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2. Clinician acceptability of the ReacStep reactive balance training program for fall prevention.

Author

Ho, Chrissie, Sharma, Shivam, Huang, Tiffany, Cheung, Daniel, Hicks, Cameron, Treacy, Daniel, Farlie, Melanie K., Lam, Freddy M. H., Lord, Stephen R., and Okubo, Yoshiro

Subjects
STATISTICAL power analysis, THERAPEUTICS, HUMAN services programs, T-test (Statistics), PATIENT safety, SELF-efficacy, PATIENTS, CONTENT analysis, QUESTIONNAIRES, DESCRIPTIVE statistics, ANXIETY, MOBILITY training, SURVEYS, EXERCISE physiologists, ATTITUDES of medical personnel, CONFIDENCE intervals, DATA analysis software, ACCIDENTAL falls, POSTURAL balance, MEDICAL practice
Abstract

Aim: To examine if a novel reactive balance training program (ReacStep) designed for clinical settings is acceptable to clinicians prescribing balance and mobility training. Methods: ReacStep consists of tether‐release reactive step training, volitional trip and slip training, and functional strength training. An open survey comprising 11‐point visual analog scale items (0 = strongly disagree to 10 = strongly agree) based on the Theoretical Framework of Acceptability was sent to clinicians working in balance and mobility training. Items evaluated the acceptability of ReacStep across seven domains (intervention coherence, perceived efficacy, self‐efficacy, ethicality, affective attitude, burden and opportunity cost). Results: Two hundred and seven clinicians (169 Physiotherapists, 22 Exercise Physiologists, 11 Occupational Therapists and five others) completed the survey. Respondents considered ReacStep to have good overall acceptability, intervention coherence, effectiveness, ethicality and self‐efficacy (mean acceptability scores >7). However, respondent's ratings of ReacStep's affective attitude, burden and opportunity cost were more variable (mean acceptability scores 2–8) due to concerns about client anxiety, the need for a safety harness and staffing and training requirements. Respondents considered that ReacStep would be more effective and safer to conduct in geriatrics clients compared with neurological clients, and that it would be more appropriate for rehabilitation and private practice settings compared to home settings. Conclusions: ReacStep was generally acceptable from the perspective of clinicians who prescribe balance and mobility training in various clinical settings, and was deemed more effective and safer for older clients without neurological conditions, and beneficial in outpatient rehabilitation and private practice settings. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Planning implementation and scale-up of physical activity interventions for people with walking difficulties: study protocol for the process evaluation of the ComeBACK trial

Author

Wong, Siobhan, Hassett, Leanne, Koorts, Harriet, Grunseit, Anne, Tong, Allison, Tiedemann, Anne, Greaves, Colin J., Haynes, Abby, Milat, Andrew, Harvey, Lisa A., Taylor, Nicholas F., Hinman, Rana S., Pinherio, Marina De Barros, Jennings, Matthew, Treacy, Daniel, O’Rourke, Sandra, West, Courtney, Ramsay, Elizabeth, Kirkham, Catherine, Morris, Claire, and Sherrington, Catherine

Published
2022
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6. Assigning clinical meaning to somatic and germ-line whole-exome sequencing data in a prospective cancer precision medicine study

Author

Ghazani, Arezou A., Oliver, Nelly M., St. Pierre, Joseph P., Garofalo, Andrea, Rainville, Irene R., Hiller, Elaine, Treacy, Daniel J., Rojas-Rudilla, Vanesa, Wood, Sam, Bair, Elizabeth, Parello, Michael, Huang, Franklin, Giannakis, Marios, Wilson, Frederick H., Stover, Elizabeth H., Corsello, Steven M., Nguyen, Tom, Rana, Huma Q., Church, Alanna J., Lowenstein, Carol, Cibulskis, Carrie, Amin-Mansour, Ali, Heng, Jennifer, Brais, Lauren, Santos, Abigail, Bauer, Patrick, Waldron, Amanda, Lo, Peter, Gorman, Megan, Lydon, Christine A., Welch, Marisa, McNamara, Philip, Gabriel, Stacey, Sholl, Lynette M., Lindeman, Neal I., Garber, Judy E., Joffe, Steven, Van Allen, Eliezer M., Gray, Stacy W., Jänne, Pasi A., Garraway, Levi A., and Wagle, Nikhil

Published
2017
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7. Data from MAP Kinase Pathway Alterations in BRAF-Mutant Melanoma Patients with Acquired Resistance to Combined RAF/MEK Inhibition

Author

Wagle, Nikhil, primary, Van Allen, Eliezer M., primary, Treacy, Daniel J., primary, Frederick, Dennie T., primary, Cooper, Zachary A., primary, Taylor-Weiner, Amaro, primary, Rosenberg, Mara, primary, Goetz, Eva M., primary, Sullivan, Ryan J., primary, Farlow, Deborah N., primary, Friedrich, Dennis C., primary, Anderka, Kristin, primary, Perrin, Danielle, primary, Johannessen, Cory M., primary, McKenna, Aaron, primary, Cibulskis, Kristian, primary, Kryukov, Gregory, primary, Hodis, Eran, primary, Lawrence, Donald P., primary, Fisher, Sheila, primary, Getz, Gad, primary, Gabriel, Stacey B., primary, Carter, Scott L., primary, Flaherty, Keith T., primary, Wargo, Jennifer A., primary, and Garraway, Levi A., primary

