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1. Influence of Rician Noise on Cardiac MR Image Segmentation Using Deep Learning

Author

Wu, Chien-Cheng, Hsu, Chao-Hsiung, Wang, Paul C., Tu, Tsang-Wei, Hsu, Yi-Yu, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Abraham, Ajith, editor, Bajaj, Anu, editor, Hanne, Thomas, editor, and Siarry, Patrick, editor

Published
2024
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3. Mesenchymal Stromal Cell Delivery Via Cardiopulmonary Bypass Provides Neuroprotection in a Juvenile Porcine Model

Author

Sarkislali, Kamil, Kobayashi, Kei, Sarić, Nemanja, Maeda, Takuya, Henmi, Soichiro, Somaa, Fahad A., Bansal, Ankush, Tu, Shao Ching, Leonetti, Camille, Hsu, Chao-Hsiung, Li, Jingang, Vyas, Pranav, Kawasawa, Yuka Imamura, Tu, Tsang-Wei, Wang, Paul C., Hanley, Patrick J., Hashimoto-Torii, Kazue, Frank, Joseph A., Jonas, Richard A., and Ishibashi, Nobuyuki

Published
2023
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5. Abstract 10858: Mesenchymal Stromal Cell Delivery via Cardiopulmonary Bypass Provides Neuroprotection in a Juvenile Porcine Surgical Model

Author

Kobayashi, Kei, Sarkislali, Kamil, Saric, Nemanja, Maeda, Takuya, Somaa, Fahad A, Bansal, Ankush, Tu, Shao Ching, Ayodeji, Mobolanle A, Leonetti, Camille, Hsu, Chao-hsiung, Li, Jingang, Vyas, Pranav, Imamura Kawasawa, Yuka, Tu, Tsang-Wei, Wang, Paul C, Hanley, Patrick J, Hashimoto-Torii, Kazue, frank, joseph A, Jonas, Richard, and Ishibashi, Nobuyuki

Published
2022
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7. BIOMARKERS FOR BIOCHEMICAL, PATHOPHYSIOLOGICAL, AND NEUROLOGICAL EFFECTS OF HIGH AMMONIA ON THE BRAIN

Author

Caldovic, Ljubica, primary, Li, Tina, additional, Sonaimuthu, Parthasarathy, additional, Smith, Nathan, additional, Liu, Judy, additional, Scafidi, Joseph, additional, Tu, Tsang-Wei, additional, Hsu, Chao-Hsiung, additional, Agaronyan, Artur, additional, Morizono, Hiroki, additional, Gropman, Andrea, additional, and Mew, Nicholas Ah., additional

Published
2023
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8. Classification of Activated Microglia by Convolutional Neural Networks

Author

Hsu, Chao-Hsiung, primary, Agaronyan, Artur, additional, Katherine, Raffensperger, additional, Kadden, Micah, additional, Ton, Hoai T., additional, Wu, Frank, additional, Lin, Yu-Shun, additional, Lee, Yih-Jing, additional, Wang, Paul C., additional, Shoykhet, Michael, additional, and Tu, Tsang-Wei, additional

Published
2022
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19. International Society for Therapeutic Ultrasound Conference 2016

