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4. Spontaneous carotid dissection presenting lower cranial nerve palsies

Author

D. Guidetti, Claudio Morandi, Franco Giovanardi, Giulio Zuccoli, Anna Pisanello, and Troiso A

Subjects
Adult, medicine.medical_specialty, Palsy, Accessory nerve, business.industry, Carotid Artery, Internal, Dissection, Middle Aged, medicine.disease, Cranial Nerve Diseases, Surgery, Paresis, Carotid artery dissection, Hemiparesis, Neurology, medicine.artery, Spinal nerve, medicine, Paralysis, Humans, Female, Neurology (clinical), medicine.symptom, Internal carotid artery, business, Hypoglossal nerve
Abstract

Cranial nerve palsy in internal carotid artery (ICA) dissection occurs in 3--12% of all patients, but in 3% of these a syndrome of hemicranias and ipsilateral cranial nerve palsy is the sole manifestation of ICA dissection, and in 0.5% of cases there is only cranial nerve palsy without headache. We present two cases of lower cranial nerve palsy. The first patient, a 49-year-old woman, developed left eleventh and twelfth cranial nerve palsies and ipsilateral neck pain. The angio-RM showed an ICA dissection with stenosis of 50%, beginning about 2 cm before the carotid channel. The patient was treated with oral anticoagulant therapy and gradually improved, until complete clinical recovery. The second patient, a 38-year-old woman, presented right hemiparesis and neck pain. The left ICA dissection, beginning 2 cm distal to the bulb, was shown by ultrasound scanning of the carotid and confirmed by MR angiogram and angiography with lumen stenosis of 90%. Following hospitalisation, 20 days from the onset of symptoms, paresis of the left trapezius and sternocleidomastoideus muscles became evident. The patient was treated with oral anticoagulant therapy and only a slight right arm paresis was present at 10 months follow-up. Cranial nerve palsy is not rare in ICA dissection, and the lower cranial nerve palsies in various combinations constitute the main syndrome, but in most cases these are present with the motor or sensory deficit due to cerebral ischemia, along with headache or Horner's syndrome. In the diagnosis of the first case, there was further difficulty because the cranial nerve palsy was isolated without hemiparesis, and the second case presented a rare association of hemiparesis and palsy of the eleventh cranial nerve alone. Compression or stretching of the nerve by the expanded artery may explain the palsies, but an alternative cause is also possible, namely the interruption of the nutrient vessels supplying the nerve, which in our patients is more likely.

Published
2001
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5. Randomised controlled trial of streptokinase, aspirin, and combination of both in treatment of acute ischaemic stroke

Author

F Finzi, G Alunni, G Costantino, E Ghidoni, M Sfrappini, L Roveyaz, M Marra, J Wardlaw, A Ballini, G Lancia, F Zuccari, M Dicostanzo, A Brambilla, E Greco, L Melini, S Terenziani, E Moschini, G Marzara, A Gasparro, G Dalessandro, O Citterio, R Milani, A Pietra, S Comparetti, G Lama, D Sabatini, G Volpi, M Cruciani, L Ralli, A Vinattieri, L Casto, M Rottoli, S Ragaini, S Polonara, M Digiovanni, E Dejuli, G Danieli, P Menegazzo, A Brucato, O Marrazza, A Palumbo, F Costantini, I Laspina, E Righetti, F Deblasi, C Giorgi, G Landini, N Bonasera, L Calvi, A Lorizio, D Vanni, C Delfavero, L Provinciali, R Zucco, U Marini, R Nuzzi, F Cocco, G Crisi, C Defanti, M Porta, M Santangelo, E Pieragnoli, D Belladonna, L Giglia, D Sita, E Cani, V Lolli, S Spolveri, S Ricci, A Perreti, M Rascaroli, P Monaco, G Pisapia, G Candeliere, L Bagnoli, L Bruni, L Curatola, E Decapitani, R Capialbi, P Lattuada, J Bamford, M Poli, G Arena, R Diperri, F Pezzella, A Colombo, F Aloy, S Blanc, M Guidotti, G Baldassarri, A Garagnani, U Loi, C Leviminzi, V Romanazzi, C Sacchet, F Barzizza, V Avenia, M Taglioli, V Pontrelli, M Arnaboldi, G Trianni, F Raudino, A Bettinelli, G Russo, D Belvedere, P Infricciolo, A Paci, E Natali, G Santoro, M Correia, S Pasquali, G Pellegrini, D Mirabile, A Messina, G Alborini, J Bogousslavsky, F Colonna, A Randazzo, F Minotta, F Lincesso, G Degliantoni, T Carboni, A Martelli, A Pirisi, V Miele, P Girardi, C Menozzi, U Scoditti, F Cardopatri, M Santoni, S Gueli, C Scaccabarozzi, A Picchiarelli, M Camerlingo, L Carosella, A Mamoli, F Dacuno, D Tonti, A Troiso, P Piazza, A Castellano, M Veneziani, M Zampolini, S Santini, C Argentino, G Palmieri, G Pinardi, G Bovio, P Sandercock, A Boccali, M Baratti, R Musolino, G Tognoni, A Gatta, E Longhini, L Steidl, G Rosati, M Delgobbo, C Refi, P Panzetti, G Bissi, G Rizzato, M Pratesi, E Bottacchi, L Candelise, G Bollettini, L Fera, P Ottaviano, G Coppola, Vittorio Bertele, M Degiorgi, F Triolo, O Tafani, M Pallone, D Guidetti, N Marcello, C Scarpati, L Desantis, F Rizzitelli, C Conte, M Voloute, G Scialfa, G Lombardo, M Bianchi, G Micili, L Motti, D Bosone, C Fini, C Matacena, F Turiamo, R Luccioli, N Miele, F Rossi, D Gori, C Clarke, T Frattini, M Celani, G Thiella, A Cantini, F Schieroni, O Scarpino, M Masina, P Sorgato, G Capocchi, F Colombo, M Zocchi, I Mazzanti, A Trenta, R Cavestri, R Reginelli, P Bassi, G Grilli, A Fancellu, D Orrico, M Scarpa, M Franceschi, F Passeri, A Ghetti, M Bondi, M Spanu, C Motto, E Negri, M Rezzonico, T Lomuzio, E Pretolani, R Ciola, S Grasselli, G Erli, M Desimoni, D Bertuzzi, H Barnett, A Vemco, G Musco, C Degrandi, A Fennetry, B Censori, A Delfavero, B Biscottini, R Peto, F Federico, C Bonaventi, C Bascelli, G Malferrari, C Alli, D Porazzi, G Sgaroni, A Giannini, G Scarlato, E Boccardi, A Cavallini, R Sterzi, E Aritzu, P Dudine, M Stellio, F Clerici, F Porro, R Grandi, L Munari, M Pacini, S Bartolini, M Zadra, A Balotta, A Sensidoni, B Felice, F Locatelli, W Garuti, R Gobbato, F Solime, L Sallusto, C Warlow, G Pirazzoli, G Ferrarini, M Watt, P Perrone, N Caputo, R Menozzi, M Michelini, R Bellesi, A Lechi, F Marras, I Bartolini, E Pascarelli, I Dascola, G Casu, G Divizia, M Ceravolo, R Ibba, R Insabato, G Venables, I Iori, G Greco, M Deledda, N Bartolini, F Grandi, E Cerioli, S Biagini, G Grampa, P Bannister, F Sasanelli, S Canzi, T Riccardi, A Bartocci, F Basso, A Marceca, C Cappelletti, I Santilli, R Bettini, F Salsa, Maria Carla Roncaglioni, G Bottini, A Ciccone, G Rebucci, A Maggioni, P Marotta, G Iannone, C Longoni, F Milone, V Inchingolo, V Chioma, E Lanza, and R Ferani

