231 results on '"Tu, Zheng-Chao"'
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2. Eugenilones A−N: sesquiterpenoids from the fruits of Eugenia uniflora
3. 1-Methyl-3-((4-(quinolin-4-yloxy)phenyl)amino)-1H-pyrazole-4-carboxamide derivatives as new rearranged during Transfection (RET) kinase inhibitors capable of suppressing resistant mutants in solvent-front regions
4. Neolignans and Norlignans from Insect Medicine Polyphaga plancyi and Their Biological Activities
5. Design, synthesis, and Structure–Activity Relationships (SAR) of 3-vinylindazole derivatives as new selective tropomyosin receptor kinases (Trk) inhibitors
6. Quinolone antibiotic derivatives as new selective Axl kinase inhibitors
7. Structure-based drug design: Synthesis and biological evaluation of quinazolin-4-amine derivatives as selective Aurora A kinase inhibitors
8. COX-2 and JAK3 inhibitory meroterpenoids from the mushroom Ganoderma theaecolum
9. Synthesis and biological evaluation of aurora kinases inhibitors based on N-trisubstituted pyrimidine scaffold
10. 2-Oxo-3, 4-dihydropyrimido[4, 5-d]pyrimidinyl derivatives as new irreversible pan fibroblast growth factor receptor (FGFR) inhibitors
11. Design, synthesis and cytotoxic activities of novel 2,5-diketopiperazine derivatives
12. Discovery of AXL Degraders with Improved Potencies in Triple-Negative Breast Cancer (TNBC) Cells
13. Miscellaneous meroterpenoids from Ganoderma applanatum
14. Site selective synthesis of cytotoxic 1,3,6-trisubstituted 3,6-diunsaturated (3Z,6Z)-2,5-diketopiperazines via a one-pot multicomponent method
15. Discovery of 2-(2-aminopyrimidin-5-yl)-4-morpholino-N-(pyridin-3-yl)quinazolin-7-amines as novel PI3K/mTOR inhibitors and anticancer agents
16. Dopamine derivatives from the insect Polyrhachis dives as inhibitors of ROCK1/2 and stimulators of neural stem cell proliferation
17. Design, synthesis and bioevaluation of N-trisubstituted pyrimidine derivatives as potent aurora A kinase inhibitors
18. Aspergone, a new chromanone derivative from fungus Aspergillus sp. SCSIO41002 derived of mangrove soil sample
19. Design, Synthesis, and Biological Evaluation of 2-Formyl Tetrahydronaphthyridine Urea Derivatives as New Selective Covalently Reversible FGFR4 Inhibitors
20. Discovery of potent dipeptidyl peptidase IV inhibitors through pharmacophore hybridization and hit-to-lead optimization
21. Mechanisms Underlying Campylobacter fetus Pathogenesis in Humans: Surface-Layer Protein Variation in Relapsing Infections
22. 2-Amino-2,3-dihydro-1H-indene-5-carboxamide-Based Discoidin Domain Receptor 1 (DDR1) Inhibitors: Design, Synthesis, and in Vivo Antipancreatic Cancer Efficacy
23. Investigation of Covalent Warheads in the Design of 2-Aminopyrimidine-based FGFR4 Inhibitors
24. Ansamycin derivatives from the marine-derived Streptomyces sp. SCSGAA 0027 and their cytotoxic and antiviral activities
25. Neolignans and Norlignans from Insect Medicine Polyphaga plancyi and Their Biological Activities
26. Sulfur and nitrogen-containing compounds from the whole bodies of Blaps japanensis
27. Polymorphism in Mitochondrial DNA (mtDNA) of Yak (Bos grunniens)
28. NOTE: Blood Protein Polymorphism in B. frontalis, B. grunniens, B. taurus, and B. indicus
29. Campylobacter fetus uses multiple loci for DNA inversion within the 5' conserved regions of sap homologs
30. Design and Optimization of 3′-(Imidazo[1,2-a]pyrazin-3-yl)-[1,1′-biphenyl]-3-carboxamides as Selective DDR1 Inhibitors
31. Genetic Diversity and Divergence in Chinese Yak (Bos grunniens) Populations Inferred from Blood Protein Electrophoresis
32. Structure and genotypic plasticity of the Campylobacter fetus sap locus
33. Blood Protein Polymorphism in B. frontalis, B. grunniens, B. taurus, and B. indicus
34. (±) Gancochlearols A and B: cytotoxic and COX-2 inhibitory meroterpenoids from Ganoderma cochlear
35. Design, Synthesis, and Structure–Activity Relationships of 1,2,3-Triazole Benzenesulfonamides as New Selective Leucine-Zipper and Sterile-α Motif Kinase (ZAK) Inhibitors
36. Nucleoside and N-acetyldopamine derivatives from the insect Aspongopus chinensis
37. Meroterpenoid dimers from Ganoderma cochlear and their cytotoxic and COX-2 inhibitory activities
38. (±) Gancochlearols A and B: cytotoxic and COX-2 inhibitory meroterpenoids from Ganoderma cochlear.
39. Neolignans and Norlignans from Insect Medicine Polyphaga plancyiand Their Biological Activities
- Abstract
Abstract: Ten neolignans or norlignans (1–10) including eight new compounds were isolated from the whole bodies of Polyphaga plancyiBolivar. Their structures were identified by spectroscopic data. Compounds 3, 4, 8, and 9are racemates indicated by chiral HPLC analysis. Chiral separation followed by ECD calculations allowed to clarify the absolute configurations of all the antipodes. All the new compounds were evaluated for their biological properties toward extracellular matrix in rat renal proximal tubular cells, human cancer cells (K562, A549, and Huh7), EV71, ROCK2, JAK3, DDR1, and coagulation. Graphic Abstract:
40. (±) Cochlearoids N–P: three pairs of phenolic meroterpenoids from the fungus Ganoderma cochlear and their bioactivities
41. Design, Synthesis, and Structure–Activity Relationship Study of 2-Oxo-3,4-dihydropyrimido[4,5-d]pyrimidines as New Colony Stimulating Factor 1 Receptor (CSF1R) Kinase Inhibitors
42. Meroterpenoids from the fruiting bodies of Ganoderma theaecolum
43. Cochlearoids L and M: Two New Meroterpenoids from the Fungus Ganoderma cochlear
44. Two New Compounds from Medicinal Insect Blaps japanensis and Their Biological Evaluation
45. Quinone/hydroquinone meroterpenoids with antitubercular and cytotoxic activities produced by the sponge-derived fungus Gliomastix sp. ZSDS1-F7
46. Compounds from the insect Blaps japanensis with COX-1 and COX-2 inhibitory activities
47. 2-Oxo-3, 4-dihydropyrimido[4, 5- d ]pyrimidinyl derivatives as new irreversible pan fibroblast growth factor receptor (FGFR) inhibitors
48. Vaccinols J–S, ten new salicyloid derivatives from the marine mangrove-derived endophytic fungus Pestalotiopsis vaccinii
49. Phenolic derivatives from Blaps japanensis and their biological evaluation
50. Structure Based Design of N-(3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)benzenesulfonamides as Selective Leucine-Zipper and Sterile-α Motif Kinase (ZAK) Inhibitors
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