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3. Long-term outcomes of patients with primary intestinal follicular lymphoma managed with watch-and-wait strategy

Author

Iwamuro, Masaya, Tanaka, Takehiro, Ennishi, Daisuke, Matsueda, Kazuhiro, Yoshioka, Masao, Miyahara, Koji, Sakaguchi, Chihiro, Nishimura, Mamoru, Nagahara, Teruya, Mannami, Tomohiko, Takenaka, Ryuta, Oka, Shohei, Inoue, Masafumi, Takimoto, Hidetaka, Inaba, Tomoki, Kobayashi, Sayo, Toyokawa, Tatsuya, Tsugeno, Hirofumi, Suzuki, Seiyuu, Sawada, Sachiko, Tanaka, Shouichi, Tsuzuki, Takao, and Okada, Hiroyuki

Published
2023
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4. AJM300 (carotegrast methyl), an oral antagonist of α4-integrin, as induction therapy for patients with moderately active ulcerative colitis: a multicentre, randomised, double-blind, placebo-controlled, phase 3 study

Author

Motoya, Satoshi, Maemoto, Atsuo, Fujiya, Mikihiro, Ashida, Toshifumi, Goto, Mitsuru, Matsumoto, Takayuki, Suzuki, Yasuo, Hamahata, Yukihiro, Nakagawa, Tomoo, Kato, Naoya, Kato, Jun, Endo, Yutaka, Suzuki, Ryoichi, Matsuda, Koichiro, Ohmiya, Naoki, Katsushima, Shinji, Hosomi, Shuhei, Tarumi, Ken-ichi, Watanabe, Chiyuki, Saito, Mitsuru, Yokoyama, Yuichiro, Inaba, Tomoki, Sakata, Yasuhisa, Hongo, Hitoshi, Shibuya, Tomoyoshi, Kawakami, Kazuhiko, Kakuta, Yoichi, Irisawa, Atsushi, Yoshimura, Naoki, Fukuda, Katsuyuki, Shirai, Takayuki, Ichikawa, Hitoshi, Nagata, Junko, Suzuki, Takayoshi, Yokoyama, Kaoru, Tomidokoro, Takashi, Kojima, Yuichiro, Yamada, Masahiro, Yamamoto, Hideko, Yamamoto, Takayuki, Horiki, Noriyuki, Obata, Hirozumi, Inoue, Satoko, Tanaka, Shinji, Toyokawa, Tatsuya, Kunihiro, Masaki, Hisabe, Takashi, Ogata, Shinichi, Takeshima, Fuminao, Matsushima, Kayoko, Matsuhashi, Nobuyuki, Sakuraba, Hirotake, Iwabuchi, Masahiro, Tsuchiya, Akihiko, Uchiyama, Kan, Kanai, Takanori, Nakamura, Masanao, Yokoyama, Tadashi, Hida, Nobuyuki, Mitsuyama, Keiichi, Osada, Taro, Hiraoka, Sakiko, Tsuzuki, Tomoyuki, Masuo, Takashige, Hokari, Ryota, Kobayashi, Taku, Saruta, Masayuki, Araki, Masao, Araki, Hiroshi, Shimizu, Masahito, Kikuchi, Masakazu, Nishikawa, Takahiro, Takedatsu, Hidetoshi, Aoyagi, Kunihiko, Ochiai, Toshiaki, Toda, Nobuo, Mizokami, Yuji, Nagahori, Masakazu, Matsueda, Kazuhiro, Kino, Hitoshi, Kanamori, Akira, Suzuki, Tsunehiro, Sakurai, Toshiharu, Kudo, Masatoshi, Kitano, Atsuo, Hisamatsu, Tadakazu, Kumagai, Shinji, Ninomiya, Tomoyuki, Mori, Kenichiro, Yoshida, Shun-ichi, Goto, Mitsuhide, Matsuoka, Katsuyoshi, Watanabe, Mamoru, Ohmori, Toshihide, Nakajima, Koichi, Ishida, Tetsuya, Ishiguro, Yoh, Kanke, Kazunari, Kobayashi, Kiyonori, Hirai, Fumihito, Watanabe, Kenji, Mizusawa, Hidehiro, Kishida, Shuji, Miura, Yoshiharu, Ohta, Akira, Kajioka, Toshifumi, and Hibi, Toshifumi

Published
2022
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6. A study for every second day administration of vonoprazan for maintenance treatment of erosive GERD (ESD von GERD): a multicenter randomized cross-over study

Author

Matsuda, Soichiro, Kato, Mototsugu, Sakakibara, Yuko, Hamada, Hiroshige, Sasaki, Yoshihiro, Mori, Hideki, Hirai, Yuichiro, Inoue, Shuji, Toyokawa, Tatsuya, Kagaya, Takashi, Kuwai, Toshio, Esaka, Naoki, Yamashita, Haruhiro, Watanabe, Noriko, Matsumoto, Mio, Fujii, Hiroyuki, Demura, Mamiko, Kubo, Kimitoshi, Mabe, Katsuhiro, and Harada, Naohiko

Published
2022
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8. Beneficial Alterations of Intestinal Microbiota in Chronic Cholecystitis Patients Treated With NOTES Gallbladder‐Preserving Surgery.