Author

Fowlkes, Brian, Ghanouni, Pejman, Sanghvi, Narendra, Coussios, Constantin, Lyon, Paul C., Gray, Michael, Mannaris, Christophoros, Victor, Marie de Saint, Stride, Eleanor, Cleveland, Robin, Carlisle, Robert, Wu, Feng, Middleton, Mark, Gleeson, Fergus, Aubry, Jean-Franҫois, Pauly, Kim Butts, Moonen, Chrit, Vortman, Jacob, Sharabi, Shirley, Daniels, Dianne, Last, David, Guez, David, Levy, Yoav, Volovick, Alexander, Grinfeld, Javier, Rachmilevich, Itay, Amar, Talia, Zibly, Zion, Mardor, Yael, Harnof, Sagi, Plaksin, Michael, Weissler, Yoni, Shoham, Shy, Kimmel, Eitan, Naor, Omer, Farah, Nairouz, Paeng, Dong-Guk, Xu, Zhiyuan, Snell, John, Quigg, Anders H., Eames, Matthew, Jin, Changzhu, Everstine, Ashli C., Sheehan, Jason P., Lopes, Beatriz S., Kassell, Neal, Looi, Thomas, Khokhlova, Vera, Mougenot, Charles, Hynynen, Kullervo, Drake, James, Slayton, Michael, Amodei, Richard C., Compton, Keegan, McNelly, Ashley, Latt, Daniel, Kearney, John, Melodelima, David, Dupre, Aurelien, Chen, Yao, Perol, David, Vincenot, Jeremy, Chapelon, Jean-Yves, Rivoire, Michel, Guo, Wei, Ren, Guoxin, Shen, Guofeng, Neidrauer, Michael, Zubkov, Leonid, Weingarten, Michael S., Margolis, David J., Lewin, Peter A., McDannold, Nathan, Sutton, Jonathan, Vykhodtseva, Natalia, Livingstone, Margaret, Kobus, Thiele, Zhang, Yong-Zhi, Schwartz, Michael, Huang, Yuexi, Lipsman, Nir, Jain, Jennifer, Chapman, Martin, Sankar, Tejas, Lozano, Andres, Yeung, Robert, Damianou, Christakis, Papadopoulos, Nikolaos, Brokman, Omer, Zadicario, Eyal, Brenner, Ori, Castel, David, Wu, Shih-Ying, Grondin, Julien, Zheng, Wenlan, Heidmann, Marc, Karakatsani, Maria Eleni, Sánchez, Carlos J. Sierra, Ferrera, Vincent, Konofagou, Elisa E., Yiannakou, Marinos, Cho, HongSeok, Lee, Hwayoun, Han, Mun, Choi, Jong-Ryul, Lee, Taekwan, Ahn, Sanghyun, Chang, Yongmin, Park, Juyoung, Ellens, Nicholas, Partanen, Ari, Farahani, Keyvan, Airan, Raag, Carpentier, Alexandre, Canney, Michael, Vignot, Alexandre, Lafon, Cyril, Delattre, Jean-yves, Idbaih, Ahmed, Odéen, Henrik, Bolster, Bradley, Jeong, Eun Kee, Parker, Dennis L., Gaur, Pooja, Feng, Xue, Fielden, Samuel, Meyer, Craig, Werner, Beat, Grissom, William, Marx, Michael, Weber, Hans, Taviani, Valentina, Hargreaves, Brian, Tanaka, Jun, Kikuchi, Kentaro, Ishijima, Ayumu, Azuma, Takashi, Minamihata, Kosuke, Yamaguchi, Satoshi, Nagamune, Teruyuki, Sakuma, Ichiro, Takagi, Shu, Santin, Mathieu D., Marsac, Laurent, Maimbourg, Guillaume, Monfort, Morgane, Larrat, Benoit, François, Chantal, Lehéricy, Stéphane, Tanter, Mickael, Samiotaki, Gesthimani, Wang, Shutao, Acosta, Camilo, Feinberg, Eliza R., Kovacs, Zsofia I., Tu, Tsang-Wei, Papadakis, Georgios Z., Reid, William C., Hammoud, Dima A., Frank, Joseph A., Kovacs, Zsofia i., Kim, Saejeong, Jikaria, Neekita, Bresler, Michele, Qureshi, Farhan, Xia, Jingjing, Tsui, Po-Shiang, Liu, Hao-Li, Plata, Juan C., Sveinsson, Bragi, Salgaonkar, Vasant A., Adams, Matthew, Diederich, Chris, Ozhinsky, Eugene, Bucknor, Matthew D., Rieke, Viola, Mikhail, Andrew, Severance, Lauren, Negussie, Ayele H., Wood, Bradford, de Greef, Martijn, Schubert, Gerald, Ries, Mario, Poorman, Megan E., Dockery, Mary, Chaplin, Vandiver, Dudzinski, Stephanie O., Spears, Ryan, Caskey, Charles, Giorgio, Todd, Costa, Marcia M., Papaevangelou, Efthymia, Shah, Anant, Rivens, Ian, Box, Carol, Bamber, Jeff, ter Haar, Gail, Burks, Scott R., Nagle, Matthew, Nguyen, Ben, Milo, Blerta, Le, Nhan M., Song, Shaozhen, Zhou, Kanheng, Nabi, Ghulam, Huang, Zhihong, Ben-Ezra, Shmuel, Rosen, Shani, Mihcin, Senay, Strehlow, Jan, Karakitsios, Ioannis, Le, Nhan, Schwenke, Michael, Demedts, Daniel, Prentice, Paul, Haase, Sabrina, Preusser, Tobias, Melzer, Andreas, Mestas, Jean-Louis, Chettab, Kamel, Gomez, Gustavo Stadthagen, Dumontet, Charles, Werle, Bettina, Marquet, Fabrice, Bour, Pierre, Vaillant, Fanny, Amraoui, Sana, Dubois, Rémi, Ritter, Philippe, Haïssaguerre, Michel, Hocini, Mélèze, Bernus, Olivier, Quesson, Bruno, Livneh, Amit, Adam, Dan, Robin, Justine, Arnal, Bastien, Fink, Mathias, Pernot, Mathieu, Khokhlova, Tatiana D., Schade, George R., Wang, Yak-Nam, Kreider, Wayne, Simon, Julianna, Starr, Frank, Karzova, Maria, Maxwell, Adam, Bailey, Michael R., Lundt, Jonathan E., Allen, Steven P., Sukovich, Jonathan R., Hall, Timothy, Xu, Zhen, May, Philip, Lin, Daniel W., Constans, Charlotte, Deffieux, Thomas, Aubry, Jean-Francois, Park, Eun-Joo, Ahn, Yun Deok, Kang, Soo Yeon, Park, Dong-Hyuk, Lee, Jae Young, Vidal-Jove, J., Perich, E., Ruiz, A., Jaen, A., Eres, N., del Castillo, M. Alvarez, Myers, Rachel, Kwan, James, Coviello, Christian, Rowe, Cliff, Crake, Calum, Finn, Sean, Jackson, Edward, Pouliopoulos, Antonios, Li, Caiqin, Tinguely, Marc, Tang, Meng-Xing, Garbin, Valeria, Choi, James J., Folkes, Lisa, Stratford, Michael, Nwokeoha, Sandra, Li, Tong, Farr, Navid, D’Andrea, Samantha, Gravelle, Kayla, Chen, Hong, Lee, Donghoon, Hwang, Joo Ha, Tardoski, Sophie, Ngo, Jacqueline, Gineyts, Evelyne, Roux, Jean-Pau, Clézardin, Philippe, Conti, Allegra, Magnin, Rémi, Gerstenmayer, Matthieu, Lux, François, Tillement, Olivier, Mériaux, Sébastien, Penna, Stefania Della, Romani, Gian Luca, Dumont, Erik, Sun, Tao, Power, Chanikarn, Miller, Eric, Sapozhnikov, Oleg, Tsysar, Sergey, Yuldashev, Petr V., Svet, Victor, Li, Dongli, Pellegrino, Antonio, Petrinic, Nik, Siviour, Clive, Jerusalem, Antoine, Yuldashev, Peter V., Cunitz, Bryan W., Dunmire, Barbrina, Inserra, Claude, Guedra, Matthieu, Mauger, Cyril, Gilles, Bruno, Solovchuk, Maxim, Sheu, Tony W. H., Thiriet, Marc, Zhou, Yufeng, Neufeld, Esra, Baumgartner, Christian, Payne, Davnah, Kyriakou, Adamos, Kuster, Niels, Xiao, Xu, McLeod, Helen, Dillon, Christopher, Payne, Allison, Khokhova, Vera A., Sinilshchikov, Ilya, Andriyakhina, Yulia, Rybyanets, Andrey, Shvetsova, Natalia, Berkovich, Alex, Shvetsov, Igor, Shaw, Caroline J., Civale, John, Giussani, Dino, Lees, Christoph, Ozenne, Valery, Toupin, Solenn, Salgaonkar, Vasant, Kaye, Elena, Monette, Sebastien, Maybody, Majid, Srimathveeravalli, Govindarajan, Solomon, Stephen, Gulati, Amitabh, Bezzi, Mario, Jenne, Jürgen W., Lango, Thomas, Müller, Michael, Sat, Giora, Tanner, Christine, Zangos, Stephan, Günther, Matthias, Dinh, Au Hoang, Niaf, Emilie, Bratan, Flavie, Guillen, Nicolas, Souchon, Rémi, Lartizien, Carole, Crouzet, Sebastien, Rouviere, Olivier, Han, Yang, Payen, Thomas, Palermo, Carmine, Sastra, Steve, Olive, Kenneth, van Breugel, Johanna M., van den Bosch, Maurice A., Fellah, Benjamin, Le Bihan, Denis, Hernandez-Garcia, Luis, Cain, Charles A., Lyka, Erasmia, Elbes, Delphine, Li, Chunhui, Tamano, Satoshi, Jimbo, Hayato, Yoshizawa, Shin, Fujiwara, Keisuke, Itani, Kazunori, Umemura, Shin-ichiro, Stoianovici, Dan, Zaini, Zulfadhli, Takagi, Ryo, Zong, Shenyan, Watkins, Ron, Pascal-Tenorio, Aurea, Jones, Peter, Butts-Pauly, Kim, Bouley, Donna, Chen, Yazhu, Lin, Chung-Yin, Hsieh, Han-Yi, Wei, Kuo-Chen, Garnier, Camille, Renault, Gilles, Seifabadi, Reza, Wilson, Emmanuel, Eranki, Avinash, Kim, Peter, Lübke, Dennis, Huber, Peter, Georgii, Joachim, Dresky, Caroline V., Haller, Julian, Yarmolenko, Pavel, Sharma, Karun, Celik, Haydar, Li, Guofeng, Qiu, Weibao, Zheng, Hairong, Tsai, Meng-Yen, Chu, Po-Chun, Webb, Taylor, Vyas, Urvi, Walker, Matthew, Zhong, Jidan, Waspe, Adam C., Hodaie, Mojgan, Yang, Feng-Yi, Huang, Sin-Luo, Zur, Yuval, Assif, Benny, Aurup, Christian, Kamimura, Hermes, Carneiro, Antonio A., Rothlübbers, Sven, Schwaab, Julia, Houston, Graeme, Azhari, Haim, Weiss, Noam, Sosna, Jacob, Goldberg, S. Nahum, Barrere, Victor, Jang, Kee W., Lewis, Bobbi, Wang, Xiaotong, Suomi, Visa, Edwards, David, Larrabee, Zahary, Hananel, Arik, Rafaely, Boaz, Debbiny, Rasha Elaimy, Dekel, Carmel Zeltser, Assa, Michael, Menikou, George, Mouratidis, Petros, Pineda-Pardo, José A., de Pedro, Marta Del Álamo, Martinez, Raul, Hernandez, Frida, Casas, Silvia, Oliver, Carlos, Pastor, Patricia, Vela, Lidia, Obeso, Jose, Greillier, Paul, Zorgani, Ali, Catheline, Stefan, Solovov, Vyacheslav, Vozdvizhenskiy, Michael O., Orlov, Andrew E., Wu, Chueh-Hung, Sun, Ming-Kuan, Shih, Tiffany T., Chen, Wen-Shiang, Prieur, Fabrice, Pillon, Arnaud, Cartron, Valerie, Cebe, Patrick, Chansard, Nathalie, Lafond, Maxime, Seya, Pauline Muleki, Bera, Jean-Christophe, Boissenot, Tanguy, Fattal, Elias, Bordat, Alexandre, Chacun, Helene, Guetin, Claire, Tsapis, Nicolas, Maruyama, Kazuo, Unga, Johan, Suzuki, Ryo, Fant, Cécile, Rogez, Bernadette, Afadzi, Mercy, Myhre, Ola Finneng, Vea, Siri, Bjørkøy, Astrid, Yemane, Petros Tesfamichael, van Wamel, Annemieke, Berg, Sigrid, Hansen, Rune, Angelsen, Bjørn, and Davies, Catharina

