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1. Evolution of invasive pneumococcal disease by serotype 3 in adults: a Spanish three-decade retrospective study

Author

Calvo-Silveria, Sara, González-Díaz, Aida, Grau, Inmaculada, Marimón, José María, Cercenado, Emilia, Quesada, M Dolores, Casabella, Antonio, Larrosa, Nieves, Yuste, José, Berbel, Dàmaris, Alonso, Marta, Tubau, Fe, Belman, Sophie, Cadenas-Jiménez, Irene, Martín-Galiano, Antonio J., Domínguez, M Ángeles, Martí, Sara, Liñares, Josefina, Pallarés, Román, Càmara, Jordi, and Ardanuy, Carmen

Published
2024
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2. Attributable mortality of infections caused by carbapenem-resistant Enterobacterales: results from a prospective, multinational case-control-control matched cohorts study (EURECA)

Author

Serna, Almudena de la, Monteau, Sophie, Palomo, Virginia, Soriano, Elena, Gutierrez, David, Moreno, Elisa, Sojo-Dorado, Jesus, Morales, Isabel, Maldonado, Natalia, Santis, Lucia Valiente de, Ciezar, Antonio Plata, Ruiz Mesa, Juan Diego, Diaz, Beatriz Sobrino, Gomez, Ignacio Marquez, Camacho, Ines Perez, Cano, Angela, Frutos-Adame, Azahara, Guzman-Puche, Julia, Gracia-Ahufinger, Irene, Perez-Nadales, Elena, Torre-Gimenez, Julian, Pyrpasopoulou, Athina, Iosifidis, Elias, Chorafa, Elsa, Radovanovic, Ivana, Petrovic, Sladjana, Cvetkovi, Slavica, Melentijevic, Srdjan-Sanja, Bicmen, Can, Senol, Gunes, Tubau, Fe, Camara, Jordi, Daniel Gumucio, Victor, Bassoulis, Dimitris, Deliolanis, John, Pitiriga, Vassiliki Ch., Triarides, Nikolaos, Argiti, Efstathia, Legakis, Nikolaos J., Margarita, Kyriakidou, Gijón-Cordero, Desirée, Ruiz-Garbajosa, Patricia, Rossolini, Gian Maria, Nica, Maria, Talapan, Daniela, Medić, Deana, Prijić, Sanja Maričić, Caballero, Mireia Cantero, Ramírez, Lina M Parra, Bilgin, Hüseyin, Dalekos, George N., Stefos, Aggelos, Spyridis, Nikolaos, Michos, Athanasios, De Rosa, Francesco Giuseppe, Cavallo, Rossana, Petrosillo, Nicola, Dicaro, Antonio, Landini, Maria Paola, degli Atti, Marta Luisa Ciofi, Masanovic, Mileva, Matkovic, Dusan, Tsiodras, Sotirios, Blasi, Francesco, pasquale, Marta Di, Viscoli, Claudio, Vata, Andrei, Dorneanu, Olivia, Kapisyzi, Perlat, Vince, Adriana, Tsigou, Evdoxia, Maltezos, Efstratios, Komnos, Apostolos, Gogos, Charalampos, Franzetti, Fabio, Antonelli, Massimo, Lupse, Mihaela, Corneci, Dan, Tomescu, Dana, Georgescu, Anca, Bukarica, Ljiljana, Mitrović, Goran, Krstić, Nataša Lukić, Kurti, Arsim, Reuter, Sandra, Díaz-Pollán, Beatriz, Sabater, Julia Origüen, Muñoz, Patricia, Azap, Alpay, ancak, Banu, Sahin, Arife, Akalin, Halis, Paniagua-García, María, Bravo-Ferrer, Jose M., Pérez-Galera, Salvador, Kostyanev, Tomislav, de Kraker, Marlieke E.A., Feifel, Jan, Palacios-Baena, Zaira R., Schotsman, Joost, Cantón, Rafael, Daikos, George L., Carevic, Biljana, Dragovac, Gorana, Tan, Lionel K., Raka, Lul, Hristea, Adriana, Viale, Pierluigi, Akova, Murat, Cano, Ángela, Reguera, Jose María, Bartoloni, Alessandro, Florescu, Simin-Aysel, Benea, Serban, Asensio, Ángel, Korten, Volkan, Grundmann, Hajo, Goossens, Herman, Bonten, Marc J., Gutiérrez-Gutiérrez, Belén, and Rodríguez-Baño, Jesús

Published
2024
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3. Efficacy of extended infusion of β-lactam antibiotics for the treatment of febrile neutropenia in haematologic patients (BEATLE): a randomized, multicentre, open-label, superiority clinical trial

Author

Laporte-Amargos, Julia, Carmona-Torre, Francisco, Huguet, Maria, Puerta-Alcalde, Pedro, Rigo-Bonnin, Raul, Ulldemolins, Marta, Arnan, Montserrat, del Pozo, Jose Luis, Torrent, Anna, Garcia-Vidal, Carolina, Pallarès, Natàlia, Tebé, Cristian, Muñoz, Carme, Tubau, Fe, Padullés, Ariadna, Sureda, Ana-Maria, Carratalà, Jordi, and Gudiol, Carlota

Published
2024
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4. Pseudomonas aeruginosa antibiotic susceptibility profiles, genomic epidemiology and resistance mechanisms: a nation-wide five-year time lapse analysis

Author

Galán-Sánchez, Fátima, Gracia-Ahufinger, Irene, Martínez-Martínez, Luis, Liébana-Martos, Carmen, Roldán, Carolina, Sánchez-Calvo, Juan Manuel, Clavijo, Encarnación, Mora-Navas, Laura, Aznar, Javier, Lepe, José Antonio, Rodríguez-Villodres, Ángel, Recacha, Esther, Casas-Círia, Francisco Javier, Martínez-Rubio, Carmen, Sempere-Alcocer, Marco Antonio, Martín-Hita, Lina, Seral, Cristina, López-Calleja, Ana Isabel, Aspiroz, Carmen, Monforte, Marisa, Iglesia-Martínez, Pedro de la, Jimenez-Guerra, Gemma, Riera-Pérez, Elena, Collado, Carmen, Gallegos, Carmen, Mulet, Xavier, Fernández-Muñoz, Almudena, Sastre-Femenía, Miquel Àngel, Gomis-Font, María Antonia, Zamorano, Laura, Oliver, Antonio, Siller-Ruiz, María, Calvo, Jorge, Quesada, Dolores, Wang, Jun Hao, Pitart, Cristina, Marco, Francesc, Prim, Nuria, Horcajada, Juan Pablo, Padilla, Eduardo, Del Barrio-Tofiño, Ester, Viñado-Pérez, Belen, Larrosa, Nieves, Tubau, Fe, Capilla, Silvia, Casabella, Antonio, Pérez-Moreno, Mar Olga, Padilla, Emma, Ballestero, Mónica, Rivera, Alba, Navarro, Ferrán, Gómez-Bertomeu, Fréderic, Pardo-Granell, Sergio, Picó-Plana, Ester, Guerrero, Dolores, Sarvisé-Buil, Carolina, Belles-Belles, Alba, Fernández-Esgueva, Marta, Ortega-Lafont, María del Pilar, García, Inmaculada, Arenal-Andrés, Noelia, Hernando-Real, Susana, Ibáñez, Rosario, Martínez, Jesús, Becerra, Federico, Aldea-Mansilla, Carmen, Alaoui-Sosse, Asmaa, González, José Carlos, Guzman-Puche, Julia, Blázquez-Andrada, Miguel Ángel, Martínez-Ramírez, Nora Mariela, Beteta, Alicia, Gomila-Sard, Bárbara, Almaraz, Salvador Giner, Garduño, Eugenio, Juiz-González, Pedro Miguel, Arca-Suárez, Jorge, Alba, Javier, Alonso, Pilar, Rodríguez, Ana Isabel, Paz-Vidal, María Isabel, García-Campello, Marta, Camacho, Pablo, Pallarés, María de los Ángeles, Pérez del Molino, María Luisa, Coira, Amparo, Barbeito, Gema, Rincón, Anniris, Vasallo-Vidal, Francisco José, Alonso-Acero, Laura, Iglesias-Llorente, Laura, Bordes-Benites, Ana, Florén-Zabala, Laura, Azcona, José Manuel, Alonso, Carla Andrea, Sáenz, Yolanda, Lamata-Subero, Marta, Molina, David, González-Torralba, Ana, Villa, Jennifer, Viedma, Esther, Cercenado, Emilia, Alarcón, Teresa, Vargas, Paula, Díez, María, Cantón, Rafael, Ruiz, Patricia, Sánchez-Romero, María Isabel, Pérez-García, Felipe, Yagüe-Guirao, Genoveva, Oteiza, Amaia Concepción, Leiva, José, Portillo, María Eugenia, Canut-Blasco, Andrés, Vidal, Matxalen, Alonso, Iker, Zuriarrain, Maider, Barrios-Andrés, José Luis, Sastre-Femenia, Miquel Àngel, Taltavull, Biel, López-Causapé, Carla, and Oteo-Iglesias, Jesús

