo, Gianluca, additional, Ronco, Ana María, additional, Sebastiani, Bartolomeo, additional, Shidfar, Farzad, additional, Shymanskyi, Ihor, additional, Sid, Victoria, additional, Silvente-Poirot, Sandrine, additional, Siow, Yaw L., additional, Siragusa, Lydia, additional, Soldi, Luiz Ricardo, additional, Stucchi, Andrea, additional, Suda, Takashi, additional, Suidasari, Sofya, additional, Sylvester, Paul William, additional, Szymaszkiewicz, Agata, additional, Szymańska, Renata, additional, Thakur, Kiran, additional, Thangaraju, Muthusamy, additional, Tomar, Sudhir Kumar, additional, Torquato, Pierangelo, additional, Trela, Agnieszka, additional, Tripepi, Giovanni, additional, Udali, Silvia, additional, Veliky, Mykola, additional, Vinjamuri, Smita, additional, Vovk, Andriy, additional, Wang, Gaofeng, additional, Wei, Zhao-Jun, additional, Woo, Connie W.H., additional, Yanaka, Noriyuki, additional, Zaninotto, Martina, additional, Zhang, Peipei, additional, and Świerczyński, Mikołaj, additional

Published
2020
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10. Neurobiological Correlates of Alpha-Tocopherol Antiepileptogenic Effects and MicroRNA Expression Modulation in a Rat Model of Kainate-Induced Seizures

Author

Ambrogini, Patrizia, Albertini, Maria Cristina, Betti, Michele, Galati, Claudia, Lattanzi, Davide, Savelli, David, Di Palma, Michael, Saccomanno, Stefania, Bartolini, Desirée, Torquato, Pierangelo, Ruffolo, Gabriele, Olivieri, Fabiola, Galli, Francesco, Palma, Eleonora, Minelli, Andrea, and Cuppini, Riccardo

Published
2018
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13. Selenium and Cancer Stem Cells

Author

Murdolo, Giuseppe, primary, Bartolini, Desirée, additional, Tortoioli, Cristina, additional, Piroddi, Marta, additional, Torquato, Pierangelo, additional, and Galli, Francesco, additional

Published
2017
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15. High molecular weight uremic retention solutes stimulate GSTP protein expression and oxidative damage of peripheral blood leukocytes

Author

Bartolini, Desirée, primary, Stabile, Anna Maria, additional, Grignano, Maria Antonietta, additional, Focaia, Riccardo, additional, Torquato, Pierangelo, additional, Di Cristina, Manlio, additional, Piro, Federica, additional, Rende, Mario, additional, Libetta, Carmelo, additional, and Galli, Francesco, additional

Published
2021
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16. Garcinoic acid prevents β-amyloid (Aβ) deposition in the mouse brain

Author

Marinelli, Rita, primary, Torquato, Pierangelo, additional, Bartolini, Desirée, additional, Mas-Bargues, Cristina, additional, Bellezza, Guido, additional, Gioiello, Antimo, additional, Borras, Consuelo, additional, De Luca, Antonella, additional, Fallarino, Francesca, additional, Sebastiani, Bartolomeo, additional, Mani, Sridhar, additional, Sidoni, Angelo, additional, Viña, Jose, additional, Leri, Manuela, additional, Bucciantini, Monica, additional, Nardiello, Pamela, additional, Casamenti, Fiorella, additional, and Galli, Francesco, additional

Published
2020
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17. Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor

Author

Bartolini, Desirée, primary, De Franco, Francesca, additional, Torquato, Pierangelo, additional, Marinelli, Rita, additional, Cerra, Bruno, additional, Ronchetti, Riccardo, additional, Schon, Arne, additional, Fallarino, Francesca, additional, De Luca, Antonella, additional, Bellezza, Guido, additional, Ferri, Ivana, additional, Sidoni, Angelo, additional, Walton, William G., additional, Pellock, Samuel J., additional, Redinbo, Matthew R., additional, Mani, Sridhar, additional, Pellicciari, Roberto, additional, Gioiello, Antimo, additional, and Galli, Francesco, additional

