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1. Efficacy and safety of a structured de-escalation from antipseudomonal β-lactams in bloodstream infections due to Enterobacterales (SIMPLIFY): an open-label, multicentre, randomised trial

Author

De Cueto, Marina, Borreguero, Irene, Nieto Aranda, Javier, Sousa Domínguez, Adrián, González-Rico, Claudia, Fariñas, María Carmen, Fernández Ávila, María Luisa, Romero Palacios, Alberto, Guerrero Sánchez, Francisca María, Rúa Gómez, Marta, Bilbao del Olmo, Idoia, Calbo, Esther, Dietl, Beatriz, Ibarguren Pinilla, Maialen, Gómez-Ruiz de Arbulo, Marta, Torres Beceiro, Isabel, Machuca, Isabel, Cano, Ángela, Giner Oncina, Livia, Pinargote Celorio, Héctor, Cendejas, Emilio, Romero Gómez, María, Argüelles Curto, Adrián, Reguero, José María, Díaz-López, María Dolores, Paño, José Ramón, López-Cortés, Luis Eduardo, Delgado-Valverde, Mercedes, Moreno-Mellado, Elisa, Goikoetxea Aguirre, Josune, Guio Carrión, Laura, Blanco Vidal, María José, López Soria, Leyre Mónica, Pérez-Rodríguez, María Teresa, Martínez Lamas, Lucía, Arnaiz de las Revillas, Francisco, Armiñanzas, Carlos, Ruiz de Alegría-Puig, Carlos, Jiménez Aguilar, Patricia, del Carmen Martínez-Rubio, María, Sáez-Bejar, Carmen, de las Cuevas, Carmen, Martín-Aspas, Andrés, Galán, Fátima, Yuste, José Ramón, Leiva-León, José, Bou, Germán, Capón González, Patricia, Boix-Palop, Lucía, Xercavins-Valls, Mariona, Goenaga-Sánchez, Miguel Ángel, Anza, Diego Vicente, Castón, Juan José, Rufián, Manuel Recio, Merino, Esperanza, Rodríguez, Juan Carlos, Loeches, Belén, Cuervo, Guillermo, Guerra Laso, José Manuel, Plata, Antonio, Pérez Cortés, Salvador, López Mato, Pablo, Sierra Monzón, José Luis, Rosso-Fernández, Clara, Bravo-Ferrer, José María, Retamar-Gentil, Pilar, and Rodríguez-Baño, Jesús

Published
2024
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2. Dispersal history of SARS-CoV-2 in Galicia, Spain

Author

Gallego-García, Pilar, primary, Estévez-Gómez, Nuria, additional, De Chiara, Loretta, additional, Alvariño, Pilar, additional, Juiz-González, Pedro M., additional, Torres-Beceiro, Isabel, additional, Poza, Margarita, additional, Vallejo, Juan A., additional, Rumbo-Feal, Soraya, additional, Conde-Pérez, Kelly, additional, Aja-Macaya, Pablo, additional, Ladra, Susana, additional, Moreno-Flores, Antonio, additional, Gude-González, María J., additional, Coira, Amparo, additional, Aguilera, Antonio, additional, Costa-Alcalde, José J., additional, Trastoy, Rocío, additional, Barbeito-Castiñeiras, Gema, additional, García-Souto, Daniel, additional, Tubío, José M. C., additional, Trigo-Daporta, Matilde, additional, Camacho-Zamora, Pablo, additional, García Costa, Juan, additional, González-Domínguez, María, additional, Canoura-Fernández, Luis, additional, Glez-Peña, Daniel, additional, Pérez-Castro, Sonia, additional, Cabrera, Jorge J., additional, Daviña-Núñez, Carlos, additional, Godoy-Diz, Montserrat, additional, Treinta-Álvarez, Ana Belén, additional, Veiga, María Isabel, additional, Sousa, João Carlos, additional, Osório, Nuno S., additional, Comas, Iñaki, additional, González-Candelas, Fernando, additional, Hong, Samuel L., additional, Bollen, Nena, additional, Dellicour, Simon, additional, Baele, Guy, additional, Suchard, Marc A., additional, Lemey, Philippe, additional, Agulla, Andrés, additional, Bou, Germán, additional, Alonso-García, Pilar, additional, Pérez-del-Molino, María Luisa, additional, García-Campello, Marta, additional, Paz-Vidal, Isabel, additional, Regueiro, Benito, additional, and Posada, David, additional

