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748 results on '"Tsai, Ying-Huang"'

1. Benefit of dual bronchodilator therapy on exacerbations in former and current smokers with chronic obstructive pulmonary disease in real-world clinical practice: a multicenter validation study (TOReTO)

Author

Lai, Yu-Ting, Tsai, Ying-Huang, Hsieh, Meng-Jer, Chen, Ning-Hung, Cheng, Shih-Lung, Tao, Chi-Wei, Wei, Yu-Feng, Wu, Yao-Kuang, Chan, Ming-Cheng, Liu, Shih-Feng, Hsu, Wu-Huei, Yang, Tsung-Ming, Liu, Ching-Lung, Kuo, Ping-Hung, and Lin, Ming-Shian

Published
2024
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3. Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Author

Shi, Jianxin, Shiraishi, Kouya, Choi, Jiyeon, Matsuo, Keitaro, Chen, Tzu-Yu, Dai, Juncheng, Hung, Rayjean J, Chen, Kexin, Shu, Xiao-Ou, Kim, Young Tae, Landi, Maria Teresa, Lin, Dongxin, Zheng, Wei, Yin, Zhihua, Zhou, Baosen, Song, Bao, Wang, Jiucun, Seow, Wei Jie, Song, Lei, Chang, I-Shou, Hu, Wei, Chien, Li-Hsin, Cai, Qiuyin, Hong, Yun-Chul, Kim, Hee Nam, Wu, Yi-Long, Wong, Maria Pik, Richardson, Brian Douglas, Funderburk, Karen M, Li, Shilan, Zhang, Tongwu, Breeze, Charles, Wang, Zhaoming, Blechter, Batel, Bassig, Bryan A, Kim, Jin Hee, Albanes, Demetrius, Wong, Jason YY, Shin, Min-Ho, Chung, Lap Ping, Yang, Yang, An, She-Juan, Zheng, Hong, Yatabe, Yasushi, Zhang, Xu-Chao, Kim, Young-Chul, Caporaso, Neil E, Chang, Jiang, Ho, James Chung Man, Kubo, Michiaki, Daigo, Yataro, Song, Minsun, Momozawa, Yukihide, Kamatani, Yoichiro, Kobayashi, Masashi, Okubo, Kenichi, Honda, Takayuki, Hosgood, Dean H, Kunitoh, Hideo, Patel, Harsh, Watanabe, Shun-ichi, Miyagi, Yohei, Nakayama, Haruhiko, Matsumoto, Shingo, Horinouchi, Hidehito, Tsuboi, Masahiro, Hamamoto, Ryuji, Goto, Koichi, Ohe, Yuichiro, Takahashi, Atsushi, Goto, Akiteru, Minamiya, Yoshihiro, Hara, Megumi, Nishida, Yuichiro, Takeuchi, Kenji, Wakai, Kenji, Matsuda, Koichi, Murakami, Yoshinori, Shimizu, Kimihiro, Suzuki, Hiroyuki, Saito, Motonobu, Ohtaki, Yoichi, Tanaka, Kazumi, Wu, Tangchun, Wei, Fusheng, Dai, Hongji, Machiela, Mitchell J, Su, Jian, Kim, Yeul Hong, Oh, In-Jae, Lee, Victor Ho Fun, Chang, Gee-Chen, Tsai, Ying-Huang, Chen, Kuan-Yu, Huang, Ming-Shyan, Su, Wu-Chou, Chen, Yuh-Min, Seow, Adeline, Park, Jae Yong, and Kweon, Sun-Seog

Subjects
Genetics, Cancer, Clinical Research, Human Genome, Prevention, Lung, Lung Cancer, Tobacco, Tobacco Smoke and Health, 2.1 Biological and endogenous factors, Aetiology, Respiratory, Humans, Genome-Wide Association Study, Genetic Predisposition to Disease, Adenocarcinoma of Lung, Asia, Eastern, Lung Neoplasms, Polymorphism, Single Nucleotide
Abstract

Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (Pinteraction = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications.

Published
2023

4. Low-dose CT screening among never-smokers with or without a family history of lung cancer in Taiwan: a prospective cohort study

Author

Chan, Chang-Chuan, Chan, Si-Wa, Chang, I-Shou, Chang, Jer-Hwa, Chao, Kun-San, Chen, Chi-Jen, Chen, Huei-Wen, Chiang, Chun-Ju, Chiou, Hung-Yi, Chou, Mei-Chun, Chung, Chi-Li, Chung, Ta-Jung, Guo, Yue Leon, Hsiao, Chin-Fu, Huang, Chien-Sheng, Ko, Sheung-Fat, Lee, Mei-Hsuan, Li, Yao-Jen, Liao, Yu-San, Lu, Yueh-Hsun, Ou, Hsin-You, Wu, Ping-An, Yang, Hwai-I, Yang, Shi-Yi, Yang, Szu-Chun, Chang, Gee-Chen, Chiu, Chao-Hua, Yu, Chong-Jen, Chang, Yeun-Chung, Chang, Ya-Hsuan, Hsu, Kuo-Hsuan, Wu, Yu-Chung, Chen, Chih-Yi, Hsu, Hsian-He, Wu, Ming-Ting, Yang, Cheng-Ta, Chong, Inn-Wen, Lin, Yu-Ching, Hsia, Te-Chun, Lin, Meng-Chih, Su, Wu-Chou, Lin, Chih-Bin, Lee, Kang-Yun, Wei, Yu-Feng, Lan, Gong-Yau, Chan, Wing P, Wang, Kao-Lun, Wu, Mei-Han, Tsai, Hao-Hung, Chian, Chih-Feng, Lai, Ruay-Sheng, Shih, Jin-Yuan, Wang, Chi-Liang, Hsu, Jui-Sheng, Chen, Kun-Chieh, Chen, Chun-Ku, Hsia, Jiun-Yi, Peng, Chung-Kan, Tang, En-Kuei, Hsu, Chia-Lin, Chou, Teh-Ying, Shen, Wei-Chih, Tsai, Ying-Huang, Tsai, Chun-Ming, Chen, Yuh-Min, Lee, Yu-Chin, Chen, Hsuan-Yu, Yu, Sung-Liang, Chen, Chien-Jen, Wan, Yung-Liang, Hsiung, Chao Agnes, and Yang, Pan-Chyr

Published
2024
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5. Serum vascular endothelial growth factor affects tissue fluid accumulation and is associated with deteriorating tissue perfusion and oxygenation in severe sepsis: a prospective observational study

Author

Lin, Chin-Kuo, Tsai, Ying-Huang, Kao, Kuo-Chin, Lin, Chieh-Mo, Zhou, Shao-Kui, Ho, Meng-Chin, Huang, Shu-Yi, Fang, Yu-Hung, Chang, Che-Chia, Lee, Wei-Chun, Lee, Yueh-Lin, Chen, Min-Chi, Hsieh, Meng-Jer, Lin, Yu-Ching, Hung, Ming-Szu, Kuo, Wen-Chun, and Lin, Bor-Shyh

Published
2023
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6. Low-Dose Computed Tomography Screening in Relatives With a Family History of Lung Cancer

