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1. Real-world treatment outcome with protease inhibitor direct-acting antiviral in advanced hepatitis C cirrhosis: a REAL-C study

Author

Wong, Yu Jun, Tran, Sally, Huang, Chung-Feng, Hsu, Yao-Chun, Preda, Carmen, Toyoda, Hidenori, Liu, Joanne, Jun, Dae Won, Landis, Charles, Huang, Daniel Q., Gila, Andrei, Negoita, Livia, Yasuda, Satoshi, Tseng, Cheng-Hao, Tsai, Pei-Chien, Uojima, Haruki, Nozaki, Akito, Chuma, Makoto, Atsukawa, Masanori, Ishigami, Masatoshi, Itokawa, Norio, Iio, Etsuko, Lam, Carla Pui-Mei, Watanabe, Tsunamasa, Asai, Akira, Yokohama, Keisuke, Abe, Hiroshi, Enomoto, Masaru, Kawada, Norifumi, Tamori, Akihiro, Lee, Dong Hyun, Jun, Mi Jung, Do, Son, Vo, Dang K. H., Liu, Li, Li, Junyi, Ji, Fanpu, Wang, Wenjun, Li, Yu, Wang, Xiaozhong, Guo, Fen, Xu, Qiang, Jing, Liang, Ye, Qing, Pan, Hongying, Zhang, JiaJie, Wen, Xie, Wang, Qi, Ren, Hong, Cai, Dachuan, Shang, Jia, Liu, Junping, Lu, Chengzheng, Zang, Wenqian, Li, Jia, Niu, Junqi, Zhang, Mingyuan, Wu, Chao, Huang, Rui, Maeda, Mayumi, Nakanishi, Akiko, Yeh, Ming-Lun, Chuang, Wan-Long, Huang, Jee-Fu, Dai, ChiaYen, Ishikawa, Toru, Takaguchi, Koichi, Senoh, Tomonori, Trinh, Huy N., Takahashi, Hirokazu, Eguchi, Yuichiro, Quek, Sabrina Xin Zi, Haga, Hiroaki, Ogawa, Eiichi, Wong, Grace, Buti, Maria, Fukunishi, Shinya, Ueno, Yoshiyuki, Yuen, Man-Fung, Tanaka, Yasuhito, Lim, Seng Gee, Cheung, Ramsey, Yu, Ming-Lung, and Nguyen, Mindie H.

Published
2023
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2. Sex and ethnic disparities in hepatitis B evaluation and treatment across the world

Author

Kudaravalli, Sahith, Huang, Daniel Q., Yeh, Ming-Lun, Trinh, Lindsey, Tsai, P.C., Hsu, Yao-Chun, Kam, Leslie Y., Nguyen, Vy H., Ogawa, Eiichi, Lee, Dong Hyun, Ito, Takanori, Watanabe, Tsunamasa, Enomoto, Masaru, Preda, Carmen Monica, Ko, Michael K.L., Wan-Hin Hui, Rex, Atsukawa, Masanori, Suzuki, Takanori, Marciano, Sebastian, Barreira, Ana, Do, Son, Uojima, Haruki, Takahashi, Hirokazu, Quek, Sabrina X.Z., Toe Wai Khine, Htet Htet, Ishigami, Masatoshi, Itokawa, Norio, Go, Min Seok, Kozuka, Ritsuzo, Marin, Raluca Ioana, Sandra, Irina, Li, Jiayi, Zhang, Jian Q., Wong, Christopher, Yoshimaru, Yoko, Vo, Dang K.H., Tseng, Cheng-Hao, Lee, Chul-jin, Inoue, Kaori, Maeda, Mayumi, Hoang, Joseph K., Chau, Angela, Chuang, Wan-Long, Dai, Chia-Yen, Huang, Jee-Fu, Huang, Chung-Feng, Buti, Maria, Tanaka, Yasuhito, Gadano, Adrian Carlos, Yuen, Man-Fung, Cheung, Ramsey, Lim, Seng Gee, Trinh, Huy N., Toyoda, Hidenori, Yu, Ming-Lung, and Nguyen, Mindie H.

