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3. Imaging-Derived Biomarkers Integrated with Clinical and Laboratory Values Predict Recurrence of Hepatocellular Carcinoma After Liver Transplantation

Author

Hoang TPT, Schindler P, Börner N, Masthoff M, Gerwing M, von Beauvais P, De Toni EN, Lange CM, Trebicka J, Morgül H, Seidensticker M, Ricke J, Pascher A, Guba M, Ingrisch M, Wildgruber M, and Öcal O

Subjects
hepatocellular carcinoma, transplantation, imaging, recurrence, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Thi Phuong Thao Hoang,1 Philipp Schindler,2 Nikolaus Börner,3 Max Masthoff,2 Mirjam Gerwing,2 Philippa von Beauvais,2 Enrico N De Toni,4 Christian M Lange,4 Jonel Trebicka,5 Haluk Morgül,6 Max Seidensticker,1 Jens Ricke,1 Andreas Pascher,6 Markus Guba,3 Michael Ingrisch,1 Moritz Wildgruber,1,* Osman Öcal1,* 1Department of Radiology, University Hospital, LMU Munich, Munich, Germany; 2Clinic for Radiology, University Hospital Muenster, Muenster, Germany; 3Department of General, Visceral and Transplantation Surgery, University Hospital, LMU Munich, Munich, Germany; 4Department for Internal Medicine II, University Hospital, LMU Munich, Munich, Germany; 5Department for Internal Medicine B, Universitätsklinikum Münster, Münster, Germany; 6Department of General, Visceral and Transplant Surgery, Universitätsklinikum Münster, Münster, Germany*These authors contributed equally to this workCorrespondence: Osman Öcal, Department of Radiology, University Hospital – LMU Munich, Marchioninistrasse 15, D-81377, München, Germany, Email osman.oecal@med.uni-muenchen.dePurpose: To investigate the prognostic value of computed tomography (CT) derived imaging biomarkers in hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT) and develop a predictive nomogram model.Patients and Methods: This retrospective study included 178 patients with histopathologically confirmed HCC who underwent liver transplantation between 2007 and 2021 at the two academic liver centers. We evaluated dedicated imaging features from baseline multiphase contrast-enhanced CT supplemented by several clinical findings and laboratory parameters. Time-to-recurrence was estimated by Kaplan–Meier analysis. Univariable Cox proportional hazard regression and multivariable Least Absolute Shrinkage and Selection Operator (LASSO) regression were used to assess independent prognostic factors for recurrence. A nomogram model was then built based on the independent factors selected through LASSO regression, to predict the probabilities of HCC recurrence at one, three, and five years.Results: The rate of HCC recurrence after LT was 17.4% (31 of 178). The LASSO analysis revealed six independent predictors associated with an elevated risk of tumor recurrence. These predictors included the presence of peritumoral enhancement, the presence of over three tumor lesions, the largest tumor diameter greater than 3 cm, serum alpha-fetoprotein (AFP) levels exceeding 400 ng/mL, and the presence of a tumor capsule. Conversely, a history of bridging therapies was found to be correlated with a reduced risk of HCC recurrence. In addition, Kaplan-Meier curves showed patients with irregular margin, satellite nodules, or small lesions displayed shorter time-to-recurrence. Our nomogram demonstrated good performance, yielding a C-index of 0.835 and AUC values of 0.86, 0.88, and 0.85 for the predictions of 1-year, 3-year, and 5-year TTR, respectively.Conclusion: Imaging parameters derived from baseline contrast-enhanced CT showing malignant behavior and aggressive growth patterns, along with serum AFP and history of bridging therapies, show potential as biomarkers for predicting HCC recurrence after transplantation.Keywords: hepatocellular carcinoma, transplantation, imaging, recurrence

