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1. Ground electrical and electromagnetic methods for deep mineral exploration -- results from the SEEMS DEEP project

Author

Darnet, Mathieu, Kim, Bitnarae, Vedrine, Simon, Deparis, Jacques, Bretaudeau, Francois, Gance, Julien, Vermeersch, Fabrice, Truffert, Catherine, Autio, Uula, Kamm, Jochen, Patzer, Cedric, Kalscheuer, Thomas, and Heinonen, Suvi

Subjects
Physics - Geophysics
Abstract

The transition towards carbon neutral transportation and energy sources increases the global demand for mineral raw materials while easy-to-find near-surface (\< 200 m) ore deposits are unlikely discovered in well-explored areas such as Europe. In order to increase the mineral exploration success rate, the project SEEMS DEEP (SEismic and ElectroMagnetic methodS for DEEP mineral exploration) develops geophysical deep exploration workflow capable of imaging the bedrock from the surface down to several kilometres depth. In this paper, we present first results from ground electrical and electromagnetic surveys conducted at the SEEM DEEP geological test site, namely the Koillismaa Layered Intrusion Complex in north-eastern Finland. Here, a 1.7 km long hole drilled by GTK intersected mafic-ultramafic rocks with anomalous electrical and chargeability properties at ~1400 m depth, making it an interesting case study to test the ability of such technologies for imaging resistivity and chargeability contrasts at several kilometre depth.

Published
2024

6. How R4D projects interact with the SDGs: an analysis of the links between sustainable land use projects across the Global South and the SDG targets

Author

Albrecht Ehrensperger, Beatrice Adoyo, Ketema Bekele, Anne Dray, Mélanie Feurer, Micah Ingalls, Boniface Kiteme, Svitlana Lavrenciuc, Fideline Mboringong, John Richard Mbwambo, Nashr Fakhrizal, Tri Ngo Dung, Myriam Pham-Truffert, Mesmin Tchindjang, Harifidy Rakoto Rasimbola, Bruno Ramamonjisoa, Ana Maria Roldan Ortiz, Nwenwe Tun, Thoumthone Vongvisouk, and Julie G. Zaehringer

Subjects
2030 Agenda, competing claims, land use, research for development, SDG, synergies, trade-offs, Environmental sciences, GE1-350
Abstract

Abstract Non-technical summary Research for development (R4D) projects are designed to enhance the research community's contribution to implementation of the 2030 Agenda of the United Nations. We studied seven R4D projects that specifically addressed Sustainable Development Goal (SDG) 15 (life on land) in 14 contexts across Asia, Africa, and South America. We then analyzed how these projects interacted with other SDGs. Our findings reveal that the positive and negative interactions between project objectives and SDG targets vary significantly across contexts, highlighting the importance of considering local conditions when designing and implementing R4D initiatives. Technical summary We analyze how the objectives of research for development (R4D) projects that focus on a particular Sustainable Development Goal (SDG) – SDG 15 (life on land) – interact with the targets of other SDGs. We studied seven R4D projects in 14 contexts across Asia, Africa, and Latin America, comparing expert judgement of interactions between project objectives and SDG targets. Our findings indicate that the success of these projects depends largely on whether they are also working toward SDG targets other than those contained in SDG 15. In particular, working toward targets contained within SDGs on poverty, hunger, water, energy, production and consumption, and global partnerships – was often considered indivisible from the project objectives. Further, while all of the projects focused on SDG 15, our findings suggest that addressing only this goal is not sufficient. A range of other targets that were a priori not the immediate focus of the projects were revealed as ‘crucial’ to the project objectives across contexts. Finally, we list several implications, such as the need for policies to integrate local realities and the need for environmental R4D projects to adopt a holistic scope, particularly in terms of (a) securing social foundations, (b) building enabling institutions, and (c) negotiating competing claims on land. Social media summary What can we learn from land-related research for development projects and their links to the SDGs in concrete contexts?

