Search

Your search keyword '"Traina-Dorge, Vicki"' showing total 181 results
Start Over Author "Traina-Dorge, Vicki"
181 results on '"Traina-Dorge, Vicki"'

3. Respiratory Syncytial Virus Infects Peripheral and Spinal Nerves and Induces Chemokine-Mediated Neuropathy.

Author

Pollard, Kevin J, Traina-Dorge, Vicki, Medearis, Stephen M, Bosak, Alexander, Bix, Gregory J, Moore, Michael J, and Piedimonte, Giovanni

Subjects
*PERIPHERAL nervous system, *SPINAL nerves, *RESPIRATORY syncytial virus, *DENDRITIC cells, *SYSTEMS on a chip
Abstract

Respiratory syncytial virus (RSV) primarily infects the respiratory epithelium, but growing evidence suggests that it may also be responsible for neurologic sequelae. In 3-dimensional microphysiologic peripheral nerve cultures, RSV infected neurons, macrophages, and dendritic cells along 2 distinct trajectories depending on the initial viral load. Low-level infection was transient, primarily involved macrophages, and induced moderate chemokine release with transient neural hypersensitivity. Infection with higher viral loads was persistent, infected neuronal cells in addition to monocytes, and induced robust chemokine release followed by progressive neurotoxicity. In spinal cord cultures, RSV infected microglia and dendritic cells but not neurons, producing a moderate chemokine expression pattern. The persistence of infection was variable but could be identified in dendritic cells as long as 30 days postinoculation. This study suggests that RSV can disrupt neuronal function directly through infection of peripheral neurons and indirectly through infection of resident monocytes and that inflammatory chemokines likely mediate both mechanisms. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

5. Simian Varicella Virus Infection and Reactivation in Rhesus Macaques Trigger Cytokine and Aβ40/42 Alterations in Serum and Cerebrospinal Fluid

Author

Niemeyer, Christy S, primary, Traina-Dorge, Vicki, additional, Doyle-Meyers, Lara, additional, Das, Arpita, additional, Looper, Jayme, additional, Mescher, Teresa, additional, Feia, Brittany, additional, Medina, Eva, additional, Nagel, Maria A., additional, Mahalingam, Ravi, additional, and Bubak, Andrew N., additional

Published
2023
Full Text
View/download PDF

7. Relationship between human T lymphotropic virus (HTLV) type 1/2 viral burden and clinical and treatment parameters among patients with HIV type 1 and HTLV-1/2 coinfection.

Author

Beilke, Mark A, Traina-Dorge, Vicki L, Sirois, Maria, Bhuiyan, Azad, Murphy, Edward L, Walls, Jane M, Fagan, Ryan, Winsor, Elsa L, and Kissinger, Patricia J

Subjects
Humans, HIV-1, HTLV-I Infections, HTLV-II Infections, HIV Infections, DNA, Viral, RNA, Messenger, CD4-CD8 Ratio, Antiretroviral Therapy, Highly Active, Viral Load, Prospective Studies, Gene Dosage, Genes, pX, Adult, Middle Aged, Female, Male, Microbiology, Biological Sciences, Medical and Health Sciences
Abstract

BACKGROUND: Human T lymphotropic virus types 1 (HTLV-1) and 2 (HTLV-2) are frequent copathogens among individuals infected with human immunodeficiency virus type 1 (HIV-1). The long-term effects of coinfection are unknown, and little information exists regarding how levels of HTLV-1/2 viral burden are affected by antiretroviral medications. METHODS: Factors associated with HTLV-1/2 viral burden were examined in patients with HIV-HTLV-1/2 coinfection. A total of 72 subjects were evaluated. The variables analyzed included HTLV-1/2 proviral load, HTLV-1/2 tax/rex mRNA expression, HIV load, HTLV-1/2 viral antigen detection in peripheral blood mononuclear cell (PBMC) cultures, T cell subsets, demographic variables (age, race, sex, and reported use of injection drugs), and administration of highly active antiretroviral therapy. RESULTS: An HTLV-1/2 proviral DNA copy number >20,000 copies/10(6) PBMCs was significantly associated with the following variables: (1) a positive HTLV-1 Western blot test result, (2) a positive HTLV-1/2 PBMC culture result, (3) a positive tax/rex mRNA result, (4) an HIV load