Published
2024
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3. Sex Differences in Treatment Response to Nucleos(t)ide Therapy in Chronic Hepatitis B: A Multicenter Longitudinal Study

Author

Chau, Angela, Yeh, Ming-Lun, Tsai, Pei-Chien, Huang, Daniel Q., Kim, Sung Eun, Trinh, Huy, Yoon, Eileen L., Oh, Hyunwoo, Jeong, Jae Yoon, Ahn, Sang Bong, An, Jihyun, Tseng, Cheng-Hao, Hsu, Yao-Chun, Jeong, Soung Won, Cho, Yong Kyun, Shim, Jae-Jun, Kim, Hyoung Su, Ito, Takanori, Marciano, Sebastián, Kawashima, Keigo, Suzuki, Takanori, Watanabe, Tsunamasa, Nozaki, Akito, Ishikawa, Toru, Inoue, Kaori, Eguchi, Yuichiro, Uojima, Haruki, Abe, Hiroshi, Takahashi, Hirokazu, Chuma, Makoto, Ishigami, Masatoshi, Hoang, Joseph K., Maeda, Mayumi, Huang, Chung-Feng, Gadano, Adrian, Dai, Chia-Yen, Huang, Jee-Fu, Tanaka, Yasuhito, Chuang, Wan-Long, Lim, Seng Gee, Cheung, Ramsey, Yu, Ming-Lung, Jun, Dae-Won, and Nguyen, Mindie H.

Published
2024
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4. Safety, pharmacodynamics, and antiviral activity of selgantolimod in viremic patients with chronic hepatitis B virus infection

Author

Janssen, Harry L., Lim, Young-Suk, Kim, Hyung Joon, Sowah, Leonard, Tseng, Cheng-Hao, Coffin, Carla S., Elkhashab, Magdy, Ahn, Sang Hoon, Nguyen, Anh-Hoa, Chen, Diana, Wallin, Jeffrey J., Fletcher, Simon P., McDonald, Circe, Yang, Jenny C., Gaggar, Anuj, Brainard, Diana M., Fung, Scott, Kim, Yoon Jun, Kao, Jia-Horng, Chuang, Wan-Long, Brooks, Anna E., and Dunbar, P. Rod

Published
2024
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5. Malignant Neoplasms of the Small Intestines

Author

Hu, Ming-Luen, Chiu, Yi-Chun, Tai, Wei-Chen, Huang, Hsuan-Ying, Yen, Hsu-Heng, Chen, Yang-Yuan, Chen, Chung-Wei, Su, Ming-Yao, Lin, Wei-Pin, Chiu, Cheng-Tang, Chou, Jen-Wei, Feng, Chun-Lung, Huang, Shang-Fen, Shih, Yi-Sing, Chen, Shih-Feng, Ting, Chun-Fu, Chiang, I-Ping, Yii, Chin-Yuan, Huang, H. C., Chen, Chien-Tzu, Chang, Chen-Wang, Wang, Horng-Yuan, Chang, Ching-Wei, Tsai, Chia-Chi, Lin, Shee-Chan, Shih, Shou-Chuan, Tai, Chi-Ming, Tu, Chia-Hung, Lee, Tsung-Chun, Perng, Daw-Shyong, Shun, Chia-Tung, Wang, Hsiu-Po, Lin, Ching-Chung, Chang, Wen-Hsiung, Chan, Yu-Jan, Chen, Yu-Jen, Chang, Yi-Fang, Tseng, Cheng-Hao, Chen, Yaw-Sen, Mo, Lein-Ray, Chiu, Cheng-Tang, editor, Wang, Hsiu-Po, editor, and Chen, Yang-Yuan, editor

Published
2023
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6. Second-line levofloxacin-based quadruple therapy versus bismuth-based quadruple therapy for Helicobacter pylori eradication and long-term changes to the gut microbiota and antibiotic resistome: a multicentre, open-label, randomised controlled trial

Author

Wu, Chun-Ying, Lee, Yi-Chia, Tseng, Ping-Huei, Wu, Jeng-Yih, Tai, Chi-Ming, Lee, Ching-Tai, Wang, Wen-Lun, Liou, Jyh-Ming, Jiang, Xiao-Tao, Chen, Chieh-Chang, Luo, Jiing-Chyuan, Bair, Ming-Jong, Chen, Po-Yueh, Chou, Chu-Kuang, Fang, Yu-Jen, Chen, Mei-Jyh, Chen, Chien-Chuan, Lee, Ji-Yuh, Yang, Tsung-Hua, Yu, Chien-Chun, Kuo, Chia-Chi, Chiu, Min-Chin, Chen, Chi-Yi, Shun, Chia-Tung, Hu, Wen-Hao, Tsai, Min-Horn, Hsu, Yao-Chun, Tseng, Cheng-Hao, Chang, Chi-Yang, Lin, Jaw-Town, El-Omar, Emad M, and Wu, Ming-Shiang

Published
2023
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8. Changes in Serum Rheumatoid Factor Following Eradication of Hepatitis C Virus Infection With Interferon or Direct Antiviral Therapy.