Published
2024
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3. Dispersal history of SARS-CoV-2 in Galicia, Spain

Author

Banco Santander, Conferencia de Rectores de las Universidades Españolas, Consejo Superior de Investigaciones Científicas (España), Xunta de Galicia, European Commission, Research Foundation - Flanders, Wellcome Trust, National Institutes of Health (US), Foundation for Science and Technology, Gallego-García, Pilar, Estévez-Gómez, Nuria, De Chiara, Loretta, Alvariño, Pilar, Juiz-González, Pedro M., Torres-Beceiro, Isabel, Poza, Margarita, Vallejo, Juan A., Rumbo-Feal, Soraya, Conde-Pérez, Kelly, Aja-Macaya, Pablo, Ladra, Susana, Moreno-Flores, Antonio, Gude-González, María J., Coira, Amparo, Aguilera, Antonio, Costa-Alcalde, José J., Trastoy, Rocío, Barbeito-Castiñeiras, Gema, García-Souto, Daniel, Tubio, José M. C., Trigo-Daporta, Matilde, Camacho-Zamora, Pablo, García Costa, Juan, González-Domínguez, María, Luis Canoura-Fernández, Glez-Peña, Daniel, Pérez-Castro, Sonia, Cabrera, Jorge J., Daviña-Núñez, Carlos, Godoy-Diz, Montserrat, Treinta-Álvarez, Ana Belén, Veiga, Maria Isabel, Sousa, João Carlos, Osório, Nuno S., Comas, Iñaki, González-Candelas, Fernando, Hong, Samuel L., Bollen, Nena, Dellicour, Simon, Baele, Guy, Suchard, Marc A., Lemey, Philippe, Andrés Agulla, Bou, Germán, Alonso-García, Pilar, Pérez-del-Molino, María Luisa, García-Campello, Marta, Paz-Vidal, Isabel, Regueiro, Benito, Posada, David, Banco Santander, Conferencia de Rectores de las Universidades Españolas, Consejo Superior de Investigaciones Científicas (España), Xunta de Galicia, European Commission, Research Foundation - Flanders, Wellcome Trust, National Institutes of Health (US), Foundation for Science and Technology, Gallego-García, Pilar, Estévez-Gómez, Nuria, De Chiara, Loretta, Alvariño, Pilar, Juiz-González, Pedro M., Torres-Beceiro, Isabel, Poza, Margarita, Vallejo, Juan A., Rumbo-Feal, Soraya, Conde-Pérez, Kelly, Aja-Macaya, Pablo, Ladra, Susana, Moreno-Flores, Antonio, Gude-González, María J., Coira, Amparo, Aguilera, Antonio, Costa-Alcalde, José J., Trastoy, Rocío, Barbeito-Castiñeiras, Gema, García-Souto, Daniel, Tubio, José M. C., Trigo-Daporta, Matilde, Camacho-Zamora, Pablo, García Costa, Juan, González-Domínguez, María, Luis Canoura-Fernández, Glez-Peña, Daniel, Pérez-Castro, Sonia, Cabrera, Jorge J., Daviña-Núñez, Carlos, Godoy-Diz, Montserrat, Treinta-Álvarez, Ana Belén, Veiga, Maria Isabel, Sousa, João Carlos, Osório, Nuno S., Comas, Iñaki, González-Candelas, Fernando, Hong, Samuel L., Bollen, Nena, Dellicour, Simon, Baele, Guy, Suchard, Marc A., Lemey, Philippe, Andrés Agulla, Bou, Germán, Alonso-García, Pilar, Pérez-del-Molino, María Luisa, García-Campello, Marta, Paz-Vidal, Isabel, Regueiro, Benito, and Posada, David