Author

Deng, Lixin, Lv, Xinzhi, Wang, Taotao, Huang, Xishun, Huang, Qingrong, Li, Xianli, Wen, Chunhong, Chen, Li, Chen, Huidi, Zhang, Mingqing, and Toyokawa, Tatsuya

Subjects
FECAL analysis, RESEARCH funding, SHORT-chain fatty acids, GUT microbiome, BILE acids, CLINICAL trials, MINIMALLY invasive procedures, TREATMENT effectiveness, DNA, CHRONIC diseases, COMPARATIVE studies, CHOLECYSTITIS, SEQUENCE analysis
Abstract

Objective: NOTES gallbladder‐preserving surgery (N‐GPS) has been heralded as a new paradigm shift in minimally invasive surgery for chronic cholecystitis patients. The objective of this research was to evaluate the impact of N‐GPS on the intestinal microbiota of patients. Methods: The study selected patients with benign gallbladder disease (BG group) within 1 week preoperative (BG_DPR stage) and followed up over 1 year postoperative (BG_YPO stage) and selected healthy controls (HC group) whose sex, age, and BMI index matched with patients at BG_YPO stage, too. Accordingly, stool samples from healthy controls and two stages of patients with benign gallbladder disease were collected; among them, the selected samples were sent for 16S rDNA sequencing with Illumina MiSeq platform, and then, the combined samples were sent for short‐chain fatty acid (SCFA) analysis with GC‐MS platform. Results: The result of alpha diversity of Shannon index showed that the difference among the two stages of BG group and HC group wasn't statistically significant, while the result of beta diversity based on the weighted UniFrac distance suggested that the structure of intestinal microbiota of BG group at YPO stage was closer to HC group. LEfSe analysis suggested that BG_YPO stage enriched genus, such as Enterocloster and Hungatella_A_128155, which improved bile acid metabolism. Compared with BG_DPR stage, BG_YPO stage and HC group enriched Faecalibacterium and Roseburia, but depleted Streptococcus, while fecal SCFA concentrations increased. Conclusion: Patients with benign gallbladder disease and chronic cholecystitis after N‐GPS treatment for over 1 year improved gut microbial community structure. With the improving bile acid metabolism, SCFA‐producing bacteria increased and pathobionts decreased, which helped the intestinal microbiota structure of BG group at YPO stage restore and close to HC group. Trial Registration: Chinese Clinical Trial Registry identifier: ChiCTR1900028267. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Results of the interim analysis of a prospective, multicenter, observational study of small subepithelial lesions in the stomach.

Author

Iwamuro, Masaya, Mitsuhashi, Toshiharu, Inaba, Tomoki, Matsueda, Kazuhiro, Nagahara, Teruya, Takeuchi, Yoji, Doyama, Hisashi, Mizuno, Masakatsu, Yada, Tomoyuki, Kawai, Yoshinari, Nakamura, Jun, Matsubara, Minoru, Nebiki, Hiroko, Niimi, Keiko, Toyokawa, Tatsuya, Takenaka, Ryuta, Takeda, Sho, Tanaka, Shouichi, Nishimura, Mamoru, and Tsuzuki, Takao

Subjects
SCIENTIFIC observation, STOMACH, NATURAL history, TUMOR surgery, GASTROINTESTINAL stromal tumors
Abstract

Objectives: Long‐term outcomes of gastric subepithelial lesions have not been elucidated. To reveal the natural history, we initiated a prospective, 10‐year follow‐up of patients with small (≤20 mm) gastric subepithelial lesions in September 2014. Here, we report the results of an interim analysis of a prospective observational study. Methods: In total, 567 patients with 610 lesions were prospectively registered between September 2014 and August 2016. The location, size, morphology, and number of subepithelial lesions were recorded on a web‐based case report form. This study has been conducted as an Academic Committee Working Group of the Japan Gastroenterological Endoscopy Society. Results: The endoscopic follow‐up period was 4.60 ± 1.73 years (mean ± standard deviation), and survival data were investigated for 5.28 ± 1.68 years. This interim analysis revealed that the estimated cumulative incidence of a size increase ≥5 mm, after accounting for patients' death and resection of the tumor as competing risk events, was 4.5% at 5 years. In addition, the estimated cumulative incidence of lesion size increase ≥5 mm or resection of lesions was 7.9% at 5 years, and that of size increase ≥10 mm or resection of lesions was 4.5% at 5 years. Conclusion: These results indicate that approximately one in 13 patients with small (≤20 mm) gastric subepithelial lesions may require resection or further investigation for increased tumor size (≥5 mm) within 5 years. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Endoscopic and clinical features of gastric emphysema

