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5. A high sensitivity wide bandwidth spectral system for multiple K-edge imaging

Author

Perion, P., Brombal, L., Delogu, P., di Trapani, V., Menk, Ralf Hendrik, Oliva, P., Arfelli, F., Perion, P., Brombal, L., Delogu, P., di Trapani, V., Menk, Ralf Hendrik, Oliva, P., and Arfelli, F.

Abstract

Spectral K-edge subtraction (SKES) is an imaging technique that takes advantage of the sharp rise in the mass attenuation coefficient of specific elements within an object at their K-edge to produce separate and quantifiable distributions of each element. In this paper, a high-sensitivity and wide bandwidth SKES imaging system for computed tomography applications on biological samples is presented. X-ray images are acquired using a wide and continuous energy spectrum that encompasses the absorption edges of the target materials. System characterization shows that high energy resolution (approximately 3 × 10 − 3 ) and unprecedented large energy bandwidth (around 15%) are achieved over a field-of-view of several centimeters. Imaging results obtained on contrast elements relevant for biomedical applications, namely silver, iodine, xenon, and barium, demonstrate the system sensitivity to concentrations down to 0.5 mg ml−1. The achievement of a large energy bandwidth allowed the simultaneous imaging of the K-edges of iodine, xenon, and barium and provided an accurate concentration estimation and distinction of co-localized contrast elements, leading the way for future simultaneous cardiovascular (iodine), pulmonary (xenon), and gastrointestinal/inflammatory (barium) imaging applications.

Published
2024
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7. Towards In Vivo K-Edge X-Ray Micro-CT with the Pixirad-I/Pixie-III Detector

Author

Brun, F., Di Trapani, V., Dreossi, D., Rigon, L., Longo, R., Delogu, P., Magjarevic, Ratko, Editor-in-Chief, Ładyżyński, Piotr, Series Editor, Ibrahim, Fatimah, Series Editor, Lacković, Igor, Series Editor, Rock, Emilio Sacristan, Series Editor, Lhotska, Lenka, editor, Sukupova, Lucie, editor, and Ibbott, Geoffrey S., editor

Published
2019
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8. Communication Design for the Dissemination of Scientific Knowledge. Languages, Tools, Technologies, Collaborative Processes for Museum Education

Author

Trapani, V. M. Viviana, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, and Luigini, Alessandro, editor

Published
2019
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11. Unified Modulation Pattern Analysis (UMPA) algorithm for 1D sensitive X-ray phase contrast imaging techniques

Author

Di Trapani, V., Brombal, L., De Marco, F., Dreossi, D., Thibault, P., Di Trapani, V., Brombal, L., De Marco, F., Dreossi, D., and Thibault, P.

Subjects
Multi-modality systems, Simulation methods and programs, X-ray radiography and digital radiography (DR), Simulation methods and program, Instrumentation, Mathematical Physics, Multi-modality system
Abstract

X-ray phase contrast imaging (XPCI) techniques are sensitive to refraction (differential-phase) and small-angle X-ray scattering (dark-field) signals, not measurable with conventional absorption imaging techniques. Among XPCI techniques, edge illumination (EI), grating interferometry (GI), and speckle-based imaging (SBI) make use of wavefront markers, such as absorbing masks with periodical apertures or random diffusers, to encode refraction and dark-field signals induced by the sample. The Unified Modulated Pattern Analysis (UMPA) provides an algorithmic solution to extract the transmission, refraction, and dark-field images from EI, GI, and SBI datasets where the wavefront marker is directly resolved by the employed detection system. In its original implementation, UMPA has been designed for XPCI techniques sensitive to refractions along two axes. This work presents a modified version of the algorithm to extend its applicability to all the existing XPCI techniques that use wavefront markers with sensitivity to refraction limited along one direction (UMPA-1D). The algorithm, written in C++ and Cython and parallelized with OpenMP, enables fast reconstruction times that are particularly convenient for large tomographic datasets. The validity of the UMPA-1D has been demonstrated using both simulated images and real acquisitions with an EI setup in beam-tracking mode.

Published
2023

12. Validation of Esaso Classification of Diabetic Maculopathy

Author

Panozzo, G., Franzolin, E., Giannarelli, Diana, Dalla Mura, G., Longo, Anita Rosa, Cicinelli, M. V., Angelini, E., Airaghi, P., Avitabile, T., Bandello, F., Beccastrini, A., Benedetti, G., Bertuzzi, Paolo Francesco, Bonfiglio, V. M. E., Boscia, F., Carnevali, A., Carosielli, M., Cereda, M. G., Contardi, C., Coppola, M., Costagliola, C., Cristofolini, R., Cucciniello, P., D'Aloisio, R., De Bernardo, M., De Filippis, Alessandro, Dell'Omo, Roberto, Di Paola, I., Dell'Acqua, Massimiliano, Franco, Alessio, Grassi, M. O., Gregori, G., Gusson, E., Lattanzio, R., Lanzetta, P., Longo, A., Marchini, G., Marolo, P., Mastropasqua, R., Bertoldo, G. M., Monteleone, Giorgio, Ortisi, E., Parisi, Giuseppe, Parrulli, S., Pucci, P., Pastore, M. R., Reibaldi, M., Rizzo, Stanislao, Romano, Federica, Rosa, N., Sarao, V., Scarpa, G., Scorcia, V., Scupola, Andrea, Staurenghi, G., Sunseri Trapani, V., Tognetto, D., Trabucchi, G., Vaccaro, S., Vadala, M., Veritti, D., Vinciguerra, A. L., Zanzottera, E. C., Giannarelli D., Longo R., Bertuzzi F., De Filippis A., Dell'Omo R., Dell'Acqua M., Franco A., Monteleone G., Parisi G., Rizzo S. (ORCID:0000-0001-6302-063X), Romano F., Scupola A., Panozzo, G., Franzolin, E., Giannarelli, Diana, Dalla Mura, G., Longo, Anita Rosa, Cicinelli, M. V., Angelini, E., Airaghi, P., Avitabile, T., Bandello, F., Beccastrini, A., Benedetti, G., Bertuzzi, Paolo Francesco, Bonfiglio, V. M. E., Boscia, F., Carnevali, A., Carosielli, M., Cereda, M. G., Contardi, C., Coppola, M., Costagliola, C., Cristofolini, R., Cucciniello, P., D'Aloisio, R., De Bernardo, M., De Filippis, Alessandro, Dell'Omo, Roberto, Di Paola, I., Dell'Acqua, Massimiliano, Franco, Alessio, Grassi, M. O., Gregori, G., Gusson, E., Lattanzio, R., Lanzetta, P., Longo, A., Marchini, G., Marolo, P., Mastropasqua, R., Bertoldo, G. M., Monteleone, Giorgio, Ortisi, E., Parisi, Giuseppe, Parrulli, S., Pucci, P., Pastore, M. R., Reibaldi, M., Rizzo, Stanislao, Romano, Federica, Rosa, N., Sarao, V., Scarpa, G., Scorcia, V., Scupola, Andrea, Staurenghi, G., Sunseri Trapani, V., Tognetto, D., Trabucchi, G., Vaccaro, S., Vadala, M., Veritti, D., Vinciguerra, A. L., Zanzottera, E. C., Giannarelli D., Longo R., Bertuzzi F., De Filippis A., Dell'Omo R., Dell'Acqua M., Franco A., Monteleone G., Parisi G., Rizzo S. (ORCID:0000-0001-6302-063X), Romano F., and Scupola A.