Subjects
Aspirin, Randomized controlled trial, law, business.industry, Streptokinase, Anesthesia, Medicine, General Medicine, business, Acute ischemic stroke, law.invention, medicine.drug
Published
1995
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6. RANDOMIZED CONTROLLED TRIAL OF STREPTOKINASE, ASPIRIN, AND COMBINATION OF BOTH IN TREATMENT OF ACUTE ISCHEMIC STROKE

Author

CANDELISE L, ARITZU E, CICCONE A, RICCI S, WARDLAW J, TOGNONI G, RONCAGLIONI MC, NEGRI E, COLOMBO F, BOCCARDI E, DEGRANDI C, SCIALFA G, ARGENTINO C, BERTELE V, MAGGIONI AP, PERRONE P, BARNETT HJM, BOGOUSSLAVSKY J, DELFAVERO A, LOI U, PETO R, WARLOW C, CANZI S, COMPARETTI S, CLERICI F, PALUMBO A, SGARONI G, POLONARA S, REGINELLI R, CERAVOLO MG, PROVINCIALI L, DELGOBBO M, SCARPINO O, BOTTACCHI E, DALESSANDRO G, DIGIOVANNI M, BLANC S, ROVEYAZ L, RALLI L, VANNI D, REFI C, FEDERICO F, CONTE C, INCHINGOLO V, INSABATO R, SALSA F, LORIZIO A, ROTTOLI MR, BRUNI L, DEFANTI CA, FERA L, CAMERLINGO M, CASTO L, CENSORI B, MAMOLI A, PORAZZI D, GRAMPA G, LASPINA I, GIGLIA L, AVENIA V, GUELI S, LOLLI V, MIELE V, SANTANGELO M, COPPOLA G, TRIANNI G, MARRA M, GRECO E, TONTI D, PRETOLANI E, STELLIO M, ARNABOLDI M, CIOLA R, DANIELI G, REZZONICO M, GUIDOTTI M, PELLEGRINI G, RAUDINO F, DELFAVERO C, FRATTINI T, RICCARDI T, LEVIMINZI C, LOCATELLI F, PASSERI F, LOMBARDO G, COCCO F, PRATESI M, SANTINI S, CARDOPATRI F, TAFANI O, LANDINI GC, PIERAGNOLI E, BELLESI R, BAGNOLI L, GHETTI A, MARRAZZA OB, MENEGAZZO P, SPOLVERI S, CAPPELLETTI C, CANDELIERE G, COSTANTINO G, DACUNO F, LOMUZIO T, RIZZITELLI FP, BOVIO G, GRILLI GP, ZOCCHI M, MAZZANTI I, PISAPIA G, NUZZI R, RUSSO G, LAMA G, BALDASSARRI G, BETTINI R, CANI E, CERIOLI E, DEGIORGI M, GARAGNANI A, PASQUALI S, CHIOMA V, FINI C, MARZARA G, BALOTTA A, BERTUZZI D, MASINA M, MATACENA C, MICHELINI M, PIRAZZOLI G, SACCHET C, MAROTTA P, CALVI L, SCACCABAROZZI C, MENOZZI C, SASANELLI F, BASCELLI C, PONTRELLI V, SCHIERONI F, BELVEDERE D, DECAPITANI E, DICOSTANZO M, RASCAROLI M, CITTERIO O, MILANI R, CAPIALBI R, ARENA G, MUSOLINO R, DIPERRI R, BONAVENTI C, FINZI F, MESSINA A, ROMANAZZI V, STERZI R, BOTTINI G, SANTILLI I, BRUCATO A, DEJULI E, PALMIERI G, RAGAINI S, THIELLA G, ALLI C, CAROSELLA L, RIZZATO G, BIANCHI M, MOTTO C, PINARDI G, SCARLATO G, BETTINELLI A, PORRO F, RANDAZZO A, MARINI U, LATTUADA P, PIETRA A, FRANCESCHI M, VOLOUTE MA, MALFERRARI G, BONDI M, GARUTI W, MELINI L, COLOMBO A, ALBORINI G, PANZETTI P, SCARPA M, SORGATO P, CRISI G, BONASERA N, BASSO F, NATALI E, MONACO P, GASPARRO AM, TRIOLO F, LECHI A, COLONNA F, DASCOLA I, GIORGI C, SCODITTI U, BASSI P, MENOZZI R, PIAZZA P, DEGLIANTONI G, DESIMONI M, GIANNINI A, MICILI G, BOSONE D, CAVALLINI A, MARTELLI A, BARZIZZA F, POLI M, BIAGINI S, CAPOCCHI G, CELANI MG, PICCHIARELLI A, RIGHETTI E, ZAMPOLINI M, CAPUTO N, BARTOLINI S, SANTONI M, SITA D, TAGLIOLI M, VOLPI G, ROSSI F, ALOY F, CASTELLANO AE, MINOTTA F, GATTA A, VINATTIERI A, CANTINI A, REBUCCI GG, BISSI G, DEBLASI F, PASCARELLI E, TURIAMO F, GUIDETTI D, BARATTI M, FERRARINI G, GHIDONI E, GRECO G, MARCELLO N, MOTTI L, SOLIME F, TERENZIANI S, ZUCCO R, TROISO A, VENEZIANI M, IORI I, CURATOLA L, BOLLETTINI G, CARBONI T, GOBBATO R, INFRICCIOLO P, SABATINI D, SFRAPPINI M, FANCELLU A, CASU G, DELEDDA MG, SPANU MA, PIRISI A, MARRAS FA, ROSATI G, BRAMBILLA A, ERLI GC, FELICE B, GRANDI R, MIRABILE D, ZADRA M, CAVESTRI R, GORI D, LONGHINI E, MIELE N, DIVIZIA G, GRASSELLI S, PEZZELLA F, ZUCCARI F, SALLUSTO L, LINCESSO F, SCARPATI C, IANNONE G, BARTOCCI A, COSTANTINI F, DESANTIS L, LANCIA G, MOSCHINI E, PACI A, SENSIDONI A, TRENTA A, BARTOLINI N, OTTAVIANO P, BISCOTTINI B, ALUNNI G, BARTOLINI I, BELLADONNA D, BOCCALI A, CRUCIANI M, IBBA R, LUCCIOLI R, MARCECA A, PACINI M, PALLONE M, GIRARDI P, ORRICO D, LANZA E, BALLINI A, GRANDI FC, MUSCO G, STEIDL