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2. Case report: Neuronal intranuclear inclusion disease presenting with acute encephalopathy.

Author

Bu, Julia Ting, Torres, Dolores, Robinson, Adam, Malone, Corey, Vera, Juan Carlos, Daghighi, Shadi, Dunn-Pirio, Anastasie, Khoromi, Suzan, Nowell, Justin, Léger, Gabriel C, Ciacci, Joseph D, Goodwill, Vanessa S, Estrella, Melanie, Coughlin, David G, Guo, Yueyang, and Farid, Nikdokht

Subjects
arterial spin labeling, case report, chromatolysis, magnetic resonance imaging, neuronal intranuclear inclusion disease, Clinical Research, Neurodegenerative, Neurosciences, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Clinical Sciences, Psychology
Abstract

Neuronal intranuclear inclusion disease (NIID), a neurodegenerative disease previously thought to be rare, is increasingly recognized despite heterogeneous clinical presentations. NIID is pathologically characterized by ubiquitin and p-62 positive intranuclear eosinophilic inclusions that affect multiple organ systems, including the brain, skin, and other tissues. Although the diagnosis of NIID is challenging due to phenotypic heterogeneity, a greater understanding of the clinical and imaging presentations can improve accurate and early diagnosis. Here, we present three cases of pathologically proven adult-onset NIID, all presenting with episodes of acute encephalopathy with protracted workups and lengthy time between symptom onset and diagnosis. Case 1 highlights challenges in the diagnosis of NIID when MRI does not reveal classic abnormalities and provides a striking example of hyperperfusion in the setting of acute encephalopathy, as well as unique pathology with neuronal central chromatolysis, which has not been previously described. Case 2 highlights the progression of MRI findings associated with multiple NIID-related encephalopathic episodes over an extended time period, as well as the utility of skin biopsy for antemortem diagnosis.

Published
2023

5. Topological network analysis of patient similarity for precision management of acute blood pressure in spinal cord injury

Author

Torres-Espín, Abel, Haefeli, Jenny, Ehsanian, Reza, Torres, Dolores, Almeida, Carlos A, Huie, J Russell, Chou, Austin, Morozov, Dmitriy, Sanderson, Nicole, Dirlikov, Benjamin, Suen, Catherine G, Nielson, Jessica L, Kyritsis, Nikos, Hemmerle, Debra D, Talbott, Jason F, Manley, Geoffrey T, Dhall, Sanjay S, Whetstone, William D, Bresnahan, Jacqueline C, Beattie, Michael S, McKenna, Stephen L, Pan, Jonathan Z, Ferguson, Adam R, Beattie, Bresnahan, JC, Burke, JF, Chou, A, de Almeida, CA, Dhall, SS, DiGiorgio, AM, Doung-Fernandez, X, Ferguson, AR, Haefeli, J, Hemmerle, DD, Huie, Kyritsis, N, Manley, GT, Moncivais, S, Omondi, C, Pan, JZ, Pascual, LU, Singh, V, Talbott, JF, Thomas, LH, Torres-Espin, A, Weinstein, P, and Whetstone, WD

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Spinal Cord Injury, Traumatic Head and Spine Injury, Neurosciences, Physical Injury - Accidents and Adverse Effects, Neurological, Adult, Aged, Aged, 80 and over, Arterial Pressure, Blood Pressure, Humans, Middle Aged, Monitoring, Intraoperative, Recovery of Function, Retrospective Studies, Spinal Cord Injuries, topological networks analysis, spinal cord injury, blood pressure, machine learning, surgery, Human, TRACK-SCI Investigators, computational biology, human, medicine, systems biology, Biochemistry and Cell Biology, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundPredicting neurological recovery after spinal cord injury (SCI) is challenging. Using topological data analysis, we have previously shown that mean arterial pressure (MAP) during SCI surgery predicts long-term functional recovery in rodent models, motivating the present multicenter study in patients.MethodsIntra-operative monitoring records and neurological outcome data were extracted (n = 118 patients). We built a similarity network of patients from a low-dimensional space embedded using a non-linear algorithm, Isomap, and ensured topological extraction using persistent homology metrics. Confirmatory analysis was conducted through regression methods.ResultsNetwork analysis suggested that time outside of an optimum MAP range (hypotension or hypertension) during surgery was associated with lower likelihood of neurological recovery at hospital discharge. Logistic and LASSO (least absolute shrinkage and selection operator) regression confirmed these findings, revealing an optimal MAP range of 76-[104-117] mmHg associated with neurological recovery.ConclusionsWe show that deviation from this optimal MAP range during SCI surgery predicts lower probability of neurological recovery and suggest new targets for therapeutic intervention.FundingNIH/NINDS: R01NS088475 (ARF); R01NS122888 (ARF); UH3NS106899 (ARF); Department of Veterans Affairs: 1I01RX002245 (ARF), I01RX002787 (ARF); Wings for Life Foundation (ATE, ARF); Craig H. Neilsen Foundation (ARF); and DOD: SC150198 (MSB); SC190233 (MSB).