Published
2023
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9. Supplementary Table 3 from MAP Kinase Pathway Alterations in BRAF-Mutant Melanoma Patients with Acquired Resistance to Combined RAF/MEK Inhibition

Author

Wagle, Nikhil, primary, Van Allen, Eliezer M., primary, Treacy, Daniel J., primary, Frederick, Dennie T., primary, Cooper, Zachary A., primary, Taylor-Weiner, Amaro, primary, Rosenberg, Mara, primary, Goetz, Eva M., primary, Sullivan, Ryan J., primary, Farlow, Deborah N., primary, Friedrich, Dennis C., primary, Anderka, Kristin, primary, Perrin, Danielle, primary, Johannessen, Cory M., primary, McKenna, Aaron, primary, Cibulskis, Kristian, primary, Kryukov, Gregory, primary, Hodis, Eran, primary, Lawrence, Donald P., primary, Fisher, Sheila, primary, Getz, Gad, primary, Gabriel, Stacey B., primary, Carter, Scott L., primary, Flaherty, Keith T., primary, Wargo, Jennifer A., primary, and Garraway, Levi A., primary

Published
2023
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11. Supplementary Table 2 from MAP Kinase Pathway Alterations in BRAF-Mutant Melanoma Patients with Acquired Resistance to Combined RAF/MEK Inhibition

Author

Wagle, Nikhil, primary, Van Allen, Eliezer M., primary, Treacy, Daniel J., primary, Frederick, Dennie T., primary, Cooper, Zachary A., primary, Taylor-Weiner, Amaro, primary, Rosenberg, Mara, primary, Goetz, Eva M., primary, Sullivan, Ryan J., primary, Farlow, Deborah N., primary, Friedrich, Dennis C., primary, Anderka, Kristin, primary, Perrin, Danielle, primary, Johannessen, Cory M., primary, McKenna, Aaron, primary, Cibulskis, Kristian, primary, Kryukov, Gregory, primary, Hodis, Eran, primary, Lawrence, Donald P., primary, Fisher, Sheila, primary, Getz, Gad, primary, Gabriel, Stacey B., primary, Carter, Scott L., primary, Flaherty, Keith T., primary, Wargo, Jennifer A., primary, and Garraway, Levi A., primary

Published
2023
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12. Data from The Genetic Landscape of Clinical Resistance to RAF Inhibition in Metastatic Melanoma

Author

Van Allen, Eliezer M., primary, Wagle, Nikhil, primary, Sucker, Antje, primary, Treacy, Daniel J., primary, Johannessen, Cory M., primary, Goetz, Eva M., primary, Place, Chelsea S., primary, Taylor-Weiner, Amaro, primary, Whittaker, Steven, primary, Kryukov, Gregory V., primary, Hodis, Eran, primary, Rosenberg, Mara, primary, McKenna, Aaron, primary, Cibulskis, Kristian, primary, Farlow, Deborah, primary, Zimmer, Lisa, primary, Hillen, Uwe, primary, Gutzmer, Ralf, primary, Goldinger, Simone M., primary, Ugurel, Selma, primary, Gogas, Helen J., primary, Egberts, Friederike, primary, Berking, Carola, primary, Trefzer, Uwe, primary, Loquai, Carmen, primary, Weide, Benjamin, primary, Hassel, Jessica C., primary, Gabriel, Stacey B., primary, Carter, Scott L., primary, Getz, Gad, primary, Garraway, Levi A., primary, and Schadendorf, Dirk, primary

Published
2023
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13. Supplementary Table S2 from The Genetic Landscape of Clinical Resistance to RAF Inhibition in Metastatic Melanoma

Author

Van Allen, Eliezer M., primary, Wagle, Nikhil, primary, Sucker, Antje, primary, Treacy, Daniel J., primary, Johannessen, Cory M., primary, Goetz, Eva M., primary, Place, Chelsea S., primary, Taylor-Weiner, Amaro, primary, Whittaker, Steven, primary, Kryukov, Gregory V., primary, Hodis, Eran, primary, Rosenberg, Mara, primary, McKenna, Aaron, primary, Cibulskis, Kristian, primary, Farlow, Deborah, primary, Zimmer, Lisa, primary, Hillen, Uwe, primary, Gutzmer, Ralf, primary, Goldinger, Simone M., primary, Ugurel, Selma, primary, Gogas, Helen J., primary, Egberts, Friederike, primary, Berking, Carola, primary, Trefzer, Uwe, primary, Loquai, Carmen, primary, Weide, Benjamin, primary, Hassel, Jessica C., primary, Gabriel, Stacey B., primary, Carter, Scott L., primary, Getz, Gad, primary, Garraway, Levi A., primary, and Schadendorf, Dirk, primary

Published
2023
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14. Supplementary Table 4 from MAP Kinase Pathway Alterations in BRAF-Mutant Melanoma Patients with Acquired Resistance to Combined RAF/MEK Inhibition

