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Your search keyword '"Troyer, Deryl L."' showing total 147 results
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147 results on '"Troyer, Deryl L."'

1. Optical biosensing of markers of mucosal inflammation

Author

Covarrubias-Zambrano, Obdulia, Motamedi, Massoud, Ameredes, Bill T., Tian, Bing, Calhoun, William J., Zhao, Yingxin, Brasier, Allan R., Kalubowilage, Madumali, Malalasekera, Aruni P., Yapa, Asanka S., Wang, Hongwang, Culbertson, Christopher T., Troyer, Deryl L., and Bossmann, Stefan H.

Published
2022
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3. Rationally designed peptide nanosponges for cell-based cancer therapy

Author

Wang, Hongwang, Yapa, Asanka S., Kariyawasam, Nilusha L., Shrestha, Tej B., Kalubowilage, Madumali, Wendel, Sebastian O., Yu, Jing, Pyle, Marla, Basel, Matthew T., Malalasekera, Aruni P., Toledo, Yubisela, Ortega, Raquel, Thapa, Prem S., Huang, Hongzhou, Sun, Susan X., Smith, Paul E., Troyer, Deryl L., and Bossmann, Stefan H.

Published
2017
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10. Stem cell-based photodynamic therapy

Author

Shrestha, Tej B., Seo, Gwi M., Basel, Matthew T., Kalita, Mausam, Wang, Hongwang, Villanueva, David, Pyle, Marla, Balivada, Sivasai, Rachakatla, Raja Shekar, Shinogle, Heather, Thapa, Prem S., Moore, David, Troyer, Deryl L., and Bossmann, Stefan H.

Published
2012
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17. A/C magnetic hyperthermia of melanoma mediated by iron(0)/iron oxide core/shell magnetic nanoparticles: a mouse study

Author

Koper Olga B, Leaym Xiaoxuan, Walker Brandon, Kroh Franklin O, Pyle Marla, Dani Raj, Samarakoon Thilani N, Wang Hongwang, Rachakatla Raja, Balivada Sivasai, Tamura Masaaki, Chikan Viktor, Bossmann Stefan H, and Troyer Deryl L

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background There is renewed interest in magnetic hyperthermia as a treatment modality for cancer, especially when it is combined with other more traditional therapeutic approaches, such as the co-delivery of anticancer drugs or photodynamic therapy. Methods The influence of bimagnetic nanoparticles (MNPs) combined with short external alternating magnetic field (AMF) exposure on the growth of subcutaneous mouse melanomas (B16-F10) was evaluated. Bimagnetic Fe/Fe3O4 core/shell nanoparticles were designed for cancer targeting after intratumoral or intravenous administration. Their inorganic center was protected against rapid biocorrosion by organic dopamine-oligoethylene glycol ligands. TCPP (4-tetracarboxyphenyl porphyrin) units were attached to the dopamine-oligoethylene glycol ligands. Results The magnetic hyperthermia results obtained after intratumoral injection indicated that micromolar concentrations of iron given within the modified core-shell Fe/Fe3O4 nanoparticles caused a significant anti-tumor effect on murine B16-F10 melanoma with three short 10-minute AMF exposures. We also observed a decrease in tumor size after intravenous administration of the MNPs followed by three consecutive days of AMF exposure 24 hrs after the MNPs injection. Conclusions These results indicate that intratumoral administration of surface modified MNPs can attenuate mouse melanoma after AMF exposure. Moreover, we have found that after intravenous administration of micromolar concentrations, these MNPs are capable of causing an anti-tumor effect in a mouse melanoma model after only a short AMF exposure time. This is a clear improvement to state of the art.

Published
2010
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18. Peptide nanosponges designed for rapid uptake by leukocytes and neural stem cells

Author

Yapa, Asanka S., Wang, Hongwang, Wendel, Sebastian O., Shrestha, Tej. B., Kariyawasam, Nilusha L., Kalubowilage, Madumali, Perera, Ayomi S., Pyle, Marla, Basel, Matthew T., Malalasekera, Aruni P., Manawadu, Harshi, Yu, Jing, Toledo, Yubisela, Ortega, Raquel, Thapa, Prem S., Smith, Paul E., Troyer, Deryl L., and Bossmann, Stefan H.