L, SANTORO G, VEMCO A, DUDINE P, MILONE FF, MUNARI L, PERRETI A, PORTA M, LONGONI C, FERANI R, WATT M, SANDERCOCK P, FENNETRY A, BANNISTER P, CLARKE CE, BAMFORD J, VENABLES G, CORREIA M, CANDELISE L, ARITZU E, CICCONE A, RICCI S, WARDLAW J, TOGNONI G, RONCAGLIONI MC, NEGRI E, COLOMBO F, BOCCARDI E, DEGRANDI C, SCIALFA G, ARGENTINO C, BERTELE V, MAGGIONI AP, PERRONE P, BARNETT HJM, BOGOUSSLAVSKY J, DELFAVERO A, LOI U, PETO R, WARLOW C, CANZI S, COMPARETTI S, CLERICI F, PALUMBO A, SGARONI G, POLONARA S, REGINELLI R, CERAVOLO MG, PROVINCIALI L, DELGOBBO M, SCARPINO O, BOTTACCHI E, DALESSANDRO G, DIGIOVANNI M, BLANC S, ROVEYAZ L, RALLI L, VANNI D, REFI C, FEDERICO F, CONTE C, INCHINGOLO V, INSABATO R, SALSA F, LORIZIO A, ROTTOLI MR, BRUNI L, DEFANTI CA, FERA L, CAMERLINGO M, CASTO L, CENSORI B, MAMOLI A, PORAZZI D, GRAMPA G, LASPINA I, GIGLIA L, AVENIA V, GUELI S, LOLLI V, MIELE V, SANTANGELO M, COPPOLA G, TRIANNI G, MARRA M, GRECO E, TONTI D, PRETOLANI E, STELLIO M, ARNABOLDI M, CIOLA R, DANIELI G, REZZONICO M, GUIDOTTI M, PELLEGRINI G, RAUDINO F, DELFAVERO C, FRATTINI T, RICCARDI T, LEVIMINZI C, LOCATELLI F, PASSERI F, LOMBARDO G, COCCO F, PRATESI M, SANTINI S, CARDOPATRI F, TAFANI O, LANDINI GC, PIERAGNOLI E, BELLESI R, BAGNOLI L, GHETTI A, MARRAZZA OB, MENEGAZZO P, SPOLVERI S, CAPPELLETTI C, CANDELIERE G, COSTANTINO G, DACUNO F, LOMUZIO T, RIZZITELLI FP, BOVIO G, GRILLI GP, ZOCCHI M, MAZZANTI I, PISAPIA G, NUZZI R, RUSSO G, LAMA G, BALDASSARRI G, BETTINI R, CANI E, CERIOLI E, DEGIORGI M, GARAGNANI A, PASQUALI S, CHIOMA V, FINI C, MARZARA G, BALOTTA A, BERTUZZI D, MASINA M, MATACENA C, MICHELINI M, PIRAZZOLI G, SACCHET C, MAROTTA P, CALVI L, SCACCABAROZZI C, MENOZZI C, SASANELLI F, BASCELLI C, PONTRELLI V, SCHIERONI F, BELVEDERE D, DECAPITANI E, DICOSTANZO M, RASCAROLI M, CITTERIO O, MILANI R, CAPIALBI R, ARENA G, MUSOLINO R, DIPERRI R, BONAVENTI C, FINZI F, MESSINA A, ROMANAZZI V, STERZI R, BOTTINI G, SANTILLI I, BRUCATO A, DEJULI E, PALMIERI G, RAGAINI S, THIELLA G, ALLI C, CAROSELLA L, RIZZATO G, BIANCHI M, MOTTO C, PINARDI G, SCARLATO G, BETTINELLI A, PORRO F, RANDAZZO A, MARINI U, LATTUADA P, PIETRA A, FRANCESCHI M, VOLOUTE MA, MALFERRARI G, BONDI M, GARUTI W, MELINI L, COLOMBO A, ALBORINI G, PANZETTI P, SCARPA M, SORGATO P, CRISI G, BONASERA N, BASSO F, NATALI E, MONACO P, GASPARRO AM, TRIOLO F, LECHI A, COLONNA F, DASCOLA I, GIORGI C, SCODITTI U, BASSI P, MENOZZI R, PIAZZA P, DEGLIANTONI G, DESIMONI M, GIANNINI A, MICILI G, BOSONE D, CAVALLINI A, MARTELLI A, BARZIZZA F, POLI M, BIAGINI S, CAPOCCHI G, CELANI MG, PICCHIARELLI A, RIGHETTI E, ZAMPOLINI M, CAPUTO N, BARTOLINI S, SANTONI M, SITA D, TAGLIOLI M, VOLPI G, ROSSI F, ALOY F, CASTELLANO AE, MINOTTA F, GATTA A, VINATTIERI A, CANTINI A, REBUCCI GG, BISSI G, DEBLASI F, PASCARELLI E, TURIAMO F, GUIDETTI D, BARATTI M, FERRARINI G, GHIDONI E, GRECO G, MARCELLO N, MOTTI L, SOLIME F, TERENZIANI S, ZUCCO R, TROISO A, VENEZIANI M, IORI I, CURATOLA L, BOLLETTINI G, CARBONI T, GOBBATO R, INFRICCIOLO P, SABATINI D, SFRAPPINI M, FANCELLU A, CASU G, DELEDDA MG, SPANU MA, PIRISI A, MARRAS FA, ROSATI G, BRAMBILLA A, ERLI GC, FELICE B, GRANDI R, MIRABILE D, ZADRA M, CAVESTRI R, GORI D, LONGHINI E, MIELE N, DIVIZIA G, GRASSELLI S, PEZZELLA F, ZUCCARI F, SALLUSTO L, LINCESSO F, SCARPATI C, IANNONE G, BARTOCCI A, COSTANTINI F, DESANTIS L, LANCIA G, MOSCHINI E, PACI A, SENSIDONI A, TRENTA A, BARTOLINI N, OTTAVIANO P, BISCOTTINI B, ALUNNI G, BARTOLINI I, BELLADONNA D, BOCCALI A, CRUCIANI M, IBBA R, LUCCIOLI R, MARCECA A, PACINI M, PALLONE M, GIRARDI P, ORRICO D, LANZA E, BALLINI A, GRANDI FC, MUSCO G, STEIDL L, SANTORO G, VEMCO A, DUDINE P, MILONE FF, MUNARI L, PERRETI A, PORTA M, LONGONI C, FERANI R, WATT M, SANDERCOCK P, FENNETRY A, BANNISTER P, CLARKE CE, BAMFORD J, VENABLES G, and CORREIA M

