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Your search keyword '"Tubita, Valeria"' showing total 24 results
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24 results on '"Tubita, Valeria"'

1. Effect of Hormones as Cofactors in Food Allergy

Author

Mir-Ihara, Patricia, González-Matamala, Maria-Fernanda, Ruano-Zaragoza, Maria, Loli-Ausejo, David, Garcia-Garcia, Lucia, Tubita, Valeria, Pascal, Mariona, Martínez-Zamora, Maria-Ángeles, Bartra, Joan, and Muñoz-Cano, Rosa

Published
2024
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3. #2908 Renal progenitor cells an early non-invasive biomarker of silent kidney injury in Fabry disease

Author

Ugalde-Altamirano, Jessica, primary, Juarez, Jordi Rovira, additional, Tubita, Valeria, additional, Plana, Josep Maria Campistol, additional, Poch, Esteban, additional, Diekmann, Fritz, additional, Piñeiro, Gaston, additional, Cucchiari, David, additional, Azorin, Sebastian, additional, Banon, Elisenda, additional, Corral-Velez, Vicente, additional, and Prats, José Vicente Torregrosa, additional

Published
2024
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6. Effect of Obesity on the Expression of Genes Associated with Severe Asthma—A Pilot Study

Author

Bantulà, Marina, primary, Arismendi, Ebymar, additional, Tubita, Valeria, additional, Roca-Ferrer, Jordi, additional, Mullol, Joaquim, additional, de Hollanda, Ana, additional, Sastre, Joaquín, additional, Valero, Antonio, additional, Baos, Selene, additional, Cremades-Jimeno, Lucía, additional, Cárdaba, Blanca, additional, and Picado, César, additional

Published
2023
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15. Effect of MP-AzeFlu compared to monotherapy on COX-2, PGE2, and EP2 gene expression in upper airway mucosa.

Author

Vicens-Artes, Sonia, Roca-Ferrer, Jordi, Tubita, Valeria, Fuentes, Mireya, Alobid, Isam, Valero, Antonio, Kopietz, Ferdinand, DucTung Nguyen, and Mullol, Joaquim

Subjects
CYCLOOXYGENASE 2, GENE expression, MUCOUS membranes, FLUTICASONE propionate, MESSENGER RNA
Abstract

MP-AzeFlu (intranasal fluticasone and azelastine) has been widely studied and has demonstrated efficacy in Allergic rhinitis with a superior effect compared to these drugs administered individually; however, the mechanism by which MP-AzeFlu produces this improved clinical effect has not yet been fully explained. In this study, we investigated the effect of MP-AzeFlu and fluticasone propionate (FP) on arachidonic acid metabolism as measured by changes in regulation of cyclooxygenase (COX) isoforms, prostaglandin (PG) D2, PGE2, PGE2 receptor (EP) 2, and EP3. Expression of these key inflammation markers was assessed through an in vitro model of upper airway inflammation using fibroblasts derived from both healthy and inflamed upper airway mucosa. Both MP-AzeFlu and FP inhibited interleukin-1β-induced COX-2 messenger RNA (mRNA) and protein expression and PGE2 secretion in vitro. MP-AzeFlu and FP both upregulated EP2 mRNA expression, though neither upregulated EP2 protein expression. This downregulation of COX-2 and PGE2 coupled with upregulation of EP2 receptor expression reinforces the anti-inflammatory effect of MP-AzeFlu in upper airway inflammation. [ABSTRACT FROM AUTHOR]

Published
2023
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16. Superior effect of MP‐AzeFlu compared to monotherapy with fluticasone propionate or azelastine on GILZ, MKP‐1, and TTP anti‐inflammatory gene expression in healthy and inflamed upper airway mucosa

Author

Vicens‐Artés, Sònia, primary, Roca‐Ferrer, Jordi, additional, Tubita, Valeria, additional, Fuentes, Mireya, additional, Alobid, Isam, additional, Valero, Antonio, additional, Kopietz, Ferdinand, additional, Nguyen, DucTung, additional, and Mullol, Joaquim, additional

Published
2022
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17. B Cell-Derived Extracellular Vesicles Reveal Residual B Cell Activity in Kidney Graft Recipients Undergoing Pre-Transplant Desensitization