Author

Wang, Chi-Liang, Hsu, Kuo-Hsuan, Chang, Ya-Hsuan, Ho, Chao-Chi, Chiang, Chun-Ju, Chen, Kun-Chieh, Cheung, Yun-Chung, Huang, Pei-Ching, Chen, Yu-Ruei, Chen, Chih-Yi, Hsu, Chung-Ping, Hsia, Jiun-Yi, Chen, Hsuan-Yu, Yang, Shi-Yi, Li, Yao-Jen, Yang, Tsung-Ying, Tseng, Jeng-Sen, Chuang, Cheng-Yen, Hsiung, Chao A., Chen, Yuh-Min, Huang, Ming-Shyan, Yu, Chong-Jen, Chen, Kuan-Yu, Su, Wu-Chou, Chen, Jeremy J.W., Yu, Sung-Liang, Chen, Chien-Jen, Yang, Pan-Chyr, Tsai, Ying-Huang, and Chang, Gee-Chen

Published
2023
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8. Sub-multiplicative interaction between polygenic risk score and household coal use in relation to lung adenocarcinoma among never-smoking women in Asia

Author

Blechter, Batel, Wong, Jason Y.Y., Agnes Hsiung, Chao, Hosgood, H.Dean, Yin, Zhihua, Shu, Xiao-Ou, Zhang, Han, Shi, Jianxin, Song, Lei, Song, Minsun, Zheng, Wei, Wang, Zhaoming, Caporaso, Neil, Burdette, Laurie, Yeager, Meredith, Berndt, Sonja I., Teresa Landi, Maria, Chen, Chien-Jen, Chang, Gee-Chen, Hsiao, Chin-Fu, Tsai, Ying-Huang, Chen, Kuan-Yu, Huang, Ming-Shyan, Su, Wu-Chou, Chen, Yuh-Min, Chien, Li-Hsin, Chen, Chung-Hsing, Yang, Tsung-Ying, Wang, Chih-Liang, Hung, Jen-Yu, Lin, Chien-Chung, Perng, Reury-Perng, Chen, Chih-Yi, Chen, Kun-Chieh, Li, Yao-Jen, Yu, Chong-Jen, Chen, Yi-Song, Chen, Ying-Hsiang, Tsai, Fang-Yu, Jie Seow, Wei, Bassig, Bryan A., Hu, Wei, Ji, Bu-Tian, Wu, Wei, Guan, Peng, He, Qincheng, Gao, Yu-Tang, Cai, Qiuyin, Chow, Wong-Ho, Xiang, Yong-Bing, Lin, Dongxin, Wu, Chen, Wu, Yi-Long, Shin, Min-Ho, Hong, Yun-Chul, Matsuo, Keitaro, Chen, Kexin, Pik Wong, Maria, Lu, Daru, Jin, Li, Wang, Jiu-Cun, Seow, Adeline, Wu, Tangchun, Shen, Hongbing, Fraumeni, Joseph F., Yang, Pan-Chyr, Chang, I-Shou, Zhou, Baosen, Chanock, Stephen J., Rothman, Nathaniel, Chatterjee, Nilanjan, and Lan, Qing

Published
2021
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9. Associations Between Severe Influenza‐Complicated Thromboembolism Events, Intensive Care Unit Stays and Mortality, and Associated Risk Factors: A Retrospective Cohort Study.

Author

Lee, Wei‐Chun, Chang, Che‐Chia, Ho, Meng‐Chin, Lin, Chin‐Kuo, Lin, Chieh‐Mo, Fang, Yu‐Hung, Huang, Shu‐Yi, Lin, Yu‐Ching, Chuang, Min‐Chun, Yang, Tsung‐Ming, Hung, Ming‐Szu, Chou, Yen‐Li, Tsai, Ying‐Huang, and Hsieh, Meng‐Jer

Subjects
VENOUS thrombosis, MORTALITY risk factors, INTENSIVE care units, DISEASE risk factors, LOGISTIC regression analysis
Abstract

The association between influenza infection and thromboembolism (TE) events, including cardiovascular events, cerebrovascular events, pulmonary embolism, and deep vein thrombosis, is supported by compelling evidence. However, there is a disparity in the risk factors that impact the outcomes of severe influenza‐complicated TE in intensive care unit (ICU) patients. The objective of this study was to evaluate the outcomes of severe influenza‐complicated TE in ICU patients and identify any associated risk factors. Methods: A retrospective cohort study was conducted, recruiting consecutive patients with TE events admitted to the ICU between December 2015 through December 2018 at our institution in Taiwan. The study included a group of 108 patients with severe influenza and a control group of 192 patients with severe community‐acquired pneumonia. Associations between complicated TE, length of ICU stay, and 90‐day mortality were evaluated using logistic regression analysis, and risk factors were identified using univariate and multivariate generalized linear regression analyses. Results: TE event prevalence was significantly higher in ICU patients with severe influenza than in ICU patients with severe CAP (21.3% vs. 5.7%, respectively; p < 0.05). Patients with severe influenza who developed TE experienced a significant increase in the ratio of mechanical ventilation use, length of mechanical ventilation use, ICU stay, and 90‐day mortality when compared to patients without TE (all p < 0.05). The comparison of severe CAP patients with and without TE revealed no significant differences (p > 0.05). The development of thromboembolic events in patients with severe influenza or severe noninfluenza CAP is linked to influenza infection and hypertension (p < 0.05). Furthermore, complicated TE and the severity of the APACHE II score are risk factors for 90‐day mortality in ICU patients with severe influenza (p < 0.05). Conclusions: Patients with severe influenza and complicated TE are more likely to have an extended ICU stay and 90‐day mortality than patients with severe CAP. The risk is significantly higher for patients with a higher APACHE II score. The results of this study may aid in defining better strategies for early recognition and prevention of severe influenza‐complicated TE. [ABSTRACT FROM AUTHOR]

Published
2024
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10. IL-6 and TIMP-1 Correlated to Airway Pathogen Colonization and Predict Disease Severity in Patients with Non-Cystic Fibrosis Bronchiectasis.

Author

Lin, Horng-Chyuan, Hsieh, Meng-heng, Lo, Yu-Lun, Huang, Hung-Yu, Huang, Shih-Wei, Huang, Chien-Da, Chang, Po-Jui, Lo, Chun-Yu, Lin, Ting-Yu, Fang, Yueh-Fu, Lin, Shu-Min, Lin, Chun-Yu, and Tsai, Ying-Huang

Subjects
FUNGAL cultures, BACTERIAL cultures, BRONCHIECTASIS, INTERLEUKIN-6, SPUTUM, FIBROSIS
Abstract

Background: Non-cystic fibrosis bronchiectasis is associated with airway pathogen colonization. We planned to investigate the inflammatory markers in patients with different airway pathogens and their correlation with disease severity. Methods: We enrolled patients aged between 20 and 75 from October 2021 to August 2022. All patients had sputum evaluation for bacterial and fungal cultures before enrollment, and were classified into four groups according to the culture results. Results: Forty-four patients with non-CF bronchiectasis and six controls were enrolled and categorized as follows: Group 1, no pathogens identified in sputum cultures (n = 14); Group 2, positive fungal culture results (n = 18); Group 3, positive P. aeruginosa culture results (n = 7); and Group 4, positive culture results for both fungi and P. aeruginosa (n = 5). Group 4 had significantly higher serum defensin α 1, IL-6 and tissue inhibitors of MMP (TIMP)-1 levels than group 1 patients. The serum levels of IL-6 and TIMP-1 were positively correlated with the FACED score and negatively correlated with distance-saturation product. Conclusion: Significantly higher levels of serum IL-6 and TIMP-1 were found in the patients who had concomitant fungal and P. aeruginosa colonization, and were closely related to clinical severity and may have important roles in disease monitoring. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women

