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1. Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions

Author

Müller, Paul M., Rademacher, Juliane, Bagshaw, Richard D., Wortmann, Celina, Barth, Carolin, van Unen, Jakobus, Alp, Keziban M., Giudice, Girolamo, Eccles, Rebecca L., Heinrich, Louise E., Pascual-Vargas, Patricia, Sanchez-Castro, Marta, Brandenburg, Lennart, Mbamalu, Geraldine, Tucholska, Monika, Spatt, Lisa, Czajkowski, Maciej T., Welke, Robert-William, Zhang, Sunqu, Nguyen, Vivian, Rrustemi, Trendelina, Trnka, Philipp, Freitag, Kiara, Larsen, Brett, Popp, Oliver, Mertins, Philipp, Gingras, Anne-Claude, Roth, Frederick P., Colwill, Karen, Bakal, Chris, Pertz, Olivier, Pawson, Tony, Petsalaki, Evangelia, and Rocks, Oliver

Published
2020
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2. The plasma peptides of breast versus ovarian cancer

Author

Dufresne, Jaimie, Bowden, Pete, Thavarajah, Thanusi, Florentinus-Mefailoski, Angelique, Chen, Zhuo Zhen, Tucholska, Monika, Norzin, Tenzin, Ho, Margaret Truc, Phan, Morla, Mohamed, Nargiz, Ravandi, Amir, Stanton, Eric, Slutsky, Arthur S., dos Santos, Claudia C., Romaschin, Alexander, Marshall, John C., Addison, Christina, Malone, Shawn, Heyland, Daren, Scheltens, Philip, Killestein, Joep, Teunissen, Charlotte, Diamandis, Eleftherios P., Siu, K. W. M., and Marshall, John G.

Published
2019
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3. The plasma peptidome

Author

Dufresne, Jaimie, Bowden, Pete, Thavarajah, Thanusi, Florentinus-Mefailoski, Angelique, Chen, Zhuo Zhen, Tucholska, Monika, Norzin, Tenzin, Ho, Margaret Truc, Phan, Morla, Mohamed, Nargiz, Ravandi, Amir, Stanton, Eric, Slutsky, Arthur S., dos Santos, Claudia C., Romaschin, Alexander, Marshall, John C., Addison, Christina, Malone, Shawn, Heyland, Daren, Scheltens, Philip, Killestein, Joep, Teunissen, Charlotte, Diamandis, Eleftherios P., Siu, K. W. M., and Marshall, John G.

Published
2018
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5. Plasma Peptidome

Author

Dufresne, Jaimie, primary, Bowden, Pete, primary, Thavarajah, Thanusi, primary, Florentinus-Mefailoski, Angelique, primary, Chen, Zhuo Zhen, primary, Tucholska, Monika, primary, Norzin, Tenzin, primary, Ho, Margaret Truc, primary, Phan, Morla, primary, Mohamed, Nargiz, primary, Ravandi, Amir, primary, Stanton, Eric, primary, Slutsky, Arthur S., primary, dos Santos, Claudia C., primary, Romaschin, Alexander, primary, Marshall, John C., primary, Addison, Christina, primary, Malone, Shawn, primary, Heyland, Daren, primary, Scheltens, Philip, primary, Killestein, Joep, primary, Teunissen, Charlotte E., primary, Diamandis, Eleftherios P., primary, Siu, K. W. Michael, primary, and Marshall, John G., primary

Published
2022
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8. The plasma peptides of ovarian cancer

Author

Dufresne, Jaimie, primary, Bowden, Pete, primary, Thavarajah, Thanusi, primary, Florentinus-Mefailoski, Angelique, primary, Chen, Zhuo Zhen, primary, Tucholska, Monika, primary, Norzin, Tenzin, primary, Ho, Margaret Truc, primary, Phan, Morla, primary, Mohamed, Nargiz, primary, Ravandi, Amir, primary, Stanton, Eric, primary, Slutsky, Arthur S., primary, dos Santos, Claudia C., primary, Romaschin, Alexander, primary, Marshall, John C., primary, Addison, Christina, primary, Malone, Shawn, primary, Heyland, Daren, primary, Scheltens, Philip, primary, Killestein, Joep, primary, Teunissen, Charlotte E., primary, Diamandis, Eleftherios P., primary, Siu, K. W. Michael, primary, and Marshall, John G., primary

Published
2021
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9. Plasma Peptidome

