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While most Tripartite motif (TRIM) family proteins are E3 ubiquitin ligases, some members have functions beyond the regulation of ubiquitination, impacting normal physiological processes and disease progression. TRIM29, an important member of the TRIM family, exerts a predominant influence on cancer growth, epithelial-to-mesenchymal transition, stemness and metastatic progression by directly potentiating multiple canonical oncogenic pathways. The cancer-promoting effect of TRIM29 is also evident in metabolic interventions and interference with the efficacy of cancer therapeutics. As expected for any key node in cancer, the expression of TRIM29 is tightly regulated by non-coding RNAs, epigenetic modulation, and post-translational regulation. A systematic discussion of how TRIM29 is regulated in cancer, its influences on cancer progression, and its impact on cancer therapeutics is presented in this review. We also explore the context-dependent alterations between TRIM29 function from oncogenic to tumor suppression. As TRIM29 is involved in multiple aspects of cancer progression, a better understanding of its biological impact in cancer may help improve prognosis and develop novel therapeutic combinations, leading to improved personalized cancer care. [ABSTRACT FROM AUTHOR]

The microtubule network is formed from polymerised tubulin subunits and associating proteins, which govern microtubule dynamics and a diverse array of functions. To identify novel microtubule-binding proteins, we have developed an unbiased biochemical assay, which relies on the selective extraction of cytosolic proteins from U2OS cells, while leaving behind the microtubule network. Candidate proteins are linked to microtubules by their sensitivities to the depolymerising drug nocodazole or the microtubule-stabilising drug taxol, which is quantitated by mass spectrometry. Our approach is benchmarked by co-segregation of tubulin and previously established microtubule-binding proteins. We then identify several novel candidate microtubule-binding proteins, from which we have selected the ubiquitin E3 ligase tripartite motif-containing protein 3 (TRIM3) for further characterisation. We map TRIM3 microtubule binding to its C-terminal NHL-repeat region. We show that TRIM3 is required for the accumulation of acetylated tubulin, following treatment with taxol. Furthermore, loss of TRIM3 partially recapitulates the reduction in nocodazole-resistant microtubules characteristic of a-tubulin acetyltransferase 1 (ATAT1) depletion. These results can be explained by a decrease in ATAT1 following depletion of TRIM3 that is independent of transcription. [ABSTRACT FROM AUTHOR]

Globally, the grey-headed albatross Thalassarche chrysostoma is listed as Endangered due to decreasing populations at its major breeding colonies. We analysed the population trend at Marion Island using annual counts of incubating pairs and fledglings from 1984 to 2021 and three methods: TRends and Indices for Monitoring data (TRIM), a generalized additive model and a state-space model. In contrast to rapid decreases at most other colonies, all three methods indicated a local population increase at an average annual rate of 1.3%. The latter two models indicated a decreasing trend from 1997 to 2002, presumably related to mortality on longlines set for Patagonian toothfish Dissostichus eleginoides around the island, which peaked from 1996 to 1998. Grey-headed albatrosses exhibit greater variation in annual counts than other seabird species at Marion Island, possibly linked to interannual variation in breeding success because they are biennial breeders. However, breeding success alone was not significant in any of the models, presumably because it cannot capture the complexities of both population processes and environmental variation. Although all three models predicted the overall trends well, integrated population models, which can account for demographic processes, might be more appropriate to model long-term population trends. [ABSTRACT FROM AUTHOR]

The ubiquitin-proteasome system (UPS) plays a pivotal role in regulating protein homeostasis and cellular processes, including protein degradation, trafficking, DNA repair, and cell signaling. During cerebral ischemia, ischemic conditions profoundly disrupt UPS activity, leading to proteasomal dysfunction and the accumulation of abnormal proteins. This imbalance contributes to neuronal injury and cell death observed in ischemic stroke. The UPS is intricately linked to various signaling pathways crucial for neuronal survival, inflammation, and cellular stress response, such as NF-κB, TRIM, TRIP, JAK-STAT, PI3K/Akt, and ERK1/2. Alterations in the ubiquitination process can significantly impact the activation and regulation of these pathways, exacerbating ischemic brain injury. Therapeutic approaches targeting the UPS in cerebral ischemia aim to rebalance protein levels, reduce proteotoxic stress, and mitigate neuronal injury. Strategies include proteasome inhibition, targeting specific ubiquitin ligases and deubiquitinating enzymes, and modulating ubiquitination-mediated regulation of key signaling pathways implicated in ischemia-induced pathophysiology. Therefore, the present review discusses the molecular mechanisms underlying UPS dysfunction in ischemic stroke is crucial for developing effective therapeutic interventions. Modulating ubiquitination-mediated pathways through therapeutic interventions targeting specific UPS components holds significant promise for mitigating ischemic brain injury and promoting neuroprotection and functional recovery in patients with cerebral ischemia. [ABSTRACT FROM AUTHOR]

The innate immune system of mammals is formed by a complex web of interacting proteins, which together constitute the first barrier of entry for infectious pathogens. Genes from the E3-ubiquitin ligase tripartite motif (TRIM) family have been shown to play an important role in the innate immune system by restricting the activity of different retrovirus species. For example, TRIM5 and TRIM22 have both been associated with HIV restriction and are regarded as crucial parts of the antiretroviral machinery of mammals. Our analyses of positive selection corroborate the great significance of these genes for some groups of mammals. However, we also show that many species lack TRIM5 and TRIM22 altogether. By analyzing a large number of mammalian genomes, here we provide the first comprehensive view of the evolution of these genes in eutherians, showcasing that the pattern of accumulation of TRIM genes has been dissimilar across mammalian orders. Our data suggest that these differences are caused by the evolutionary plasticity of the immune system of eutherians, which have adapted to use different strategies to combat retrovirus infections. Altogether, our results provide insights into the dissimilar evolution of a representative family of restriction factors, highlighting an example of adaptive and idiosyncratic evolution in the innate immune system.