Author

Wong, Jason Y.Y., Zhang, Han, Hsiung, Chao A., Shiraishi, Kouya, Yu, Kai, Matsuo, Keitaro, Wong, Maria Pik, Hong, Yun-Chul, Wang, Jiucun, Seow, Wei Jie, Wang, Zhaoming, Song, Minsun, Kim, Hee Nam, Chang, I-Shou, Chatterjee, Nilanjan, Hu, Wei, Wu, Chen, Mitsudomi, Tetsuya, Zheng, Wei, Kim, Jin Hee, Seow, Adeline, Caporaso, Neil E., Shin, Min-Ho, Chung, Lap Ping, An, She-Juan, Wang, Ping, Yang, Yang, Zheng, Hong, Yatabe, Yasushi, Zhang, Xu-Chao, Kim, Young Tae, Cai, Qiuyin, Yin, Zhihua, Kim, Young-Chul, Bassig, Bryan A., Chang, Jiang, Ho, James Chung Man, Ji, Bu-Tian, Daigo, Yataro, Ito, Hidemi, Momozawa, Yukihide, Ashikawa, Kyota, Kamatani, Yoichiro, Honda, Takayuki, Hosgood, H. Dean, Sakamoto, Hiromi, Kunitoh, Hideo, Tsuta, Koji, Watanabe, Shun-ichi, Kubo, Michiaki, Miyagi, Yohei, Nakayama, Haruhiko, Matsumoto, Shingo, Tsuboi, Masahiro, Goto, Koichi, Shi, Jianxin, Song, Lei, Hua, Xing, Takahashi, Atsushi, Goto, Akiteru, Minamiya, Yoshihiro, Shimizu, Kimihiro, Tanaka, Kazumi, Wei, Fusheng, Matsuda, Fumihiko, Su, Jian, Kim, Yeul Hong, Oh, In-Jae, Song, Fengju, Su, Wu-Chou, Chen, Yu-Min, Chang, Gee-Chen, Chen, Kuan-Yu, Huang, Ming-Shyan, Chien, Li-Hsin, Xiang, Yong-Bing, Park, Jae Yong, Kweon, Sun-Seog, Chen, Chien-Jen, Lee, Kyoung-Mu, Blechter, Batel, Li, Haixin, Gao, Yu-Tang, Qian, Biyun, Lu, Daru, Liu, Jianjun, Jeon, Hyo-Sung, Hsiao, Chin-Fu, Sung, Jae Sook, Tsai, Ying-Huang, Jung, Yoo Jin, Guo, Huan, Hu, Zhibin, Wang, Wen-Chang, Chung, Charles C., Burdett, Laurie, Yeager, Meredith, Hutchinson, Amy, Berndt, Sonja I., Wu, Wei, Pang, Herbert, Li, Yuqing, Choi, Jin Eun, Park, Kyong Hwa, Sung, Sook Whan, Liu, Li, Kang, C.H., Zhu, Meng, Chen, Chung-Hsing, Yang, Tsung-Ying, Xu, Jun, Guan, Peng, Tan, Wen, Wang, Chih-Liang, Hsin, Michael, Sit, Ko-Yung, Ho, James, Chen, Ying, Choi, Yi Young, Hung, Jen-Yu, Kim, Jun Suk, Yoon, Ho Il, Lin, Chien-Chung, Park, In Kyu, Xu, Ping, Wang, Yuzhuo, He, Qincheng, Perng, Reury-Perng, Chen, Chih-Yi, Vermeulen, Roel, Wu, Junjie, Lim, Wei-Yen, Chen, Kun-Chieh, Li, Yao-Jen, Li, Jihua, Chen, Hongyan, Yu, Chong-Jen, Jin, Li, Chen, Tzu-Yu, Jiang, Shih-Sheng, Liu, Jie, Yamaji, Taiki, Hicks, Belynda, Wyatt, Kathleen, Li, Shengchao A., Dai, Juncheng, Ma, Hongxia, Jin, Guangfu, Song, Bao, Wang, Zhehai, Cheng, Sensen, Li, Xuelian, Ren, Yangwu, Cui, Ping, Iwasaki, Motoki, Shimazu, Taichi, Tsugane, Shoichiro, Zhu, Junjie, Yang, Kaiyun, Jiang, Gening, Fei, Ke, Wu, Guoping, Lin, Hsien-Chin, Chen, Hui-Ling, Fang, Yao-Huei, Tsai, Fang-Yu, Hsieh, Wan-Shan, Yu, Jinming, Stevens, Victoria L., Laird-Offringa, Ite A., Marconett, Crystal N., Rieswijk, Linda, Chao, Ann, Yang, Pan-Chyr, Shu, Xiao-Ou, Wu, Tangchun, Wu, Y.L., Lin, Dongxin, Chen, Kexin, Zhou, Baosen, Huang, Yun-Chao, Kohno, Takashi, Shen, Hongbing, Chanock, Stephen J., Rothman, Nathaniel, and Lan, Qing

Published
2020
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13. Author Correction: A highly sensitive and specific real-time quantitative PCR for BRAF V600E/K mutation screening

Author

Lung, Jrhau, Hung, Ming‑Szu, Lin, Yu‑Ching, Jiang, Yuan Yuan, Fang, Yu‑Hung, Lu, Ming‑Shian, Hsieh, Ching‑Chuan, Wang, Chia‑Siu, Kuan, Feng‑Che, Lu, Chang‑Hsien, Chen, Ping‑Tsung, Lin, Chieh‑Mo, Chou, Yen‑Li, Lin, Chin‑Kuo, Yang, Tsung‑Ming, Chen, Fen Fen, Lin, Paul Yann, Hsieh, Meng‑Jer, and Tsai, Ying Huang

Published
2021
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14. Associations between severe influenza-complicated thromboembolism events, intensive care unit stays and mortality, and associated risk factors: a retrospective cohort study

Author

LEE, WEI CHUN, primary, Chang, Che-Chia, additional, Ho, Meng-Chin, additional, LIN, Chin-Kuo, additional, Lin, Chieh-Mo, additional, Fang, Yu-Hung, additional, Huang, Shu-Yi, additional, Lin, Yu-Ching, additional, Chuang, Min-Chun, additional, Yang, Tsung-Ming, additional, Hung, Ming-Szu, additional, Chou, Yen-Li, additional, Tsai, Ying-Huang, additional, and Hsieh, Meng-Jer, additional

Published
2023
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15. Polygenic Risk Score, Environmental Tobacco Smoke, and Risk of Lung Adenocarcinoma in Never-Smoking Women in Taiwan

Author

Blechter, Batel, primary, Chien, Li-Hsin, additional, Chen, Tzu-Yu, additional, Chang, I-Shou, additional, Choudhury, Parichoy Pal, additional, Hsiao, Chin-Fu, additional, Shu, Xiao-Ou, additional, Wong, Jason Y. Y., additional, Chen, Kuan-Yu, additional, Chang, Gee-Chen, additional, Tsai, Ying-Huang, additional, Su, Wu-Chou, additional, Huang, Ming-Shyan, additional, Chen, Yuh-Min, additional, Chen, Chih-Yi, additional, Hung, Hsiao-Han, additional, Hu, Jia-Wei, additional, Shi, Jianxin, additional, Zheng, Wei, additional, Rositch, Anne F., additional, Chen, Chien-Jen, additional, Chatterjee, Nilanjan, additional, Yang, Pan-Chyr, additional, Rothman, Nathaniel, additional, Hsiung, Chao Agnes, additional, and Lan, Qing, additional