Subjects
Meeting Abstracts
Published
2017

21. Comparison of in vivo and in situ detection of hippocampal metabolites in mouse brain using 1H‐MRS.

Author

Hsu, Chao‐Hsiung, Lin, Stephen, Ho, Ai‐Chen, Johnson, T. Derek, Wang, Paul C., Scafidi, Joseph, and Tu, Tsang‐Wei

Subjects
PROTON magnetic resonance spectroscopy, AMINOBUTYRIC acid, METABOLITES, BRAIN metabolism, HIPPOCAMPUS (Brain)
Abstract

The study of cerebral metabolites relies heavily on detection methods and sample preparation. Animal experiments in vivo require anesthetic agents that can alter brain metabolism, whereas ex vivo experiments demand appropriate fixation methods to preserve the tissue from rapid postmortem degradation. In this study, the metabolic profiles of mouse hippocampi using proton magnetic resonance spectroscopy (1H‐MRS) were compared in vivo and in situ with or without focused beam microwave irradiation (FBMI) fixation. Ten major brain metabolites, including lactate (Lac), N‐acetylaspartate (NAA), total choline (tCho), myo‐inositol (mIns), glutamine (Gln), glutamate (Glu), aminobutyric acid (GABA), glutathione (GSH), total creatine (tCr) and taurine (Tau), were analyzed using LCModel. After FBMI fixation, the concentrations of Lac, tCho and mIns were comparable with those obtained in vivo under isoflurane, whereas other metabolites were significantly lower. Except for a decrease in NAA and an increase in Tau, all the other metabolites remained stable over 41 hours in FBMI‐fixed brains. Without FBMI, the concentrations of mIns (before 2 hours), tCho and GABA were close to those measured in vivo. However, higher Lac (P <.01) and lower NAA, Gln, Glu, GSH, tCr and Tau were observed (P <.01). NAA, Gln, Glu, GSH, tCr and Tau exhibited good temporal stability for at least 20 hours in the unfixed brain, whereas a linear increase of tCho, mIns and GABA was observed. Possible mechanisms of postmortem degradation are discussed. Our results indicate that a proper fixation method is required for in situ detection depending on the targeted metabolites of specific interests in the brain. [ABSTRACT FROM AUTHOR]

Published
2021
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27. 5th International Symposium on Focused Ultrasound