TRIM proteins are a family of innate immune factors that play diverse roles in innate immunity and protect the cell against viral and bacterial aggression. As part of this special issue on TRIM proteins, we will take advantage of our findings on TRIM69, which acts by reorganizing the microtubules (MTs) in a manner that is fundamentally antiviral, to more generally discuss how host–pathogen interactions that take place for the control of the MT network represent a crucial facet of the struggle that opposes viruses to their cell environment. In this context, we will present several other TRIM proteins that are known to interact with microtubules in situations other than viral infection, and we will discuss evidence that may suggest a possible contribution to viral control. Overall, the present review will highlight the importance that the control of the microtubule network bears in host–pathogen interactions. [ABSTRACT FROM AUTHOR]

One of the promising strategies for the improvement of the resistance characteristics and energy efficiency of a ship is trim optimization. Most of the studies conducted so far regarding trim optimization deal with unrestricted water. The effect of trim on the total resistance and its components for the KRISO Container Ship model in confined and shallow water is investigated using computational fluid dynamics. Numerical simulations of resistance tests with and without the free surface effects using two turbulence models are carried out for even keel and four trims in restricted water. A verification study is conducted for the total resistance, sinkage, and trim in terms of grid resolutions and time steps to assess the numerical uncertainty. The numerical results are validated against the experimental ones available in the literature. Performing the double body simulations enabled the analysis of the effect of trim on the resistance components. The numerical results pointed out that by adjusting the trim a reduction in the total resistance in confined and shallow water can be obtained. [ABSTRACT FROM AUTHOR]

Mitochondria are key orchestrators of antiviral responses that serve as platforms for the assembly and activation of innate immune-signaling complexes. In response to viral infection, mitochondria can be triggered to release immune-stimulatory molecules that can boost interferon production. These same molecules can be released by damaged mitochondria to induce pathogenic, antiviral-like immune responses in the absence of infection. This review explores how members of the tripartite motif-containing (TRIM) protein family, which are recognized for their roles in antiviral defense, regulate mitochondria-based innate immune activation. In antiviral defense, TRIMs are essential components of immune signal transduction pathways and function as directly acting viral restriction factors. TRIMs carry out conceptually similar activities when controlling immune activation related to mitochondria. First, they modulate immune-signaling pathways that can be activated by mitochondrial molecules. Second, they co-ordinate the direct removal of mitochondria and associated immune-activating factors through mitophagy. These insights broaden the scope of TRIM actions in innate immunity and may implicate TRIMs in diseases associated with mitochondria-derived inflammation. [ABSTRACT FROM AUTHOR]

Kun Wang,1 Wei Zhu,2 Wei Huang,3 Kangkang Huang,1 Huidan Luo,1 Lu Long,1 Bin Yi1 1Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan Province, People’s Republic of China; 2Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan Province, People’s Republic of China; 3Research Center of Carcinogenesis and Targeted Therapy, Xiangya Hospital, Central South University, Changsha, Hunan Province, People’s Republic of ChinaCorrespondence: Bin Yi, Tel +86-13707495781, Email xyyibin@163.comObjective: Ubiquitination is an important post-translational modification. However, the significance of the TRIM family of E3 ubiquitin ligases in head and neck squamous cell carcinoma (HNSCC) has not been determined. In this study, the roles of TRIM E3 ubiquitin ligases in lymphovascular invasion in head and neck squamous cell carcinoma (HNSCC) were evaluated.Materials and Methods: TRIM expression and related parameters were obtained from UbiBrowser2.0, UALCAN, TIMER, TISIDB, LinkedOmics, STRING, and GeneMANIA databases. Immunohistochemistry was used to confirm their expression.Results: TRIM2, TRIM11, TRIM28, and TRIM56 were upregulated in HNSCC with lymphovascular invasion. TRIM expression was strongly associated with immune infiltration, including key treatment targets, like PD-1 and CTL4. Co-expressed genes and possible ubiquitination substrates included tumor-related factors. The TRIMs had predicted roles in ubiquitination-related pathways and vital signaling pathways, eg, MAPK, PI3K-Akt, and JAK-STAT signaling pathways.Conclusion: Ubiquitination mediated by four TRIMs might be involved in the regulation of tumor immunity, laying the foundation for future studies of the roles of the TRIM family on the prediction and personalized medicine in HNSCC. The four TRIMs might exert oncogenic effects by promoting lymphovascular invasion in HNSCC.Keywords: ubiquitination, TRIM, head and neck squamous cell carcinoma, bioinformatic analysis, lymphovascular invasion

Heron colonies are dynamic components of wetlands. Therefore, their systematic monitoring is important for the management of both birds and wetlands. During the period 1988–2018, we counted breeding pairs of seven colonial breeding heron species at 65 colonies across 37 wetlands in Greece. We considered as annual variables of a population: (a) years since 1988, (b) Natura 2000 network inclusion, (c) protected area management authority overseeing, (d) wetland type (new or restored), and (e) new colonies (established after 2003). The Cattle Egret Bubulcus ibis and the Squacco Heron Ardeola ralloides had a positive breeding population trend. The Black-crowned Night Heron Nycticorax nycticorax, Little Egret Egretta garzetta, and Grey Heron Ardea cinerea had a negative trend, while the Purple Heron Ardea purpurea population was stable. The Great White Egret Ardea alba bred sporadically at only a few sites which precluded the evaluation of its population trend. The informative population variables differed among species, even of those at the same colony, which suggests trends are also affected by conditions at wintering grounds. The study highlights the need for the systematic monitoring of heron colonies and the protection of foraging/breeding areas in order to reverse the observed negative population trends.

Simple Summary: We studied the nesting population trends of the colonially nesting heron species in Greece from 1988 to 2018, aiming to identify drivers of these trends and thus inform colony/wetland conservation measures. Two species (Cattle Egret and Squacco Heron) had a positive trend, while three species (Black-crowned Night Heron, Little Egret and Grey Heron) had a negative trend. The Purple Heron presented a stable trend. Our results suggest that: (a) The Natura 2000 network and the operation of the protected areas Management Authorities have positively affected heron species nesting population trend or range expansion, (b) national wetland restoration efforts have facilitated the expansion of most heron species' breeding range via the establishment of new colonies, and (c) colonies located outside protected areas were—especially in the case of the Grey Heron—most likely to have a declining nesting population trend. The drivers behind the observed population trends differed among species, even among those sharing the same breeding sites. This suggests that the nesting population trends could be due to ecological changes at both the breeding and at the wintering sites. Our results emphasize the importance of continuing wetland restoration efforts, developing heron-friendly farming practices, and adopting a systematic nationwide survey of colonies. Heron colonies are dynamic components of wetlands. Therefore, their systematic monitoring is important for the management of both birds and wetlands. During the period 1988–2018, we counted breeding pairs of seven colonial breeding heron species at 65 colonies across 37 wetlands in Greece. We considered as annual variables of a population: (a) years since 1988, (b) Natura 2000 network inclusion, (c) protected area management authority overseeing, (d) wetland type (new or restored), and (e) new colonies (established after 2003). The Cattle Egret Bubulcus ibis and the Squacco Heron Ardeola ralloides had a positive breeding population trend. The Black-crowned Night Heron Nycticorax nycticorax, Little Egret Egretta garzetta, and Grey Heron Ardea cinerea had a negative trend, while the Purple Heron Ardea purpurea population was stable. The Great White Egret Ardea alba bred sporadically at only a few sites which precluded the evaluation of its population trend. The informative population variables differed among species, even of those at the same colony, which suggests trends are also affected by conditions at wintering grounds. The study highlights the need for the systematic monitoring of heron colonies and the protection of foraging/breeding areas in order to reverse the observed negative population trends. [ABSTRACT FROM AUTHOR]