Abstract

Purpose: To test reliability and reproducibility of ESASO morphologic OCT-based classification of diabetic maculopathy (DM). Methods: This is a multi-center cross-sectional study including a coordination center (CC) and 18 participating centers (PCs). After instruction on the correct use of ESASO Classification, the validation process was carried out in two consecutive stages. In the first retrospective phase, we evaluated the concordance between PCs and CC in the staging of OCT images collected during PCs’ daily activity (608 images). In a second prospective phase, we analyzed the inter-observer agreement of staging assigned by each PCs to OCT images selected by the CC (22 images). Results: The overall concordance achieved in the retrospective phase was 89.8% (Kappa = 0.83 (95% CI: 0.78–0.87); p<0.0001). In 99.5% of cases, concordance did not differ by more than one stage. In the prospective phase, PCs reached an inter-operator agreement of 93.0% (Krippendorff's Alpha = 0.953, 95% CI: 0.929–0.977, p<0.0001). Any discrepancy among the 22 images was within one stage. Conclusion: The results achieved in this study confirm that ESASO OCT-based Classification can be considered as an easy and reproducible method to stage DM during clinical practice. A diffused use of a common and validated method to describe the progression of retinal damage in DM may offer several clinical and scientific advantages.

Published
2023

19. Optimization of a customized simultaneous algebraic reconstruction technique algorithm for phase-contrast breast computed tomography

Author

Donato, S, primary, Brombal, L, additional, Arana Peña, L M, additional, Arfelli, F, additional, Contillo, A, additional, Delogu, P, additional, Di Lillo, F, additional, Di Trapani, V, additional, Fanti, V, additional, Longo, R, additional, Oliva, P, additional, Rigon, L, additional, Stori, L, additional, Tromba, G, additional, and Golosio, B, additional

Published
2022
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20. A Real-World Study of Dexamethasone Implant in Treatment-Naïve Patients with Diabetic Macular Edema: Efficacy and Correlation Between Inflammatory Biomarkers and Treatment Outcome

Author

Vadalà M, Sunseri Trapani V, Guarrasi G, Ventura N, Castellucci M, and Cillino S

Subjects
real-world, Ophthalmology, intravitreal implants, genetic structures, inflammation, dexamethasone implant, RE1-994, diabetic macular edema, ozurdex, eye diseases
Abstract

Maria Vadalà,1,2 Valentina Sunseri Trapani,1 Giulia Guarrasi,1 Nicasio Ventura,1 Massimo Castellucci,1 Salvatore Cillino1 1Biomedicine, Neuroscience and Advanced Diagnostic Department, University of Palermo, Palermo, Italy; 2IEMEST, Euro-Mediterranean Institute of Science and Technology, Palermo, ItalyCorrespondence: Maria VadalàBiomedicine, Neuroscience and Advanced Diagnostic (BIND) Department, Ophthalmology Institute, University of Palermo, Palermo 90127, ItalyTel +39 091 6553909Email maria.vadala@unipa.itPurpose: There has been an increasing clinical interest in specific retinal parameters as non-invasive biomarkers of retinal inflammation in diabetic macular edema (DME) that have been shown to have prognostic value, such as hyperreflective retinal fields (HRFs) and subfoveal neuroretinal detachment (SND).Methods: We conducted a prospective, non-comparative study of treatment-naïve patients with DME to evaluate the efficacy of a Pro Re Nata (PRN) regimen of intravitreal dexamethasone implant 0.7 mg (DexI, Ozurdex™). After administration, patients underwent subsequent injections according to PRN criteria in case of edema relapse, but not earlier than 4 months after the previous treatment. Patients were evaluated at baseline, within 15 days of injection, and every month thereafter. During all visits, best-corrected visual acuity (BCVA) was recorded; central retinal thickness (CRT), type of edema, presence of SND, and presence and number of HRFs were evaluated using swept-source optical coherence tomography (SS-OCT) 3D. Treatment outcome was defined as changes in BCVA, CRT, SND and HRFs at 12 (T12) and 24 (T24) months compared with baseline (T0).Results: The study enrolled 24 eyes of 18 patients. The mean duration of follow-up was 18± 6.6 months; for all eyes, T12 data were available, while follow-up reached T24 for 12 eyes. BCVA improved significantly and CRT decreased significantly during treatment; the edema was no longer detectable in 13/24 eyes at T12 and 8/12 eyes at T24. No patient presented SND at T12 and T24, and the mean number of HRFs decreased significantly during treatment. Results with CRT and HRFs correlated with BCVA at 12 and 24 months. No significant adverse events were observed.Conclusion: In patients with DME, the intravitreal dexamethasone implant was effective and safe in improving both functional and tomographic parameters. This result is consistent with improvement in biomarkers of inflammation.Keywords: dexamethasone implant, diabetic macular edema, intravitreal implants, Ozurdex, real-world, inflammation

Published
2020

21. Dietary magnesium alleviates experimental murine colitis through modulation of gut microbiota

Author

Del Chierico, F., Trapani, Valentina, Petito, Valentina, Reddel, S., Pietropaolo, G., Graziani, C., Masi, L., Gasbarrini, Antonio, Putignani, Lorenza, Scaldaferri, Franco, Wolf Minotti, Federica, Trapani V. (ORCID:0000-0002-0259-6624), Petito V., Gasbarrini A. (ORCID:0000-0002-7278-4823), Putignani L., Scaldaferri F. (ORCID:0000-0001-8334-7541), Wolf F. (ORCID:0000-0003-1361-1049), Del Chierico, F., Trapani, Valentina, Petito, Valentina, Reddel, S., Pietropaolo, G., Graziani, C., Masi, L., Gasbarrini, Antonio, Putignani, Lorenza, Scaldaferri, Franco, Wolf Minotti, Federica, Trapani V. (ORCID:0000-0002-0259-6624), Petito V., Gasbarrini A. (ORCID:0000-0002-7278-4823), Putignani L., Scaldaferri F. (ORCID:0000-0001-8334-7541), and Wolf F. (ORCID:0000-0003-1361-1049)

Abstract

Nutritional deficiencies are common in inflammatory bowel diseases (IBD). In patients, magnesium (Mg) deficiency is associated with disease severity, while in murine models, dietary Mg supplementation contributes to restoring mucosal function. Since Mg availability modulates key bacterial functions, including growth and virulence, we investigated whether the beneficial effects of Mg supplementation during colitis might be mediated by gut microbiota. The effects of dietary Mg modulation were assessed in a murine model of dextran sodium sulfate (DSS)-induced colitis by monitoring magnesemia, weight, and fecal consistency. Gut microbiota were analyzed by 16S-rRNA based profiling on fecal samples. Mg supplementation improved microbiota richness in colitic mice, increased abundance of Bifidobacterium and reduced Enterobacteriaceae. KEEG pathway analysis predicted an increase in biosynthetic metabolism, DNA repair and translation pathways during Mg supplementation and in the presence of colitis, while low Mg conditions favored catabolic processes. Thus, dietary Mg supplementation increases bacteria involved in intestinal health and metabolic homeostasis, and reduces bacteria involved in inflammation and associated with human diseases, such as IBD. These findings suggest that Mg supplementation may be a safe and cost-effective strategy to ameliorate disease symptoms and restore a beneficial intestinal flora in IBD patients.

