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Your search keyword '"Tripp, Allie E."' showing total 7 results
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7 results on '"Tripp, Allie E."'

1. Mutation of serine-39 to threonine in thermostable secondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus changes enantiospecificity

Author

Tripp, Allie E., Burdette, Douglas S., Zeikus, J. Gregory, and Phillips, Robert S.

Subjects
Mutation (Biology) -- Research, Serine -- Research, Threonine -- Research, Chemistry
Abstract

Research was conducted to investigate the impact of the mutation of Ser39 to threonine on the enantiospecificity and regiospecificity of secondary alcohol dehydrogenases (SADH) from Thermoanaerobacter ethanolicus. This is the first experiment demonstrating a single mutation that results in significant effects on the enantiospecificity of an enzyme. Results indicate that (S)-2 butanol specificity decreased while (R)-2-pentanol specificity was enhanced due to mutation.

Published
1998

2. Novel bicyclo[3.1.0]hexane analogs as antagonists of metabotropic glutamate 2/3 receptors for the treatment of depression

Author

Dressman, Bruce A., Tromiczak, Eric G., Chappell, Mark D., Tripp, Allie E., Quimby, Steven J., Vetman, Tatiana, Fivush, Adam M., Matt, James, Jaramillo, Carlos, Li, Renhua, Khilevich, Albert, Blanco, Maria-Jesus, Smith, Stephon C., Carpintero, Mercedes, de Diego, José Eugenio, Barberis, Mario, García-Cerrada, Susana, Soriano, José F., Schkeryantz, Jeffrey M., Witkin, Jeffrey M., Wafford, Keith A., Seidel, Wesley, Britton, Thomas, Overshiner, Carl D., Li, Xia, Wang, Xu-Shan, Heinz, Beverly A., Catlow, John T., Swanson, Steven, Bedwell, David, Ornstein, Paul L., and Mitch, Charles H.

Published
2016
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3. Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity

Author

Chappell, Mark D., primary, Li, Renhua, additional, Smith, Stephon C., additional, Dressman, Bruce A., additional, Tromiczak, Eric G., additional, Tripp, Allie E., additional, Blanco, Maria-Jesus, additional, Vetman, Tatiana, additional, Quimby, Steven J., additional, Matt, James, additional, Britton, Thomas C., additional, Fivush, Adam M., additional, Schkeryantz, Jeffrey M., additional, Mayhugh, Daniel, additional, Erickson, Jon A., additional, Bures, Mark G., additional, Jaramillo, Carlos, additional, Carpintero, Mercedes, additional, Diego, José Eugenio de, additional, Barberis, Mario, additional, Garcia-Cerrada, Susana, additional, Soriano, José F., additional, Antonysamy, Stephen, additional, Atwell, Shane, additional, MacEwan, Iain, additional, Condon, Bradley, additional, Sougias, Christine, additional, Wang, Jing, additional, Zhang, Aiping, additional, Conners, Kris, additional, Groshong, Chris, additional, Wasserman, Stephen R., additional, Koss, John W., additional, Witkin, Jeffrey M., additional, Li, Xia, additional, Overshiner, Carl, additional, Wafford, Keith A., additional, Seidel, Wesley, additional, Wang, Xu-Shan, additional, Heinz, Beverly A., additional, Swanson, Steven, additional, Catlow, John T., additional, Bedwell, David W., additional, Monn, James A., additional, Mitch, Charles H., additional, and Ornstein, Paul L., additional

Published
2016
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4. Conversion of human-selective PPARα agonists to human/mouse dual agonists: a molecular modeling analysis

Author

Wang, Minmin, primary, Winneroski, Leonard L., additional, Ardecky, Robert J., additional, Babine, Robert E., additional, Brooks, Dawn A., additional, Etgen, Garret J., additional, Hutchison, Darrell R., additional, Kauffman, Raymond F., additional, Kunkel, Aaron, additional, Mais, Dale E., additional, Montrose-Rafizadeh, Chahrzad, additional, Ogilvie, Kathleen M., additional, Oldham, Brian A., additional, Peters, Mary K., additional, Rito, Christopher J., additional, Rungta, Deepa K., additional, Tripp, Allie E., additional, Wilson, Sarah B., additional, Xu, Yanping, additional, Zink, Richard W., additional, and McCarthy, James R., additional

Published
2004
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6. Design and Synthesis of α-Aryloxy-α-methylhydrocinnamic Acids: A Novel Class of Dual Peroxisome Proliferator-Activated Receptor α/γ Agonists

Author

Xu, Yanping, primary, Rito, Christopher J., additional, Etgen, Garret J., additional, Ardecky, Robert J., additional, Bean, James S., additional, Bensch, William R., additional, Bosley, Jacob R., additional, Broderick, Carol L., additional, Brooks, Dawn A., additional, Dominianni, Samuel J., additional, Hahn, Patric J., additional, Liu, Sha, additional, Mais, Dale E., additional, Montrose-Rafizadeh, Chahrzad, additional, Ogilvie, Kathy M., additional, Oldham, Brian A., additional, Peters, Mary, additional, Rungta, Deepa K., additional, Shuker, Anthony J., additional, Stephenson, Gregory A., additional, Tripp, Allie E., additional, Wilson, Sarah B., additional, Winneroski, Leonard L., additional, Zink, Richard, additional, Kauffman, Raymond F., additional, and McCarthy, James R., additional

Published
2004
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7. Design and synthesis of alpha-aryloxy-alpha-methylhydrocinnamic acids: a novel class of dual peroxisome proliferator-activated receptor alpha/gamma agonists.

Author

Xu Y, Rito CJ, Etgen GJ, Ardecky RJ, Bean JS, Bensch WR, Bosley JR, Broderick CL, Brooks DA, Dominianni SJ, Hahn PJ, Liu S, Mais DE, Montrose-Rafizadeh C, Ogilvie KM, Oldham BA, Peters M, Rungta DK, Shuker AJ, Stephenson GA, Tripp AE, Wilson SB, Winneroski LL, Zink R, Kauffman RF, and McCarthy JR

Subjects
Animals, Binding, Competitive, Cell Line, Diabetes Mellitus, Type 2 drug therapy, Female, Humans, Hyperlipidemias drug therapy, Hypoglycemic Agents chemistry, Hypoglycemic Agents pharmacology, Hypolipidemic Agents chemistry, Hypolipidemic Agents pharmacology, Phenylpropionates chemistry, Phenylpropionates pharmacology, Radioligand Assay, Rats, Rats, Zucker, Stereoisomerism, Structure-Activity Relationship, Thiophenes chemistry, Thiophenes pharmacology, Hypoglycemic Agents chemical synthesis, Hypolipidemic Agents chemical synthesis, Phenylpropionates chemical synthesis, Receptors, Cytoplasmic and Nuclear agonists, Thiophenes chemical synthesis, Transcription Factors agonists
Abstract

The design and synthesis of the dual peroxisome proliferator activated receptor (PPAR) alpha/gamma agonist (S)-2-methyl-3-[4-[2-(5-methyl-2-thiophen-2-yl-oxazol-4-yl)ethoxy]phenyl]-2-phenoxypropionic acid (2) for the treatment of type 2 diabetes and associated dyslipidemia are described. 2 possesses a potent dual hPPAR alpha/gamma agonist profile (IC(50) = 28 and 10 nM; EC(50) = 9 and 4 nM, respectively, for hPPARalpha and hPPARgamma). In preclinical models, 2 substantially improves insulin sensitivity and potently reverses diabetic hyperglycemia while significantly improving overall lipid homeostasis.

Published
2004
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