40 results on '"Tsochev, Kaloyan"'
Search Results
2. Do parental risk factors for type 2 diabetes predict offspring risk of overweight and obesity? The Feel4Diabetes study
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Vitoratou, Dimitra-Irinna, Mavrogianni, Christina, Karatzi, Kalliopi, Cardon, Greet, Iotova, Violeta, Tsochev, Kaloyan, Lindström, Jaana, Wikström, Katja, González-Gil, Esther M., Moreno, Luis, Rurik, Imre, Radó, Anette IS, Tankova, Tsvetalina, Liatis, Stavros, Makrilakis, Konstantinos, and Manios, Yannis
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- 2023
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3. Association of diet quality with glycemia, insulinemia, and insulin resistance in families at high risk for type 2 diabetes mellitus in Europe: Feel4 Diabetes Study
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E, Botsi, K, Karatzi, C, Mavrogianni, Tsochev, Kaloyan, González-Gil, Esther M, S, Radó, J, Kivelä, K, Wikström, G, Cardon, I, Rurik, S, Liatis, Tankova, Tsvetalina, Iotova, Violeta, Moreno, Luis A., K, Makrillakis, Y, Manios, and C, Tsigos
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- 2023
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4. Association between Screen Time and Sociodemographic Factors, Physical Activity, and BMI among Children in Six European Countries (Feel4Diabetes): A Cross-Sectional Study
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Radó, Sándor Istvánné, primary, Molnár, Mónika, additional, Széll, Róbert, additional, Szőllősi, Gergő József, additional, Törő, Viktória, additional, Shehab, Bashar, additional, Manios, Yannis, additional, Anastasiou, Costas, additional, Iotova, Violeta, additional, Tsochev, Kaloyan, additional, Chakarova, Nevena, additional, Giménez-Legarre, Natalia, additional, Miguel Berges, Maria Luisa, additional, Schwarz, Peter E. H., additional, Rurik, Imre, additional, and Sárváry, Attila, additional
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- 2024
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5. Frequency of family meals and food consumption in families at high risk of type 2 diabetes: the Feel4Diabetes-study
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Mahmood, Lubna, González-Gil, Esther M., Schwarz, Peter, Herrmann, Sandra, Karaglani, Eva, Cardon, Greet, De Vylder, Flore, Willems, Ruben, Makrilakis, Konstantinos, Liatis, Stavors, Iotova, Violeta, Tsochev, Kaloyan, Tankova, Tsvetalina, Rurik, Imre, Radó, Sándorné, Moreno, Luis A., and Manios, Yannis
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- 2022
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6. Factors affecting continuous participation in follow‐up evaluations during a lifestyle intervention programme for type 2 diabetes prevention: The Feel4Diabetes‐study.
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Kourpas, Elias, Makrilakis, Konstantinos, Dafoulas, George, Iotova, Violeta, Tsochev, Kaloyan, Dimova, Roumyana, Cardon, Greet, González‐Gil, Esther M., Moreno, Luis, Kivelä, Jemina, Lindström, Jaana, Rurik, Imre, Antal, Emese, Timpel, Patrick, Schwartz, Peter, Mavrogianni, Christina, Manios, Yannis, Liatis, Stavros, Schwarz, Peter, and Annemans, Lieven
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COMMUNITY health services ,PATIENT compliance ,BEHAVIOR modification ,BODY mass index ,DATA analysis ,RESEARCH funding ,AT-risk people ,SOCIOECONOMIC factors ,SEX distribution ,DESCRIPTIVE statistics ,POPULATION geography ,TYPE 2 diabetes ,HEALTH behavior ,STATISTICS ,SOCIODEMOGRAPHIC factors ,BLOOD pressure ,PATIENT participation ,SCHOOL health services ,HEALTH care teams ,EDUCATIONAL attainment ,EMPLOYMENT ,SOCIAL classes - Abstract
Aim s : Community‐ and school‐based lifestyle interventions are an efficient method of preventing type 2 diabetes in vulnerable populations. Many participants, however, fail to complete the necessary follow‐ups. We investigated factors affecting the continuous participation in follow‐up evaluations during the Feel4Diabetes‐study, a multilevel intervention programme implemented across Europe. Methods: Socioeconomic, sociodemographic and clinical factors were assessed for 2702 participants within six participating countries: Bulgaria and Hungary (low‐to‐middle‐income countries, LMIC), Belgium and Finland (high‐income countries, HIC) and Greece and Spain (high‐income countries under austerity measures, HICAM). Results: Statistically significant differences were detected with respect to sex, control group, education level, employment status, BMI and blood pressure measurements (systolic and diastolic blood pressure). Post hoc analysis revealed significant differences within socioeconomic regions. Higher levels of education were associated with significantly lower attrition in HIC (p < 0.05) and HICAM (p < 0.001), higher employment status was associated with lower attrition in HICAM (p < 0.001) and being female was associated with lower attrition in LMIC (p < 0.001). Surprisingly, the intervention group exhibited higher‐than‐expected attrition in HIC (p < 0.001) and HICAM (p = 0.003), and lower attrition in LMIC (p = 0.007). When tested together in the same multivariable predictive model, all sociodemographic and socioeconomic variables along with higher BMI retained their statistical significance, while systolic and diastolic blood pressure failed to remain significant. Conclusions: Key socioeconomic and sociodemographic factors along with BMI play a significant role in determining continuous participation in follow‐up evaluations during school‐ and community‐based intervention programmes. [ABSTRACT FROM AUTHOR]
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- 2024
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7. Evaluation of the Finnish Diabetes Risk Score as a screening tool for undiagnosed type 2 diabetes and dysglycaemia among early middle-aged adults in a large-scale European cohort. The Feel4Diabetes-study
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Mavrogianni, Christina, Lambrinou, Christina-Paulina, Androutsos, Odysseas, Lindström, Jaana, Kivelä, Jemina, Cardon, Greet, Huys, Nele, Tsochev, Kaloyan, Iotova, Violeta, Chakarova, Nevena, Rurik, Imre, Moreno, Luis A., Liatis, Stavros, Makrilakis, Konstantinos, and Manios, Yannis
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- 2019
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8. Effectiveness, reach, uptake, and feasibility of digital health interventions for adults with hypertension: a systematic review and meta-analysis of randomised controlled trials