Published
2024
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7. Recommendations for use of adhesives on hospitalized newborns: A systematic review of the literature

Author

Allen, Aurore, Audeoud, Frédérique, Bouvard, Charlotte, Brandicourt, Anne, Caeymaex, Laurence, Duboz, Marie Agnès, Evrard, Anne, Fichtner, Christine, Fischer-Fumeaux, Céline, Girard, Laurence, Gonnaud, Françoise, Hüppi, Petra, Knezovic, Nadine, Kuhn, Pierre, Laprugne-Garcia, Elisabeth, Legouais, Sophie, Mons, Fabienne, Muller, Jean-Baptiste, Picaud, Jean-Charles, Pierrat, Véronique, Pladys, Patrick, Reynaud, Audrey, Renesme, Laurent, Rideau, Aline, Sizun, Jacques, Souet, Gilles, Thiriez, Gérard, Tourneux, Pierre, Touzet, Marie, Truffert, Patrick, Tscherning, Charlotte, Zaoui, Catherine, Zana-Taieb, Elodie, Zores-Koenig, Claire, and Zana-Taïeb, Elodie

Published
2023
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8. L’enveloppement, l’habillage et les tissus en contact avec l’enfant en néonatologie

Author

Allen, A., Audeoud, F., Bouvard, C., Brandicourt, A., Caeymaex, L., Duboz, M.A., Evrard, A., Fichtner, C., Fischer-Fumeaux, C., Girard, L., Gonnaud, F., Hüppi, P., Knezovic, N., Kuhn, P., Laprugne-Garcia, E., Legouais, S., Mons, F., Muller, J.-B., Picaud, J.-C., Pierrat, V., Pladys, P., Reynaud, A., Renesme, L., Rideau, A., Sizun, J., Souet, G., Thiriez, G., Tourneux, P., Touzet, M., Truffert, P., Tscherning, C., Zaoui, C., Zana-Taieb, E., Zores-Koenig, C., Berne Audéoud, F., and Lenglemetz, S.L.

Published
2023
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15. Accès et rôle des parents en néonatalogie en période d’épidémie COVID-19 — Propositions du GREEN de la SFN

Author

Allen, A., Audeoud, F., Bouvard, C., Brandicourt, A., Caeymaex, L., Duboz, M.A., Evrard, A., Fichtner, C., Fischer-Fumeaux, C., Girard, L., Gonnaud, F., Hüppi, P., Knezovic, N., Kuhn, P., Laprugne-Garcia, E., Legouais, S., Mons, F., Muller, J.-B., Picaud, J.-C., Pierrat, V., Pladys, P., Reynaud, A., Renesme, L., Rideau, A., Sizun, J., Souet, G., Thiriez, G., Tourneux, P., Touzet, M., Truffert, P., Tscherning, C., Zaoui, C., Zana-Taieb, E., and Zores, C.

Published
2020
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17. Interactive visual syntheses for social-ecological systems understanding

Author

Martin, Dominic A., primary, Pham-Truffert, Myriam, additional, Gillham, Lara, additional, Andriamihaja, Onintsoa Ravaka, additional, Andriatsitohaina, R. Ntsiva N., additional, Diebold, Clara L., additional, Fulgence, Thio Rosin, additional, Kellner, Elke, additional, Llopis, Jorge Claudio, additional, Messerli, Peter, additional, Rakotomalala, Anjaharinony A. N. A., additional, Raveloaritiana, Estelle, additional, Wurz, Annemarie, additional, Zähringer, Julie G., additional, and Heinimann, Andreas, additional

Published
2024
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27. Impaired conduction of Ia sensory fibers in multifocal motor neuropathy: An electrophysiological demonstration

Author

Eglė Sukockienė, Michel R. Magistris, Ruxandra Iancu Ferfoglia, Agustina M. Lascano, and André Truffert

Subjects
H-reflex, Motor evoked potentials, Neurophysiology, Quadriceps combined technique (QCT), Transcranial magnetic stimulation, T-response, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Objectives: To report the clinical and electrophysiological findings in two patients with multifocal motor neuropathy (MMN) and bilateral absent patellar and Achilles tendon reflexes despite normal strength of quadriceps and calf muscles. Methods: The medical history and clinical evaluation were completed by electrophysiological tests: sensory and motor nerve conduction studies, needle electromyography, motor-evoked potentials (MEPs) after transcranial magnetic stimulation, patellar T (tendon) responses, quadriceps and soleus H (Hoffman) reflex recordings. Results: In the two patients, history, clinical evaluation, nerve conduction studies, favorable response to intravenous immunoglobulins, and positive anti-GM1 antibodies fulfilled the diagnosis of MMN. The lower limbs were asymptomatic, except for a unilateral weakness of foot dorsiflexion. The patellar and Achilles tendon reflexes disappeared during the course of the disease. The sensory nerve conduction studies were normal or minimally modified, M-wave and MEP/M amplitude ratio to the quadriceps were normal, patellar T (tendon) responses were virtually absent, and H-reflex to the quadriceps and soleus muscles were absent. Conclusions: These observations, which show the interruption of the reflex afferent pathway, raise the question of Ia afferent involvement in the lower limbs of these two patients with MMN. Further investigations should determine the frequency and significance of these findings in this disorder.

