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24 results on '"Trimboli, Anthony J."'

1. Data from Stromal p53 Regulates Breast Cancer Development, the Immune Landscape, and Survival in an Oncogene-Specific Manner

Author

Wu, Jinghai, primary, Liu, Xin, primary, Reeser, Julie A. Wallace, primary, Trimboli, Anthony J., primary, Pécot, Thierry, primary, Sizemore, Gina M., primary, Naidu, Shan K., primary, Fernandez, Soledad A., primary, Yu, Lianbo, primary, Hallett, Michael, primary, Park, Morag, primary, Leone, Gustavo W., primary, Hildreth, Blake E., primary, and Ostrowski, Michael C., primary

Published
2023
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2. Supplementary Data from Stromal p53 Regulates Breast Cancer Development, the Immune Landscape, and Survival in an Oncogene-Specific Manner

Author

Wu, Jinghai, primary, Liu, Xin, primary, Reeser, Julie A. Wallace, primary, Trimboli, Anthony J., primary, Pécot, Thierry, primary, Sizemore, Gina M., primary, Naidu, Shan K., primary, Fernandez, Soledad A., primary, Yu, Lianbo, primary, Hallett, Michael, primary, Park, Morag, primary, Leone, Gustavo W., primary, Hildreth, Blake E., primary, and Ostrowski, Michael C., primary

Published
2023
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6. Stromal p53 Regulates Breast Cancer Development, the Immune Landscape, and Survival in an Oncogene-Specific Manner

Author

Wu, Jinghai, primary, Liu, Xin, additional, Reeser, Julie A. Wallace, additional, Trimboli, Anthony J., additional, Pécot, Thierry, additional, Sizemore, Gina M., additional, Naidu, Shan K., additional, Fernandez, Soledad A., additional, Yu, Lianbo, additional, Hallett, Michael, additional, Park, Morag, additional, Leone, Gustavo W., additional, Hildreth, Blake E., additional, and Ostrowski, Michael C., additional

Published
2022
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7. Evidence for a stepwise program of extrathymic T cell development within the human tonsil

Author

McClory, Susan, Hughes, Tiffany, Freud, Aharon G., Briercheck, Edward L., Martin, Chelsea, Trimboli, Anthony J., Yu, Jianhua, Zhang, Xiaoli, Leone, Gustavo, Nuovo, Gerard, and Caligiuri, Michael A.

Subjects
T cells -- Growth -- Genetic aspects, Gene expression -- Research, Tonsils -- Genetic aspects, Thymus -- Growth -- Genetic aspects, Cell differentiation -- Genetic aspects, Company growth, Health care industry
Abstract

The development of a broad repertoire of T cells, which is essential for effective immune function, occurs in the thymus. Although some data suggest that T cell development can occur extrathymically, many researchers remain skeptical that extrathymic T cell development has an important role in generating the T cell repertoire in healthy individuals. However, it may be important in the setting of poor thymic function or congenital deficit and in the context of autoimmunity, cancer, or regenerative medicine. Here, we report evidence that a stepwise program of T cell development occurs within the human tonsil. We identified 5 tonsillar T cell developmental intermediates: (a) CD34+CD[38.sup.dim]Lin- cells, which resemble multipotent progenitors in the bone marrow and thymus; (b) more mature CD34+CD[38.sup.bright]Lin- cells; (c) CD34+CD1a+CD11c- cells, which resemble committed T cell lineage precursors in the thymus; (d) CD34-CD1a+CD3-CD11c- cells, which resemble CD4+CD8+ double-positive T cells in the thymus; and (e) CD34-CD1a+CD3+CD11c- cells. The phenotype of each subset closely resembled that of its thymic counterpart. The last 4 populations expressed RAG1 and PTCRA, genes required for TCR rearrangement, and all 5 subsets were capable of ex vivo T cell differentiation. TdT+ cells found within the tonsillar fibrous scaffold expressed CD34 and/or CD1a, indicating that this distinct anatomic region contributes to pre-T cell development, as does the subcapsular region of the thymus. Thus, we provide evidence of a role for the human tonsil in a comprehensive program of extrathymic T cell development., Introduction The development of human T cells can be divided into discrete stages, ranging from that for multipotent progenitors to that for naive T cells. The expression of CD4 and/or [...]