Author

Wagle, Nikhil, primary, Van Allen, Eliezer M., primary, Treacy, Daniel J., primary, Frederick, Dennie T., primary, Cooper, Zachary A., primary, Taylor-Weiner, Amaro, primary, Rosenberg, Mara, primary, Goetz, Eva M., primary, Sullivan, Ryan J., primary, Farlow, Deborah N., primary, Friedrich, Dennis C., primary, Anderka, Kristin, primary, Perrin, Danielle, primary, Johannessen, Cory M., primary, McKenna, Aaron, primary, Cibulskis, Kristian, primary, Kryukov, Gregory, primary, Hodis, Eran, primary, Lawrence, Donald P., primary, Fisher, Sheila, primary, Getz, Gad, primary, Gabriel, Stacey B., primary, Carter, Scott L., primary, Flaherty, Keith T., primary, Wargo, Jennifer A., primary, and Garraway, Levi A., primary

Published
2023
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15. Supplementary Table 1 from MAP Kinase Pathway Alterations in BRAF-Mutant Melanoma Patients with Acquired Resistance to Combined RAF/MEK Inhibition

Author

Wagle, Nikhil, primary, Van Allen, Eliezer M., primary, Treacy, Daniel J., primary, Frederick, Dennie T., primary, Cooper, Zachary A., primary, Taylor-Weiner, Amaro, primary, Rosenberg, Mara, primary, Goetz, Eva M., primary, Sullivan, Ryan J., primary, Farlow, Deborah N., primary, Friedrich, Dennis C., primary, Anderka, Kristin, primary, Perrin, Danielle, primary, Johannessen, Cory M., primary, McKenna, Aaron, primary, Cibulskis, Kristian, primary, Kryukov, Gregory, primary, Hodis, Eran, primary, Lawrence, Donald P., primary, Fisher, Sheila, primary, Getz, Gad, primary, Gabriel, Stacey B., primary, Carter, Scott L., primary, Flaherty, Keith T., primary, Wargo, Jennifer A., primary, and Garraway, Levi A., primary

Published
2023
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16. Supplementary Table 6 from MAP Kinase Pathway Alterations in BRAF-Mutant Melanoma Patients with Acquired Resistance to Combined RAF/MEK Inhibition

Author

Wagle, Nikhil, primary, Van Allen, Eliezer M., primary, Treacy, Daniel J., primary, Frederick, Dennie T., primary, Cooper, Zachary A., primary, Taylor-Weiner, Amaro, primary, Rosenberg, Mara, primary, Goetz, Eva M., primary, Sullivan, Ryan J., primary, Farlow, Deborah N., primary, Friedrich, Dennis C., primary, Anderka, Kristin, primary, Perrin, Danielle, primary, Johannessen, Cory M., primary, McKenna, Aaron, primary, Cibulskis, Kristian, primary, Kryukov, Gregory, primary, Hodis, Eran, primary, Lawrence, Donald P., primary, Fisher, Sheila, primary, Getz, Gad, primary, Gabriel, Stacey B., primary, Carter, Scott L., primary, Flaherty, Keith T., primary, Wargo, Jennifer A., primary, and Garraway, Levi A., primary

Published
2023
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17. Supplementary Figures from MAP Kinase Pathway Alterations in BRAF-Mutant Melanoma Patients with Acquired Resistance to Combined RAF/MEK Inhibition

Author

Wagle, Nikhil, primary, Van Allen, Eliezer M., primary, Treacy, Daniel J., primary, Frederick, Dennie T., primary, Cooper, Zachary A., primary, Taylor-Weiner, Amaro, primary, Rosenberg, Mara, primary, Goetz, Eva M., primary, Sullivan, Ryan J., primary, Farlow, Deborah N., primary, Friedrich, Dennis C., primary, Anderka, Kristin, primary, Perrin, Danielle, primary, Johannessen, Cory M., primary, McKenna, Aaron, primary, Cibulskis, Kristian, primary, Kryukov, Gregory, primary, Hodis, Eran, primary, Lawrence, Donald P., primary, Fisher, Sheila, primary, Getz, Gad, primary, Gabriel, Stacey B., primary, Carter, Scott L., primary, Flaherty, Keith T., primary, Wargo, Jennifer A., primary, and Garraway, Levi A., primary

Published
2023
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18. Supplementary Table Legends from The Genetic Landscape of Clinical Resistance to RAF Inhibition in Metastatic Melanoma

Author

Van Allen, Eliezer M., primary, Wagle, Nikhil, primary, Sucker, Antje, primary, Treacy, Daniel J., primary, Johannessen, Cory M., primary, Goetz, Eva M., primary, Place, Chelsea S., primary, Taylor-Weiner, Amaro, primary, Whittaker, Steven, primary, Kryukov, Gregory V., primary, Hodis, Eran, primary, Rosenberg, Mara, primary, McKenna, Aaron, primary, Cibulskis, Kristian, primary, Farlow, Deborah, primary, Zimmer, Lisa, primary, Hillen, Uwe, primary, Gutzmer, Ralf, primary, Goldinger, Simone M., primary, Ugurel, Selma, primary, Gogas, Helen J., primary, Egberts, Friederike, primary, Berking, Carola, primary, Trefzer, Uwe, primary, Loquai, Carmen, primary, Weide, Benjamin, primary, Hassel, Jessica C., primary, Gabriel, Stacey B., primary, Carter, Scott L., primary, Getz, Gad, primary, Garraway, Levi A., primary, and Schadendorf, Dirk, primary