Published
2020
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18. Physical Activity Modulates the Overexpression of the Inflammatory miR-146a-5p in Obese Patients

Author

Russo, Angelo, Bartolini, Desireé, Mensà, Emanuela, Torquato, Pierangelo, Albertini, Maria Cristina, Olivieri, Fabiola, Testa, Roberto, Rossi, Sara, Piroddi, Marta, Cruciani, Gabriele, De Feo, Pierpaolo, and Galli, Francesco

Subjects
inflammation, lipid metabolism, metabolic syndrome, microRNA, obesity, physical activity, training exercise, Biochemistry, Molecular Biology, Genetics, Clinical Biochemistry, Cell Biology, Inflammation, Male, Metabolic Syndrome, Tumor Necrosis Factor-alpha, NF-kappa B, Middle Aged, Lipid Metabolism, MicroRNAs, Humans, Female, Obesity, Exercise, Biomarkers, Aged
Abstract

Specific microRNAs (miRs), including the "angio-miR-126" and the "inflamma-miR-146a-5p," have been proposed as biomarkers and even therapeutic targets of obesity-associated metabolic diseases. Physical activity, a key measure of prevention for obesity and its complications, is reported to influence the expression of these miRs. In this study, we investigate whether a physical activity program proven to improve metabolic parameters in obese patients can correct the circulating levels of these miRs. Plasma miR-126 and miR-146a-5p were measured in a cohort of obese patients (n = 31, 16F + 15M) before and after the 3-month physical activity program of the CURIAMO trial (registration number for clinical trials: ACTRN12611000255987) and in 37 lean controls (24F + 13M). miR-146a-5p, but not miR-126, was significantly increased in obese patients as compared with lean controls and decreased in approximately two-thirds of the participants post-intervention with a response that positively correlated with pre-intervention levels of this miR. Waist circumference, the inflammatory cytokine IL-8 and lipid parameters, principally total cholesterol, showed the strongest correlation with both the baseline levels and post-intervention correction of miR-146a-5p. Post-hoc analysis of experimental data supports the use of miR-146a-5p as a biomarker and predictor of the clinical response to physical activity in obese patients. Furthermore, miR-146a-5p expression was confirmed to increase together with that of the inflammatory genes TLR4, NF-κB, IL-6, and TNF-α in LPS-stimulated human mononuclear leukocytes. In conclusion, the inflamma-miR-146a-5p can serve as a personalized predictor of clinical outcome in obese patients entering physical activity weight-reduction programs. © 2018 IUBMB Life, 70(10):1012-1022, 2018.

Published
2018

19. Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor

Author

Bartolini, Desirée, primary, De Franco, Francesca, primary, Torquato, Pierangelo, primary, Marinelli, Rita, primary, Cerra, Bruno, primary, Ronchetti, Riccardo, primary, Schön, Arne, primary, Fallarino, Francesca, primary, De Luca, Antonella, primary, Bellezza, Guido, primary, Ferri, Ivana, primary, Sidoni, Angelo, primary, Walton, William G., primary, Pellock, Samuel J., primary, Redinbo, Matthew R., primary, Mani, Sridhar, primary, Pellicciari, Roberto, primary, Gioiello, Antimo, primary, and Galli, Francesco, primary

Published
2019
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20. LC-MS/MS assay for the simultaneous determination of tocopherols, polyunsaturated fatty acids and their metabolites in human plasma and serum

Author

Giusepponi, Danilo, primary, Galarini, Roberta, additional, Barola, Carolina, additional, Torquato, Pierangelo, additional, Bartolini, Desirée, additional, Moretti, Simone, additional, Saluti, Giorgio, additional, Gioiello, Antimo, additional, Libetta, Carmelo, additional, and Galli, Francesco, additional

