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9 results on '"Truman, Kyla A."'

2. Intratumoral drug-releasing microdevices allow in situ high-throughput pharmaco phenotyping in patients with gliomas

Author

Peruzzi, Pierpaolo, primary, Dominas, Christine, additional, Fell, Geoffrey, additional, Bernstock, Joshua D., additional, Blitz, Sarah, additional, Mazzetti, Debora, additional, Zdioruk, Mykola, additional, Dawood, Hassan Y., additional, Triggs, Daniel V., additional, Ahn, Sebastian W., additional, Bhagavatula, Sharath K., additional, Davidson, Shawn M., additional, Tatarova, Zuzana, additional, Pannell, Michael, additional, Truman, Kyla, additional, Ball, Anna, additional, Gold, Maxwell P., additional, Pister, Veronika, additional, Fraenkel, Ernest, additional, Chiocca, E. Antonio, additional, Ligon, Keith L., additional, Wen, Patrick Y., additional, and Jonas, Oliver, additional

Published
2023
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3. Intracranial, intratumoral implantation of drug-releasing microdevices in patients with high grade gliomas is feasible, safe, and may predict tumor response to systemic chemotherapy

Author

Peruzzi, Pierpaolo, primary, Dominas, Christine, additional, Fell, Geoffrey, additional, Blitz, Sarah, additional, Bernstock, Joshua, additional, Dawood, Hassan, additional, Triggs, Daniel, additional, Ahn, Sebastian, additional, Bhagavatula, Sharat, additional, Tatarova, Zuzana, additional, Pannel, Michael, additional, Truman, Kyla, additional, Ball, Anna, additional, Chiocca, E., additional, Ligon, Keith, additional, Wen, Patrick, additional, and Jonas, Oliver, additional

Published
2022
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4. Combined immunotherapy with controlled interleukin-12 gene therapy and immune checkpoint blockade in recurrent glioblastoma: An open-label, multi-institutional phase I trial

Author

Chiocca, E Antonio, primary, Gelb, Arnold B, additional, Chen, Clark C, additional, Rao, Ganesh, additional, Reardon, David A, additional, Wen, Patrick Y, additional, Bi, Wenya Linda, additional, Peruzzi, Pierpaolo, additional, Amidei, Christina, additional, Triggs, Dan, additional, Seften, Leah, additional, Park, Grace, additional, Grant, James, additional, Truman, Kyla, additional, Buck, Jill Y, additional, Hadar, Nira, additional, Demars, Nathan, additional, Miao, John, additional, Estupinan, Taylor, additional, Loewy, John, additional, Chadha, Kamal, additional, Tringali, Joseph, additional, Cooper, Laurence, additional, and Lukas, Rimas V, additional

Published
2021
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6. Combined immunotherapy with controlled interleukin-12 gene therapy and immune checkpoint blockade in recurrent glioblastoma: An open-label, multi-institutional phase I trial.

Author

Chiocca, E Antonio, Gelb, Arnold B, Chen, Clark C, Rao, Ganesh, Reardon, David A, Wen, Patrick Y, Bi, Wenya Linda, Peruzzi, Pierpaolo, Amidei, Christina, Triggs, Dan, Seften, Leah, Park, Grace, Grant, James, Truman, Kyla, Buck, Jill Y, Hadar, Nira, Demars, Nathan, Miao, John, Estupinan, Taylor, and Loewy, John

Published
2022
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7. Decreased Incidence of CSF Leaks after Skull Base Fractures in the 21st Century: An Institutional Report.

Author

Stopa, Brittany M., Leyva, Oscar A., Harper, Cierra N., Truman, Kyla A., Corrales, C. Eduardo, Smith, Timothy R., and Gormley, William B.

Subjects
RHINORRHEA, CEREBROSPINAL fluid leak, SKULL base, SKULL fractures, CEREBROSPINAL fluid rhinorrhea, TWENTY-first century
Abstract

Objectives  Cerebrospinal fluid (CSF) leaks are a possible complication in patients with skull base fractures (SBFs). The widely cited incidence of CSF leaks is 10 to 30% in SBF patients; however, this estimate is based only on a few outdated studies. A recent report found CSF leaks in <2% SBF patients, suggesting the incidence may be lower now. To investigate this, we report here our institutional series. Design  This study is a retrospective chart review. Setting  The study was conducted at two major academic medical centers (2000–2018). Participants  Adult patients with SBF were included in this study. Main Outcome Measures  Variables included age, gender, CSF leak within 90 days, management regimen, meningitis within 90 days, and 1-year mortality. Results  Among 4,944 patients with SBF, 199 (4%) developed a CSF leak. SBF incidence was positively correlated with year of clinical presentation (r -squared 0.78, p  < 0.001). Among CSF leaks, 42% were conservatively managed, 52% were treated with lumbar drain, and 7% required surgical repair. Meningitis developed in 28% CSF leak patients. The 1-year mortality for all SBF patients was 11%, for patients with CSF leaks was 12%, and for patients with meningitis was 16%. Conclusion  In the largest institutional review of SBF patients in the 21st century, we found CSF leak incidence to be 4%. This is lower than the widely cited range of 10 to 30%. Nevertheless, morbidity and mortality associated with this complication remains clinically significant, and SBF patients should continue to be monitored for CSF leaks. We provide here our institutional treatment algorithm for these patients that may help to inform the treatment strategy at other institutions. [ABSTRACT FROM AUTHOR]

Published
2022
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