Abstract

In ischaemic stroke, thrombolytic drugs speed the recanalisation of intracerebral arteries. The effects of aspirin are not known. A trial was conducted to determine whether, separately or together, streptokinase and aspirin have clinical benefits in acute ischaemic stroke similar to those in acute myocardial infarction. 622 patients with acute ischaemic stroke within 6 hours of symptom onset were randomised with a 2x2 factorial design to (i) a 1-hour intravenous infusion of 1 . 5 MU streptokinase, (ii) 300 mg/day buffered aspirin for 10 days, (iii) both active treatments, or (iv) neither. Early results raised a question whether the trial should be continued. Streptokinase (alone or with aspirin) was associated with an excess of 10-day case fatality (odds ratio 2 . 7; 95% confidence interval 1 . 7-4 . 3; 2p

Published
1995

7. Enlarging tongue masses in neurofibromatosis type 1: MR findings of two cases

Author

G, Zuccoli, F, Ferrozzi, G, Tognini, and A, Troiso

Subjects
Adult, Male, Neurofibromatosis 1, Adolescent, Humans, Magnetic Resonance Imaging, Tongue Neoplasms
Abstract

Plexiform neurofibromas usually occur in the neck, pelvis, and extremities. Jaws and oral cavity plexiform neurofibromas have also been described. Magnetic resonance (MR) patterns for neurofibromas are typical. They include low-to-intermediate signal intensity on T1-weighted images, enhancement of the solid component of the tumor after contrast medium administration, heterogeneity on T2-weighted images, and in some cases, multiple target signs due to a collagen central area. We report MR findings of two neurofibromatosis type 1 (NF1) patients with enlarging tongue plexiform neurofibromas.

Published
2001

8. [Optic pathway gliomas in patients with neurofibromatosis type 1: clinical-neuroradiological integrated approach]

Author

Zuccoli G, Ferrozzi F, Signorini M, Virdis R, and Troiso A

Subjects
Adult, Male, Neurofibromatosis 1, Adolescent, Optic Nerve Neoplasms, Infant, Glioma, Magnetic Resonance Imaging, Neoplasms, Multiple Primary, Child, Preschool, Humans, Female, Child, Retrospective Studies
Abstract

To evaluate a patient population affected by Neurofibromatosis type 1 (NF1) with special reference to optic pathway gliomas.A total of 419 NF1 patients (222 men, 197 women) were retrospectively evaluated to show incidence, biological behaviour, neuroradiological and clinical presentation of optic pathway gliomas. Central Nervous System MR and ophthalmologic evaluations were reviewed.Thirty-two patients out of 419 (7.6%) showed the presence of optic pathway gliomas. Of these, 28 (87.2%) patients showed tumoral involvement of the optic chiasma. The right intracranial optic nerve was involved in 15 patients (46.8%), the left intracranial optic nerve in 18 (56.2%), the right extracranial optic nerve in 11 (34.3%), the left extracranial optic nerve in 10 (31.2%) and the right and left optic tracts in 6 (18.7%) patients. Geniculate body and optic radiation were not involved by tumour diffusion. Visual acuity testing was positive in 26/32 (81.2%), the fundus oculi in 11/32 (34.3%) patients and the visual field evaluation in 12/32 (37.5%) patients.In this study we showed an high correlation between optic pathway tumours and ophthalmologic abnormalities confirming the usefulness of an integrated clinical-neuroradiological approach in patients affected by NF1. We also described the biological behaviour of these tumours in our NF1 patient population.