Published
2023

4. Rare HCV subtypes and retreatment outcomes in a cohort of European DAA-experienced patients

Author

Antoni, C., Teufel, A., Vogelmann, R., Ebert, M., Balavoine, J., Giostra, E., Berning, M., Hampe, J., Boettler, T., Neumann-Haefelin, C., Thimme, R., De Gottardi, A., Rauch, A., Semmo, N., Ellenrieder, V., Gress, M., Herrmann, A., Stallmach, A., Hoffmann, D., Protzer, U., Kodal, A., Löbermann, M., Götze, T., Keitel-Anselmino, V., Lange, C.M., Zachoval, R., Mayerle, J., Maieron, A., Michl, P., Merle, U., Moradpour, D., Chave, J.-P., Muche, M., Epple, H.-J., Müller-Schilling, M., Kocheise, F., Müller, T., Tacke, F., Roeb, E., Rissland, J., Krawczyk, M., Schulze, P., Semela, D., Spengler, U., Rockstroh, J., Strassburg, C.P., Siebler, J., Schulze zur Wiesch, J., Piecha, F., von Felden, J., Jordan, S., Lohse, A., Sprinzl, M., Galle, P., Stauber, R., Strey, B., Steckstor, W., Schmiegel, W., Brockmeyer, N.H., Canbay, A., Trautwein, C., Uschner, F., Trebicka, J., Weber, T., Wedemeyer, H., Cornberg, M., Manns, M., Wietzke-Braun, P., Günther, R., Willuweit, K., Hilgard, G., Schmidt, H., Zizer, E., Backhus, J., Seufferlein, T., Al-Taie, O., Angeli, W., Beckebaum, S., Erhardt, A., Garrido-Lüneburg, A., Gattringer, H., Genné, D., Gschwantler, M., Gundling, F., Hametner, S., Schöfl, R., Haag, S., Heinzow, H., Heyer, T., Hirschi, C., Jussios, A., Kanzler, S., Kordecki, N., Kraus, M., Kullig, U., Wollschläger, S., Magenta, L., Beretta-Piccoli, B. Terziroli, Menges, M., Mohr, L., Muehlenberg, K., Niederau, C., Paulweber, B., Petrides, A., Pinkernell, M., Piso, R., Rambach, W., Reinhardt, L., Reiser, M., Riecken, B., Rieke, A., Roth, J., Schelling, M., Schlee, P., Schneider, A., Scholz, D., Schott, E., Schuchmann, M., Schulten-Baumer, U., Seelhoff, A., Stich, A., Stickel, F., Ungemach, J., Walter, E., Weber, A., Wege, H., Winzer, T., Abels, W., Adler, M., Audebert, F., Baermann, C., Bästlein, E., Barth, R., Barthel, K., Becker, W., Behrends, J., Benninger, J., Berger, F., Berzow, D., Beyer, T., Bierbaum, M., Blaukat, O., Bodtländer, A., Böhm, G., Börner, N., Bohr, U., Bokemeyer, B., Bruch, H.R., Bucholz, D., Buggisch, P., Matschenz, K., Petersen, J., Burkhard, O., Busch, N., Chirca, C., Delker, R., Diedrich, J., Frank, M., Diehl, M., Tal, A.O., Schneider, M., Dienethal, A., Dietel, P., Dikopoulos, N., Dreck, M., Dreher, F., Drude, L., Ende, K., Ehrle, U., Baumgartl, K., Emke, F., Glosemeyer, R., Felten, G., Hüppe, D., Fischer, J., Fischer, U., Frederking, D., Frick, B., Friese, G., Gantke, B., Geyer, P., Schwind, H.R., Glas, M., Glaunsinger, T., Goebel, F., Göbel, U., Görlitz, B., Graf, R., Gruber, H., Hartmann, C., Klag, C., Härter, G., Herder, M., Heuchel, T., Heuer, S., Hinrichsen, H., Seegers, B., Höffl, K.-H., Hörster, H., Sonne, J.-U., Hofmann, W.P., Holst, F., Hunstiger, M., Hurst, A., Jägel-Guedes, E., John, C., Jung, M., Kallinowski, B., Kapzan, B., Kerzel, W., Khaykin, P., Klarhof, M., Klüppelberg, U., Wolfratshausen, Klugewitz, K., Knapp, B., Knevels, U., Kochsiek, T., Körfer, A., Köster, A., Kuhn, M., Langekamp, A., Künzig, B., Link, R., Littman, M., Löhr, H., Lutz, T., Gute, P., Knecht, G., Lutz, U., Mainz, D., Mahle, I., Maurer, P., Mauss, S., Mayer, C., Möller, H., Heyne, R., Moritzen, D., Mroß, M., Mundlos, M., Naumann, U., Nehls, O., K, Ningel, R., Oelmann, A., Olejnik, H., Gadow, K., Pascher, E., Philipp, A., Pichler, M., Polzien, F., Raddant, R., Riedel, M., Rietzler, S., Rössle, M., Rufle, W., Rump, A., Schewe, C., Hoffmann, C., Schleehauf, D., Schmidt, W., Schmidt-Heinevetter, G., Fabris, J. Schmidtler-von, Schneider, L., Schober, A., Niehaus-Hahn, S., Schwenzer, J., Seidel, T., Seitel, G., Sick, C., Simon, K., Stähler, D., Stenschke, F., Steffens, H., Stein, K., Steinmüller, M., Sternfeld, T., Svensson, K., Tacke, W., Teuber, G., Teubner, K., Thieringer, J., Tomesch, A., Trappe, U., Ullrich, J., Urban, G., Usadel, S., von Lucadou, A., Weinberger, F., Werheid-Dobers, M., Werner, P., Winter, T., Zehnter, E., Zipf, A., Dietz, Julia, Graf, Christiana, Berg, Christoph P., Port, Kerstin, Deterding, Katja, Buggisch, Peter, Peiffer, Kai-Henrik, Vermehren, Johannes, Dultz, Georg, Geier, Andreas, Reiter, Florian P., Bruns, Tony, Schattenberg, Jörn M., Durmashkina, Elena, Gustot, Thierry, Moreno, Christophe, Trauth, Janina, Discher, Thomas, Fischer, Janett, Berg, Thomas, Kremer, Andreas E., Müllhaupt, Beat, Zeuzem, Stefan, and Sarrazin, Christoph