Published
2021

22. The magnesium global network (MaGNet) to promote research on magnesium in diseases focusing on covid-19

Author

Wolf, F. I., Maier, J. A., Rosanoff, A., Barbagallo, M., Baniasadi, S., Castiglioni, S., Cheng, F. -C., Day, S. C., Costello, R. B., Dominguez, L. J., Elin, R. J., Gamboa-Gomez, C., Guerrero-Romero, F., Kahe, K., Kisters, K., Kolisek, M., Kraus, A., Iotti, S., Mazur, A., Mercado-Atri, M., Merolle, L., Micke, O., Gletsu-Miller, N., Nielsen, F., O-Uchi, J., Piazza, O., Plesset, M., Pourdowlat, G., Rios, F. J., Rodriguez-Moran, M., Scarpati, G., Shechter, M., Song, Y., Spence, L. A., Touyz, R. M., Trapani, Valentina, Veronese, N., Von Ehrlich, B., Vormann, J., Wallace, T. C., Trapani V. (ORCID:0000-0002-0259-6624), Wolf, F. I., Maier, J. A., Rosanoff, A., Barbagallo, M., Baniasadi, S., Castiglioni, S., Cheng, F. -C., Day, S. C., Costello, R. B., Dominguez, L. J., Elin, R. J., Gamboa-Gomez, C., Guerrero-Romero, F., Kahe, K., Kisters, K., Kolisek, M., Kraus, A., Iotti, S., Mazur, A., Mercado-Atri, M., Merolle, L., Micke, O., Gletsu-Miller, N., Nielsen, F., O-Uchi, J., Piazza, O., Plesset, M., Pourdowlat, G., Rios, F. J., Rodriguez-Moran, M., Scarpati, G., Shechter, M., Song, Y., Spence, L. A., Touyz, R. M., Trapani, Valentina, Veronese, N., Von Ehrlich, B., Vormann, J., Wallace, T. C., and Trapani V. (ORCID:0000-0002-0259-6624)

Abstract

Not available

Published
2021

23. The relevance of magnesium homeostasis in COVID-19

Author

Trapani, Valentina, Rosanoff, A., Baniasadi, S., Barbagallo, M., Castiglioni, S., Guerrero-Romero, F., Iotti, S., Mazur, A., Micke, O., Pourdowlat, G., Scarpati, G., Wolf, F. I., Maier, J. A., Trapani V. (ORCID:0000-0002-0259-6624), Trapani, Valentina, Rosanoff, A., Baniasadi, S., Barbagallo, M., Castiglioni, S., Guerrero-Romero, F., Iotti, S., Mazur, A., Micke, O., Pourdowlat, G., Scarpati, G., Wolf, F. I., Maier, J. A., and Trapani V. (ORCID:0000-0002-0259-6624)

Abstract

Purpose: In less than one and a half year, the COVID-19 pandemic has nearly brought to a collapse our health care and economic systems. The scientific research community has concentrated all possible efforts to understand the pathogenesis of this complex disease, and several groups have recently emphasized recommendations for nutritional support in COVID-19 patients. In this scoping review, we aim at encouraging a deeper appreciation of magnesium in clinical nutrition, in view of the vital role of magnesium and the numerous links between the pathophysiology of SARS-CoV-2 infection and magnesium-dependent functions. Methods: By searching PubMed and Google Scholar from 1990 to date, we review existing evidence from experimental and clinical studies on the role of magnesium in chronic non-communicable diseases and infectious diseases, and we focus on recent reports of alterations of magnesium homeostasis in COVID-19 patients and their association with disease outcomes. Importantly, we conduct a census on ongoing clinical trials specifically dedicated to disclosing the role of magnesium in COVID-19. Results: Despite many methodological limitations, existing data seem to corroborate an association between deranged magnesium homeostasis and COVID-19, and call for further and better studies to explore the prophylactic or therapeutic potential of magnesium supplementation. Conclusion: We propose to reconsider the relevance of magnesium, frequently overlooked in clinical practice. Therefore, magnesemia should be monitored and, in case of imbalanced magnesium homeostasis, an appropriate nutritional regimen or supplementation might contribute to protect against SARS-CoV-2 infection, reduce severity of COVID-19 symptoms and facilitate the recovery after the acute phase.

Published
2021

24. L'ecomuseo del grano e del pane: un percorso progettuale centrato sul design

Author

Trapani V., Maiorana G., Maiorana, G, Trapani, V, Lotta, F., and Trapani V.

Subjects
The feast of St. Joseph, as well as an important and heartfelt religious celebration, is in Salemi above all the "feast of the loaves", beautiful achievements of high artistic craftsmanship, whose wisdom is handed down in the families and in the associations of women who for many months work to produce the enormous quantity of small and large forms of bread, to cover the votive constructions that welcome the ritual of dinner.Thus the idea of proposing an "Ecomuseum of wheat and bread" in the Jesuit College was born, enhancing and re-opening a space of great historical-architectural interest to the public. As part of the consolidated collaboration of the Municipality of Salemi with the Department of Architecture, professors and students worked on a strategic design project for museum set-up and communication, also open forms of participation and sharing with the various territorial actors, in a sort of 'social conversation' with the protagonists and skills in the field. A collaboration with Polimi Desis_Lab of the Milan Polytechnic concerning the contribution of the 'design of services for social innovation' was also initiated on these aspects, Settore ICAR/13 - Disegno Industriale
Abstract

La festa di S. Giuseppe, oltre che un’importante e sentita ricorrenza religiosa, è a Salemi soprattutto la “festa dei pani”; bellissime realizzazioni di alto artigianato artistico, la cui sapienza si tramanda nelle famiglie e nelle associazioni di donne che per mesi lavorano alla produzione dell’enorme quantità delle piccole e grandi forme di pane, per rivestire le costruzioni votive che accolgono il rito della cena. Nasce quindi l’idea di proporre un “Ecomuseo del grano e del pane” nel Collegio dei Gesuiti, valorizzando e riaprendo al pubblico uno spazio di grande interesse storico-architettonico. Nell’ambito della consolidata collaborazione del Comune di Salemi con il Dipartimento di Architettura, docenti e studenti hanno lavorato ad un progetto di design strategico per l’allestimento e la comunicazione museale, aperto anche forme di partecipazione e condivisione con i diversi attori territoriali, in una sorta di ‘conversazione sociale’ con i protagonisti e le competenze in campo. Su questi aspetti è stata avviata anche una collaborazione con il Polimi Desis_Lab del Politecnico di Milano inerente l’apporto del ‘design dei servizi per l’innovazione sociale’.