Published
2023
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5. Risk factors for infections caused by carbapenem-resistant Enterobacterales: an international matched case-control-control study (EURECA)

Author

de la Serna, Almudena, Monteau, Sophie, Palomo, Virginia, Soriano, Elena, Gutierrez, David, Moreno, Elisa, Palacios, Zaira, Morales, Isabel, Maldonado, Natalia, Ciezar, Antonio Plata, Ruiz Mesa, Juan Diego, Diaz, Beatriz Sobrino, Gomez, Ignacio Marquez, Camacho, Ines Perez, Frutos-Adame, Azahara, Guzman-Puche, Julia, Gracia-Ahufinger, Irene, Perez-Nadales, Elena, Torre-Gimenez, Julian, Pyrpasopoulou, Athina, Iosifidis, Elias, Chorafa, Elsa, Radovanovic, Ivana, Petrovic, Sladjana, Cvetkovi, Slavica, Melentijevic, Srdjan-Sanja, Bicmen, Can, Senol, Gunes, Tubau, Fe, Camara, Jordi, Gumucio, Victor Daniel, Bassoulis, Dimitris, Deliolanis, John, Pitiriga, Vassiliki Ch., Triarides, Nikolaos, Argiti, Efstathia, Legakis, Nikolaos J., Margarita, Kyriakidou, Gijón-Cordero, Desirée, Ruiz-Garbajosa, Patricia, Bartoloni, Alessandro, Rossolini, Gian Maria, Florescu, Simin-Aysel, Nica, Maria, Benea, Serban, Talapan, Daniela, Medić, Deana, Prijić, Sanja Maričić, Caballero, Mireia Cantero, Parra Ramírez, Lina M., Korten, Volkan, Bilgin, Hüseyin, Dalekos, George N., Stefos, Aggelos, Spyridis, Nikolaos, Michos, Athanasios, De Rosa, Francesco Giuseppe, Cavallo, Rossana, Petrosillo, Nicola, Dicaro, Antonio, Landini, Maria Paola, Ciofi degli Atti, Marta Luisa, Masanovic, Mileva, Matkovic, Dusan, Tsiodras, Sotirios, Blasi, Francesco, Di pasquale, Marta, Viscoli, Claudio, Vata, Andrei, Dorneanu, Olivia, Kapisyzi, Perlat, Vince, Adriana, Tsigou, Evdoxia, Maltezos, Efstratios, Komnos, Apostolos, Gogos, Charalampos, Franzetti, Fabio, Antonelli, Massimo, Lupse, Mihaela, Corneci, Dan, Tomescu, Dana, Georgescu, Anca, Bukarica, Ljiljana, Mitrović, Goran, Krstić, Nataša Lukić, Kurti, Arsim, Díaz-Pollán, Beatriz, Sabater, Julia Origüen, Muñoz, Patricia, Azap, Alpay, Sancak, Banu, Sahin, Arife, Akalin, Halis, Pérez-Galera, Salvador, Bravo-Ferrer, Jose M., Paniagua, María, Kostyanev, Tomislav, de Kraker, Marlieke E.A., Feifel, Jan, Sojo-Dorado, Jesús, Schotsman, Joost, Cantón, Rafael, Daikos, George L., Carevic, Biljana, Dragovac, Gorana, Tan, Lionel K., Raka, Lul, Hristea, Adriana, Viale, Pierluigi, Akova, Murat, Reguera, Jose María, Valiente de Santis, Lucía, Torre-Cisneros, Julián, Cano, Ángela, Roilides, Emmanuel, Radulovic, Lili, Kirakli, Cenk, Shaw, Evelyn, Falagas, Matthew E., Pintado, Vicente, Goossens, Herman, Bonten, Marc J., Gutiérrez-Gutiérrez, Belén, and Rodriguez-Baño, Jesús

Published
2023
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6. Antimicrobial use and aetiology of bloodstream infections in critically ill patients during early stages of SARS-CoV-2 pandemic

Author

Torrecillas, Miriam, Gumucio, Victor Daniel, Padullés, Ariadna, Tubau, Fe, Marco, Daniel, Shaw, Evelyn, Fernández-Huerta, Miguel, Maisterra, Krystel, Grau, Inmaculada, Petito, Melanie Maria, Berbel, Dàmaris, Puig-Asensio, Mireia, Pérez, Xosé Luis, Domínguez, Ma Ángeles, Sabater, Joan, Ardanuy, Carmen, and Càmara, Jordi

Published
2022
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7. A 30-year perspective of low-dose dexamethasone, a single dose of mannitol and antiseizures prophylaxis on the prognosis of pneumococcal meningitis.

Author

Cabellos, Carmen, Guillem, Lluïsa, Pelegrin, Ivan, Tubau, Fe, Ardanuy, Carmen, Gudiol, F., Ariza, J., and Viladrich, Pedro F.