Abstract

The dynamics of SARS-CoV-2 transmission are influenced by a variety of factors, including social restrictions and the emergence of distinct variants. In this study, we delve into the origins and dissemination of the Alpha, Delta, and Omicron variants of concern in Galicia, northwest Spain. For this, we leveraged genomic data collected by the EPICOVIGAL Consortium and from the GISAID database, along with mobility information from other Spanish regions and foreign countries. Our analysis indicates that initial introductions during the Alpha phase were predominantly from other Spanish regions and France. However, as the pandemic progressed, introductions from Portugal and the USA became increasingly significant. Notably, Galicia’s major coastal cities emerged as critical hubs for viral transmission, highlighting their role in sustaining and spreading the virus. This research emphasizes the critical role of regional connectivity in the spread of SARS-CoV-2 and offers essential insights for enhancing public health strategies and surveillance measures.

Published
2024

4. Efficacy and safety of a structured de-escalation from antipseudomonal β-lactams in bloodstream infections due to Enterobacterales (SIMPLIFY): an open-label, multicentre, randomised trial

Author

López-Cortés, Luis Eduardo, primary, Delgado-Valverde, Mercedes, additional, Moreno-Mellado, Elisa, additional, Goikoetxea Aguirre, Josune, additional, Guio Carrión, Laura, additional, Blanco Vidal, María José, additional, López Soria, Leyre Mónica, additional, Pérez-Rodríguez, María Teresa, additional, Martínez Lamas, Lucía, additional, Arnaiz de las Revillas, Francisco, additional, Armiñanzas, Carlos, additional, Ruiz de Alegría-Puig, Carlos, additional, Jiménez Aguilar, Patricia, additional, del Carmen Martínez-Rubio, María, additional, Sáez-Bejar, Carmen, additional, de las Cuevas, Carmen, additional, Martín-Aspas, Andrés, additional, Galán, Fátima, additional, Yuste, José Ramón, additional, Leiva-León, José, additional, Bou, Germán, additional, Capón González, Patricia, additional, Boix-Palop, Lucía, additional, Xercavins-Valls, Mariona, additional, Goenaga-Sánchez, Miguel Ángel, additional, Anza, Diego Vicente, additional, Castón, Juan José, additional, Rufián, Manuel Recio, additional, Merino, Esperanza, additional, Rodríguez, Juan Carlos, additional, Loeches, Belén, additional, Cuervo, Guillermo, additional, Guerra Laso, José Manuel, additional, Plata, Antonio, additional, Pérez Cortés, Salvador, additional, López Mato, Pablo, additional, Sierra Monzón, José Luis, additional, Rosso-Fernández, Clara, additional, Bravo-Ferrer, José María, additional, Retamar-Gentil, Pilar, additional, Rodríguez-Baño, Jesús, additional, De Cueto, Marina, additional, Borreguero, Irene, additional, Nieto Aranda, Javier, additional, Sousa Domínguez, Adrián, additional, González-Rico, Claudia, additional, Fariñas, María Carmen, additional, Fernández Ávila, María Luisa, additional, Romero Palacios, Alberto, additional, Guerrero Sánchez, Francisca María, additional, Rúa Gómez, Marta, additional, Bilbao del Olmo, Idoia, additional, Calbo, Esther, additional, Dietl, Beatriz, additional, Ibarguren Pinilla, Maialen, additional, Gómez-Ruiz de Arbulo, Marta, additional, Torres Beceiro, Isabel, additional, Machuca, Isabel, additional, Cano, Ángela, additional, Giner Oncina, Livia, additional, Pinargote Celorio, Héctor, additional, Cendejas, Emilio, additional, Romero Gómez, María, additional, Argüelles Curto, Adrián, additional, Reguero, José María, additional, Díaz-López, María Dolores, additional, and Paño, José Ramón, additional

Published
2024
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5. Dispersal history of SARS‐CoV‐2 in Galicia, Spain.