Author

Zaaroor, Menashe, primary, Sinai, Alon, additional, Goldsher, Dorit, additional, Eran, Ayelet, additional, Nassar, Maria, additional, Schlesinger, Ilana, additional, Parker, Jonathon, additional, Ravikumar, Vinod, additional, Ghanouni, Pejman, additional, Stein, Sherman, additional, Halpern, Casey, additional, Krishna, Vibhor, additional, Hargrove, Amelia, additional, Agrawal, Punit, additional, Changizi, Barbara, additional, Bourekas, Eric, additional, Knopp, Michael, additional, Rezai, Ali, additional, Mead, Brian, additional, Kim, Namho, additional, Mastorakos, Panagiotis, additional, Suk, Jung Soo, additional, Miller, Wilson, additional, Klibanov, Alexander, additional, Hanes, Justin, additional, Price, Richard, additional, Wang, Shutao, additional, Olumolade, Oluyemi, additional, Kugelman, Tara, additional, Jackson-Lewis, Vernice, additional, Karakatsani, Maria Eleni, additional, Han, Yang, additional, Przedborski, Serge, additional, Konofagou, Elisa, additional, Hynynen, Kullervo, additional, Aubert, Isabelle, additional, Leinenga, Gerhard, additional, Nisbet, Rebecca, additional, Hatch, Robert, additional, Van der Jeugd, Anneke, additional, Evans, Harrison, additional, Götz, Jürgen, additional, Van der Jeugd, Ann, additional, Fishman, Paul, additional, Yarowsky, Paul, additional, Frenkel, Victor, additional, Wei-Bin, Shen, additional, Nguyen, Ben, additional, Sanchez, Carlos Sierra, additional, Acosta, Camilo, additional, Chen, Cherry, additional, Wu, Shih-Ying, additional, Aryal, Muna, additional, Papademetriou, Iason T., additional, Zhang, Yong-Zhi, additional, Power, Chanikarn, additional, McDannold, Nathan, additional, Porter, Tyrone, additional, Kovacs, Zsofia, additional, Kim, Saejeong, additional, Jikaria, Neekita, additional, Qureshi, Farhan, additional, Bresler, Michele, additional, Frank, Joseph, additional, Odéen, Henrik, additional, Chiou, George, additional, Snell, John, additional, Todd, Nick, additional, Madore, Bruno, additional, Parker, Dennis, additional, Pauly, Kim Butts, additional, Marx, Mike, additional, Jonathan, Sumeeth, additional, Grissom, William, additional, Arvanitis, Costas, additional, Clement, Gregory, additional, de Bever, Joshua, additional, Payne, Allison, additional, Christensen, Douglas, additional, Maimbourg, Guillaume, additional, Santin, Mathieu David, additional, Houdouin, Alexandre, additional, Lehericy, Stéphane, additional, Tanter, Mickael, additional, Aubry, Jean Francois, additional, Federau, Christian, additional, Werner, Beat, additional, Paeng, Dong-Guk, additional, Xu, Zhiyuan, additional, Quigg, Anders, additional, Eames, Matt, additional, Jin, Changzhu, additional, Everstine, Ashli, additional, Sheehan, Jason, additional, Lopes, M. Beatriz, additional, Kassell, Neal, additional, Drake, James, additional, Price, Karl, additional, Lustgarten, Lior, additional, Sin, Vivian, additional, Mougenot, Charles, additional, Donner, Elizabeth, additional, Tam, Emily, additional, Hodaie, Mojgan, additional, Waspe, Adam, additional, Looi, Thomas, additional, Pichardo, Samuel, additional, Lee, Wonhye, additional, Chung, Yong An, additional, Jung, Yujin, additional, Song, In-Uk, additional, Yoo, Seung-Schik, additional, Kim, Hyun-Chul, additional, Lee, Jong-Hwan, additional, Caskey, Charles, additional, Zinke, Wolf, additional, Cosman, Josh, additional, Shuman, Jillian, additional, Schall, Jeffrey, additional, Aurup, Christian, additional, Chen, Hong, additional, Kamimura, Hermes, additional, Carneiro, Antonio, additional, Sun, Tao, additional, Nazai, Navid, additional, Patz, Sam, additional, Livingstone, Margaret, additional, Mainprize, Todd, additional, Huang, Yuexi, additional, Alkins, Ryan, additional, Chapman, Martin, additional, Perry, James, additional, Lipsman, Nir, additional, Bethune, Allison, additional, Sahgal, Arjun, additional, Trudeau, Maureen, additional, Liu, Hao-Li, additional, Hsu, Po-Hung, additional, Wei, Kuo-Chen, additional, Sutton, Jonathan, additional, Alexander, Phillip, additional, Miller, Eric, additional, Kobus, Thiele, additional, Carpentier, Alexandre, additional, Canney, Michael, additional, Vignot, Alexandre, additional, Beccaria, Kevin, additional, Leclercq, Delphine, additional, Lafon, Cyril, additional, Chapelon, Jean Yves, additional, Hoang-Xuan, Khe, additional, Delattre, Jean-Yves, additional, Idbaih, Ahmed, additional, Moore, David, additional, Xu, Alexis, additional, Schmitt, Paul, additional, Foley, Jessica, additional, Sukovich, Jonathan, additional, Cain, Charles, additional, Pandey, Aditya, additional, Chaudhary, Neeraj, additional, Camelo-Piragua, Sandra, additional, Allen, Steven, additional, Cannata, Jon, additional, Teofilovic, Dejan, additional, Bertolina, Jim, additional, Hall, Timothy, additional, Xu, Zhen, additional, Grondin, Julien, additional, Ferrera, Vincent, additional, ter Haar, Gail, additional, Mouratidis, Petros, additional, Repasky, Elizabeth, additional, Timbie, Kelsie, additional, Badr, Lena, additional, Campbell, Benjamin, additional, McMichael, John, additional, Buckner, Andrew, additional, Prince, Jessica, additional, Stevens, Aaron, additional, Bullock, Timothy, additional, Skalina, Karin, additional, Guha, Chandan, additional, Orsi, Franco, additional, Bonomo, Guido, additional, Vigna, Paolo Della, additional, Mauri, Giovanni, additional, Varano, Gianluca, additional, Schade, George, additional, Wang, Yak-Nam, additional, Pillarisetty, Venu, additional, Hwang, Joo Ha, additional, Khokhlova, Vera, additional, Bailey, Michael, additional, Khokhlova, Tatiana, additional, Sinilshchikov, Ilya, additional, Yuldashev, Petr, additional, Andriyakhina, Yulia, additional, Kreider, Wayne, additional, Maxwell, Adam, additional, Sapozhnikov, Oleg, additional, Partanen, Ari, additional, Lundt, Jonathan, additional, Preusser, Tobias, additional, Haase, Sabrina, additional, Bezzi, Mario, additional, Jenne, Jürgen, additional, Langø, Thomas, additional, Midiri, Massimo, additional, Mueller, Michael, additional, Sat, Giora, additional, Tanner, Christine, additional, Zangos, Stephan, additional, Guenther, Matthias, additional, Melzer, Andreas, additional, Menciassi, Arianna, additional, Tognarelli, Selene, additional, Cafarelli, Andrea, additional, Diodato, Alessandro, additional, Ciuti, Gastone, additional, Rothluebbers, Sven, additional, Schwaab, Julia, additional, Strehlow, Jan, additional, Mihcin, Senay, additional, Tretbar, Steffen, additional, Payen, Thomas, additional, Palermo, Carmine, additional, Sastra, Steve, additional, Olive, Kenneth, additional, Adams, Matthew, additional, Salgaonkar, Vasant, additional, Scott, Serena, additional, Sommer, Graham, additional, Diederich, Chris, additional, Vidal-Jove, Joan, additional, Perich, Eloi, additional, Ruiz, Antonio, additional, Velat, Manuela, additional, Melodelima, David, additional, Dupre, Aurelien, additional, Vincenot, Jeremy, additional, Yao, Chen, additional, Perol, David, additional, Rivoire, Michel, additional, Tucci, Samantha, additional, Mahakian, Lisa, additional, Fite, Brett, additional, Ingham, Elizabeth, additional, Tam, Sarah, additional, Hwang, Chang-il, additional, Tuveson, David, additional, Ferrara, Katherine, additional, Scionti, Stephen, additional, Chen, Lili, additional, Cvetkovic, Dusica, additional, Chen, Xiaoming, additional, Gupta, Roohi, additional, Wang, Bin, additional, Ma, Charlie, additional, Bader, Kenneth, additional, Haworth, Kevin, additional, Holland, Christy, additional, Sanghvi, Narendra, additional, Carlson, Roy, additional, Chen, Wohsing, additional, Chaussy, Christian, additional, Thueroff, Stefan, additional, Cesana, Claudio, additional, Bellorofonte, Carlo, additional, Wang, Qingguo, additional, Wang, Han, additional, Wang, Shengping, additional, Zhang, Junhai, additional, Bazzocchi, Alberto, additional, Napoli, Alessandro, additional, Staruch, Robert, additional, Bing, Chenchen, additional, Shaikh, Sumbul, additional, Nofiele, Joris, additional, Szczepanski, Debra, additional, Staruch, Michelle Wodzak, additional, Williams, Noelle, additional, Laetsch, Theodore, additional, Chopra, Rajiv, additional, Rosenberg, Jarrett, additional, Bitton, Rachelle, additional, LeBlang, Suzanne, additional, Meyer, Joshua, additional, Hurwitz, Mark, additional, Yarmolenko, Pavel, additional, Celik, Haydar, additional, Eranki, Avinash, additional, Beskin, Viktoriya, additional, Santos, Domiciano, additional, Patel, Janish, additional, Oetgen, Matthew, additional, Kim, AeRang, additional, Kim, Peter, additional, Sharma, Karun, additional, Chisholm, Alexander, additional, Aleman, Dionne, additional, Scipione, Roberto, additional, Temple, Michael, additional, Amaral, Joao Guilherme, additional, Endre, Ruby, additional, Lamberti-Pasculli, Maria, additional, de