Subjects
PNEUMOCOCCAL meningitis, MANNITOL, DEXAMETHASONE, PHENYTOIN, PROGNOSIS
Abstract

Objectives: This study details the accumulated experience of more than 31 years using a low-dose systematic dexamethasone protocol with mannitol and antiseizure prophylaxis for the treatment of suspected pneumococcal meningitis. Methods: Data have been prospectively collected for the period1977–2018. From 1987, patients with suspected pneumococcal meningitis received 12 mg dexamethasone followed by 4 mg/6 h for 48 h, started before or with the first antibiotic dose. They also received (1) a single intravenous dose of 0.5–1 g/Kg mannitol, and (2) antiseizure prophylaxis with phenytoin. Results: In total, 363 episodes of pneumococcal meningitis were recorded. Of these, 242 were treated with the dexamethasone protocol after 1987 and 121 were treated without the protocol. Overall mortality was 11.6% (28/242) among patients treated with dexamethasone and 35% (43/121) among those treated without dexamethasone (p = 0.000). Early mortality was significantly lower at 5.8% (14/242) with dexamethasone and 24% (29/121) without dexamethasone (p = 0.000). Finally, neurological mortality was significantly lower at 7.4% (18/242) with dexamethasone and 23% (28/121) without dexamethasone (p = 0.000). Conclusions: A low dose of dexamethasone along with a single dose of mannitol and antiseizures prophylaxis might be useful for reducing both overall and early mortality in pneumococcal meningitis in adult patients. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Molecular characterization of macrolide resistance in Haemophilus influenzae and Haemophilus parainfluenzae strains (2018–21).

Author

Cadenas-Jiménez, Irene, Saiz-Escobedo, Lucía, Carrera-Salinas, Anna, Camprubí-Márquez, Xenia, Calvo-Silveria, Sara, Camps-Massa, Paula, Berbel, Dàmaris, Tubau, Fe, Santos, Salud, Domínguez, M Angeles, González-Díaz, Aida, Ardanuy, Carmen, and Martí, Sara

Subjects
HAEMOPHILUS influenzae, WHOLE genome sequencing, MICROBIAL sensitivity tests, RIBOSOMAL RNA, DRUG resistance in microorganisms
Abstract

Objectives This study aimed to explore the prevalence of macrolide resistance and the underlying resistance mechanisms in Haemophilus influenzae (n  = 2556) and Haemophilus parainfluenzae (n  = 510) collected between 2018 and 2021 from Bellvitge University Hospital, Spain. Methods Antimicrobial susceptibility was tested by microdilution. Whole-genome sequencing was performed using Illumina MiSeq and Oxford Nanopore technologies, and sequences were examined for macrolide resistance determinants and mobile genetic structures. Results Macrolide resistance was detected in 67 H. influenzae (2.6%) and 52 (10.2%) H. parainfluenzae strains and associated with resistance to other antimicrobials (co-trimoxazole, chloramphenicol, tetracycline). Differences in macrolide resistance existed between the two species. Acquired resistance genes were more prevalent in H. parainfluenzae (35/52; 67.3%) than in H. influenzae (12/67; 17.9%). Gene mutations and amino acid substitutions were more common in H. influenzae (57/67; 85%) than in H. parainfluenzae (16/52; 30.8%). Substitutions in L22 and in 23S rRNA were only detected in H. influenzae (34.3% and 29.0%, respectively), while substitutions in L4 and AcrAB/AcrR were observed in both species. The MEGA element was identified in 35 (67.3%) H. parainfluenzae strains, five located in an integrative and conjugative element (ICE); by contrast, 11 (16.4%) H. influenzae strains contained the MEGA element (all in an ICE). A new ICE HpaHUB8 was described in H. parainfluenzae. Conclusions Macrolide resistance was higher in H. parainfluenzae than in H. influenzae , with differences in the underlying mechanisms. H. parainfluenzae exhibits co-resistance to other antimicrobials, often leading to an extensively drug-resistant phenotype. This highlights the importance of conducting antimicrobial resistance surveillance. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Predicting Pseudomonas aeruginosa susceptibility phenotypes from whole genome sequence resistome analysis

Author

Martínez-Martínez, Luis, Bou, Germán, Zamorano, Laura, Sánchez-Diener, Irina, Galán, Fátima, Gracia, Irene, Rodríguez, Manuel Antonio, Martín, Lina, Sánchez, Juan Manuel, Viñuela, Laura, García, M<ce:sup loc='post">a</ce:sup> Victoria, Lepe, José Antonio, Aznar, Javier, López-Hernández, Inma, Seral, Cristina, Castillo-García, Francisco Javier, López-Calleja, Ana Isabel, Aspiroz, Carmen, Iglesia, Pedro de la, Ramón, Susana, Riera, Elena, Pérez, María Cruz, Gallegos, Carmen, Calvo, Jorge, Quesada, María Dolores, Pitart, Cristina, Marco, Francesc, Hoyos, Yannick, Horcajada, Juan Pablo, Larrosa, Nieves, González, Juan José, Tubau, Fe, Capilla, Silvia, Pérez-Moreno, Mar Olga, Centelles, M<ce:sup loc='post">a</ce:sup> José, Padilla, Emma, Rivera, Alba, Mirelis, Beatriz, Rodríguez-Tarazona, Raquel Elisa, Arenal-Andrés, Noelia, Ortega, María del Pilar, Megías, Gregoria, García, Inmaculada, Colmenarejo, Cristina, González, José Carlos, Martínez, Nora Mariela, Gomila, Bárbara, Giner, Salvador, Tormo, Nuria, Garduño, Eugenio, Agulla, José Andrés, Seoane, Alejandro, Pita, Julia, Vidal, Isabel Paz, Guzmán, David Mauricio, García, Marta, Pérez del Molino, María Luisa, Barbeito, Gema, Artiles, Fernando, Azcona-Gutiérrez, José Manuel, Sáenz, Yolanda, Oteo, José Antonio, González, Ana, Villa, Jennifer, Chaves, Fernando, Cercenado, Emilia, Alarcón, Teresa, Zurita, Nelly Daniela, Gijón, Desiré, Merino, Irene, Morosini, María Isabel, Cantón, Rafael, Sánchez, María Isabel, Moreno, Laura, Yagüe, Genoveva, Leiva, José, Barrios, José Luis, Canut, Andrés, Oteo, Jesús, Cortes-Lara, Sara, Barrio-Tofiño, Ester del, López-Causapé, Carla, and Oliver, Antonio

Published
2021
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11. A multicentre analysis of Nocardia pneumonia in Spain: 2010–2016

Author

Ercibengoa, Maria, Càmara, Jordi, Tubau, Fe, García-Somoza, Dolores, Galar, Alicia, Martín-Rabadán, Pablo, Marin, Mercedes, Mateu, Lourdes, García-Olivé, Ignasi, Prat, Cristina, Cilloniz, Catia, Torres, Antonio, Pedro-Botet, Maria-Luisa, Ardanuy, Carmen, Muñoz, Patricia, and Marimón, Jose María

Published
2020
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12. Attributable mortality of infections caused by carbapenem-resistant Enterobacterales: results from a prospective, multinational case-control-control matched cohorts study (EURECA)