Author

Gallego‐García, Pilar, Estévez‐Gómez, Nuria, De Chiara, Loretta, Alvariño, Pilar, Juiz‐González, Pedro M., Torres‐Beceiro, Isabel, Poza, Margarita, Vallejo, Juan A., Rumbo‐Feal, Soraya, Conde‐Pérez, Kelly, Aja‐Macaya, Pablo, Ladra, Susana, Moreno‐Flores, Antonio, Gude‐González, María J., Coira, Amparo, Aguilera, Antonio, Costa‐Alcalde, José J., Trastoy, Rocío, Barbeito‐Castiñeiras, Gema, and García‐Souto, Daniel

Subjects
SARS-CoV-2, PUBLIC health surveillance
Abstract

The dynamics of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) transmission are influenced by a variety of factors, including social restrictions and the emergence of distinct variants. In this study, we delve into the origins and dissemination of the Alpha, Delta, and Omicron‐BA.1 variants of concern in Galicia, northwest Spain. For this, we leveraged genomic data collected by the EPICOVIGAL Consortium and from the GISAID database, along with mobility information from other Spanish regions and foreign countries. Our analysis indicates that initial introductions during the Alpha phase were predominantly from other Spanish regions and France. However, as the pandemic progressed, introductions from Portugal and the United States became increasingly significant. The number of detected introductions varied from 96 and 101 for Alpha and Delta to 39 for Omicron‐BA.1. Most of these introductions left a low number of descendants (<10), suggesting a limited impact on the evolution of the pandemic in Galicia. Notably, Galicia's major coastal cities emerged as critical hubs for viral transmission, highlighting their role in sustaining and spreading the virus. This research emphasizes the critical role of regional connectivity in the spread of SARS‐CoV‐2 and offers essential insights for enhancing public health strategies and surveillance measures. [ABSTRACT FROM AUTHOR]

Published
2024
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6. SARS-CoV-2 Evolution and Spike-Specific CD4+ T-Cell Response in Persistent COVID-19 with Severe HIV Immune Suppression

Author

Banco Santander, Consejo Superior de Investigaciones Científicas (España), Conferencia de Rectores de las Universidades Españolas, Xunta de Galicia, Álvarez, Hortensia [0000-0002-5002-1737], Ruiz-Mateos, Ezequiel [0000-0001-6747-7813], Vitallé, Joana [0000-0002-5292-1851], Vieitez, Irene [0000-0001-9241-0207], Pérez-Gómez, Alberto [0000-0002-3644-2914], Gallego-García, Pilar [0000-0001-8531-9851], Chiara , Loretta de [0000-0001-7700-6417], Poveda, Eva [0000-0003-4835-9875], Posada, David [0000-0003-1407-3406], Llibre, Josep María [0000-0002-7158-6753], Álvarez, Hortensia, Ruiz-Mateos, Ezequiel, Juiz-González, Pedro Miguel, Vitallé, Joana, Vieitez, Irene, Vázquez-Friol, María del Carmen, Torres-Beceiro, Isabel, Pérez-Gómez, Alberto, Gallego-García, Pilar, Estévez-Gómez, Nuria, Chiara , Loretta de, Poveda, Eva, Posada, David, Llibre, Josep María, Banco Santander, Consejo Superior de Investigaciones Científicas (España), Conferencia de Rectores de las Universidades Españolas, Xunta de Galicia, Álvarez, Hortensia [0000-0002-5002-1737], Ruiz-Mateos, Ezequiel [0000-0001-6747-7813], Vitallé, Joana [0000-0002-5292-1851], Vieitez, Irene [0000-0001-9241-0207], Pérez-Gómez, Alberto [0000-0002-3644-2914], Gallego-García, Pilar [0000-0001-8531-9851], Chiara , Loretta de [0000-0001-7700-6417], Poveda, Eva [0000-0003-4835-9875], Posada, David [0000-0003-1407-3406], Llibre, Josep María [0000-0002-7158-6753], Álvarez, Hortensia, Ruiz-Mateos, Ezequiel, Juiz-González, Pedro Miguel, Vitallé, Joana, Vieitez, Irene, Vázquez-Friol, María del Carmen, Torres-Beceiro, Isabel, Pérez-Gómez, Alberto, Gallego-García, Pilar, Estévez-Gómez, Nuria, Chiara , Loretta de, Poveda, Eva, Posada, David, and Llibre, Josep María