Published
2001

9. [A magnetic resonance study of 39 children with different causes of short stature]

Author

Zuccoli, G., Ferrozzi, F., Troiso, A., Inverardi, T., Ubaldi, A., and Ghizzoni, Lucia

Subjects
Male, Hypothalamo-Hypophyseal System, Adolescent, Infant, Magnetic Resonance Imaging, Body Height, Pituitary Hormones, Child, Preschool, Humans, Female, Child, Dwarfism, Pituitary, Growth Disorders, Retrospective Studies
Abstract

To investigate the relationship between Magnetic Resonance (MR) findings and the presence of isolated growth hormone deficiency (IGHD) or multiple pituitary hormone deficiency (MPHD).39 children, 27 boys and 12 girls (mean age 9.6 years) were enrolled. The growth hormone deficiency and MPHD were defined by standard laboratory methods. MR scans of the hypothalamo-hypophyseal tract were carried out on all patients before the therapy. Perinatal histories were reviewed.The pituitary anterior lobe was considered small in 13/39 (33%). Twenty-six of 39 (66%) patients did not show any abnormalities of the hypothalamohypophyseal tract. An ectopic neurohypophysis was found in 8/39 patients (20%). Only 2 patients among those with an ectopic neurohypophysis showed a small anterior pituitary lobe. Thirty-three of 39 (84.6%) patients showed IGHD while 6/39 (15.4%) patients showed MPHD. Twenty-eight of 39 (71%) patients had a severe deficiency while 11/39 (28%) patients had a moderate deficiency.Our study confirms the usefulness of MRI in the diagnostic and therapeutic approach to short stature in children; in fact 48% of patients in our series showed MR findings reasonably related to hormonal deficiency.

Published
2000

10. [Spontaneous dissection of the internal carotid artery. A report of 2 cases]

Author

C, Morandi, D, Guidetti, F, Margini, G, Azzali, F, Giovanardi, and A, Troiso

Subjects
Adult, Male, Angiography, Digital Subtraction, Humans, Female, Carotid Artery, Internal, Dissection, Prognosis, Tomography, X-Ray Computed, Carotid Artery, Internal, Magnetic Resonance Angiography, Ultrasonography
Published
1999

11. [Percutaneous positioning of port catheter in the hepatic artery for chemotherapy of metastases using the Arai technique]

Author

C, Morandi, S, Colopi, Y, Arai, L, Molani, M, Cantone, E, Gallo, and A, Troiso

Subjects
Adult, Male, Antimetabolites, Antineoplastic, Antibiotics, Antineoplastic, Time Factors, Antidotes, Liver Neoplasms, Angiography, Leucovorin, Middle Aged, Radiography, Interventional, Mitomycins, Catheters, Indwelling, Hepatic Artery, Antineoplastic Combined Chemotherapy Protocols, Humans, Infusions, Intra-Arterial, Female, Radiography, Thoracic, Fluorouracil, Aged, Epirubicin
Abstract

Liver metastases from colorectal, gastric and breast cancers are a very frequent event; these metastases are treated with cycles of intraarterial chemotherapy with a permanent catheter positioned in the hepatic artery or with surgical or interventional radiology techniques. We tested Arai's technique and its feasibility and evaluated the efficacy of this chemotherapy schedule.Four patients with liver metastases from colorectal carcinoma were treated with combined systemic and locoregional chemotherapy with a permanent catheter placed in the hepatic artery according to Arai's technique. Arai's technique consists in studying the hepatic vascularization and then redistributing hepatic flow in case of multiple hepatic arteries; the vessels in which the infusion of chemotherapies could cause toxicity are then occluded and finally a catheter is positioned in the hepatic artery with subclavian artery catheterization and the connection with a subcutaneous reservoir for injection--the port-a-cath system. We planned CT examinations to study liver morphology and radiographs of the abdomen and chest to depict the catheter position and patency, respectively.The catheter was positioned correctly without any complications in all patients, as planned. We administered 37 cycles of combined systemic and locoregional chemotherapy in all. Two patients died of disease progression after 6 months but the other 2 are still alive and CT showed partial disease remission. We observed no catheter dislocation or occlusion at chest radiography and transport angiography, respectively.Infusion chemotherapy in the hepatic artery from permanent catheters is widely accepted in our country and we believe that Arai's technique could be an alternative to the more classic and established surgery. The small number of our patients and the short follow-up do not permit definitive conclusions to be drawn on the clinical efficacy of this combined systemic and intra-arterial treatment.

Published
1998

12. [Quality assurance in radiology: quality control of radiographic cassettes]

Author

P P, Ferretti, M, Sarti, P, Messori, L, Boni, P, Seligardi, D, Tassoni, V, Cattini, V, Piccagli, A, Barani, C, Bianchi, G, Borasi, A, Troiso, and C, Soliani Raschini

Subjects
Quality Control, Radiography, Quality Assurance, Health Care, Evaluation Studies as Topic, Humans, Radiology
Abstract

A "quality team" in radiology, whose members are the authors of this paper, has implemented a quality control program to test the cassettes with intensifying screen systems used in radiology departments. 149 systems-124 of them for general purpose radiology and 25 for mammography-were submitted to the following tests: visual inspection of radiographic cassettes and intensifying screens, screen-film contact, intensifying screen cleanliness and relative sensitivity of the intensifying screens. The results of each type of test are reported in detail in the paper, on a 3-point scale: good, sufficient and poor. The overall results of the quality control tests show 78% of general purpose radiology cassettes to qualify as good (69%) or sufficient (9%), while 22% were of poor quality. 88% of the mammographic cassettes qualified as good (76%) or sufficient (12%), while 12% were of poor quality. All tests were easy to perform and required limited resources. The necessary procedures to keep quality high over time are also reported. To conclude, the results obtained with our quality control program could be used as an effective tool to address and plan the turnover of the cassettes with intensifying screens which are usually used in diagnostic radiology practice.