Published
2007

8. Recombinant Simian Varicella Virus-Simian Immunodeficiency Virus Vaccine Induces T and B Cell Functions and Provides Partial Protection against Repeated Mucosal SIV Challenges in Rhesus Macaques

Author

Pahar, Bapi, primary, Gray, Wayne, additional, Fahlberg, Marissa, additional, Grasperge, Brooke, additional, Hunter, Meredith, additional, Das, Arpita, additional, Mabee, Christopher, additional, Aye, Pyone Pyone, additional, Schiro, Faith, additional, Hensley, Krystle, additional, Ratnayake, Aneeka, additional, Goff, Kelly, additional, LaBranche, Celia, additional, Shen, Xiaoying, additional, Tomaras, Georgia D., additional, DeMarco, C. Todd, additional, Montefiori, David, additional, Kissinger, Patricia, additional, Marx, Preston A., additional, and Traina-Dorge, Vicki, additional

Published
2022
Full Text
View/download PDF

10. Simian Varicella Virus Pathogenesis in Skin during Varicella and Zoster

Author

Mahalingam, Ravi, primary, Feia, Brittany, additional, Coleman, Colin, additional, Anupindi, Kusala, additional, Saravanan, Pratush, additional, Luthens, Amalia, additional, Bustillos, Amalia, additional, Das, Arpita, additional, de Haro, Eileen, additional, Doyle-Meyers, Lara, additional, Looper, Jayme, additional, Bubak, Andrew N., additional, Niemeyer, Christy S., additional, Palmer, Brent, additional, Nagel, Maria A., additional, and Traina-Dorge, Vicki, additional

Published
2022
Full Text
View/download PDF

11. Pulmonary and Neurological Effects of SARS-CoV-2 and Respiratory Syncytial Virus Co-infection in Adenovirus-mediated Pulmonary Expression of Human Angiotensin Converting Enzyme 2 Receptor

Author

Gebara, Marc, Gressett, Timothy E, Brown, Ryan, Amruta Narayanappa, Chen, Zheng, Midkiff, Cecily C, Parades, Solange, Das, Arpita, Dugas, Courtney M, Thompson, Carli, Chandler, Kristin, Bavaret, Tammy, Birnbaum, Angela, Blair, Robert V, Sato, Ryosuke, Traina-Dorge, Vicki L, Xuebing Qin, Piedimonte, Giovanni, and Bix, Gregory

Published
2022
Full Text
View/download PDF

23. An enzyme‐linked immunosorbent assay (ELISA) to determine Simian Varicella Virus antibody titers in infected rhesus monkeys (Macaca mulatta).

Author

Gray, Wayne L., Wichman, Grant, Das, Arpita, and Traina‐Dorge, Vicki

Subjects
RHESUS monkeys, ANTIBODY titer, VIRAL antibodies, SIMIAN viruses, VARICELLA-zoster virus, MACAQUES
Abstract

Background: Simian varicella virus (SVV) is a primate herpesvirus that causes a natural varicella‐like disease in Old World monkeys and may cause epizootics in facilities housing nonhuman primates. SVV infection of nonhuman primates is used as an experimental model to investigate varicella pathogenesis and to develop antiviral strategies. Methods: An indirect enzyme‐linked immunosorbent assay (ELISA) was developed to detect SVV antibodies in infected rhesus macaque monkeys. Results: An ELISA determined SVV antibody titers following experimental infection. SVV IgG was detected by day 14 post‐infection and remained elevated for at least 84 days. Conclusions: The SVV ELISA is a safe and rapid approach to confirm SVV seropositivity and to determine SVV antibody titers in naturally and experimentally SVV‐infected monkeys. In addition to being a useful diagnostic assay to rapidly confirm acute disease or past SVV infection, the SVV ELISA is a valuable epidemiological tool to determine the incidence of SVV in non‐human primate facilities. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