Author

Iwamuro, Masaya, primary, Takenaka, Ryuta, additional, Toyokawa, Tatsuya, additional, Kita, Masahide, additional, Tsuzuki, Takao, additional, Yoshioka, Masao, additional, Gotoda, Tatsuhiro, additional, Okanoue, Shotaro, additional, Matsubara, Minoru, additional, Sakaguchi, Chihiro, additional, and Otsuka, Motoyuki, additional

Published
2023
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13. Lesion size, elevated morphology, and non or closed-type atrophy are predictive factors for gastric adenocarcinoma of the fundic gland type rather than oxyntic gland adenoma

Author

Iwamuro, Masaya, Kusumoto, Chiaki, Nakagawa, Masahiro, Matsueda, Kazuhiro, Kobayashi, Sayo, Yoshioka, Masao, Inaba, Tomoki, Toyokawa, Tatsuya, Sakaguchi, Chihiro, Tanaka, Shouichi, Tanaka, Takehiro, and Okada, Hiroyuki

Subjects
oxyntic gland adenoma, Gastric adenocarcinoma of the fundic gland type (GA-FG), Oncology, gastric neoplasms, submucosal invasion, Gastroenterology
Abstract

Background: An oxyntic gland neoplasm confined to the mucosal layer (T1a) is classified as an oxyntic gland adenoma, whereas that with submucosal invasion (T1b) is defined as gastric adenocarcinoma of the fundic gland type (GA-FG). Methods: To reveal the differences in clinical features between them, we retrospectively investigated 136 patients with 150 oxyntic gland adenoma and GA-FG lesions. Results: The univariate analysis revealed that the mean size (GA-FG vs. oxyntic gland adenoma, 7.7±5.4 vs. 5.5±3.1 mm), the prevalence of elevated morphology (79.1% vs. 51.8%), black pigmentation within the lesion (23.9% vs. 9.6%), and non or closed-type atrophy (81.2% vs. 65.1%) were different between the two groups. A multivariate logistic regression analysis revealed that ≥5 mm lesion size (odds ratio, 2.96; 95% confidence interval: 1.21–7.23), elevated morphology (odds ratio, 2.40; 95% confidence interval: 1.06–5.45), and no or closed-type atrophy (odds ratio, 2.49; 95% confidence interval: 1.07–5.80) were factors in distinguishing GA-FG from oxyntic gland adenoma. When oxyntic gland neoplasms with no or one feature were judged as oxyntic gland adenomas and those with two or three features were judged as GA-FG, the sensitivity and specificity were 85.1% and 43.4% for GA-FG, respectively. Conclusions: We identified three possible distinctive features of GA-FG compared to oxyntic gland adenoma: lesion size ≥5 mm, elevated morphology, and no or closed-type atrophy.

Published
2023
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15. Current prognostic factors of advanced gastric cancer patients treated with chemotherapy: real world data from a Japanese 12 institutions

Author

Yamamoto, Shumpei, primary, Kanzaki, Hiromitsu, additional, Sakaguchi, Chihiro, additional, Mouri, Hirokazu, additional, Tsuzuki, Takao, additional, Nasu, Junichiro, additional, Kobayashi, Sayo, additional, Toyokawa, Tatsuya, additional, Obayashi, Yuka, additional, Inoue, Masafumi, additional, Kato, Ryo, additional, Matsubara, Minoru, additional, Kita, Masahide, additional, and Okada, Hiroyuki, additional

Published
2023
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16. Results of the interim analysis of a prospective, multicenter, observational study of small subepithelial lesions in the stomach

Author

Iwamuro, Masaya, primary, Mitsuhashi, Toshiharu, additional, Inaba, Tomoki, additional, Matsueda, Kazuhiro, additional, Nagahara, Teruya, additional, Takeuchi, Yoji, additional, Doyama, Hisashi, additional, Mizuno, Masakatsu, additional, Yada, Tomoyuki, additional, Kawai, Yoshinari, additional, Nakamura, Jun, additional, Matsubara, Minoru, additional, Nebiki, Hiroko, additional, Niimi, Keiko, additional, Toyokawa, Tatsuya, additional, Takenaka, Ryuta, additional, Takeda, Sho, additional, Tanaka, Shouichi, additional, Nishimura, Mamoru, additional, Tsuzuki, Takao, additional, Akahoshi, Kazuya, additional, Furuta, Takahisa, additional, Haruma, Ken, additional, and Okada, Hiroyuki, additional

Published
2023
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17. Clinicopathological Characteristics of Superficial Barrett's Adenocarcinoma in a Japanese Population: A Retrospective, Multicenter Study

Author

Hamada, Kenta, Kanzaki, Hiromitsu, Miyahara, Koji, Nakagawa, Masahiro, Mouri, Hirokazu, Mizuno, Motowo, Takahashi, Sakuma, Hori, Shinichiro, Nasu, Junichiro, Tsuzuki, Takao, Miyaike, Jiro, Takenaka, Ryuta, Yamauchi, Kenji, Kobayashi, Sayo, Toyokawa, Tatsuya, Inoue, Masafumi, Nishimura, Mamoru, Matsubara, Minoru, Tomoda, Jun, Yamasaki, Yasushi, Tanaka, Takehiro, Shirakawa, Yasuhiro, Kawahara, Yoshiro, Fujiwara, Toshiyoshi, Okada, Hiroyuki, and Okayama Gut Study Group