Published
2021

7. Correction: Exploration of surgical blood pressure management and expected motor recovery in individuals with traumatic spinal cord injury.

Author

Ehsanian, Reza, Haefeli, Jenny, Quach, Nhung, Kosarchuk, Jacob, Torres, Dolores, Stuck, Ellen D, Endo, Jessica, Crew, James D, Dirlikov, Benjamin, Bresnahan, Jacqueline C, Beattie, Michael S, Ferguson, Adam R, and McKenna, Stephen L

Subjects
Clinical Sciences, Human Movement and Sports Sciences, Neurosciences, Rehabilitation
Abstract

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Published
2020

8. Exploration of surgical blood pressure management and expected motor recovery in individuals with traumatic spinal cord injury.

Author

Ehsanian, Reza, Haefeli, Jenny, Quach, Nhung, Kosarchuk, Jacob, Torres, Dolores, Stuck, Ellen D, Endo, Jessica, Crew, James D, Dirlikov, Benjamin, Bresnahan, Jacqueline C, Beattie, Michael S, Ferguson, Adam R, and McKenna, Stephen L

Subjects
Humans, Spinal Cord Injuries, Blood Pressure Determination, Monitoring, Intraoperative, Retrospective Studies, Recovery of Function, Time Factors, Adult, Middle Aged, Female, Male, Arterial Pressure, Neurodegenerative, Physical Rehabilitation, Patient Safety, Spinal Cord Injury, Clinical Research, Injury - Trauma - (Head and Spine), Rehabilitation, Injury (total) Accidents/Adverse Effects, Neurosciences, Injuries and accidents, Clinical Sciences, Human Movement and Sports Sciences
Abstract

Study designRetrospective analysis.ObjectiveTo assess the impact of mean arterial blood pressure (MAP) during surgical intervention for spinal cord injury (SCI) on motor recovery.SettingLevel-one Trauma Hospital and Acute Rehabilitation Hospital in San Jose, CA, USA.MethodsTwenty-five individuals with traumatic SCI who received surgical and acute rehabilitation care at a level-one trauma center were included in this study. The Surgical Information System captured intraoperative MAPs on a minute-by-minute basis and exposure was quantified at sequential thresholds from 50 to 104 mmHg. Change in International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) motor score was calculated based on physiatry evaluations at the earliest postoperative time and at discharge from acute rehabilitation. Linear regression models were used to estimate the rate of recovery across the entire MAP range.ResultsAn exploratory analysis revealed that increased time within an intraoperative MAP range (70-94 mmHg) was associated with ISNCSCI motor score improvement. A significant regression equation was found for the MAP range 70-94 mmHg (F[1, 23] = 5.07, r2 = 0.181, p = 0.034). ISNCSCI motor scores increased 0.039 for each minute of exposure to the MAP range 70-94 mmHg during the operative procedure; this represents a significant correlation between intraoperative time with MAP 70-94 and subsequent motor recovery. Blood pressure exposures above or below this range did not display a positive association with motor recovery.ConclusionsHypertension as well as hypotension during surgery may impact the trajectory of recovery in individuals with SCI, and there may be a direct relationship between intraoperative MAP and motor recovery.

Published
2020

17. Case report: Neuronal intranuclear inclusion disease presenting with acute encephalopathy

Author

Bu, Julia Ting, primary, Torres, Dolores, additional, Robinson, Adam, additional, Malone, Corey, additional, Vera, Juan Carlos, additional, Daghighi, Shadi, additional, Dunn-Pirio, Anastasie, additional, Khoromi, Suzan, additional, Nowell, Justin, additional, Léger, Gabriel C., additional, Ciacci, Joseph D., additional, Goodwill, Vanessa S., additional, Estrella, Melanie, additional, Coughlin, David G., additional, Guo, Yueyang, additional, and Farid, Nikdokht, additional

Published
2023
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21. Supplementary Figures from Intracellular Delivery of an Antibody Targeting Gasdermin-B Reduces HER2 Breast Cancer Aggressiveness