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Siopis, George, primary, Moschonis, George, additional, Eweka, Evette, additional, Jung, Jenny, additional, Kwasnicka, Dominika, additional, Asare, Bernard Yeboah-Asiamah, additional, Kodithuwakku, Vimarsha, additional, Willems, Ruben, additional, Verhaeghe, Nick, additional, Annemans, Lieven, additional, Vedanthan, Rajesh, additional, Oldenburg, Brian, additional, Manios, Yannis, additional, Gong, Enying, additional, Votis, Konstantinos, additional, Segkouli, Sofia, additional, Triantafyllidis, Andreas, additional, Kyparissis, Odysseas, additional, Paliokas, Ioannis, additional, Polychroniou, Eleftheria, additional, De Craemer, Dirk, additional, Anastasiou, Kostas, additional, Tserpes, Konstantinos, additional, Mavrogianni, Christina, additional, Karaglani, Eva, additional, Kalogerakou, Electra, additional, Maragkoudaki, Maria, additional, Ntzouvani, Agathi, additional, Kontochristopoulou, Katerina, additional, Dupont, Sabine, additional, Dupont, Elizabeth, additional, Dauzon, Leo, additional, Roskams, Maartje, additional, Lennox-Chhugani, Niamh, additional, Perrin, Martin, additional, Day, Niamh Daly, additional, Ferrer, Georgina, additional, Snook, Orla, additional, Aldasoro, Edelweiss, additional, Gil-Salmerón, Alejandro, additional, Peiró, Pilar Gangas, additional, Curran, Darren, additional, Lyne, Fiona, additional, Curreri, Nereide A., additional, Siopis, George, additional, Pierantozzi, Nazzareno, additional, D'Antonio, Claudia, additional, Vespasiani, Giacomo, additional, Almonti, Teresa, additional, Skouteris, Helen, additional, Taylor, Tracy, additional, Savaglio, Melissa, additional, Makrilakis, Konstantinos, additional, Stergiou, George, additional, Liatis, Stavros, additional, Karamanakos, George, additional, Koliaki, Chrysi, additional, Kollias, Anastasios, additional, Zikou, Eva, additional, Dimosthenopoulos, Haris, additional, Huang, Keng-Yen, additional, Adhikari, Samrachana, additional, Qian, Kun, additional, Dickhaus, Julia, additional, Carney, Kimberly, additional, Sahito, Farhan, additional, Pavlovic, Dusan, additional, Djokic, Djordje, additional, Sahito, Arzoo, additional, Battalova, Gisella, additional, Seghieri, Chiara, additional, Nutti, Sabina, additional, Vanieri, Milena, additional, Belle, Nicola, additional, Bertarelli, Gaia, additional, Cantarelli, Paola, additional, Ferre, Francesca, additional, Noci, Anna, additional, Tortu, Constanza, additional, Bozzi, Nadia, additional, Ferrari, Dina, additional, Borelli, Rachele, additional, Iotova, Violeta, additional, Yotov, Yoto, additional, Usheva, Natalia, additional, Kozhuharova, Anna, additional, Russeva, Vanya, additional, Marinova, Vanya, additional, Koleva, Sonya, additional, Atanasova, Virginia, additional, Stefanova, Tanya, additional, Tsochev, Kaloyan, additional, Aznar, Luis Moreno, additional, Botaya, Rosa Magallón, additional, Lozano, Gloria Bueno, additional, De Miguel-Etayo, Pilar, additional, Gonzalez-Gil, Esther Ma, additional, Miguel-Berges, María L., additional, Pérez, Susana, additional, Blázquez, Bárbara Oliván, additional, Giménez-Legarre, Natalia, additional, Toti, Florian, additional, Prifti, Skerdi, additional, Bombaj, Blerina, additional, Doracaj, Ditila, additional, Laze, Ornela, additional, Lapardhaja, Adriana, additional, and Bruka, Luftime, additional
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- 2023
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9. Effectiveness, reach, uptake, and feasibility of digital health interventions for adults with type 2 diabetes: a systematic review and meta-analysis of randomised controlled trials
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Moschonis, George, primary, Siopis, George, additional, Jung, Jenny, additional, Eweka, Evette, additional, Willems, Ruben, additional, Kwasnicka, Dominika, additional, Asare, Bernard Yeboah-Asiamah, additional, Kodithuwakku, Vimarsha, additional, Verhaeghe, Nick, additional, Vedanthan, Rajesh, additional, Annemans, Lieven, additional, Oldenburg, Brian, additional, Manios, Yannis, additional, Gong, Enying, additional, Votis, Konstantinos, additional, Segkouli, Sofia, additional, Triantafyllidis, Andreas, additional, Kyparissis, Odysseas, additional, Paliokas, Ioannis, additional, Polychroniou, Eleftheria, additional, De Craemer, Dirk, additional, Anastasiou, Kostas, additional, Tserpes, Konstantinos, additional, Mavrogianni, Christina, additional, Karaglani, Eva, additional, Kalogerakou, Electra, additional, Maragkoudaki, Maria, additional, Ntzouvani, Agathi, additional, Kontochristopoulou, Katerina, additional, Dupont, Sabine, additional, Dupont, Elizabeth, additional, Dauzon, Leo, additional, Roskams, Maartje, additional, Lennox-Chhugani, Niamh, additional, Perrin, Martin, additional, Day, Niamh Daly, additional, Ferrer, Georgina, additional, Snook, Orla, additional, Aldasoro, Edelweiss, additional, Gil-Salmerón, Alejandro, additional, Peiró, Pilar Gangas, additional, Curran, Darren, additional, Lyne, Fiona, additional, Curreri, Nereide A., additional, Moschonis, George, additional, Pierantozzi, Nazzareno, additional, D'Antonio, Claudia, additional, Vespasiani, Giacomo, additional, Almonti, Teresa, additional, Skouteris, Helen, additional, Taylor, Tracy, additional, Savaglio, Melissa, additional, Makrilakis, Konstantinos, additional, Stergiou, George, additional, Liatis, Stavros, additional, Karamanakos, George, additional, Koliaki, Chrysi, additional, Kollias, Anastasios, additional, Zikou, Eva, additional, Dimosthenopoulos, Haris, additional, Huang, Keng-Yen, additional, Adhikari, Samrachana, additional, Qian, Kun, additional, Dickhaus, Julia, additional, Carney, Kimberly, additional, Sahito, Farhan, additional, Pavlovic, Dusan, additional, Djokic, Djordje, additional, Sahito, Arzoo, additional, Battalova, Gisella, additional, Seghieri, Chiara, additional, Nutti, Sabina, additional, Vanieri, Milena, additional, Belle, Nicola, additional, Bertarelli, Gaia, additional, Cantarelli, Paola, additional, Ferre, Francesca, additional, Noci, Anna, additional, Tortu, Constanza, additional, Bozzi, Nadia, additional, Ferrari, Dina, additional, Borelli, Rachele, additional, Iotova, Violeta, additional, Yotov, Yoto, additional, Usheva, Natalia, additional, Kozhuharova, Anna, additional, Russeva, Vanya, additional, Marinova, Vanya, additional, Koleva, Sonya, additional, Atanasova, Virginia, additional, Stefanova, Tanya, additional, Tsochev, Kaloyan, additional, Aznar, Luis Moreno, additional, Botaya, Rosa Magallón, additional, Lozano, Gloria Bueno, additional, De Miguel-Etayo, Pilar, additional, Gonzalez-Gil, Esther Ma, additional, Miguel-Berges, María L., additional, Pérez, Susana, additional, Blázquez, Bárbara Oliván, additional, Giménez-Legarre, Natalia, additional, Toti, Florian, additional, Prifti, Skerdi, additional, Bombaj, Blerina, additional, Doracaj, Ditila, additional, Laze, Ornela, additional, Lapardhaja, Adriana, additional, and Bruka, Luftime, additional
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- 2023
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10. A lifestyle pattern characterized by high consumption of sweet and salty snacks, sugar sweetened beverages and sedentary time is associated with blood pressure in families at risk for type 2 diabetes mellitus in Europe. The Feel4Diabetes Study.