Published
2018

26. Characterization of noise and efficiency of the Pixirad-1/Pixie-III CdTe X-ray imaging detector

Author

Di Trapani, V, Bravin, A, Brun, F, Dreossi, D, Longo, R, Mittone, A, Rigon, L, Deloguad, P, Di Trapani V, Bravin A, Brun F, Dreossi D, Longo R, Mittone A, Rigon L, Deloguad P, Di Trapani, V, Bravin, A, Brun, F, Dreossi, D, Longo, R, Mittone, A, Rigon, L, Deloguad, P, Di Trapani V, Bravin A, Brun F, Dreossi D, Longo R, Mittone A, Rigon L, and Deloguad P

Abstract

Thanks to their high detection efficiency and low intrinsic noise, direct conversion X-ray Photon Counting Detectors (XPCDs) are particularly suitable for low dose imaging applications such as mammography. The photon counting technology can implement also two or more acquisition thresholds to perform single-shot spectral imaging with one polychromatic source. However, XPCDs with thick high Z crystal sensor and small pixel size are affected by the charge sharing effect. This issue can induce multiple counts from a single interaction reducing both spectral and spatial resolutions. In a pure counting mode, multiple counts from charge sharing can be partially or totally removed by increasing the acquisition threshold at the cost of a loss of efficiency. Thus, the performances of XPCDs can be threshold-dependent. New generation XPCDs implement solutions to cope with charge sharing issue. If the charge sharing is properly corrected, no multiple counts are recorded and the performances (detection efficiency, spectral and spatial resolutions) of the acquisition system are expected to be independent from the acquisition threshold. This work presents a study of a Pixirad-1 detection system based on a CdTe Schottky sensor and PIXIE-III readout system. This chip can be configured in three different operation modes, two of which implement solutions to remove multiple counts. Using monochromatic radiation, the performances of these different operation modes have been compared trough a measure of the integral spectra and the Signal to Noise Ratio (SNR) as function of the acquisition threshold.

Published
2018

29. Single-shot K-edge subtraction x-ray discrete computed tomography with a polychromatic source and the Pixie-III detector

Author

Brun, F, Di Trapani, V, Albers, J, Sacco, P, Dreossi, D, Brombal, L, Rigon, L, Longo, R, Mittone, A, Dullin, C, Bravin, A, Delogu, P, Brun, Francesco, Di Trapani, Vittorio, Albers, Jonas, Sacco, Pasquale, Dreossi, Diego, Brombal, Luca, Rigon, Luigi, Longo, Renata, Mittone, Alberto, Dullin, Christian, Bravin, Alberto, Delogu, Pasquale, Brun, F, Di Trapani, V, Albers, J, Sacco, P, Dreossi, D, Brombal, L, Rigon, L, Longo, R, Mittone, A, Dullin, C, Bravin, A, Delogu, P, Brun, Francesco, Di Trapani, Vittorio, Albers, Jonas, Sacco, Pasquale, Dreossi, Diego, Brombal, Luca, Rigon, Luigi, Longo, Renata, Mittone, Alberto, Dullin, Christian, Bravin, Alberto, and Delogu, Pasquale

Abstract

K-edge subtraction (KES) imaging is a technique able to map a specific element such as e.g. a contrast agent within the tissues, by exploiting the sharp rise of its absorption coefficient at the K-edge energy. Whereas mainly explored at synchrotron radiation sources, the energy discrimination properties of modern x-ray photon counting detectors (XPCDs) pave the way for an implementation of single-shot KES imaging with conventional polychromatic sources. In this work we present an x-ray CT imaging system based on the innovative Pixie-III detector and discrete reconstruction. The results reported here show that a reliable automatic localization of Barium (above a certain concentration) is possible with a few dozens of tomographic projections for a volume having an axial slice of 512 [Formula: see text] 512 pixels. The final application is a routine high-fidelity 3D mapping of a specific element ready for further morphological quantification by means of x-ray CT with potential promising applications in vivo.

Published
2020

30. Magnesium Absorption in Intestinal Cells: Evidence of Cross-Talk between EGF and TRPM6 and Novel Implications for Cetuximab Therapy

Author

Pietropaolo, G., Pugliese, Daniela, Armuzzi, Alessandro, Guidi, Luisa, Gasbarrini, Antonio, Rapaccini, Gian Ludovico, Wolf Minotti, Federica, Trapani, Valentina, Pugliese, D., Armuzzi A. (ORCID:0000-0003-1572-0118), Guidi, L. (ORCID:0000-0003-3320-7094), Gasbarrini, A. (ORCID:0000-0002-7278-4823), Rapaccini, G. L. (ORCID:0000-0002-6467-857X), Wolf, F. (ORCID:0000-0003-1361-1049), Trapani, V. (ORCID:0000-0002-0259-6624), Pietropaolo, G., Pugliese, Daniela, Armuzzi, Alessandro, Guidi, Luisa, Gasbarrini, Antonio, Rapaccini, Gian Ludovico, Wolf Minotti, Federica, Trapani, Valentina, Pugliese, D., Armuzzi A. (ORCID:0000-0003-1572-0118), Guidi, L. (ORCID:0000-0003-3320-7094), Gasbarrini, A. (ORCID:0000-0002-7278-4823), Rapaccini, G. L. (ORCID:0000-0002-6467-857X), Wolf, F. (ORCID:0000-0003-1361-1049), and Trapani, V. (ORCID:0000-0002-0259-6624)

Abstract

Hypomagnesemia is very commonly observed in cancer patients, most frequently in association with therapy with cetuximab (CTX), a monoclonal antibody targeting the epithelial growth factor receptor (EGFR). CTX-induced hypomagnesemia has been ascribed to renal magnesium (Mg) wasting. Here, we sought to clarify whether CTX may also influence intestinal Mg absorption and if Mg supplementation may interfere with CTX activity. We used human colon carcinoma CaCo-2 cells as an in vitro model to study the mechanisms underlying Mg transport and CTX activity. Our findings demonstrate that TRPM6 is the key channel that mediates Mg influx in intestinal cells and that EGF stimulates such influx; consequently, CTX downregulates TRPM6-mediated Mg influx by interfering with EGF signaling. Moreover, we show that Mg supplementation does not modify either the CTX IC50 or CTX-dependent inhibition of ERK1/2 phosphorylation. Our results suggest that reduced Mg absorption in the intestine may contribute to the severe hypomagnesemia that occurs in CTX-treated patients, and Mg supplementation may represent a safe and effective nutritional intervention to restore Mg status without impairing the CTX efficacy.