Abstract

Intra-host evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been reported in cases with persistent coronavirus disease 2019 (COVID-19). In this study, we describe a severely immunosuppressed individual with HIV-1/SARS-CoV-2 coinfection with a long-term course of SARS-CoV-2 infection. A 28-year-old man was diagnosed with HIV-1 infection (CD4+ count: 3 cells/µL nd 563000 HIV-1 RNA copies/mL) and simultaneous Pneumocystis jirovecii pneumonia, disseminated Mycobacterium avium complex infection and SARS-CoV-2 infection. SARS-CoV-2 real-time reverse transcription polymerase chain reaction positivity from nasopharyngeal samples was prolonged for 15 weeks. SARS-CoV-2 was identified as variant Alpha (PANGO lineage B.1.1.7) with mutation S:E484K. Spike-specific T-cell response was similar to HIV-negative controls although enriched in IL-2, and showed disproportionately increased immunological exhaustion marker levels. Despite persistent SARS-CoV-2 infection, adaptive intra-host SARS-CoV-2 evolution, was not identified. Spike-specific T-cell response protected against a severe COVID-19 outcome and the increased immunological exhaustion marker levels might have favoured SARS-CoV-2 persistence.

Published
2022

7. SARS-CoV-2 Evolution and Spike-Specific CD4+ T-Cell Response in Persistent COVID-19 with Severe HIV Immune Suppression

Author

Álvarez, Hortensia, primary, Ruiz-Mateos, Ezequiel, additional, Juiz-González, Pedro Miguel, additional, Vitallé, Joana, additional, Viéitez, Irene, additional, Vázquez-Friol, María del Carmen, additional, Torres-Beceiro, Isabel, additional, Pérez-Gómez, Alberto, additional, Gallego-García, Pilar, additional, Estévez-Gómez, Nuria, additional, De Chiara, Loretta, additional, Poveda, Eva, additional, Posada, David, additional, and Llibre, Josep M., additional

Published
2022
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8. Citomegalovirus en las Unidades de Quemados

Author

Ramírez Santillán, Cecilia, Torres Beceiro, Isabel, Cañizares Castellanos, Angelina, Ramírez Santillán, Cecilia, Torres Beceiro, Isabel, and Cañizares Castellanos, Angelina

Published
2016

9. Dispersal history of SARS-CoV-2 in Galicia, Spain.

Author

Gallego-García P, Estévez-Gómez N, De Chiara L, Alvariño P, Juiz-González PM, Torres-Beceiro I, Poza M, Vallejo JA, Rumbo-Feal S, Conde-Pérez K, Aja-Macaya P, Ladra S, Moreno-Flores A, Gude-González MJ, Coira A, Aguilera A, Costa-Alcalde JJ, Trastoy R, Barbeito-Castiñeiras G, García-Souto D, Tubio JMC, Trigo-Daporta M, Camacho-Zamora P, Costa JG, González-Domínguez M, Canoura-Fernández L, Glez-Peña D, Pérez-Castro S, Cabrera JJ, Daviña-Núñez C, Godoy-Diz M, Treinta-Álvarez AB, Veiga MI, Sousa JC, Osório NS, Comas I, González-Candelas F, Hong SL, Bollen N, Dellicour S, Baele G, Suchard MA, Lemey P, Agulla A, Bou G, Alonso-García P, Pérez-Del-Molino ML, García-Campello M, Paz-Vidal I, Regueiro B, and Posada D

Abstract

The dynamics of SARS-CoV-2 transmission are influenced by a variety of factors, including social restrictions and the emergence of distinct variants. In this study, we delve into the origins and dissemination of the Alpha, Delta, and Omicron variants of concern in Galicia, northwest Spain. For this, we leveraged genomic data collected by the EPICOVIGAL Consortium and from the GISAID database, along with mobility information from other Spanish regions and foreign countries. Our analysis indicates that initial introductions during the Alpha phase were predominantly from other Spanish regions and France. However, as the pandemic progressed, introductions from Portugal and the USA became increasingly significant. Notably, Galicia's major coastal cities emerged as critical hubs for viral transmission, highlighting their role in sustaining and spreading the virus. This research emphasizes the critical role of regional connectivity in the spread of SARS-CoV-2 and offers essential insights for enhancing public health strategies and surveillance measures., Competing Interests: Declaration of interest There are no conflicting interests.

Published
2024
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