Author

Tsai, Ying‐Nan, Lo, Jamie Chieh, Tseng, Cheng‐Hao, Hsieh, Song‐Chou, Chiu, Wen‐Chin, Tai, Chi‐Ming, Chang, Chi‐Yang, Lee, Fu‐Jen, Nguyen, Mindie H., Lin, Jaw‐Town, and Hsu, Yao‐Chun

Subjects
HEPATITIS C, RHEUMATOID factor, HEPATITIS C virus, SEROCONVERSION, AUTOANTIBODIES
Abstract

Hepatitis C virus (HCV) infection is associated with a myriad of extrahepatic manifestations (EHM), as well as the production of autoantibodies, including rheumatoid factor (RF). This study aims to elucidate whether serum levels of RF change before and after HCV eradication, and whether these changes differ according to the type of therapy used. This is a retrospective cohort study of adults with chronic HCV infection treated with interferon‐free or interferon‐based regimens. All patients had HCV viremia at baseline and documented sustained virological response (SVR) 12 or 24 weeks after completing treatment. We measured the serum levels of RF at baseline and at SVR‐12 or −24 to analyse the changes after eradication. This study enrolled 297 patients (median age, 59 years; female, 48.5%; cirrhosis, 16.8%). Among them, 78 (26.3%) were RF‐positive by qualitative serology at baseline. This number decreased to 49 (16.5%) at SVR‐12 or −24 (p < 0.001). Quantitatively, the median RF also decreased from 1.6 IU/mL (interquartile range [IQR], undetectable—15.8) to undetectable (IQR, undetectable—6.6 IU/mL) (p < 0.001). Significant reductions were observed in both groups. The proportion with RF seropositivity decreased from 24.3% to 15.4% (p = 0.001) in patients treated with interferon‐free agents (n = 214) and from 31.3% to 19.3% (p = 0.006) in patients treated with interferon‐based regimens (n = 83), without significant difference between two groups (p = 0.40). Serum RF decreased after HCV eradication, regardless of treatment regimen. Our findings suggest that HCV eradication may attenuate HCV‐related autoimmunity. [ABSTRACT FROM AUTHOR]

Published
2025
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9. Progression Rates by Age, Sex, Treatment, and Disease Activity by AASLD and EASL Criteria: Data for Precision Medicine

Author

Park, Jiyoon, Le, An K., Tseng, Tai-Chung, Yeh, Ming-Lun, Jun, Dae Won, Trinh, Huy, Wong, Grace L.H., Chen, Chien-Hung, Peng, Cheng-Yuan, Kim, Sung Eun, Oh, Hyunwoo, Kwak, Min-Sun, Cheung, Ka Shing, Toyoda, Hidenori, Hsu, Yao-Chun, Jeong, Jae Yoon, Yoon, Eileen L., Ungtrakul, Teerapat, Zhang, Jian, Xie, Qing, Ahn, Sang Bong, Enomoto, Masaru, Shim, Jae-Jun, Cunningham, Chris, Jeong, Soung Won, Cho, Yong Kyun, Ogawa, Eiichi, Huang, Rui, Lee, Dong-Hyun, Takahashi, Hirokazu, Tsai, Pei-Chien, Huang, Chung-Feng, Dai, Chia-Yen, Tseng, Cheng-Hao, Yasuda, Satoshi, Kozuka, Ritsuzo, Li, Jiayi, Wong, Christopher, Wong, Clifford C., Zhao, Changqing, Hoang, Joseph, Eguchi, Yuichiro, Wu, Chao, Tanaka, Yasuhito, Gane, Ed, Tanwandee, Tawesak, Cheung, Ramsey, Yuen, Man-Fung, Lee, Hyo-Suk, Yu, Ming-Lung, Kao, Jia-Horng, Yang, Hwai-I, and Nguyen, Mindie H.