Published
2024
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6. Transjugular Intrahepatic Portosystemic Shunt improves rebleeding and survival in gastric variceal hemorrhage

Author

Sanoubara, F., additional, Kimmann, M., additional, Gödiker, J., additional, Groba, S. N. Reinartz, additional, Weppelmann, F., additional, Chang, J., additional, Jansen, C., additional, Meyer, C., additional, Köhler, M., additional, Laleman, W., additional, Trebicka, J., additional, Meier, J. A., additional, and Praktiknjo, M., additional

Published
2024
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7. Factors Associated with Infectious Complications Following Endoscopic Retrograde Cholangiopancreatography in Liver Transplant Recipients: Insights from a Single-Center Study

Author

Kühl, N., additional, Vollenberg, R., additional, Meier, J. A., additional, Ullerich, H., additional, Schulz, M. S., additional, Rennebaum, F., additional, Laleman, W., additional, Froboese, N. J., additional, Praktiknjo, M., additional, Peiffer, K., additional, Fischer, J., additional, Trebicka, J., additional, Gu, W., additional, and Tepasse, P. R., additional

Published
2024
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18. Einfluss von Aspirin auf das transplantationsfreie Überleben nach der Anlage eines transjugulären intrahepatischen portosystemischen Shunts (TIPS): eine retrospektive multizentrische Analyse

Author

Schindler, P, additional, Seifert, L L, additional, Masthoff, M, additional, Jansen, C, additional, Meyer, C, additional, Wilms, C, additional, Schultheiß, M, additional, Bettinger, D, additional, Trebicka, J, additional, Heinzow, H, additional, Köhler, M, additional, and Wildgruber, M, additional

Published
2022
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21. Variceal bleeding

Author

Sauerbruch, T., Trebicka, J., Ferkolj, I., editor, Gangl, A., editor, Galle, P. R., editor, and Vucelic, B., editor

Published
2008
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23. Corrigendum to ‘Baveno VII – Renewing consensus in portal hypertension’ [J Hepatol (2022) 959-974, (S0168827821022996), (10.1016/j.jhep.2021.12.022)]