Author

Paniagua-García, María, primary, Bravo-Ferrer, Jose M., additional, Pérez-Galera, Salvador, additional, Kostyanev, Tomislav, additional, de Kraker, Marlieke E.A., additional, Feifel, Jan, additional, Palacios-Baena, Zaira R., additional, Schotsman, Joost, additional, Cantón, Rafael, additional, Daikos, George L., additional, Carevic, Biljana, additional, Dragovac, Gorana, additional, Tan, Lionel K., additional, Raka, Lul, additional, Hristea, Adriana, additional, Viale, Pierluigi, additional, Akova, Murat, additional, Cano, Ángela, additional, Reguera, Jose María, additional, Bartoloni, Alessandro, additional, Florescu, Simin-Aysel, additional, Benea, Serban, additional, Bukarica, Ljiljana, additional, Asensio, Ángel, additional, Korten, Volkan, additional, Grundmann, Hajo, additional, Goossens, Herman, additional, Bonten, Marc J., additional, Gutiérrez-Gutiérrez, Belén, additional, Rodríguez-Baño, Jesús, additional, Serna, Almudena de la, additional, Monteau, Sophie, additional, Palomo, Virginia, additional, Soriano, Elena, additional, Gutierrez, David, additional, Moreno, Elisa, additional, Sojo-Dorado, Jesus, additional, Morales, Isabel, additional, Maldonado, Natalia, additional, Santis, Lucia Valiente de, additional, Ciezar, Antonio Plata, additional, Ruiz Mesa, Juan Diego, additional, Diaz, Beatriz Sobrino, additional, Gomez, Ignacio Marquez, additional, Camacho, Ines Perez, additional, Cano, Angela, additional, Frutos-Adame, Azahara, additional, Guzman-Puche, Julia, additional, Gracia-Ahufinger, Irene, additional, Perez-Nadales, Elena, additional, Torre-Gimenez, Julian, additional, Pyrpasopoulou, Athina, additional, Iosifidis, Elias, additional, Chorafa, Elsa, additional, Radovanovic, Ivana, additional, Petrovic, Sladjana, additional, Cvetkovi, Slavica, additional, Melentijevic, Srdjan-Sanja, additional, Bicmen, Can, additional, Senol, Gunes, additional, Tubau, Fe, additional, Camara, Jordi, additional, Daniel Gumucio, Victor, additional, Bassoulis, Dimitris, additional, Deliolanis, John, additional, Pitiriga, Vassiliki Ch., additional, Triarides, Nikolaos, additional, Argiti, Efstathia, additional, Legakis, Nikolaos J., additional, Margarita, Kyriakidou, additional, Gijón-Cordero, Desirée, additional, Ruiz-Garbajosa, Patricia, additional, Rossolini, Gian Maria, additional, Nica, Maria, additional, Talapan, Daniela, additional, Medić, Deana, additional, Prijić, Sanja Maričić, additional, Caballero, Mireia Cantero, additional, Ramírez, Lina M Parra, additional, Bilgin, Hüseyin, additional, Dalekos, George N., additional, Stefos, Aggelos, additional, Spyridis, Nikolaos, additional, Michos, Athanasios, additional, De Rosa, Francesco Giuseppe, additional, Cavallo, Rossana, additional, Petrosillo, Nicola, additional, Dicaro, Antonio, additional, Landini, Maria Paola, additional, degli Atti, Marta Luisa Ciofi, additional, Masanovic, Mileva, additional, Matkovic, Dusan, additional, Tsiodras, Sotirios, additional, Blasi, Francesco, additional, pasquale, Marta Di, additional, Viscoli, Claudio, additional, Vata, Andrei, additional, Dorneanu, Olivia, additional, Kapisyzi, Perlat, additional, Vince, Adriana, additional, Tsigou, Evdoxia, additional, Maltezos, Efstratios, additional, Komnos, Apostolos, additional, Gogos, Charalampos, additional, Franzetti, Fabio, additional, Antonelli, Massimo, additional, Lupse, Mihaela, additional, Corneci, Dan, additional, Tomescu, Dana, additional, Georgescu, Anca, additional, Mitrović, Goran, additional, Krstić, Nataša Lukić, additional, Kurti, Arsim, additional, Reuter, Sandra, additional, Díaz-Pollán, Beatriz, additional, Sabater, Julia Origüen, additional, Muñoz, Patricia, additional, Azap, Alpay, additional, ancak, Banu, additional, Sahin, Arife, additional, and Akalin, Halis, additional

Published
2024
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15. Development of Meropenem Resistance in a Multidrug-Resistant Campylobacter coli Strain Causing Recurrent Bacteremia in a Hematological Malignancy Patient

Author

Bonilla-Moreno, María, primary, Torrecillas, Miriam, additional, Laporte-Amargos, Julia, additional, González-Díaz, Aída, additional, Mussetti, Alberto, additional, Tubau, Fe, additional, Gudiol, Carlota, additional, Domínguez, M. Angeles, additional, Martí, Sara, additional, Rodríguez-Sevilla, Graciela, additional, and Ardanuy, Carmen, additional

Published
2023
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16. Pseudomonas aeruginosa antibiotic susceptibility profiles, genomic epidemiology and resistance mechanisms: a nation-wide five-year time lapse analysis

Author

Sastre-Femenia, Miquel Àngel, primary, Fernández-Muñoz, Almudena, additional, Gomis-Font, María Antonia, additional, Taltavull, Biel, additional, López-Causapé, Carla, additional, Arca-Suárez, Jorge, additional, Martínez-Martínez, Luis, additional, Cantón, Rafael, additional, Larrosa, Nieves, additional, Oteo-Iglesias, Jesús, additional, Zamorano, Laura, additional, Oliver, Antonio, additional, Galán-Sánchez, Fátima, additional, Gracia-Ahufinger, Irene, additional, Liébana-Martos, Carmen, additional, Roldán, Carolina, additional, Sánchez-Calvo, Juan Manuel, additional, Clavijo, Encarnación, additional, Mora-Navas, Laura, additional, Aznar, Javier, additional, Lepe, José Antonio, additional, Rodríguez-Villodres, Ángel, additional, Recacha, Esther, additional, Casas-Círia, Francisco Javier, additional, Martínez-Rubio, Carmen, additional, Sempere-Alcocer, Marco Antonio, additional, Martín-Hita, Lina, additional, Seral, Cristina, additional, López-Calleja, Ana Isabel, additional, Aspiroz, Carmen, additional, Monforte, Marisa, additional, Iglesia-Martínez, Pedro de la, additional, Jimenez-Guerra, Gemma, additional, Riera-Pérez, Elena, additional, Collado, Carmen, additional, Gallegos, Carmen, additional, Mulet, Xavier, additional, Sastre-Femenía, Miquel Àngel, additional, Siller-Ruiz, María, additional, Calvo, Jorge, additional, Quesada, Dolores, additional, Wang, Jun Hao, additional, Pitart, Cristina, additional, Marco, Francesc, additional, Prim, Nuria, additional, Horcajada, Juan Pablo, additional, Padilla, Eduardo, additional, Del Barrio-Tofiño, Ester, additional, Viñado-Pérez, Belen, additional, Tubau, Fe, additional, Capilla, Silvia, additional, Casabella, Antonio, additional, Pérez-Moreno, Mar Olga, additional, Padilla, Emma, additional, Ballestero, Mónica, additional, Rivera, Alba, additional, Navarro, Ferrán, additional, Gómez-Bertomeu, Fréderic, additional, Pardo-Granell, Sergio, additional, Picó-Plana, Ester, additional, Guerrero, Dolores, additional, Sarvisé-Buil, Carolina, additional, Belles-Belles, Alba, additional, Fernández-Esgueva, Marta, additional, Ortega-Lafont, María del Pilar, additional, García, Inmaculada, additional, Arenal-Andrés, Noelia, additional, Hernando-Real, Susana, additional, Ibáñez, Rosario, additional, Martínez, Jesús, additional, Becerra, Federico, additional, Aldea-Mansilla, Carmen, additional, Alaoui-Sosse, Asmaa, additional, González, José Carlos, additional, Guzman-Puche, Julia, additional, Blázquez-Andrada, Miguel Ángel, additional, Martínez-Ramírez, Nora Mariela, additional, Beteta, Alicia, additional, Gomila-Sard, Bárbara, additional, Almaraz, Salvador Giner, additional, Garduño, Eugenio, additional, Juiz-González, Pedro Miguel, additional, Alba, Javier, additional, Alonso, Pilar, additional, Rodríguez, Ana Isabel, additional, Paz-Vidal, María Isabel, additional, García-Campello, Marta, additional, Camacho, Pablo, additional, Pallarés, María de los Ángeles, additional, Pérez del Molino, María Luisa, additional, Coira, Amparo, additional, Barbeito, Gema, additional, Rincón, Anniris, additional, Vasallo-Vidal, Francisco José, additional, Alonso-Acero, Laura, additional, Iglesias-Llorente, Laura, additional, Bordes-Benites, Ana, additional, Florén-Zabala, Laura, additional, Azcona, José Manuel, additional, Alonso, Carla Andrea, additional, Sáenz, Yolanda, additional, Lamata-Subero, Marta, additional, Molina, David, additional, González-Torralba, Ana, additional, Villa, Jennifer, additional, Viedma, Esther, additional, Cercenado, Emilia, additional, Alarcón, Teresa, additional, Vargas, Paula, additional, Díez, María, additional, Ruiz, Patricia, additional, Sánchez-Romero, María Isabel, additional, Pérez-García, Felipe, additional, Yagüe-Guirao, Genoveva, additional, Oteiza, Amaia Concepción, additional, Leiva, José, additional, Portillo, María Eugenia, additional, Canut-Blasco, Andrés, additional, Vidal, Matxalen, additional, Alonso, Iker, additional, Zuriarrain, Maider, additional, and Barrios-Andrés, José Luis, additional