Published
2023
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16. Low-dose CT screening among never-smokers with or without a family history of lung cancer in Taiwan: a prospective cohort study

Author

Chang, Gee-Chen, primary, Chiu, Chao-Hua, additional, Yu, Chong-Jen, additional, Chang, Yeun-Chung, additional, Chang, Ya-Hsuan, additional, Hsu, Kuo-Hsuan, additional, Wu, Yu-Chung, additional, Chen, Chih-Yi, additional, Hsu, Hsian-He, additional, Wu, Ming-Ting, additional, Yang, Cheng-Ta, additional, Chong, Inn-Wen, additional, Lin, Yu-Ching, additional, Hsia, Te-Chun, additional, Lin, Meng-Chih, additional, Su, Wu-Chou, additional, Lin, Chih-Bin, additional, Lee, Kang-Yun, additional, Wei, Yu-Feng, additional, Lan, Gong-Yau, additional, Chan, Wing P, additional, Wang, Kao-Lun, additional, Wu, Mei-Han, additional, Tsai, Hao-Hung, additional, Chian, Chih-Feng, additional, Lai, Ruay-Sheng, additional, Shih, Jin-Yuan, additional, Wang, Chi-Liang, additional, Hsu, Jui-Sheng, additional, Chen, Kun-Chieh, additional, Chen, Chun-Ku, additional, Hsia, Jiun-Yi, additional, Peng, Chung-Kan, additional, Tang, En-Kuei, additional, Hsu, Chia-Lin, additional, Chou, Teh-Ying, additional, Shen, Wei-Chih, additional, Tsai, Ying-Huang, additional, Tsai, Chun-Ming, additional, Chen, Yuh-Min, additional, Lee, Yu-Chin, additional, Chen, Hsuan-Yu, additional, Yu, Sung-Liang, additional, Chen, Chien-Jen, additional, Wan, Yung-Liang, additional, Hsiung, Chao Agnes, additional, Yang, Pan-Chyr, additional, Chan, Chang-Chuan, additional, Chan, Si-Wa, additional, Chang, I-Shou, additional, Chang, Jer-Hwa, additional, Chao, Kun-San, additional, Chen, Chi-Jen, additional, Chen, Huei-Wen, additional, Chiang, Chun-Ju, additional, Chiou, Hung-Yi, additional, Chou, Mei-Chun, additional, Chung, Chi-Li, additional, Chung, Ta-Jung, additional, Guo, Yue Leon, additional, Hsiao, Chin-Fu, additional, Huang, Chien-Sheng, additional, Ko, Sheung-Fat, additional, Lee, Mei-Hsuan, additional, Li, Yao-Jen, additional, Liao, Yu-San, additional, Lu, Yueh-Hsun, additional, Ou, Hsin-You, additional, Wu, Ping-An, additional, Yang, Hwai-I, additional, Yang, Shi-Yi, additional, and Yang, Szu-Chun, additional

Published
2023
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23. Predictive factors for EGFR-tyrosine kinase inhibitor retreatment in patients with EGFR-mutated non-small-cell lung cancer – A multicenter retrospective SEQUENCE study

Author

Chang, Gee-Chen, Tseng, Chien-Hua, Hsu, Kuo-Hsuan, Yu, Chong-Jen, Yang, Cheng-Ta, Chen, Kun-Chieh, Yang, Tsung-Ying, Tseng, Jeng-Sen, Liu, Chien-Ying, Liao, Wei-Yu, Hsia, Te-Chun, Tu, Chih-Yen, Lin, Meng-Chih, Tsai, Ying-Huang, Hsieh, Meng-Jer, Wu, Wen-Shuo, and Chen, Yuh-Min

Published
2017
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28. Low-dose CT screening in relatives with a family history of lung cancer

Author

Wang, Chi-Liang, primary, Hsu, Kuo-Hsuan, additional, Chang, Ya-Hsuan, additional, Ho, Chao-Chi, additional, Chiang, Chun-Ju, additional, Chen, Kun-Chieh, additional, Cheung, Yun-Chung, additional, Huang, Pei-Ching, additional, Chen, Yu-Ruei, additional, Chen, Chih-Yi, additional, Hsu, Chung-Ping, additional, Hsia, Jiun-Yi, additional, Chen, Hsuan-Yu, additional, Yang, Shi-Yi, additional, Li, Yao-Jen, additional, Yang, Tsung-Ying, additional, Tseng, Jeng-Sen, additional, Chuang, Cheng-Yen, additional, Hsiung, Chao A., additional, Chen, Yuh-Min, additional, Huang, Ming-Shyan, additional, Yu, Chong-Jen, additional, Chen, Kuan-Yu, additional, Su, Wu-Chou, additional, Chen, Jeremy J.W., additional, Yu, Sung-Liang, additional, Chen, Chien-Jen, additional, Yang, Pan-Chyr, additional, Tsai, Ying-Huang, additional, and Chang, Gee-Chen, additional

Published
2023
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29. Supplementary Data from Recalibrating Risk Prediction Models by Synthesizing Data Sources: Adapting the Lung Cancer PLCO Model for Taiwan

Author

Chien, Li-Hsin, primary, Chen, Tzu-Yu, primary, Chen, Chung-Hsing, primary, Chen, Kuan-Yu, primary, Hsiao, Chin-Fu, primary, Chang, Gee-Chen, primary, Tsai, Ying-Huang, primary, Su, Wu-Chou, primary, Huang, Ming-Shyan, primary, Chen, Yuh-Min, primary, Chen, Chih-Yi, primary, Liang, Sheng-Kai, primary, Chen, Chung-Yu, primary, Wang, Chih-Liang, primary, Hung, Hsiao-Han, primary, Jiang, Hsin-Fang, primary, Hu, Jia-Wei, primary, Rothman, Nathaniel, primary, Lan, Qing, primary, Liu, Tsang-Wu, primary, Chen, Chien-Jen, primary, Yang, Pan-Chyr, primary, Chang, I-Shou, primary, and Hsiung, Chao A., primary

Published
2023
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30. Supplementary Figure from Recalibrating Risk Prediction Models by Synthesizing Data Sources: Adapting the Lung Cancer PLCO Model for Taiwan

Author

Chien, Li-Hsin, primary, Chen, Tzu-Yu, primary, Chen, Chung-Hsing, primary, Chen, Kuan-Yu, primary, Hsiao, Chin-Fu, primary, Chang, Gee-Chen, primary, Tsai, Ying-Huang, primary, Su, Wu-Chou, primary, Huang, Ming-Shyan, primary, Chen, Yuh-Min, primary, Chen, Chih-Yi, primary, Liang, Sheng-Kai, primary, Chen, Chung-Yu, primary, Wang, Chih-Liang, primary, Hung, Hsiao-Han, primary, Jiang, Hsin-Fang, primary, Hu, Jia-Wei, primary, Rothman, Nathaniel, primary, Lan, Qing, primary, Liu, Tsang-Wu, primary, Chen, Chien-Jen, primary, Yang, Pan-Chyr, primary, Chang, I-Shou, primary, and Hsiung, Chao A., primary