Published
2020

32. Advancements towards the implementation of clinical phase-contrast breast computed tomography at Elettra

Author

Longo, R., Arfelli, F., Bonazza, D., Bottigli, U., Brombal, L., Cova, M.A., Delogu, P., Lillo, F. Di, Trapani, V., Donato, S. di, Dreossi, D., Fanti, V., Fedon, C., Golosio, B., Mettivier, G., Oliva, P., Pacile, S., Sarno, A., Rigon, L., Russo, P., Taibi, A., Tonutti, M., Zanconati, F., Tromba, G., Longo, R., Arfelli, F., Bonazza, D., Bottigli, U., Brombal, L., Cova, M.A., Delogu, P., Lillo, F. Di, Trapani, V., Donato, S. di, Dreossi, D., Fanti, V., Fedon, C., Golosio, B., Mettivier, G., Oliva, P., Pacile, S., Sarno, A., Rigon, L., Russo, P., Taibi, A., Tonutti, M., Zanconati, F., and Tromba, G.

Abstract

Item does not contain fulltext, Breast computed tomography (BCT) is an emerging application of X-ray tomography in radiological practice. A few clinical prototypes are under evaluation in hospitals and new systems are under development aiming at improving spatial and contrast resolution and reducing delivered dose. At the same time, synchrotron-radiation phase-contrast mammography has been demonstrated to offer substantial advantages when compared with conventional mammography. At Elettra, the Italian synchrotron radiation facility, a clinical program of phase-contrast BCT based on the free-space propagation approach is under development. In this paper, full-volume breast samples imaged with a beam energy of 32 keV delivering a mean glandular dose of 5 mGy are presented. The whole acquisition setup mimics a clinical study in order to evaluate its feasibility in terms of acquisition time and image quality. Acquisitions are performed using a high-resolution CdTe photon-counting detector and the projection data are processed via a phase-retrieval algorithm. Tomographic reconstructions are compared with conventional mammographic images acquired prior to surgery and with histologic examinations. Results indicate that BCT with monochromatic beam and free-space propagation phase-contrast imaging provide relevant three-dimensional insights of breast morphology at clinically acceptable doses and scan times.

Published
2019

33. Dysregulation of Mg2+ homeostasis contributes to acquisition of cancer hallmarks

Author

Trapani, Valentina, Wolf Minotti, Federica, Trapani V. (ORCID:0000-0002-0259-6624), Wolf F (ORCID:0000-0003-1361-1049), Trapani, Valentina, Wolf Minotti, Federica, Trapani V. (ORCID:0000-0002-0259-6624), and Wolf F (ORCID:0000-0003-1361-1049)

Abstract

Derangement of magnesium homeostasis underlies the pathophysiology of many diseases, including cancer. Recent advances support the view that aberrant expression of Mg2+ channels and other Mg2+ homeostatic factors may affect many hallmarks of cancer. The seminal idea of magnesium as a key regulator of cell proliferation has been enriched by novel intriguing findings that link magnesium and Mg2+ transporters to distinctive and complementary capabilities that enable tumour growth and metastatic dissemination. In this review, we examine the evidence on the involvement of members from the TRPM, CNNM and SCL41 protein families in cancer progression, and discuss their potential as therapeutic targets.