Published
2023
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19. Data Supplement from MAP Kinase Pathway Alterations in BRAF-Mutant Melanoma Patients with Acquired Resistance to Combined RAF/MEK Inhibition

Author

Wagle, Nikhil, primary, Van Allen, Eliezer M., primary, Treacy, Daniel J., primary, Frederick, Dennie T., primary, Cooper, Zachary A., primary, Taylor-Weiner, Amaro, primary, Rosenberg, Mara, primary, Goetz, Eva M., primary, Sullivan, Ryan J., primary, Farlow, Deborah N., primary, Friedrich, Dennis C., primary, Anderka, Kristin, primary, Perrin, Danielle, primary, Johannessen, Cory M., primary, McKenna, Aaron, primary, Cibulskis, Kristian, primary, Kryukov, Gregory, primary, Hodis, Eran, primary, Lawrence, Donald P., primary, Fisher, Sheila, primary, Getz, Gad, primary, Gabriel, Stacey B., primary, Carter, Scott L., primary, Flaherty, Keith T., primary, Wargo, Jennifer A., primary, and Garraway, Levi A., primary

Published
2023
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20. Supplementary Table 5 from MAP Kinase Pathway Alterations in BRAF-Mutant Melanoma Patients with Acquired Resistance to Combined RAF/MEK Inhibition

Author

Wagle, Nikhil, primary, Van Allen, Eliezer M., primary, Treacy, Daniel J., primary, Frederick, Dennie T., primary, Cooper, Zachary A., primary, Taylor-Weiner, Amaro, primary, Rosenberg, Mara, primary, Goetz, Eva M., primary, Sullivan, Ryan J., primary, Farlow, Deborah N., primary, Friedrich, Dennis C., primary, Anderka, Kristin, primary, Perrin, Danielle, primary, Johannessen, Cory M., primary, McKenna, Aaron, primary, Cibulskis, Kristian, primary, Kryukov, Gregory, primary, Hodis, Eran, primary, Lawrence, Donald P., primary, Fisher, Sheila, primary, Getz, Gad, primary, Gabriel, Stacey B., primary, Carter, Scott L., primary, Flaherty, Keith T., primary, Wargo, Jennifer A., primary, and Garraway, Levi A., primary

Published
2023
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21. Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

Author

Tirosh, Itay, Izar, Benjamin, Prakadan, Sanjay M., Wadsworth, Marc H., Treacy, Daniel, Trombetta, John J., Rotem, Asaf, Rodman, Christopher, Lian, Christine, Murphy, George, Fallahi-Sichani, Mohammad, Dutton-Regester, Ken, Lin, Jia-Ren, Cohen, Ofir, Shah, Parin, Lu, Diana, Genshaft, Alex S., Hughes, Travis K., Ziegler, Carly G. K., Kazer, Samuel W., Gaillard, Aleth, Kolb, Kellie E., Villani, Alexandra-Chloé, Johannessen, Cory M., Andreev, Aleksandr Y., Van Allen, Eliezer M., Bertagnolli, Monica, Sorger, Peter K., Sullivan, Ryan J., Flaherty, Keith T., Frederick, Dennie T., Jané-Valbuena, Judit, Yoon, Charles H., Rozenblatt-Rosen, Orit, Shalek, Alex K., Regev, Aviv, and Garraway, Levi A.

Published
2016

22. Supplementary Table 3 from PLZF, a Tumor Suppressor Genetically Lost in Metastatic Castration-Resistant Prostate Cancer, Is a Mediator of Resistance to Androgen Deprivation Therapy

Author

Hsieh, Chen-Lin, primary, Botta, Ginevra, primary, Gao, Shuai, primary, Li, Tiantian, primary, Van Allen, Eliezer M., primary, Treacy, Daniel J., primary, Cai, Changmeng, primary, He, Housheng Hansen, primary, Sweeney, Christopher J., primary, Brown, Myles, primary, Balk, Steven P., primary, Nelson, Peter S., primary, Garraway, Levi A., primary, and Kantoff, Philip W., primary

Published
2023
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24. Suppl Figure 3 from PLZF, a Tumor Suppressor Genetically Lost in Metastatic Castration-Resistant Prostate Cancer, Is a Mediator of Resistance to Androgen Deprivation Therapy

Author

Hsieh, Chen-Lin, primary, Botta, Ginevra, primary, Gao, Shuai, primary, Li, Tiantian, primary, Van Allen, Eliezer M., primary, Treacy, Daniel J., primary, Cai, Changmeng, primary, He, Housheng Hansen, primary, Sweeney, Christopher J., primary, Brown, Myles, primary, Balk, Steven P., primary, Nelson, Peter S., primary, Garraway, Levi A., primary, and Kantoff, Philip W., primary

Published
2023
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25. Data from PLZF, a Tumor Suppressor Genetically Lost in Metastatic Castration-Resistant Prostate Cancer, Is a Mediator of Resistance to Androgen Deprivation Therapy

Author

Hsieh, Chen-Lin, primary, Botta, Ginevra, primary, Gao, Shuai, primary, Li, Tiantian, primary, Van Allen, Eliezer M., primary, Treacy, Daniel J., primary, Cai, Changmeng, primary, He, Housheng Hansen, primary, Sweeney, Christopher J., primary, Brown, Myles, primary, Balk, Steven P., primary, Nelson, Peter S., primary, Garraway, Levi A., primary, and Kantoff, Philip W., primary