The high speed coaxial helicopters with rigid blades will be the future development direction of rotor aircraft, to gain insights into the effect of of the advance ratio and lift offset on the aerodynamic characteristics of coaxial rigid rotor, a trim strategy was developed and the wind tunnel test was carried out in the FL-52 wind tunnel of AVIC Aerodynamics Research Institute to investigate the performance of coaxial rigid rotor. The rotor aerodynamic performance in hover and forward flight conditions and the influence of lift offset were studied. The results indicate that the trim strategy is reasonable, and the trim results are satisfactory. The trim errors of hub torque, total torque of rotors and lift offset are better than ±2 N·m, ± 0.5 N·m and ± 0.01 respectively. The efficiency of the upper rotor is greater than that of the lower rotor under torque balanced and unbalanced in hover. The efficiency of differential collective increases with the increase of coupled collective. In forward flight. The lift offset in forward flight can effectively improve the rotor aerodynamic efficiency at high forward ratio, but it is not significant at low forward ratio, increasing the lift offset will significantly increase the hub rolling moment of the upper and lower rotors. [ABSTRACT FROM AUTHOR]

This article presents the design, development and realization of miniaturized C-Band transmit receive integrated module (TRiM) for Earth observation satellite-04 (EOS-04) synthetic aperture radar (SAR) payload. Stateof-the-art low temperature co-fired ceramic (LTCC) technology is used for localized hermetic sealing of bare microwave monolithic integrated circuits (MMICs). A miniaturization of ~35% is achieved in this TRiM as compared to Radar Imaging Satellite-1 TR module, enabling >100 kg reduction in the overall EOS-04 SAR payload mass. The design of LTCC module is done using Ferro A6M-E and DuPont 951 based LTCC processes. Two such dual polarized LTCC TR modules along with in situ TR controller are housed inside a single TRiM housing. More than 13,000 MMICs are fabricated indigenously and utilized for the development of the TRiMs. About 350 such TRiMs have been mass produced through extensive participation of various Indian industries leading to the development and space qualification of several state-of-the-art processes. Measured transmit output power of >40 dBm, transmit gain >51 dB, receive gain >36 dB, noise figure <4.25 dB, phase error <4.5°, amplitude error <0.4 dB have been achieved for a 250 MHz wide bandwidth over 350 mass produced TRiMs. [ABSTRACT FROM AUTHOR]

The C-band Synthetic Aperture Radar (SAR) payload of Earth Observation Satellite (EOS-04), is a follow-on mission of Radar Imaging Satellite (RISAT-1). Though the overall configuration of the C-Band SAR payload has been retained from its predecessor, EOS-04 boasts of incorporating features, which target to keep up with the technological strides, and to improve the data quality. All the major modes of RISAT-1 are retained in EOS04 whereas fine resolution stripmap-2 mode, which was quad-polarization mode earlier, is upgraded to full-polarization mode. The payload also has better repeat cycle with improved systematic coverage mode. This article covers system level advancements, and radio frequency and digital electronics hardware, implemented in EOS-04. The satellite was launched on 14 February 2022 and since then all the major imaging modes are being operated successfully. [ABSTRACT FROM AUTHOR]

Quantifying biodiversity trends in economically developed countries, where depopulation, associated secondary succession, and climate warming are ongoing, provides insights for global biodiversity conservation in the 21st century. However, few studies have assessed the impacts of secondary succession and climate warming on species' population trends at a national scale. We estimated the population trends of common breeding bird species in Japan and examined the associations between the overall population trend and species traits with the nationwide bird count data on 47 species collected from 2009 to 2020. The overall population trend varied among species. Four species populations increased moderately, 18 were stable, and 11 declined moderately. Population trends for 13 species were uncertain. The difference in overall trends among the species was associated with their habitat group and temperature niche. Species with relatively low‐temperature niches experienced more pronounced declines. Multispecies indicators showed a moderate increase in forest specialists and moderate declines in forest generalists (species that use both forests and open habitats) and open‐habitat specialists. Forest generalists and open‐habitat specialists also declined more rapidly at sites with more abandoned farmland. All species groups showed an accelerated decline or decelerated increase after 2015. These results suggest that common breeding birds in Japan are facing deteriorating trends as a result of nationwide changes in land use and climate. Future land‐use planning and policies should consider the benefits of passive rewilding for forest specialists and active restoration measures (e.g., low‐intensive forestry and agriculture) for nonforest specialists to effectively conserve biodiversity in the era of human depopulation and climate warming. [ABSTRACT FROM AUTHOR]

This study discusses the inverted bow design on the combatant hull form. Changes in the shape of the stem angle and flare bow are used as analytical parameters to investigate the ship's performance. Ship resistance and motion will be predicted using the Computational Fluid Dynamics (CFD) approach using the Reynolds Averaged Navier Stokes (RANS) equation and the k-ε turbulence model. The volume of fluid (VOF) method is applied to simulate the change in the free surface between water and air using an overset mesh technique. The ship's movement is limited to sinkage and trim motions, so the movement's accuracy can be predicted. The results revealed that the inverted bow reduced the total resistance by 6.30%, whereas the trim and sinkage showed no significant changes. The breakdown of the reduction ratio showed that friction resistance components were reduced by 10.62%, wave resistance by 44.05%, and viscous-pressure resistance by 45.33%. This highlights the effectiveness of an inverted bow in optimizing wave and viscous pressure, enhancing overall ship performance.