Published
2012
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8. Pten in stromal fibroblasts suppresses mammary epithelial tumours

Author

Trimboli, Anthony J., Cantemir-Stone, Carmen Z., Li, Fu, Wallace, Julie A., Merchant, Anand, Creasap, Nicholas, Thompson, John C., Caserta, Enrico, Wang, Hui, Chong, Jean-Leon, Naidu, Shan, Wei, Guo, Sharma, Sudarshana M., Stephens, Julie A., Fernandez, Soledad A., Gurcan, Metin N., Weinstein, Michael B., Barsky, Sanford H., Yee, Lisa, Rosol, Thomas J., Stromberg, Paul C., Robinson, Michael L., Pepin, Francois, Hallett, Michael, Park, Morag, Ostrowski, Michael C., and Leone, Gustavo

Subjects
Tumor suppressor genes -- Physiological aspects -- Health aspects -- Genetic aspects, Epithelial tumors -- Prevention -- Development and progression -- Genetic aspects, Fibroblasts -- Health aspects -- Physiological aspects -- Genetic aspects, Breast cancer -- Genetic aspects -- Development and progression -- Prevention, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

The tumour stroma is believed to contribute to some of the most malignant characteristics of epithelial tumours. However, signalling between stromal and tumour cells is complex and remains poorly understood. [...]

Published
2009
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9. Stromal Platelet–Derived Growth Factor Receptor-β Signaling Promotes Breast Cancer Metastasis in the Brain

Author

Thies, Katie A., primary, Hammer, Anisha M., additional, Hildreth, Blake E., additional, Steck, Sarah A., additional, Spehar, Jonathan M., additional, Kladney, Raleigh D., additional, Geisler, Jennifer A., additional, Das, Manjusri, additional, Russell, Luke O., additional, Bey, Jerome F., additional, Bolyard, Chelsea M., additional, Pilarski, Robert, additional, Trimboli, Anthony J., additional, Cuitiño, Maria C., additional, Koivisto, Christopher S., additional, Stover, Daniel G., additional, Schoenfield, Lynn, additional, Otero, Jose, additional, Godbout, Jonathan P., additional, Chakravarti, Arnab, additional, Ringel, Matthew D., additional, Ramaswamy, Bhuvaneswari, additional, Li, Zaibo, additional, Kaur, Balveen, additional, Leone, Gustavo, additional, Ostrowski, Michael C., additional, Sizemore, Steven T., additional, and Sizemore, Gina M., additional

Published
2021
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11. Stromal PTEN determines mammary epithelial response to radiotherapy

Author

Sizemore, Gina M., primary, Balakrishnan, Subhasree, additional, Thies, Katie A., additional, Hammer, Anisha M., additional, Sizemore, Steven T., additional, Trimboli, Anthony J., additional, Cuitiño, Maria C., additional, Steck, Sarah A., additional, Tozbikian, Gary, additional, Kladney, Raleigh D., additional, Shinde, Neelam, additional, Das, Manjusri, additional, Park, Dongju, additional, Majumder, Sarmila, additional, Krishnan, Shiva, additional, Yu, Lianbo, additional, Fernandez, Soledad A., additional, Chakravarti, Arnab, additional, Shields, Peter G., additional, White, Julia R., additional, Yee, Lisa D., additional, Rosol, Thomas J., additional, Ludwig, Thomas, additional, Park, Morag, additional, Leone, Gustavo, additional, and Ostrowski, Michael C., additional

Published
2018
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12. Abstract 49: Stromal platelet derived growth factor receptor (PDGFRβ) signaling: A novel therapeutic target for breast cancer brain metastasis (BCBM)

Author

Thies, Katie A., primary, Hammer, Anisha M., additional, Hildreth, B. Eason, additional, Russell, Luke O., additional, Sizemore, Steven T., additional, Trimboli, Anthony J., additional, Kladney, Raleigh D., additional, Bolyard, Chelsea M., additional, Pilarski, Robert, additional, Schoenfield, Lynn, additional, Otero, Jose, additional, Chakravarti, Arnab, additional, Ringel, Matthew, additional, Kaur, Balveen, additional, Leone, Gustavo, additional, Ostrowski, Michael C., additional, and Sizemore, Gina M., additional

Published
2018
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13. Abstract 3911: Stromal platelet derived growth factor receptor-beta (PDGFRbeta) promotes breast brain metastasis