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Basdeki, Eirini D., primary, Karatzi, Kalliopi, additional, Arnaoutis, Giannis, additional, Makrilakis, Konstantinos, additional, Liatis, Stavros, additional, Cardon, Greet, additional, De Craemer, Marieke, additional, Iotova, Violeta, additional, Tsochev, Kaloyan, additional, Tankova, Tsvetalina, additional, Kivelä, Jemina, additional, Wikström, Katja, additional, Rurik, Imre, additional, Radó, Sándorné, additional, Miguel‐Berges, María L, additional, Gimenez‐Legarre, Natalia, additional, Moreno‐Aznar, Luis, additional, and Manios, Yannis, additional
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- 2023
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11. Screening for acid-labile subunit deficiency in patients with growth hormone deficiency at a tertiary pediatric endocrinology center
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Rankova, Kameliya, primary, Shefket, Sevim, additional, Tsochev, Kaloyan, additional, Yordanova, Nikolinka, additional, Bazdarska, Yuliya, additional, Bocheva, Yana, additional, and Iotova, Violeta, additional
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- 2022
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12. Noonan syndrome patients with short stature at a single paediatric endocrinology centre
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Zenker, Martin, Institute of Human Genetics, University Hospital Magdeburg, Galcheva, Sonya, Medical University of Varna, Yordanova, Nikolinka, Bazdarska, Yuliya, Mladenov, Vilhelm, Boyadzhiev, Vesselin, Stoicheva, Rositsa, Halvadzhiyan, Irina, Medical University of Pleven, Stoyanova, Milena, Iotova, Violeta, Tsochev, Kaloyan, and Deyanova, Yana
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Noonan syndrome ,growth hormone treatment ,growth velocity ,height gain - Abstract
Introduction: Noonan syndrome (NS) is caused by mutations in RAS/MAPK signalling pathway genes. Growth hormone (GH) treatment is an established yet not fully standardized treatment. Aim: The aim of this article is to assess the first 2 years of GH treatment in NS patients at a single centre.Patients and Methods: A total of 20 (16 males) NS clinically diagnosed regularly followed patients participated (2011–2020). Of these, 9 (45%) had cardiac defects, and 8 (40%) had short stature. Growth hormone deficiency (GHD) was confirmed in 5 patients who started GH treatment, and 2 were treated as short, small for gestational age children. Patients underwent anthropometry, clinical, laboratory and imaging investigations.Results: The mean age at NS diagnosis was 7.8 ± 3.4 years (1.3 ÷ 10.5), and at GH start 9.1 ± 1.5 years. At GH start, SDSheight was -3.42±0.58 (-4.1 ÷ -2.6), SDSweight -3.07 ± 0.58 (-3.73 ÷ -2.27), and SDSIGF1 -1.12 ± 0.98 (-2.44 ÷ 0.25). The mean BA at diagnosis was delayed by 2.6 ± 0.9 years. The GH starting dose was 0.035 ± 0.005 mg/kg/d, and changed little thereafter.The growth velocity for the 1st year of treatment was 8.9 ± 1.4 cm, and for the 2nd year 6.9±1.1 cm. The first year ΔSDSheight was 0.72 (p = 0.002), ΔSDSweight was 0.83 (p = 0.025), the 2nd year increments being insignificant. The 1st and 2nd year ΔSDSIGF1 were 1.70 (p = 0.007) and 0.25 (n.s.), resp. Bone age remained significantly delayed. No treatment side effects were observed.Conclusion: Our study showed that GH-treated NS patients follow the general growth patterns. In order to improve outcomes, the treatment should be further standardized.
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- 2022
13. Sociodemographic, anthropometric, and lifestyle correlates of prediabetes and type 2 diabetes in europe: The Feel4Diabetes study
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Kontochristopoulou, Aikaterini M., primary, Karatzi, Kalliopi, additional, Karaglani, Eva, additional, Cardon, Greet, additional, Kivelä, Jemina, additional, Wikström, Katja, additional, Iotova, Violeta, additional, Tsochev, Kaloyan, additional, Tankova, Tsvetalina, additional, Rurik, Imre, additional, Radone, Anett S., additional, Liatis, Stavros, additional, Makrilakis, Konstantinos, additional, Moreno, Luis A., additional, and Manios, Yannis, additional
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- 2022
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14. Dietary Behavior and Compliance to Bulgarian National Nutrition Guidelines in Patients With Type 1 Diabetes With Longstanding Disease
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Pancheva, Rouzha, primary, Dimitrov, Lyubomir, additional, Gillon-Keren, Michal, additional, Tsochev, Kaloyan, additional, Chalakova, Tatyana, additional, Usheva, Natalya, additional, Nikolova, Silviya, additional, Yotov, Yoto, additional, and Iotova, Violeta, additional
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- 2022
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15. Design and specific features of the Programme for Early Detection and Follow-Up of Full-Term and Preterm Children, Born Small for Their Gestational Age
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Stoyanova, Hristina, Trakia University, Stara Zagora, Mumdzhiev, Hristo, Petleshkova-Angelova, Penka, Medical University of Plovdiv, Krasteva-Vilmosh, Maya, Iotova, Violeta, Medical University of Varna, Pramatarova, Tanya, Neonatology Clinic, Dr. Ivan Seliminski Hospital, Sliven, Tsochev, Kaloyan, Krumova, Darina, Zlateva, Tanya, Medical University - Varna, Georgieva, Ralitsa, Medical University of Sofia, and Acknowledgements. The Program is run by the Bulgarian Neonatology Association and the Varna Pediatric Endocrine Society with support from The Pfizer Global Мedical Grants (ID: 64919053).
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small for gestational age, SGA, catch-up growth, short stature, timely diagnosis - Abstract
In 2007 the International Consensus for Management of Children Born Small for Their Gestational Age (SGA) was published. SGA birth is connected to many complications in different periods of life. Often in practice children born with small sizes are underestimated and not always referred timely to а pediatric endocrinologist. Thеse children represent а significant part of children with growth problems. In our country there is not enough information for the condition and algorithm for its follow-up. Having all this in mind, Varna Pediаtric Endocrine Society (VAPES) and Bulgarian Neonatology Association (BNА) created the Programme for Early Detection and Follow-Up of Full-Term and Pre-Term Children, Born SGA. The current publication presents the design of the study. The Programme is scientifically applied investigation for early detection of full-term and preterm SGA children, aiming to facilitate timely diagnosis of syndromes and conditions connected to SGA births and, if needed, to recommend additional testing, including genetic. Through the Programme we expect to update the data for the prevalence of SGA births and SGA children without postnatal catch-up in our country. At the end of the Programme, we will evaluate its cost-effectiveness and will create an algorithm for detection and treatment of these children.
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- 2022
16. ARTERIAL HYPERTENSION IN PATIENTS WITH LONG DURATION TYPE 1 DIABETES MELLITUS
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Chalakova, Tatiana, primary, Tsochev, Kaloyan, additional, Yotov, Yoto, additional, Bocheva, Yana, additional, Valchev, Georgi, additional, Usheva, Natalya, additional, and Iotova, Violeta, additional
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- 2022
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17. Can food parenting practices explain the association between parental education and children’s food intake? The Feel4Diabetes-study
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Flores-Barrantes, Paloma, primary, Mavrogianni, Christina, additional, Iglesia, Iris, additional, Mahmood, Lubna, additional, Willems, Ruben, additional, Cardon, Greet, additional, De Vylder, Flore, additional, Liatis, Stavros, additional, Makrilakis, Konstantinos, additional, Martinez, Remberto, additional, Schwarz, Peter, additional, Rurik, Imre, additional, Antal, Emese, additional, Iotova, Violeta, additional, Tsochev, Kaloyan, additional, Chakarova, Nevena, additional, Kivelä, Jemina, additional, Wikström, Katja, additional, Manios, Yannis, additional, and Moreno, Luis A, additional
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- 2022
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18. Noonan syndrome patients with short stature at a single paediatric endocrinology centre
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Deyanova, Yana, primary, Iotova, Violeta, additional, Stoyanova, Milena, additional, Halvadzhiyan, Irina, additional, Stoicheva, Rositsa, additional, Tsochev, Kaloyan, additional, Mladenov, Vilhelm, additional, Bazdarska, Yuliya, additional, Yordanova, Nikolinka, additional, Galcheva, Sonya, additional, Boyadzhiev, Vesselin, additional, and Zenker, Martin, additional
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- 2022
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19. Children's food choices are highly dependent on patterns of parenting practices and food availability at home in families at high risk for type 2 diabetes in Europe: Cross‐sectional results from the Feel4Diabetes study.
