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10. DNA methylation age in paired tumor and adjacent normal breast tissue in Chinese women with breast cancer

Author

Koka, Hela, Bodelon, Clara, Horvath, Steve, Lee, Priscilla Ming Yi, Wang, Difei, Song, Lei, Zhang, Tongwu, Hurson, Amber N., Guida, Jennifer Lyn, Zhu, Bin, Bailey-Whyte, Maeve, Wang, Feng, Wu, Cherry, Tsang, Koon Ho, Tsoi, Yee-Kei, Chan, W. C., Law, Sze Hong, Hung, Ray Ka Wai, Tse, Gary M., Yuen, Karen Ka-wan, Karlins, Eric, Jones, Kristine, Vogt, Aurelie, Zhu, Bin, Hutchinson, Amy, Hicks, Belynda, Garcia-Closas, Montserrat, Chanock, Stephen, Barnholtz-Sloan, Jill, Tse, Lap Ah, and Yang, Xiaohong R.

Published
2023
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21. Household Air Pollution and Adult Lung Function Change, Respiratory Disease, and Mortality across Eleven Low- and Middle-Income Countries from the PURE Study

Author

Wang, Ying, Duong, MyLinh, Brauer, Michael, Rangarajan, Sumathy, Dans, Antonio, Lanas, Fernando, Lopez-Jaramillo, Patricio, Puoane, Thandi, Yeates, Karen, Chifamba, Jephat, Yusuf, Rita, Liu, Zhiguang, Li, Yang, Tse, Lap Ah, Mohan, Deepa, Gupta, Rajeev, Nair, Sanjeev, Lakshmi, P.V.M., Iqbal, Romaina, Anto, Taniya, Yusuf, Salim, and Hystad, Perry

Subjects
Respiratory tract diseases -- Environmental aspects -- Risk factors -- Patient outcomes, Developing countries -- Environmental aspects -- Health aspects, Environmental issues, Health
Abstract

Background: Globally, household air pollution (HAP) is a major environmental hazard that affects respiratory health. However, few studies have examined associations between HAP and lung function decline and respiratory disease and mortality. Methods: We used data from the Prospective Urban and Rural Epidemiology study and examined adults residing in 240 rural communities in 11 low- and middle-income countries where HAP from cooking with solid fuels is common. Spirometry was conducted for 28,574 individuals at baseline and 12,489 individuals during follow-up (mean of 8 y between spirometry measures). In cross-sectional analyses, we compared lung function measurements [forced expiratory volume in 1 s (FE[V.sub.1]), forced vital capacity (FVC), and FE[V.sub.1]/FVC ratio] in those who used solid fuels for cooking in comparison with clean fuels. Using repeated measurements of lung function, we examined the percent change in lung function measures per year, comparing individuals by baseline fuel type and individuals who used solid fuels at baseline but switched to clean fuels during follow-up. We also examined associations with prospective health events (any respiratory diseases, respiratory disease hospitalizations, and all-cause mortality). Results: In adjusted cross-sectional models, use of solid fuel in comparison with clean fuels was associated with lower FE[V.sub.1] of -17.5 mL (95% CI: -32.7, -2.3) and FVC of -14.4 mL (95% CI: -32.0, 3.2), but not FE[V.sub.1]/FVC. In longitudinal analyses, individuals who switched from solid fuels to clean cooking fuels during follow-up (n = 3,901, 46% of those using solid fuel at baseline), showed no differences in the annual rate of change in FE[V.sub.1] or FVC, but had small improvements in FE[V.sub.1]/FVC change (0.2% per year, 95% CI: 0.03, 0.3). Individuals who switched from solid to clean fuels had a decreased hazard ratio for respiratory events of 0.76 (95% CI: 0.57, 1.00) in comparison with persistent solid fuel users, which was not attenuated by lung function measures. Conclusion: We observed modest associations between HAP exposure and lung function, lung function change, and respiratory disease and mortality. https://doi.org/10.1289/EHP11179, Introduction Approximately 3 billion people worldwide are exposed to household air pollution (HAP) from cooking or heating with solid fuels, such as wood, coal, dung, and crop residues, with most [...]

