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42 results on '"Tsukikawa, Satoshi"'

10. A Spontaneously Ruptured Leiomyoma of the Appendix

Author

Mafune, Taichi, primary, Tsukikawa, Satoshi, additional, Tsuchiya, Junichi, additional, Shimada, Jin, additional, Saji, Osamu, additional, Horikoshi, Kuniyasu, additional, Makizumi, Ryouji, additional, Hanai, Akira, additional, Takagi, Masayuki, additional, and Otsubo, Takehito, additional

Published
2016
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12. Evaluating distribution of the left branch of the middle colic artery and the left colic artery by CT angiography and colonography to classify blood supply to the splenic flexure.

Author

Fukuoka, Asako, Sasaki, Takahiro, Tsukikawa, Satoshi, Miyajima, Nobuyoshi, and Ostubo, Takehito

Subjects
COLON cancer diagnosis, VIRTUAL colonoscopy, ANGIOGRAPHY, PREOPERATIVE care, SPLENIC artery, SURGERY
Abstract

Introduction CT angiography has gained widespread acceptance for preoperative evaluation of blood supply in patients with colorectal cancer. However, there have been few reports that pertain to the splenic flexure, for which surgery is technically difficult. We used preoperative CT angiography and CT colonography to evaluate blood supply to the splenic flexure. Methods We defined the splenic flexure as the junction of the distal third of the transverse colon and the proximal third of the descending colon. We reviewed 191 cases and considered the descending colon as divided into the proximal third and the distal two-thirds; we then determined which part of the descending colon the left colic artery (LCA) entered. We also considered the transverse colon as divided into the proximal two-thirds and the distal third, and evaluated which part of the transverse colon the left branch of the middle colic artery entered. Result We classified blood supply to the splenic flexure into six types, described by the feeder vessels: type 1, the LCA (39.7%); type 2, the left branch of the middle colic artery (17.8%); type 3, the LCA and the left branch of the middle colic artery (9.9%); type 4, the accessory left colic artery (4.1%); type 5, the LCA and the accessory left colic artery (2.6%); and type 6, the marginal artery (25.6%). Conclusion We classified blood supply to the splenic flexure into more complex types than previous reports had. Because we dissect the lymph nodes according to the type of blood supply, knowing the type before splenic flexure surgery is crucial. [ABSTRACT FROM AUTHOR]

Published
2017
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14. Incarcerated hernia in two patients on peritoneal dialysis

Author

Sakurada, Tsutomu, primary, Yube, Yukinori, additional, Noda, Akiyoshi, additional, Nakano, Hiroshi, additional, Tsukikawa, Satoshi, additional, Otsubo, Takehito, additional, Murasawa, Masaru, additional, Oishi, Daisuke, additional, Ichikawa, Daisuke, additional, Tominaga, Naoto, additional, Shibagaki, Yugo, additional, and Kimura, Kenjiro, additional

Published
2015
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15. Cardiac Metastasis from Ascending Colon Cancer: A Case Report and Review of the Literature

Author

Mikami, Shinya, primary, Tsuchiya, Junichi, additional, Horikoshi, Kuniyasu, additional, Makizumi, Ryoji, additional, Shimamura, Tsukasa, additional, Hanai, Akira, additional, Tsukikawa, Satoshi, additional, Koizumi, Hirotaka, additional, Fukunaga, Tetsu, additional, Kokuba, Yukihito, additional, Miyajima, Nobuyoshi, additional, and Otsubo, Takehito, additional

Published
2015
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39. Thermoreversible gelation on cooling and on heating of an aqueous gelatin–poly(N-isopropylacrylamide) conjugate

Author

Yoshioka, Hiroshi, Mori, Yuichi, Tsukikawa, Satoshi, and Kubota, Sunao

Abstract

A polymer conjugate composed of 43 wt% gelatin and 57 wt% poly(N-isopropylacrylamide) (PNIPAAm) was prepared. The dynamic viscoelastic properties of an aqueous solution of the conjugate at the concentration of 5 wt% were examined. The solution was viscous fluid at 30°C and turned into an elastic homogeneous hydrogel upon heating above 34°C or upon cooling below 10°C. The resultant hydrogels turned back into a solution at the opposite temperature cycles of the gelation. It is considered that the driving force of the gelation is the intermolecular hydrophobic interaction of PNIPAAm blocks or the intermolecular helix association of gelatin blocks, respectively, on heating or on cooling. © 1998 John Wiley & Sons, Ltd.

Published
1998
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40. [A case of unknown primary cancer responding to chemotherapy selected based on the results of an anticancer drug sensitivity test].