Author

Dufresne, Jaimie, primary, Bowden, Pete, primary, Thavarajah, Thanusi, primary, Florentinus-Mefailoski, Angelique, primary, Chen, Zhuo Zhen, primary, Tucholska, Monika, primary, Norzin, Tenzin, primary, Ho, Margaret Truc, primary, Phan, Morla, primary, Mohamed, Nargiz, primary, Ravandi, Amir, primary, Stanton, Eric, primary, Slutsky, Arthur S., primary, dos Santos, Claudia C., primary, Romaschin, Alexander, primary, Marshall, John C., primary, Addison, Christina, primary, Malone, Shawn, primary, Heyland, Daren, primary, Scheltens, Philip, primary, Killestein, Joep, primary, Teunissen, Charlotte E., primary, Diamandis, Eleftherios P., primary, Siu, K. W. Michael, primary, and Marshall, John G., primary

Published
2021
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10. Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions

Author

Müller, Paul M, Rademacher, Juliane, Bagshaw, Richard D, Wortmann, Celina, Barth, Carolin, van Unen, Jakobus, Alp, Keziban M, Giudice, Girolamo, Eccles, Rebecca L, Heinrich, Louise E, Pascual-Vargas, Patricia, Sanchez-Castro, Marta, Brandenburg, Lennart, Mbamalu, Geraldine, Tucholska, Monika, Spatt, Lisa, Czajkowski, Maciej T, Welke, Robert-William, Zhang, Sunqu, Nguyen, Vivian, Rrustemi, Trendelina, Trnka, Philipp, Freitag, Kiara, Larsen, Brett, Popp, Oliver, Mertins, Philipp, Gingras, Anne-Claude, Roth, Frederick P, Colwill, Karen, Bakal, Chris, Pertz, Olivier, Pawson, Tony, Petsalaki, Evangelia, and Rocks, Oliver

Subjects
rac1 GTP-Binding Protein, Integrins, Pan troglodytes, Mechanotransduction, Cellular, Cell Line, Madin Darby Canine Kidney Cells, Mice, Dogs, Protein Domains, Cell Movement, Chlorocebus aethiops, Cell Adhesion, Animals, Humans, Cytoskeleton, Gene Expression Profiling, GTPase-Activating Proteins, Computational Biology, Fibroblasts, Rats, HEK293 Cells, Gene Expression Regulation, COS Cells, 570 Life sciences, biology, Rho Guanine Nucleotide Exchange Factors, HeLa Cells
Abstract

Rho GTPases are central regulators of the cytoskeleton and, in humans, are controlled by 145 multidomain guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins (RhoGAPs). How Rho signalling patterns are established in dynamic cell spaces to control cellular morphogenesis is unclear. Through a family-wide characterization of substrate specificities, interactomes and localization, we reveal at the systems level how RhoGEFs and RhoGAPs contextualize and spatiotemporally control Rho signalling. These proteins are widely autoinhibited to allow local regulation, form complexes to jointly coordinate their networks and provide positional information for signalling. RhoGAPs are more promiscuous than RhoGEFs to confine Rho activity gradients. Our resource enabled us to uncover a multi-RhoGEF complex downstream of G-protein-coupled receptors controlling CDC42-RHOA crosstalk. Moreover, we show that integrin adhesions spatially segregate GEFs and GAPs to shape RAC1 activity zones in response to mechanical cues. This mechanism controls the protrusion and contraction dynamics fundamental to cell motility. Our systems analysis of Rho regulators is key to revealing emergent organization principles of Rho signalling.

Published
2020
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14. The plasma peptidome 03 Chemical Sciences 0301 Analytical Chemistry

Author

Dufresne, Jaimie, Bowden, Pete, Thavarajah, Thanusi, Florentinus-Mefailoski, Angelique, Chen, Zhuo Zhen, Tucholska, Monika, Norzin, Tenzin, Ho, Margaret Truc, Phan, Morla, Mohamed, Nargiz, Ravandi, Amir, Stanton, Eric, Slutsky, Arthur S., Dos Santos, Claudia C., Romaschin, Alexander, Marshall, John C., Addison, Christina, Malone, Shawn, Heyland, Daren, Scheltens, Philip, Killestein, Joep, Teunissen, Charlotte, Diamandis, Eleftherios P., Siu, K. W.M., Marshall, John G., Neurology, Amsterdam Neuroscience - Neurodegeneration, Amsterdam Neuroscience - Neuroinfection & -inflammation, Clinical chemistry, and CCA - Imaging and biomarkers