26. Increased cellular immune responses and CD4+ T-cell proliferation correlate with reduced plasma viral load in SIV challenged recombinant simian varicella virus - simian immunodeficiency virus (rSVV-SIV) vaccinated rhesus macaques

Author

Pahar Bapi, Gray Wayne L, Phelps Kimberly, Didier Elizabeth S, deHaro Eileen, Marx Preston A, and Traina-Dorge Vicki L

Subjects
Simian varicella virus (SVV), Simian immunodeficiency virus (SIV), T-cells, Cytokine, Memory, Proliferation, Vaccine, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background An effective AIDS vaccine remains one of the highest priorities in HIV-research. Our recent study showed that vaccination of rhesus macaques with recombinant simian varicella virus (rSVV) vector – simian immunodeficiency virus (SIV) envelope and gag genes, induced neutralizing antibodies and cellular immune responses to SIV and also significantly reduced plasma viral loads following intravenous pathogenic challenge with SIVMAC251/CX1. Findings The purpose of this study was to define cellular immunological correlates of protection in rSVV-SIV vaccinated and SIV challenged animals. Immunofluorescent staining and multifunctional assessment of SIV-specific T-cell responses were evaluated in both Experimental and Control vaccinated animal groups. Significant increases in the proliferating CD4+ T-cell population and polyfunctional T-cell responses were observed in all Experimental-vaccinated animals compared with the Control-vaccinated animals. Conclusions Increased CD4+ T-cell proliferation was significantly and inversely correlated with plasma viral load. Increased SIV-specific polyfunctional cytokine responses and increased proliferation of CD4+ T-cell may be crucial to control plasma viral loads in vaccinated and SIVMAC251/CX1 challenged macaques.

Published
2012
Full Text
View/download PDF

27. Current In Vivo Models of Varicella-Zoster Virus Neurotropism

Author

Mahalingam, Ravi, primary, Gershon, Anne, additional, Gershon, Michael, additional, Cohen, Jeffrey I., additional, Arvin, Ann, additional, Zerboni, Leigh, additional, Zhu, Hua, additional, Gray, Wayne, additional, Messaoudi, Ilhem, additional, and Traina-Dorge, Vicki, additional

Published
2019
Full Text
View/download PDF

28. A virus-like particle vaccine prevents equine encephalitis virus infection in nonhuman primates

Author

Ko, Sung-Youl, primary, Akahata, Wataru, additional, Yang, Eun Sung, additional, Kong, Wing-Pui, additional, Burke, Crystal W., additional, Honnold, Shelley P., additional, Nichols, Donald K., additional, Huang, Yan-Jang S., additional, Schieber, Gretchen L., additional, Carlton, Kevin, additional, DaSilva, Luis, additional, Traina-Dorge, Vicki, additional, Vanlandingham, Dana L., additional, Tsybovsky, Yaroslav, additional, Stephens, Tyler, additional, Baxa, Ulrich, additional, Higgs, Stephen, additional, Roy, Chad J., additional, Glass, Pamela J., additional, Mascola, John R., additional, Nabel, Gary J., additional, and Rao, Srinivas S., additional

Published
2019
Full Text
View/download PDF

34. Attenuation of Simian Varicella Virus Infection by Enhanced Green Fluorescent Protein in Rhesus Macaques

Author

Mahalingam, Ravi, primary, Kaufer, Benedikt B., additional, Ouwendijk, Werner J. D., additional, Verjans, Georges M. G. M., additional, Coleman, Colin, additional, Hunter, Meredith, additional, Das, Arpita, additional, Palmer, Brent E., additional, Clambey, Eric, additional, Nagel, Maria A., additional, and Traina-Dorge, Vicki, additional

Published
2018
Full Text
View/download PDF

35. Reactivation of Simian Varicella Virus (SVV) in Rhesus Macaques After CD4 T Cell Depletion.

Author

Traina-Dorge, Vicki, Palmer, Brent E., Coleman, Colin, Hunter, Meredith, Frieman, Amy, Gilmore, Anah, Altrock, Karen, Doyle-Meyers, Lara, Nagel, Maria A., and Mahalingam, Ravi

