1. Isolation of C-29 oxygenated oleanane triterpenoids and a (+)-muurolene type sesquiterpenoid from the fruiting bodies of Fuscoporia torulosa and their bioactivities.
- Author
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Yoneyama T, Chen C, Ichimura Y, Nakashima K, Kenmoku H, Imagawa H, Umeyama A, and Noji M
- Subjects
- Molecular Structure, Basidiomycota chemistry, Oleanolic Acid chemistry, Oleanolic Acid analogs & derivatives, Oleanolic Acid isolation & purification, Oleanolic Acid pharmacology, Triterpenes chemistry, Triterpenes isolation & purification, Triterpenes pharmacology, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents chemistry, Anti-Bacterial Agents isolation & purification, Crystallography, X-Ray, Methicillin-Resistant Staphylococcus aureus drug effects, Fruiting Bodies, Fungal chemistry, Sesquiterpenes chemistry, Sesquiterpenes pharmacology, Sesquiterpenes isolation & purification, Microbial Sensitivity Tests
- Abstract
Basidiomycetes with a wide variety of skeletons of secondary metabolites can be expected to be the source of new interesting biological compounds. During our research on basidiomycetes, two new C-29 oxygenated oleanane-type triterpenes (1 and 2) and torulosacid (3), a muurolene type sesquiterpenoid with a five-membered ether ring along with nine known compounds (4-12), were isolated from the MeOH extract of the fruiting bodies of Fuscoporia torulosa. The structures of 1-3 were determined by NMR and HREIMS analysis. Further studies on the stereochemistry of 3 were conducted using X-ray crystallographic analysis and comparison of experimental and calculated ECD spectra. In the antimicrobial assay of isolates, 1, 7, and 9 showed growth inhibitory activity against methicillin-resistant Staphylococcus aureus and other gram-positive strains. Isolation of oleanane type triterpenes from fungi including basidiomycetes, is a unique report that could lead to further isolation of new compounds and the discovery of unique biosynthetic enzymes., (© 2024. The Author(s) under exclusive licence to The Japanese Society of Pharmacognosy.)
- Published
- 2024
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