Subjects
chemistry
Abstract

The structure of novel binary nanosponges consisting of (cholesterol-(K/D)ₙDEVDGC)₃-trimaleimide units possessing a trigonal maleimide linker, to which either lysine (K)₂₀ or aspartic acid (D)₂₀ are tethered, has been elucidated by means of TEM. A high degree of agreement between these findings and structure predictions through explicit solvent and then coarse-grained molecular dynamics (MD) simulations has been found. Based on the nanosponges' structure and dynamics, caspase-6 mediated release of the model drug 5(6)-carboxyfluorescein has been demonstrated. Furthermore, the binary (DK20) nanosponges have been found to be virtually non-toxic in cultures of neural progenitor cells. It is of a special importance for the future development of cell-based therapies that DK20 nanosponges were taken up efficiently by leucocytes (WBC) in peripheral blood within 3 h of exposure. The percentage of live cells among the WBC was not significantly decreased by the DK20 nanosponges. In contrast to stem cell or leucocyte cell cultures, which have to be matched to the patient, autologous cells are optimal for cell-mediated therapy. Therefore, the nanosponges hold great promise for effective cell-based tumor targeting.

Published
2018

19. Peptide Nanosponges Designed for the Delivery of Perillyl Alcohol to Glioma Cells

Author

Yapa, Asanka S., primary, Shrestha, Tej B., additional, Wendel, Sebastian O., additional, Kalubowilage, Madumali, additional, Yu, Jing, additional, Wang, Hongwang, additional, Pyle, Marla, additional, Basel, Matthew T., additional, Toledo, Yubisela, additional, Ortega, Raquel, additional, Malalasekera, Aruni P., additional, Thapa, Prem S., additional, Troyer, Deryl L., additional, and Bossmann, Stefan H., additional

Published
2018
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20. Early detection of pancreatic cancers in liquid biopsies by ultrasensitive fluorescence nanobiosensors

Author

Kalubowilage, Madumali, primary, Covarrubias-Zambrano, Obdulia, additional, Malalasekera, Aruni P., additional, Wendel, Sebastian O., additional, Wang, Hongwang, additional, Yapa, Asanka S., additional, Chlebanowski, Lauren, additional, Toledo, Yubisela, additional, Ortega, Raquel, additional, Janik, Katharine E., additional, Shrestha, Tej B., additional, Culbertson, Christopher T., additional, Kasi, Anup, additional, Williamson, Stephen, additional, Troyer, Deryl L., additional, and Bossmann, Stefan H., additional

Published
2018
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21. Peptide nanosponges designed for rapid uptake by leukocytes and neural stem cells

Author

Yapa, Asanka S., primary, Wang, Hongwang, additional, Wendel, Sebastian O., additional, Shrestha, Tej. B., additional, Kariyawasam, Nilusha L., additional, Kalubowilage, Madumali, additional, Perera, Ayomi S., additional, Pyle, Marla, additional, Basel, Matthew T., additional, Malalasekera, Aruni P., additional, Manawadu, Harshi, additional, Yu, Jing, additional, Toledo, Yubisela, additional, Ortega, Raquel, additional, Thapa, Prem S., additional, Smith, Paul E., additional, Troyer, Deryl L., additional, and Bossmann, Stefan H., additional

Published
2018
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25. Early breast cancer screening using iron/iron oxide-based nanoplatforms with sub-femtomolar limits of detection

Author

Udukala, Dinusha N, primary, Wang, Hongwang, additional, Wendel, Sebastian O, additional, Malalasekera, Aruni P, additional, Samarakoon, Thilani N, additional, Yapa, Asanka S, additional, Abayaweera, Gayani, additional, Basel, Matthew T, additional, Maynez, Pamela, additional, Ortega, Raquel, additional, Toledo, Yubisela, additional, Bossmann, Leonie, additional, Robinson, Colette, additional, Janik, Katharine E, additional, Koper, Olga B, additional, Li, Ping, additional, Motamedi, Massoud, additional, Higgins, Daniel A, additional, Gadbury, Gary, additional, Zhu, Gaohong, additional, Troyer, Deryl L, additional, and Bossmann, Stefan H, additional

Published
2016
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32. Cell-delivered magnetic nanoparticles caused hyperthermia-mediated increased survival in a murine pancreatic cancer model

Author

Basel,Matthew T, Balivada,Sivasai, Wang,Hongwang, Shrestha,Tej B, Seo,Gwi Moon, Pyle,Marla, Ayabaweera,Gayani, Dani,Raj, Koper,Olga B, Tamura,Masaaki, Chikan,Viktor, Bossmann,Stefan H, Troyer,Deryl L, Basel,Matthew T, Balivada,Sivasai, Wang,Hongwang, Shrestha,Tej B, Seo,Gwi Moon, Pyle,Marla, Ayabaweera,Gayani, Dani,Raj, Koper,Olga B, Tamura,Masaaki, Chikan,Viktor, Bossmann,Stefan H, and Troyer,Deryl L