Purpose: The sandy environment is one of the typical environments in which helicopters operate. Air-sand two-phase flow in sandy environments may be an important factor affecting flight safety. Taking a typical example, this paper aims to investigate the aerodynamic and rotor trim characteristics of the UH-60 helicopter in sandy environments. Design/methodology/approach: A computational study is conducted to simulate the air-sand flow over airfoils based on the Euler–Lagrange framework. The simulation uses the S-A turbulence model and the two-way momentum coupling methodology. Additionally, the trim characteristics of the UH-60 rotor are calculated based on the isolated rotor trim algorithm. Findings: The simulation results show that air-sand flow significantly affects the aerodynamic characteristics of the SC1095 airfoil and the SC1094R8 airfoil. The presence of sand particles leads to a decrease in lift and an increase in drag. The calculation results of the UH-60 helicopter rotor indicate that the thrust decreases and the torque increases in the sandy environment. To maintain a steady forward flight in sandy environments, it is necessary to increase the collective pitch and the longitudinal cyclic pitch. Originality/value: In this paper, the aerodynamic characteristics of airfoils and the trim characteristics in the air-sand flow of the UH-60 helicopter are discussed, which might be a new view to analyse the impact of sandy environments on helicopter safety and manoeuvring. [ABSTRACT FROM AUTHOR]

Simple Summary: Long terminal repeat (LTR) retrotransposons and non-LTR retrotransposons are two major repetitive components of eukaryotic genomes. Short intersperse elements (SINEs) are non-autonomous non-LTR retrotransposons with a sequence similar to small RNAs such as tRNA and 5S rRNA. Cassandra is a non-autonomous LTR retrotransposon with a 5S rRNA-like sequence in its LTRs. This observation led me to investigate the presence of non-autonomous LTR retrotransposons containing other small RNA sequences in their LTRs. Here, I discover and describe non-autonomous LTR retrotransposons Helenus and Ajax, with LTR regions of respective tRNA and 5S rRNA origin. Helenus and Ajax are likely mobilized by autonomous LTR retrotransposons. Helenus or Ajax are unlikely to encode a functional RNA. The finding of Helenus and Ajax confirms that non-autonomous LTR retrotransposons can be a source of small RNA-like interspersed sequences in the eukaryotic genomes. An understanding of their biology could contribute to the more precise prediction of small RNA genes and cellular RNA components as well as to the understanding of their evolutionary impacts. Terminal repeat retrotransposons in miniature (TRIMs) are short non-autonomous long terminal repeat (LTR) retrotransposons found from various eukaryotes. Cassandra is a unique TRIM lineage which contains a 5S rRNA-derived sequence in its LTRs. Here, two new groups of TRIMs, designated Helenus and Ajax, are reported based on bioinformatics analysis and the usage of Repbase. Helenus is found from fungi, animals, and plants, and its LTRs contain a tRNA-like sequence. It includes two LTRs and between them, a primer-binding site (PBS) and polypurine tract (PPT) exist. Fungal and plant Helenus generate 5 bp target site duplications (TSDs) upon integration, while animal Helenus generates 4 bp TSDs. Ajax includes a 5S rRNA-derived sequence in its LTR and is found from two nemertean genomes. Ajax generates 5 bp TSDs upon integration. These results suggest that despite their unique promoters, Helenus and Ajax are TRIMs whose transposition is dependent on autonomous LTR retrotransposon. These TRIMs can originate through an insertion of SINE in an LTR of TRIM. The discovery of Helenus and Ajax suggests the presence of TRIMs with a promoter for RNA polymerase III derived from a small RNA gene, which is here collectively termed TRIMp3. [ABSTRACT FROM AUTHOR]

The microtubule network is formed from polymerised tubulin subunits and associating proteins, which govern microtubule dynamics and a diverse array of functions. To identify novel microtubule-binding proteins, we have developed an unbiased biochemical assay, which relies on the selective extraction of cytosolic proteins from U2OS cells, while leaving behind the microtubule network. Candidate proteins are linked to microtubules by their sensitivities to the depolymerising drug nocodazole or the microtubule-stabilising drug taxol, which is quantitated by mass spectrometry. Our approach is benchmarked by co-segregation of tubulin and previously established microtubule-binding proteins. We then identify several novel candidate microtubule-binding proteins, from which we have selected the ubiquitin E3 ligase tripartite motif-containing protein 3 (TRIM3) for further characterisation. We map TRIM3 microtubule binding to its C-terminal NHL-repeat region. We show that TRIM3 is required for the accumulation of acetylated tubulin, following treatment with taxol. Furthermore, loss of TRIM3 partially recapitulates the reduction in nocodazole-resistant microtubules characteristic of a-tubulin acetyltransferase 1 (ATAT1) depletion. These results can be explained by a decrease in ATAT1 following depletion of TRIM3 that is independent of transcription. [ABSTRACT FROM AUTHOR]

This study discusses the inverted bow design on the combatant hull form. Changes in the shape of the stem angle and flare bow are used as analytical parameters to investigate the ship's performance. Ship resistance and motion will be predicted using the Computational Fluid Dynamics (CFD) approach using the Reynolds Averaged Navier Stokes (RANS) equation and the k-e turbulence model. The volume of fluid (VOF) method is applied to simulate the change in the free surface between water and air using an overset mesh technique. The ship's movement is limited to sinkage and trim motions, so the movement's accuracy can be predicted. The results revealed that the inverted bow reduced the total resistance by 6.30%, whereas the trim and sinkage showed no significant changes. The breakdown of the reduction ratio showed that friction resistance components were reduced by 10.62%, wave resistance by 44.05%, and viscous-pressure resistance by 45.33%. This highlights the effectiveness of an inverted bow in optimizing wave and viscous pressure, enhancing overall ship performance. [ABSTRACT FROM AUTHOR]

One of the promising strategies for the improvement of the resistance characteristics and energy efficiency of a ship is trim optimization. Most of the studies conducted so far regarding trim optimization deal with unrestricted water. The effect of trim on the total resistance and its components for the KRISO Container Ship model in confined and shallow water is investigated using computational fluid dynamics. Numerical simulations of resistance tests with and without the free surface effects using two turbulence models are carried out for even keel and four trims in restricted water. A verification study is conducted for the total resistance, sinkage, and trim in terms of grid resolutions and time steps to assess the numerical uncertainty. The numerical results are validated against the experimental ones available in the literature. Performing the double body simulations enabled the analysis of the effect of trim on the resistance components. The numerical results pointed out that by adjusting the trim a reduction in the total resistance in confined and shallow water can be obtained.