Subjects
*VARICELLA-zoster virus, *RHESUS monkeys, *CD4 antigen, *T cells, *IMMUNOFLUORESCENCE
Abstract

Rhesus macaques intrabronchially inoculated with simian varicella virus (SVV), the counterpart of human varicella zoster virus (VZV), developed primary infection with viremia and rash, which resolved upon clearance of viremia followed by establishment of latency. To assess the role of CD4 T cell immunity in reactivation, monkeys were treated with a single 50 mg/kg dose of a humanized monoclonal anti-CD4 antibody; within 1 week, circulating CD4 T cells were reduced from 40-60% to 5-30% of the total cell population and remained low for 2 months. Very low viremia was seen only in some of the treated monkeys. Zoster rash developed after 7 days in the monkey with the most extensive CD4 T cell depletion (5%) and in all other monkeys at 10-49 days post treatment, with recurrent zoster in one treated monkey. SVV DNA was detected in the lung from 2 of 5 monkeys, in bronchial lymph nodes from 1 of the 5 monkeys, and in ganglia from at least two dermatomes in 3 of 5 monkeys. Immunofluorescence analysis of skin rash, lung, lymph node and ganglia revealed SVV ORF 63 protein in: sweat glands in skin; type II cells in lung alveoli, macrophages and dendritic cells in lymph nodes, and the neuronal cytoplasm of ganglia. Detection of SVV antigen in multiple tissues upon CD4 T cell depletion and virus reactivation suggests a critical role for CD4 T cell immunity in controlling varicella virus latency. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

36. Simian Varicella Virus Is Present in Macrophages, Dendritic Cells, and T Cells in Lymph Nodes of Rhesus Macaques after Experimental Reactivation

Author

Traina-Dorge, Vicki, primary, Doyle-Meyers, Lara A., additional, Sanford, Robert, additional, Manfredo, Jennifer, additional, Blackmon, Anna, additional, Wellish, Mary, additional, James, Stephanie, additional, Alvarez, Xavier, additional, Midkiff, Cecily, additional, Palmer, Brent E., additional, Deharo, Eileen, additional, Gilden, Don, additional, and Mahalingam, Ravi, additional

Published
2015
Full Text
View/download PDF

38. T-Cell Infiltration Correlates with CXCL10 Expression in Ganglia of Cynomolgus Macaques with Reactivated Simian Varicella Virus

Author

Ouwendijk, Werner J. D., primary, Abendroth, Allison, additional, Traina-Dorge, Vicki, additional, Getu, Sarah, additional, Steain, Megan, additional, Wellish, Mary, additional, Andeweg, Arno C., additional, Osterhaus, Albert D. M. E., additional, Gilden, Don, additional, Verjans, Georges M. G. M., additional, and Mahalingam, Ravi, additional

Published
2013
Full Text
View/download PDF

45. Simian varicella virus reactivation in cynomolgus monkeys

Author

Mahalingam, Ravi, primary, Traina-Dorge, Vicki, additional, Wellish, Mary, additional, Lorino, Rebecca, additional, Sanford, Robert, additional, Ribka, Erin P., additional, Alleman, Scott J., additional, Brazeau, Elizabeth, additional, and Gilden, Donald H., additional

Published
2007
Full Text
View/download PDF

50. Molecular Epidemiology of Simian Immunodeficiency Virus SIVsm in U.S. Primate Centers Unravels the Origin of SIVmac and SIVstm

Author

Apetrei, Cristian, primary, Kaur, Amitinder, additional, Lerche, Nicholas W., additional, Metzger, Michael, additional, Pandrea, Ivona, additional, Hardcastle, Johnny, additional, Falkenstein, Shelley, additional, Bohm, Rudolf, additional, Koehler, Jeffrey, additional, Traina-Dorge, Vicki, additional, Williams, Tessa, additional, Staprans, Silvija, additional, Plauche, Gail, additional, Veazey, Ronald S., additional, McClure, Harold, additional, Lackner, Andrew A., additional, Gormus, Bobby, additional, Robertson, David L., additional, and Marx, Preston A., additional

Published
2005
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results