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Zannidi, Dimitra, Karatzi, Kalliopi, Karaglani, Eva, Liatis, Stavros, Cardon, Greet, Iotova, Violeta, Tsochev, Kaloyan, Chakarova, Nevyana, Moreno, Luis A., Flores‐Barrantes, Paloma, Radó, Sándorné, Rurik, Imre, Lindström, Jaana, Makrilakis, Konstantinos, and Manios, Yannis
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FOOD habits ,CROSS-sectional method ,FOOD security ,REGRESSION analysis ,FOOD preferences ,TYPE 2 diabetes ,RISK assessment ,PARENTING ,PHYSICAL activity ,RESEARCH funding ,QUESTIONNAIRES ,FACTOR analysis ,FAMILY relations ,DISEASE risk factors - Abstract
Background: Food parenting practices, behaviours and food availability at home are associated with children's food choices; however, these associations have been mainly studied for each parenting practice separately and focused mostly on healthy populations. The aim of the study was to identify patterns of parenting practices (including data regarding food availability at home, food and physical activity–related behaviours and rewards) and to investigate their cross‐sectional associations with children's food choices in families at high risk for type 2 diabetes (T2D). Methods: Data of parents and children (n = 2278), from the Feel4Diabetes study conducted in six European countries, were collected using validated questionnaires. The data analysed included children's food choices, food availability at home and food and physical activity–related parenting practices. Four patterns of parenting practices were identified using principal component analysis, and associations between those components and children's food choices were assessed using adjusted, individual linear regressions. Results: Parenting patterns focusing on unhealthy habits, such as allowing unhealthy snacks and unlimited screen time, providing higher availability of unhealthy foods at home, rewarding with snacks and screen time, were positively associated with children's unhealthy food choices (consumption of savoury/sweet snacks, fizzy drinks, etc.). The parenting patterns providing fruit/vegetables at home, consuming fruit, and being physically active with the child were positively associated with children's healthier food choices (consumption of fruit, vegetables, whole grain cereals, etc.). Conclusions: Public health initiatives should focus on high‐risk families for T2D, assisting them to adopt appropriate parenting practices and behaviours to promote healthier food choices for children. Key points: Food and lifestyle–related parenting practices are associated with children's food choices in healthy populations; little is known in families at high‐risk for type 2 diabetes (T2D).Four parenting patterns (PP1–PP4) in high‐risk families for T2D were created, including healthy or unhealthy food, physical activity and screen‐related habits, and food availability at home.A more authoritative parenting pattern (high availability of fruits and vegetables at home, consumption of fruit/vegetables with the child, being active with the child) was positively associated with healthy children's food choices, including fruit and vegetables, whole grains, and fish.More permissive and/or neglectful parenting patterns (allow and reward with screen time and unhealthy snack consumption, high availability of unhealthy foods) were positively associated with children's choices of sugary snacks and drinks, red meat, and non‐whole grains. [ABSTRACT FROM AUTHOR]
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- 2023
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20. Initial results from the treatment with growth hormone of short, small for gestational age children
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Krumova, Darina, Medical University of Varna, Zlateva, Tanya, Rankova, Kameliya, Tsochev, Kaloyan, Georgieva, Ralitsa, Medical University of Sofia, and Iotova, Violeta
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small for gestational age children, short stature, growth hormone - Abstract
Introduction: Growth is important indicator of a child`s health. According to the literature, every year between 3 and 7% children are born with birth length and/or weight less than the 10th percentile for the corresponding gestational age. From those born short for gestational age (SGA), one in every ten children cannot catch up in growth. Recently, these children are defined in the literature as “short, SGA children”. Namely, in those children, especially in those untreated, metabolic and cardiovascular changes can be seen with age. In Bulgaria there is still no reimbursement for growth hormone (GH) treatment of this indication, and treatment is supported by a nation-wide charity (The Bulgarian Christmas).Aim: The aim of this article is to assess patients born SGA, without catch-up growth, regarding the age at start of the treatment, duration and effect of growth hormone treatment.Patients and Methods: Patients’ data was collected retrospectively from the maintained VECRED record. Statistical analysis was conducted by means of the SPSS programme. The most important factors regarding growth hormone treatment efficacy were assessed.Results: Currently at the center there are 43 SGA patients with short stature at an average age of 10.3 ± 7.1 y (1.7–40.1), 26 (60.5%) at an average age of 10.3 ± 4.2 y (3.7–17.3) are treated with growth hormone and 17 (39.5%) are just followed. The average age when the GH treatment was initially started is 6.5 ± 3.7 y (1.4–12.1). The gender distribution of the group is nearly 1:1 (22 boys:21 girls). The most common specific diagnosis is Silver-Russell Syndrome (22, 51.2%), followed by Noonan syndrome (3, 6.9%), Di George Syndrome (2, 4.7%), Lowe syndrome, etc. On the average the treatment duration is 39.3 ± 30.2 months (4–120). From the start of the treatment until the current survey, the height of the patients has increased with 1.23 ± 1.8 SDS.Conclusion: Growth hormone treatment in short SGA children leads to good results and that is why it is currently an accepted standard worldwide. This is also confirmed by the current results.
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- 2021
21. Epicardial fat as an imaging biomarker in the assessment of cardiometabolic risk in patients with type 1 diabetes with a duration of over 15 years
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El Shemeri, Samar, Medical University Varna, Kaloyanova, Daniela, Medical University of Varna, Valchev, Georgi, Tsochev, Kaloyan, Chalakova, Tatyana, Usheva, Nataliya, Bocheva, Yana, and Iotova, Violeta
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type 1 diabetes mellitus, coronary risk, dyslipidemia, epicardial fat, obesity - Abstract
Diabetes mellitus is one of the most frequent metabolic diseases and is characterized by increased coronary risk. Data from epicardial fat quantification in long-term type 1 diabetes patients with poor control and healthy volunteers, performed with computed tomography and magnetic resonance tomography, is analyzed in relation to biochemical and anthropometric indicators. Statistically significant correlations are established between epicardial fat volume and body mass index in diabetic men, as well as between epicardial fat volume and dyslipidemic markers.
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- 2021
22. The role of education and its link to metabolic control in patients with type 1 diabetes mellitus with long duration
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El Shemeri, Samar, Medical University of Varna, Boyadzhieva, Mila, Chausheva, Gergana, Bocheva, Yana, Usheva, Nataliya, Chalakova, Tatyana, Iotova, Violeta, Tsochev, Kaloyan, Yotov, Yoto, and Проучването е подкрепено от Фонд „Научни изследвания' към Министерство на образованието и науката на България (договор ДН 13/3 от 14.12.2017г.) и Фонд „Наука' към МУ – Варна с договор 17022/2017 г.