Published
2023
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19. Long-Term Effects of a Stepwise, Multimodal, Non-Restrictive Antimicrobial Stewardship Programme for Reducing Broad-Spectrum Antibiotic Use in the ICU.

Author

Ronda, Mar, Gumucio-Sanguino, Victor Daniel, Shaw, Evelyn, Granada, Rosa, Tubau, Fe, Santafosta, Eva, Sabater, Joan, Esteve, Francisco, Tebé, Cristian, Mañez, Rafael, Carratalà, Jordi, Puig-Asensio, Mireia, Cobo-Sacristán, Sara, and Padullés, Ariadna

Subjects
ANTIMICROBIAL stewardship, ANTIBIOTICS, INTENSIVE care units, POISSON regression, DRUG prescribing
Abstract

Information on the long-term effects of non-restrictive antimicrobial stewardship (AMS) strategies is scarce. We assessed the effect of a stepwise, multimodal, non-restrictive AMS programme on broad-spectrum antibiotic use in the intensive care unit (ICU) over an 8-year period. Components of the AMS were progressively implemented. Appropriateness of antibiotic prescribing was also assessed by monthly point-prevalence surveys from 2013 onwards. A Poisson regression model was fitted to evaluate trends in the reduction of antibiotic use and in the appropriateness of their prescription. From 2011 to 2019, a total of 12,466 patients were admitted to the ICU. Antibiotic use fell from 185.4 to 141.9 DDD per 100 PD [absolute difference, −43.5 (23%), 95% CI −100.73 to 13.73; p = 0.13] and broad-spectrum antibiotic fell from 41.2 to 36.5 [absolute difference, −4.7 (11%), 95% CI −19.58 to 10.18; p = 0.5]. Appropriateness of antibiotic prescribing rose by 11% per year [IRR: 0.89, 95% CI 0.80 to 1.00; p = 0.048], while broad-spectrum antibiotic use showed a dual trend, rising by 22% until 2015 and then falling by 10% per year since 2016 [IRR: 0.90, 95% CI 0.81 to 0.99; p = 0.03]. This stepwise, multimodal, non-restrictive AMS achieved a sustained reduction in broad-spectrum antibiotic use in the ICU and significantly improved appropriateness of antibiotic prescribing. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Activity of imipenem/relebactam against Enterobacterales and Pseudomonas aeruginosa in Spain. SMART 2016-2020

Author

García-Fernández, Sergio, primary, Calvo, Jorge, additional, Cercenado, Emilia, additional, Suárez-Barrenechea, Ana Isabel, additional, Fernández-Billón, María, additional, Castillo, Francisco Javier, additional, Gálvez-Benítez, Lydia, additional, Tubau, Fe, additional, Figueroa Cerón, Ruth Esther, additional, Hernández-Cabezas, Alicia, additional, González Romo, Fernando, additional, Fariñas, María Carmen, additional, Gómez, María, additional, Díaz-Regañón, Jazmín, additional, and Cantón, Rafael, additional

Published
2023
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25. Risk factors for infections caused by carbapenem-resistant Enterobacterales: an international matched case-control-control study (EURECA)