Subjects
Barrett's adenocarcinoma, lesion, surgery, Barrett Esophagus, endoscopic resection, Esophageal Neoplasms, Japan, short -segment Barrett's esophagus, metachronous, Humans, Adenocarcinoma, Retrospective Studies, long -segment Barrett's esophagus
Abstract

Objective Although Barrett's adenocarcinoma (BA) remains a minor disease in Japan, its incidence has been gradually increasing. We analyzed the characteristics of BA in Japanese populations. Methods We retrospectively reviewed medical records and analyzed the clinicopathological differences between short-segment Barrett's esophagus (SSBE) and long-segment Barrett's esophagus (LSBE), as well as metastasis. Local recurrence and metachronous lesions were analyzed only in patients who underwent endoscopic resection (ER). Patients Consecutive patients who had pathological T1 BAs resected by ER or surgery from January 2003 Results A total of 168 patients were analyzed, including 139 with SSBE and 29 with LSBE. In total, 67% of the SSBE lesions and 32% of the LSBE lesions were located between 0 and 3 o'clock (p=0.0014). No patients who achieved pathological margin-free resection (pR0) and 17% of patients who did not achieve pR0 experienced local recurrence (p=0.0131). None of the patients without lymphovascular involvement, a poorly differentiated component, lesion size of >30 mm, and submucosal invasion of >500 mu m experienced metastasis. The 5-year cumulative incidence rate of metachronous BA after ER was 0% in patients with SSBE and 40% in patients with LSBE (p=0.0005). Conclusion Superficial BA was likely to be detected at the right anterior wall of SSBE in the Japanese population. The risk for metachronous BA after ER was high in Japanese patients with LSBE, as in Western patients.

Published
2022

18. Multicenter Prospective Study on the Safety of Upper Gastrointestinal Endoscopic Procedures in Antithrombotic Drug Users

Author

Kono, Yoshiyasu, Matsubara, Minoru, Toyokawa, Tatsuya, Takenaka, Ryuta, Suzuki, Seiyu, Nasu, Junichirou, Yoshioka, Masao, Nakagawa, Masahiro, Mizuno, Motowo, Sakae, Hiroyuki, Abe, Makoto, Gotoda, Tatsuhiro, Miura, Ko, Kanzaki, Hiromitsu, Iwamuro, Masaya, Hori, Keisuke, Tsuzuki, Takao, Kita, Masahide, Kawano, Seiji, Kawahara, Yoshiro, and Okada, Hiroyuki

Published
2017
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19. AJM300 (carotegrast methyl), an oral antagonist of α4-integrin, as induction therapy for patients with moderately active ulcerative colitis: a multicentre, randomised, double-blind, placebo-controlled, phase 3 study