The tripartite motif (TRIM) protein family members have been implicated in a multitude of physiologies and pathologies in different tissues. With diverse functions in cellular processes including regulation of signaling pathways, protein degradation, and transcriptional control, the impact of TRIM dysregulation can be multifaceted and complex. Here, we focus on the cellular and molecular roles of TRIMs identified in the brain in the context of a selection of pathologies including cancer and neurodegeneration. By examining each disease in parallel with described roles in brain development, we aim to highlight fundamental common mechanisms employed by TRIM proteins and identify opportunities for therapeutic intervention. [ABSTRACT FROM AUTHOR]

Hydrodynamic performance is an essential factor in the design of a watercraft, and the navigation scenario determines the complexity of its operation. This study aims to identify the effect of speed and length on the hydrodynamic behavior of a semi-planing watercraft in shallow waters. A computational fluid dynamics tool was employed to predict the trim, heave, and resistance parameters of two different hulls: a base hull and a craft with an increased hull length. The two hulls had similar hydrodynamic characteristics. The effects of speed and hull length on these predicted parameters obtained for the two hulls were compared. The results showed a low resistance uncertainty and a reduction in dynamic trim for longer hull lengths. These findings highlight the importance of considering balance and dynamic trim in designing shallow-draft watercrafts to ensure an optimal performance in specific conditions, such as rivers with depth restrictions. [ABSTRACT FROM AUTHOR]

Researchers commonly conceptualize forgiveness as a rich complex of psychological changes involving attitudes, emotions, and behaviors. Psychometric work with the measures developed to capture this conceptual richness, however, often points to a simpler picture of the psychological dimensions in which forgiveness takes place. In an effort to better unite forgiveness theory and measurement, we evaluate several psychometric models for common measures of forgiveness. In doing so, we study people from the United States and Japan to understand forgiveness in both nonclose and close relationships. In addition, we assess the predictive utility of these models for several behavioral outcomes that traditionally have been linked to forgiveness motives. Finally, we use the methods of item response theory, which place person abilities and item responses on the same metric and, thus, help us draw psychological inferences from the ordering of item difficulties. Our results highlight models based on correlated factors models and bifactor (S-1) models. The bifactor (S-1) model evinced particular utility: Its general factor consistently predicts variation in relevant criterion measures, including 4 different experimental economic games (when played with a transgressor), and also suffuses a second self-report measure of forgiveness. Moreover, the general factor of the bifactor (S-1) model identifies a single psychological dimension that runs from hostility to friendliness while also pointing to other sources of variance that may be conceived of as method factors. Taken together, these results suggest that forgiveness can be usefully conceptualized as prosocial change along a single attitudinal continuum that ranges from hostility to friendliness. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Membrane integrity is essential for cellular survival and function. The spectrum of mechanisms protecting cellular and intracellular membranes is not fully known. Our recent work has uncovered a cellular system termed MERIT for lysosomal membrane repair, removal and replacement. Specifically, lysosomal membrane damage induces, in succession, ESCRT-dependent membrane repair, macroautophagy/autophagy-dominant removal of damaged lysosomes, and initiation of lysosomal biogenesis via transcriptional programs. The MERIT system is governed by galectins, a family of cytosolically synthesized lectins recognizing β-galactoside glycans. We found in this study that LGALS3 (galectin 3) detects membrane damage by detecting exposed lumenal glycosyl groups, recruits and organizes ESCRT components PDCD6IP/ALIX, CHMP4A, and CHMPB at damaged sites on the lysosomes, and facilitates ESCRT-driven repair of lysosomal membrane. At later stages, LGALS3 cooperates with TRIM16, an autophagy receptor-regulator, to engage autophagy machinery in removal of excessively damaged lysosomes. In the absence of LGALS3, repair and autophagy are less efficient, whereas TFEB nuclear translocation increases to compensate lysosomal deficiency via de novo lysosomal biogenesis. The MERIT system protects endomembrane integrity against a broad spectrum of agents damaging the endolysosomal network including lysosomotropic drugs, Mycobacterium tuberculosis, or neurotoxic MAPT/tau.AbbreviationsAMPK: AMP-activated protein kinase; APEX2: engineered ascorbate peroxidase 2; ATG13: autophagy related 13; ATG16L1: autophagy related 16 like 1; BMMs: bone marrow-derived macrophages; ESCRT: endosomal sorting complexes required for transport; GPN: glycyl-L-phenylalanine 2-naphthylamide; LLOMe: L-leucyl-L-leucine methyl ester; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MERIT: membrane repair, removal and replacement; MTOR: mechanistic target of rapamycin kinase; TFEB: transcription factor EB; TFRC: transferrin receptor; TRIM16: tripartite motif-containing 16.

Mitochondria are the center for energy production, cell fate determination and synthesis of essential biomolecules in cells. Hence, mitochondrial quality control mechanisms are essential for cellular health. Failure of these control mechanisms may lead to damaged mitochondria that represent a threat to cell survival. Mitophagy is a selective autophagy process that removes damaged mitochondria through lysosomal degradation. The triggering of mitophagy can be either ubiquitin dependent or ubiquitin independent. Ubiquitin-dependent mitophagy relies on ubiquitin as a signal on the surface of dysfunctional mitochondria. PRKN/PARKIN is the ubiquitin E3 ligase of the well described PINK1-PRKN-dependent mitophagy. However, other ubiquitin-dependent mitophagy pathways that are independent of PRKN are emerging, but little is known about which ubiquitin E3 ligases are implicated. We shall here discuss our recent identification of the ubiquitin E3 ligase TRIM27 (tripartite motif containing 27) as a player in PINK1-PRKN-independent mitophagy. We will focus on the concerted action of TRIM27, the autophagy receptor SQSTM1/p62 and TBK1 (TANK binding kinase 1), which leads to mitochondrial clustering and enhanced mitophagy. We propose a model where a TRIM27-SQSTM1/p62-TBK1 pathway acts as an alternative or compensatory pathway for the PINK1-PRKN pathway to induce ubiquitin-dependent mitophagy.