Author

de Franchis, R., Bosch, J., Garcia-Tsao, G., Reiberger, T., Ripoll, C., Abraldes, J. G., Albillos, A., Baiges, A., Bajaj, J., Banares, R., Barrufet, M., Benajiba, L., Berzigotti, A., Bureau, C., Calvaruso, V., Cardenas, A., D'Amico, G., De Gottardi, A., Dell'Era, A., Escorsell, A., Fallowfield, J., Ferral, H., Francque, S., Gaba, R., Garcia-Pagan, J. C., Genesca, J., Rodrigues, S. G., Gracia-Sanscho, J., Han, G., Hernandez-Gea, V., Jia, J., Kiladjian, J. J., Krag, A., Laleman, W., La Mura, V., Lens, S., Luo, X., Mandorfer, M., Murad, S. D., Paradis, V., Patch, D., Piano, S., Pinzani, M., Plessier, A., Primignani, M., Procopet, B., Rautou, P. E., Rudler, M., Sarin, S. K., Schepis, F., Senzolo, M., Shah, V., Shukla, A., Tandon, P., Tellez, L., Thabut, D., Thiele, M., Trebicka, J., Tripathi, D., Tsochatzis, E., Turco, L., Turon, F., Valla, D., Villanueva, C., Wanless, I., and Yoshiji, H.

Published
2022

24. Die kraniale Position des Transjugulären Intrahepatischen Portosystemischen Shunt Stents ist unabhängig mit der Entwicklung einer Shuntdysfunktion assoziiert

Author

Praktiknjo, M, additional, PaarPérez, AM, additional, Chang, J, additional, Sprinkart, AM, additional, Böhling, N, additional, Jansen, C, additional, Luetkens, J, additional, Attenberger, U, additional, Strassburg, CP, additional, Trebicka, J, additional, Wolter, K, additional, and Meyer, C, additional

Published
2021
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26. Mikrobielle Dysbiose fördert die Hepatokarzinogenese über eine Veränderung des hepatischen Entzündungsmillieus

Author

Schneider, KM, additional, Mohs, A, additional, Gui, W, additional, Galvez, EJC, additional, Candels, LS, additional, Holland, CH, additional, Elfers, C, additional, Kilic, K, additional, Schneider, CV, additional, Strnad, P, additional, Wirtz, TH, additional, Marshall, HU, additional, Latz, E, additional, Lelouvier, B, additional, Saez-Rodriguez, J, additional, de Vos, W, additional, Strowig, T, additional, Trebicka, J, additional, and Trautwein, C, additional

Published
2021
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30. Variants APOE (rs429358) and TM6SF2 (rs187429064) confer risk to hepatocellular carcinoma

Author

Innes, H, additional, Nischalke, HD, additional, Rosendahl, J, additional, Weiss, KH, additional, Sulk, S, additional, Müller, S, additional, Fischer, J, additional, Casper, M, additional, Gotthardt, D, additional, Lammert, F, additional, Lutz, PL, additional, Semmler, G, additional, Eyer, F, additional, von Felden, J, additional, Link, A, additional, Vogel, A, additional, Guha, IN, additional, Marquardt, J, additional, Trebicka, J, additional, Barnes, E, additional, Valenti, L, additional, Datz, C, additional, Irving, W, additional, JR, Morling, additional, Hamill, V, additional, McLauchlan, J, additional, Benselin, J, additional, Marot, A, additional, Pedergnana, V, additional, Reiberger, T, additional, Ansari, A, additional, Schafmayer, C, additional, Berg, T, additional, Deltenre, P, additional, Stickel, F, additional, Hampe, J, additional, and Buch, S, additional

Published
2021
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31. Präoperativer transjugulärer intrahepatischer portosystemischer Shunt reduziert das Auftreten von postoperativem Akut-auf-chronische Leberversagen bei Patienten mit hohem CLIF-C AD score