Author

Matsuoka, Katsuyoshi, primary, Watanabe, Mamoru, additional, Ohmori, Toshihide, additional, Nakajima, Koichi, additional, Ishida, Tetsuya, additional, Ishiguro, Yoh, additional, Kanke, Kazunari, additional, Kobayashi, Kiyonori, additional, Hirai, Fumihito, additional, Watanabe, Kenji, additional, Mizusawa, Hidehiro, additional, Kishida, Shuji, additional, Miura, Yoshiharu, additional, Ohta, Akira, additional, Kajioka, Toshifumi, additional, Hibi, Toshifumi, additional, Motoya, Satoshi, additional, Maemoto, Atsuo, additional, Fujiya, Mikihiro, additional, Ashida, Toshifumi, additional, Goto, Mitsuru, additional, Matsumoto, Takayuki, additional, Suzuki, Yasuo, additional, Hamahata, Yukihiro, additional, Nakagawa, Tomoo, additional, Kato, Naoya, additional, Kato, Jun, additional, Endo, Yutaka, additional, Suzuki, Ryoichi, additional, Matsuda, Koichiro, additional, Ohmiya, Naoki, additional, Katsushima, Shinji, additional, Hosomi, Shuhei, additional, Tarumi, Ken-ichi, additional, Watanabe, Chiyuki, additional, Saito, Mitsuru, additional, Yokoyama, Yuichiro, additional, Inaba, Tomoki, additional, Sakata, Yasuhisa, additional, Hongo, Hitoshi, additional, Shibuya, Tomoyoshi, additional, Kawakami, Kazuhiko, additional, Kakuta, Yoichi, additional, Irisawa, Atsushi, additional, Yoshimura, Naoki, additional, Fukuda, Katsuyuki, additional, Shirai, Takayuki, additional, Ichikawa, Hitoshi, additional, Nagata, Junko, additional, Suzuki, Takayoshi, additional, Yokoyama, Kaoru, additional, Tomidokoro, Takashi, additional, Kojima, Yuichiro, additional, Yamada, Masahiro, additional, Yamamoto, Hideko, additional, Yamamoto, Takayuki, additional, Horiki, Noriyuki, additional, Obata, Hirozumi, additional, Inoue, Satoko, additional, Tanaka, Shinji, additional, Toyokawa, Tatsuya, additional, Kunihiro, Masaki, additional, Hisabe, Takashi, additional, Ogata, Shinichi, additional, Takeshima, Fuminao, additional, Matsushima, Kayoko, additional, Matsuhashi, Nobuyuki, additional, Sakuraba, Hirotake, additional, Iwabuchi, Masahiro, additional, Tsuchiya, Akihiko, additional, Uchiyama, Kan, additional, Kanai, Takanori, additional, Nakamura, Masanao, additional, Yokoyama, Tadashi, additional, Hida, Nobuyuki, additional, Mitsuyama, Keiichi, additional, Osada, Taro, additional, Hiraoka, Sakiko, additional, Tsuzuki, Tomoyuki, additional, Masuo, Takashige, additional, Hokari, Ryota, additional, Kobayashi, Taku, additional, Saruta, Masayuki, additional, Araki, Masao, additional, Araki, Hiroshi, additional, Shimizu, Masahito, additional, Kikuchi, Masakazu, additional, Nishikawa, Takahiro, additional, Takedatsu, Hidetoshi, additional, Aoyagi, Kunihiko, additional, Ochiai, Toshiaki, additional, Toda, Nobuo, additional, Mizokami, Yuji, additional, Nagahori, Masakazu, additional, Matsueda, Kazuhiro, additional, Kino, Hitoshi, additional, Kanamori, Akira, additional, Suzuki, Tsunehiro, additional, Sakurai, Toshiharu, additional, Kudo, Masatoshi, additional, Kitano, Atsuo, additional, Hisamatsu, Tadakazu, additional, Kumagai, Shinji, additional, Ninomiya, Tomoyuki, additional, Mori, Kenichiro, additional, Yoshida, Shun-ichi, additional, and Goto, Mitsuhide, additional

Published
2022
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20. Additional file 1 of Endoscopic features of oxyntic gland adenoma and gastric adenocarcinoma of the fundic gland type differ between patients with and without Helicobacter pylori infection: a retrospective observational study

Author

Iwamuro, Masaya, Kusumoto, Chiaki, Nakagawa, Masahiro, Matsueda, Kazuhiro, Kobayashi, Sayo, Yoshioka, Masao, Inaba, Tomoki, Toyokawa, Tatsuya, Sakaguchi, Chihiro, Tanaka, Shouichi, Tanaka, Takehiro, and Okada, Hiroyuki

Abstract

Additional file 1. Table S1. Comparison of the active and inactive gastritis groups.

Published
2022
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21. SIGNIFICANCE OF EUS IN THE FOLLOW-UP OF SMALL SUBEPITHELIAL LESIONS IN THE STOMACH: A PROSPECTIVE, MULTICENTER, OBSERVATIONAL STUDY.

Author

Nebiki, Hiroko, Iwamuro, Masaya, Inaba, Tomoki, Matsueda, Kazuhiro, Takeuchi, Yoji, Nagahara, Teruya, Doyama, Hisashi, Mizuno, Masakatsu, Yada, Tomoyuki, Kawai, Yoshinari, Nakamura, Jun, Matubara, Minoru, Toyokawa, Tatsuya, Takenaka, Ryuta, Takeda, Sho, Tanaka, Shouichi, Nishimura, Mamoru, Tsuzuki, Takao, Akahoshi, Kazuya, and Fujishiro, Mitsuhiro

Published
2024
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22. Endoscopic Features of Oxyntic Gland Adenoma and Gastric Adenocarcinoma of the Fundic Gland Type Differ Between Patients with and Without Helicobacter pylori Infection: A Retrospective Observational Study

Author

Iwamuro, Masaya, primary, Kusumoto, Chiaki, additional, Nakagawa, Masahiro, additional, Matsueda, Kazuhiro, additional, Kobayashi, Sayo, additional, Yoshioka, Masao, additional, Inaba, Tomoki, additional, Toyokawa, Tatsuya, additional, Sakaguchi, Chihiro, additional, Tanaka, Shouichi, additional, Tanaka, Takehiro, additional, and Okada, Hiroyuki, additional

Published
2022
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24. Erratum to: Multicenter Prospective Study on the Safety of Upper Gastrointestinal Endoscopic Procedures in Antithrombotic Drug Users

Author

Kono, Yoshiyasu, Matsubara, Minoru, Toyokawa, Tatsuya, Takenaka, Ryuta, Suzuki, Seiyu, Nasu, Junichirou, Yoshioka, Masao, Nakagawa, Masahiro, Mizuno, Motowo, Sakae, Hiroyuki, Abe, Makoto, Gotoda, Tatsuhiro, Miura, Ko, Kanzaki, Hiromitsu, Iwamuro, Masaya, Hori, Keisuke, Tsuzuki, Takao, Kita, Masahide, Kawano, Seiji, Kawahara, Yoshiro, and Okada, Hiroyuki