Most seaplanes used for aircraft operations in territorial waters are classified into three main types, namely floatplanes, flying boats, and amphibians. Among these, the floatplane stands out as it replaced its landing gear with two floating pontoons, known as the catamaran floater, on which the fuselage rests. Therefore, this research presented a data article on resistance testing to predict force and moment along the x, y, and z axes for a 1:10 scale model of the catamaran floater. Test data encompassed variations in trim angles 0°, −1°, and −2°, and speed ranging from 1 to 6 m/s. The results of the resistance testing are presented in the form of descriptive statistics and shown through two graphs. The first graph described the relationship between the catamaran floater's speed and the corresponding force generated. The second graph illustrated the correlation between the catamaran floater's speed and moment generated.

The tripartite motif (TRIM) protein family members have been implicated in a multitude of physiologies and pathologies in different tissues. With diverse functions in cellular processes including regulation of signaling pathways, protein degradation, and transcriptional control, the impact of TRIM dysregulation can be multifaceted and complex. Here, we focus on the cellular and molecular roles of TRIMs identified in the brain in the context of a selection of pathologies including cancer and neurodegeneration. By examining each disease in parallel with described roles in brain development, we aim to highlight fundamental common mechanisms employed by TRIM proteins and identify opportunities for therapeutic intervention.

Fuel is the largest contributor to the operating cost of airlines. It has always been a concern for researchers to come up with ways to reduce fuel consumption and make the aviation industry more environmentally friendly. The challenge here is to reduce the drag in order to reduce fuel consumption. This research work focuses on the impact of the center of gravity on the total drag of a B747-400 aircraft, with the aim of reducing the amount of fuel consumed and increasing its range. MATLAB code was used to assess the trim conditions at the different center of gravity locations, and the stability and control derivatives were evaluated from the results using Microsoft Excel. The study concludes that as the center of gravity moves aft within the permissible range, the total drag of the aircraft decreases. The optimal center of gravity location was found at 39.5 % of the Mean Aerodynamic Chord (MAC), corresponding to a maximum range of 13,930 km. This research work is important as it provides insight into the relationship between the center of gravity and total drag, and how it affects the fuel consumption and range of an aircraft. By understanding this relationship, engineers can design aircraft with more efficient fuel consumption, thus reducing the environmental impact of the aviation industry.

The investigation of PVC surface characteristics involved the utilization of Monte Carlo simulation software, TRIM, to replicate the interaction between ion beams and the PVC surface. TRIM is a widely employed tool for examining surface structure. The analysis centered on the interactions between PVC surfaces and ions of hydrogen, helium, argon, and krypton. The ion beam irradiation was carried out at varying angles 0°, 15°, 30°, 45°, 60°, and 75° relative to the sample's surface normal, and it encompassed two distinct incident ion energies 1 keV and 1 MeV. The interplay between ions and the PVC surface can result in diverse processes, including sputtering, emission, and ionization, contingent upon the mass, incident energy, and angle of incidence of the ions. The calculation of stopping power (both nuclear and electronic) and the range of projectiles can also be determined using the same set of incident ions (H, He, Ar, and Kr) but within different energy spectrums (from 10 eV to 10 MeV). The stopping range is contingent on the incident energy and mass of each incident ion, a crucial factor in the process of implantation. This procedure finds applications in doping semiconductors or other materials, with potential uses in catalysis, gas sensing, and various chemical applications.

In this paper, a numerical assessment of the effect of shallow water on the total resistance of the solar catamaran SolarCat is carried out using computational fluid dynamics within the software package STAR–CCM+. The unsteady viscous fluid flow was modelled based on the Reynolds-averaged Navier–Stokes (RANS) equations with the application of the k − ω SST ( k − ω Shear Stress Transport) turbulence model. The RANS equations were discretized by the finite volume method, and the position of the free surface is determined by the volume of fluid method. In shallow water conditions, a mesh morphing algorithm is applied. Numerical simulations were carried out for the deep water and limited depths corresponding to h / T = 7. 6 , h / T = 4 , and h / T = 2 at two speeds. The verification study was carried out and the total numerical uncertainty was calculated for the total resistance and sinkage of the catamaran. A detailed analysis of the flow around the catamaran was carried out. [ABSTRACT FROM AUTHOR]

Exosomes have the potential to be the future of personalized diagnostics and therapy. They are nano-sized particles between 30 and 100 nm flowing in the extracellular milieu, where they mediate cell–cell communication and participate in immune system regulation. Tumor-derived exosomes (TDEs) secreted from different types of cancer cells are the key regulators of the tumor microenvironment. With their immune suppressive cargo, TDEs prevent the antitumor immune response, leading to reduced effectiveness of cancer treatment by promoting a pro-tumorigenic microenvironment. Involved signaling pathways take part in the regulation of tumor proliferation, differentiation, apoptosis, and angiogenesis. Signal transducers and activators of transcription factors (STATs) and Janus kinase (JAK) signaling pathways are crucial in malignancies and autoimmune diseases alike, and their potential to be manipulated is currently the focus of interest. In this review, we aim to discuss exosomes, TDEs, and the JAK/STAT pathways, along with mediators like interleukins, tripartite motif proteins, and interferons. [ABSTRACT FROM AUTHOR]

IMO presented the standard for ship's manoeuvrability which every ship is recommended to satisfy. Although it specifies a full load and even keel condition as the condition at which the standard applies, practically, ships are operated under various loading conditions of cargo. From this viewpoint, the authors have conducted manoeuvring tests of a container ship under five loading conditions with different combinations of the draft and trim, and one of the authors established the manoeuvring mathematical model of the ship for each condition so far. This study focuses on the course-keeping performance of the same ship under these loading conditions under wind disturbance. It is the aim of this study to discuss both the influences of loading condition and wind condition simultaneously on the check helm and attitude of the ship while maintaining the target course. For this purpose, the arrangement of containers and their weight distribution were designed as exact as possible. For example, the ship with a trim by bow, which is commonly preferred for fuel efficiency, needs to have a larger check helm for course keeping, especially under the condition of wind disturbance diagonally from behind. This kind of knowledge would be useful for safe navigation. [ABSTRACT FROM AUTHOR]