Author

Thies, Katie A., primary, Hammer, Anisha M., additional, Trimboli, Anthony J., additional, Hildreth, B. Eason, additional, Russell, Luke O., additional, Bolyard, Chelsea M., additional, Kladney, Raleigh D., additional, Sizemore, Steven T., additional, Pilarski, Robert, additional, Schoenfield, Lynn, additional, Otero, Jose, additional, Chakravarti, Arnab, additional, Kaur, Balveen, additional, Leone, Gustavo, additional, Ostrowski, Michael C., additional, and Sizemore, Gina M., additional

Published
2017
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16. Ets2 in Tumor Fibroblasts Promotes Angiogenesis in Breast Cancer

Author

Wallace, Julie A., primary, Li, Fu, additional, Balakrishnan, Subhasree, additional, Cantemir-Stone, Carmen Z., additional, Pecot, Thierry, additional, Martin, Chelsea, additional, Kladney, Raleigh D., additional, Sharma, Sudarshana M., additional, Trimboli, Anthony J., additional, Fernandez, Soledad A., additional, Yu, Lianbo, additional, Rosol, Thomas J., additional, Stromberg, Paul C., additional, Lesurf, Robert, additional, Hallett, Michael, additional, Park, Morag, additional, Leone, Gustavo, additional, and Ostrowski, Michael C., additional

Published
2013
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18. Direct Evidence for Epithelial-Mesenchymal Transitions in Breast Cancer

Author

Trimboli, Anthony J., primary, Fukino, Koichi, additional, de Bruin, Alain, additional, Wei, Guo, additional, Shen, Lei, additional, Tanner, Stephan M., additional, Creasap, Nicholas, additional, Rosol, Thomas J., additional, Robinson, Michael L., additional, Eng, Charis, additional, Ostrowski, Michael C., additional, and Leone, Gustavo, additional

Published
2008
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24. Magnitude of peroxisome proliferator-activated receptor-gamma activation is associated with important and seemingly opposite biological responses in breast cancer cells.

Author

Clay, Carl E., Namen, Andrew M., Atsumi, Gen-ichi, Trimboli, Anthony J., Fonteh, Alfred N., High, Kevin P., Chilton, Floyd H., Clay, C E, Namen, A M, Atsumi, G, Trimboli, A J, Fonteh, A N, High, K P, and Chilton, F H

Subjects
CELL receptors, APOPTOSIS, BENZOPYRANS, BREAST tumors, CELL cycle, CELL differentiation, CELL division, GENES, PROSTAGLANDINS, THIAZOLES, TRANSCRIPTION factors, THIAZOLIDINEDIONES, CANCER cell culture, PHARMACODYNAMICS, CELL physiology
Abstract

Background: The nuclear receptor peroxisome proliferator-activated receptor-gamma (PPARgamma) has become a potential target for the prevention and treatment of breast cancer. However, recent in vitro and in vivo studies have raised the question of whether activation of PPARgamma leads to the promotion or reduction of tumor formation. Studies using several cancer cell lines, animal models, and a variety of PPARgamma agonists have shown discordant results, including changes in cellular proliferation, differentiation, and apoptosis of cancer cells and tumors.Methods: We studied the effects of low-, moderate-, and high-dose treatment of the PPARgamma ligands 15-deoxy-delta1214 prostaglandin J2 (15dPGJ2) and troglitazone (TGZ) on parameters of cell growth, differentiation, and apoptosis in the epithelial breast cancer cell line MDA-MB-231.Results: The biologic effects of these compounds depend largely on ligand concentration and the degree of PPARgamma activation. For example, low concentrations of 15dPGJ2 (<2.5 microM) and TGZ (<5 microM) increased cellular proliferation, but concentrations of 15dPGJ2 > or = 10 microM and of TGZ at 100 microM blocked cell growth. TGZ (100 microM) slowed cell cycle progression, and 15dPGJ2 (10 microM) caused an S-phase arrest in the cell cycle and induced morphological characteristics consistent with apoptosis. Expression of CD36, a marker of differentiation in these cells, was induced by 2.5 microM 15dPGJ2 or 5 to 100 microM TGZ. However, higher concentrations of 15dPGJ2 did not alter CD36 expression. Transcriptional activation studies demonstrated that 15dPGJ2 is a more potent PPARgamma ligand than TGZ. Regardless of the ligand used, though, low transcriptional activation correlated with an increased cellular proliferation, whereas higher levels of activation correlated with cell cycle arrest and apoptosis.Conclusions: PPARgamma activation induces several important and seemingly opposite changes in neoplastic cells, depending on the magnitude of PPARgamma activation. These data may explain, at least in part, some of the discordant results previously reported. [ABSTRACT FROM AUTHOR]

Published
2001
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