151 results on '"Toyn, Jeremy H."'
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2. Synthesis of functionalized derivatives of the gamma-secretase modulator BMS-932481 and identification of its major metabolite
3. [ 3H]BMS-599240 — A novel tritiated ligand for the characterization of BACE1 inhibitors
4. Specialization of function among aldehyde dehydrogenases: the ALD2 and ALD3 genes are required for [beta]-alanine biosynthesis in Saccharomyces cerevisiae
5. A yeast genetic assay for caspase cleavage of the amyloid-β precursor protein
6. The selection and study of mutants of the yeast Saccharomyces cerevisiae that are defective for translocation of proteins into the endoplasmic reticulum
7. Soluble Aβ and cognitive function in aged F-344 rats and Tg2576 mice
8. The Swi5 transcription factor of Saccharomyces cerevisiae has a role in exit from mitosis through induction of the cdk-inhibitor Sic1 in telophase
9. The activation of DNA replication in yeast
10. Spo12 is a limiting factor that interacts with the cell cycle protein kinases Dbf2 and Dbf20, which are involved in mitotic chromatid disjunction
11. Dbf2/20
12. Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ-Secretase Modulator BMS-932481
13. Viable mouse gene ablations that robustly alter brain Aβ levels are rare
14. Discovery of furo[2,3-d][1,3]thiazinamines as beta amyloid cleaving enzyme-1 (BACE1) inhibitors
15. Synthesis of pyrimido[4,5-c]azepine- and pyrimido[4,5-c]oxepine-based γ-secretase modulators
16. Design and optimization of tricyclic gamma-secretase modulators
17. Macrocyclic prolinyl acyl guanidines as inhibitors of β-secretase (BACE)
18. Discovery of furo[2,3- d ][1,3]thiazinamines as beta amyloid cleaving enzyme-1 (BACE1) inhibitors
19. Discovery of S3-Truncated, C-6 Heteroaryl Substituted Aminothiazine β-Site APP Cleaving Enzyme-1 (BACE1) Inhibitors
20. Synthesis of pyrimido[4,5- c ]azepine- and pyrimido[4,5- c ]oxepine-based γ-secretase modulators
21. Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain Aβ Reduction in Rodents
22. Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors
23. Monosubstituted γ-lactam and conformationally constrained 1,3-diaminopropan-2-ol transition-state isostere inhibitors of β-secretase (BACE)
24. Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1
25. Discovery of S3-Truncated, C-6 Heteroaryl Substituted Aminothiazine β-Site APP Cleaving Enzyme-1 (BACE1) Inhibitors.
26. Interpreting Alzheimer’s disease clinical trials in light of the effects on amyloid-β
27. Identification and Preclinical Pharmacology of theγ-Secretase Modulator BMS-869780
28. Synthesis and SAR of hydroxyethylamine based phenylcarboxyamides as inhibitors of BACE
29. γ-Secretase Pharmacology: What Pharmacology Will Work for Alzheimer's Disease?
30. Pharmacodynamics of Selective Inhibition of γ-Secretase by Avagacestat
31. Acyl Guanidine Inhibitors of β-Secretase (BACE-1): Optimization of a Micromolar Hit to a Nanomolar Lead via Iterative Solid- and Solution-Phase Library Synthesis
32. Viable mouse gene ablations that robustly alter brain Aβ levels are rare
33. P3-288: Gamma-secretase inhibitors have intrinsically different potencies against Aβ production and Notch signaling
34. Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor
35. Application of quantitative LC–MS surrogate peptide methodology in the analysis of the amyloid beta peptide (Aβ) biosynthetic intermediate protein APP–βCTF
36. Amino-caprolactam derivatives as γ-secretase inhibitors
37. The Amyloid-β Rise and γ-Secretase Inhibitor Potency Depend on the Level of Substrate Expression
38. P-Glycoprotein Efflux and Other Factors Limit Brain Amyloid β Reduction by β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitors in Mice
39. Qualitative and quantitative characterization of the amyloid β peptide (Aβ) population in biological matrices using an immunoprecipitation–LC/MS assay
40. Signal Peptide Peptidase and γ-Secretase Share Equivalent Inhibitor Binding Pharmacology
41. P4-308: γ-secretase inhibitors differentially increase or decrease N-terminal variants of rat brain Aβ
42. Specialization of Function Among Aldehyde Dehydrogenases: The ALD2 and ALD3 Genes Are Required for β-Alanine Biosynthesis in Saccharomyces cerevisiae
43. Plasmid Construction by Linker-Assisted Homologous Recombination in Yeast
44. Saccharomyces cerevisiae Is Capable of de Novo Pantothenic Acid Biosynthesis Involving a Novel Pathway of β-Alanine Production from Spermine
45. A counterselection for the tryptophan pathway in yeast: 5-fluoroanthranilic acid resistance
46. A Yeast Genetic Assay for Caspase Cleavage of the Amyloid-beta Precursor Protein
47. Identification and Preclinical Pharmacology of the ɣ-Secretase Modulator BMS-869780.
48. A Bub2p-dependent spindle checkpoint pathway regulates the Dbf2p kinase in budding yeast
49. Swi5 Controls a Novel Wave of Cyclin Synthesis in Late Mitosis
50. DBF2 Protein Kinase Binds to and Acts through the Cell Cycle-Regulated MOB1 Protein
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