Published
2020
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28. Mortality and severe morbidity of very preterm infants: comparison of two French cohort studies

Author

Anais Godeluck, Patrick Gérardin, Victorine Lenclume, Corinne Mussard, Pierre-Yves Robillard, Sylvain Sampériz, Valérie Benhammou, Patrick Truffert, Pierre-Yves Ancel, and Duksha Ramful

Subjects
Preterm, Very low birth weight, Morbidity, Mortality, Bronchopulmonary dysplasia, Intraventricular haemorrhage, Pediatrics, RJ1-570
Abstract

Abstract Background In Reunion Island, a French overseas department, the burden of preterm birth and perinatal mortality exceed those observed in mainland France, despite similar access to standard perinatal care. The purpose of the study was to compare the outcome of two cohorts of NICU-admitted very preterm infants born between 24 and 31 weeks of gestation (WG): the registry-based OGP (Observatoire de la Grande Prématurité, Reunion Island, 2008–2013) cohort, and the nationwide EPIPAGE-2 (mainland France, 2011) observational cohort. Methods The primary outcome was adverse neonatal outcomes defined as a composite indicator of in-hospital mortality or any of three following severe morbidities: bronchopulmonary dysplasia (BPD), necrotising enterocolitis, or severe neurological injury (periventricular leukomalacia or grade III-IV intraventricular haemorrhages). Logistic regression modelling adjusting for confounders was performed. Results A total of 1272 very preterm infants from the Reunionese OGP cohort and 3669 peers from the mainland EPIPAGE-2 cohort were compared. Adverse neonatal outcomes were more likely observed in the OGP cohort (32.6% versus 26.6%, p

Published
2019
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30. Stochastic Formal Methods for Hybrid Systems

Author

Daumas, Marc, Lester, David, Martin-Dorel, Erik, and Truffert, Annick

Subjects
Computer Science - Mathematical Software
Abstract

We provide a framework to bound the probability that accumulated errors were never above a given threshold on hybrid systems. Such systems are used for example to model an aircraft or a nuclear power plant on one side and its software on the other side. This report contains simple formulas based on L\'evy's and Markov's inequalities and it presents a formal theory of random variables with a special focus on producing concrete results. We selected four very common applications that fit in our framework and cover the common practices of hybrid systems that evolve for a long time. We compute the number of bits that remain continuously significant in the first two applications with a probability of failure around one against a billion, where worst case analysis considers that no significant bit remains. We are using PVS as such formal tools force explicit statement of all hypotheses and prevent incorrect uses of theorems.

Published
2006

31. La famille dans les unités de médecine néonatale

Author

Allen, A., Audeoud, F., Bouvard, C., Brandicourt, A., Casper, C., Cayemaex, L., Denoual, H., Duboz, M.A., Evrard, A., Fichtner, C., Fischer-Fumeaux, C., Girard, L., Gonnaud, F., Haumont, D., Hüppi, P., Knezovic, N., Kuhn, P., Laprugne-Garcia, E., Legouais, S., Mons, F., Pelofy, V., Picaud, J.-C., Pierrat, V., Renaud, A., Renesme, L., Sizun, J., Souet, G., Thiriez, G., Tourneux, P., Touzet, M., Truffert, P., Zaoui, C., Zana-Taieb, E., Zores, C., and Reynaud, A.