Ruiter, Joost, additional, Campbell, Fiona, additional, Stimec, Jennifer, additional, Gupta, Samit, additional, Singh, Manoj, additional, Hopyan, Sevan, additional, Czarnota, Gregory, additional, Brenin, David, additional, Rochman, Carrie, additional, Kovatcheva, Roussanka, additional, Vlahov, Jordan, additional, Zaletel, Katja, additional, Stoinov, Julian, additional, Bucknor, Matthew, additional, Rieke, Viola, additional, Shim, Jenny, additional, Koral, Korgun, additional, Lang, Brian, additional, Wong, Carlos, additional, Lam, Heather, additional, Shinkov, Alexander, additional, Hu, Jim, additional, Zhang, Xi, additional, Macoskey, Jonathan, additional, Ives, Kimberly, additional, Owens, Gabe, additional, Gurm, Hitinder, additional, Shi, Jiaqi, additional, Pizzuto, Matthew, additional, Dillon, Christopher, additional, Christofferson, Ivy, additional, Hilas, Elaine, additional, Shea, Jill, additional, Greillier, Paul, additional, Ankou, Bénédicte, additional, Bessière, Francis, additional, Zorgani, Ali, additional, Pioche, Mathieu, additional, Kwiecinski, Wojciech, additional, Magat, Julie, additional, Melot-Dusseau, Sandrine, additional, Lacoste, Romain, additional, Quesson, Bruno, additional, Pernot, Mathieu, additional, Catheline, Stefan, additional, Chevalier, Philippe, additional, Marquet, Fabrice, additional, Bour, Pierre, additional, Vaillant, Fanny, additional, Amraoui, Sana, additional, Dubois, Rémi, additional, Ritter, Philippe, additional, Haïssaguerre, Michel, additional, Hocini, Mélèze, additional, Bernus, Olivier, additional, Tebebi, Pamela, additional, Burks, Scott, additional, Milo, Blerta, additional, Gertner, Michael, additional, Zhang, Jimin, additional, Wong, Andrew, additional, Liu, Yu, additional, Kheirolomoom, Azadeh, additional, Seo, Jai, additional, Watson, Katherine, additional, Zhang, Hua, additional, Foiret, Josquin, additional, Borowsky, Alexander, additional, Xu, Doudou, additional, Thanou, Maya, additional, Centelles, Miguell, additional, Wright, Mike, additional, Amrahli, Maral, additional, So, Po-Wah, additional, Gedroyc, Wladyslaw, additional, Kneepkens, Esther, additional, Heijman, Edwin, additional, Keupp, Jochen, additional, Weiss, Steffen, additional, Nicolay, Klaas, additional, Grüll, Holger, additional, Nagle, Matthew, additional, Nikolaeva, Anastasia V., additional, Terzi, Marina E., additional, Tsysar, Sergey A., additional, Cunitz, Bryan, additional, Mourad, Pierre, additional, Downs, Matthew, additional, Yang, Georgiana, additional, Wang, Qi, additional, Chen, Johnny, additional, Farry, Justin, additional, Dixon, Adam, additional, Du, Zhongmin, additional, Dhanaliwala, Ali, additional, Hossack, John, additional, Ranjan, Ashish, additional, Maples, Danny, additional, Wardlow, Rachel, additional, Malayer, Jerry, additional, Ramachandran, Akhilesh, additional, Namba, Hirofumi, additional, Kawasaki, Motohiro, additional, Izumi, Masashi, additional, Kiyasu, Katsuhito, additional, Takemasa, Ryuichi, additional, Ikeuchi, Masahiko, additional, Ushida, Takahiro, additional, Crake, Calum, additional, Kothapalli, Satya V. V. N., additional, Leighton, Wan, additional, Wang, Zhaorui, additional, Gach, H. Michael, additional, Straube, William, additional, Altman, Michael, additional, Kim, Young-sun, additional, Lim, Hyo Keun, additional, Rhim, Hyunchul, additional, van Breugel, Johanna, additional, Braat, Manon, additional, Moonen, Chrit, additional, van den Bosch, Maurice, additional, Ries, Mario, additional, Marrocchio, Cristina, additional, Dababou, Susan, additional, Lee, Jae Young, additional, Chung, Hyun Hoon, additional, Kang, Soo Yeon, additional, Kang, Kook Jin, additional, Son, Keon Ho, additional, Zhang, Dandan, additional, Plata, Juan, additional, Jones, Peter, additional, Pascal-Tenorio, Aurea, additional, Bouley, Donna, additional, Bond, Aaron, additional, Dallapiazza, Robert, additional, Huss, Diane, additional, Warren, Amy, additional, Sperling, Scott, additional, Gwinn, Ryder, additional, Shah, Binit, additional, Elias, W. Jeff, additional, Curley, Colleen, additional, Zhang, Ying, additional, Negron, Karina, additional, Abounader, Roger, additional, Samiotaki, Gesthimani, additional, Tu, Tsang-Wei, additional, Papadakis, Georgios, additional, Hammoud, Dima, additional, Silvestrini, Matthew, additional, Wolfram, Frank, additional, Güllmar, Daniel, additional, Reichenbach, Juergen, additional, Hofmann, Denis, additional, Böttcher, Joachim, additional, Schubert, Harald, additional, Lesser, Thomas G., additional, Almquist, Scott, additional, Camarena, Francisco, additional, Jiménez-Gambín, Sergio, additional, Jiménez, Noé, additional, Chang, Jin Woo, additional, Chaplin, Vandiver, additional, Griesenauer, Rebekah, additional, Miga, Michael, additional, Ellens, Nicholas, additional, Airan, Raag, additional, Quinones-Hinojosa, Alfredo, additional, Farahani, Keyvan, additional, Feng, Xue, additional, Fielden, Samuel, additional, Zhao, Li, additional, Wintermark, Max, additional, Meyer, Craig, additional, Guo, Sijia, additional, Lu, Xin, additional, Zhuo, Jiachen, additional, Xu, Su, additional, Gullapalli, Rao, additional, Gandhi, Dheeraj, additional, Brokman, Omer, additional, Baek, Hongchae, additional, Kim, Hyungmin, additional, Leung, Steven, additional, Webb, Taylor, additional, Vykhodtseva, Natalia, additional, Nguyen, Thai-Son, additional, Park, Chang Kyu, additional, Park, Sang Man, additional, Jung, Na Young, additional, Kim, Min Soo, additional, Chang, Won Seok, additional, Jung, Hyun Ho, additional, Plaksin, Michael, additional, Weissler, Yoni, additional, Shoham, Shy, additional, Kimmel, Eitan, additional, Rosnitskiy, Pavel B., additional, Krupa, Steve, additional, Hazan, Eilon, additional, Naor, Omer, additional, Levy, Yoav, additional, Maimon, Noam, additional, Brosh, Inbar, additional, Kahn, Itamar, additional, Cahill, Jessica, additional, Colas, Elodie Constanciel, additional, Wydra, Adrian, additional, Maev, Roman, additional, Aly, Amirah, additional, Sesenoglu-Laird, Ozge, additional, Padegimas, Linas, additional, Cooper, Mark, additional, Waszczak, Barbara, additional, Tehrani, Seruz, additional, Slingluff, Craig, additional, Larner, James, additional, Andarawewa, Kumari, additional, Ozhinsky, Eugene, additional, Shah, Rutwik, additional, Krug, Roland, additional, Deckers, Roel, additional, Linn, Sabine, additional, Suelmann, Britt, additional, Witkamp, Arjen, additional, Vaessen, Paul, additional, van Diest, Paul, additional, Bartels, Lambertus W., additional, Bos, Clemens, additional, Borys, Nicolas, additional, Storm, Gert, additional, Van der Wall, Elsken, additional, Farr, Navid, additional, Alnazeer, Moez, additional, Katti, Prateek, additional, Wood, Bradford, additional, Farrer, Alexis, additional, Ferrer, Cyril, additional, de Senneville, Baudouin Denis, additional, van Stralen, Marijn, additional, Liu, Jingfei, additional, Leach, J. Kent, additional, Zidowitz, Stephan, additional, Lee, Hsin-Lun, additional, Hsu, Fang-Chi, additional, Kuo, Chia-Chun, additional, Jeng, Shiu-Chen, additional, Chen, Tung-Ho, additional, Yang, Nai-Yi, additional, Chiou, Jeng-Fong, additional, Kao, Yi-tzu, additional, Pan, Chia-Hsin, additional, Wu, Jing-Fu, additional, Tsai, Yi-Chieh, additional, Johnson, Sara, additional, Li, Dawei, additional, He, Ye, additional, Karakitsios, Ioannis, additional, Schwenke, Michael, additional, Demedts, Daniel, additional, Xiao, Xu, additional, Cavin, Ian, additional, Minalga, Emilee, additional, Merrill, Robb, additional, Hadley, Rock, additional, Ramaekers, Pascal, additional, de Greef, Martijn, additional, Shahriari, Kian, additional, Parvizi, Mohammad Hossein, additional, Asadnia, Kiana, additional, Chamanara, Marzieh, additional, Kamrava, Seyed Kamran, additional, Chabok, Hamid Reza, additional, Stein, Ruben, additional, Muller, Sébastien, additional, Tan, Jeremy, additional, Zachiu, Cornel, additional, Erasmus, Hans-Peter, additional, Van Arsdell, Glen, additional, Benson, Lee, additional, Jang, Kee W., additional, Angstadt, Mary, additional, Lewis, Bobbi, additional, McLean, Hailey, additional, Hoogenboom, Martijn, additional, Eikelenboom, Dylan, additional, den Brok, Martijn, additional, Wesseling, Pieter, additional, Heerschap, Arend, additional, Fütterer, Jurgen, additional, Adema, Gosse, additional, Wang, Kevin, additional, Zhong, Pei, additional, Joy, Joyce, additional, McLeod, Helen, additional, Kim, Harry, additional, Lewis, Matthew, additional, Ozilgen, Arda, additional, Zahos, Peter, additional, Coughlin, Dezba, additional, Tang, Xinyan, additional, Lotz, Jeff, additional, Jedruszczuk, Kathleen, additional, Gulati, Amitabh, additional, Solomon, Stephen, additional, Kaye, Elena, additional, Mugler, John, additional, Barbato, Gaetano, additional, Scoarughi, Gian Luca, additional, Corso, Cristiano, additional, Gorgone, Alessandro, additional, Migliore, Ilaria Giuseppina, additional, Larrabee, Zachary, additional, Hananel, Arik, additional, Aubry, Jean-Francois, additional, Negussie, Ayele, additional, Wilson, Emmanuel, additional, Seifabadi, Reza, additional, Moon, Hyungwon, additional, Kang, Jeeun, additional, Sim, Changbeom, additional, Chang, Jin Ho, additional, Kim, Hyuncheol, additional, Lee, Hak Jong, additional, Sasaki, Noboru, additional, Takiguchi, Mitsuyoshi, additional, Sebeke, Lukas, additional, Luo, Xi, additional, de Jager, Bram, additional, Heemels, Maurice, additional, Abraham, Christopher, additional, Curiel, Laura, additional, Berriet, Rémi, additional, Janát-Amsbury, Margit, additional, Corea, Joseph, additional, Ye, Patrick Peiyong, additional, Arias, Ana Clauda, additional, Lustig, Micheal, additional, and Svedin, Bryant, additional