Author

Praktiknjo, M, additional, Höfer, P, additional, Böhling, N, additional, Lingohr, P, additional, Manekeller, S, additional, Kalff, JC, additional, Jansen, C, additional, Meyer, C, additional, Strassburg, CP, additional, Trebicka, J, additional, and Chang, J, additional

Published
2021
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32. Multidrug-resistant organisms predispose to relapsing cholangitis in liver graft recipients with stenosis of the biliary anastomosis

Author

Ferstl, PG, additional, Bremer, K, additional, Filmann, N, additional, Queck, A, additional, Weiler, N, additional, Trebicka, J, additional, Welker, MW, additional, Waidmann, O, additional, Bechstein, WO, additional, Kempf, VAJ, additional, Hogardt, M, additional, Zeuzem, S, additional, Friedrich-Rust, M, additional, and Walter, D, additional

Published
2021
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34. Porto-sinusoidal vascular disease: proposal and description of a novel entity

Author

De Gottardi, A, Rautou, PE, Schouten, Joanne, Rubbia-Brandt, L, Leebeek, Frank, Trebicka, J, Darwish Murad, Sarwa, Vilgrain, V, Hernandez-Gea, V, Nery, F, Plessier, A, Berzigotti, A, Bioulac-Sage, P, Primignani, M, Seinela, D, Elkrief, L, Bedossa, P, Willa, D, Garcia-Pagan, JC, Jakob, B, Cazals-Hatem, D, Alonso, C, Erasmus MC other, Hematology, and Gastroenterology & Hepatology

Subjects
Pathology, medicine.medical_specialty, Cirrhosis, ddc:616.07, 03 medical and health sciences, Liver disease, 0302 clinical medicine, Incomplete septal cirrhosis, Venules, 600 Technology, Hypertension, Portal, medicine, Humans, Vascular Diseases, 610 Medicine & health, ddc:617, Hepatology, medicine.diagnostic_test, Portal Vein, Vascular disease, business.industry, Gastroenterology, medicine.disease, Capillaries, Portal vein thrombosis, Portal System, 030220 oncology & carcinogenesis, Liver biopsy, Portal hypertension, 030211 gastroenterology & hepatology, business, Nodular regenerative hyperplasia
Abstract

Portal hypertension in the absence of portal vein thrombosis and without cirrhosis, but with mild or moderate alterations of liver histology (eg, obliterative venopathy, nodular regenerative hyperplasia, or incomplete septal cirrhosis) is being increasingly recognised. Owing to the heterogeneity of causes and histological findings, a substantial number of terms have been used to describe such idiopathic non-cirrhotic portal hypertension. Patients with the same clinical and histological features exist, but without portal hypertension at the time of diagnosis. Therefore, improved criteria are needed to define this form of liver disease. Here, we propose the term porto-sinusoidal vascular disease, since all lesions found involve the portal venules or sinusoids. The definition of this entity is based on the characteristic absence of cirrhosis with or without signs of portal hypertension or histological lesions. The presence of known causes of liver disease does not rule out porto-sinusoidal vascular disease, but specific causes of vascular liver disease are excluded from its definition. The diagnosis of porto-sinusoidal vascular disease is based on liver biopsy and might include signs specific for portal hypertension with normal or mildly elevated liver stiffness values and no complete portal vein thrombosis. We provide simple diagnostic criteria, because agreement on a uniform nomenclature is an essential requirement for future collaborative studies.

Published
2019

36. Modifikation des CLIF-C ACLF-Scores für die Prognoseabschätzung bei Schutzintubation und Lungenversagen.

Author

Schulz, M, additional, Mengers, J, additional, Ferstl, PG, additional, Uschner, FE, additional, Queck, A, additional, Brol, MJ, additional, Ackermann, N, additional, Guttenberg, G, additional, Graf, C, additional, Mücke, MM, additional, Peiffer, KH, additional, Welker, MW, additional, Grünewaldt, A, additional, Bojunga, J, additional, Zeuzem, S, additional, Rohde, G, additional, and Trebicka, J, additional

Published
2021
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41. Epidemiologie von gesicherten bakteriellen Infektionen bei Patienten mit Leberzirrhose in den Jahren von 2010 bis 2019