Published
1996

13. RANDOMIZED CONTROLLED TRIAL OF STREPTOKINASE, ASPIRIN, AND COMBINATION OF BOTH IN TREATMENT OF ACUTE ISCHEMIC STROKE

Author

CANDELISE, L, ARITZU, E, CICCONE, A, RICCI, S, WARDLAW, J, TOGNONI, G, RONCAGLIONI, M, NEGRI, E, COLOMBO, F, BOCCARDI, E, DEGRANDI, C, SCIALFA, G, ARGENTINO, C, BERTELE, V, MAGGIONI, A, PERRONE, P, BARNETT, H, BOGOUSSLAVSKY, J, DELFAVERO, A, LOI, U, PETO, R, WARLOW, C, CANZI, S, COMPARETTI, S, CLERICI, F, PALUMBO, A, SGARONI, G, POLONARA, S, REGINELLI, R, CERAVOLO, M, PROVINCIALI, L, DELGOBBO, M, SCARPINO, O, BOTTACCHI, E, DALESSANDRO, G, DIGIOVANNI, M, BLANC, S, ROVEYAZ, L, RALLI, L, VANNI, D, REFI, C, FEDERICO, F, CONTE, C, INCHINGOLO, V, INSABATO, R, SALSA, F, LORIZIO, A, ROTTOLI, M, BRUNI, L, DEFANTI, C, FERA, L, CAMERLINGO, M, CASTO, L, CENSORI, B, MAMOLI, A, PORAZZI, D, GRAMPA, G, LASPINA, I, GIGLIA, L, AVENIA, V, GUELI, S, LOLLI, V, MIELE, V, SANTANGELO, M, COPPOLA, G, TRIANNI, G, MARRA, M, GRECO, E, TONTI, D, PRETOLANI, E, STELLIO, M, ARNABOLDI, M, CIOLA, R, DANIELI, G, REZZONICO, M, GUIDOTTI, M, PELLEGRINI, G, RAUDINO, F, DELFAVERO, C, FRATTINI, T, RICCARDI, T, LEVIMINZI, C, LOCATELLI, F, PASSERI, F, LOMBARDO, G, COCCO, F, PRATESI, M, SANTINI, S, CARDOPATRI, F, TAFANI, O, LANDINI, G, PIERAGNOLI, E, BELLESI, R, BAGNOLI, L, GHETTI, A, MARRAZZA, O, MENEGAZZO, P, SPOLVERI, S, CAPPELLETTI, C, CANDELIERE, G, COSTANTINO, G, DACUNO, F, LOMUZIO, T, RIZZITELLI, F, BOVIO, G, GRILLI, G, ZOCCHI, M, MAZZANTI, I, PISAPIA, G, NUZZI, R, RUSSO, G, LAMA, G, BALDASSARRI, G, BETTINI, R, CANI, E, CERIOLI, E, DEGIORGI, M, GARAGNANI, A, PASQUALI, S, CHIOMA, V, FINI, C, MARZARA, G, BALOTTA, A, BERTUZZI, D, MASINA, M, MATACENA, C, MICHELINI, M, PIRAZZOLI, G, SACCHET, C, MAROTTA, P, CALVI, L, SCACCABAROZZI, C, MENOZZI, C, SASANELLI, F, BASCELLI, C, PONTRELLI, V, SCHIERONI, F, BELVEDERE, D, DECAPITANI, E, DICOSTANZO, M, RASCAROLI, M, CITTERIO, O, MILANI, R, CAPIALBI, R, ARENA, G, MUSOLINO, R, DIPERRI, R, BONAVENTI, C, FINZI, F, MESSINA, A, ROMANAZZI, V, STERZI, R, BOTTINI, G, SANTILLI, I, BRUCATO, A, DEJULI, E, PALMIERI, G, RAGAINI, S, THIELLA, G, ALLI, C, CAROSELLA, L, RIZZATO, G, BIANCHI, M, MOTTO, C, PINARDI, G, SCARLATO, G, BETTINELLI, A, PORRO, F, RANDAZZO, A, MARINI, U, LATTUADA, P, PIETRA, A, FRANCESCHI, M, VOLOUTE, M, MALFERRARI, G, BONDI, M, GARUTI, W, MELINI, L, COLOMBO, A, ALBORINI, G, PANZETTI, P, SCARPA, M, SORGATO, P, CRISI, G, BONASERA, N, BASSO, F, NATALI, E, MONACO, P, GASPARRO, A, TRIOLO, F, LECHI, A, COLONNA, F, DASCOLA, I, GIORGI, C, SCODITTI, U, BASSI, P, MENOZZI, R, PIAZZA, P, DEGLIANTONI, G, DESIMONI, M, GIANNINI, A, MICILI, G, BOSONE, D, CAVALLINI, A, MARTELLI, A, BARZIZZA, F, POLI, M, BIAGINI, S, CAPOCCHI, G, CELANI, M, PICCHIARELLI, A, RIGHETTI, E, ZAMPOLINI, M, CAPUTO, N, BARTOLINI, S, SANTONI, M, SITA, D, TAGLIOLI, M, VOLPI, G, ROSSI, F, ALOY, F, CASTELLANO, A, MINOTTA, F, GATTA, A, VINATTIERI, A, CANTINI, A, REBUCCI, G, BISSI, G, DEBLASI, F, PASCARELLI, E, TURIAMO, F, GUIDETTI, D, BARATTI, M, FERRARINI, G, GHIDONI, E, GRECO, G, MARCELLO, N, MOTTI, L, SOLIME, F, TERENZIANI, S, ZUCCO, R, TROISO, A, VENEZIANI, M, IORI, I, CURATOLA, L, BOLLETTINI, G, CARBONI, T, GOBBATO, R, INFRICCIOLO, P, SABATINI, D, SFRAPPINI, M, FANCELLU, A, CASU, G, DELEDDA, M, SPANU, M, PIRISI, A, MARRAS, F, ROSATI, G, BRAMBILLA, A, ERLI, G, FELICE, B, GRANDI, R, MIRABILE, D, ZADRA, M, CAVESTRI, R, GORI, D, LONGHINI, E, MIELE, N, DIVIZIA, G, GRASSELLI, S, PEZZELLA, F, ZUCCARI, F, SALLUSTO, L, LINCESSO, F, SCARPATI, C, IANNONE, G, BARTOCCI, A, COSTANTINI, F, DESANTIS, L, LANCIA, G, MOSCHINI, E, PACI, A, SENSIDONI, A, TRENTA, A, BARTOLINI, N, OTTAVIANO, P, BISCOTTINI, B, ALUNNI, G, BARTOLINI, I, BELLADONNA, D, BOCCALI, A, CRUCIANI, M, IBBA, R, LUCCIOLI, R, MARCECA, A, PACINI, M, PALLONE, M, GIRARDI, P, ORRICO, D, LANZA, E, BALLINI, A, GRANDI, F, MUSCO, G, STEIDL, L, SANTORO, G, VEMCO, A, DUDINE, P, MILONE, F, MUNARI, L, PERRETI, A, PORTA, M, LONGONI, C, FERANI, R, WATT, M, SANDERCOCK, P, FENNETRY, A, BANNISTER, P, CLARKE, C, BAMFORD, J, VENABLES, G, and CORREIA, M