Author

Molina-Crespo, Ángela, primary, Cadete, Ana, primary, Sarrio, David, primary, Gámez-Chiachio, Manuel, primary, Martinez, Lidia, primary, Chao, Kinlin, primary, Olivera, Ana, primary, Gonella, Andrea, primary, Díaz, Eva, primary, Palacios, José, primary, Dhal, Pradeep K., primary, Besev, Magnus, primary, Rodríguez-Serrano, Macarena, primary, García Bermejo, María Laura, primary, Triviño, Juan Carlos, primary, Cano, Amparo, primary, García-Fuentes, Marcos, primary, Herzberg, Osnat, primary, Torres, Dolores, primary, Alonso, Maria José, primary, and Moreno-Bueno, Gema, primary

Published
2023
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22. Supplementary Methods from Intracellular Delivery of an Antibody Targeting Gasdermin-B Reduces HER2 Breast Cancer Aggressiveness

Author

Molina-Crespo, Ángela, primary, Cadete, Ana, primary, Sarrio, David, primary, Gámez-Chiachio, Manuel, primary, Martinez, Lidia, primary, Chao, Kinlin, primary, Olivera, Ana, primary, Gonella, Andrea, primary, Díaz, Eva, primary, Palacios, José, primary, Dhal, Pradeep K., primary, Besev, Magnus, primary, Rodríguez-Serrano, Macarena, primary, García Bermejo, María Laura, primary, Triviño, Juan Carlos, primary, Cano, Amparo, primary, García-Fuentes, Marcos, primary, Herzberg, Osnat, primary, Torres, Dolores, primary, Alonso, Maria José, primary, and Moreno-Bueno, Gema, primary

Published
2023
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28. Abstract WP45: VISIION-S: Viz.ai Implementation Of Stroke Augmented Intelligence And Communications Platform To Improve Indicators And Outcomes For A Comprehensive Stroke Center And Network - Sustainability

Author

Van Orden, Kimberlee, primary, Meyer, Dawn M, additional, Perrinez, Emily, additional, Poynor, Briana, additional, Torres, Dolores, additional, Alwood, Benjamin, additional, Bykowski, Julie, additional, Khalessi, Alexander A, additional, and Meyer, Brett C, additional

Published
2023
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31. Nuclear Cardiology

Author

Jiménez-Hoyuela García, José Manuel, Lozano, Simeón Ortega, Torres, Dolores Martínez del Valle, Cardo, Antonio Guitiérrez, Moreno, Esperanza Ramos, Ribes, R., editor, Kuschnir, P., editor, Luna, A., editor, Vilanova, J. C., editor, and Jimenez-Hoyuela, J. M., editor

Published
2010
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33. Hybridization of Evolutionary Mechanisms for Feature Subset Selection in Unsupervised Learning

Author

Torres, Dolores, Ponce-de-León, Eunice, Torres, Aurora, Ochoa, Alberto, Díaz, Elva, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Goebel, Randy, editor, Siekmann, Jörg, editor, Wahlster, Wolfgang, editor, Aguirre, Arturo Hernández, editor, Borja, Raúl Monroy, editor, and Garciá, Carlos Alberto Reyes, editor

Published
2009
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39. Nanotechnologies for the delivery of biologicals: Historical perspective and current landscape

Author

Universidad de Sevilla. Departamento de Farmacia y Tecnología Farmacéutica, Ministerio de Ciencia, Innovación y Universidades (MICINN). España, Xunta de Galicia, Agencia Estatal de Investigación. España, Durán Lobato, María Matilde, López Estévez, Ana María, Cordeiro, Ana Sara, Dacoba, Tamara G., Crecente Campo, José, Torres, Dolores, Alonso, María José, Universidad de Sevilla. Departamento de Farmacia y Tecnología Farmacéutica, Ministerio de Ciencia, Innovación y Universidades (MICINN). España, Xunta de Galicia, Agencia Estatal de Investigación. España, Durán Lobato, María Matilde, López Estévez, Ana María, Cordeiro, Ana Sara, Dacoba, Tamara G., Crecente Campo, José, Torres, Dolores, and Alonso, María José

Abstract

Biological macromolecule-based therapeutics irrupted in the pharmaceutical scene generating a great hope due to their outstanding specificity and potency. However, given their susceptibility to degradation and limited capacity to overcome biological barriers new delivery technologies had to be developed for them to reach their targets. This review aims at analyzing the historical seminal advances that shaped the development of the protein/peptide delivery field, along with the emerging technologies on the lead of the current landscape. Particularly, focus is made on technologies with a potential for transmucosal systemic delivery of protein/peptide drugs, followed by approaches for the delivery of antigens as new vaccination strategies, and formulations of biological drugs in oncology, with special emphasis on mAbs. Finally, a discussion of the key challenges the field is facing, along with an overview of prospective advances are provided.