Published
2022
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13. Bleeding Risk of Cold Versus Hot Snare Polypectomy for Pedunculated Colorectal Polyps Measuring 10 mm or Less: Subgroup Analysis of a Large Randomized Controlled Trial

Author

Tseng, Cheng-Hao, primary, Chang, Li-Chun, additional, Wu, Jia-Ling, additional, Chang, Chi-Yang, additional, Chen, Chi-Yi, additional, Chen, Peng-Jen, additional, Shun, Chia-Tung, additional, Hsu, Wen-Feng, additional, Chen, Yen-Nien, additional, Chen, Chieh-Chang, additional, Huang, Tien-Yu, additional, Tu, Chia-Hung, additional, Chen, Mei-Jyh, additional, Chou, Chu-Kuang, additional, Lee, Ching-Tai, additional, Chen, Po-Yueh, additional, Lin, Jaw-Town, additional, Wu, Ming-Shiang, additional, and Chiu, Han-Mo, additional

Published
2024
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14. A clinically interpretable convolutional neural network for the real-time prediction of early squamous cell cancer of the esophagus: comparing diagnostic performance with a panel of expert European and Asian endoscopists

Author

Everson, Martin A., Garcia-Peraza-Herrera, Luis, Wang, Hsiu-Po, Lee, Ching-Tai, Chung, Chen-Shuan, Hsieh, Ping-Hsin, Chen, Chien-Chuan, Tseng, Cheng-Hao, Hsu, Ming-Hung, Vercauteren, Tom, Ourselin, Sebastien, Kashin, Sergey, Bisschops, Raf, Pech, Oliver, Lovat, Laurence, Wang, Wen-Lun, and Haidry, Rehan J.

Published
2021
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15. Once-daily tenofovir disoproxil fumarate in treatment-naive Taiwanese patients with chronic hepatitis B and minimally raised alanine aminotransferase (TORCH-B): a multicentre, double-blind, placebo-controlled, parallel-group, randomised trial

Author

Hsu, Yao-Chun, Chen, Chi-Yi, Chang, I-Wei, Chang, Chi-Yang, Wu, Chun-Ying, Lee, Teng-Yu, Wu, Ming-Shiang, Bair, Ming-Jong, Chen, Jyh-Jou, Chen, Chieh-Chang, Tseng, Cheng-Hao, Tai, Chi-Ming, Huang, Yen-Tsung, Ku, Wen-Hui, Mo, Lein-Ray, and Lin, Jaw-Town

Published
2021
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20. Transition rates to cirrhosis and liver cancer by age, gender, disease and treatment status in Asian chronic hepatitis B patients

Author

Liu, Matt, Tseng, Tai-Chung, Jun, Dae Won, Yeh, Ming-Lun, Trinh, Huy, Wong, Grace L. H., Chen, Chien-Hung, Peng, Cheng-Yuan, Kim, Sung Eun, Oh, Hyunwoo, Kwak, Min-Sun, Cheung, Michael, Toyoda, Hidenori, Hsu, Yao-Chun, Jeong, Jae Yoon, Yoon, Eileen L., Ungtrakul, Teerapat, Zhang, Jian, Xie, Qing, Ahn, Sang Bong, Enomoto, Masaru, Shim, Jae-Jun, Cunningham, Chris, Jeong, Soung Won, Cho, Yong Kyun, Ogawa, Eiichi, Huang, Rui, Lee, Dong-Hyun, Takahashi, Hirokazu, Tsai, Pei-Chien, Huang, Chung-Feng, Dai, Chia-Yen, Tseng, Cheng-Hao, Yasuda, Satoshi, Kozuka, Ritsuzo, Li, Jiayi, Wong, Christopher, Wong, Clifford C., Zhao, Changqing, Hoang, Joseph, Eguchi, Yuichiro, Wu, Chao, Tanaka, Yasuhito, Gane, Ed, Tanwandee, Tawesak, Cheung, Ramsey, Yuen, Man-Fung, Lee, Hyo-Suk, Yu, Ming-Lung, Kao, Jia-Horng, Yang, Hwai-I., and Nguyen, Mindie H.