Published
1995

14. [The use of high-field magnetic resonance in the follow-up of patients with mechanic aortic valve prosthesis and composite aortic tubular prosthesis]

Author

G, Alberti, A, Capuani, A, Raisaro, A, Troiso, and S, Lanza

Subjects
Adult, Male, Electromagnetic Fields, Postoperative Complications, Aortic Valve, Heart Valve Prosthesis, Humans, Female, Middle Aged, Magnetic Resonance Imaging, Aorta, Aged, Blood Vessel Prosthesis
Abstract

Eleven patients who had undergone cardiac surgery were studied by means of high-field MR imaging (1.5 T). Six patients had had aortic root and valve replaced with a Björk-Shiley (BS) composite tubular aortic graft prosthesis for acute dissection of ascending aorta. In the other 5 patients with rheumatic calcific aortic disease, the valve had been replaced with a BS prosthesis. As a whole, MRI studies were 14. Previous evaluations of magnetic field effects had seem carried out ex vivo on both BS valves and BS composite prostheses, on surgical ligation clips (Tantalium and Stainless) and on stainless wires for sternal closure. In 4 patients (2 BS composite grafts and 2 BS valves) MRI diagnosed chronic dissection of both arch and descending aorta. In 1 of them, with a BS valve, associated localized acute dissection of ascending aorta was observed. In 3 patients with BS composite grafts, MRI revealed pseudo-aneurysms (including a thrombosed one) at the graft level. In one case MRI was repeated 4 times and was very helpful in monitoring the pseudo-aneurysm. MRI showed pericardial hematoma in 2 patients with BS grafts and paravalvular abscess in a case with BS valve. In one patient with BS valve fast-imaging MR revealed severe aortic regurgitation. No adverse reactions were demonstrated on MR images of prosthetic implants. MRI artifacts were insignificant with the spin-echo technique, while the fast-imaging technique showed clear image distortion at the valve level.

Published
1990

17. Congenital hemiplegia: Correlation among CT morphology, epilepsy, and motor disability

Author

Gianna Bertani, Franco Nicoli, Antonella Pini, Adriano Ferrari, Giuseppe Gobbi, and Antonio Troiso

Subjects
medicine.medical_specialty, business.industry, medicine.disease, Epilepsy, Physical medicine and rehabilitation, Developmental Neuroscience, Neurology, Pediatrics, Perinatology and Child Health, medicine, Physical therapy, Neurology (clinical), business, Congenital hemiplegia, Motor disability
Published
1994
Full Text
View/download PDF

21. [Femoral neuropathy in anticoagulant therapy]

Author

M, Meinero, C, Pedrazzoli, G C, Piccinini, G, Bedogni, N, Marcello, and A, Troiso

Subjects
Adult, Hematoma, Heparin, Nerve Compression Syndromes, Humans, Female, Retroperitoneal Space, Femoral Nerve
Published
1985

26. [Spontaneous dissection of the internal carotid artery. A report of 2 cases].

Author

Morandi C, Guidetti D, Margini F, Azzali G, Giovanardi F, and Troiso A

Subjects
Adult, Angiography, Digital Subtraction, Carotid Artery, Internal diagnostic imaging, Carotid Artery, Internal pathology, Female, Humans, Magnetic Resonance Angiography, Male, Prognosis, Tomography, X-Ray Computed, Ultrasonography, Carotid Artery, Internal, Dissection diagnosis
Published
1999

27. [Percutaneous positioning of port catheter in the hepatic artery for chemotherapy of metastases using the Arai technique].

Author

Morandi C, Colopi S, Arai Y, Molani L, Cantone M, Gallo E, and Troiso A

Subjects
Adult, Aged, Angiography, Antibiotics, Antineoplastic administration & dosage, Antidotes administration & dosage, Antimetabolites, Antineoplastic administration & dosage, Epirubicin administration & dosage, Female, Fluorouracil administration & dosage, Humans, Leucovorin administration & dosage, Liver Neoplasms secondary, Male, Middle Aged, Mitomycins administration & dosage, Radiography, Interventional, Radiography, Thoracic, Time Factors, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Catheters, Indwelling, Hepatic Artery diagnostic imaging, Infusions, Intra-Arterial instrumentation, Liver Neoplasms drug therapy
Abstract

Introduction: Liver metastases from colorectal, gastric and breast cancers are a very frequent event; these metastases are treated with cycles of intraarterial chemotherapy with a permanent catheter positioned in the hepatic artery or with surgical or interventional radiology techniques. We tested Arai's technique and its feasibility and evaluated the efficacy of this chemotherapy schedule., Material and Methods: Four patients with liver metastases from colorectal carcinoma were treated with combined systemic and locoregional chemotherapy with a permanent catheter placed in the hepatic artery according to Arai's technique. Arai's technique consists in studying the hepatic vascularization and then redistributing hepatic flow in case of multiple hepatic arteries; the vessels in which the infusion of chemotherapies could cause toxicity are then occluded and finally a catheter is positioned in the hepatic artery with subclavian artery catheterization and the connection with a subcutaneous reservoir for injection--the port-a-cath system. We planned CT examinations to study liver morphology and radiographs of the abdomen and chest to depict the catheter position and patency, respectively., Results: The catheter was positioned correctly without any complications in all patients, as planned. We administered 37 cycles of combined systemic and locoregional chemotherapy in all. Two patients died of disease progression after 6 months but the other 2 are still alive and CT showed partial disease remission. We observed no catheter dislocation or occlusion at chest radiography and transport angiography, respectively., Conclusions: Infusion chemotherapy in the hepatic artery from permanent catheters is widely accepted in our country and we believe that Arai's technique could be an alternative to the more classic and established surgery. The small number of our patients and the short follow-up do not permit definitive conclusions to be drawn on the clinical efficacy of this combined systemic and intra-arterial treatment.