Published
2019

36. Oxidative Stress and Cardiovascular Risk in Type 1 Diabetes Mellitus: Insights From the DCCT/EDIC Study

Author

Tang, W.H. Wilson, primary, McGee, Paula, additional, Lachin, John M., additional, Li, Daniel Y., additional, Hoogwerf, Byron, additional, Hazen, Stanley L., additional, Nathan, D.M., additional, Zinman, B., additional, Crofford, O., additional, Genuth, S., additional, Brown‐Friday, J., additional, Crandall, J., additional, Engel, H., additional, Engel, S., additional, Martinez, H., additional, Phillips, M., additional, Reid, M., additional, Shamoon, H., additional, Sheindlin, J., additional, Gubitosi‐Klug, R., additional, Mayer, L., additional, Pendegast, S., additional, Zegarra, H., additional, Miller, D., additional, Singerman, L., additional, Smith‐Brewer, S., additional, Novak, M., additional, Quin, J., additional, Genuth, Saul, additional, Palmert, M., additional, Brown, E., additional, McConnell, J., additional, Pugsley, P., additional, Crawford, P., additional, Dahms, W., additional, Gregory, N.S., additional, Lackaye, M.E., additional, Kiss, S., additional, Chan, R., additional, Orlin, A., additional, Rubin, M., additional, Brillon, D., additional, Reppucci, V., additional, Lee, T., additional, Heinemann, M., additional, Chang, S., additional, Levy, B., additional, Jovanovic, L., additional, Richardson, M., additional, Bosco, B., additional, Dwoskin, A., additional, Hanna, R., additional, Barron, S., additional, Campbell, R., additional, Bhan, A., additional, Kruger, D., additional, Jones, J.K., additional, Edwards, P.A., additional, Carey, J.D., additional, Angus, E., additional, Thomas, A., additional, Galprin, A., additional, McLellan, M., additional, Whitehouse, F., additional, Bergenstal, R., additional, Johnson, M., additional, Gunyou, K., additional, Thomas, L., additional, Laechelt, J., additional, Hollander, P., additional, Spencer, M., additional, Kendall, D., additional, Cuddihy, R., additional, Callahan, P., additional, List, S., additional, Gott, J., additional, Rude, N., additional, Olson, B., additional, Franz, M., additional, Castle, G., additional, Birk, R., additional, Nelson, J., additional, Freking, D., additional, Gill, L., additional, Mestrezat, W., additional, Etzwiler, D., additional, Morgan, K., additional, Aiello, L.P., additional, Golden, E., additional, Arrigg, P., additional, Asuquo, V., additional, Beaser, R., additional, Bestourous, L., additional, Cavallerano, J., additional, Cavicchi, R., additional, Ganda, O., additional, Hamdy, O., additional, Kirby, R., additional, Murtha, T., additional, Schlossman, D, additional, Shah, S., additional, Sharuk, G., additional, Silva, P., additional, Silver, P., additional, Stockman, M., additional, Sun, J., additional, Weimann, E., additional, Wolpert, H., additional, Aiello, L.M., additional, Jacobson, A., additional, Rand, L., additional, Rosenzwieg, J., additional, Larkin, M.E., additional, Christofi, M., additional, Folino, K., additional, Godine, J., additional, Lou, P., additional, Stevens, C., additional, Anderson, E., additional, Bode, H., additional, Brink, S., additional, Cornish, C., additional, Cros, D., additional, Delahanty, L., additional, eManbey, ., additional, Haggan, C., additional, Lynch, J., additional, McKitrick, C., additional, Norman, D., additional, Moore, D., additional, Ong, M., additional, Taylor, C., additional, Zimbler, D., additional, Crowell, S., additional, Fritz, S., additional, Hansen, K., additional, Gauthier‐Kelly, C., additional, Service, F.J., additional, Ziegler, G., additional, Barkmeier, A., additional, Schmidt, L., additional, French, B., additional, Woodwick, R., additional, Rizza, R., additional, Schwenk, W.F., additional, Haymond, M., additional, Pach, J., additional, Mortenson, J., additional, Zimmerman, B., additional, Lucas, A., additional, Colligan, R., additional, Luttrell, L., additional, Lopes‐Virella, M., additional, Caulder, S., additional, Pittman, C., additional, Patel, N., additional, Lee, K., additional, Nutaitis, M., additional, Fernandes, J., additional, Hermayer, K., additional, Kwon, S., additional, Blevins, A, additional, Parker, J., additional, Colwell, J., additional, Lee, D., additional, Soule, J., additional, Lindsey, P., additional, Bracey, M., additional, Farr, A., additional, Elsing, S., additional, Thompson, T., additional, Selby, J., additional, Lyons, T., additional, Yacoub‐Wasef, S., additional, Szpiech, M., additional, Wood, D., additional, Mayfield, R., additional, Molitch, M., additional, Adelman, D., additional, Colson, S., additional, Jampol, L., additional, Lyon, A., additional, Gill, M., additional, Strugula, Z., additional, Kaminski, L., additional, Mirza, R., additional, Simjanoski, E., additional, Ryan, D., additional, Johnson, C., additional, Wallia, A., additional, Ajroud‐Driss, S., additional, Astelford, P., additional, Leloudes, N., additional, Degillio, A., additional, Schaefer, B., additional, Mudaliar, S., additional, Lorenzi, G, additional, Goldbaum, M., additional, Jones, K., additional, Prince, M., additional, Swenson, M., additional, Grant, I., additional, Reed, R., additional, Lyon, R., additional, Kolterman, O., additional, Giotta, M., additional, Clark, T., additional, Friedenberg, G., additional, Sivitz, W.I., additional, Vittetoe, B., additional, Kramer, J., additional, Bayless, M., additional, Zeitler, R., additional, Schrott, H., additional, Olson, N., additional, Snetselaar, L., additional, Hoffman, R., additional, MacIndoe, J., additional, Weingeist, T., additional, Fountain, C., additional, Miller, R., additional, Johnsonbaugh, S., additional, Patronas, M., additional, Carney, M., additional, Mendley, S., additional, Salemi, P., additional, Liss, R., additional, Hebdon, M., additional, Counts, D., additional, Donner, T., additional, Gordon, J., additional, Hemady, R., additional, Kowarski, A., additional, Ostrowski, D., additional, Steidl, S., additional, Jones, B., additional, Herman, W.H., additional, Martin, C.L., additional, Pop‐Busui, R., additional, Greene, D.A., additional, Stevens, M.J., additional, Burkhart, N., additional, Sandford, T., additional, Floyd, J., additional, Bantle, J., additional, Flaherty, N., additional, Terry, J., additional, Koozekanani, D., additional, Montezuma, S., additional, Wimmergren, N., additional, Rogness, B., additional, Mech, M., additional, Strand, T., additional, Olson, J., additional, McKenzie, L., additional, Kwong, C., additional, Goetz, F., additional, Warhol, R., additional, Hainsworth, D., additional, Goldstein, D., additional, Hitt, S., additional, Giangiacomo, J., additional, Schade, D.S, additional, Canady, J.L., additional, Burge, M.R., additional, Das, A., additional, Avery, R.B., additional, Ketai, L.H., additional, Chapin, J.E., additional, Schluter, M.L., additional, Rich, J., additional, Johannes, C., additional, Hornbeck, D., additional, Schutta, M., additional, Bourne, P.A., additional, Brucker, A., additional, Braunstein, S., additional, Schwartz, S., additional, Maschak‐Carey, B.J., additional, Baker, L., additional, Orchard, T., additional, Cimino, L., additional, Songer, T., additional, Doft, B., additional, Olson, S., additional, Becker, D., additional, Rubinstein, D., additional, Bergren, R.L., additional, Fruit, J., additional, Hyre, R., additional, Palmer, C., additional, Silvers, N., additional, Lobes, L., additional, Rath, P. Paczan, additional, Conrad, P.W., additional, Yalamanchi, S., additional, Wesche, J., additional, Bratkowksi, M., additional, Arslanian, S., additional, Rinkoff, J., additional, Warnicki, J., additional, Curtin, D., additional, Steinberg, D., additional, Vagstad, G., additional, Harris, R., additional, Steranchak, L., additional, Arch, J., additional, Kelly, K., additional, Ostrosaka, P., additional, Guiliani, M., additional, Good, M., additional, Williams, T., additional, Olsen, K., additional, Campbell, A., additional, Shipe, C., additional, Conwit, R., additional, Finegold, D., additional, Zaucha, M., additional, Drash, A., additional, Morrison, A., additional, Malone, J.I., additional, Bernal, M.L., additional, Pavan, P.R., additional, Grove, N., additional, Tanaka, E.A., additional, McMillan, D., additional, Vaccaro‐Kish, J., additional, Babbione, L., additional, Solc, H., additional, DeClue, T.J., additional, Dagogo‐Jack, S., additional, Wigley, C., additional, Ricks, H., additional, Kitabchi, A., additional, Chaum, E., additional, Murphy, M.B., additional, Moser, S., additional, Meyer, D., additional, Iannacone, A., additional, Yoser, S., additional, Bryer‐Ash, M., additional, Schussler, S., additional, Lambeth, H., additional, Raskin, P., additional, Strowig, S., additional, Basco, M., additional, Cercone, S., additional, Barnie, A., additional, Devenyi, R., additional, Mandelcorn, M., additional, Brent, M., additional, Rogers, S., additional, Gordon, A., additional, Bakshi, N., additional, Perkins, B., additional, Tuason, L., additional, Perdikaris, F., additional, Ehrlich, R., additional, Daneman, D., additional, Perlman, K., additional, Ferguson, S, additional, Palmer, J., additional, Fahlstrom, R., additional, de Boer, I.H., additional, Kinyoun, J., additional, Van Ottingham, L., additional, Catton, S., additional, Ginsberg, J., additional, McDonald, C., additional, Harth, J., additional, Driscoll, M., additional, Sheidow, T., additional, Mahon, J., additional, Canny, C., additional, Nicolle, D., additional, Colby, P., additional, Dupre, J., additional, Hramiak, I., additional, Rodger, N.W., additional, Jenner, M., additional, Smith, T., additional, Brown, W., additional, May, M., additional, Lipps Hagan, J., additional, Agarwal, A., additional, Adkins, T., additional, Lorenz, R., additional, Feman, S., additional, Survant, L., additional, White, N.H., additional, Levandoski, L., additional, Grand, G., additional, Thomas, M., additional, Joseph, D., additional, Blinder, K., additional, Shah, G., additional, Burgess, D., additional, Boniuk, I., additional, Santiago, J., additional, Tamborlane, W., additional, Gatcomb, P., additional, Stoessel, K., additional, Ramos, P., additional, Fong, K., additional, Ossorio, P., additional, Ahern, J., additional, Meadema‐Mayer, L., additional, Beck, C., additional, Farrell, K., additional, Quin, J, additional, Gaston, P., additional, Trail, R., additional, Lachin, J., additional, Backlund, J., additional, Bebu, I., additional, Braffett, B., additional, Diminick, L., additional, Gao, X., additional, Hsu, W., additional, Klumpp, K., additional, Pan, H., additional, Trapani, V., additional, Cleary, P., additional, McGee, P., additional, Sun, W., additional, Villavicencio, S., additional, Anderson, K., additional, Dews, L., additional, Younes, Naji, additional, Rutledge, B., additional, Chan, K., additional, Rosenberg, D., additional, Petty, B., additional, Determan, A., additional, Kenny, D., additional, Williams, C., additional, Cowie, C., additional, Siebert, C., additional, Steffes, M., additional, Arends, V., additional, Bucksa, J., additional, Nowicki, M., additional, Chavers, B., additional, O'Leary, D., additional, Polak, J., additional, Harrington, A., additional, Funk, L., additional, Crow, R, additional, Gloeb, B., additional, Thomas, S., additional, O'Donnell, C., additional, Soliman, E.Z., additional, Zhang, Z.M., additional, Li, Y., additional, Campbell, C., additional, Keasler, L., additional, Hensley, S., additional, Hu, J., additional, Barr, M., additional, Taylor, T., additional, Prineas, R., additional, Feldman, E.L., additional, Albers, J.W., additional, Low, P., additional, Sommer, C., additional, Nickander, K., additional, Speigelberg, T., additional, Pfiefer, M., additional, Schumer, M., additional, Moran, M., additional, Farquhar, J., additional, Ryan, C., additional, Sandstrom, D., additional, Geckle, M., additional, Cupelli, E., additional, Thoma, F., additional, Burzuk, B., additional, Woodfill, T., additional, Danis, R., additional, Blodi, B., additional, Lawrence, D., additional, Wabers, H., additional, Gangaputra, S., additional, Neill, S., additional, Burger, M., additional, Dingledine, J., additional, Gama, V., additional, Sussman, R., additional, Davis, M., additional, Hubbard, L., additional, Budoff, M., additional, Darabian, S., additional, Rezaeian, P., additional, Wong, N., additional, Fox, M., additional, Oudiz, R., additional, Kim, L, additional, Detrano, R., additional, Cruickshanks, K., additional, Dalton, D., additional, Bainbridge, K., additional, Lima, J., additional, Bluemke, D., additional, Turkbey, E., additional, der Geest, ., additional, Liu, C., additional, Malayeri, A., additional, Jain, A., additional, Miao, C., additional, Chahal, H., additional, Jarboe, R., additional, Monnier, V., additional, Sell, D., additional, Strauch, C., additional, Hazen, S., additional, Pratt, A., additional, Tang, W., additional, Brunzell, J., additional, Purnell, J., additional, Natarajan, R., additional, Miao, F., additional, Zhang, L., additional, Chen, Z., additional, Paterson, A., additional, Boright, A., additional, Bull, S., additional, Sun, L., additional, Scherer, S., additional, Lyons, T.J., additional, Jenkins, A., additional, Klein, R., additional, Virella, G., additional, Jaffa, A., additional, Carter, R., additional, Stoner, J., additional, Garvey, W.T., additional, Lackland, D., additional, Brabham, M., additional, McGee, D., additional, Zheng, D., additional, Mayfield, R.K., additional, Maynard, J., additional, Wessells, H., additional, Sarma, A, additional, Dunn, R., additional, Holt, S., additional, Hotaling, J., additional, Kim, C., additional, Clemens, Q., additional, Brown, J., additional, and McVary, K., additional