Published
2019
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25. Physical Activity Modulates the Overexpression of the Inflammatory miR-146a-5p in Obese Patients

Author

Russo, Angelo, primary, Bartolini, Desireé, additional, Mensà, Emanuela, additional, Torquato, Pierangelo, additional, Albertini, Maria Cristina, additional, Olivieri, Fabiola, additional, Testa, Roberto, additional, Rossi, Sara, additional, Piroddi, Marta, additional, Cruciani, Gabriele, additional, De Feo, Pierpaolo, additional, and Galli, Francesco, additional

Published
2018
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28. Glutathione S-transferase P influences the Nrf2-dependent control of cellular glutathione metabolism

Author

Rossi Ranieri, Giustarini Daniela, Bartolini Desirée, Pietrella Donatella, Marinelli Rita, Torquato Pierangelo, and Galli Francesco

Subjects
chemistry.chemical_compound, Biosynthesis, Chemistry, Apoptosis, Physiology (medical), Secretion, Glutathione, Metabolism, Protein glutathionylation, Biochemistry, Redox, Gene, Cell biology
Abstract

Glutathione-S-transferase P-1 (GSTP) was recently proposed to interact with Nrf2 thus regulating its transcriptional activity. The possible consequences of such functional interaction on the metabolism and redox of cellular GSH remain unexplored and were investigated for the first time in this study using both genetic and pharmacological manipulation models of GSTP in murine embryonic fibroblasts (MEFs). The GSTP-/- genotype was associated with a higher nuclear translocation of Nrf2 and apoptotic signaling of MEFs, and then with a marked increase of Cys uptake that resulted in a higher de novo biosynthesis and secretion of cellular GSH. Se-organic compounds (SOC) further stimulated these responses with a potency that correlated with the thiol peroxidase activity of the compounds. A defective expression of GSTP and SOC treatments also influenced the oxidation of GSH to GSSG and protein glutathionylation (PSSG) that was confirmed to be a GSTP-dependent process. The transient manipulation of Nrf2 gene interfered with the SOC-stimulated synthesis and secretion of GSH in the GSTP-/- aplotype, but not in GSTP+/+ cells. In conclusion, the GSTP-Nrf2 interaction strongly influences the metabolism and redox-signaling function of cellular GSH.

Published
2018
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29. Nonalcoholic fatty liver disease impairs the cytochrome P-450-dependent metabolism of α-tocopherol (vitamin E)

Author

Bartolini, Desirée, primary, Torquato, Pierangelo, additional, Barola, Carolina, additional, Russo, Angelo, additional, Rychlicki, Chiara, additional, Giusepponi, Danilo, additional, Bellezza, Guido, additional, Sidoni, Angelo, additional, Galarini, Roberta, additional, Svegliati-Baroni, Gianluca, additional, and Galli, Francesco, additional

Published
2017
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31. Alpha-(13′-hydroxy)-6-hydroxychroman, the main product of alpha-tocopherol metabolism in human hepatocytes, regulates CYP4F2 and PPAR-γ expression

Author

Torquato, Pierangelo, primary, Bartolini, Desirée, additional, Giusepponi, Danilo, additional, Saluti, Giorgio, additional, Galarini, Roberta, additional, Russo, Angelo, additional, Birringer, Mark, additional, Lorkowski, Stefan, additional, Consuelo, Borras, additional, Viña, Josè, additional, and Galli, Francesco, additional

Published
2017
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32. A quantitiative LC-MS/MS method for the measurement of tocopherols, polyinsaturated fatty acids and their metabolites in human plasma and serum

Author

Giusepponi, Danilo, primary, Torquato, Pierangelo, additional, Bartolini, Desirée, additional, Piroddi, Marta, additional, Moretti, Simone, additional, Saluti, Giorgio, additional, Birringer, Mark, additional, Lorkowski, Stefan, additional, Galli, Francesco, additional, and Galarini, Roberta, additional

Published
2017
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33. Glutathione compartmentalization and its role in glutathionylation and other regulatory processes of cellular pathways.