Published
1998

28. [Quality assurance in radiology: quality control of radiographic cassettes].

Author

Ferretti PP, Sarti M, Messori P, Boni L, Seligardi P, Tassoni D, Cattini V, Piccagli V, Barani A, Bianchi C, Borasi G, Troiso A, and Soliani Raschini C

Subjects
Evaluation Studies as Topic, Humans, Quality Assurance, Health Care, Quality Control, Radiography instrumentation, Radiography standards, Radiology instrumentation, Radiology standards
Abstract

A "quality team" in radiology, whose members are the authors of this paper, has implemented a quality control program to test the cassettes with intensifying screen systems used in radiology departments. 149 systems-124 of them for general purpose radiology and 25 for mammography-were submitted to the following tests: visual inspection of radiographic cassettes and intensifying screens, screen-film contact, intensifying screen cleanliness and relative sensitivity of the intensifying screens. The results of each type of test are reported in detail in the paper, on a 3-point scale: good, sufficient and poor. The overall results of the quality control tests show 78% of general purpose radiology cassettes to qualify as good (69%) or sufficient (9%), while 22% were of poor quality. 88% of the mammographic cassettes qualified as good (76%) or sufficient (12%), while 12% were of poor quality. All tests were easy to perform and required limited resources. The necessary procedures to keep quality high over time are also reported. To conclude, the results obtained with our quality control program could be used as an effective tool to address and plan the turnover of the cassettes with intensifying screens which are usually used in diagnostic radiology practice.

Published
1996

29. [The use of high-field magnetic resonance in the follow-up of patients with mechanic aortic valve prosthesis and composite aortic tubular prosthesis].

Author

Alberti G, Capuani A, Raisaro A, Troiso A, and Lanza S

Subjects
Adult, Aged, Aorta, Aortic Valve, Electromagnetic Fields, Female, Humans, Male, Middle Aged, Blood Vessel Prosthesis, Heart Valve Prosthesis, Magnetic Resonance Imaging, Postoperative Complications diagnosis
Abstract

Eleven patients who had undergone cardiac surgery were studied by means of high-field MR imaging (1.5 T). Six patients had had aortic root and valve replaced with a Björk-Shiley (BS) composite tubular aortic graft prosthesis for acute dissection of ascending aorta. In the other 5 patients with rheumatic calcific aortic disease, the valve had been replaced with a BS prosthesis. As a whole, MRI studies were 14. Previous evaluations of magnetic field effects had seem carried out ex vivo on both BS valves and BS composite prostheses, on surgical ligation clips (Tantalium and Stainless) and on stainless wires for sternal closure. In 4 patients (2 BS composite grafts and 2 BS valves) MRI diagnosed chronic dissection of both arch and descending aorta. In 1 of them, with a BS valve, associated localized acute dissection of ascending aorta was observed. In 3 patients with BS composite grafts, MRI revealed pseudo-aneurysms (including a thrombosed one) at the graft level. In one case MRI was repeated 4 times and was very helpful in monitoring the pseudo-aneurysm. MRI showed pericardial hematoma in 2 patients with BS grafts and paravalvular abscess in a case with BS valve. In one patient with BS valve fast-imaging MR revealed severe aortic regurgitation. No adverse reactions were demonstrated on MR images of prosthetic implants. MRI artifacts were insignificant with the spin-echo technique, while the fast-imaging technique showed clear image distortion at the valve level.

Published
1990

31. Secreting breast: the role of galactography.

Author

Alberti GP and Troiso A

Subjects
Adult, Aged, Breast Neoplasms diagnostic imaging, Carcinoma diagnostic imaging, Female, Fibrocystic Breast Disease diagnostic imaging, Humans, Mastitis diagnostic imaging, Middle Aged, Papilloma diagnostic imaging, Pregnancy, Breast metabolism, Breast Diseases diagnostic imaging, Mammography
Abstract

Galactography is the most important instrumental examination in the diagnostics of secreting breast. The authors describe the direct radiologic pictures of the galactoforous ducts as well as the changes of the ductal walls and lumen as shown by the radiologic examination by contrast media. The study finally reports statistical data concerning a personal case-series of 324 patients presenting surgically managed breast secretion and divided according to age. This analysis shows that the highest incidence of galactophoritis, secreting ductal ectasia and fibrocystic mastopathy occurs between 31 and 50 years of age, whereas papilloma, intraductal papillomatosis and carcinoma are more frequently observed between 41 and 60 years.

Published
1982

32. [Femoral neuropathy in anticoagulant therapy].

Author

Meinero M, Pedrazzoli C, Piccinini GC, Bedogni G, Marcello N, and Troiso A

Subjects
Adult, Female, Hematoma chemically induced, Humans, Retroperitoneal Space, Femoral Nerve, Hematoma complications, Heparin adverse effects, Nerve Compression Syndromes etiology
Published
1985

35. [Vascular compression of the duodenum associated with compression of the celiac axis].

Author

Pezza V, Prati R, Troiso A, and Ferrari G

Subjects
Adult, Constriction, Pathologic diagnostic imaging, Duodenal Obstruction diagnostic imaging, Female, Humans, Radiography, Superior Mesenteric Artery Syndrome diagnostic imaging, Superior Mesenteric Artery Syndrome surgery, Celiac Artery diagnostic imaging, Duodenal Obstruction diagnosis, Duodenal Obstruction etiology, Superior Mesenteric Artery Syndrome diagnosis
Published
1987

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