Published
2016
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28. Diffusion tensor imaging detects treatment effects of FTY720 in experimental autoimmune encephalomyelitis mice

Author

Wang, Xiaojie, Brieland, Joan K., Kim, Joong H., Chen, Ying-Jr, O’Neal, Janet, O’Neil, Shawn R., Tu, Tsang-Wei, Trinkaus, Kathryn, and Song, Sheng-Kwei

Subjects
Encephalomyelitis, Autoimmune, Experimental, Fingolimod Hydrochloride, Myelin Basic Protein, Article, Spine, Mice, Inbred C57BL, Mice, Diffusion Tensor Imaging, nervous system, Propylene Glycols, Sphingosine, hemic and lymphatic diseases, Disease Progression, Animals, Anisotropy, Female
Abstract

Fingolimod (FTY720) is an orally available sphingosine-1-phosphate (S1P) receptor modulator reducing relapse frequency in patients with relapsing-remitting multiple sclerosis (RRMS). In addition to immunosuppression, neuronal protection by FTY720 has also been suggested, but remains controversial. Axial and radial diffusivities derived from in vivo diffusion tensor imaging (DTI) were employed as noninvasive biomarkers of axonal injury and demyelination to assess axonal protection by FTY720 in experimental autoimmune encephalomyelitis (EAE) mice. EAE was induced through active immunization of C57BL/6 mice using myelin oligodendrocyte glycoprotein peptide 35-55 (MOG(35-55)). We evaluated both the prophylactic and therapeutic treatment effect of FTY720 at doses of 3 and 10 mg/kg on EAE mice by daily clinical scoring and end-point in vivo DTI. Prophylactic administration of FTY720 suppressed the disease onset and prevented axon and myelin damage when compared with EAE mice without treatment. Therapeutic treatment by FTY720 did not prevent EAE onset, but reduced disease severity, improving axial and radial diffusivity towards the control values without statistical significance. Consistent with previous findings, in vivo DTI-derived axial and radial diffusivity correlated with clinical scores in EAE mice. The results support the use of in vivo DTI as an effective outcome measure for preclinical drug development.