Published
2023
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31. Data from Recalibrating Risk Prediction Models by Synthesizing Data Sources: Adapting the Lung Cancer PLCO Model for Taiwan

Author

Chien, Li-Hsin, primary, Chen, Tzu-Yu, primary, Chen, Chung-Hsing, primary, Chen, Kuan-Yu, primary, Hsiao, Chin-Fu, primary, Chang, Gee-Chen, primary, Tsai, Ying-Huang, primary, Su, Wu-Chou, primary, Huang, Ming-Shyan, primary, Chen, Yuh-Min, primary, Chen, Chih-Yi, primary, Liang, Sheng-Kai, primary, Chen, Chung-Yu, primary, Wang, Chih-Liang, primary, Hung, Hsiao-Han, primary, Jiang, Hsin-Fang, primary, Hu, Jia-Wei, primary, Rothman, Nathaniel, primary, Lan, Qing, primary, Liu, Tsang-Wu, primary, Chen, Chien-Jen, primary, Yang, Pan-Chyr, primary, Chang, I-Shou, primary, and Hsiung, Chao A., primary

Published
2023
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32. Polygenic Risk Score and Lung Adenocarcinoma Risk Among Never-Smokers by EGFR Mutation Status: A Brief Report

Author

Blechter, Batel, Hsiung, Chao Agnes, Wang, Xiaoyu, Zhang, Haoyu, Seow, Wei Jie, Shi, Jianxin, Chatterjee, Nilanjan, Kim, Hee Nam, Wong, Maria Pik, Hong, Yun-Chul, Wong, Jason Y.Y., Dai, Juncheng, Hosgood, H. Dean, Wang, Zhaoming, Chang, I-Shou, Choi, Jiyeon, Wang, Jiucun, Song, Minsun, Hu, Wei, Zheng, Wei, Kim, Jin Hee, Zhou, Baosen, Albanes, Demetrius, Shin, Min-Ho, Chung, Lap Ping, An, She-Juan, Zheng, Hong, Yatabe, Yasushi, Zhang, Xu-Chao, Kim, Young Tae, Shu, Xiao-Ou, Kim, Young-Chul, Vermeulen, Roel C.H., Bassig, Bryan A, Chang, Jiang, Man Ho, James Chung, Ji, Bu-Tian, Kubo, Michiaki, Daigo, Yataro, Momozawa, Yukihide, Kamatani, Yoichiro, Honda, Takayuki, Kunitoh, Hideo, Watanabe, Shun-ichi, Miyagi, Yohei, Nakayama, Haruhiko, Matsumoto, Shingo, Tsuboi, Masahiro, Goto, Koichi, Yin, Zhihua, Takahashi, Atsushi, Goto, Akiteru, Minamiya, Yoshihiro, Shimizu, Kimihiro, Tanaka, Kazumi, Wu, Tangchun, Wei, Fusheng, Su, Jian, Kim, Yeul Hong, Oh, In-Jae, Fun Lee, Victor Ho, Su, Wu-Chou, Chen, Yuh-Min, Chang, Gee-Chen, Chen, Kuan-Yu, Huang, Ming-Shyan, Lin, Hsien-Chih, Seow, Adeline, Park, Jae Yong, Kweon, Sun-Seog, Chen, Chien-Jen, Gao, Yu-Tang, Wu, Chen, Qian, Biyun, Lu, Daru, Liu, Jianjun, Jeon, Hyo-Sung, Hsiao, Chin-Fu, Sung, Jae Sook, Tsai, Ying-Huang, Jung, Yoo Jin, Guo, Huan, Hu, Zhibin, Chen, Tzu-Yu, Burdett, Laurie, Yeager, Meredith, Hutchinson, Amy, Berndt, Sonja I., Wu, Wei, Wang, Junwen, Choi, Jin Eun, Park, Kyong Hwa, Sung, Sook Whan, Liu, Li, Kang, Chang Hyun, Chen, Chung-Hsing, Xu, Jun, Guan, Peng, Tan, Wen, Wang, Chih-Liang, Loon Sihoe, Alan Dart, Chen, Ying, Choi, Yi Young, Kim, Jun Suk, Yoon, Ho-Il, Cai, Qiuyin, Park, In Kyu, Xu, Ping, He, Qincheng, Chen, Chih-Yi, Wu, Junjie, Lim, Wei-Yen, Chen, Kun-Chieh, Chan, John K.C., Li, Jihua, Chen, Hongyan, Yu, Chong-Jen, Jin, Li, Fraumeni, Joseph F., Jr, Liu, Jie, Landi, Maria Teresa, Yamaji, Taiki, Yang, Yang, Hicks, Belynda, Wyatt, Kathleen, Li, Shengchao A., Ma, Hongxia, Song, Bao, Wang, Zhehai, Cheng, Sensen, Li, Xuelian, Ren, Yangwu, Iwasaki, Motoki, Zhu, Junjie, Jiang, Gening, Fei, Ke, Wu, Guoping, Chien, Li-Hsin, Tsai, Fang-Yu, Yu, Jinming, Stevens, Victoria L., Yang, Pan-Chyr, Lin, Dongxin, Chen, Kexin, Wu, Yi-Long, Matsuo, Keitaro, Rothman, Nathaniel, Shiraishi, Kouya, Shen, Hongbing, Chanock, Stephen J., Kohno, Takashi, and Lan, Qing

Published
2024
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36. Afatinib beyond progression in patients with non-small-cell lung cancer following chemotherapy, erlotinib/gefitinib and afatinib: phase III randomized LUX-Lung 5 trial

