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Comprehensive Summary: We report herein an unprecedented N‐heterocyclic carbene‐catalyzed formal [3 + 3] annulation of ynals with N‐Ts indolin‐3‐ones under the oxidation condition affording the functionalized pyrano[3,2‐b]indol‐2‐ones. The alkynyl acylazoliums via the combination of a carbene with ynals in the presence of oxidate proved to be the important intermediates for the success of this transformation. This method features a broad substrate scope and mild conditions, including axially chiral skeletons with suitable substitutions. [ABSTRACT FROM AUTHOR]

In this paper, a new type of structured electron beam is introduced, which is the electron Airy tornado wave (eATW) with the characteristics of abrupt auto‐focusing and rotation property in free space. It is also found that the eATWs propagate periodically in a magnetic field, and their patterns of intensity distributions show the time‐like axial symmetry about a half‐period point in a period of time. Furthermore, the influence of the magnetic field's magnitude and direction on eATWs with different parameters has also been discussed. [ABSTRACT FROM AUTHOR]

This paper analytically and numerically proposes the propagation dynamics of the symmetric Pearcey Gaussian vortex beam (SPGVB) in the uniformly moving parabolic potential. The optical vortex located in the initial plane produces a vortex channel in the presence of the uniformly moving parabolic potential, called the vortex trajectory. The vortex trajectory can be manipulated dynamically by configuring different combinations of the parameters, and the optical intensity and the focal position can also be affected. Moreover, the spatial dynamic vortex trajectory is derived analytically, and the 2D on‐axis and off‐axis vortex scenarios are also presented. Our work expands the methods of the vortex trajectory manipulation and may broaden more practical potential applications in the particle manipulation. [ABSTRACT FROM AUTHOR]

Comprehensive Summary: We report herein an unprecedented N‐heterocyclic carbene‐catalyzed formal [3 + 3] annulation of ynals with N‐Ts indolin‐3‐ones under the oxidation condition affording the functionalized pyrano[3,2‐b]indol‐2‐ones. The alkynyl acylazoliums via the combination of a carbene with ynals in the presence of oxidate proved to be the important intermediates for the success of this transformation. This method features a broad substrate scope and mild conditions, including axially chiral skeletons with suitable substitutions. [ABSTRACT FROM AUTHOR]

Objective: To study the expression of VEGF in sinonasal squamous cell carcinoma and its correlations with microvessel density (MVD), microlymphatic vessel density (MLVD)., Method: The expression of VEGF, MVD and MLVD in 41 cases of sinonasal squamous cell carcinoma were detected by immunohistochemical technique., Result: In the sinonasal squamous cell carcinoma, the positive rate of VEGF was 82.9% (34/41). The over expression of VEGF was related with tumor invasion, histological grading and lymphatic metastasis (P < 0.05). The MVD of cases with positive VEGF expression was significantly higher than those without VEGF expression (P < 0.05), but was not statistical difference in MLVD (P > 0.05)., Conclusion: VEGF may participate in the metastasis of sinonasal squamous cell carcinoma through promoting vascularization in the tumors, but not promoting MLVD.

Objective: To study the distribution and expression of STAT6 and to examine the suggested roles of STAT6 in the pathogenesis of eosinophil infiltration in nasal polyps and to evaluate the role of STAT6 in the pathogenesis of nasal polyps., Method: All selected cases met the enrollment criteria. Thirty samples of nasal polyps were obtained from patients undergoing nasal polypectomy, and 10 samples of inferior turbinate tissues were from patients undergoing nasal septal reconstruction. STAT6 in nasal polyp tissues from 30 nasal polyposis patients and 10 samples of inferior turbinate tissues were detected with immunohistochemistry (SP) method. SPSS13.0 system was used to perform the statistical analysis., Result: The positive expression of STAT6 was significantly higher in epithelium of nasal polyps than that of the control. The number of eosinophils was significantly higher in epithelium of nasal polyps than that of the control. The difference between these two groups was statistically significant (P<0.05). STAT6 positive cell were localized on epithelium, gland cells and on inflammatory cell of nasal polyps. STAT6 expression was positively correlated with the recruitment of eosinophils in nasal polyps., Conclusion: The high expression of STAT6 protein and the suggested roles of STAT6 in the recruitment of eosinophils in nasal polyps may contribute to the initiation and progression of nasal polyps.