Published
2021
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21. Antiviral Therapy Utilization and 10-Year Outcomes in Resected Hepatitis B Virus– and Hepatitis C Virus–Related Hepatocellular Carcinoma

Author

Huang, Daniel Q., primary, Hoang, Joseph K., additional, Kamal, Rubayet, additional, Tsai, Pei-Chien, additional, Toyoda, Hidenori, additional, Yeh, Ming-Lun, additional, Yasuda, Satoshi, additional, Leong, Jennifer, additional, Maeda, Mayumi, additional, Huang, Chung-Feng, additional, Won Jun, Dae, additional, Ishigami, Masatoshi, additional, Tanaka, Yasuhito, additional, Uojima, Haruki, additional, Ogawa, Eiichi, additional, Abe, Hiroshi, additional, Hsu, Yao-Chun, additional, Tseng, Cheng-Hao, additional, Alsudaney, Manaf, additional, Yang, Ju Dong, additional, Yoshimaru, Yoko, additional, Suzuki, Takanori, additional, Liu, Joanne K., additional, Landis, Charles, additional, Dai, Chia-Yen, additional, Huang, Jee-Fu, additional, Chuang, Wan-Long, additional, Schwartz, Myron, additional, Dan, Yock Young, additional, Esquivel, Carlos, additional, Bonham, Andrew, additional, Yu, Ming-Lung, additional, and Nguyen, Mindie H., additional

Published
2024
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22. Racial and ethnic disparities in untreated patients with hepatitis C virus‐related hepatocellular carcinoma but not in those with sustained virologic response

Author

Park, Jung Eun, primary, Nguyen, Vy H., additional, Tsai, Pei‐Chien, additional, Toyoda, Hidenori, additional, Leong, Jennifer, additional, Guy, Jennifer E., additional, Yeh, Ming‐Lun, additional, Huang, Chung‐Feng, additional, Yasuda, Satoshi, additional, Abe, Hiroshi, additional, Hsu, Yao‐Chun, additional, Tseng, Cheng‐Hao, additional, Liu, Joanne, additional, Chen, Yao‐Li, additional, Lin, Ping‐Yi, additional, Jun, Dae Won, additional, Yoshimaru, Yoko, additional, Ogawa, Eiichi, additional, Ishigami, Masatoshi, additional, Enomoto, Masaru, additional, Tamori, Akihiro, additional, Uojima, Haruki, additional, Wang, Xiao Zhong, additional, Xu, Qiang, additional, Takahashi, Hirokazu, additional, Eguchi, Yuichiro, additional, Inoue, Kaori, additional, Huang, Daniel Q., additional, Zhao, Wen Jing, additional, Chuang, Wan‐Long, additional, Dai, Chia‐Yen, additional, Huang, Jee‐Fu, additional, Barnett, Scott, additional, Maeda, Mayumi, additional, Cheung, Ramsey, additional, Landis, Charles, additional, Tanaka, Yasuhito, additional, Roberts, Lewis R., additional, Schwartz, Myron E., additional, Kumada, Takashi, additional, Yu, Ming‐Lung, additional, and Nguyen, Mindie H., additional

Published
2024
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26. Direct-acting antivirals in East Asian hepatitis C patients: real-world experience from the REAL-C Consortium

Author

Huang, Chung-Feng, Iio, Etsuko, Jun, Dae Won, Ogawa, Eiichi, Toyoda, Hidenori, Hsu, Yao-Chun, Haga, Hiroaki, Iwane, Shinji, Enomoto, Masaru, Lee, Dong Hyun, Wong, Grace, Liu, Chen-Hua, Tada, Toshifumi, Chuang, Wan-Long, Cheung, Ramsey, Hayashi, Jun, Tseng, Cheng-Hao, Yasuda, Satoshi, Tran, Sally, Kam, Leslie, Henry, Linda, Jeong, Jae Yoon, Nomura, Hideyuki, Park, Seung Ha, Nakamuta, Makoto, Huang, Jee-Fu, Tai, Chi-Ming, Lo, Gin-Ho, Lee, Mei-Hsuan, Yang, Hwai-I, Kao, Jia-Horng, Tamori, Akihiro, Eguchi, Yuichiro, Ueno, Yoshiyuki, Furusyo, Norihiro, Tanaka, Yasuhito, Yu, Ming-Lung, and Nguyen, Mindie H.

Published
2019
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27. Sex differences in treatment response to nucleos(t)ide therapy in chronic hepatitis B: a multicenter longitudinal study