Author

Ignatius Ou, SaiHong, Planchard, David, Park, Keunchil, Schuler, Martin, Yang, James, Chand, Vikram, Rohr, Klaus, Bagnes, Claudia, Martin, Claudio Marcelo, Recondo, Gonzalo, Zarba, Juan Jose, Blajman, Cesar, Richardet, Martín, McLachlan, Sue-Anne, Parente, Phillip, Underhill, Craig, Crombie, Catherine, Mainwaring, Paul, Greil, Richard, Humblet, Yves, Bustin, Frédérique, Carestia, Luciano, Galdermans, Danny, Lambrechts, Marc, Delval, Laetitia, Vercauter, Piet, Zhou, Caicun, Wang, Jin, Huang, Cheng, Lin, Xiaoyan, Wu, Yilong, Liu, Xiaoqing, Cheng, Ying, Qin, Shukui, Feng, Jifeng, Huang, Jianjin, Zhang, Yiping, Lu, Shun, Zereu, Manuela, Garicochea, Bernardo, Zadra, Cyntia Albuquerque, Riska, Henrik, Alanko, Tuomo, Cadranel, Jacques, Chouaid, Christos, Zalcman, Gérard, Sibilot, Denis Moro, Perol, Maurice, Bennouna, Jaafar, Fournel, Pierre, Gervais, Radj, Rotarski, Maciej, Coudert, Bruno, Thomas, Michael, Wehler, Thomas, Faehling, Martin, Keilholz, Ulrich, Laack, Eckart, von Pawel, Joachim, Huber, Rudolf, Dickgreber, Nicolas, Wiewrodt, Rainer, Mark, Zsuzsanna, Tehenes, Sandor, Strausz, Janos, Sarosi, Veronika, Prabhash, Kumar, Jain, Minish, Venkatesan, Srinivasan, Sharma, Lalit, Dadhich, Hemant, Nagarkar, Rajnish Vasant, Onn, Amir, Gottfried, Maya, Stemmer, Solomon, Migliorino, Maria Rita, Grossi, Francesco, Bidoli, Paolo, Bearz, Alessandra, Gridelli, Cesare, Milandri, Carlo, Platania, Marco, Ceresoli, Giovanni Luca, Cruciani, Giorgio, Delgado, Francisco Gutierrez, Gonzalez Perez, José Luis, Luna, Gabriela Alvarado, Baca, Othon Padilla, Aerts, J.G.J.V., Stigt, J.A., Dingemans, A.M.C., Herder, G.J.M., Gans, S.J.M., Salas Sánchez, Jorge Fernando, Alvarez Barreda, Renzo Luzgardo, Pantigoso, Wilbert Rodriguez, Palomino, Osbert Luis Mejia, Jaskiewicz, Piotr, Kazarnowicz, Andrzej, Serwatowski, Piotr, Szczesna, Aleksandra, Jassem, Jacek, Lubennikov, Vladimir, Karaseva, Nina, Orlov, Sergey, Ragulin, Yuri, Garrido, Pilar, González Larriba, José Luis, Camps, Carlos, Campelo, Rosario García, Lianes, Pilar, Cobo, Manuel, Felip, Enriqueta, Kim, Dong-Wan, Kim, Sang-We, Kim, Joo-Hang, Han, Ji-Youn, Kim, Young-Chul, Yang, Chih-Hsin, Hsia, Te-Chun, Chen, Yuh-Min, Tsai, Ying-Huang, Chang, Gee-Chen, Tsao, Thomas Chang-Yao, Su, Wu-Chou, Huang, Ming-Shyan, Ho, Ching-Liang, Hsieh, Ruey-Kuen, Vinnyk, Yuriy, Popovych, Oleksandr, Ponomarova, Olga, Bondarenko, Igor, Polishchuk, Iryna, Shah, Riyaz, Mitra, Sanka, Popat, Sanjaykumar, Spicer, James, Toy, Elizabeth, Talbot, Toby, Brown, Emma, Upadhyay, Sunil, Summers, Yvonne, Gurtler, Jayne, Meza, Luis, Thropay, John, Schuler, M., Yang, J.C.-H., Park, K., Kim, J.-H., Bennouna, J., Chen, Y.-M., Chouaid, C., De Marinis, F., Feng, J.-F., Grossi, F., Kim, D.-W., Liu, X., Lu, S., Strausz, J., Vinnyk, Y., Wiewrodt, R., Zhou, C., Wang, B., Chand, V.K., and Planchard, D.

Published
2016
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37. Low-dose CT screening among never-smokers with or without a family history of lung cancer in Taiwan: a prospective cohort study

Author

Chang, Gee-Chen, Chiu, Chao-Hua, Yu, Chong-Jen, Chang, Yeun-Chung, Chang, Ya-Hsuan, Hsu, Kuo-Hsuan, Wu, Yu-Chung, Chen, Chih-Yi, Hsu, Hsian-He, Wu, Ming-Ting, Yang, Cheng-Ta, Chong, Inn-Wen, Lin, Yu-Ching, Hsia, Te-Chun, Lin, Meng-Chih, Su, Wu-Chou, Lin, Chih-Bin, Lee, Kang-Yun, Wei, Yu-Feng, Lan, Gong-Yau, Chan, Wing P, Wang, Kao-Lun, Wu, Mei-Han, Tsai, Hao-Hung, Chian, Chih-Feng, Lai, Ruay-Sheng, Shih, Jin-Yuan, Wang, Chi-Liang, Hsu, Jui-Sheng, Chen, Kun-Chieh, Chen, Chun-Ku, Hsia, Jiun-Yi, Peng, Chung-Kan, Tang, En-Kuei, Hsu, Chia-Lin, Chou, Teh-Ying, Shen, Wei-Chih, Tsai, Ying-Huang, Tsai, Chun-Ming, Chen, Yuh-Min, Lee, Yu-Chin, Chen, Hsuan-Yu, Yu, Sung-Liang, Chen, Chien-Jen, Wan, Yung-Liang, Hsiung, Chao Agnes, Yang, Pan-Chyr, Chan, Chang-Chuan, Chan, Si-Wa, Chang, I-Shou, Chang, Jer-Hwa, Chao, Kun-San, Chen, Chi-Jen, Chen, Huei-Wen, Chiang, Chun-Ju, Chiou, Hung-Yi, Chou, Mei-Chun, Chung, Chi-Li, Chung, Ta-Jung, Guo, Yue Leon, Hsiao, Chin-Fu, Huang, Chien-Sheng, Ko, Sheung-Fat, Lee, Mei-Hsuan, Li, Yao-Jen, Liao, Yu-San, Lu, Yueh-Hsun, Ou, Hsin-You, Wu, Ping-An, Yang, Hwai-I, Yang, Shi-Yi, and Yang, Szu-Chun

Abstract

In Taiwan, lung cancers occur predominantly in never-smokers, of whom nearly 60% have stage IV disease at diagnosis. We aimed to assess the efficacy of low-dose CT (LDCT) screening among never-smokers, who had other risk factors for lung cancer.

Published
2024
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38. Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Author