Published
2013

36. International Society for Therapeutic Ultrasound Conference 2016: Tel Aviv, Israel. 14-18 March, 2016

Author

Fowlkes, Brian, Ghanouni, Pejman, Sanghvi, Narendra, Coussios, Constantin, Lyon, Paul C., Gray, Michael, Mannaris, Christophoros, Victor, Marie de Saint, Stride, Eleanor, Cleveland, Robin, Carlisle, Robert, Wu, Feng, Middleton, Mark, Gleeson, Fergus, Aubry, Jean-Franҫois, Pauly, Kim Butts, Moonen, Chrit, Vortman, Jacob, Sharabi, Shirley, Daniels, Dianne, Last, David, Guez, David, Levy, Yoav, Volovick, Alexander, Grinfeld, Javier, Rachmilevich, Itay, Amar, Talia, Zibly, Zion, Mardor, Yael, Harnof, Sagi, Plaksin, Michael, Weissler, Yoni, Shoham, Shy, Kimmel, Eitan, Naor, Omer, Farah, Nairouz, Paeng, Dong-Guk, Xu, Zhiyuan, Snell, John, Quigg, Anders H., Eames, Matthew, Jin, Changzhu, Everstine, Ashli C., Sheehan, Jason P., Lopes, Beatriz S., Kassell, Neal, Looi, Thomas, Khokhlova, Vera, Mougenot, Charles, Hynynen, Kullervo, Drake, James, Slayton, Michael, Amodei, Richard C., Compton, Keegan, McNelly, Ashley, Latt, Daniel, Kearney, John, Melodelima, David, Dupre, Aurelien, Chen, Yao, Perol, David, Vincenot, Jeremy, Chapelon, Jean-Yves, Rivoire, Michel, Guo, Wei, Ren, Guoxin, Shen, Guofeng, Neidrauer, Michael, Zubkov, Leonid, Weingarten, Michael S., Margolis, David J., Lewin, Peter A., McDannold, Nathan, Sutton, Jonathan, Vykhodtseva, Natalia, Livingstone, Margaret, Kobus, Thiele, Zhang, Yong-Zhi, Schwartz, Michael, Huang, Yuexi, Lipsman, Nir, Jain, Jennifer, Chapman, Martin, Sankar, Tejas, Lozano, Andres, Yeung, Robert, Damianou, Christakis, Papadopoulos, Nikolaos, Brokman, Omer, Zadicario, Eyal, Brenner, Ori, Castel, David, Wu, Shih-Ying, Grondin, Julien, Zheng, Wenlan, Heidmann, Marc, Karakatsani, Maria Eleni, Sánchez, Carlos J. Sierra, Ferrera, Vincent, Konofagou, Elisa E., Yiannakou, Marinos, Cho, HongSeok, Lee, Hwayoun, Han, Mun, Choi, Jong-Ryul, Lee, Taekwan, Ahn, Sanghyun, Chang, Yongmin, Park, Juyoung, Ellens, Nicholas, Partanen, Ari, Farahani, Keyvan, Airan, Raag, Carpentier, Alexandre, Canney, Michael, Vignot, Alexandre, Lafon, Cyril, Delattre, Jean-yves, Idbaih, Ahmed, Odéen, Henrik, Bolster, Bradley, Jeong, Eun Kee, Parker, Dennis L., Gaur, Pooja, Feng, Xue, Fielden, Samuel, Meyer, Craig, Werner, Beat, Grissom, William, Marx, Michael, Weber, Hans, Taviani, Valentina, Hargreaves, Brian, Tanaka, Jun, Kikuchi, Kentaro, Ishijima, Ayumu, Azuma, Takashi, Minamihata, Kosuke, Yamaguchi, Satoshi, Nagamune, Teruyuki, Sakuma, Ichiro, Takagi, Shu, Santin, Mathieu D., Marsac, Laurent, Maimbourg, Guillaume, Monfort, Morgane, Larrat, Benoit, François, Chantal, Lehéricy, Stéphane, Tanter, Mickael, Samiotaki, Gesthimani, Wang, Shutao, Acosta, Camilo, Feinberg, Eliza R., Kovacs, Zsofia I., Tu, Tsang-Wei, Papadakis, Georgios Z., Reid, William C., Hammoud, Dima A., Frank, Joseph A., Kovacs, Zsofia i., Kim, Saejeong, Jikaria, Neekita, Bresler, Michele, Qureshi, Farhan, Xia, Jingjing, Tsui, Po-Shiang, Liu, Hao-Li, Plata, Juan C., Sveinsson, Bragi, Salgaonkar, Vasant A., Adams, Matthew, Diederich, Chris, Ozhinsky, Eugene, Bucknor, Matthew D., Rieke, Viola, Mikhail, Andrew, Severance, Lauren, Negussie, Ayele H., Wood, Bradford, de Greef, Martijn, Schubert, Gerald, Ries, Mario, Poorman, Megan E., Dockery, Mary, Chaplin, Vandiver, Dudzinski, Stephanie O., Spears, Ryan, Caskey, Charles, Giorgio, Todd, Costa, Marcia M., Papaevangelou, Efthymia, Shah, Anant, Rivens, Ian, Box, Carol, Bamber, Jeff, ter Haar, Gail, Burks, Scott R., Nagle, Matthew, Nguyen, Ben, Milo, Blerta, Le, Nhan M., Song, Shaozhen, Zhou, Kanheng, Nabi, Ghulam, Huang, Zhihong, Ben-Ezra, Shmuel, Rosen, Shani, Mihcin, Senay, Strehlow, Jan, Karakitsios, Ioannis, Le, Nhan, Schwenke, Michael, Demedts, Daniel, Prentice, Paul, Haase, Sabrina, Preusser, Tobias, Melzer, Andreas, Mestas, Jean-Louis, Chettab, Kamel, Gomez, Gustavo Stadthagen, Dumontet, Charles, Werle, Bettina, Marquet, Fabrice, Bour, Pierre, Vaillant, Fanny, Amraoui, Sana, Dubois, Rémi, Ritter, Philippe, Haïssaguerre, Michel, Hocini, Mélèze, Bernus, Olivier, Quesson, Bruno, Livneh, Amit, Adam, Dan, Robin, Justine, Arnal, Bastien, Fink, Mathias, Pernot, Mathieu, Khokhlova, Tatiana D., Schade, George R., Wang, Yak-Nam, Kreider, Wayne, Simon, Julianna, Starr, Frank, Karzova, Maria, Maxwell, Adam, Bailey, Michael R., Lundt, Jonathan E., Allen, Steven P., Sukovich, Jonathan R., Hall, Timothy, Xu, Zhen, May, Philip, Lin, Daniel W., Constans, Charlotte, Deffieux, Thomas, Aubry, Jean-Francois, Park, Eun-Joo, Ahn, Yun Deok, Kang, Soo Yeon, Park, Dong-Hyuk, Lee, Jae Young, Vidal-Jove, J., Perich, E., Ruiz, A., Jaen, A., Eres, N., del Castillo, M. Alvarez, Myers, Rachel, Kwan, James, Coviello, Christian, Rowe, Cliff, Crake, Calum, Finn, Sean, Jackson, Edward, Pouliopoulos, Antonios, Li, Caiqin, Tinguely, Marc, Tang, Meng-Xing, Garbin, Valeria, Choi, James J., Folkes, Lisa, Stratford, Michael, Nwokeoha, Sandra, Li, Tong, Farr, Navid, D’Andrea, Samantha, Gravelle, Kayla, Chen, Hong, Lee, Donghoon, Hwang, Joo Ha, Tardoski, Sophie, Ngo, Jacqueline, Gineyts, Evelyne, Roux, Jean-Pau, Clézardin, Philippe, Conti, Allegra, Magnin, Rémi, Gerstenmayer, Matthieu, Lux, François, Tillement, Olivier, Mériaux, Sébastien, Penna, Stefania Della, Romani, Gian Luca, Dumont, Erik, Sun, Tao, Power, Chanikarn, Miller, Eric, Sapozhnikov, Oleg, Tsysar, Sergey, Yuldashev, Petr V., Svet, Victor, Li, Dongli, Pellegrino, Antonio, Petrinic, Nik, Siviour, Clive, Jerusalem, Antoine, Yuldashev, Peter V., Cunitz, Bryan W., Dunmire, Barbrina, Inserra, Claude, Guedra, Matthieu, Mauger, Cyril, Gilles, Bruno, Solovchuk, Maxim, Sheu, Tony W. H., Thiriet, Marc, Zhou, Yufeng, Neufeld, Esra, Baumgartner, Christian, Payne, Davnah, Kyriakou, Adamos, Kuster, Niels, Xiao, Xu, McLeod, Helen, Dillon, Christopher, Payne, Allison, Khokhova, Vera A., Sinilshchikov, Ilya, Andriyakhina, Yulia, Rybyanets, Andrey, Shvetsova, Natalia, Berkovich, Alex, Shvetsov, Igor, Shaw, Caroline J., Civale, John, Giussani, Dino, Lees, Christoph, Ozenne, Valery, Toupin, Solenn, Salgaonkar, Vasant, Kaye, Elena, Monette, Sebastien, Maybody, Majid, Srimathveeravalli, Govindarajan, Solomon, Stephen, Gulati, Amitabh, Bezzi, Mario, Jenne, Jürgen W., Lango, Thomas, Müller, Michael, Sat, Giora, Tanner, Christine, Zangos, Stephan, Günther, Matthias, Dinh, Au Hoang, Niaf, Emilie, Bratan, Flavie, Guillen, Nicolas, Souchon, Rémi, Lartizien, Carole, Crouzet, Sebastien, Rouviere, Olivier, Han, Yang, Payen, Thomas, Palermo, Carmine, Sastra, Steve, Olive, Kenneth, van Breugel, Johanna M., van den Bosch, Maurice A., Fellah, Benjamin, Le Bihan, Denis, Hernandez-Garcia, Luis, Cain, Charles A., Lyka, Erasmia, Elbes, Delphine, Li, Chunhui, Tamano, Satoshi, Jimbo, Hayato, Yoshizawa, Shin, Fujiwara, Keisuke, Itani, Kazunori, Umemura, Shin-ichiro, Stoianovici, Dan, Zaini, Zulfadhli, Takagi, Ryo, Zong, Shenyan, Watkins, Ron, Pascal-Tenorio, Aurea, Jones, Peter, Butts-Pauly, Kim, Bouley, Donna, Chen, Yazhu, Lin, Chung-Yin, Hsieh, Han-Yi, Wei, Kuo-Chen, Garnier, Camille, Renault, Gilles, Seifabadi, Reza, Wilson, Emmanuel, Eranki, Avinash, Kim, Peter, Lübke, Dennis, Huber, Peter, Georgii, Joachim, Dresky, Caroline V., Haller, Julian, Yarmolenko, Pavel, Sharma, Karun, Celik, Haydar, Li, Guofeng, Qiu, Weibao, Zheng, Hairong, Tsai, Meng-Yen, Chu, Po-Chun, Webb, Taylor, Vyas, Urvi, Walker, Matthew, Zhong, Jidan, Waspe, Adam C., Hodaie, Mojgan, Yang, Feng-Yi, Huang, Sin-Luo, Zur, Yuval, Assif, Benny, Aurup, Christian, Kamimura, Hermes, Carneiro, Antonio A., Rothlübbers, Sven, Schwaab, Julia, Houston, Graeme, Azhari, Haim, Weiss, Noam, Sosna, Jacob, Goldberg, S. Nahum, Barrere, Victor, Jang, Kee W., Lewis, Bobbi, Wang, Xiaotong, Suomi, Visa, Edwards, David, Larrabee, Zahary, Hananel, Arik, Rafaely, Boaz, Debbiny, Rasha Elaimy, Dekel, Carmel Zeltser, Assa, Michael, Menikou, George, Mouratidis, Petros, Pineda-Pardo, José A., de Pedro, Marta Del Álamo, Martinez, Raul, Hernandez, Frida, Casas, Silvia, Oliver, Carlos, Pastor, Patricia, Vela, Lidia, Obeso, Jose, Greillier, Paul, Zorgani, Ali, Catheline, Stefan, Solovov, Vyacheslav, Vozdvizhenskiy, Michael O., Orlov, Andrew E., Wu, Chueh-Hung, Sun, Ming-Kuan, Shih, Tiffany T., Chen, Wen-Shiang, Prieur, Fabrice, Pillon, Arnaud, Cartron, Valerie, Cebe, Patrick, Chansard, Nathalie, Lafond, Maxime, Seya, Pauline Muleki, Bera, Jean-Christophe, Boissenot, Tanguy, Fattal, Elias, Bordat, Alexandre, Chacun, Helene, Guetin, Claire, Tsapis, Nicolas, Maruyama, Kazuo, Unga, Johan, Suzuki, Ryo, Fant, Cécile, Rogez, Bernadette, Afadzi, Mercy, Myhre, Ola Finneng, Vea, Siri, Bjørkøy, Astrid, Yemane, Petros Tesfamichael, van Wamel, Annemieke, Berg, Sigrid, Hansen, Rune, Angelsen, Bjørn, and Davies, Catharina