Abstract

Background: It may be possible to discover new diagnostic or therapeutic peptides or proteins from blood plasma using LC-ESI-MS/MS to identify, with a linear quadrupole ion trap to identify, quantify and compare the statistical distributions of peptides cleaved ex vivo from plasma samples from different clinical populations. Methods: A systematic method for the organic fractionation of plasma peptides was applied to identify and quantify the endogenous tryptic peptides from human plasma from multiple institutions by C18 HPLC followed nano electrospray ionization and tandem mass spectrometry (LC-ESI-MS/MS) with a linear quadrupole ion trap. The endogenous tryptic peptides, or tryptic phospho peptides (i.e. without exogenous digestion), were extracted in a mixture of organic solvent and water, dried and collected by preparative C18. The tryptic peptides from 6 institutions with 12 different disease and normal EDTA plasma populations, alongside ice cold controls for pre-analytical variation, were characterized by mass spectrometry. Each patient plasma was precipitated in 90% acetonitrile and the endogenous tryptic peptides extracted by a stepwise gradient of increasing water and then formic acid resulting in 10 sub-fractions. The fractionated peptides were manually collected over preparative C18 and injected for 1508 LC-ESI-MS/MS experiments analyzed in SQL Server R. Results: Peptides that were cleaved in human plasma by a tryptic activity ex vivo provided convenient and sensitive access to most human proteins in plasma that show differences in the frequency or intensity of proteins observed across populations that may have clinical significance. Combination of step wise organic extraction of 200 μL of plasma with nano electrospray resulted in the confident identification and quantification ~ 14,000 gene symbols by X!TANDEM that is the largest number of blood proteins identified to date and shows that you can monitor the ex vivo proteolysis of most human proteins, including interleukins, from blood. A total of 15,968,550 MS/MS spectra ≥ E4 intensity counts were correlated by the SEQUEST and X!TANDEM algorithms to a federated library of 157,478 protein sequences that were filtered for best charge state (2+ or 3+) and peptide sequence in SQL Server resulting in 1,916,672 distinct best-fit peptide correlations for analysis with the R statistical system. SEQUEST identified some 140,054 protein accessions, or some ~ 26,000 gene symbols, proteins or loci, with at least 5 independent correlations. The X!TANDEM algorithm made at least 5 best fit correlations to more than 14,000 protein gene symbols with p-values and FDR corrected q-values of ~ 0.001 or less. Log10 peptide intensity values showed a Gaussian distribution from E8 to E4 arbitrary counts by quantile plot, and significant variation in average precursor intensity across the disease and controls treatments by ANOVA with means compared by the Tukey-Kramer test. STRING analysis of the top 2000 gene symbols showed a tight association of cellular proteins that were apparently present in the plasma as protein complexes with related cellular components, molecular functions and biological processes. Conclusions: The random and independent sampling of pre-fractionated blood peptides by LC-ESI-MS/MS with SQL Server-R analysis revealed the largest plasma proteome to date and was a practical method to quantify and compare the frequency or log10 intensity of individual proteins cleaved ex vivo across populations of plasma samples from multiple clinical locations to discover treatment-specific variation using classical statistics suitable for clinical science. It was possible to identify and quantify nearly all human proteins from EDTA plasma and compare the results of thousands of LC-ESI-MS/MS experiments from multiple clinical populations using standard database methods in SQL Server and classical statistical strategies in the R data analysis system.

Published
2018

15. Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains

Author

Lambert, Jean-Philippe, Picaud, Sarah, Fujisawa, Takao, Hou, Huayun, Savitsky, Pavel, Uusküla-Reimand, Liis, Gupta, Gagan D, Abdouni, Hala, Lin, Zhen-Yuan, Tucholska, Monika, Knight, James D R, Gonzalez-Badillo, Beatriz, St-Denis, Nicole, Newman, Joseph A, Stucki, Manuel, Pelletier, Laurence, Bandeira, Nuno, Wilson, Michael D, Filippakopoulos, Panagis, Gingras, Anne-Claude, Lambert, Jean-Philippe, Picaud, Sarah, Fujisawa, Takao, Hou, Huayun, Savitsky, Pavel, Uusküla-Reimand, Liis, Gupta, Gagan D, Abdouni, Hala, Lin, Zhen-Yuan, Tucholska, Monika, Knight, James D R, Gonzalez-Badillo, Beatriz, St-Denis, Nicole, Newman, Joseph A, Stucki, Manuel, Pelletier, Laurence, Bandeira, Nuno, Wilson, Michael D, Filippakopoulos, Panagis, and Gingras, Anne-Claude

Abstract

Targeting bromodomains (BRDs) of the bromo-and-extra-terminal (BET) family offers opportunities for therapeutic intervention in cancer and other diseases. Here, we profile the interactomes of BRD2, BRD3, BRD4, and BRDT following treatment with the pan-BET BRD inhibitor JQ1, revealing broad rewiring of the interaction landscape, with three distinct classes of behavior for the 603 unique interactors identified. A group of proteins associate in a JQ1-sensitive manner with BET BRDs through canonical and new binding modes, while two classes of extra-terminal (ET)-domain binding motifs mediate acetylation-independent interactions. Last, we identify an unexpected increase in several interactions following JQ1 treatment that define negative functions for BRD3 in the regulation of rRNA synthesis and potentially RNAPII-dependent gene expression that result in decreased cell proliferation. Together, our data highlight the contributions of BET protein modules to their interactomes allowing for a better understanding of pharmacological rewiring in response to JQ1.