Bats have received increasing attention because of some unique biological features they possess. TRIM is a large family of proteins that participate in diverse cellular functions, such as antiviral immunity, DNA damage repair, tumor suppression, and aging. These functional areas appear to be highly consistent with the special characteristics of bats, such as tolerance to viruses and DNA damage generated in flight, low cancer incidence, and longevity. However, there is still a lack of systematic study of the TRIM family in bats. Here, we explored the TRIM family of bats using the genomes of 16 representative species. The results showed that the bat TRIM family contains 70 members, with 24 under positive selection and 7 duplicated. Additional transcriptomic analysis revealed the tissue-specific expressions of TRIM9, 46, 54, 55, 63, and 72. Additionally, following interferon or viral stimulation, TRIM orthologs associated with antiviral immunity reported in humans were also upregulated in bat cells. The present study systematically analyzed the composition, evolution, and expression of bat TRIM genes. It may provide a theoretical basis for studies of bat TRIM in the fields of antiviral immunity, longevity, and tolerance to DNA damage. [ABSTRACT FROM AUTHOR]

A 23 factorial design experiment was conducted to study the influence of pre-heating temperature (HT) for manufacturing sample, bonding temperature (BT) onto rheometer, and trimming state (Trim) of the sample on complex shear modulus (G*) and phase angle (δ) using a dynamic shear rheometer on unmodified bitumen of types 50/70, 70/100, and two 160/220 from various sources. In addition, the black diagram and 2S2P1D model were used to evaluate the viscoelastic properties of bitumens. Findings show that the G* is more sensitive to the changes than the δ. Additionally, it was found that the 8 mm parallel plate diameter had a higher sensitivity to the trimming state than the 25 mm. The tested factor HT generally did not have a statistically significant impact on the results of the tested materials, except for 160/220_I. At practically all the temperatures tested for 50/70 and 160/220_II, the G* dropped by increasing the factor BT from a lower to a higher value. The Trim:BT interaction has the greatest impact on all materials and temperatures on G*, except for 160/220 at lower temperatures. However, in the case of δ, the Trim:BT interaction has the most significant effects for 70/100 and 160/220_II. The black diagrams show no discernible differences, which may be a result of the limited range of changes made to the variables. [ABSTRACT FROM AUTHOR]

Objectives: This psychobiography focuses on the advocacy work of Natasha Keating, a trans woman incarcerated in two male prisons in Australia between 2000 and 2007. Incarcerated trans women are a vulnerable group who experience high levels of victimization and discrimination. However, Natasha advocated for her rights while incarcerated and this advocacy contributed to substantial changes in the carceral system. This psychobiography uses psychological understandings of resilience as well as the Transgender Resilience Intervention Model (TRIM) to investigate the factors that enabled this advocacy. Method: Data consisted of an archive of letters written by Natasha and interviews with individuals who knew her well. This psychobiography was guided by du Plessis' (2017) 12‐step approach and included the identification of psychological saliencies and the construction of a Multilayered Chronological Chart. Results: Natasha's life is presented in four chapters, with each chapter including a discussion of resilience based on the TRIM. Conclusions: The TRIM suggests that during incarceration, Natasha was able to access more group‐level resilience factors than at any other time in her life. This, combined with individual resilience factors, enabled her advocacy. This finding has implications for advocacy in general as it highlights the importance of both individual‐ and group‐level factors in enabling individuals to effectively advocate for change in their environments. [ABSTRACT FROM AUTHOR]

In the independent works by Kalgin and Idrisova and by Beierle, Leander and Perrin, it was observed that the Gold APN functions over F 2 5 give rise to a quadratic APN function in dimension 6 having maximum possible linearity of 2 5 (that is, minimum possible nonlinearity 2 4 ). In this article, we show that the case of n ≤ 5 is quite special in the sense that Gold APN functions in dimension n > 5 cannot be extended to quadratic APN functions in dimension n + 1 having maximum possible linearity. In the second part of this work, we show that this is also the case for APN functions of the form x ↦ x 3 + μ (x) with μ being a quadratic Boolean function. [ABSTRACT FROM AUTHOR]

Hao Su,&ast; Yueheng Tang,&ast; Kexin Nie, Zhi Wang, Hongzhan Wang, Hui Dong, Gang Chen Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Gang ChenDepartment of Integration Traditional Chinese Medicine and Western Medicine, TongJi Hospital, Huazhong University of Science and Technology, 1095Jiefang Avenue, Wuhan, Hubei Province, 430030, People’s Republic of China, Email dragonchengang@sina.comBackground: Hepatocellular carcinoma (HCC) is one of the most common and mortality types of malignant tumors in the world. The Tripartite-Motif (TRIM) protein family consists of more than 80 proteins with E3 ubiquitin ligase activity. Increasing studies have found that TRIM family proteins play an extremely important role in the occurrence and development of tumors. However, the expression and prognostic values of TRIMs in HCC have not been clarified.Methods: We used bioinformatic methods to explore the potential function of TRIM family genes in the HCC. Web servers ONCOMINE, UALCAN, GEPIA, cBioPortal, STRING, DAVID 6.8 and TIMER were used in this research.Results: We screened TRIM1-76 and found the expressions of TRIM6, TRIM11, TRIM16, TRIM18(MID1), TRIM24, TRIM28, TRIM31, TRIM37, TRIM45, TRIM52, TRIM59, TRIM66 were significantly changed in HCC. Among them, TRIM24, TRIM28, TRIM37, TRIM45 and TRIM59 had significant effects on pathological stages, overall survival and disease free survival. Functions of these genes are primarily related to transcriptional misregulation in cancer, p53 signaling pathway, alcoholism and viral carcinogenesis, FoxO signal pathway, PI3K-AKT pathway, cell cycle, microRNAs in cancer. Our results showed the significant correlation between TRIMs expression and infiltration of innate immune cells (macrophages, neutrophils, and dendritic cells).Conclusion: Our result provides novel insights into the function of TRIM family genes, which may be used as potential references for drug targets and accurate survival predictions in patients with HCC.Keywords: hepatocellular carcinoma, bioinformatics analysis, TRIM, survival, tumor immunology