Published
2023
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25. Household and personal air pollution exposure measurements from 120 communities in eight countries: results from the PURE-AIR study

Author

Shupler, Matthew, Hystad, Perry, Birch, Aaron, Miller-Lionberg, Daniel, Jeronimo, Matthew, Arku, Raphael E, Chu, Yen Li, Mushtaha, Maha, Heenan, Laura, Rangarajan, Sumathy, Seron, Pamela, Lanas, Fernando, Cazor, Fairuz, Lopez-Jaramillo, Patricio, Camacho, Paul A, Perez, Maritza, Yeates, Karen, West, Nicola, Ncube, Tatenda, Ncube, Brian, Chifamba, Jephat, Yusuf, Rita, Khan, Afreen, Hu, Bo, Liu, Xiaoyun, Wei, Li, Tse, Lap Ah, Mohan, Deepa, Kumar, Parthiban, Gupta, Rajeev, Mohan, Indu, Jayachitra, K G, Mony, Prem K, Rammohan, Kamala, Nair, Sanjeev, Lakshmi, P V M, Sagar, Vivek, Khawaja, Rehman, Iqbal, Romaina, Kazmi, Khawar, Yusuf, Salim, and Brauer, Michael

Published
2020
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26. Association of smoking cessation with airflow obstruction in workers with silicosis: A cohort study.

Author

Yang, Shuyuan, Chan, Chi Kuen, Wang, Maggie Haitian, Leung, Chi Chiu, Tai, Lai Bun, and Tse, Lap Ah

Subjects
SMOKING cessation, CIGARETTE smoke, SILICOSIS, SMOKING, FORCED expiratory volume, CHRONIC obstructive pulmonary disease, COHORT analysis
Abstract

Background: Studies in general population reported a positive association between tobacco smoking and airflow obstruction (AFO), a hallmark of chronic obstructive pulmonary disease (COPD). However, this attempt was less addressed in silica dust-exposed workers. Methods: This retrospective cohort study consisted of 4481 silicotic workers attending the Pneumoconiosis Clinic during 1981–2019. The lifelong work history and smoking habits of these workers were extracted from medical records. Spirometry was carried out at the diagnosis of silicosis (n = 4177) and reperformed after an average of 9.4 years of follow-up (n = 2648). AFO was defined as forced expiratory volume in one second (FEV1)/force vital capacity (FVC) less than lower limit of normal (LLN). The association of AFO with smoking status was determined using multivariate logistics regression, and the effect of smoking cessation on the development of AFO was evaluated Cox regression. Results: Smoking was significantly associated with AFO (current smokers: OR = 1.92, 95% CI 1.51–2.44; former smokers: OR = 2.09, 95% CI 1.65–2.66). The risk of AFO significantly increased in the first 3 years of quitting smoking (OR = 1.23, 95% CI 1.02–1.47) but decreased afterwards with increasing years of cessation. Smoking cessation reduced the risk of developing AFO no matter before or after the confirmation of silicosis (pre-silicosis cessation: HR = 0.58, 95% CI 0.46–0.74; post-silicosis cessation: HR = 0.62, 95% CI 0.48–0.79). Conclusions: Smoking cessation significantly reduced the risk of AFO in the workers with silicosis, although the health benefit was not observed until 3 years of abstinence. These findings highlight the importance of early and long-term smoking cessation among silicotic or silica dust-exposed workers. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Associations of outdoor fine particulate air pollution and cardiovascular disease in 157 436 individuals from 21 high-income, middle-income, and low-income countries (PURE): a prospective cohort study

Author

Hystad, Perry, Larkin, Andrew, Rangarajan, Sumathy, AlHabib, Khalid F, Avezum, Álvaro, Calik, Kevser Burcu Tumerdem, Chifamba, Jephat, Dans, Antonio, Diaz, Rafael, du Plessis, Johan L, Gupta, Rajeev, Iqbal, Romaina, Khatib, Rasha, Kelishadi, Roya, Lanas, Fernando, Liu, Zhiguang, Lopez-Jaramillo, Patricio, Nair, Sanjeev, Poirier, Paul, Rahman, Omar, Rosengren, Annika, Swidan, Hany, Tse, Lap Ah, Wei, Li, Wielgosz, Andreas, Yeates, Karen, Yusoff, Khalid, Zatoński, Tomasz, Burnett, Rick, Yusuf, Salim, and Brauer, Michael

Published
2020
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