Author

Pérez-Galera, Salvador, primary, Bravo-Ferrer, Jose M., additional, Paniagua, María, additional, Kostyanev, Tomislav, additional, de Kraker, Marlieke E.A., additional, Feifel, Jan, additional, Sojo-Dorado, Jesús, additional, Schotsman, Joost, additional, Cantón, Rafael, additional, Daikos, George L., additional, Carevic, Biljana, additional, Dragovac, Gorana, additional, Tan, Lionel K., additional, Raka, Lul, additional, Hristea, Adriana, additional, Viale, Pierluigi, additional, Akova, Murat, additional, Reguera, Jose María, additional, Valiente de Santis, Lucía, additional, Torre-Cisneros, Julián, additional, Cano, Ángela, additional, Roilides, Emmanuel, additional, Radulovic, Lili, additional, Kirakli, Cenk, additional, Shaw, Evelyn, additional, Falagas, Matthew E., additional, Pintado, Vicente, additional, Goossens, Herman, additional, Bonten, Marc J., additional, Gutiérrez-Gutiérrez, Belén, additional, Rodriguez-Baño, Jesús, additional, de la Serna, Almudena, additional, Monteau, Sophie, additional, Palomo, Virginia, additional, Soriano, Elena, additional, Gutierrez, David, additional, Moreno, Elisa, additional, Palacios, Zaira, additional, Morales, Isabel, additional, Maldonado, Natalia, additional, Ciezar, Antonio Plata, additional, Ruiz Mesa, Juan Diego, additional, Diaz, Beatriz Sobrino, additional, Gomez, Ignacio Marquez, additional, Camacho, Ines Perez, additional, Frutos-Adame, Azahara, additional, Guzman-Puche, Julia, additional, Gracia-Ahufinger, Irene, additional, Perez-Nadales, Elena, additional, Torre-Gimenez, Julian, additional, Pyrpasopoulou, Athina, additional, Iosifidis, Elias, additional, Chorafa, Elsa, additional, Radovanovic, Ivana, additional, Petrovic, Sladjana, additional, Cvetkovi, Slavica, additional, Melentijevic, Srdjan-Sanja, additional, Bicmen, Can, additional, Senol, Gunes, additional, Tubau, Fe, additional, Camara, Jordi, additional, Gumucio, Victor Daniel, additional, Bassoulis, Dimitris, additional, Deliolanis, John, additional, Pitiriga, Vassiliki Ch., additional, Triarides, Nikolaos, additional, Argiti, Efstathia, additional, Legakis, Nikolaos J., additional, Margarita, Kyriakidou, additional, Gijón-Cordero, Desirée, additional, Ruiz-Garbajosa, Patricia, additional, Bartoloni, Alessandro, additional, Rossolini, Gian Maria, additional, Florescu, Simin-Aysel, additional, Nica, Maria, additional, Benea, Serban, additional, Talapan, Daniela, additional, Medić, Deana, additional, Prijić, Sanja Maričić, additional, Caballero, Mireia Cantero, additional, Parra Ramírez, Lina M., additional, Korten, Volkan, additional, Bilgin, Hüseyin, additional, Dalekos, George N., additional, Stefos, Aggelos, additional, Spyridis, Nikolaos, additional, Michos, Athanasios, additional, De Rosa, Francesco Giuseppe, additional, Cavallo, Rossana, additional, Petrosillo, Nicola, additional, Dicaro, Antonio, additional, Landini, Maria Paola, additional, Ciofi degli Atti, Marta Luisa, additional, Masanovic, Mileva, additional, Matkovic, Dusan, additional, Tsiodras, Sotirios, additional, Blasi, Francesco, additional, Di pasquale, Marta, additional, Viscoli, Claudio, additional, Vata, Andrei, additional, Dorneanu, Olivia, additional, Kapisyzi, Perlat, additional, Vince, Adriana, additional, Tsigou, Evdoxia, additional, Maltezos, Efstratios, additional, Komnos, Apostolos, additional, Gogos, Charalampos, additional, Franzetti, Fabio, additional, Antonelli, Massimo, additional, Lupse, Mihaela, additional, Corneci, Dan, additional, Tomescu, Dana, additional, Georgescu, Anca, additional, Bukarica, Ljiljana, additional, Mitrović, Goran, additional, Krstić, Nataša Lukić, additional, Kurti, Arsim, additional, Díaz-Pollán, Beatriz, additional, Sabater, Julia Origüen, additional, Muñoz, Patricia, additional, Azap, Alpay, additional, Sancak, Banu, additional, Sahin, Arife, additional, and Akalin, Halis, additional

Published
2023
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26. Genetic Adaptation and Acquisition of Macrolide Resistance in Haemophilus spp. during Persistent Respiratory Tract Colonization in Chronic Obstructive Pulmonary Disease (COPD) Patients Receiving Long-Term Azithromycin Treatment

Author

Fundación Respira, Ministerio de Sanidad (España), Fundació Catalana de Pneumologia, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Centro de Investigación Biomédica en Red Enfermedades Respiratorias (España), Instituto de Salud Carlos III, European Commission, Generalitat de Catalunya, Ministerio de Educación, Cultura y Deporte (España), Carrera-Salinas, Anna, González-Díaz, Aida, Ehrlich, Rachel L., Berbel, Dàmaris, Tubau, Fe, Pomares, Xavier, Garmendia, Juncal, Domínguez, M. Ángeles, Ardanuy, Carmen, Huertas, Daniel, Marín, Alicia, Montón, Conchita, Mell, Joshua Chang, Santos, Salud, Martí, Sara, Fundación Respira, Ministerio de Sanidad (España), Fundació Catalana de Pneumologia, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Centro de Investigación Biomédica en Red Enfermedades Respiratorias (España), Instituto de Salud Carlos III, European Commission, Generalitat de Catalunya, Ministerio de Educación, Cultura y Deporte (España), Carrera-Salinas, Anna, González-Díaz, Aida, Ehrlich, Rachel L., Berbel, Dàmaris, Tubau, Fe, Pomares, Xavier, Garmendia, Juncal, Domínguez, M. Ángeles, Ardanuy, Carmen, Huertas, Daniel, Marín, Alicia, Montón, Conchita, Mell, Joshua Chang, Santos, Salud, and Martí, Sara

Abstract

Patients with chronic obstructive pulmonary disease (COPD) benefit from the immunomodulatory effect of azithromycin, but long-term administration may alter colonizing bacteria. Our goal was to identify changes in Haemophilus influenzae and Haemophilus parainfluenzae during azithromycin treatment. Fifteen patients were followed while receiving prolonged azithromycin treatment (Hospital Universitari de Bellvitge, Spain). Four patients (P02, P08, P11, and P13) were persistently colonized by H. influenzae for at least 3 months and two (P04 and P11) by H. parainfluenzae. Isolates from these patients (53 H. influenzae and 18 H. parainfluenzae) were included to identify, by whole-genome sequencing, antimicrobial resistance changes and genetic variation accumulated during persistent colonization. All persistent lineages isolated before treatment were azithromycin-susceptible but developed resistance within the first months, apart from those belonging to P02, who discontinued the treatment. H. influenzae isolates from P08-ST107 acquired mutations in 23S rRNA, and those from P11-ST2480 and P13-ST165 had changes in L4 and L22. In H. parainfluenzae, P04 persistent isolates acquired changes in rlmC, and P11 carried genes encoding MefE/MsrD efflux pumps in an integrative conjugative element, which was also identified in H. influenzae P11-ST147. Other genetic variation occurred in genes associated with cell wall and inorganic ion metabolism. Persistent H. influenzae strains all showed changes in licA and hgpB genes. Other genes (lex1, lic3A, hgpC, and fadL) had variation in multiple lineages. Furthermore, persistent strains showed loss, acquisition, or genetic changes in prophage-associated regions. Long-term azithromycin therapy results in macrolide resistance, as well as genetic changes that likely favor bacterial adaptation during persistent respiratory colonization. IMPORTANCE The immunomodulatory properties of azithromycin reduce the frequency of exacerbations and improve the

Published
2023

29. Genetic Adaptation and Acquisition of Macrolide Resistance in Haemophilus spp. during Persistent Respiratory Tract Colonization in Chronic Obstructive Pulmonary Disease (COPD) Patients Receiving Long-Term Azithromycin Treatment

Author

Carrera-Salinas, Anna, primary, González-Díaz, Aida, additional, Ehrlich, Rachel L., additional, Berbel, Dàmaris, additional, Tubau, Fe, additional, Pomares, Xavier, additional, Garmendia, Junkal, additional, Domínguez, M. Ángeles, additional, Ardanuy, Carmen, additional, Huertas, Daniel, additional, Marín, Alicia, additional, Montón, Conchita, additional, Mell, Joshua Chang, additional, Santos, Salud, additional, and Marti, Sara, additional

Published
2023
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32. Molecular Epidemiology, Antimicrobial Susceptibility, and Clinical Features of Methicillin-Resistant Staphylococcus aureus Bloodstream Infections over 30 Years in Barcelona, Spain (1990–2019)

Author

Vázquez-Sánchez, Daniel Antonio, primary, Grillo, Sara, additional, Carrera-Salinas, Anna, additional, González-Díaz, Aida, additional, Cuervo, Guillermo, additional, Grau, Inmaculada, additional, Camoez, Mariana, additional, Martí, Sara, additional, Berbel, Dàmaris, additional, Tubau, Fe, additional, Ardanuy, Carmen, additional, Pujol, Miquel, additional, Càmara, Jordi, additional, and Domínguez, Mª Ángeles, additional

