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Machine Learning (ML) algorithms have become popular in many fields, including applications related to turbomachinery and heat transfer. The key properties of ML are the capability to partially tackle the problem of slowing down of Moore’s law and to dig-out correlations within large datasets like those available on turbomachinery. Data come from experiments and simulations with different degree of accuracy, according to the test-rig or the CFD approach. When dealing with modelling of turbulent flows in turbomachinery there is a constant trade-off between accuracy and computational costs, but starting from the large amount of data on turbomachinery performance, with ML it is possible to train a learner to correct and improve CFD. The aim of this work is to investigate an innovative data-driven approach that could lead to a significant improvement in the analysis of heat transfer in turbulent flows. The effects of Reynolds number and wall temperature on heat transfer for a double forward-facing step with two squared obstacles were investigated by numerical simulations carried out in OpenFOAM. Then a machine-learnt model was derived using a regression algorithm. The results of regressor showed that a data-driven approach can effectively predict results of the RANS model.