Author

Scirè, Andrea, Cianfruglia, Laura, Minnelli, Cristina, Bartolini, Desirée, Torquato, Pierangelo, Principato, Giovanni, Galli, Francesco, and Armeni, Tatiana

Subjects
CELL compartmentation, GLUTATHIONE, CELL cycle regulation, REDUCING agents, MOLECULAR weights, AMINO acids
Abstract

Glutathione is considered the major non‐protein low molecular weight modulator of redox processes and the most important thiol reducing agent of the cell. The biosynthesis of glutathione occurs in the cytosol from its constituent amino acids, but this tripeptide is also present in the most important cellular districts, such as mitochondria, nucleus, and endoplasmic reticulum, thus playing a central role in several metabolic pathways and cytoprotection mechanisms. Indeed, glutathione is involved in the modulation of various cellular processes and, not by chance, it is a ubiquitous determinant for redox signaling, xenobiotic detoxification, and regulation of cell cycle and death programs. The balance between its concentration and redox state is due to a complex series of interactions between biosynthesis, utilization, degradation, and transport. All these factors are of great importance to understand the significance of cellular redox balance and its relationship with physiological responses and pathological conditions. The purpose of this review is to give an overview on glutathione cellular compartmentalization. Information on its subcellular distribution provides a deeper understanding of glutathione‐dependent processes and reflects the importance of compartmentalization in the regulation of specific cellular pathways. © 2018 BioFactors, 45(2):152–168, 2019 [ABSTRACT FROM AUTHOR]

Published
2019
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34. Analytical and molecular insights in the cytochrome P450 metabolism of vitamin E and lipotoxicity mechanisms of non-alcoholic fatty liver

Author

Rychlicki Chiara, Galarini Roberta, Torquato Pierangelo, Pierantonelli Irene, Svegliati-Baroni Gianluca, Galli Francesco, Ripa Orsola, Barola Carolina, and Desirée Bartolini

Subjects
0301 basic medicine, biology, Chemistry, Vitamin E, medicine.medical_treatment, Fatty liver, Cytochrome P450, Non alcoholic, Metabolism, medicine.disease, Biochemistry, 03 medical and health sciences, 030104 developmental biology, Lipotoxicity, Physiology (medical), medicine, biology.protein
Published
2016
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40. Human serum determination and in vitro anti-inflammatory activity of the vitamin E metabolite α-(13'-hydroxy)-6-hydroxychroman

Author

Ciffolilli, Silvia, primary, Wallert, Maria, additional, Bartolini, Desirée, additional, Krauth, Verena, additional, Werz, Oliver, additional, Piroddi, Marta, additional, Sebastiani, Bartolomeo, additional, Torquato, Pierangelo, additional, Lorkowski, Stefan, additional, Birringer, Marc, additional, and Galli, Francesco, additional

Published
2015
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45. YI-11 - a-13'-OH is the main product of a-tocopherol metabolism and influences CYP4F2 and PPAR? gene expression in HepG2 human hepatocarcinoma cells.

Author

Torquato, Pierangelo, Bartolini, Desire, Giusepponi, Danilo, Saluti, Giorgio, Russo, Angelo, Barola, Carolina, Birringer, Marc, Galarini, Roberta, and Galli, Francesco

Subjects
*LIVER cancer, *CYTOCHROME P-450, *VITAMIN metabolism, *PEROXISOME proliferator-activated receptors, *VITAMIN E, *GENE expression, *GENETICS
Published
2016
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48. PP68 - Cytochrome P450 metabolism of vitamin E in models of non-alcoholic fatty liver disease and steatohepatitis.