Published
2018
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32. Le portage des nouveau-nés en peau à peau

Author

Allen, A., Audeoud, F., Bouvard, C., Brandicourt, A., Casper, C., Cayemaex, L., Denoual, H., Duboz, M.A., Evrard, A., Fichtner, C., Fischer-Fumeaux, C., Girard, L., Gonnaud, F., Haumont, D., Hüppi, P., Knezovic, N., Kuhn, P., Laprugne-Garcia, E., Legouais, S., Mons, F., Pelofy, V., Picaud, J.-C., Pierrat, V., Renaud, A., Renesme, L., Sizun, J., Souet, G., Thiriez, G., Tourneux, P., Touzet, M., Truffert, P., Zaoui, C., Zana-Taieb, E., Zores, C., and Zaoui-Grattepanche, C.

Published
2018
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33. Recommendation for hygiene and topical in neonatology from the French Neonatal Society

Author

Renesme, Laurent, Allen, A., Audeoud, F., Bouvard, C., Brandicourt, A., Casper, C., Cayemaex, L., Denoual, H., Duboz, M. A., Evrard, A., Fichtner, C., Fischer-Fumeaux, C. J., Girard, L., Gonnaud, F., Haumont, D., Hüppi, P., Knezovic, N., Laprugne-Garcia, E., Legouais, S., Mons, F., Pelofy, V., Picaud, J. C., Pierrat, V., Pladys, P., Reynaud, A., Souet, G., Thiriez, G., Tourneux, P., Touzet, M., Truffert, P., Zaoui, C., Zana-Taieb, E., Zores, C., Sizun, J., and Kuhn, P.

Published
2019
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34. Early advance care planning in amyotrophic lateral sclerosis patients: results of a systematic intervention by a palliative care team in a multidisciplinary management programme – a 4-year cohort study

Author

Eglė Sukockienė, Ruxandra Iancu-Ferfoglia, Monique Boegli, Catherine Lefranc-Barranco, André Truffert, Anne-Chantal Héritier-Barras, Laurence Genton, Igor Leuchter, Dan Adler, Jean-Paul Janssens, and Monica Escher

Subjects
motor neuron disease, palliative care, advance care planning, amyotrophic lateral sclerosis, advance directives, Medicine
Abstract

INTRODUCTION Although recommended, the implementation of early advance care planning is suboptimal in amyotrophic lateral sclerosis (ALS) patients. Barriers to advance care planning include healthcare professionals’ and patients’ reluctance, and uncertainty about the right time to initiate a discussion. AIM OF THE STUDY To determine how often advance care planning was initiated, and the content of the discussion in a first routine palliative care consultation integrated within a multidisciplinary management programme. METHODS Between June 2012 and September 2016, a prospective cohort study was conducted in Geneva University Hospitals. Sixty-eight patients were seen every 3 months for a 1-day clinical evaluation in a day care centre. RESULTS The patients’ mean ± standard deviation age was 68.6 ± 11.9 years, 50% were women. Four patients were excluded because of dementia. Advance care planning was initiated with 49 (77%) patients in the first palliative care consultation. Interventions most often addressed were cardiopulmonary resuscitation (49%), intubation and tracheostomy (47%) and palliative sedation (36.7%). Assisted suicide was discussed with 16 patients (36.6%). Functional disability was the only factor associated with initiation of advance care planning. Nearly half of the patients wrote advance directives (45%) or designated a healthcare surrogate (41%). Bulbar onset, functional disability and noninvasive ventilation were not associated with the completion of advance directives. CONCLUSION Early initiation of advance care planning is feasible in most ALS patients during a routine consultation, and relevant treatment issues can be discussed. All ALS patients should be offered the opportunity to write advance directives as completion was not associated with disease severity. (Registered at clinicaltrials.gov: No. NCT03536962.)

Published
2021
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36. Sporadic late onset nemaline myopathy with monoclonal gammopathy of undetermined significance: two cases with long term stability

Author

André Truffert, Ruxandra Iancu Ferfoglia, Johannes Alexander Lobrinus, Kaveh Samii, and André Kohler

Subjects
sporadic late-onset nemaline myopathy, monoclonal gammopathy of undetermined significance, stem cell transplantation, lenalidomide, Medicine, Human anatomy, QM1-695
Abstract

Monoclonal gammopathy of undetermined significance (MGUS) associated to sporadic late onset nemaline myopathy (SLONM) is a rare and severely disabling condition of quickly progressive limb girdle acquired myopathy. It is believed by some authors to be due to myotoxicity of light chain deposits. Two female patients were diagnosed with MGUS associated SLONM. In the first case, diagnosis was delayed by 6 years thus giving time for a severe generalized myopathy and cardiomyopathy to develop. A single anti-myeloma chemotherapy with lenalidomide markedly improved and stabilized the patient’s condition despite respiratory and cardiac insufficiency. In our second patient the condition was identified one year after onset of the first symptom and markedly improved after autologous bone marrow transplantation and lenalidomide. Clinicians should be aware of monoclonal gammopathy associated sporadic late onset nemaline myopathy as this acquired muscle disorder, although extremely rare, may be reversed by adequate management.

