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Your search keyword '"Tsutsumi, Shinobu"' showing total 15 results
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15 results on '"Tsutsumi, Shinobu"'

2. Oil pollution in the straits of Malacca, Malaysia: application of molecular markers for source identification

Author

Zakaria, Mohamad Pauzi, Horinouchi, Ai, Tsutsumi, Shinobu, Takada, Hideshige, Tanabe, Shinsuke, and Ismail, Ahmad

Subjects
Pollution control industry -- Research, Environmental issues, Science and technology
Abstract

Researchers from Malaysia and Japan collected tar ball samples from the coast of the Straits of Malacca, Malaysia to determine the exact source of oil spills. The process involves the use of triterpanes, a biomarker compounds utility that can pinpoint the source of the oil spill.

Published
2000

3. Intercalibration of LABs in Marine Sediment SRM1941a and Their Application as a Molecular Marker in Narragansett Bay Sediments

Author

Hartmann, Paul C., Quinn, James G., King, John W., Tsutsumi, Shinobu, and Takada, Hideshige

Subjects
United States. National Institute of Standards and Technology -- Research, Alkylbenzene sulfonate -- Research, Chemical industry -- Research, Soap and cleaning agents industry -- Environmental aspects, Environmental issues, Science and technology
Abstract

A calibration study between two laboratories tracked the flow of sewage and pollutants in Narragansett Bay by using linear alkylbenzenes as markers.

Published
2000

7. Low concentrations of sodium dodecyl sulfate induce the extension of beta2-microglobulin-related amyloid fibrils at a neutral pH

Author

Yamamoto, Suguru, Hasegawa, Kazuhiro, Yamaguchi, Itaru, Tsutsumi, Shinobu, Kardos, Jozsef, Goto, Yuji, Gejyo, Fumitake, and Naiki, Hironobu

Subjects
Circular dichroism -- Analysis, Hydrogen-ion concentration -- Analysis, Fluorescence spectroscopy -- Analysis, Biological sciences, Chemistry
Abstract

The effects of sodium dodecyl sulfate (SDS) and other detergents on the conformation of beta2-m, the stability of Abeta2M amyloid fibrils, and the extension of amyloid fibrils at neutral pH, are investigated using fluorescence spectroscopy with thioflavin T (ThT), circular dichroism (CD) spectroscopy and electron microscopy. The findings display the sensitivity of Abeta2M fibril formation to solution conditions and suggest a possible role for lipid molecules in the development of Abeta2M amyloidosis.

Published
2004

8. Distribution of polycyclic aromatic hydrocarbons (PAHs) in rivers and estuaries in Malaysia: a widespread input of petrogenic PAHs

Author

Zakaria, Mohamad Pauzi, Takada, Hideshige, Tsutsumi, Shinobu, Ohno, Kei, Yamada, Junya, Kouno, Eriko, Kumata, Hidetoshi, Zakaria, Mohamad Pauzi, Takada, Hideshige, Tsutsumi, Shinobu, Ohno, Kei, Yamada, Junya, Kouno, Eriko, and Kumata, Hidetoshi

Abstract

This is the first publication on the distribution and sources of polycyclic aromatic hydrocarbons (PAHs) in riverine and coastal sediments in South East Asia where the rapid transfer of land-based pollutants into aquatic environments by heavy rainfall and runoff waters is of great concern. Twenty-nine Malaysian riverine and coastal sediments were analyzed for PAHs (3−7 rings) by gas chromatography mass spectrometry. Total PAHs concentra tions in the sediment ranged from 4 to 924 ng/g. Alkylated homologues were abundant for all sediment samples. The ratio of the sum of methylphenanthrenes to phenanthrene (MP/P), an index of petrogenic PAHs contribution, was more than unity for 26 sediment samples and more than 3 for seven samples for urban rivers covering a broad range of locations. The MP/P ratio showed a strong correlation with the total PAHs concentrations, with an r2 value of 0.74. This ratio and all other compositional features indicated that Malaysian urban sediments are heavily impacted by petrogenic PAHs. This finding is in contrast to other studies reported in many industrialized countries where PAHs are mostly of pyrogenic origin. The MP/P ratio was also significantly correlated with higher molecular weight PAHs such as benzo[a]pyrene, suggesting unique PAHs source in Malaysia which contains both petrogenic PAHs and pyrogenic PAHs. PAHs and hopanes fingerprints indicated that used crankcase oil is one of the major contributors of the sedimentary PAHs. Two major routes of inputs to aquatic environments have been identified: (1) spillage and dumping of waste crankcase oil and (2) leakage of crankcase oils from vehicles onto road surfaces, with the subsequent washout by street runoff. N-Cyclohexyl-2-benzothiazolamine (NCBA), a molecular marker of street dust, was detected in the polluted sediments. NCBA and other biomarker profiles confirmed our hypothesis of the input from street dust contained the leaked crankcase oil. The fingerprints excluded crude oil, f

Published
2002

15. Glycosaminoglycans enhance the trifluoroethanol-induced extension of beta 2-microglobulin-related amyloid fibrils at a neutral pH.

Author

Yamamoto S, Yamaguchi I, Hasegawa K, Tsutsumi S, Goto Y, Gejyo F, and Naiki H

Subjects
Amyloid drug effects, Hydrogen-Ion Concentration, beta 2-Microglobulin drug effects, Amyloid metabolism, Glycosaminoglycans pharmacology, Trifluoroethanol pharmacology, beta 2-Microglobulin metabolism
Abstract

beta(2)-Microglobulin-related (A beta 2M) amyloidosis is a frequent and serious complication in patients on long-term dialysis, and beta(2)-microglobulin is a major structural component of A beta 2M amyloid fibrils. Several biologic molecules inhibiting the depolymerization of A beta 2M amyloid fibrils at a neutral pH were found recently. The effect of trifluoroethanol and glycosaminoglycans (GAG) on the extension of the fibrils at a neutral pH was investigated with the use of fluorescence spectroscopy with thioflavin T, circular dichroism spectroscopy, and electron microscopy. Trifluoroethanol at concentrations of up to 20% (vol/vol) caused fibril extension of heparin-stabilized seeds, inducing a subtle change in the tertiary structure of beta(2)-microglobulin and stabilizing the fibrils at a neutral pH. This extension reaction followed a first-order kinetic model. In addition, some GAG, especially heparin, dose-dependently enhanced the fibril extension. These results suggest that some GAG, especially heparin, may bind to the fibrils and enhance their deposition in vivo. Thus, the experimental system described here should be useful to search for the factors that accelerate A beta 2M amyloid deposition in vivo. In addition, the interference of the binding of GAG to A beta 2M amyloid fibrils may be an attractive therapeutic modality.

Published
2004
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