Published
2023
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26. Suppl Figure 4 from PLZF, a Tumor Suppressor Genetically Lost in Metastatic Castration-Resistant Prostate Cancer, Is a Mediator of Resistance to Androgen Deprivation Therapy

Author

Hsieh, Chen-Lin, primary, Botta, Ginevra, primary, Gao, Shuai, primary, Li, Tiantian, primary, Van Allen, Eliezer M., primary, Treacy, Daniel J., primary, Cai, Changmeng, primary, He, Housheng Hansen, primary, Sweeney, Christopher J., primary, Brown, Myles, primary, Balk, Steven P., primary, Nelson, Peter S., primary, Garraway, Levi A., primary, and Kantoff, Philip W., primary

Published
2023
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27. Supplementary Table 1 from PLZF, a Tumor Suppressor Genetically Lost in Metastatic Castration-Resistant Prostate Cancer, Is a Mediator of Resistance to Androgen Deprivation Therapy

Author

Hsieh, Chen-Lin, primary, Botta, Ginevra, primary, Gao, Shuai, primary, Li, Tiantian, primary, Van Allen, Eliezer M., primary, Treacy, Daniel J., primary, Cai, Changmeng, primary, He, Housheng Hansen, primary, Sweeney, Christopher J., primary, Brown, Myles, primary, Balk, Steven P., primary, Nelson, Peter S., primary, Garraway, Levi A., primary, and Kantoff, Philip W., primary

Published
2023
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29. Supplementary Information from PLZF, a Tumor Suppressor Genetically Lost in Metastatic Castration-Resistant Prostate Cancer, Is a Mediator of Resistance to Androgen Deprivation Therapy

Author

Hsieh, Chen-Lin, primary, Botta, Ginevra, primary, Gao, Shuai, primary, Li, Tiantian, primary, Van Allen, Eliezer M., primary, Treacy, Daniel J., primary, Cai, Changmeng, primary, He, Housheng Hansen, primary, Sweeney, Christopher J., primary, Brown, Myles, primary, Balk, Steven P., primary, Nelson, Peter S., primary, Garraway, Levi A., primary, and Kantoff, Philip W., primary

Published
2023
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30. Suppl Figure 1 from PLZF, a Tumor Suppressor Genetically Lost in Metastatic Castration-Resistant Prostate Cancer, Is a Mediator of Resistance to Androgen Deprivation Therapy

Author

Hsieh, Chen-Lin, primary, Botta, Ginevra, primary, Gao, Shuai, primary, Li, Tiantian, primary, Van Allen, Eliezer M., primary, Treacy, Daniel J., primary, Cai, Changmeng, primary, He, Housheng Hansen, primary, Sweeney, Christopher J., primary, Brown, Myles, primary, Balk, Steven P., primary, Nelson, Peter S., primary, Garraway, Levi A., primary, and Kantoff, Philip W., primary

Published
2023
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31. Supplementary Table 2 from PLZF, a Tumor Suppressor Genetically Lost in Metastatic Castration-Resistant Prostate Cancer, Is a Mediator of Resistance to Androgen Deprivation Therapy

Author

Hsieh, Chen-Lin, primary, Botta, Ginevra, primary, Gao, Shuai, primary, Li, Tiantian, primary, Van Allen, Eliezer M., primary, Treacy, Daniel J., primary, Cai, Changmeng, primary, He, Housheng Hansen, primary, Sweeney, Christopher J., primary, Brown, Myles, primary, Balk, Steven P., primary, Nelson, Peter S., primary, Garraway, Levi A., primary, and Kantoff, Philip W., primary

Published
2023
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32. Suppl Figure 2 from PLZF, a Tumor Suppressor Genetically Lost in Metastatic Castration-Resistant Prostate Cancer, Is a Mediator of Resistance to Androgen Deprivation Therapy

Author

Hsieh, Chen-Lin, primary, Botta, Ginevra, primary, Gao, Shuai, primary, Li, Tiantian, primary, Van Allen, Eliezer M., primary, Treacy, Daniel J., primary, Cai, Changmeng, primary, He, Housheng Hansen, primary, Sweeney, Christopher J., primary, Brown, Myles, primary, Balk, Steven P., primary, Nelson, Peter S., primary, Garraway, Levi A., primary, and Kantoff, Philip W., primary

Published
2023
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36. Additional file 2 of Implementing digital devices to increase mobility training for people receiving inpatient rehabilitation: protocol for a feasibility hybrid type II randomized controlled trial

Author

Aravind, Nisha, Treacy, Daniel, Chagpar, Sakina, Harvey, Lisa A., Glinsky, Joanne V., Sherrington, Catherine, and Hassett, Leanne M.

Abstract

Additional file 2. Intervention protocol. Document guiding decision of digital device selection for intervention.

Published
2023
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37. Additional file 4 of Implementing digital devices to increase mobility training for people receiving inpatient rehabilitation: protocol for a feasibility hybrid type II randomized controlled trial

Author

Aravind, Nisha, Treacy, Daniel, Chagpar, Sakina, Harvey, Lisa A., Glinsky, Joanne V., Sherrington, Catherine, and Hassett, Leanne M.