Published
2020
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37. Multidisciplinary care in amyotrophic lateral sclerosis: a 4-year longitudinal observational study

Author

Eglė Sukockienė, Ruxandra Iancu Ferfoglia, André Truffert, Anne-Chantal Héritier Barras, Laurence Genton, Valérie Viatte, Igor Leuchter, Monica Escher, Ninon Horie, Antoine Poncet, Patrick Pasquina, Dan Adler, and Jean-Paul Janssens

Subjects
amyotrophic lateral sclerosis, multidisciplinary management, Survival, Noninvasive ventilation, percutaneous gastrostomy, Medicine
Published
2020
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40. Validation of imaging benefits of dual monopole exposures

Author

Brunner, Timothy A., primary, Franke, Joern-Holger, additional, Truffert, Vincent, additional, De Bisschop, Peter, additional, Rispens, Gijsbert, additional, Duriau, Edouard, additional, van Dijk, Andre, additional, Tabery, Cyrus E., additional, Rio, David, additional, De Poortere, Etienne P., additional, van de Kerkhof, Mark A., additional, and Hendrickx, Eric, additional

Published
2023
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43. Circumstances, causes and timing of death in extremely preterm infants admitted to NICU: The EPIPAGE‐2 study

Author

Boileau, Pascal, primary, Letouzey, Mathilde, additional, Morgan, Andrei S., additional, Lorthe, Elsa, additional, Kaminski, Monique, additional, Coquelin, Anaëlle, additional, Azria, Elie, additional, Caeymaex, Laurence, additional, Rouget, Florence, additional, Diguisto, Caroline, additional, Claris, Olivier, additional, Tosello, Barthélémy, additional, Truffert, Patrick, additional, Bétrémieux, Pierre, additional, Benhammou, Valérie, additional, Marchand‐Martin, Laetitia, additional, Goffinet, François, additional, Ancel, Pierre‐Yves, additional, and Foix‐L'Hélias, Laurence, additional

Published
2023
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45. Perception des parents de leur participation aux soins de leur enfant dans les unités de néonatologie en France

Author

Allen, A., Brandicourt, A., Duboz, M.-A., Fichtner, C., Girard, L., Gonnaud, F., Haumont, D., Hüppi, P., Isaia, S., Knezovic, N., Legouais, S., Mons, F., Pelofy, V., Picaud, J.-C., Pierrat, V., Renesme, L., Sizun, J., Souet, G., Thiriez, G., Truffert, P., Zaoui, C., Zores, C., Casper, C., Caeymaex, L., Dicky, O., Akrich, M., Reynaud, A., Bouvard, C., Evrard, A., and Kuhn, P.

Published
2016
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46. Effect of Intra- and Extrauterine Growth on Long-Term Neurologic Outcomes of Very Preterm Infants

Author

Larroque, B., Ancel, P.Y., Blondel, B., Bréart, G., Dehan, M., Garel, M., Kaminski, M., Maillard, F., du Mazaubrun, C., Missy, P., Sehili, F., Supernant, K., Marchand, L., Durand, M., Matis, J., Messer, J., Treisser, A., Burguet, A., Abraham-Lerat, L., Menget, A., Roth, P., Schaal, J.-P., Thiriez, G., Leveque, C., Marret, S., Marpeau, L., Boulot, P., Cambonie, G., Picaud, J.-C., Donadio, A.M., Ledesert, B., André, M., Fresson, J., Hascoët, J.M., Arnaud, C., Grandjean, H., Rolland, M., Fily, A., Ego, A., Outtier, M.L., Pierrat, V., Subtil, D., Truffert, P., Boog, G., Rouger-Bureau, V., Rozé, J.-C., Zupan-Simunek, V., Vodovar, M., Voyer, M., Guellec, Isabelle, Lapillonne, Alexandre, Marret, Stephane, Picaud, Jean-Charles, Mitanchez, Delphine, Charkaluk, Marie-Laure, Fresson, Jeanne, Arnaud, Catherine, Flamand, Cyril, Cambonie, Gilles, Kaminski, Monique, Roze, Jean-Christophe, and Ancel, Pierre-Yves