Author

Ferstl, P, additional, Picard, K, additional, Schmuck, L, additional, Krajnc, JR, additional, Feller, L, additional, Schultze, TG, additional, Schulz, M, additional, Uschner, FE, additional, Erasmus, HP, additional, Gu, W, additional, Mücke, MM, additional, Wichelhaus, TA, additional, Hogardt, M, additional, Waidmann, O, additional, Welker, MW, additional, Zeuzem, S, additional, Kempf, VAJ, additional, and Trebicka, J, additional

Published
2021
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45. Mechanisms of extrahepatic vasodilation in portal hypertension

Author

Hennenberg, M., Trebicka, J., Sauerbruch, T., and Heller, J.

Subjects
Portal hypertension -- Development and progression, Portal hypertension -- Forecasts and trends, Protein kinases -- Physiological aspects, Blood vessels -- Dilatation, Blood vessels -- Physiological aspects, Market trend/market analysis, Health
Published
2008

46. Blood metabolomics uncovers inflammation-associated mitochondrial dysfunction as a potential mechanism underlying ACLF (vol 72, pg 688, 2020)

Author

Moreau, R, Claria, J, Aguilar, F, Fenaille, F, Lozano, JJ, Junot, C, Colsch, B, Caraceni, P, Trebicka, J, Pavesi, M, Alessandria, C, Nevens, F, Saliba, F, Welzel, TM, Albillos, A, Gustot, T, Fernandez, J, Moreno, C, Baldassarre, M, Zaccherini, G, Piano, S, Montagnese, S, Vargas, V, Genesca, J, Sola, E, Bernal, W, Butin, N, Hautbergue, T, Cholet, S, Castelli, F, Jansen, C, Steib, C, Campion, D, Mookerjee, R, Rodriguez-Gandia, M, Soriano, G, Durand, F, Benten, D, Banares, R, Stauber, RE, Gronbaek, H, Coenraad, MJ, Gines, P, Gerbes, A, Jalan, R, Bernardi, M, Arroyo, V, Angeli, P, CANONIC Study, and Grifols Chair European

Published
2020

47. Intrahepatic upregulation of RhoA and Rho-kinase signalling contributes to increased hepatic vascular resistance in rats with secondary biliary cirrhosis

Author

Zhou, Q., Hennenberg, M., Trebicka, J., Jochem, K., Leifeld, L., Biecker, E., Sauerbruch, T., and Heller, J.

Subjects
Biliary cirrhosis -- Physiological aspects, Biliary cirrhosis -- Research, Portal hypertension -- Physiological aspects, Portal hypertension -- Research, Guanosine triphosphatase -- Analysis, Cellular signal transduction -- Research, Health
Published
2006

49. Die Rolle von elektiven Eingriffen als auslösende Faktoren für die Entwicklung von Akut-auf-chronischem Leberversagen

Author

Chang, J, additional, Bamarni, A, additional, Böhling, N, additional, Zhou, X, additional, Meinke, J, additional, Duerr, GD, additional, Lingohr, P, additional, Wehner, S, additional, Stoffels-Wagner, B, additional, Dolscheid-Pommerich, R, additional, Kristiansen, G, additional, Jansen, C, additional, Rockstroh, J, additional, Kalff, J, additional, Manekeller, S, additional, Spengler, U, additional, Strassburg, CP, additional, Trebicka, J, additional, and Praktiknjo, M, additional

Published
2020
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50. The bacterial bile microbiome and its role in liver diseases

Author

Tyc, O, additional, Jansen, C, additional, Schierwagen, R, additional, Uschner, F, additional, Israelsen, M, additional, Klein, S, additional, Ortiz, C, additional, Strassburg, C, additional, Zeuzem, S, additional, Gu, W, additional, Torres, S, additional, Praktiknjo, M, additional, Kersting, S, additional, Langheinrich, M, additional, Nattermann, J, additional, Servant, F, additional, Arumugam, M, additional, Krag, A, additional, Lelouvier, B, additional, Weismüller, T, additional, and Trebicka, J, additional

Published
2020
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