Author

Cucchiari, David, primary, Tubita, Valeria, additional, Rovira, Jordi, additional, Ramirez-Bajo, Maria J., additional, Banon-Maneus, Elisenda, additional, Lazo-Rodriguez, Marta, additional, Hierro-Garcia, Natalia, additional, Borràs, Francesc E., additional, Ventura-Aguiar, Pedro, additional, Piñeiro, Gastón J., additional, Martorell, Jaume, additional, Peri, Lluís, additional, Musquera, Mireia, additional, Hertig, Alexandre, additional, Oppenheimer, Federico, additional, Campistol, Josep M., additional, Diekmann, Fritz, additional, and Revuelta, Ignacio, additional

Published
2021
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22. Impact of Mesenchymal Stromal Cells and Their Extracellular Vesicles in a Rat Model of Kidney Rejection

Author

Ramirez-Bajo, Maria Jose, primary, Rovira, Jordi, additional, Lazo-Rodriguez, Marta, additional, Banon-Maneus, Elisenda, additional, Tubita, Valeria, additional, Moya-Rull, Daniel, additional, Hierro-Garcia, Natalia, additional, Ventura-Aguiar, Pedro, additional, Oppenheimer, Federico, additional, Campistol, Josep M., additional, and Diekmann, Fritz, additional

Published
2020
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23. Role of microRNAs in inflammatory upper airway diseases.

Author

Tubita, Valeria, Callejas‐Díaz, Borja, Roca‐Ferrer, Jordi, Marin, Concepció, Liu, Zheng, Wang, De Yun, and Mullol, Joaquim

Subjects
*AIRWAY (Anatomy), *NON-coding RNA, *MICRORNA, *NASAL polyps, *B cells, *PATHOGENESIS
Abstract

MicroRNAs (miRNAs) are a conserved family of small endogenous noncoding RNA molecules that modulate post‐transcriptional gene expression in physiological and pathological processes. miRNAs can silence target mRNAs through degradation or inhibition of translation, showing their pivotal role in the pathogenesis of many human diseases. miRNAs play a role in regulating immune functions and inflammation and are implicated in controlling the development and activation of T and B cells. Inflammatory chronic upper airway diseases, such as rhinitis and rhinosinusitis, are spread all over the world and characterized by an exaggerated inflammation involving a complex interaction between immune and resident cells. Until now and despite allergy, little is known about their etiology and the processes implicated in the immune response and tuning inflammation of these diseases. This review highlights the knowledge of the current literature about miRNAs in inflammatory chronic upper airways diseases and how this may be exploited in the development of new clinical and therapeutic strategies. [ABSTRACT FROM AUTHOR]

Published
2021
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24. Effect of MP-AzeFlu compared to monotherapy on COX-2, PGE 2 , and EP2 gene expression in upper airway mucosa.

Author

Vicens-Artes S, Roca-Ferrer J, Tubita V, Fuentes M, Alobid I, Valero A, Kopietz F, Nguyen D, and Mullol J

Subjects
Humans, Cyclooxygenase 2 genetics, Fluticasone therapeutic use, RNA, Messenger, Inflammation drug therapy, Dinoprostone, Mucous Membrane
Abstract

MP-AzeFlu (intranasal fluticasone and azelastine) has been widely studied and has demonstrated efficacy in Allergic rhinitis with a superior effect compared to these drugs administered individually; however, the mechanism by which MP-AzeFlu produces this improved clinical effect has not yet been fully explained. In this study, we investigated the effect of MP-AzeFlu and fluticasone propionate (FP) on arachidonic acid metabolism as measured by changes in regulation of cyclooxygenase (COX) isoforms, prostaglandin (PG) D 2 , PGE 2 , PGE 2 receptor (EP) 2, and EP3. Expression of these key inflammation markers was assessed through an in vitro model of upper airway inflammation using fibroblasts derived from both healthy and inflamed upper airway mucosa. Both MP-AzeFlu and FP inhibited interleukin-1β-induced COX-2 messenger RNA (mRNA) and protein expression and PGE 2 secretion in vitro. MP-AzeFlu and FP both upregulated EP2 mRNA expression, though neither upregulated EP2 protein expression. This downregulation of COX-2 and PGE 2 coupled with upregulation of EP2 receptor expression reinforces the anti-inflammatory effect of MP-AzeFlu in upper airway inflammation., (© 2022 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd.)

Published
2023
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