Abstract

Additional file 4.Therapist-participant questionnaire to explore determinants of implementation success. Questionnaire used to capture the physiotherapists change in capability, opportunity, and motivation to prescribing and delivering rehabilitation using digital devices, developed based upon the COM-B self-evaluation questionnaire.

Published
2023
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38. Additional file 3 of Implementing digital devices to increase mobility training for people receiving inpatient rehabilitation: protocol for a feasibility hybrid type II randomized controlled trial

Author

Aravind, Nisha, Treacy, Daniel, Chagpar, Sakina, Harvey, Lisa A., Glinsky, Joanne V., Sherrington, Catherine, and Hassett, Leanne M.

Abstract

Additional file 3. Description of digital devices used in the trial for intervention participants. Name of digital devices used and their description. participants.

Published
2023
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39. Economic evaluation of digitally enabled aged and neurological rehabilitation care in the Activity and MObility UsiNg Technology (AMOUNT) trial

Author

Pinheiro, Marina B, primary, Hassett, Leanne, additional, Sherrington, Catherine, additional, Hayes, Alison, additional, van den Berg, Maayken, additional, Lindley, Richard I, additional, Crotty, Maria, additional, Chagpar, Sakina, additional, Treacy, Daniel, additional, Weber, Heather, additional, Fairhall, Nicola, additional, Wong, Siobhan, additional, McCluskey, Annie, additional, Togher, Leanne, additional, Scrivener, Katharine, additional, and Howard, Kirsten, additional

Published
2022
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40. Validity of different activity monitors to count steps in an inpatient rehabilitation setting

Author

Treacy, Daniel, Hassett, Leanne, Schurr, Karl, Chagpar, Sakina, Paul, Serene S., and Sherrington, Catherine

Subjects
Rehabilitation -- Usage -- Analysis -- Health aspects, Walking -- Health aspects -- Analysis -- Usage, Health
Abstract

Background. Commonly used activity monitors have been shown to be accurate in counting steps in active people; however, further validation is needed in slower walking populations. Objectives. To determine the [...]

Published
2017
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41. Implementation of a Project-Based Molecular Biology Laboratory Emphasizing Protein Structure-Function Relationships in a Large Introductory Biology Laboratory Course

Author

Treacy, Daniel J., Sankaran, Saumya M., and Gordon-Messer, Susannah

Abstract

In introductory laboratory courses, many universities are turning from traditional laboratories with predictable outcomes to inquiry-inspired, project-based laboratory curricula. In these labs, students are allowed to design at least some portion of their own experiment and interpret new, undiscovered data. We have redesigned the introductory biology laboratory course at Brandeis University into a semester-long project-based laboratory that emphasizes concepts and contains an element of scientific inquiry. In this laboratory, students perform a site-directed mutagenesis experiment on the gene encoding human [gamma]D crystallin, a human eye lens protein implicated in cataracts, and assess the stability of their newly created protein with respect to wild-type crystallin. This laboratory utilizes basic techniques in molecular biology to emphasize the importance of connections between DNA and protein. This project lab has helped engage students in their own learning, has improved students' skills in critical thinking and analysis, and has promoted interest in basic research in biology. (Contains 4 tables.)

Published
2011
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43. Mobility training for increasing mobility and functioning in older people with frailty

Author

Treacy, Daniel, Hassett, Leanne, Schurr, Karl, Fairhall, Nicola J, Cameron, Ian D, and Sherrington, Catherine

Subjects
Aged, 80 and over, Frailty, Quality of Life, Humans, Pharmacology (medical), Independent Living, Exercise, Aged, Exercise Therapy
Abstract