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endocrine system diseases ,nutritional and metabolic diseases ,type 1 diabetes mellitus, metabolic control, socioeconomic factors - Abstract
Type 1 diabetes mellitus (T1DM) is a disease with constantly increasing incidence. Acquiring knowledge and diabetes skills is an invariable and important part of the disease treatment during all life cycles. The association between socioeconomic status and, in particular, the level of educational qualification and the metabolic control in patients with long-duration of T1DM is not enough studied. The results received in the current study show that there is, although weak, association between the level of education and the glycaemic control, the presence of dyslipidaemia, and obesity in patients with T1DM with long duration.
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- 2021
23. RISK OF CARDIOVASCULAR DISEASES IN PEOPLE WITH TYPE 1 DIABETES MELLITUS
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Chalakova, Tatyana, primary, Yotov, Yoto, additional, Tsochev, Kaloyan, additional, Bocheva, Yana, additional, Iotova, Violeta, additional, Usheva, Natalya, additional, Galcheva, Sonya, additional, and Valchev, Georgi, additional
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- 2021
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24. The role of education and its link to metabolic control in patients with type 1 diabetes mellitus with long duration
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Tsochev, Kaloyan, primary, Iotova, Violeta, additional, Chalakova, Tatyana, additional, Yotov, Yoto, additional, Bocheva, Yana, additional, Chausheva, Gergana, additional, Boyadzhieva, Mila, additional, El Shemeri, Samar, additional, and Usheva, Nataliya, additional
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- 2021
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25. Intra- and inter- observer reliability of anthropometric measurements and blood pressure in primary schoolchildren and adults: the Feel4Diabetes-study
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Androutsos, Odysseas, Anastasiou, Costas, Lambrinou, Christina-Paulina, Mavrogianni, Christina, Cardon, Greet, Van Stappen, Vicky, Kivelä, Jemina, Wikström, Katja, Moreno, Luis A., Iotova, Violeta, Tsochev, Kaloyan, Chakarova, Nevena, Ungvári, Tímea, Jancso, Zoltán, Makrilakis, Konstantinos, and Manios, Yannis
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Adult ,Male ,MULTICENTER ,Blood Pressure ,CHILDREN ,Health Promotion ,Community Networks ,Education ,Prediabetic State ,Families ,Endocrinology ,HARMONIZATION ,Risk Factors ,Preventive Health Services ,Medicine and Health Sciences ,Humans ,Body Weights and Measures ,Vulnerable ,Obesity ,Child ,Children ,Physical activity & health ,Randomized Controlled Trials as Topic ,School Health Services ,Observer Variation ,Schools ,Research ,Reproducibility of Results ,Blood Pressure Determination ,Type 2 diabetes ,General Medicine ,Reference Standards ,Europe ,Diabetes and Metabolism ,Diabetes Mellitus, Type 2 ,Research Design ,Female - Abstract
Background: Feel4Diabetes was a large-scale, multicenter lifestyle intervention aiming to prevent type 2 diabetes among families from vulnerable population groups in six European countries (Belgium, Bulgaria, Finland, Greece, Hungary and Spain). The current study aimed to describe the process that was followed to harmonize and standardize the measurement of anthropometric (weight, height and waist circumference) and blood pressure (systolic and diastolic) indices, as well as to assess the intra- A nd inter-observer reliability of these measurements. Methods: A central training workshop was conducted prior to the baseline measurements of the Feel4Diabetes-intervention. One researcher from each intervention country, as well as 12 adults and 12 children (for the anthropometric measurements) and 21 adults (for the blood pressure measurements) participated in this workshop. Technical Error of Measurement (TEM) and reliability (%R) were calculated to assess the reliability of the indices which were assessed to evaluate the outcome of the Feel4Diabetes-intervention. The Feel4Diabetes-intervention is registered at http://clinicaltrials.gov/(NCT02393872). Results: Intra-observer reliability was found to be higher than 99.5% for all anthropometric measurements in both children and adults. Inter-observer reliability was found to be higher than 98% regarding the anthropometric measurements, while for blood pressure measurements %R was 76.62 and 91.38% for systolic and diastolic blood pressure measurements, respectively. Conclusion: The central training of the Fee4Diabetes-intervention ensured that the data collected for the outcome evaluation of the Feel4Diabetes-intervention in the six European countries at three different time points (baseline, follow-up 1 and follow-up 2) were valid and comparable.
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- 2020
26. Two-stage, school and community-based population screening successfully identifies individuals and families at high-risk for type 2 diabetes : the Feel4Diabetes-study
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Manios, Yannis, on behalf of the Feel4Diabetes-study group, [missing], Mavrogianni, Christina, Lambrinou, Christina-Paulina, Cardon, Greet, Lindström, Jaana, Iotova, Violeta, Tankova, Tsvetalina, Civeira, Fernando, Kivelä, Jemina, Jancsó, Zoltán, Shadid, Samyah, Tsochev, Kaloyan, Mateo-Gallego, Rocío, Radó, Sándorné, Dafoulas, George, Makrilakis, Konstantinos, and Androutsos, Odysseas
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Male ,Endocrinology, Diabetes and Metabolism ,Type 2 diabetes ,GUIDELINES ,lcsh:Diseases of the endocrine glands. Clinical endocrinology ,Community Networks ,MELLITUS ,0302 clinical medicine ,Endocrinology ,Residence Characteristics ,Risk Factors ,Preventive Health Services ,Prevalence ,Medicine and Health Sciences ,Mass Screening ,030212 general & internal medicine ,Prediabetes ,Child ,OUTCOMES ,Schools ,General Medicine ,Middle Aged ,3. Good health ,PREVALENCE ,Europe ,Diabetes and Metabolism ,Hypertension ,Screening ,Vulnerable groups ,Female ,LIFE-STYLE ,CHILDHOOD OBESITY ,School-based ,Adult ,medicine.medical_specialty ,AWARENESS ,030209 endocrinology & metabolism ,Vulnerable Populations ,Childhood obesity ,Prediabetic State ,03 medical and health sciences ,PEOPLE ,medicine ,Humans ,Family ,Socioeconomic status ,Implementation Science ,School Health Services ,lcsh:RC648-665 ,physical activity & health ,HYPERTENSION ,business.industry ,Public health ,Research ,MORTALITY ,Anthropometry ,medicine.disease ,Impaired fasting glucose ,Blood pressure ,Diabetes Mellitus, Type 2 ,Feasibility Studies ,business ,Demography ,Program Evaluation - Abstract
Background The implementation of population screening and early prevention strategies targeting individuals at high-risk for type 2 diabetes (T2D) seems to be a public health priority. The current work aimed to describe the screening procedure applied in the Feel4Diabetes-study and examine its effectiveness in identifying individuals and families at high risk, primarily for T2D and secondarily for hypertension, among vulnerable populations in low to middle-income countries (LMICs) and high-income countries (HICs) across Europe. Methods A two-stage screening procedure, using primary schools as the entry-point to the community, was applied in low socioeconomic status (SES) regions in LMICs (Bulgaria-Hungary), HICs (Belgium-Finland) and HICs under austerity measures (Greece-Spain). During the first-stage screening via the school-setting, a total of 20,501 parents (mothers and/or fathers) of schoolchildren from 11,396 families completed the Finnish Diabetes Risk Score (FINDRISC) questionnaire, while their children underwent anthropometric measurements in the school setting. Parents from the identified “high-risk families” (n = 4484) were invited to participate in the second-stage screening, including the measurement of fasting plasma glucose (FPG) and blood pressure (BP). In total, 3153 parents participated in the second-stage screening (mean age 41.1 ± 5.6 years, 65.8% females). Results Among parents who attended the second-stage screening, the prevalence of prediabetes (as defined by impaired fasting glucose; FPG 100-125 mg/dl) and T2D (FPG > 126 mg/dl) was 23.2 and 3.0% respectively, and it was found to be higher in the higher FINDRISC categories. The percentage of undiagnosed T2D among the participants identified with T2D was 53.5%. The prevalence of high normal BP (systolic BP 130-139 mmHg and/ or diastolic BP 85-89 mmHg) and hypertension (systolic BP ≥ 140 mmHg and/ or diastolic BP ≥ 90 mmHg) was 14 and 18.6% respectively, which was also higher in the higher FINDRISC categories. The percentage of cases not receiving antihypertensive treatment among the participants identified with hypertension was 80.3%. Conclusion The findings of the current study indicate that the two-stage school and community-based screening procedure followed, effectively identified high-risk individuals and families in vulnerable populations across Europe. This approach could be potentially scalable and sustainable and support initiatives for the early prevention of T2D and hypertension. Trial registration The Feel4Diabetes-intervention is registered at https://clinicaltrials.gov/ (NCT02393872; date of trial registration: March 20, 2015).
