1. An asymptomatic new lesion on MRI is a relapse and should be treated accordingly – No.
- Author
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Chard, Declan T and Trip, S Anand
- Subjects
- *
CARDIOVASCULAR diseases risk factors , *MEDICAL research - Abstract
In the diagnosis and treatment of relapsing-remitting (RR) multiple sclerosis (MS), a relapse is a sentinel event. An MS relapse is diagnosed on clinical grounds; however, magnetic resonance imaging (MRI) studies have shown that about 5-10 new white matter (WM) lesions accrue per relapse diagnosed,[2] highlighting that symptomatic events substantially underestimate MS inflammatory activity. When considering MS disease-modifying treatments, MRI has played a very important role in drug development, and at a group level, a treatment effect on WM lesion accrual predicts the effect on relapses and does so in much smaller and shorter trials.[5] However, at the level of an individual with MS, we think that asymptomatic lesions seen on MRI should be regarded with greater caution. [Extracted from the article]
- Published
- 2019
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