Author

Miura K, Tsukikawa S, Nishio K, Katagiri H, Sakurai J, Shimamura T, Makizumi R, and Otsubo T

Subjects
Antineoplastic Combined Chemotherapy Protocols administration & dosage, Ascites drug therapy, Ascites etiology, Biopsy, Cisplatin administration & dosage, Fluorouracil administration & dosage, Humans, Male, Middle Aged, Neoplasms, Unknown Primary complications, Neoplasms, Unknown Primary pathology, Neoplasms, Unknown Primary surgery, Tomography, X-Ray Computed, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Cisplatin therapeutic use, Fluorouracil therapeutic use, Neoplasms, Unknown Primary drug therapy
Abstract

Case: The patient was a 64-year-old man. In 1998, he underwent proximal gastrectomy for gastric cancer. In September 2007, follow-up CT revealed multiple tumors around the hilum of the spleen, and he was referred to our hospital. On the initial consultation, the marked retention of ascites was noted. The levels of tumor markers such as PIVKA-II and a-fetoprotein were markedly increased. Despite various examinations, the primary focus could not be determined. In November 2007, an exploratory laparotomy was performed, but the primary focus was unclear, so one of the nodules of the major omentum was excisionally biopsied. An anticancer drug sensitivity test showed that the specimen was sensitive to 5-FU and CDDP. Therefore, the combined chemotherapy with 5-FU and CDDP was performed. The patient responded to this therapy. Ascites and tumor markers remarkably decreased, and the performance status improved from 3 to 1., Conclusion: These results suggest the usefulness of an anticancer drug sensitivity test in the treatment of cancer in which the primary focus is unclear.

Published
2010

41. [A case report of complete response to RPMI regimen for multiple lymph node metastases following rectal cancer surgery].

Author

Segami K, Sakurai J, Noda A, Suwa T, Enomoto T, Kobayashi S, Makizumi R, Tsukikawa S, Yamada K, Miyajima N, and Otsubo T

Subjects
Aged, Biomarkers, Tumor blood, Humans, Lymphatic Metastasis diagnostic imaging, Lymphatic Metastasis pathology, Male, Positron-Emission Tomography, Rectal Neoplasms blood, Rectal Neoplasms surgery, Remission Induction, Tomography, X-Ray Computed, Antineoplastic Agents therapeutic use, Fluorouracil therapeutic use, Leucovorin therapeutic use, Rectal Neoplasms drug therapy, Rectal Neoplasms pathology
Abstract

A 78-year old man underwent low anterior resection for Stage IIIb rectal cancer(Ra). After surgery, he underwent the Roswell Park Memorial Institute(RPMI)regimen for 6 months followed by oral UFT for 8 months. Since liver metastasis(S6)recurred 2 years and 2 months after surgery, he underwent S6 subsegmentectomy. Four years and 4 months later, he developed multiple lymph node metastases(the Virchow, paraaortic, and intrapelvic lymph nodes), for which FOLFIRI therapy was started, but converted to the RPMI regimen because of strong gastrointestinal side effects. After 3 courses of this regimen, tumor markers returned to normal, and imaging studies showed that the metastases had disappeared. This was interpreted as a complete response(CR). The patient has maintained the complete response for 1 year and 4 months since the start of the RPMI regimen.

Published
2009

42. New chemosensitivity test using a thermo-reversible gelation polymer for recurrent gynecologic cancer patients and a preliminary study of mechanisms of anticancer drug resistance.

Author

Ohara T, Kiguchi K, Tsukikawa S, Sato S, Kobayashi Y, Ishizuka B, and Kubota S

Subjects
Cell Culture Techniques, Drug Resistance, Neoplasm, Female, Gels, Humans, Multidrug Resistance-Associated Protein 2, Neoplasm Recurrence, Local, Polymers, Temperature, Tumor Cells, Cultured, Antineoplastic Agents pharmacology, Culture Media, Drug Screening Assays, Antitumor methods, Genital Neoplasms, Female pathology
Abstract

Objectives: TGP (thermo-reversible gelation polymer) is a high molecular compound that has so-gel transmitting temperature of 221C Since solid cancer tissue grows in this polymer three-dimensionally, and fibroblasts scarcely grow in it, TGP is suitable for chemosensitivity assays for solid tumors. In this study, a chemosensitivity test using TGP was applied to recurrent gynecologic cancer patients in order to evaluate its utility and efficacy. In some ovarian cancer cases, expression of anticancer drug resistance-related proteins was also analyzed., Methods: Recurrent tumor tissues were surgically obtained with informed consent. After these tissues were minced and incubated for 4 days with CDDP, mitomycin C, 5-fluorouracil, paclitaxel, and CPT-11, the sensitivity against these drugs was estimated. Western blotting was performed in 8 recurrent ovarian cancer tissues in order to analyze the expression of Bcl-2, MRP2, BCRP, and GST-pi., Results: The total evaluability rate of this assay was 90.6% (29/32). Sensitive drugs could be determined in 5 of 7 ascites samples (71.4%) and in 2 of 3 intra-tumoral fluid samples (66.7%). The overall clinical response rate of chemotherapy determined by these results was 50.0%. There were significant correlations between the IC50 of CDDP and Bcl-2, BCRP, GST-pi, and between that of 5-FU and MRP 2., Conclusions: Although this was a preliminary study, the chemosensitivity test using this new material appears to be useful for designing 'made-to order' salvage chemotherapy for pretreated recurrent gynecologic patients. In order to overcome multidrug resistance, the mechanisms of multidrug resistance should be further investigated.

Published
2005
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