Published
2017
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25. A multicenter survey of enteroscopy for the diagnosis of intestinal follicular lymphoma

Author

IWAMURO, MASAYA, OKADA, HIROYUKI, KAWANO, SEIJI, SHIODE, JUNJI, TAKENAKA, RYUTA, IMAGAWA, ATSUSHI, INABA, TOMOKI, SUZUKI, SEIYU, NISHIMURA, MAMORU, MIZUNO, MOTOWO, ARAKI, MASASHI, MANNAMI, TOMOHIKO, UEKI, TORU, KOBASHI, HARUHIKO, FUKATSU, HARUKA, TANAKA, SHOUICHI, OMOTO, AKIYOSHI, KAWAI, YOSHINARI, KITAGAWA, TAKASHI, TOYOKAWA, TATSUYA, TAKATA, KATSUYOSHI, YOSHINO, TADASHI, TAKAKI, AKINOBU, and YAMAMOTO, KAZUHIDE

Published
2015
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26. A prospective multicenter study of the magnifying endoscopic evaluation of the invasion depth of superficial esophageal cancers

Author

Gotoda, Tatsuhiro, primary, Hori, Keisuke, additional, Nakagawa, Masahiro, additional, Kobayashi, Sayo, additional, Toyokawa, Tatsuya, additional, Ishiyama, Shuhei, additional, Imagawa, Atsushi, additional, Abe, Makoto, additional, Kono, Yoshiyasu, additional, Kanzaki, Hiromitsu, additional, Iwamuro, Masaya, additional, Kawano, Seiji, additional, Kawahara, Yoshiro, additional, and Okada, Hiroyuki, additional

Published
2021
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27. Efficacy and safety of endoscopic submucosal dissection for gastric tube cancer: A multicenter retrospective study

Author

Satomi, Takuya, Kawano, Seiji, Inaba, Tomoki, Nakagawa, Masahiro, Mouri, Hirokazu, Yoshioka, Masao, Tanaka, Shoichi, Toyokawa, Tatsuya, Kobayashi, Sayo, Tanaka, Takehiro, Kanzaki, Hiromitsu, Iwamuro, Masaya, Kawahara, Yoshiro, Okada, Hiroyuki, Satomi, Takuya, Kawano, Seiji, Inaba, Tomoki, Nakagawa, Masahiro, Mouri, Hirokazu, Yoshioka, Masao, Tanaka, Shoichi, Toyokawa, Tatsuya, Kobayashi, Sayo, Tanaka, Takehiro, Kanzaki, Hiromitsu, Iwamuro, Masaya, Kawahara, Yoshiro, and Okada, Hiroyuki

Abstract

BACKGROUND Recent improvements in the prognosis of patients with esophageal cancer have led to the increased occurrence of gastric tube cancer (GTC) in the reconstructed gastric tube. However, there are few reports on the treatment results of endoscopic submucosal dissection (ESD) for GTC. AIM To evaluate the efficacy and safety of ESD for GTC after esophagectomy in a multicenter trial. METHODS We retrospectively investigated 48 GTC lesions in 38 consecutive patients with GTC in the reconstructed gastric tube after esophagectomy who had undergone ESD between January 2005 and December 2019 at 8 institutions participating in the Okayama Gut Study group. The clinical indications of ESD for early gastric cancer were similarly applied for GTC after esophagectomy. ESD specimens were evaluated in 2-mm slices according to the Japanese Classification of Gastric Carcinoma with curability assessments divided into curative and non-curative resection based on the Gastric Cancer Treatment Guidelines. Patient characteristics, treatment results, clinical course, and treatment outcomes were analyzed. RESULTS The median age of patients was 71.5 years (range, 57-84years), and there were 34 men and 4 women. The median observation period after ESD was 884 d (range, 8-4040 d). The median procedure time was 81 min (range, 29-334 min), the en bloc resection rate was 91.7% (44/48), and the curative resection rate was 79% (38/48). Complications during ESD were seen in 4% (2/48) of case, and those after ESD were seen in 10% (5/48) of case. The survival rate at 5 years was 59.5%. During the observation period after ESD, 10 patients died of other diseases. Although there were differences in the procedure time between institutions, a multivariate analysis showed that tumor size was the only factor associated with prolonged procedure time. CONCLUSION ESD for GTC after esophagectomy was shown to be safe and effective.