Published
2018
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37. Tumour development through the Mg2+fying glass

Author

Mudipalli, Anuradha, Zelikoff, Judith, Trapani, V (ORCID:0000-0002-0259-6624), Wolf, F (ORCID:0000-0003-1361-1049), Mudipalli, Anuradha, Zelikoff, Judith, Trapani, V (ORCID:0000-0002-0259-6624), and Wolf, F (ORCID:0000-0003-1361-1049)

Abstract

The last decades have witnessed a greater appreciation of the importance of magnesium for human health, but the relationship between magnesium and cancer development remains controversial. Here we review the current knowledge on the cellular and molecular mechanisms that underlie the manifold effects of magnesium during tumor progression. A complex picture emerges where the positive consequences of low magnesium availability on tumor growth seem to be counterbalanced by negative outcomes in the very early and late stages of tumorigenesis; a concurrent immune-inflammatory response appears to contribute throughout the natural history of a tumor. We also discuss the debated interaction between magnesium status and the response to therapy and the potential application of the TRPM7 magnesium channel as a prognostic marker and a therapeutic target. A deeper understanding of magnesium homeostasis through the interaction of fundamental and clinical researchers is key to develop new strategies of cancer prevention and treatment.

Published
2017

38. Tumor development through the Mg2+nifying glass

Author

A. Mudipalli, J. Zelikoff, Trapani, Valentina, Wolf Minotti, Federica, Trapani V. (ORCID:0000-0002-0259-6624), Wolf F. (ORCID:0000-0003-1361-1049), A. Mudipalli, J. Zelikoff, Trapani, Valentina, Wolf Minotti, Federica, Trapani V. (ORCID:0000-0002-0259-6624), and Wolf F. (ORCID:0000-0003-1361-1049)

Abstract

The last decades have witnessed a greater appreciation of the importance of magnesium for human health, but the relationship between magnesium and cancer development remains controversial. Here we review the current knowledge on the cellular and molecular mechanisms that underlie the manifold effects of magnesium during tumor progression. A complex picture emerges where the positive consequences of low magnesium availability on tumor growth seem to be counterbalanced by negative outcomes in the very early and late stages of tumorigenesis; a concurrent immune-inflammatory response appears to contribute throughout the natural history of a tumor. We also discuss the debated interaction between magnesium status and the response to therapy and the potential application of the TRPM7 magnesium channel as a prognostic marker and a therapeutic target. A deeper understanding of magnesium homeostasis through the interaction of fundamental and clinical researchers is key to develop new strategies of cancer prevention and treatment.

Published
2017

39. Magnesium deficiency and endothelial dysfunction: is oxidative stress involved?

Author

Wolf, F.I., Trapani, V., Simonacci, M., Ferre, S., and Maier, J.A.