Author

Bartolini, Desirée, Faccani, Veronica, Russo, Angelo, Pieri, Vanessa, Torquato, Pierangelo, Agostinelli, Laura, Rychlicki, Chiara, Svegliati-Baroni, Gianluca, and Galli, Francesco

Subjects
*CYTOCHROME P-450, *FATTY liver, *VITAMIN E, *INFLAMMATION, *LIVER cancer, *ANTIOXIDANTS
Abstract

Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease worldwide in association with oxidative stress and insulin resistance. Steatosis can evolve to steatohepatitis (NASH) by lipotoxicity, inflammation, fibrosis and cell death leading to cirrhosis and hepatocellular carcinoma. No valid therapy has been developed so far to control inflammatory and fibrogenic pathways of NAFLD/NASH. α-Tocopherol (α-TOH) is an antioxidant that partially reverts the histopatological spectrum of NASH. However, the biological mechanism that may support a preventive or therapeutic role of vitamin E in NASH and chronic liver diseases remain elusive. In this study we explored in vitro and in vivo the metabolism of vitamin E in liver cells and in the whole liver exposed to some pathogenic stimuli associated with the progression of NAFLD/NASH. Protein levels of CYP4F2, the cytochrome P450 isoenzyme involved in the metabolism of vitamin E increased in HepG2 cells incubated with α-TOH. This effect increased with a synergic action by the treatment with the fatty acids oleic acid or palmitic acid, or with fructose, which are well-known NASH stimuli. In mice fed control or NAFLD/NASH diets, e.g. high-fat (HFD) or HFD plus fructose diet, the abnormal lipid metabolism of liver tissue was associated with a lowered expression of CYP4F2 protein. The same finding was observed in animals treated with CCl4, a free radical-generating hepatotoxic xenobiotic leading to hepatic fibrosis, in the presence of lowered levels of liver α-TOH. In conclusion, either acute or chronic challenges with NAFLD/NASH stimuli influence the liver expression of CYP4F2. The observed acute transcriptional upregulation and the in vivo downregulation of this protein, point to a role for CYP4F2 in the inflammatory and lipotoxicity signaling of NASH. Transcriptional effects of vitamin E on this gene may help to explain earlier and positive clinical findings, which are worth of further investigation. [ABSTRACT FROM AUTHOR]

Published
2015
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49. Selenium and Cancer Stem Cells.

Author

Murdolo G, Bartolini D, Tortoioli C, Piroddi M, Torquato P, and Galli F

Subjects
Animals, Carcinogenesis drug effects, Cell Differentiation drug effects, Humans, Neoplasms drug therapy, Neoplasms prevention & control, Oxidation-Reduction drug effects, Signal Transduction drug effects, Neoplastic Stem Cells drug effects, Selenium pharmacology, Selenium therapeutic use
Abstract

Selenium (Se) is an essential micronutrient that functions as "redox gatekeeper" and homeostasis factor of normal and cancer cells. Epidemiology and experimental studies, in the last years suggested that both inorganic and organic forms of Se may have favorable health effects. In this regard, a protective action of Se on cellular systems that may help preventing cancer cell differentiation has been demonstrated, while the hypothesis that Se compounds may cure cancer and its metastatic diffusion appears speculative and is still a matter of investigation. Indeed, the overall actions of Se compounds in carcinogenesis are controversial. The recognition that cancer is a stem cell disease instigated major paradigm shifts in our basic understanding of cancer and attracted a great deal of interest. Although current treatment approaches in cancer are grounded in the need to kill the majority of cancer cells, targeting cancer stem cells (CSCs) may hold great potential in improving cancer treatment. In this respect, Se compounds have been demonstrated modulating numerous signaling pathways involved in CSC biology and these findings are now stimulating further research on optimal Se concentrations, most effective and cancer-specific Se compounds, and inherent pathways involved in redox and metabolic regulation of CSCs. In this review, we summarize the current knowledge about the effects of Se compounds on CSCs, by focusing on redox-dependent pathways and main gene regulation checkpoints that affect self-renewal, differentiation, and migration responses in this subpopulation of cancer cells., (© 2017 Elsevier Inc. All rights reserved.)

Published
2017
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