IRAS OH Epidemiology Chemical Agents, Shi, Jianxin, Shiraishi, Kouya, Choi, Jiyeon, Matsuo, Keitaro, Chen, Tzu-Yu, Dai, Juncheng, Hung, Rayjean J, Chen, Kexin, Shu, Xiao-Ou, Kim, Young Tae, Landi, Maria Teresa, Lin, Dongxin, Zheng, Wei, Yin, Zhihua, Zhou, Baosen, Song, Bao, Wang, Jiucun, Seow, Wei Jie, Song, Lei, Chang, I-Shou, Hu, Wei, Chien, Li-Hsin, Cai, Qiuyin, Hong, Yun-Chul, Kim, Hee Nam, Wu, Yi-Long, Wong, Maria Pik, Richardson, Brian Douglas, Funderburk, Karen M, Li, Shilan, Zhang, Tongwu, Breeze, Charles, Wang, Zhaoming, Blechter, Batel, Bassig, Bryan A, Kim, Jin Hee, Albanes, Demetrius, Wong, Jason Y Y, Shin, Min-Ho, Chung, Lap Ping, Yang, Yang, An, She-Juan, Zheng, Hong, Yatabe, Yasushi, Zhang, Xu-Chao, Kim, Young-Chul, Caporaso, Neil E, Chang, Jiang, Ho, James Chung Man, Kubo, Michiaki, Daigo, Yataro, Song, Minsun, Momozawa, Yukihide, Kamatani, Yoichiro, Kobayashi, Masashi, Okubo, Kenichi, Honda, Takayuki, Hosgood, Dean H, Kunitoh, Hideo, Patel, Harsh, Watanabe, Shun-Ichi, Miyagi, Yohei, Nakayama, Haruhiko, Matsumoto, Shingo, Horinouchi, Hidehito, Tsuboi, Masahiro, Hamamoto, Ryuji, Goto, Koichi, Ohe, Yuichiro, Takahashi, Atsushi, Goto, Akiteru, Minamiya, Yoshihiro, Hara, Megumi, Nishida, Yuichiro, Takeuchi, Kenji, Wakai, Kenji, Matsuda, Koichi, Murakami, Yoshinori, Shimizu, Kimihiro, Suzuki, Hiroyuki, Saito, Motonobu, Ohtaki, Yoichi, Tanaka, Kazumi, Wu, Tangchun, Wei, Fusheng, Dai, Hongji, Machiela, Mitchell J, Su, Jian, Kim, Yeul Hong, Oh, In-Jae, Lee, Victor Ho Fun, Chang, Gee-Chen, Tsai, Ying-Huang, Chen, Kuan-Yu, Huang, Ming-Shyan, Su, Wu-Chou, Chen, Yuh-Min, Seow, Adeline, Park, Jae Yong, Kweon, Sun-Seog, Chen, Kun-Chieh, Gao, Yu-Tang, Qian, Biyun, Wu, Chen, Lu, Daru, Liu, Jianjun, Schwartz, Ann G, Houlston, Richard, Spitz, Margaret R, Gorlov, Ivan P, Wu, Xifeng, Yang, Ping, Lam, Stephen, Tardon, Adonina, Chen, Chu, Bojesen, Stig E, Johansson, Mattias, Risch, Angela, Bickeböller, Heike, Ji, Bu-Tian, Wichmann, H-Erich, Christiani, David C, Rennert, Gadi, Arnold, Susanne, Brennan, Paul, McKay, James, Field, John K, Shete, Sanjay S, Le Marchand, Loic, Liu, Geoffrey, Andrew, Angeline, Kiemeney, Lambertus A, Zienolddiny-Narui, Shan, Grankvist, Kjell, Johansson, Mikael, Cox, Angela, Taylor, Fiona, Yuan, Jian-Min, Lazarus, Philip, Schabath, Matthew B, Aldrich, Melinda C, Jeon, Hyo-Sung, Jiang, Shih Sheng, Sung, Jae Sook, Chen, Chung-Hsing, Hsiao, Chin-Fu, Jung, Yoo Jin, Guo, Huan, Hu, Zhibin, Burdett, Laurie, Yeager, Meredith, Hutchinson, Amy, Hicks, Belynda, Liu, Jia, Zhu, Bin, Berndt, Sonja I, Wu, Wei, Wang, Junwen, Li, Yuqing, Choi, Jin Eun, Park, Kyong Hwa, Sung, Sook Whan, Liu, Li, Kang, Chang Hyun, Wang, Wen-Chang, Xu, Jun, Guan, Peng, Tan, Wen, Yu, Chong-Jen, Yang, Gong, Sihoe, Alan Dart Loon, Chen, Ying, Choi, Yi Young, Kim, Jun Suk, Yoon, Ho-Il, Park, In Kyu, Xu, Ping, He, Qincheng, Wang, Chih-Liang, Hung, Hsiao-Han, Vermeulen, Roel C H, Cheng, Iona, Wu, Junjie, Lim, Wei-Yen, Tsai, Fang-Yu, Chan, John K C, Li, Jihua, Chen, Hongyan, Lin, Hsien-Chih, Jin, Li, Liu, Jie, Sawada, Norie, Yamaji, Taiki, Wyatt, Kathleen, Li, Shengchao A, Ma, Hongxia, Zhu, Meng, Wang, Zhehai, Cheng, Sensen, Li, Xuelian, Ren, Yangwu, Chao, Ann, Iwasaki, Motoki, Zhu, Junjie, Jiang, Gening, Fei, Ke, Wu, Guoping, Chen, Chih-Yi, Chen, Chien-Jen, Yang, Pan-Chyr, Yu, Jinming, Stevens, Victoria L, Fraumeni, Joseph F, Chatterjee, Nilanjan, Gorlova, Olga Y, Hsiung, Chao Agnes, Amos, Christopher I, Shen, Hongbing, Chanock, Stephen J, Rothman, Nathaniel, Kohno, Takashi, Lan, Qing, IRAS OH Epidemiology Chemical Agents, Shi, Jianxin, Shiraishi, Kouya, Choi, Jiyeon, Matsuo, Keitaro, Chen, Tzu-Yu, Dai, Juncheng, Hung, Rayjean J, Chen, Kexin, Shu, Xiao-Ou, Kim, Young Tae, Landi, Maria Teresa, Lin, Dongxin, Zheng, Wei, Yin, Zhihua, Zhou, Baosen, Song, Bao, Wang, Jiucun, Seow, Wei Jie, Song, Lei, Chang, I-Shou, Hu, Wei, Chien, Li-Hsin, Cai, Qiuyin, Hong, Yun-Chul, Kim, Hee Nam, Wu, Yi-Long, Wong, Maria Pik, Richardson, Brian Douglas, Funderburk, Karen M, Li, Shilan, Zhang, Tongwu, Breeze, Charles, Wang, Zhaoming, Blechter, Batel, Bassig, Bryan A, Kim, Jin Hee, Albanes, Demetrius, Wong, Jason Y Y, Shin, Min-Ho, Chung, Lap Ping, Yang, Yang, An, She-Juan, Zheng, Hong, Yatabe, Yasushi, Zhang, Xu-Chao, Kim, Young-Chul, Caporaso, Neil E, Chang, Jiang, Ho, James Chung Man, Kubo, Michiaki, Daigo, Yataro, Song, Minsun, Momozawa, Yukihide, Kamatani, Yoichiro, Kobayashi, Masashi, Okubo, Kenichi, Honda, Takayuki, Hosgood, Dean H, Kunitoh, Hideo, Patel, Harsh, Watanabe, Shun-Ichi, Miyagi, Yohei, Nakayama, Haruhiko, Matsumoto, Shingo, Horinouchi, Hidehito, Tsuboi, Masahiro, Hamamoto, Ryuji, Goto, Koichi, Ohe, Yuichiro, Takahashi, Atsushi, Goto, Akiteru, Minamiya, Yoshihiro, Hara, Megumi, Nishida, Yuichiro, Takeuchi, Kenji, Wakai, Kenji, Matsuda, Koichi, Murakami, Yoshinori, Shimizu, Kimihiro, Suzuki, Hiroyuki, Saito, Motonobu, Ohtaki, Yoichi, Tanaka, Kazumi, Wu, Tangchun, Wei, Fusheng, Dai, Hongji, Machiela, Mitchell J, Su, Jian, Kim, Yeul Hong, Oh, In-Jae, Lee, Victor Ho Fun, Chang, Gee-Chen, Tsai, Ying-Huang, Chen, Kuan-Yu, Huang, Ming-Shyan, Su, Wu-Chou, Chen, Yuh-Min, Seow, Adeline, Park, Jae Yong, Kweon, Sun-Seog, Chen, Kun-Chieh, Gao, Yu-Tang, Qian, Biyun, Wu, Chen, Lu, Daru, Liu, Jianjun, Schwartz, Ann G, Houlston, Richard, Spitz, Margaret R, Gorlov, Ivan P, Wu, Xifeng, Yang, Ping, Lam, Stephen, Tardon, Adonina, Chen, Chu, Bojesen, Stig E, Johansson, Mattias, Risch, Angela, Bickeböller, Heike, Ji, Bu-Tian, Wichmann, H-Erich, Christiani, David C, Rennert, Gadi, Arnold, Susanne, Brennan, Paul, McKay, James, Field, John K, Shete, Sanjay S, Le Marchand, Loic, Liu, Geoffrey, Andrew, Angeline, Kiemeney, Lambertus A, Zienolddiny-Narui, Shan, Grankvist, Kjell, Johansson, Mikael, Cox, Angela, Taylor, Fiona, Yuan, Jian-Min, Lazarus, Philip, Schabath, Matthew B, Aldrich, Melinda C, Jeon, Hyo-Sung, Jiang, Shih Sheng, Sung, Jae Sook, Chen, Chung-Hsing, Hsiao, Chin-Fu, Jung, Yoo Jin, Guo, Huan, Hu, Zhibin, Burdett, Laurie, Yeager, Meredith, Hutchinson, Amy, Hicks, Belynda, Liu, Jia, Zhu, Bin, Berndt, Sonja I, Wu, Wei, Wang, Junwen, Li, Yuqing, Choi, Jin Eun, Park, Kyong Hwa, Sung, Sook Whan, Liu, Li, Kang, Chang Hyun, Wang, Wen-Chang, Xu, Jun, Guan, Peng, Tan, Wen, Yu, Chong-Jen, Yang, Gong, Sihoe, Alan Dart Loon, Chen, Ying, Choi, Yi Young, Kim, Jun Suk, Yoon, Ho-Il, Park, In Kyu, Xu, Ping, He, Qincheng, Wang, Chih-Liang, Hung, Hsiao-Han, Vermeulen, Roel C H, Cheng, Iona, Wu, Junjie, Lim, Wei-Yen, Tsai, Fang-Yu, Chan, John K C, Li, Jihua, Chen, Hongyan, Lin, Hsien-Chih, Jin, Li, Liu, Jie, Sawada, Norie, Yamaji, Taiki, Wyatt, Kathleen, Li, Shengchao A, Ma, Hongxia, Zhu, Meng, Wang, Zhehai, Cheng, Sensen, Li, Xuelian, Ren, Yangwu, Chao, Ann, Iwasaki, Motoki, Zhu, Junjie, Jiang, Gening, Fei, Ke, Wu, Guoping, Chen, Chih-Yi, Chen, Chien-Jen, Yang, Pan-Chyr, Yu, Jinming, Stevens, Victoria L, Fraumeni, Joseph F, Chatterjee, Nilanjan, Gorlova, Olga Y, Hsiung, Chao Agnes, Amos, Christopher I, Shen, Hongbing, Chanock, Stephen J, Rothman, Nathaniel, Kohno, Takashi, and Lan, Qing