Published
2022
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34. Influence of Virulence Genotype and Resistance Profile in the Mortality of Pseudomonas aeruginosa Bloodstream Infections

Author

Spanish Network for Research in Infectious Diseases (REIPI), Peña, Carmen, Cabot, Gabriel, Gómez-Zorrilla, Silvia, Zamorano, Laura, Ocampo-Sosa, Alain, Murillas, Javier, Almirante, Benito, Pomar, Virginia, Aguilar, Manuela, Granados, Ana, Calbo, Esther, Rodríguez-Baño, Jesús, Rodríguez-López, Fernando, Tubau, Fe, Martínez-Martínez, Luis, and Oliver, Antonio

Published
2015

35. Efficacy and Safety of Fosfomycin Plus Imipenem as Rescue Therapy for Complicated Bacteremia and Endocarditis Due to Methicillin-Resistant Staphylococcus aureus: A Multicenter Clinical Trial

Author

FOSIMI Investigators, del Río, Ana, Gasch, Oriol, Moreno, Asunción, Peña, Carmen, Cuquet, Jordi, Soy, Dolors, Mestres, Carlos A., Suárez, Cristina, Pare, Juan C., Tubau, Fe, de la Mària, Cristina Garcia, Marco, Francesc, Carratalà, Jordi, Gatell, José M., Gudiol, Francisco, and Miró, José M.

Published
2014
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37. Effect of Adequate Single-Drug vs Combination Antimicrobial Therapy on Mortality in Pseudomonas aeruginosa Bloodstream Infections: A Post Hoc Analysis of a Prospective Cohort

Author

Spanish Network for Research in Infectious Diseases (REIPI), Peña, Carmen, Suarez, Cristina, Ocampo-Sosa, Alain, Murillas, Javier, Almirante, Benito, Pomar, Virginia, Aguilar, Manuela, Granados, Ana, Calbo, Esther, Rodríguez-Baño, Jesús, Rodríguez, Fernando, Tubau, Fe, Oliver, Antonio, and Martínez-Martínez, Luis

Published
2013
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40. Emergence of 16S rRNA methyltransferases among carbapenemase-producing Enterobacterales in Spain studied by whole-genome sequencing

Author

Arca-Suárez, Jorge, primary, Rodiño-Janeiro, Bruno K., additional, Pérez, Astrid, additional, Guijarro-Sánchez, Paula, additional, Vázquez-Ucha, Juan C., additional, Cruz, Fernando, additional, Gómez-Garrido, Jèssica, additional, Alioto, Tyler S., additional, Álvarez-Tejado, Miguel, additional, Gut, Marta, additional, Gut, Ivo, additional, Oviaño, Marina, additional, Beceiro, Alejandro, additional, Bou, Germán, additional, Merino, Irene, additional, Cercenado, Emilia, additional, Gómez, Rosa, additional, Soler, Tamara, additional, Gracia-Ahufinger, Irene, additional, Martín, Lina, additional, Galán, Fátima, additional, Tormo, Nuria, additional, Rodríguez, Juan Carlos, additional, Capilla, Silvia, additional, Marco, Francesc, additional, Quesada, María Dolores, additional, Padilla, Emma, additional, Tubau, Fe, additional, González, Juanjo, additional, López-Calleja, Ana Isabel, additional, del Pozo, José Luis, additional, García, María Inmaculada, additional, Martinez, Mariela, additional, Calvo, Jorge, additional, Mulet, Xavier, additional, Peña, Fernanda, additional, Rodríguez, Ana Isabel, additional, Gude, María José, additional, Fernández, Ana, additional, and Fernández, Javier, additional

Published
2022
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41. Epidemiology and population structure of Haemophilus influenzae causing invasive disease

Author

Carrera-Salinas, Anna, primary, González-Díaz, Aida, additional, Calatayud, Laura, additional, Mercado-Maza, Julieta, additional, Puig, Carmen, additional, Berbel, Dàmaris, additional, Càmara, Jordi, additional, Tubau, Fe, additional, Grau, Imma, additional, Domínguez, M. Ángeles, additional, Ardanuy, Carmen, additional, and Martí, Sara, additional

Published
2021
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45. Reduced susceptibility to biocides in Acinetobacter baumannii: association with resistance to antimicrobials, epidemiological behaviour, biological cost and effect on the expression of genes encoding porins and efflux pumps

Author

Fernández-Cuenca, Felipe, Tomás, María, Caballero-Moyano, Francisco-Javier, Bou, Germán, Martínez-Martínez, Luis, Vila, Jordi, Pachón, Jerónimo, Cisneros, José-Miguel, Rodríguez-Baño, Jesús, Pascual, Álvaro, Garnacho, José, Gutierrez-Pizarraya, Antonio, Márquez-Vácaro, Juan Antonio, Cano, María Eliecer, Fariñas, M. Carmen, Sánchez-Porto, Antonio, Meruendano, Gloria Esteban, Barbeyto-Vales, Luis, Casas-Ciria, Javier, Vallejo, Luis, Fernández-Pérez, Begona, Villar-Chao, José Carlos, Padilla-Ortega, Belén, Cercenado-Mansilla, Emilia, García-Irure, José Javier, del Arco Jiménez, Alfonso, Gimeno-Cardona, Concepción, Valía, Juan Carlos, Tormo-Palop, Núria, Abril, Vicente, Rifa, Josefina, Martinez-Garcia, Maria Jesus, Vilaró-Pujals, Joseph, Aguirre, Marian Navarro, Vilamala, Ana, Jiménez-Alfaro, José Antonio, Reviejo-Jaca, Carlos, Casanova, Pilar Marín, Guerreo, Francisca, Shaw, Evelyn, Plasencia, Virginia, Nebreda-Mayoral, Teresa, Fernández-Calavia, María José, de Cruz, Susana García, Aldea-Mansilla, Carmen, de Lucas, Esperanza Merino, Zorraquino, Alfredo, Reus-Bañuls, Sergio, Garduno-Eseverri, Eugenio, Sánchez, Luis López, Fleites-Gutiérrez, Ana, Rodríguez-Guardado, Azucena, Moreno, Alfonso, García-Arenzana Anguera, José María, López-Palmero, Serafín, Rodríguez-Maresca, Manuel, García-Garrote, Fernando, Varela-Otero, José, del Pilar Alonso, María, Vidal-Verdú, Elisa, Rodríguez-López, Fernando, Pardo-Sánchez, Fernanda, Ferrer-Vizoso, E., Regueiro-Garcia, B., Gurgui, Mercé, Pericas, Roser, Pomar, Virginia, Olaechea-Astigarraga, Pedro María, Ayarza-Igartua, Rafael, Maciá-Romero, María Dolores, de Gopegui-Bordes, Enrique Ruiz, Sánchez-Romero, María Isabel, García-Mata, Jesús, Goyanes, María José, Morales-Mateos, Cristina, Hernández-Quero, José, Escobar-Lara, Trinidad, Ballester-Bastardie, Frederic, Iftimie, Simona, Pujol-Bajador, Isabel, Galán-Navarro, María Isabel, Cádiz-Gurrea, María Luz, Amores-Antequera, Carmen, Gómez, Montserrat, Cantudo, Purificación, Martí-Salas, Carmina, Cuquet-Peragosa, Jordi, Moreno-Flores, Antonio, Anibarro-García, Luis, Hernando-Real, Susana, Carrero-González, Pablo A., Pallarés-González, María Angeles, Rodríguez-Fernández, Sergio, Pujol-Rojo, Miquel, Tubau, Fe, Nuno-Alvarez, Enrique, Ortega-Torres, María, Giner-Almaraz, Salvador, Roca-Castelló, María Rosa, Castillo, Manuela, Hortelano, Elena, Chaves-Sánchez, Fernando, García-Reyne, Ana, Horcajada-Gallego, Juan Pablo, Segura, Concha, Sierra-Dorado, Gema, Yano-Escudero, Raquel, Dorta-Hung, María Elena, and del Rosario Q, Cristóbal