Author

Chau, Angela, primary, Yeh, Ming-Lun, additional, Tsai, Pei-Chien, additional, Huang, Daniel Q., additional, Kim, Sung Eun, additional, Trinh, Huy, additional, Yoon, Eileen L., additional, Oh, Hyunwoo, additional, Jeong, Jae Yoon, additional, Ahn, Sang Bong, additional, An, Jihyun, additional, Tseng, Cheng-Hao, additional, Hsu, Yao-Chun, additional, Jeong, Soung Won, additional, Cho, Yong Kyun, additional, Shim, Jae-Jun, additional, Kim, Hyoung Su, additional, Ito, Takanori, additional, Marciano, Sebastián, additional, Kawashima, Keigo, additional, Suzuki, Takanori, additional, Watanabe, Tsunamasa, additional, Nozaki, Akito, additional, Ishikawa, Toru, additional, Inoue, Kaori, additional, Eguchi, Yuichiro, additional, Uojima, Haruki, additional, Abe, Hiroshi, additional, Takahashi, Hirokazu, additional, Chuma, Makoto, additional, Ishigami, Masatoshi, additional, Hoang, Joseph K., additional, Mayumi, Maeda, additional, Huang, Chung-Feng, additional, Gadano, Adrian, additional, Dai, Chia-Yen, additional, Huang, Jee-Fu, additional, Tanaka, Yasuhito, additional, Chuang, Wan-Long, additional, Lim, Seng Gee, additional, Cheung, Ramsey, additional, Yu, Ming-Lung, additional, Jun, Dae-Won, additional, and Nguyen, Mindie H., additional

Published
2023
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31. Concomitant, bismuth quadruple, and 14-day triple therapy in the first-line treatment of Helicobacter pylori: a multicentre, open-label, randomised trial

Author

Liou, Jyh-Ming, Fang, Yu-Jen, Chen, Chieh-Chang, Bair, Ming-Jong, Chang, Chi-Yang, Lee, Yi-Chia, Chen, Mei-Jyh, Chen, Chien-Chuan, Tseng, Cheng-Hao, Hsu, Yao-Chun, Lee, Ji-Yuh, Yang, Tsung-Hua, Luo, Jiing-Chyuan, Chang, Chun-Chao, Chen, Chi-Yi, Chen, Po-Yueh, Shun, Chia-Tung, Hsu, Wen-Feng, Hu, Wen-Hao, Chen, Yen-Nien, Sheu, Bor-Shyang, Lin, Jaw-Town, Wu, Jeng-Yih, El-Omar, Emad M, and Wu, Ming-Shiang

Published
2016
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35. Increased spine bone density in patients with chronic hepatitis B switched to tenofovir alafenamide: A prospective, multinational study.

Author

Ogawa, Eiichi, Jun, Dae Won, Toyoda, Hidenori, Hsu, Yao‐Chun, Yoon, Eileen L., Ahn, Sang Bong, Yeh, Ming‐Lun, Do, Son, Trinh, Huy N., Takahashi, Hirokazu, Enomoto, Masaru, Kawada, Norifumi, Yasuda, Satoshi, Tseng, Cheng‐Hao, Kawashima, Keigo, Lee, Han Ah, Inoue, Kaori, Haga, Hiroaki, Do, Ai‐Thien, and Maeda, Mayumi

Subjects
CHRONIC hepatitis B, BONE density, SPINE, TENOFOVIR, ALANINE aminotransferase, GLOMERULAR filtration rate
Abstract

Summary: Background: Data on patients switched to tenofovir alafenamide (TAF) from nucleos(t)ide analogues (NUCs) other than tenofovir disoproxil fumarate are limited. Aims: To assess the treatment and renal/bone safety outcomes following the switch to TAF. Methods: We prospectively enrolled adult patients with chronic hepatitis B (CHB) who switched from any NUC to TAF at 14 centres in Japan, Korea, Taiwan and the U.S. Study outcomes were viral suppression (VR; HBV DNA < 20 IU/mL), biochemical response (BR; alanine aminotransferase normalisation), and changes in estimated glomerular filtration rate (eGFR) and T‐scores (L‐spine) by bone absorptiometry by 24 months after switch to TAF. Results: We enrolled 270 eligible patients. Mean age was 58.1; 58.2% were male; 12.2% had cirrhosis and 73.3% previously received entecavir monotherapy. VR rate increased significantly from 95.2% to 98.8% by 24 months after the switch to TAF (p = 0.014). Between the switch and 24 months later, the mean spine T‐score improved significantly from −1.43 ± 1.36 to −1.17 ± 1.38 (p < 0.0001), while there was no significant change in mean eGFR (88.4 ± 16.9–89.5 ± 16.3 mL/min/1.73 m2, p = 0.13). On multivariable analysis adjusted for age, sex, baseline spine T‐score and prior TDF or adefovir dipivoxil use, male sex was significantly associated with lower risk of worsening spine T‐score (odds ratio: 0.29, p = 0.020), while age was significantly associated with a higher risk of worsening chronic kidney disease stage (OR: 1.07, p = 0.019). Conclusions: At 24 months after the switch to TAF, VR rates and spine bone density improved significantly while renal function remained stable. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Medium-term surgical outcomes and health-related quality of life after laparoscopic vs open colorectal cancer resection: SF-36 health survey questionnaire