Published
2023

39. Supplementary Data from EGFR L858R Mutation and Polymorphisms of Genes Related to Estrogen Biosynthesis and Metabolism in Never-Smoking Female Lung Adenocarcinoma Patients

Author

Yang, Shi-Yi, primary, Yang, Tsung-Ying, primary, Chen, Kun-Chieh, primary, Li, Yao-Jen, primary, Hsu, Kuo-Hsuan, primary, Tsai, Chi-Rne, primary, Chen, Chih-Yi, primary, Hsu, Chung-Ping, primary, Hsia, Jiun-Yi, primary, Chuang, Cheng-Yen, primary, Tsai, Ying-Huang, primary, Chen, Kuan-Yu, primary, Huang, Ming-Shyan, primary, Su, Wu-Chou, primary, Chen, Yuh-Min, primary, Hsiung, Chao A., primary, Shen, Chen-Yang, primary, Chang, Gee-Chen, primary, Yang, Pan-Chyr, primary, and Chen, Chien-Jen, primary

Published
2023
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45. Serum vascular endothelial growth factor independently affects tissue fluid accumulation and is related to deteriorating tissue perfusion and oxygenation in severe sepsis: a prospective observational study

Author

Lin, Chin-Kuo, primary, Tsai, Ying-Huang, additional, Kao, Kuo-Chin, additional, Lin, Chieh-Mo, additional, Zhou, Shao-Kui, additional, Ho, Meng-Chin, additional, Huang, Shu-Yi, additional, Fang, Yu-Hung, additional, Chang, Che-Chia, additional, Lee, Wei-Chun, additional, Lee, Yueh-Lin, additional, Chen, Min-Chi, additional, Hsieh, Meng-Jer, additional, Lin, Yu-Ching, additional, Hung, Ming-Szu, additional, Kuo, Wen-Chun, additional, and Lin, Bor-Shyh, additional

Published
2022
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46. Increased tissue water in patients with severe sepsis affects tissue oxygenation measured by near-infrared spectroscopy: a prospective, observational case-control study

Author

Lin, Chin-Kuo, primary, Leu, Shaw-Woei, additional, Tsai, Ying-Huang, additional, Zhou, Shao-Kui, additional, Lin, Chieh-Mo, additional, Huang, Shu-Yi, additional, Chang, Che-Chia, additional, Ho, Meng-Chin, additional, Lee, Wei-Chun, additional, Chen, Min-Chi, additional, Hung, Ming-Szu, additional, Lin, Yu-Ching, additional, Li, Jhe-Ruei, additional, and Lin, Bor-Shyh, additional

Published
2022
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47. Recalibrating Risk Prediction Models by Synthesizing Data Sources: Adapting the Lung Cancer PLCO Model for Taiwan

Author

Chien, Li-Hsin, primary, Chen, Tzu-Yu, additional, Chen, Chung-Hsing, additional, Chen, Kuan-Yu, additional, Hsiao, Chin-Fu, additional, Chang, Gee-Chen, additional, Tsai, Ying-Huang, additional, Su, Wu-Chou, additional, Huang, Ming-Shyan, additional, Chen, Yuh-Min, additional, Chen, Chih-Yi, additional, Liang, Sheng-Kai, additional, Chen, Chung-Yu, additional, Wang, Chih-Liang, additional, Hung, Hsiao-Han, additional, Jiang, Hsin-Fang, additional, Hu, Jia-Wei, additional, Rothman, Nathaniel, additional, Lan, Qing, additional, Liu, Tsang-Wu, additional, Chen, Chien-Jen, additional, Yang, Pan-Chyr, additional, Chang, I-Shou, additional, and Hsiung, Chao A., additional

Published
2022
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50. The potential and limitation of targeted chromosomal breakpoint sequencing for the ROS1 fusion gene identification in lung cancer

Author

Hung, Ming-Szu, Lin, Yu-Ching, Chen, Fen-Fen, Jiang, Yuan-Yuan, Fang, Yu-Hung, Lu, Ming-Shian, Lin, Chin-Kuo, Yang, Tsung-Ming, Lung, Jrhau, Chen, Chih-Cheng, Lee, Kuan-Der, and Tsai, Ying-Huang

Subjects
Original Article
Abstract

ROS1 fusion genes are rare but important driver genes in lung cancer. Owing to their rarity, many clinicopathological features and treatment responses for each ROS1 fusion variant are still largely unknown and require further investigation. RNA is the preferable template for the ROS1 fusion gene screening, but deterioration of RNA in FFPE often makes the detection challenging. To resolve the difficulty, a targeted chromosomal breakpoint sequencing method was developed for searching the ROS1 fusion gene, and was compared with fluorescence in situ hybridization, immunohistochemistry, RT-qPCR using 260 lung cancer samples of Southern Taiwan. The results showed that ROS1-altered cases were present at low frequencies, did not share distinct clinicopathological features, and often carried other driver mutations. The performance of the targeted sequencing assay was superior to the RT-qPCR in ROS1 fusion gene identification when the cDNAs were from FFPE samples, but long-read DNA sequencing and fresh-frozen samples would be better to revolve all fusion genes. Precise determination of all ROS1 fusion variants and concomitant driver mutations using both genomic DNA and RNA would be required to help improve the treatment of patients with ROS1 alterations.

Published
2022

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