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- 2020
27. Sociodemographic and lifestyle-related risk factors for identifying vulnerable groups for type 2 diabetes : a narrative review with emphasis on data from Europe
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Kyrou, Ioannis, on behalf of the Feel4Diabetes-study Group, [missing], Tsigos, Constantine, Mavrogianni, Christina, Cardon, Greet, Van Stappen, Vicky, Latomme, Julie, Kivelä, Jemina, Wikström, Katja, Tsochev, Kaloyan, Nanasi, Anna, Semanova, Csilla, Mateo-Gallego, Rocío, Lamiquiz-Moneo, Itziar, Dafoulas, George, Timpel, Patrick, Schwarz, Peter E. H., Iotova, Violeta, Tankova, Tsvetalina, Makrilakis, Konstantinos, and Manios, Yannis
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endocrine system diseases ,Endocrinology, Diabetes and Metabolism ,Psychological intervention ,Ethnic group ,Review ,lcsh:Diseases of the endocrine glands. Clinical endocrinology ,FAMILY-HISTORY ,0302 clinical medicine ,Endocrinology ,CARDIOMETABOLIC RISK ,Prevalence ,Medicine and Health Sciences ,Ethnicity ,Medicine ,SOCIOECONOMIC-STATUS ,030212 general & internal medicine ,Prediabetes ,education.field_of_study ,INSULIN-RESISTANCE ,CARDIOVASCULAR RISK ,Type 2 diabetes ,General Medicine ,3. Good health ,Europe ,Diabetes and Metabolism ,MEDITERRANEAN DIET ,Type 2 Diabetes ,Risk Factors ,Socioeconomic Status ,Obesity ,Lifestyle ,Diet ,Socioeconomic status ,WAIST CIRCUMFERENCE ,Population ageing ,medicine.medical_specialty ,Population ,030209 endocrinology & metabolism ,Vulnerable Populations ,Prediabetic State ,03 medical and health sciences ,Environmental health ,Humans ,education ,Life Style ,Physical activity & health ,lcsh:RC648-665 ,business.industry ,Public health ,Type 2 Diabetes Mellitus ,nutritional and metabolic diseases ,FAT DISTRIBUTION ,medicine.disease ,BODY-MASS INDEX ,PHYSICAL-ACTIVITY ,Diabetes Mellitus, Type 2 ,Socioeconomic Factors ,Risk factors ,business - Abstract
Background Type 2 diabetes mellitus (T2DM) comprises the vast majority of all diabetes cases in adults, with alarmingly increasing prevalence over the past few decades worldwide. A particularly heavy healthcare burden of diabetes is noted in Europe, where 8.8% of the population aged 20–79 years is estimated to have diabetes according to the International Diabetes Federation. Multiple risk factors are implicated in the pathogenesis of T2DM with complex underlying interplay and intricate gene-environment interactions. Thus, intense research has been focused on studying the role of T2DM risk factors and on identifying vulnerable groups for T2DM in the general population which can then be targeted for prevention interventions. Methods For this narrative review, we conducted a comprehensive search of the existing literature on T2DM risk factors, focusing on studies in adult cohorts from European countries which were published in English after January 2000. Results Multiple lifestyle-related and sociodemographic factors were identified as related to high T2DM risk, including age, ethnicity, family history, low socioeconomic status, obesity, metabolic syndrome and each of its components, as well as certain unhealthy lifestyle behaviors. As Europe has an increasingly aging population, multiple migrant and ethnic minority groups and significant socioeconomic diversity both within and across different countries, this review focuses not only on modifiable T2DM risk factors, but also on the impact of pertinent demographic and socioeconomic factors. Conclusion In addition to other T2DM risk factors, low socioeconomic status can significantly increase the risk for prediabetes and T2DM, but is often overlooked. In multinational and multicultural regions such as Europe, a holistic approach, which will take into account both traditional and socioeconomic/socioecological factors, is becoming increasingly crucial in order to implement multidimensional public health programs and integrated community-based interventions for effective T2DM prevention.
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- 2020
28. Correlation between coronary calcium score and epicardial fat in patients with long-term type 1 diabetes and healthy controls – preliminary results
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Valchev, Georgi, primary, El Shemeri, Samar, additional, Kaloyanova, Daniela, additional, Chalakova, Tatyana, additional, Tsochev, Kaloyan, additional, Usheva, Nataliya, additional, Bocheva, Yana, additional, Boyadzhieva, Mila, additional, Yotov, Yoto, additional, and Iotova, Violeta, additional
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- 2020
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29. Socio-Demographic Characteristics and Body Weight Perceptions of Study Participants Benefitting Most from the Feel4Diabetes Program Based on Their Anthropometric and Glycaemic Profile Changes
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Moschonis, George, primary, Karatzi, Kalliopi, additional, Apergi, Kyriaki, additional, Liatis, Stavros, additional, Kivelä, Jemina, additional, Wikström, Katja, additional, Ayala-Marín, Alelí M., additional, Mateo-Gallego, Rocio, additional, Tsochev, Kaloyan, additional, Chakarova, Nevena, additional, Antal, Emese, additional, Rurik, Imre, additional, Iotova, Violeta, additional, Cardon, Greet, additional, Lindstrom, Jaana, additional, Moreno, Luis A., additional, Makrilakis, Konstantinos, additional, and Manios, Yannis, additional
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- 2020
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30. Mortality in childhood-onset type 1 diabetes
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Hadzhieva, Elitsa, primary, Boyadzhieva, Mila, additional, Iotova, Violeta, additional, Galcheva, Sonya, additional, Tsochev, Kaloyan, additional, Chalykova, Tatiana, additional, Yotov, Yoto, additional, Balev, Boyan, additional, Bocheva, Yana, additional, Usheva, Nataliya, additional, and Pancheva, Ruzha, additional
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- 2019
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31. Design and specific features of a study of the long term cardiovascular and metabolic risk in type 1 diabetes mellitus
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Tsochev, Kaloyan, primary, Chalakova, Tatyana, additional, Yotov, Yoto, additional, Bocheva, Yana, additional, Usheva, Natalya, additional, Boyadzhieva, Mila, additional, Galcheva, Sonya, additional, Iotova, Violeta, additional, and Stefanova, Tanya, additional
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- 2019
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32. Effective strategies for childhood obesity prevention via school based, family involved interventions: a critical review for the development of the Feel4Diabetes-study school based component.