Abstract

Matthew T Basel1, Sivasai Balivada1, Hongwang Wang2, Tej B Shrestha1, Gwi Moon Seo1, Marla Pyle1, Gayani Abayaweera2, Raj Dani2, Olga B Koper2, Masaaki Tamura1, Viktor Chikan2, Stefan H Bossmann2, Deryl L Troyer11Department of Anatomy and Physiology, College of Veterinary Medicine, 2Department of Chemistry, Kansas State University, Manhattan, KS, USAAbstract: Using magnetic nanoparticles to absorb alternating magnetic field energy as a method of generating localized hyperthermia has been shown to be a potential cancer treatment. This report demonstrates a system that uses tumor homing cells to actively carry iron/iron oxide nanoparticles into tumor tissue for alternating magnetic field treatment. Paramagnetic iron/iron oxide nanoparticles were synthesized and loaded into RAW264.7 cells (mouse monocyte/macrophage-like cells), which have been shown to be tumor homing cells. A murine model of disseminated peritoneal pancreatic cancer was then generated by intraperitoneal injection of Pan02 cells. After tumor development, monocyte/macrophage-like cells loaded with iron/iron oxide nanoparticles were injected intraperitoneally and allowed to migrate into the tumor. Three days after injection, mice were exposed to an alternating magnetic field for 20 minutes to cause the cell-delivered nanoparticles to generate heat. This treatment regimen was repeated three times. A survival study demonstrated that this system can significantly increase survival in a murine pancreatic cancer model, with an average post-tumor insertion life expectancy increase of 31%. This system has the potential to become a useful method for specifically and actively delivering nanoparticles for local hyperthermia treatment of cancer.Keywords: cytotherapy, pancreatic cancer, disseminated peritoneal carcinomatosis, targeted magnetic hyperthermia, nanoparticles

Published
2012

37. Channel Blocking of MspA Revisited

Author

Perera, Ayomi S., primary, Wang, Hongwang, additional, Basel, Matthew T., additional, Pokhrel, Megh Raj, additional, Gamage, Pubudu Siyambalagoda, additional, Kalita, Mausam, additional, Wendel, Sebastian, additional, Sears, Bryan, additional, Welideniya, Dhanushi, additional, Liu, Yao, additional, Turro, Claudia, additional, Troyer, Deryl L., additional, and Bossmann, Stefan H., additional

Published
2012
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39. Magnetic-Fe/Fe3O4-nanoparticle-bound SN38 as carboxylesterase-cleavable prodrug for the delivery to tumors within monocytes/macrophages

Author

Wang, Hongwang, primary, Shrestha, Tej B, additional, Basel, Matthew T, additional, Dani, Raj Kumar, additional, Seo, Gwi-Moon, additional, Balivada, Sivasai, additional, Pyle, Marla M, additional, Prock, Heidy, additional, Koper, Olga B, additional, Thapa, Prem S, additional, Moore, David, additional, Li, Ping, additional, Chikan, Viktor, additional, Troyer, Deryl L, additional, and Bossmann, Stefan H, additional

Published
2012
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41. Human Xenografts Are Not Rejected in a Naturally Occurring Immunodeficient Porcine Line: A Human Tumor Model in Pigs

Author

Basel, Matthew T., primary, Balivada, Sivasai, additional, Beck, Amanda P., additional, Kerrigan, Maureen A., additional, Pyle, Marla M., additional, Dekkers, Jack C.M., additional, Wyatt, Carol R., additional, Rowland, Robert R.R., additional, Anderson, David E., additional, Bossmann, Stefan H., additional, and Troyer, Deryl L., additional

Published
2012
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48. Attenuation of Mouse Melanoma by A/C Magnetic Field after Delivery of Bi-Magnetic Nanoparticles by Neural Progenitor Cells

Author

Rachakatla, Raja Shekar, primary, Balivada, Sivasai, additional, Seo, Gwi-Moon, additional, Myers, Carl B., additional, Wang, Hongwang, additional, Samarakoon, Thilani N., additional, Dani, Raj, additional, Pyle, Marla, additional, Kroh, Franklin O., additional, Walker, Brandon, additional, Leaym, Xiaoxuan, additional, Koper, Olga B., additional, Chikan, Viktor, additional, Bossmann, Stefan H., additional, Tamura, Masaaki, additional, and Troyer, Deryl L., additional

Published
2010
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49. A/C magnetic hyperthermia of melanoma mediated by iron(0)/iron oxide core/shell magnetic nanoparticles: a mouse study

Author

Balivada, Sivasai, primary, Rachakatla, Raja Shekar, additional, Wang, Hongwang, additional, Samarakoon, Thilani N, additional, Dani, Raj Kumar, additional, Pyle, Marla, additional, Kroh, Franklin O, additional, Walker, Brandon, additional, Leaym, Xiaoxuan, additional, Koper, Olga B, additional, Tamura, Masaaki, additional, Chikan, Viktor, additional, Bossmann, Stefan H, additional, and Troyer, Deryl L, additional

Published
2010
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