BACKGROUND: Frailty is common in older people and is characterised by decline across multiple body systems, causing decreased physiological reserve and increased vulnerability to adverse health outcomes. It is estimated that 21% of the community‐dwelling population over 65 years are frail. Frailty is independently predictive of falls, worsening mobility, deteriorating functioning, impaired activities of daily living, and death. The World Health Organization's International Classification of Functioning, Disability and Health (ICF) defines mobility as: changing and maintaining a body position, walking, and moving. Common interventions used to increase mobility include functional exercises, such as sit‐to‐stand, walking, or stepping practice. OBJECTIVES: To summarise the evidence for the benefits and safety of mobility training on overall functioning and mobility in frail older people living in the community. SEARCH METHODS: We searched CENTRAL, MEDLINE, Embase, AMED, PEDro, US National Institutes of Health Ongoing Trials Register, and the World Health Organization International Clinical Trials Registry Platform (June 2021). SELECTION CRITERIA: We included randomised controlled trials (RCTs) evaluating the effects of mobility training on mobility and function in frail people aged 65+ years living in the community. We defined community as those residing either at home or in places that do not provide rehabilitative services or residential health‐related care, for example, retirement villages, sheltered housing, or hostels. DATA COLLECTION AND ANALYSIS: We undertook an 'umbrella' comparison of all types of mobility training versus control. MAIN RESULTS: This review included 12 RCTs, with 1317 participants, carried out in 9 countries. The median number of participants in the trials was 97. The mean age of the included participants was 82 years. The majority of trials had unclear or high risk of bias for one or more items. All trials compared mobility training with a control intervention (defined as one that is not thought to improve mobility, such as general health education, social visits, very gentle exercise, or "sham" exercise not expected to impact on mobility). High‐certainty evidence showed that mobility training improves the level of mobility upon completion of the intervention period. The mean mobility score was 4.69 in the control group, and with mobility training, this score improved by 1.00 point (95% confidence interval (CI) 0.51 to 1.51) on the Short Physical Performance Battery (on a scale of 0 to 12; higher scores indicate better mobility levels) (12 studies, 1151 participants). This is a clinically significant change (minimum clinically important difference: 0.5 points; absolute improvement of 8% (4% higher to 13% higher); number needed to treat for an additional beneficial outcome (NNTB) 5 (95% CI 3.00 to 9.00)). This benefit was maintained at six months post‐intervention. Moderate‐certainty evidence (downgraded for inconsistency) showed that mobility training likely improves the level of functioning upon completion of the intervention. The mean function score was 86.1 in the control group, and with mobility training, this score improved by 8.58 points (95% CI 3.00 to 14.30) on the Barthel Index (on a scale of 0 to 100; higher scores indicate better functioning levels) (9 studies, 916 participants) (absolute improvement of 9% (3% higher to 14% higher)). This result did not reach clinical significance (9.8 points). This benefit did not appear to be maintained six months after the intervention. We are uncertain of the effect of mobility training on adverse events as we assessed the certainty of the evidence as very low (downgraded one level for imprecision and two levels for bias). The number of events was 771 per 1000 in the control group and 562 per 1000 in the group with mobility training (risk ratio (RR) 0.74, 95% CI 0.63 to 0.88; 2 studies, 225 participants) (absolute difference of 19% fewer (9% fewer to 26% fewer)). Mobility training may result in little to no difference in the number of people who are admitted to nursing care facilities at the end of the intervention period as the 95% confidence interval includes the possibility of both a reduced and increased number of admissions to nursing care facilities (low‐certainty evidence, downgraded for imprecision and bias). The number of events was 248 per 1000 in the control group and 208 per 1000 in the group with mobility training (RR 0.84, 95% CI 0.53 to 1.34; 1 study, 241 participants) (absolute difference of 4% fewer (8% more to 12% fewer)). Mobility training may result in little to no difference in the number of people who fall as the 95% confidence interval includes the possibility of both a reduced and increased number of fallers (low‐certainty evidence, downgraded for imprecision and study design limitations). The number of events was 573 per 1000 in the control group and 584 per 1000 in the group with mobility training (RR 1.02, 95% CI 0.87 to 1.20; 2 studies, 425 participants) (absolute improvement of 1% (12% more to 7% fewer)). Mobility training probably results in little to no difference in the death rate at the end of the intervention period as the 95% confidence interval includes the possibility of both a reduced and increased death rate (moderate‐certainty evidence, downgraded for bias). The number of events was 51 per 1000 in the control group and 59 per 1000 in the group with mobility training (RR 1.16, 95% CI 0.64 to 2.10; 6 studies, 747 participants) (absolute improvement of 1% (6% more to 2% fewer)). AUTHORS' CONCLUSIONS: The data in the review supports the use of mobility training for improving mobility in a frail community‐dwelling older population. High‐certainty evidence shows that compared to control, mobility training improves the level of mobility, and moderate‐certainty evidence shows it may improve the level of functioning in frail community‐dwelling older people. There is moderate‐certainty evidence that the improvement in mobility continues six months post‐intervention. Mobility training may make little to no difference to the number of people who fall or are admitted to nursing care facilities, or to the death rate. We are unsure of the effect on adverse events as the certainty of evidence was very low.

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2022
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44. Economic evaluation of digitally enabled aged and neurological rehabilitation care in the Activity and MObility UsiNg Technology (AMOUNT) trial.

Author

Pinheiro, Marina B, Hassett, Leanne, Sherrington, Catherine, Hayes, Alison, van den Berg, Maayken, Lindley, Richard I, Crotty, Maria, Chagpar, Sakina, Treacy, Daniel, Weber, Heather, Fairhall, Nicola, Wong, Siobhan, McCluskey, Annie, Togher, Leanne, Scrivener, Katharine, and Howard, Kirsten

Subjects
NEUROLOGICAL disorders, EVALUATION of human services programs, CONFIDENCE intervals, CLINICAL trials, DIGITAL technology, PHYSICAL activity, RANDOMIZED controlled trials, COST effectiveness, PHYSICAL mobility, DESCRIPTIVE statistics, QUESTIONNAIRES, RESEARCH funding, STATISTICAL sampling, EXERCISE therapy, QUALITY-adjusted life years
Abstract