Published
2017
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38. Classification of Activated Microglia by Convolutional Neural Networks.

Author

Hsu CH, Agaronyan A, Katherine R, Kadden M, Ton HT, Wu F, Lin YS, Lee YJ, Wang PC, Shoykhet M, and Tu TW

Abstract

Microglia are the resident macrophages in the central nervous system. Brain injuries, such as traumatic brain injury, hypoxia, and stroke, can induce inflammatory responses accompanying microglial activation. The morphology of microglia is notably diverse and is one of the prominent manifestations during activation. In this study, we proposed to detect the activated microglia in immunohistochemistry images by convolutional neural networks (CNN). 2D Iba1 images (40 μ m) were acquired from a control and a cardiac arrest treated Sprague-Dawley rat brain by a scanning microscope using a 20X objective. The training data were a collection of 54,333 single-cell images obtained from the cortex and midbrain areas, and curated by experienced neuroscientists. Results were compared between CNNs with different architectures, including Resnet18, Resnet50, Resnet101, and support vector machine (SVM) classifiers. The highest model performance was found by Resnet18, trained after 120 epochs with a classification accuracy of 95.5%. The findings indicate a potential application for using CNN in quantitative analysis of microglial morphology over regional difference in a large brain section.

Published
2022
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40. Comparison of in vivo and in situ detection of hippocampal metabolites in mouse brain using 1 H-MRS.

Author

Hsu CH, Lin S, Ho AC, Johnson TD, Wang PC, Scafidi J, and Tu TW

Subjects
Animals, Body Water, Female, Hippocampus metabolism, Lipids analysis, Male, Mice, Mice, Inbred C57BL, Microwaves, Postmortem Changes, Random Allocation, Tissue Fixation methods, Hippocampus diagnostic imaging, Magnetic Resonance Spectroscopy methods, Neuroimaging methods, Proton Magnetic Resonance Spectroscopy methods
Abstract

The study of cerebral metabolites relies heavily on detection methods and sample preparation. Animal experiments in vivo require anesthetic agents that can alter brain metabolism, whereas ex vivo experiments demand appropriate fixation methods to preserve the tissue from rapid postmortem degradation. In this study, the metabolic profiles of mouse hippocampi using proton magnetic resonance spectroscopy ( 1 H-MRS) were compared in vivo and in situ with or without focused beam microwave irradiation (FBMI) fixation. Ten major brain metabolites, including lactate (Lac), N-acetylaspartate (NAA), total choline (tCho), myo-inositol (mIns), glutamine (Gln), glutamate (Glu), aminobutyric acid (GABA), glutathione (GSH), total creatine (tCr) and taurine (Tau), were analyzed using LCModel. After FBMI fixation, the concentrations of Lac, tCho and mIns were comparable with those obtained in vivo under isoflurane, whereas other metabolites were significantly lower. Except for a decrease in NAA and an increase in Tau, all the other metabolites remained stable over 41 hours in FBMI-fixed brains. Without FBMI, the concentrations of mIns (before 2 hours), tCho and GABA were close to those measured in vivo. However, higher Lac (P < .01) and lower NAA, Gln, Glu, GSH, tCr and Tau were observed (P < .01). NAA, Gln, Glu, GSH, tCr and Tau exhibited good temporal stability for at least 20 hours in the unfixed brain, whereas a linear increase of tCho, mIns and GABA was observed. Possible mechanisms of postmortem degradation are discussed. Our results indicate that a proper fixation method is required for in situ detection depending on the targeted metabolites of specific interests in the brain., (© 2020 John Wiley & Sons Ltd.)

Published
2021
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