Author

Hung, Chao-Ming, primary, Hung, Kuo-Chuan, additional, Shi, Hon-Yi, additional, Su, Shih-Bin, additional, Lee, Hui-Ming, additional, Hsieh, Meng-Che, additional, Tseng, Cheng-Hao, additional, Lin, Shung-Eing, additional, Chen, Chih-Cheng, additional, Tseng, Chao-Ming, additional, Tsai, Ying-Nan, additional, Chen, Chi-Zen, additional, Tsai, Jung-Fa, additional, and Chiu, Chong-Chi, additional

Published
2023
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38. Cold Versus Hot Snare Polypectomy for Small Colorectal Polyps

Author

Chang, Li-Chun, primary, Chang, Chi-Yang, additional, Chen, Chi-Yi, additional, Tseng, Cheng-Hao, additional, Chen, Peng-Jen, additional, Shun, Chia-Tung, additional, Hsu, Wen-Feng, additional, Chen, Yen-Nien, additional, Chen, Chieh-Chang, additional, Huang, Tien-Yu, additional, Tu, Chia-Hung, additional, Chen, Mei-Jyh, additional, Chou, Chu-Kuang, additional, Lee, Ching-Tai, additional, Chen, Po-Yueh, additional, Wu, Ming-Shiang, additional, and Chiu, Han-Mo, additional

Published
2023
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41. Second-line levofloxacin-based quadruple therapy versus bismuth-based quadruple therapy for Helicobacter pylori eradication and long-term changes to the gut microbiota and antibiotic resistome: a multicentre, open-label, randomised controlled trial

Author

Liou, Jyh-Ming, primary, Jiang, Xiao-Tao, additional, Chen, Chieh-Chang, additional, Luo, Jiing-Chyuan, additional, Bair, Ming-Jong, additional, Chen, Po-Yueh, additional, Chou, Chu-Kuang, additional, Fang, Yu-Jen, additional, Chen, Mei-Jyh, additional, Chen, Chien-Chuan, additional, Lee, Ji-Yuh, additional, Yang, Tsung-Hua, additional, Yu, Chien-Chun, additional, Kuo, Chia-Chi, additional, Chiu, Min-Chin, additional, Chen, Chi-Yi, additional, Shun, Chia-Tung, additional, Hu, Wen-Hao, additional, Tsai, Min-Horn, additional, Hsu, Yao-Chun, additional, Tseng, Cheng-Hao, additional, Chang, Chi-Yang, additional, Lin, Jaw-Town, additional, El-Omar, Emad M, additional, Wu, Ming-Shiang, additional, Wu, Chun-Ying, additional, Lee, Yi-Chia, additional, Tseng, Ping-Huei, additional, Wu, Jeng-Yih, additional, Tai, Chi-Ming, additional, Lee, Ching-Tai, additional, and Wang, Wen-Lun, additional

Published
2022
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42. Severe hepatitis B flares with hepatic decompensation after withdrawal of nucleos(t)ide analogues: A population‐based cohort study.

Author

Hsu, Yao‐Chun, Lin, Yi‐Hsian, Lee, Teng‐Yu, Nguyen, Mindie H., Tseng, Cheng‐Hao, Ho, Hsiu J., Kao, Feng‐Yu, Lin, Jaw‐Town, Wu, Chen‐Yi, and Wu, Chun‐Ying

Subjects
CHRONIC hepatitis B, HEPATITIS B, PORTAL hypertension, COHORT analysis
Abstract