Published
2021

40. A nanoemulsion/micelles mixed nanosystem for the oral administration of hydrophobically modified insulin.

Author

UCL - SSS/LDRI - Louvain Drug Research Institute, Santalices, Irene, Vázquez-Vázquez, Carlos, Santander-Ortega, Manuel J, Lozano, Victoria, Araújo, Francisca, Sarmento, Bruno, Shrestha, Neha, Préat, Véronique, Chenlo, Miguel, Alvarez, Clara V, Benetti, Federico, Cuñarro, Juan, Tovar, Sulay, Torres, Dolores, Alonso, María José, UCL - SSS/LDRI - Louvain Drug Research Institute, Santalices, Irene, Vázquez-Vázquez, Carlos, Santander-Ortega, Manuel J, Lozano, Victoria, Araújo, Francisca, Sarmento, Bruno, Shrestha, Neha, Préat, Véronique, Chenlo, Miguel, Alvarez, Clara V, Benetti, Federico, Cuñarro, Juan, Tovar, Sulay, Torres, Dolores, and Alonso, María José

Abstract

The potential of nanoemulsions for the oral administration of peptides is still in its early stage. The aim of the present work was to rationally design, develop, and fully characterize a new nanoemulsion (NE) intended for the oral administration of hydrophobically modified insulin (HM-insulin). Specific components of the NE were selected based on their enhancing permeation properties as well as their ability to improve insulin association efficiency (Miglyol 812, sodium taurocholate), stability in the intestinal fluids, and mucodiffusion (PEGylated phospholipids and poloxamer 407). The results showed that the NE co-existed with a population of micelles, forming a mixed system that exhibited a 100% of HM-insulin association efficiency. The nanosystem showed good stability and miscibility in different bio-relevant media and displayed an acceptable mucodiffusive behavior in porcine mucus. In addition, it exhibited a high interaction with cell mono-cultures (Caco -2 and C2BBe1 human colon carcinoma Caco-2 clone cells) and co-cultures (C2BBe1 human colon carcinoma Caco-2 clone/HT29-MTX cells). The internalization in Caco-2 monolayers was also confirmed by confocal microscopy. Finally, the promising in vitro behavior of the nanosystem in terms of overcoming the biological barriers of the intestinal tract was translated into a moderate, although significant, hypoglycemic response (≈ 20-30%), following intestinal administration to both healthy and diabetic rat models. Overall, this information underlines the crucial steps to address when designing peptide-based nanoformulations to successfully overcome the intestinal barriers associated to the oral modality of administration.

Published
2021

41. Correction to: A nanoemulsion/micelles mixed nanosystem for the oral administration of hydrophobically modified insulin.

Author

UCL - SSS/LDRI - Louvain Drug Research Institute, Santalices, Irene, Vázquez-Vázquez, Carlos, Santander-Ortega, Manuel J, Lozano, Victoria, Araújo, Francisca, Sarmento, Bruno, Shrestha, Neha, Préat, Véronique, Chenlo, Miguel, Alvarez, Clara V, Benetti, Federico, Cuñarro, Juan, Tovar, Sulay, Torres, Dolores, Alonso, María José, UCL - SSS/LDRI - Louvain Drug Research Institute, Santalices, Irene, Vázquez-Vázquez, Carlos, Santander-Ortega, Manuel J, Lozano, Victoria, Araújo, Francisca, Sarmento, Bruno, Shrestha, Neha, Préat, Véronique, Chenlo, Miguel, Alvarez, Clara V, Benetti, Federico, Cuñarro, Juan, Tovar, Sulay, Torres, Dolores, and Alonso, María José

Abstract

Correction to: Drug Delivery and Translational Research https://doi.org/10.1007/s13346-021-00920-x

Published
2021

50. Nuclear Cardiology

Author

Jiménez-Hoyuela García, José Manuel, primary, Lozano, Simeón Ortega, additional, Torres, Dolores Martínez del Valle, additional, Cardo, Antonio Guitiérrez, additional, and Moreno, Esperanza Ramos, additional

Published
2010
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