Published
2021

31. Efficacy and safety of endoscopic submucosal dissection for gastric tube cancer: A multicenter retrospective study

Author

Satomi, Takuya, primary, Kawano, Seiji, additional, Inaba, Tomoki, additional, Nakagawa, Masahiro, additional, Mouri, Hirokazu, additional, Yoshioka, Masao, additional, Tanaka, Shoichi, additional, Toyokawa, Tatsuya, additional, Kobayashi, Sayo, additional, Tanaka, Takehiro, additional, Kanzaki, Hiromitsu, additional, Iwamuro, Masaya, additional, Kawahara, Yoshiro, additional, and Okada, Hiroyuki, additional

Published
2021
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32. Continued Aspirin Treatment May Be a Risk Factor of Delayed Bleeding after Gastric Endoscopic Submucosal Dissection under Heparin Replacement: A Retrospective Multicenter Study

Author

Hamada, Kenta, Kanzaki, Hiromitsu, Inoue, Masafumi, Ishiyama , Shuhei, Yamauchi, Kenji, Miyahara, Koji, Toyokawa, Tatsuya, Tsuzuki, Takao, Miyaike, Jiro, Matsubara, Minoru, Takahashi, Sakuma, Nishimura, Mamoru, Takenaka, Ryuta, Yunoki, Naoko, Hori, Shinichiro, Kobayashi, Sayo, Yamasaki, Yasushi, Kawahara, Yoshiro, Ishikawa, Hideki, Okada, Hiroyuki, Hamada, Kenta, Kanzaki, Hiromitsu, Inoue, Masafumi, Ishiyama , Shuhei, Yamauchi, Kenji, Miyahara, Koji, Toyokawa, Tatsuya, Tsuzuki, Takao, Miyaike, Jiro, Matsubara, Minoru, Takahashi, Sakuma, Nishimura, Mamoru, Takenaka, Ryuta, Yunoki, Naoko, Hori, Shinichiro, Kobayashi, Sayo, Yamasaki, Yasushi, Kawahara, Yoshiro, Ishikawa, Hideki, and Okada, Hiroyuki

Abstract

Objective Gastric endoscopic submucosal dissection (ESD) under heparin replacement (HR) of warfarin reportedly has a high risk of delayed bleeding (24-57%). It is possible that the delayed bleeding risk may have changed over the years. We evaluated the current risk of delayed bleeding after gastric ESD under HR of anticoagulant agents. Methods We retrospectively reviewed the delayed bleeding rate and analyzed the risk factors for delayed bleeding. Patients Consecutive patients who underwent gastric ESD under HR of anticoagulant agents from July 2015 to June 2017. Results A total of 32 patients with a solitary early gastric cancer and taking anticoagulant agents were analyzed, including 24 patients on warfarin (the warfarin group) and 8 patients on direct oral anticoagulants (the DOAC group). Three (9.4%) patients experienced delayed bleeding: three (12.5%) patients in the warfarin group and no patients in the DOAC group. Continued aspirin treatment was identified to be a risk factor of delayed bleeding (p=0.01). Conclusion Careful management may be required for patients undergoing gastric ESD under continued aspirin treatment in addition to HR of anticoagulant agents; although the delayed bleeding risk after gastric ESD under HR of anticoagulant agents might have decreased over the years.

Published
2020

34. Helicobacter pylori heat-shock protein 60 induces inflammatory responses through the Toll-like receptor-triggered pathway in cultured human gastric epithelial cells

Author

Takenaka, Ryuta, Yokota, Kenji, Ayada, Kiyoshi, Mizuno, Motowo, Zhao, Ying, Fujinami, Yoshihito, Lin, Song-Nan, Toyokawa, Tatsuya, Okada, Hiroyuki, Shiratori, Yasushi, and Oguma, Keiji

Subjects
Heat shock proteins -- Research, Helicobacter pylori -- Research, Biological sciences
Abstract

Contact between Helicobacter pylori and gastric epithelial cells results in activation of NF-[kappa]B followed by secretion of interleukin (IL)-8. However, host-cell receptor(s) and their ligands involved in H. pylori-related IL-8 production have yet to be fully defined. In this study, the interaction between Toll-like receptors (TLRs), which are host receptors for pathogens involved in the innate immune response, and heat-shock protein (HSP) 60, an immune-potent antigen of H. pylori, was examined during H. pylori-induced IL-8 secretion in vitro. Recombinant H. pylori HSP60 (rHpHSP60) was prepared and added to cultured KATO III human gastric epithelial cells with or without pre-incubation with mouse monoclonal anti-TLR2 or anti-TLR4 antibodies. IL-8 mRNA expression and IL-8 protein release were analysed by Northern blotting and immunoassay. Involvement of NF-[kappa]B activation was analysed immunocytochemically by anti-NF-[kappa]B p65 antibody and ammonium pyrrolidinedithiocarbamate (PDTC), an inhibitor of NF-[kappa]B-mediated transcriptional activation, rHpHSP60 induced IL-8 mRNA expression and IL-8 secretion in a dose-dependent manner in KATO III cells. Anti-TLR2 antibody inhibited rHpHSP60-induced IL-8 secretion by 75%, and anti-TLR4 antibody inhibited it by 30%. rHpHSP60 induced nuclear translocation of NF-[kappa]B p65, which was inhibited by pretreatment with anti-TLR2 antibody. Treatment with PDTC significantly decreased the secretion of IL-8 induced by rHpHSP60. These findings suggest that H. pylori HSP60 activates NF-[kappa]B and induces IL-8 production through TLR-triggered pathways in gastric epithelial cells. Thus, it is possible that H. pylori HSP60 and TLR interaction in host cells contributes to the development of gastric inflammation caused by H. pylori infection.

