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Background: The presence of tumor‐infiltrating lymphocytes (TILs) is associated with improved survival in head and neck squamous cell carcinoma. However, the prognostic value of TILs remains unclear in oral squamous cell carcinoma (OSCC). Methods: We evaluated the associations between tumor‐infiltrating CD8+ T‐cell density and survival in five distinct compartments in 139 OSCC cases. Results: There was a significant association between increased tumor‐infiltrating CD8+ T cells and their distribution. High parenchymal CD8+ T‐cell density at the invading tumor edge was associated with improved overall survival (OS) and disease‐specific survival (DSS; P < 0.01 and P < 0.01, respectively). High stromal CD8+ T‐cell density at the tumor periphery was also associated with improved recurrence‐free survival (RFS; P < 0.01). Cox regression analysis revealed that high stromal CD8+ T‐cell density at the tumor periphery and high parenchymal CD8+ T‐cell density at the invading edge were independent prognostic makers (hazard ratio: 0.38 and 0.19, 95% confidence interval, 0.18‐0.80 and 0.05‐0.72, P = 0.01 and 0.01, respectively) for RFS and OS, respectively. Conclusions: Assessment of CD8+ T cells at the parenchyma of the invading edge and peripheral stroma provides an indicator of tumor recurrence and prognosis. Assessment of CD8+ T cells at the parenchyma of the invading edge and peripheral stroma provides an indicator of tumor recurrence and prognosis. [ABSTRACT FROM AUTHOR]

Background/aim: The role of tumour-infiltrating CD45Ro + T-cells in oral squamous cell carcinoma (OSCC) is unclear. This study aimed to evaluate prognostic biomarkers for OSCC., Patients and Methods: We determined the density of tumour-infiltrating CD45Ro + T cells in the parenchyma and stroma at the tumour centre (TCe) and invasive front (IF) and examined the association between the density of these cells and histopathological status in 142 patients., Results: Five-year overall survival (OS) and recurrence-free survival were favourable in patients with high CD45Ro + T-cell density in the TCe stroma. OS was favourable in patients with high CD45Ro + T-cell density in the IF stroma. Stepwise Cox regression model analysis indicated that CD45Ro + T-cells in the stroma of the IF and TCe were an independent prognostic factor for OS., Conclusion: CD45Ro + T-cells in the stroma of the IF and TCe play a role in cancer immune surveillance and may be a useful prognostic factor., (Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)

Background: The presence of tumor-infiltrating lymphocytes (TILs) is associated with improved survival in head and neck squamous cell carcinoma. However, the prognostic value of TILs remains unclear in oral squamous cell carcinoma (OSCC)., Methods: We evaluated the associations between tumor-infiltrating CD8 + T-cell density and survival in five distinct compartments in 139 OSCC cases., Results: There was a significant association between increased tumor-infiltrating CD8 + T cells and their distribution. High parenchymal CD8 + T-cell density at the invading tumor edge was associated with improved overall survival (OS) and disease-specific survival (DSS; P < 0.01 and P < 0.01, respectively). High stromal CD8 + T-cell density at the tumor periphery was also associated with improved recurrence-free survival (RFS; P < 0.01). Cox regression analysis revealed that high stromal CD8 + T-cell density at the tumor periphery and high parenchymal CD8 + T-cell density at the invading edge were independent prognostic makers (hazard ratio: 0.38 and 0.19, 95% confidence interval, 0.18-0.80 and 0.05-0.72, P = 0.01 and 0.01, respectively) for RFS and OS, respectively., Conclusions: Assessment of CD8 + T cells at the parenchyma of the invading edge and peripheral stroma provides an indicator of tumor recurrence and prognosis., (© 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.)