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Lambrinou, Christina-Paulina, Androutsos, Odysseas, Karaglani, Eva, Cardon, Greet, Huys, Nele, Wikström, Katja, Kivelä, Jemina, Ko, Winne, Karuranga, Ernest, Tsochev, Kaloyan, Iotova, Violeta, Dimova, Roumyana, De Miguel-Etayo, Pilar, M. González-Gil, Esther, Tamás, Hajnalka, JANCSÓ, Zoltán, Liatis, Stavros, Makrilakis, Konstantinos, Manios, Yannis, and on behalf of the Feel4Diabetes-study group
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PREVENTION of childhood obesity ,CINAHL database ,FOOD preferences ,GREY literature ,HEALTH behavior ,HEALTH promotion ,INTERPROFESSIONAL relations ,MEDLINE ,ONLINE information services ,POLICY sciences ,SCHOOL health services ,SYSTEMATIC reviews ,SEDENTARY lifestyles ,PHYSICAL activity ,FAMILY attitudes - Abstract
Background: Although there are many interventions targeting childhood obesity prevention, only few have demonstrated positive results. The current review aimed to gather and evaluate available school-based intervention studies with family involvement targeting dietary, physical activity and sedentary behaviors among primary schoolchildren and their families, in order to identify the most effective strategies. Methods: Studies published between 2000 and January 2015 were retrieved from scientific electronic databases and grey literature. The databases used included MEDLINE/PubMed, Web-of-Science, CINAHL and Scopus. Included studies had to be experimental controlled studies and had duration over 1 school year, had family involvement, combined PA and dietary behaviors and were implemented in school setting. A complementary search was executed to update the review to cover the period from February 2015 to January 2019. Results: From the studies examined (n = 425), 27 intervention programs (33 publications) fulfilled the inclusion criteria. Among these, 15 presented significant effect on weight status and/ or overweight/ obesity or clinical indices, 3 presented significant effect on most energy balance-related behaviors (EBRBs) while 9 presented significant effect on some/few EBRBs or determinants. Strategies implemented in effective interventions were: teachers acting as role-models and being actively involved in the delivery of the intervention, school policies supporting the availability of healthy food and beverage choices and limiting unhealthy snacks, changes in the schoolyard, in the recess rules and in the physical education classes to increase physical activity, and involving parents in the intervention via assignments, meetings, informative material and encouraging them to improve the home environment. Use of incentives for children, social marketing techniques, collaboration with local stakeholders were found to increase effectiveness. Programs that focused only on educational sessions and material for parents, without promoting relevant environmental and policy changes, were found to be less effective. Cultural adaptations have been suggested to increase the intervention's acceptance in specific or vulnerable population groups. Conclusions: Several effective strategies were identified in the reviewed programs. Outcomes of the current review were taken into account in developing the Feel4Diabetes-intervention and summed up as recommendations in the current work in order to facilitate other researchers designing similar childhood obesity prevention initiatives. [ABSTRACT FROM AUTHOR]
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- 2020
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33. Methodology of the health economic evaluation of the Feel4Diabetes-study.
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Willems, Ruben, Pil, Lore, Lambrinou, Christina-Paulina, Kivelä, Jemina, Wikström, Katja, Gonzalez-Gil, Esther M., De Miguel-Etayo, Pilar, Nánási, Anna, Semánová, Csilla, Van Stappen, Vicky, Cardon, Greet, Tsochev, Kaloyan, Iotova, Violeta, Chakarova, Nevena, Makrilakis, Konstantinos, Dafoulas, George, Timpel, Patrick, Schwarz, Peter, Manios, Yannis, and Annemans, Lieven
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TYPE 2 diabetes prevention ,BEHAVIOR modification ,COST effectiveness ,HEALTH behavior ,MEDICAL care costs ,HEALTH policy ,TYPE 2 diabetes ,WEIGHT gain ,SOCIOECONOMIC factors ,PHYSICAL activity ,DATA analysis software - Abstract
Background: The clinical and economic burden of type 2 diabetes mellitus on society is rising. Effective and efficient preventive measures may stop the increasing prevalence, given that type 2 diabetes mellitus is mainly a lifestyle-driven disease. The Feel4Diabetes-study aimed to tackle unhealthy lifestyle (unhealthy diet, lack of physical activity, sedentary behaviour, and excess weight) of families with a child in the first grades of elementary school. These schools were located in regions with a relatively low socio-economic status in Belgium, Bulgaria, Finland, Greece, Hungary and Spain. Special attention was paid to families with a high risk of developing type 2 diabetes mellitus. Methods: The aim of this paper is to describe the detailed methodology of the intervention's cost-effectiveness analysis. Based on the health economic evaluation of the Toybox-study, both a decision analytic part and a Markov model have been designed to assess the long-term (time horizon of 70 year with one-year cycles) intervention's value for money. Data sources used for the calculation of health state incidences, transition probabilities between health states, health state costs, and health state utilities are listed. Intervention-related costs were collected by questionnaires and diaries, and attributed to either all families or high risk families only. Conclusions: The optimal use of limited resources is pivotal. The future results of the health economic evaluation of the Feel4Diabetes-study will contribute to the efficient use of those resources. [ABSTRACT FROM AUTHOR]
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- 2020
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34. Obtaining evidence base for the development of Feel4Diabetes intervention to prevent type 2 diabetes – a narrative literature review.
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Kivelä, Jemina, Wikström, Katja, Virtanen, Eeva, Georgoulis, Michael, Cardon, Greet, Civeira, Fernando, Iotova, Violeta, Karuranga, Ernest, Ko, Winne, Liatis, Stavros, Makrilakis, Konstantinos, Manios, Yannis, Mateo-Gallego, Rocío, Nanasi, Anna, Rurik, Imre, Tankova, Tsvetalina, Tsochev, Kaloyan, Van Stappen, Vicky, Lindström, Jaana, and on behalf of the Feel4Diabetes research group
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TYPE 2 diabetes prevention ,PREVENTION of obesity ,HEALTH promotion ,SOCIOECONOMIC factors ,AT-risk people ,HUMAN services programs - Abstract
Background: Feel4Diabetes was a school and community based intervention aiming to promote healthy lifestyle and tackle obesity for the prevention of type 2 diabetes among families in 6 European countries. We conducted this literature review in order to guide the development of evidence-based implementation of the Feel4Diabetes intervention. We focused on type 2 diabetes prevention strategies, including all the phases from risk identification to implementation and maintenance. Special focus was given to prevention among vulnerable groups and people under 45 years. Methods: Scientific and grey literature published between January 2000 and January 2015 was searched for relevant studies using electronic databases. To present the literature review findings in a systematic way, we used the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework. A complementary literature search from February 2015 to December 2018 was also conducted. Results: The initial review included 27 studies with a follow-up ≥12 months and 9 studies with a follow-up ≥6 months and with a participant mean age < 45 years. We found out that interventions should be targeted at people at risk to improve recruiting and intervention effectiveness. Screening questionnaires (primarily Finnish Diabetes Risk Score FINDRISC) and blood glucose measurement can both be used for screening; the method does not appear to affect intervention effectiveness. Screening and recruitment is time-consuming, especially when targeting lower socioeconomic status and age under 45 years. The intervention intensity is more important for effectiveness than the mode of delivery. Moderate changes in several lifestyle habits lead to good intervention results. A minimum of 3-year follow-up seemed to be required to show a reduction in diabetes risk in high-risk individuals. In participants < 45 years, the achieved results in outcomes were less pronounced. The complementary review included 12 studies, with similar results regarding intervention targets and delivery modes, as well as clinical significance. Conclusion: This narrative review highlighted several important aspects that subsequently guided the development of the Feel4Diabetes high-risk intervention. Research on diabetes prevention interventions targeted at younger adults or vulnerable population groups is still relatively scarce. Feel4Diabetes is a good example of a project aiming to fill this research gap. Trial registration: clinicaltrials.gov NCT02393872, registered 20th March 2015. [ABSTRACT FROM AUTHOR]
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- 2020
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35. Lipidemic Profile Changes over a Two-Year Intervention Period: Who Benefited Most from the Feel4Diabetes Program?
