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IntroductionAntiphospholipid syndrome (APS) is an autoimmune thrombotic disease with various systemic presentations. This study aimed to identify homogeneous groups of patients based on a non-supervised hierarchical cluster analysis and assess the rate of relapse associated with antinuclear antibodies (ANA).MethodsThis retrospective observational study enrolled patients, over a 90-month period, who had APS as defined by the 2006 Sydney classification criteria, and for whom ANA workup was performed. Agglomerative unsupervised hierarchical clustering was conducted to classify patients into subgroups using 24 variables reflecting a range of clinical and biological baseline features associated with APS.ResultsHundred and seventy-four patients were included and were categorized into four phenotypes. Cluster 1 (n=73) associated mostly middle-aged men with risk factors for cardiovascular disease. Obstetrical APS with low-risk thrombosis made up cluster 2 (n=25). Patients with venous thromboembolism (VTE), microvascular findings and double/triple positive APL antibodies (50%) were represented in cluster 3 (n=33). Whereas cluster 4 (n=43) characterized a predominantly female subpopulation with positive ANA and systemic lupus (n=23) that exhibited a high thrombotic risk and more frequent relapses (n=38) (p

This quantitative study explored criminal justice college students' satisfaction with the police. 176 college students in Suffolk County, Long Island and New York City participated in a survey. The study examined the extent to which satisfaction with the local police department differs by location (urban and suburban), gender (female and male), and race (Black, Latino, and White). The results suggested that students who were from suburban settings had higher levels of satisfaction with the police than students who were from urban settings. In terms of race, White students were significantly more satisfied than Black students. Regarding gender, females tended to have slightly lower satisfaction levels than males. The present findings can be used by urban and suburban police departments to gauge the levels of satisfaction and attitudes towards their institution by upcoming police officers and reflect on their own relations with their communities.

Introduction: G20210A (c.*97G>A) prothrombin gene variant, found in white population has been associated with an increased risk of venous thromboembolism (VTE). Other rare polymorphisms in F2 gene (C20209T) have been reported, more rare and touching black people, but its potential association with VTE remain uncertain. Methods: About a 69 years‐old Caucasian woman presenting an unprovoked deep venous thrombosis of the leg, we analyzed retrospectively 25.000 thrombophilia tests on a 11‐year period of time (2007–2018), at Nice and Marseille University Hospitals, and performed extensive review of the literature. Results: Genetic determination included a similar PCR protocol and sequencing. Twenty‐one heterozygous cases out of 25.585 determinations (0.08%) was found. The C20209T mutation detected in our Caucasian patient is rare, with a frequency that differed from what was reported in the previous literature, mainly in non‐Caucasian patients (Africans, Africans‐Americans, and Caribbeans). One hundred and thirteen patients with this mutation have been described in the literature, of which only one homozygous. Conclusion: This study is the most important on C20209T mutation performed at present, allowing to precise its frequency and its potential role in venous thromboembolism. [ABSTRACT FROM AUTHOR]

< p >Bisphenol A is a chemical substance that impairs estrogenic endocrine and the presence of BPA in water causes various problems for human health. The present study aims to evaluate the amount of BPA in bottled waters in Ardabil and to optimize the ozone condition for reducing it in water. For this purpose, 5 samples were selected out of 13 brands of bottled water. One sample of each brand was tested on the first day and 4 other samples were tested after 30 days of storage at temperatures of 5, 15, 25, and 40 °C using a high-performance liquid chromatography device. To determine the ozonation efficiency, at first, the concentration of consuming ozone, pH of the environment, duration of ozonation, and initial concentration of BPA were optimized and then tested under optimal conditions. On the first day, the amount of BPA in all brands was within the limits allowed by the Department of Health of America (20 µg/L). By increasing the temperature of storage, the amount of BPA increased in all samples and at 40 °C, its amount exceeded the allowable limit in 3 brands. Optimal conditions are achieved at an ozone concentration of 6 mg/l, pH equal to 7, concentration of dissolved BPA equal to 10 mg/l, and ozonation time in 10 minutes. Furthermore, ozonation in these conditions removed 90% of BPA in water. In general, it can be declared that the contamination of BPA in bottled waters increases during preservation, and especially at temperatures higher than a refrigerator (out of the refrigerator), and ozonation under optimized condition is an effective method to reduce it. < p > TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian // TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back // TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian // TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //

Background Recent literature reports a strong thrombotic tendency in patients hospitalized for a coronavirus disease 2019 (COVID‐19) infection. This characteristic is unusual and seems specific to COVID‐19 infections, especially in their severe form. Viral infections can trigger acquired thrombophilia, which can then lead to thrombotic complications. We investigate for the presence of acquired thrombophilia, which could participate in this phenomenon, and report its prevalence. We also wonder if these thrombophilias participate in the bad prognosis of severe COVID‐19 infections. Methods and Results In 89 consecutive patients hospitalized for COVID‐19 infection, we found a 20% prevalence of PS (protein S) deficiency and a high (ie, 72%) prevalence of antiphospholipid antibodies: mainly lupus anticoagulant. The presence of PS deficiency or antiphospholipid antibodies was not linked with a prolonged activated partial thromboplastin time nor with D‐dimer, fibrinogen, or CRP (C‐reactive protein) concentrations. These coagulation abnormalities are also not linked with thrombotic clinical events occurring during hospitalization nor with mortality. Conclusions We assess a high prevalence of positive tests detecting thrombophilia in COVID‐19 infections. However, in our series, these acquired thrombophilias are not correlated with the severity of the disease nor with the occurrence of thrombotic events. Albeit the strong thrombotic tendency in COVID‐19 infections, the presence of frequent acquired thrombophilia may be part of the inflammation storm of COVID‐19 and should not systematically modify our strategy on prophylactic anticoagulant treatment, which is already revised upwards in this pathological condition. Registration URL: https://www.clini​caltr​ials.gov; Unique identifier: NCT04335162.