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1,759 results on '"Tu, Jian"'

19. Systematic transcriptome profiling of hPSC-derived osteoblasts unveils CORIN's mastery in governing osteogenesis through CEBPD modulation

Author

Zhu, Dandan, Huang, Mo-Fan, Xu, An, Gao, Xueqin, Huang, Yu-Wen, Phan, Trinh T.T., Lu, Linchao, Chi, Ting-Yen, Dai, Yulin, Pang, Lon Kai, Gingold, Julian A., Tu, Jian, Huo, Zijun, Bazer, Danielle A., Shoemaker, Rachel, Wang, Jun, Ambrose, Catherine G., Shen, Jingnan, Kameoka, Jun, Zhao, Zhongming, Wang, Lisa L., Zhang, Yang, Zhao, Ruiying, and Lee, Dung-Fang

Published
2024
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29. Rewired m6A epitranscriptomic networks link mutant p53 to neoplastic transformation

Author

Xu, An, Liu, Mo, Huang, Mo-Fan, Zhang, Yang, Hu, Ruifeng, Gingold, Julian A., Liu, Ying, Zhu, Dandan, Chien, Chian-Shiu, Wang, Wei-Chen, Liao, Zian, Yuan, Fei, Hsu, Chih-Wei, Tu, Jian, Yu, Yao, Rosen, Taylor, Xiong, Feng, Jia, Peilin, Yang, Yi-Ping, Bazer, Danielle A., Chen, Ya-Wen, Li, Wenbo, Huff, Chad D., Zhu, Jay-Jiguang, Aguilo, Francesca, Chiou, Shih-Hwa, Boles, Nathan C., Lai, Chien-Chen, Hung, Mien-Chie, Zhao, Zhongming, Van Nostrand, Eric L., Zhao, Ruiying, and Lee, Dung-Fang

Published
2023
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49. Reciprocal Regulation Between Forkhead Box M1/NF‐κB and Methionine Adenosyltransferase 1A Drives Liver Cancer

Author

Li, Yuan, Lu, Liqing, Tu, Jian, Zhang, Jing, Xiong, Ting, Fan, Wei, Wang, Jiaohong, Li, Meng, Chen, Yibu, Steggerda, Justin, Peng, Hui, Chen, Yongheng, Li, Tony WH, Zhou, Zhi‐Gang, Mato, José M, Seki, Ekihiro, Liu, Ting, Yang, Heping, and Lu, Shelly C

Subjects
Chronic Liver Disease and Cirrhosis, Rare Diseases, Liver Disease, Cancer, Digestive Diseases, Liver Cancer, Genetics, Animals, Carcinogenesis, Cell Line, Tumor, Datasets as Topic, Feedback, Physiological, Forkhead Box Protein M1, Gene Expression Regulation, Neoplastic, Hepatocytes, Humans, Hydrocarbons, Fluorinated, Liver, Liver Neoplasms, Male, Methionine Adenosyltransferase, Mice, Mice, Knockout, NF-kappa B, Primary Cell Culture, Promoter Regions, Genetic, Pyridines, S-Adenosylmethionine, Sulfonamides, Thiophenes, Tumor Suppressor Proteins, Xenograft Model Antitumor Assays, Medical Biochemistry and Metabolomics, Clinical Sciences, Immunology, Gastroenterology & Hepatology
Abstract

Background and aimsForkhead box M1 (FOXM1) and nuclear factor kappa B (NF-ĸB) are oncogenic drivers in liver cancer that positively regulate each other. We showed that methionine adenosyltransferase 1A (MAT1A) is a tumor suppressor in the liver and inhibits NF-ĸB activity. Here, we examined the interplay between FOXM1/NF-κB and MAT1A in liver cancer.Approach and resultsWe examined gene and protein expression, effects on promoter activities and binding of proteins to promoter regions, as well as effects of FOXM1 inhibitors T0901317 (T0) and forkhead domain inhibitory-6 (FDI-6) in vitro and in xenograft and syngeneic models of liver cancer. We found, in both hepatocellular carcinoma and cholangiocarcinoma, that an induction in FOXM1 and NF-κB expression is accompanied by a fall in MATα1 (protein encoded by MAT1A). The Cancer Genome Atlas data set confirmed the inverse correlation between FOXM1 and MAT1A. Interestingly, FOXM1 directly interacts with MATα1 and they negatively regulate each other. In contrast, FOXM1 positively regulates p50 and p65 expression through MATα1, given that the effect is lost in its absence. FOXM1, MATα1, and NF-κB all bind to the FOX binding sites in the FOXM1 and MAT1A promoters. However, binding of FOXM1 and NF-κB repressed MAT1A promoter activity, but activated the FOXM1 promoter. In contrast, binding of MATα1 repressed the FOXM1 promoter. MATα1 also binds and represses the NF-κB element in the presence of p65 or p50. Inhibiting FOXM1 with either T0 or FDI-6 inhibited liver cancer cell growth in vitro and in vivo. However, inhibiting FOXM1 had minimal effects in liver cancer cells that do not express MAT1A.ConclusionsWe have found a crosstalk between FOXM1/NF-κB and MAT1A. Up-regulation in FOXM1 lowers MAT1A, but raises NF-κB, expression, and this is a feed-forward loop that enhances tumorigenesis.

Published
2020

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