Published
2004

38. Continued Aspirin Treatment May Be a Risk Factor of Delayed Bleeding after Gastric Endoscopic Submucosal Dissection under Heparin Replacement: A Retrospective Multicenter Study

Author

Hamada, Kenta, primary, Kanzaki, Hiromitsu, additional, Inoue, Masafumi, additional, Ishiyama, Shuhei, additional, Yamauchi, Kenji, additional, Miyahara, Koji, additional, Toyokawa, Tatsuya, additional, Tsuzuki, Takao, additional, Miyaike, Jiro, additional, Matsubara, Minoru, additional, Takahashi, Sakuma, additional, Nishimura, Mamoru, additional, Takenaka, Ryuta, additional, Yunoki, Naoko, additional, Hori, Shinichiro, additional, Kobayashi, Sayo, additional, Yamasaki, Yasushi, additional, Kawahara, Yoshiro, additional, Ishikawa, Hideki, additional, and Okada, Hiroyuki, additional

Published
2020
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39. S1351 A Study for Every Second Day Administration of Vonoprazan in Maintenance Treatment of Erosive GERD (ESD Von GERD): A Multicenter Randomized Crossover Study

Author

Matsuda, Soichiro, primary, Kato, Mototsugu, additional, Sakakibara, Yuko, additional, Hamada, Hiroshige, additional, Sasaki, Yoshihiro, additional, Mori, Hideki, additional, Hirai, Yuichiro, additional, Inoue, Shuji, additional, Toyokawa, Tatsuya, additional, Kagaya, Takashi, additional, Kuwai, Toshio, additional, Esaka, Naoki, additional, Yamashita, Haruhiro, additional, Watanabe, Noriko, additional, Fujii, Hiroyuki, additional, Demura, Mamiko, additional, Kubo, Kimitoshi, additional, Mabe, Katsuhiro, additional, and Harada, Naohiro, additional

Published
2020
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41. Su1861 MULTICENTER SURVEY ON MESALAMINE INTOLERANCE IN PATIENTS WITH ULCERATIVE COLITIS

Author

Hiraoka, Sakiko, primary, Fujiwara, Akiko, additional, Toyokawa, Tatsuya, additional, Higashi, Reiji, additional, Moritou, Yuki, additional, Takagi, Shinjiro, additional, Matsueda, Kazuhiro, additional, Suzuki, Seiyu, additional, Miyaike, Jiro, additional, Inokuchi, Toshihiro, additional, Takahara, Masahiro, additional, Kato, Jun, additional, and Okada, Hiroyuki, additional

Published
2020
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42. Diagnostic Role of 18F-Fluorodeoxyglucose Positron Emission Tomography in Gastric Mesenchymal Tumors

Author

Iwamuro, Masaya, primary, Miyahara, Koji, additional, Sakaguchi, Chihiro, additional, Takenaka, Ryuta, additional, Kobayashi, Sayo, additional, Mouri, Hirokazu, additional, Tanaka, Shigetomi, additional, Toyokawa, Tatsuya, additional, Tanaka, Shouichi, additional, Nishimura, Mamoru, additional, Yamauchi, Kenji, additional, Tanaka, Takehiro, additional, and Okada, Hiroyuki, additional

Published
2020
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49. Risk Factors for Delayed Bleeding after Therapeutic Gastrointestinal Endoscopy in Patients Receiving Oral Anticoagulants: A Multicenter Retrospective Study

Author

Kubo, Kimitoshi, primary, Kato, Mototsugu, additional, Mabe, Katsuhiro, additional, Harada, Naohiko, additional, Iboshi, Yoichiro, additional, Kagaya, Takashi, additional, Ono, Masayoshi, additional, Toyokawa, Tatsuya, additional, Yamashita, Haruhiro, additional, Kuwai, Toshio, additional, Hamada, Hiroshige, additional, Sakakibara, Yuko, additional, Nishiyama, Hitoshi, additional, Ara, Nobuyuki, additional, Mori, Hideki, additional, Matsumoto, Mio, additional, Takahashi, Yasuo, additional, Katsushima, Shinji, additional, Watanabe, Noriko, additional, Ogura, Yoshito, additional, Saito, Hiroki, additional, Masuda, Eiji, additional, and Amano, Toraji, additional

Published
2019
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50. Long-Term Outcome in Patients with a Solitary Peutz-Jeghers Polyp

Author

Iwamuro, Masaya, primary, Aoyama, Yuki, additional, Suzuki, Seiyuu, additional, Kobayashi, Sayo, additional, Toyokawa, Tatsuya, additional, Moritou, Yuki, additional, Hori, Shinichiro, additional, Matsueda, Kazuhiro, additional, Yoshioka, Masao, additional, Tanaka, Takehiro, additional, and Okada, Hiroyuki, additional

Published
2019
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