Published
2016
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47. Admission Hypothermia in Very Preterm Infants and Neonatal Mortality and Morbidity

Author

Van Reempts, Patrick, Martens, Evelyne, Martens, Guy, Pryds, Ole, Boerch, Klaus, Hasselager, Asbjoern, Huusom, Lene, Weber, Tom, Toome, Liis, Varendi, Heili, Truffert, Patrick, Jarreau, Pierre-Henri, Ancel, Pierre-Yves, Blondel, Beatrice, Burguet, Antoine, Schmidt, Stephan, Gortner, Ludwig, Cuttini, Marina, Croci, Ileana, Baronciani, Dante, Gargano, Giancarlo, Carnielli, Virgilio, Di Lallo, Domenico, Agostino, Rocco, Franco, Francesco, Koopman-Esseboom, Corine, Nijman, Joppe, van Heijst, Arno, Gadzinowski, Janusz, Mazela, Jan, Graça, Luis M., Ceu Machado, Maria, Carapato, Rui, Barros, Henrique, Rodrigues, Carina, Rodrigues, Teresa, Draper, Elizabeth, Boyle, Elaine M., Manktelow, Brad, Milligan, David W.A., Fenton, Alan, Wilson, Emilija, Maier, Rolf F., Norman, Mikael, Misselwitz, Bjoern, Howell, Elizabeth A., Zeitlin, Jennifer, and Bonamy, Anna-Karin

Published
2016
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49. Machine Learning on Multiplexed Optical Metrology Pattern Shift Response Targets to Predict Electrical Properties.

Author

Ashby, Thomas J., Truffert, Vincent, Cerbu, Dorin, Ausschnitt, Kit, Charley, Anne-Laure, Verachtert, Wilfried, and Wuyts, Roel

Subjects
*STIMULUS & response (Psychology), *METROLOGY, *PREDICTION models, *MACHINE learning, *SEMICONDUCTOR devices, *OPTICAL sensors
Abstract

Doing high throughput high accuracy metrology in small geometries is challenging. One approach is to build easily measurable proxy targets onto dies and make a predictive model based on those signals. We use optical Pattern Shift Response (PSR) proxy targets to build predictive models of the electrical characteristics of devices in the Back End Of Line (BEOL). Given the wide choice of PSR targets, we explore how to select combinations of them to maximise the utility of the features for building an accurate Machine Learning (ML) model; we call this approach Multiplexed Optical Metrology. We also explore the trade-off between chip area dedicated to targets and achievable accuracy. We run ML experiments using different selections of targets measured at different stages of BEOL processing: post-lithography and post-Chemical-Mechanical-Planarisation (CMP). Our results show that a) reasonable predictive performance can be achieved for a reasonable area budget; b) ML model performance across target families varies significantly, thus justifying the need for careful selection of targets; c) longitudinal measurements of targets increases accuracy for no extra area penalty; d) increasing the number of targets gives some improvement in accuracy for a dataset of this size, but relatively small compared to the increase in area budget needed. Ultimately we aim to do die-level yield prediction using these techniques. We discuss how collecting a larger dataset with appropriate yield information is the logical next step to achieving this. [ABSTRACT FROM AUTHOR]

Published
2024
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50. Neurodevelopment and healthcare utilisation at age 5--6 years in bronchopulmonary dysplasia: an EPIPAGE- 2 cohort study.

Author

Tréluyer, Ludovic, Nuytten, Alexandra, Guellec, Isabelle, Jarreau, Pierre-Henri, Benhammou, Valérie, Cambonie, Gilles, Truffert, Patrick, Marchand-Martin, Laetitia, Ancel, Pierre Yves, and Torchin, Héloïse

Subjects
BRONCHOPULMONARY dysplasia, MENSTRUATION disorders, LOW birth weight, VERY low birth weight, WECHSLER Intelligence Scale for Children, MEDICAL care, PATENT ductus arteriosus
Published
2024
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