Subjects
Renal disorders [UMCN 5.4], Metabolism, transport and motion [NCMLS 2]
Abstract

Contains fulltext : 69110.pdf (Publisher’s version ) (Closed access) Low magnesium (Mg) has been associated with oxidative stress, an important player in aging, atherosclerosis and other vascular diseases. In vivo, low Mg and immune system activation seem to cooperate to promote endothelial dysfunction. We therefore evaluated whether exposure of human endothelial cells to low Mg in vitro determines oxidative stress features. We therefore measured intracellular reactive oxygen species (ROS) by dichlorofluorescein (DCF) fluorescence after Mg deprivation with or without treatment with H2O2 While we did not observe any alteration of DCF-detectable intracellular ROS under basal conditions, we show that, early after exposure to low Mg (2 h), endothelial cells are more sensitive to the oxidant action of H2O2 than the controls cultured in physiologic concentrations of Mg. This increase of ROS in Mg deprived cells is transient and followed by a stable reduction of DCF-fluorescence below the levels measured in the controls. We also evaluated oxidative DNA damage and observed higher 8-hydroxy-deoxyguanine levels early (2 h) after Mg deprivation in respect to the controls, both in basal conditions and after treatment with H2O2 Mg deficiency in vivo associates with the onset of an inflammatory response leading to increased circulating levels of cytokines, which trigger an oxidative response in endothelial cells. We here show that exposure to IL-1 and IL-6 significantly increased the levels of DCF-detectable ROS in cells cultured in physiologic concentrations of Mg, but not in Mg-deprived cells. We conclude that low Mg transiently leads to pro-oxidant effects. We suggest that different molecules, including pro-inflammatory cytokines, might be involved in promoting endothelial dysfunction.

Published
2008

41. maculopatia associata a tilted disk

Author

Sunseri Trapani, V., Maria VADALA', Alfano, A., Giuseppe Giuffrè, Cillino, Salvatore, Sunseri Trapani, V, Vadala', M, Alfano, A, Giuffre', G, and Cillino, S

Subjects
tilted disk, patologie maculari, maculopatia, Settore MED/30 - Malattie Apparato Visivo
Published
2013

43. Retroperitoneal schwannoma unusually presenting as severe constipation

Author

Fei, L., Trapani, V., Moccia, F., Rosa, G., Chiara Mignogna, Cimmino, M., Galloro, G., Abbadessa, A., Landino, Fei, Vincenzo, Trapani, Francesco, Moccia, DE ROSA, Gaetano, Chiara, Mignogna, Marco, Cimmino, Galloro, Giuseppe, Antonio, Abbadessa, Fei, Landino, Trapani, V, Moccia, F, De Rosa, G, Mignogna, C, Cimmino, M, Galloro, G, and Abbadessa, A.

Subjects
Radiography, Abdominal, Time Factors, Treatment Outcome, Humans, Female, Retroperitoneal Neoplasms, Middle Aged, Tomography, X-Ray Computed, Constipation, Immunohistochemistry, Neurilemmoma, Follow-Up Studies
Abstract

Retroperitoneal schwannomas are rare tumours originating from Schwann cells of peripheral nerve sheaths. Their clinical presentation is often delayed as they grow to a large size in a non-restrictive space, such as the retroperitoneum, before any clear symptomatology is manifested. Furthermore, the symptoms may mimic different diseases and be aspecific. The preoperative diagnosis is often unclear as no pathognomonic radiological features are known. Fine needle biopsy is not diagnostic due to tumour cell pleomorphism. We report the case of a 51-year-old woman presenting with unusual symptoms such as severe constipation, bowel distension, excess flatus, postprandial fullness and abdominal pain due to left colon compression by a large retroperitoneal tumour. A complete resection of the mass combined with sparing of the surrounding tissues was carried out through a midline laparotomy. Microscopic evaluation and immunohistochemistry documented a benign retroperitoneal schwannoma. Postoperatively, complete resolution of abdominal symptoms and no major complications were observed. At 28 months' follow-up no local recurrence was found. To the best of our knowledge, this is a rare case of retroperitoneal schwannoma with definite abdominal symptoms and with sudden onset of severe constipation.

Published
2009

44. A rare case of left diaphragmatic agenesis in an elderly patient

Author

Landino FEI, Trapani, V., Moccia, F., Cimmino, M., Fei, Landino, Trapani, V, Moccia, F, and Cimmino, M.

Subjects
Male, Diaphragm, Humans, Polytetrafluoroethylene, Aged
Abstract

A 71-year-old man affected by left hemidiaphragmatic agenesis developed late severe constipation and occasional episodes of bowel obstruction. At left subcostal laparotomy, the stomach, transverse colon, splenic flexure, and spleen were located in the left hemithorax. Repair was performed with a 2-mm-thick expanded polytetrafluoroethylene (Gore-Tex) patch secured in place circumferentially as a new diaphragmatic dome. No early major complications and no recurrence at 34 months' follow-up were observed. To the best of our knowledge, this is the oldest treated patient with a true hemidiaphragmatic agenesis and is the eighth case reported in the literature. The use of the ePTFE soft tissue patch, thanks to its strength and pliability, affords good anatomical and functional repair.

Published
2008

45. THE SHORT ESOPHAGUS: INTRAOPEARATIVE ASSESSMENT OF ESOPHAGEAL LENGTH

Author

MATTIOLI, SANDRO, LUGARESI, MARIALUISA, Costantini M., Del Genio A., Di Martino N., Fei L., Fumagalli U., Maffettone V., Monaco L., Morino M., Rebecchi F., Rosati R., Rossi M., Santi S., Trapani V., Zaninotto G., Mattioli S., Lugaresi M.L., Costantini M., Del Genio A., Di Martino N., Fei L., Fumagalli U., Maffettone V., Monaco L., Morino M., Rebecchi F., Rosati R., Rossi M., Santi S., Trapani V., and Zaninotto G.

Subjects
CHIRURGIA, MALATTIA DA REFLUSSO GASTRO-ESOFAGEO, ESOFAGO, TORACE, digestive system diseases, BRACHIESOFAGO
Abstract

OBJECTIVE: To define the frequency and predictors of short esophagus in a case series of patients undergoing antireflux surgery. METHOD: An observational prospective study from September 10, 2004, to October 31, 2006, was performed at 8 centers. The distance between the esophagogastric junction as identified by intraoperative esophagoscopy and the apex of the diaphragmatic hiatus was measured intraoperatively before and after esophageal mediastinal dissection; a distance of 1.5 cm was arbitrarily determined to categorize cases as long (>1.5 cm) or short (

Published
2008

46. Stenosi, perforazioni e sindromi rare

Author

FEI, Landino, Trapani V, Cimmino M., Bellantone R, De Toma G, Montorsi M, Bellantone R, de Toma G, Montorsi M, Fei, Landino, Trapani, V, and Cimmino, M.

Published
2008

49. Magnesium: a new player in the apoptotic signalling cascade?

Author

Trapani V., Boninsegna A., Simonacci M., Savage P. B, Wolf FI ., FARRUGGIA, GIOVANNA, IOTTI, STEFANO, PRODI, LUCA, Trapani V., Farruggia G., Iotti S., Prodi L., Boninsegna A., Simonacci M., Savage P.B, and Wolf FI .

Published
2006

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