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Karatzi, Kalliopi, Moschonis, George, Botsi, Eirini, Liatis, Stavros, Tsochev, Kaloyan, De Miguel-Etayo, Pilar, Kivelä, Jemina, Wikström, Katja, Dimova, Roumyana, Antal, Emese, Lamiquiz-Moneo, Itziar, Rurik, Imre, Cardon, Greet, Iotova, Violeta, Makrilakis, Konstantinos, and Manios, Yannis
- Abstract
Identification of participants' characteristics who benefited most from large community-based intervention studies may guide future prevention initiatives in order to maximize their effectiveness. The current study aimed to examine the socio-demographic, anthropometric, and behavioral characteristics, as well as the health and eating perceptions of those who improved their lipidemic profile, in the Feel4Diabetes early screening and prevention program. In the present analyses, 1773 adults from families at high risk for developing type 2 diabetes mellitus (T2DM) were enrolled, receiving either the standard care or the more intensive intervention, and 33.3–55.2% of them improved one or more of their lipidemic indices by >5%. Women, people living in Southeastern Europe, coming from two-parent families, having higher financial security, educational level and better diet quality were associated with a 27–64% higher likelihood for benefiting from the program regarding one or more of their lipidemic profile indices. Participants who were overweight or obese (especially with central obesity), employed, with prolonged sedentary behavior, prone to emotional eating and perceiving their weight status as lower than their actual weight were 24–43% less likely to have benefited. These findings should guide future interventions, prioritizing regions in greater need, and being tailor-made to specific population characteristics in order to further improve their effectiveness. [ABSTRACT FROM AUTHOR]
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- 2020
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36. Development and Validation of Two Self-Reported Tools for Insulin Resistance and Hypertension Risk Assessment in A European Cohort: The Feel4Diabetes-Study.
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Kanellakis, Spyridon, Mavrogianni, Christina, Karatzi, Kalliopi, Lindstrom, Jaana, Cardon, Greet, Iotova, Violeta, Wikström, Katja, Shadid, Samyah, Moreno, Luis A., Tsochev, Kaloyan, Bíró, Éva, Dimova, Rumyana, Antal, Emese, Liatis, Stavros, Makrilakis, Konstantinos, and Manios, Yannis
- Abstract
Early identification of type 2 diabetes mellitus (T2DM) and hypertension (HTN) risk may improve prevention and promote public health. Implementation of self-reported scores for risk assessment provides an alternative cost-effective tool. The study aimed to develop and validate two easy-to-apply screening tools identifying high-risk individuals for insulin resistance (IR) and HTN in a European cohort. Sociodemographic, lifestyle, anthropometric and clinical data obtained from 1581 and 1350 adults (baseline data from the Feel4Diabetes-study) were used for the European IR and the European HTN risk assessment index respectively. Body mass index, waist circumference, sex, age, breakfast consumption, alcohol, legumes and sugary drinks intake, physical activity and sedentary behavior were significantly correlated with Homeostatic Model Assessment of IR (HOMA-IR) and/or HTN and incorporated in the two models. For the IR index, the Area Under the Curve (AUC), sensitivity and specificity for identifying individuals above the 75th and 95th of HOMA-IR percentiles were 0.768 (95%CI: 0.721–0.815), 0.720 and 0.691 and 0.828 (95%CI: 0.766–0.890), 0.696 and 0.778 respectively. For the HTN index, the AUC, sensitivity and specificity were 0.778 (95%CI: 0.680–0.876), 0.667 and 0.797. The developed risk assessment tools are easy-to-apply, valid, and low-cost, identifying European adults at high risk for developing T2DM or having HTN. [ABSTRACT FROM AUTHOR]
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- 2020
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37. Additional file 1 of Methodology of the health economic evaluation of the Feel4Diabetes-study
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Willems, Ruben, Pil, Lore, Christina-Paulina Lambrinou, Kivelä, Jemina, Wikström, Katja, Gonzalez-Gil, Esther M., Miguel-Etayo, Pilar De, Nánási, Anna, Semánová, Csilla, Stappen, Vicky Van, Cardon, Greet, Tsochev, Kaloyan, Iotova, Violeta, Chakarova, Nevena, Makrilakis, Konstantinos, Dafoulas, George, Timpel, Patrick, Schwarz, Peter, Manios, Yannis, and Annemans, Lieven
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3. Good health - Abstract
Additional file 1: Supplementary material can be found online. Table S1. Disease costs, stratified for age and country. Table S2. Disease-specific utility values, stratified for age and country.
38. Additional file 1 of Effective strategies for childhood obesity prevention via school based, family involved interventions: a critical review for the development of the Feel4Diabetes-study school based component
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Christina-Paulina Lambrinou, Androutsos, Odysseas, Karaglani, Eva, Cardon, Greet, Huys, Nele, Wikström, Katja, Kivelä, Jemina, Winne Ko, Karuranga, Ernest, Tsochev, Kaloyan, Iotova, Violeta, Roumyana Dimova, Miguel-Etayo, Pilar De, González-Gil, Esther M., Tamás, Hajnalka, JANCSÓ, Zoltán, Liatis, Stavros, Makrilakis, Konstantinos, and Manios, Yannis
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3. Good health - Abstract
Additional file 1: Table 1 PICO keywords.
39. Additional file 1 of Effective strategies for childhood obesity prevention via school based, family involved interventions: a critical review for the development of the Feel4Diabetes-study school based component
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Christina-Paulina Lambrinou, Androutsos, Odysseas, Karaglani, Eva, Cardon, Greet, Huys, Nele, Wikström, Katja, Kivelä, Jemina, Winne Ko, Karuranga, Ernest, Tsochev, Kaloyan, Iotova, Violeta, Roumyana Dimova, Miguel-Etayo, Pilar De, González-Gil, Esther M., Tamás, Hajnalka, JANCSÓ, Zoltán, Liatis, Stavros, Makrilakis, Konstantinos, and Manios, Yannis
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3. Good health - Abstract
Additional file 1: Table 1 PICO keywords.
40. Additional file 1 of Methodology of the health economic evaluation of the Feel4Diabetes-study
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Willems, Ruben, Pil, Lore, Christina-Paulina Lambrinou, Kivelä, Jemina, Wikström, Katja, Gonzalez-Gil, Esther M., Miguel-Etayo, Pilar De, Nánási, Anna, Semánová, Csilla, Stappen, Vicky Van, Cardon, Greet, Tsochev, Kaloyan, Iotova, Violeta, Chakarova, Nevena, Makrilakis, Konstantinos, Dafoulas, George, Timpel, Patrick, Schwarz, Peter, Manios, Yannis, and Annemans, Lieven
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3. Good health - Abstract
Additional file 1: Supplementary material can be found online. Table S1. Disease costs, stratified for age and country. Table S2. Disease-specific utility values, stratified for age and country.
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