Objective: To investigate the trial-based cost-effectiveness of the addition of a tailored digitally enabled exercise intervention to usual care shown to be clinically effective in improving mobility in the Activity and MObility UsiNg Technology (AMOUNT) rehabilitation trial compared to usual care alone. Design: Economic evaluation alongside a pragmatic randomized controlled trial. Participants: 300 people receiving inpatient aged and neurological rehabilitation were randomized to the intervention (n = 149) or usual care control group (n = 151). Main measures: Incremental cost effectiveness ratios were calculated for the additional costs per additional person demonstrating a meaningful improvement in mobility (3-point in Short Physical Performance Battery) and quality-adjusted life years gained at 6 months (primary analysis). The joint probability distribution of costs and outcomes was examined using bootstrapping. Results: The mean cost saving for the intervention group at 6 months was AU$2286 (95% Bootstrapped cost CI: −$11,190 to $6410) per participant; 68% and 67% of bootstraps showed the intervention to be dominant (i.e. more effective and cost saving) for mobility and quality-adjusted life years, respectively. The probability of the intervention being cost-effective considering a willingness to pay threshold of AU$50,000 per additional person with a meaningful improvement in mobility or quality-adjusted life year gained was 93% and 77%, respectively. Conclusions: The AMOUNT intervention had a high probability of being cost-effective if decision makers are willing to pay AU$50,000 per meaningful improvement in mobility or per quality-adjusted life year gained, and a moderate probability of being cost-saving and effective considering both outcomes at 6 months post randomization. [ABSTRACT FROM AUTHOR]

Published
2023
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47. sj-pdf-1-cre-10.1177_02692155221138920 - Supplemental material for Economic evaluation of digitally enabled aged and neurological rehabilitation care in the Activity and MObility UsiNg Technology (AMOUNT) trial

Author

Pinheiro, Marina B, Hassett, Leanne, Sherrington, Catherine, Hayes, Alison, van den Berg, Maayken, Lindley, Richard I, Crotty, Maria, Chagpar, Sakina, Treacy, Daniel, Weber, Heather, Fairhall, Nicola, Wong, Siobhan, McCluskey, Annie, Togher, Leanne, Scrivener, Katharine, and Howard, Kirsten

Subjects
FOS: Clinical medicine, 110604 Sports Medicine, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases, 110314 Orthopaedics
Abstract

Supplemental material, sj-pdf-1-cre-10.1177_02692155221138920 for Economic evaluation of digitally enabled aged and neurological rehabilitation care in the Activity and MObility UsiNg Technology (AMOUNT) trial by Marina B Pinheiro, Leanne Hassett, Catherine Sherrington, Alison Hayes and Maayken van den Berg, Richard I Lindley, Maria Crotty, Sakina Chagpar, Daniel Treacy, Heather Weber, Nicola Fairhall, Siobhan Wong, Annie McCluskey, Leanne Togher, Katharine Scrivener, Kirsten Howard in Clinical Rehabilitation

Published
2022
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48. Additional file 2 of Planning implementation and scale-up of physical activity interventions for people with walking difficulties: study protocol for the process evaluation of the ComeBACK trial

Author

Wong, Siobhan, Hassett, Leanne, Koorts, Harriet, Grunseit, Anne, Tong, Allison, Tiedemann, Anne, Greaves, Colin J., Haynes, Abby, Milat, Andrew, Harvey, Lisa A., Taylor, Nicholas F., Hinman, Rana S., Pinherio, Marina De Barros, Jennings, Matthew, Treacy, Daniel, O���Rourke, Sandra, West, Courtney, Ramsay, Elizabeth, Kirkham, Catherine, Morris, Claire, and Sherrington, Catherine

Subjects
ComputerApplications_MISCELLANEOUS, Data_FILES
Abstract

Additional file 2. Impressions of the program questionnaire.

Published
2022
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49. Additional file 1 of Planning implementation and scale-up of physical activity interventions for people with walking difficulties: study protocol for the process evaluation of the ComeBACK trial

Author

Wong, Siobhan, Hassett, Leanne, Koorts, Harriet, Grunseit, Anne, Tong, Allison, Tiedemann, Anne, Greaves, Colin J., Haynes, Abby, Milat, Andrew, Harvey, Lisa A., Taylor, Nicholas F., Hinman, Rana S., Pinherio, Marina De Barros, Jennings, Matthew, Treacy, Daniel, O���Rourke, Sandra, West, Courtney, Ramsay, Elizabeth, Kirkham, Catherine, Morris, Claire, and Sherrington, Catherine

Abstract

Additional file 1. ComeBACK interview guides.

Published
2022
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50. sj-docx-2-cre-10.1177_02692155221138920 - Supplemental material for Economic evaluation of digitally enabled aged and neurological rehabilitation care in the Activity and MObility UsiNg Technology (AMOUNT) trial

Author

Pinheiro, Marina B, Hassett, Leanne, Sherrington, Catherine, Hayes, Alison, van den Berg, Maayken, Lindley, Richard I, Crotty, Maria, Chagpar, Sakina, Treacy, Daniel, Weber, Heather, Fairhall, Nicola, Wong, Siobhan, McCluskey, Annie, Togher, Leanne, Scrivener, Katharine, and Howard, Kirsten

Subjects
FOS: Clinical medicine, 110604 Sports Medicine, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases, 110314 Orthopaedics
Abstract

Supplemental material, sj-docx-2-cre-10.1177_02692155221138920 for Economic evaluation of digitally enabled aged and neurological rehabilitation care in the Activity and MObility UsiNg Technology (AMOUNT) trial by Marina B Pinheiro, Leanne Hassett, Catherine Sherrington, Alison Hayes and Maayken van den Berg, Richard I Lindley, Maria Crotty, Sakina Chagpar, Daniel Treacy, Heather Weber, Nicola Fairhall, Siobhan Wong, Annie McCluskey, Leanne Togher, Katharine Scrivener, Kirsten Howard in Clinical Rehabilitation

Published
2022
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