A planing hull is a high-speed craft with relatively complex hydrodynamic characteristics. An increase in speed can induce a significant change in trim angle with an increment in ship drag. One solution to reduce ship resistance is to use an interceptor. This research aimed to analyze the hydrodynamics of a planing hull vessel by applying an interceptor. The fundamental aspects reviewed included the analysis of drag, trim, heave, and lift force. The interceptor would be investigated on the basis of its integrated position at its height. This research also used the computational fluid dynamic (CFD) method in calm water conditions. All simulations were conducted with the same mesh structure, which allowed the performance evaluation of the interceptor in calculating turbulent air–water flow around the ship. Numerical calculations used the Reynolds-averaged Navier–Stokes (RANS) equation with the k–ε turbulence model to predict the turbulent flow. The vertical motion of the ship was modeled using dynamic fluid–body interaction (DFBI) in the fluid domain through an overset mesh technique. The numerical approach was compared with the experimental test results of Park et al. to ensure the accuracy of the test results. The interceptor was designed at the transition phase, which showed the highest trim angle followed by high drag. The interceptor would experience negative trim at high speeds; thus, it was not recommended. The research results indicated that the most effective use of the interceptor was at Froude number 0.87 close to the chine position with a height of 100%. This interceptor could reduce a maximum of 57% drag, 17% heave, 8.48% trim, and 0.12% lift force. The interceptor could increase excessive drag and trim at Froude numbers over 1.16. The interceptor proved to be remarkably useful in trim control and ship drag reduction, but selecting the wrong dimensions and positions of the interceptor could endanger the ship. This simulation was performed on Aragon-2; thus, the interceptor performance may possibly change if a different hull geometry is used.

Hydrodynamic performance is an essential factor in the design of a watercraft, and the navigation scenario determines the complexity of its operation. This study aims to identify the effect of speed and length on the hydrodynamic behavior of a semi-planing watercraft in shallow waters. A computational fluid dynamics tool was employed to predict the trim, heave, and resistance parameters of two different hulls: a base hull and a craft with an increased hull length. The two hulls had similar hydrodynamic characteristics. The effects of speed and hull length on these predicted parameters obtained for the two hulls were compared. The results showed a low resistance uncertainty and a reduction in dynamic trim for longer hull lengths. These findings highlight the importance of considering balance and dynamic trim in designing shallow-draft watercrafts to ensure an optimal performance in specific conditions, such as rivers with depth restrictions.

In this paper, a numerical assessment of the effect of shallow water on the total resistance of the solar catamaran SolarCat is carried out using computational fluid dynamics within the software package STAR–CCM+. The unsteady viscous fluid flow was modelled based on the Reynolds-averaged Navier–Stokes (RANS) equations with the application of the k−ω SST (k−ω Shear Stress Transport) turbulence model. The RANS equations were discretized by the finite volume method, and the position of the free surface is determined by the volume of fluid method. In shallow water conditions, a mesh morphing algorithm is applied. Numerical simulations were carried out for the deep water and limited depths corresponding to h/T=7.6, h/T=4, and h/T=2 at two speeds. The verification study was carried out and the total numerical uncertainty was calculated for the total resistance and sinkage of the catamaran. A detailed analysis of the flow around the catamaran was carried out.

Background: As significant components of E3 ligases, the tripartite motif (TRIM) proteins participate in various biological processes and facilitate the development of several diseases. Nevertheless, the correlations of TIRMs with hepatitis B virus (HBV)-positive hepatoma carcinoma (HCC) are not well elaborated. Methods: The expression profile of TRIM genes in HBV-associated HCC and related clinical information were extracted from the Cancer Genome Atla (TCGA) database and the International Cancer Genome Consortium (ICGC) database. Dependent on the ConsensusPathDB and STRING databases, the gene ontology, Reactome pathways, and protein-protein interaction were assessed. Relied on TIMER 2.0 database, the relationship of the TRIMs with immune infiltration was investigated. Using multivariate analysis and Kaplan Meier analysis, the association between TRIM genes and the prognostic value was examined. Results: A total of 17 TRIM genes, including TRIM16, TRIM17, and TRIM31 with fold change no less than 1.5, were discovered to upregulate in HBV-associated HCC in both TCGA and ICGC cohorts. Relied on gene enrichment analysis, the identified TRIMs were observed to not only be related to the interferon and cytokine signaling but also linked to the adaptive immune system. Particularly, the co-expression patterns of identified TRIMs with other E3 ligase genes and many innate immune genes that are associated with Tolllike receptor signaling, apoptosis, and SUMOylation. Besides, some of identified TRIM expressions were also linked to the infiltration levels of T cells and B cells. Additionally, several TRIM genes were associated with various clinical factors and relevant to the poor survival of HBV-associated HCC. Conclusion: Our findings could deepen our understanding of TRIMs and their correlations with HBV-associated HCC. Furthermore, some of these TRIMs may be utilized as new prognostic markers of HBV-related HCC prognosis, or act as potential molecular targets for the disease. [ABSTRACT FROM AUTHOR]

The leak tightness of seal assemblies in pipeline valves is analyzed. It is shown that the leak tightness of sealing elements does not depend on the area of contact surfaces but rather on the presence of a continuous narrow strip formed by individual contact areas. Witness specimens prepared using the proposed technology for creating a tight space between the sealing surfaces were tested for leak tightness. [ABSTRACT FROM AUTHOR]

A planing hull is a high-speed craft with relatively complex hydrodynamic characteristics. An increase in speed can induce a significant change in trim angle with an increment in ship drag. One solution to reduce ship resistance is to use an interceptor. This research aimed to analyze the hydrodynamics of a planing hull vessel by applying an interceptor. The fundamental aspects reviewed included the analysis of drag, trim, heave, and lift force. The interceptor would be investigated on the basis of its integrated position at its height. This research also used the computational fluid dynamic (CFD) method in calm water conditions. All simulations were conducted with the same mesh structure, which allowed the performance evaluation of the interceptor in calculating turbulent air-water flow around the ship. Numerical calculations used the Reynolds-averaged Navier-Stokes (RANS) equation with the k-e turbulence model to predict the turbulent flow. The vertical motion of the ship was modeled using dynamic fluid-body interaction (DFBI) in the fluid domain through an overset mesh technique. The numerical approach was compared with the experimental test results of Park et al. to ensure the accuracy of the test results. The interceptor was designed at the transition phase, which showed the highest trim angle followed by high drag. The interceptor would experience negative trim at high speeds; thus, it was not recommended. The research results indicated that the most effective use of the interceptor was at Froude number 0.87 close to the chine position with a height of 100%. This interceptor could reduce a maximum of 57% drag, 17% heave, 8.48% trim, and 0.12% lift force. The interceptor could increase excessive drag and trim at Froude numbers over 1.16. The interceptor proved to be remarkably useful in trim control and ship drag reduction, but selecting the wrong dimensions and positions of the interceptor could endanger the ship. This simulation was performed on Aragon-2; thus, the interceptor performance may possibly change if a different hull geometry is used. [ABSTRACT FROM AUTHOR]