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12 results on '"Toyoda, Hiroko"'

4. Pre-post changes in psychosocial functioning among relatives of patients with depressive disorders after Brief Multifamily Psychoeducation: A pilot study

Author

Shiraishi Nao, Suzuki Masako, Toyoda Hiroko, Murase Yuka, Naito Atsuko, Sasaki Megumi, Konishi Mizuho, Takeuchi Hiroshi, Katsuki Fujika, Kubota Yosuke, Yoshimatsu Yoshiko, and Furukawa Toshiaki A

Subjects
Psychiatry, RC435-571
Abstract

Abstract Background Depressive disorder is often chronic and recurrent, and results in a heavy psychosocial burden on the families of patients with this disorder. This study aims to examine the effectiveness of brief multifamily psychoeducation designed to alleviate their psychosocial burden. Methods Thirty-two relatives of patients with major depressive disorder participated in an open study testing the effectiveness of brief multifamily psychoeducation. The intervention consisted of four sessions over the course of 6 weeks. Outcome measures focused on emotional distress, care burden and Expressed Emotion (EE). Results The emotional distress, care burden and EE of the family all showed statistically significant improvements from baseline to after the family intervention. The proportion of relatives scoring 9 or more on K6, which indicates possible depressive or anxiety disorder, decreased from sixteen relatives (50.0%) at baseline, to only 3 relatives (9.3%) after the intervention. Conclusions This study suggests that brief multifamily psychoeducation is a useful intervention to reduce the psychosocial burden of the relatives of patients with depressive disorder. Further evaluation of family psychoeducation for relatives of patients with depressive disorder is warranted.

Published
2011
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6. Pre-post changes in psychosocial functioning among relatives of patients with depressive disorders after Brief Multifamily Psychoeducation: A pilot study

Author

Katsuki, Fujika, primary, Takeuchi, Hiroshi, additional, Konishi, Mizuho, additional, Sasaki, Megumi, additional, Murase, Yuka, additional, Naito, Atsuko, additional, Toyoda, Hiroko, additional, Suzuki, Masako, additional, Shiraishi, Nao, additional, Kubota, Yosuke, additional, Yoshimatsu, Yoshiko, additional, and Furukawa, Toshiaki A, additional

Published
2011
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7. Discovery of Novel Benzimidazoles as Potent Inhibitors of TIE-2 and VEGFR-2 Tyrosine Kinase Receptors

Author

Hasegawa, Masaichi, primary, Nishigaki, Naohiko, additional, Washio, Yoshiaki, additional, Kano, Kazuya, additional, Harris, Philip A., additional, Sato, Hideyuki, additional, Mori, Ichiro, additional, West, Rob I., additional, Shibahara, Megumi, additional, Toyoda, Hiroko, additional, Wang, Liping, additional, Nolte, Robert T., additional, Veal, James M., additional, and Cheung, Mui, additional

Published
2007
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9. 1P231 Arrangement of myosin heads in intact and actin-extracted skinned myofibril bundles of striated muscle.(8. Muscle contraction and muscle protein,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)

Author

Takemori, Shigeru, primary, Kimura, Masako, additional, Yamaguchi, Maki, additional, Ohno, Tetsuo, additional, Okuyama, Hiroshi, additional, Toyoda, Hiroko, additional, Yagi, Naoto, additional, Tanishima, Yuichiro, additional, Yamada, Taku, additional, and Saitou, Keisuke, additional

Published
2006
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10. Anti-Apoptotic Effects of Recombinant Human Hepatocyte Growth Factor on Hepatocytes Were Associated with Intrahepatic Hemorrhage Suppression Indicated by the Preservation of Prothrombin Time.

Author

Motoi, Sotaro, Toyoda, Hiroko, Obara, Takashi, Ohta, Etsuko, Arita, Yoshihisa, Negishi, Kana, Moriya, Katsuhiro, Kuboi, Yoshikazu, Soejima, Motohiro, Imai, Toshio, Ido, Akio, Tsubouchi, Hirohito, and Kawano, Tetsu

Subjects
*HEPATOCYTE growth factor, *HEMORRHAGE, *LIVER failure, *LIVER cells, *PROTHROMBIN
Abstract

Hepatocyte growth factor (HGF) is an endogenously expressed bioactive substance that has a strong anti-apoptotic effect. In this study, we biochemically and histologically characterized the effects of rh-HGF on in vitro human hepatocyte injury and mouse acute liver failure (ALF) models, both of which were induced by antibody-mediated Fas signaling. rh-HGF inhibited intracellular caspase-3/7 activation and cytokeratin 18 (CK-18) fragment release in both models. Histologically, rh-HGF dramatically suppressed parenchymal damage and intrahepatic hemorrhage. Among the laboratory parameters, prothrombin time (PT) was strongly preserved by rh-HGF, and PT was well correlated with the degree of intrahepatic hemorrhage. These results showed that the anti-apoptotic effect of rh-HGF on hepatocytes coincided strikingly with the suppression of intrahepatic hemorrhage. PT was considered to be the best parameter that correlated with the intrahepatic hemorrhages associated with hepatocellular damage. The action of rh-HGF might derive not only from its anti-apoptosis effects on liver parenchymal cells but also from its stabilization of structural and vasculature integrity. [ABSTRACT FROM AUTHOR]

Published
2019
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11. Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi)

Author

YAMAMOTO, Kazuie, primary, MOGI, Yoshisuke, additional, WATANABE, Hiroyuki, additional, NINOMIYA, Eiji, additional, HORIO, Takatomo, additional, TOYODA, Hiroko, additional, YOSHIMOTO, Susumu, additional, MURATA, Thoru, additional, MASUDA, Shunsuke, additional, YAMAMOTO, Masatoshi, additional, HIRANO, Kozaburo, additional, MORI, Mitsukuni, additional, SUZUKI, Kenjiro, additional, MIYANAGA, Noriko, additional, OHASHI, Shohan, additional, DOBASHI, Tetsuo, additional, KOTANI, Tadao, additional, SUZUKI, Koitsu, additional, and SHIMADA, Tomoko, additional

Published
1979
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12. Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi)

Author

YAMATO, Kazuie, primary, MOGI, Yoshisuke, additional, WATANABE, Hiroyuki, additional, OUCHI, Ichizo, additional, HORIO, Takatomo, additional, TOYODA, Hiroko, additional, YOSHIMOTO, Susumu, additional, MURATA, Tohru, additional, MASUDA, Shunsuke, additional, YAMAMOTO, Masatoshi, additional, HIRANO, Kozaburo, additional, MORI, Mitsukuni, additional, SUZUKI, Kenjiro, additional, MIYANAGA, Noriko, additional, OHASHI, Shohan, additional, DOBASHI, Tetsuo, additional, KOTANI, Tadao, additional, and SHIMADA, Tomoko, additional

Published
1979
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