Summary: Background: Finite nucleos(t)ide analogue (NUC) therapy has been proposed as an alternative treatment strategy for chronic hepatitis B (CHB). Aim: To quantify the incidence of severe hepatitis flares following NUC cessation in everyday clinical practice. Methods: This population‐based cohort study enrolled 10,192 patients (male 71.7%, median age 50.9 years, cirrhosis 10.7%) who had received first‐line NUCs for at least 1 year before discontinuing treatment. The primary outcome was severe flare with hepatic decompensation. We used competing risk analyses to assess event incidences and associated risk factors. Results: During a median follow‐up of 2.2 years, 132 patients developed severe flares with hepatic decompensation, yielding a 4‐year cumulative incidence of 1.8% (95% confidence interval [CI], 1.5%–2.2%). Significant risk factors were cirrhosis (adjusted sub‐distributional hazard ratio [aSHR], 2.74; 95% CI, 1.82–4.12), manifestations of portal hypertension (aSHR, 2.46; 95% CI, 1.45–4.18), age (aSHR, 1.21 per 10 years; 95% CI, 1.03–1.42) and male sex (aSHR, 1.58; 95% CI, 1.04–2.38). In patients without cirrhosis or portal hypertension (n = 8863), the 4‐year cumulative incidence of severe withdrawal flares stood at 1.3% (95% CI, 1.0%–1.7%). For those patients with available data confirming adherence to the standard stopping rules (n = 1274), the incidence was 1.1% (95% CI, 0.6%–2.0%). Conclusions: Severe flares with hepatic decompensation were observed in 1%–2% of patients with CHB after stopping NUC therapy in daily practice. Risk factors included older age, cirrhosis, portal hypertension and male sex. Our findings argue against NUC cessation as part of routine clinical care. [ABSTRACT FROM AUTHOR]

Published
2023
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44. S1189 Safety and Efficacy of Oral TLR8 Agonist, Selgantolimod, in Viremic Adult Patients With Chronic Hepatitis B

Author

Janssen, Harry, primary, Lim, Young-Suk, additional, Kim, Hyung Joon, additional, Tseng, Cheng-Hao, additional, Coffin, Carla, additional, Elkashab, Magdy, additional, Ahn, Sang Hoon, additional, Nguyen, Anh-Hoa, additional, Chen, Diana, additional, Wallin, Jeffrey, additional, Tan, Susana, additional, Yang, Jenny, additional, Gaggar, Anuj, additional, Brainard, Diana, additional, Fung, Scott, additional, Kim, Yoon Jun, additional, Kao, Jia-Horng, additional, Chuang, Wan-Long, additional, Brooks, Anna, additional, and Dunbar, Rod, additional

Published
2022
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45. Reply

Author

Hsu, Yao-Chun, primary, Tseng, Cheng-Hao, additional, and Nguyen, Mindie H., additional

Published
2022
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47. Sequential versus triple therapy for the first-line treatment of Helicobacter pylori: a multicentre, open-label, randomised trial

Author

Liou, Jyh-Ming, Chen, Chieh-Chang, Chen, Mei-Jyh, Chen, Chien-Chuan, Chang, Chi-Yang, Fang, Yu-Jen, Lee, Ji–Yuh, Hsu, Shih-Jer, Luo, Jiing-Chyuan, Chang, Wen-Hsiung, Hsu, Yao-Chun, Tseng, Cheng-Hao, Tseng, Ping-Huei, Wang, Hsiu-Po, Yang, Ueng-Cheng, Shun, Chia-Tung, Lin, Jaw-Town, Lee, Yi-Chia, and Wu, Ming-Shiang

Published
2013
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49. Collaborative Referral Model to Achieve Hepatitis C Micro-Elimination in Methadone Maintenance Treatment Patients during the COVID-19 Pandemic

Author

Tai, Chi-Ming, primary, Huang, Chun-Kai, additional, Changchien, Te-Chang, additional, Lin, Po-Chun, additional, Wang, Deng-Wu, additional, Chang, Ting-Ting, additional, Chan, Hsue-Wei, additional, Chen, Tzu-Haw, additional, Tseng, Cheng-Hao, additional, Chen, Chih-Cheng, additional, Tsai, Chia-Ta, additional, Sie, Yu-Ting, additional, Yen, Yung-Chieh, additional, and Yu, Ming-Lung, additional

Published
2022
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50. Decrease in the burden of integrated hepatitis B virus DNA in chronic hepatitis B patients with minimally elevated alanine aminotransferase on tenofovir disoproxil fumarate as revealed by long-read DNA-sequencing

Author

Pan, David, primary, Soulette, Cameron, additional, Han, Dong, additional, Ramirez, Ricardo, additional, Van Buuren, Nicholas, additional, Lin, Jaw-Town, additional, Tseng, Cheng-Hao, additional, Li, Li, additional, Fletcher, Simon, additional, Mo, Hongmei, additional, Feierbach, Becket, additional, Suri, Vithika, additional, and Hsu, Yao-Chun, additional

Published
2022
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