Published
2015
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46. A novel genomic island harbouring lsa(E) and lnu(B) genes and a defective prophage in a Streptococcus pyogenes isolate resistant to lincosamide, streptogramin A and pleuromutilin antibiotics

Author

Instituto de Salud Carlos III, European Commission, García, Ernesto [0000-0002-1741-5486], Tubau, Fe [0000-0002-6416-6451], Giard, Jean-Christophe [0000-0001-8588-2732], Cattoir, Vincent [0000-0003-4026-9912], Ardanuy, Carmen [0000-0003-0225-607X], Berbel, Dàmaris, Cámara, Jordi, García, Ernesto, Tubau, Fe, Guérin, François, Giard, Jean-Christophe, Domínguez, M. Ángeles, Cattoir, Vincent, Ardanuy, Carmen, Instituto de Salud Carlos III, European Commission, García, Ernesto [0000-0002-1741-5486], Tubau, Fe [0000-0002-6416-6451], Giard, Jean-Christophe [0000-0001-8588-2732], Cattoir, Vincent [0000-0003-4026-9912], Ardanuy, Carmen [0000-0003-0225-607X], Berbel, Dàmaris, Cámara, Jordi, García, Ernesto, Tubau, Fe, Guérin, François, Giard, Jean-Christophe, Domínguez, M. Ángeles, Cattoir, Vincent, and Ardanuy, Carmen

Abstract

A lincosamide-resistant and macrolide-susceptible phenotype has not been described to date in Streptococcus pyogenes [group A streptococcus (GAS)]. The aim of this study was to characterize a GAS isolate susceptible to macrolides but resistant to lincosamide, streptogramin A and pleuromutilin antibiotics. Antimicrobial susceptibility was tested using the microdilution broth method and the resistance phenotype was tested by D-test. The GAS2887HUB isolate was subjected to whole-genome sequencing. The isolate showed a positive Gots' test (clindamycin inactivation). Whole-genome sequencing revealed that the strain was ST10 and emm93, and had five resistance genes [lnu(B), ant(6)-Ia, aph(3')-III, tet(M) and dfrG]. The tet(M) gene was located in a Tn916-like transposon. The lsa(E)-lnu(B)-containing sequence (inserted downstream of the rumA gene) was formed by a 39.6-kb prophage, followed by a gene cluster encoding aminoglycoside-streptothricin resistance [ant(6)Ia-sat4-aph(3')III] and lsa(E)-lnu(B) genes. This structure was not transferred by conjugation. This study identified a new genetic element carrying a determinant of lincosamide resistance in a GAS. Further molecular epidemiological surveys are needed to determine the prevalence of this mechanism of resistance in GAS.

Published
2019

48. Predicting Pseudomonas aeruginosa susceptibility phenotypes from whole genome sequence resistome analysis

Author

Cortes-Lara, Sara, primary, Barrio-Tofiño, Ester del, additional, López-Causapé, Carla, additional, Oliver, Antonio, additional, Martínez-Martínez, Luis, additional, Bou, Germán, additional, Zamorano, Laura, additional, Sánchez-Diener, Irina, additional, Galán, Fátima, additional, Gracia, Irene, additional, Rodríguez, Manuel Antonio, additional, Martín, Lina, additional, Sánchez, Juan Manuel, additional, Viñuela, Laura, additional, García, Ma Victoria, additional, Lepe, José Antonio, additional, Aznar, Javier, additional, López-Hernández, Inma, additional, Seral, Cristina, additional, Castillo-García, Francisco Javier, additional, López-Calleja, Ana Isabel, additional, Aspiroz, Carmen, additional, Iglesia, Pedro de la, additional, Ramón, Susana, additional, Riera, Elena, additional, Pérez, María Cruz, additional, Gallegos, Carmen, additional, Calvo, Jorge, additional, Quesada, María Dolores, additional, Pitart, Cristina, additional, Marco, Francesc, additional, Hoyos, Yannick, additional, Horcajada, Juan Pablo, additional, Larrosa, Nieves, additional, González, Juan José, additional, Tubau, Fe, additional, Capilla, Silvia, additional, Pérez-Moreno, Mar Olga, additional, Centelles, Ma José, additional, Padilla, Emma, additional, Rivera, Alba, additional, Mirelis, Beatriz, additional, Rodríguez-Tarazona, Raquel Elisa, additional, Arenal-Andrés, Noelia, additional, Ortega, María del Pilar, additional, Megías, Gregoria, additional, García, Inmaculada, additional, Colmenarejo, Cristina, additional, González, José Carlos, additional, Martínez, Nora Mariela, additional, Gomila, Bárbara, additional, Giner, Salvador, additional, Tormo, Nuria, additional, Garduño, Eugenio, additional, Agulla, José Andrés, additional, Seoane, Alejandro, additional, Pita, Julia, additional, Vidal, Isabel Paz, additional, Guzmán, David Mauricio, additional, García, Marta, additional, Pérez del Molino, María Luisa, additional, Barbeito, Gema, additional, Artiles, Fernando, additional, Azcona-Gutiérrez, José Manuel, additional, Sáenz, Yolanda, additional, Oteo, José Antonio, additional, González, Ana, additional, Villa, Jennifer, additional, Chaves, Fernando, additional, Cercenado, Emilia, additional, Alarcón, Teresa, additional, Zurita, Nelly Daniela, additional, Gijón, Desiré, additional, Merino, Irene, additional, Morosini, María Isabel, additional, Cantón, Rafael, additional, Sánchez, María Isabel, additional, Moreno, Laura, additional, Yagüe, Genoveva, additional, Leiva, José, additional, Barrios, José Luis, additional, Canut, Andrés, additional, and Oteo, Jesús, additional

Published
2021
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50. Infectious diseases experts as part of the antibiotic stewardship team in primary care: protocol for a cluster-randomised blinded study (IDASP)

Author

Ronda, Mar, primary, Padullés, Ariadna, additional, Simonet, Pere, additional, Rodríguez, Gemma, additional, Estrada, Cinta, additional, Lérida, Ana, additional, Ferro, Juan José, additional, Cobo, Sara, additional, Tubau, Fe, additional, Gardeñes, Lluïsa, additional, Freixedas, Rosa, additional, López, Montserrat, additional, Carrera, Elena, additional, Pallarés, Natàlia, additional, Tebe, Cristian, additional, Carratala, Jordi, additional, Puig-Asensio, Mireia, additional, and Shaw, Evelyn, additional

Published
2021
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