Published
2019

16. Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains

Author

Lambert, Jean-Philippe, primary, Picaud, Sarah, additional, Fujisawa, Takao, additional, Hou, Huayun, additional, Savitsky, Pavel, additional, Uusküla-Reimand, Liis, additional, Gupta, Gagan D., additional, Abdouni, Hala, additional, Lin, Zhen-Yuan, additional, Tucholska, Monika, additional, Knight, James D.R., additional, Gonzalez-Badillo, Beatriz, additional, St-Denis, Nicole, additional, Newman, Joseph A., additional, Stucki, Manuel, additional, Pelletier, Laurence, additional, Bandeira, Nuno, additional, Wilson, Michael D., additional, Filippakopoulos, Panagis, additional, and Gingras, Anne-Claude, additional

Published
2019
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17. The plasma peptides of ovarian cancer

Author

Dufresne, Jaimie, primary, Bowden, Pete, additional, Thavarajah, Thanusi, additional, Florentinus-Mefailoski, Angelique, additional, Chen, Zhuo Zhen, additional, Tucholska, Monika, additional, Norzin, Tenzin, additional, Ho, Margaret Truc, additional, Phan, Morla, additional, Mohamed, Nargiz, additional, Ravandi, Amir, additional, Stanton, Eric, additional, Slutsky, Arthur S., additional, dos Santos, Claudia C., additional, Romaschin, Alexander, additional, Marshall, John C., additional, Addison, Christina, additional, Malone, Shawn, additional, Heyland, Daren, additional, Scheltens, Philip, additional, Killestein, Joep, additional, Teunissen, Charlotte E., additional, Diamandis, Eleftherios P., additional, Michael Siu, K. W., additional, and Marshall, John G., additional

Published
2018
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18. Spatial Organization of Rho GTPase signaling by RhoGEF/RhoGAP proteins

Author

Müller, Paul M., primary, Rademacher, Juliane, additional, Bagshaw, Richard D., additional, Alp, Keziban M., additional, Giudice, Girolamo, additional, Heinrich, Louise E., additional, Barth, Carolin, additional, Eccles, Rebecca L., additional, Sanchez-Castro, Marta, additional, Brandenburg, Lennart, additional, Mbamalu, Geraldine, additional, Tucholska, Monika, additional, Spatt, Lisa, additional, Wortmann, Celina, additional, Czajkowski, Maciej T., additional, Welke, Robert-William, additional, Zhang, Sunqu, additional, Nguyen, Vivian, additional, Rrustemi, Trendelina, additional, Trnka, Philipp, additional, Freitag, Kiara, additional, Larsen, Brett, additional, Popp, Oliver, additional, Mertins, Philipp, additional, Bakal, Chris, additional, Gingras, Anne-Claude, additional, Pertz, Olivier, additional, Roth, Frederick P., additional, Colwill, Karen, additional, Pawson, Tony, additional, Petsalaki, Evangelia, additional, and Rocks, Oliver, additional

Published
2018
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19. Evolution of AF6-RAS association and its implications in mixed-lineage leukemia

Author

Smith, Matthew J., primary, Ottoni, Elizabeth, additional, Ishiyama, Noboru, additional, Goudreault, Marilyn, additional, Haman, André, additional, Meyer, Claus, additional, Tucholska, Monika, additional, Gasmi-Seabrook, Genevieve, additional, Menezes, Serena, additional, Laister, Rob C., additional, Minden, Mark D., additional, Marschalek, Rolf, additional, Gingras, Anne-Claude, additional, Hoang, Trang, additional, and Ikura, Mitsuhiko, additional

Published
2017
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25. Albumin Decrease Is Associated with Spontaneous Preterm Delivery within 48 h in Women with Threatened Preterm Labor

Author

Heng, Yujing J., primary, Taylor, Lorne, additional, Larsen, Brett G., additional, Chua, Hon Nian, additional, Pung, Soke May, additional, Lee, Mary W. F., additional, Tucholska, Monika, additional, Tate, Stephen, additional, Kupchak, Peter, additional, Pennell, Craig E., additional, Pawson, Tony, additional, and Lye, Stephen J., additional

Published
2014
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26. Directed Network Wiring Identifies a Key Protein Interaction in Embryonic Stem Cell Differentiation

Author

Yasui, Norihisa, primary, Findlay, Greg M., additional, Gish, Gerald D., additional, Hsiung, Marilyn S., additional, Huang, Jin, additional, Tucholska, Monika, additional, Taylor, Lorne, additional, Smith, Louis, additional, Boldridge, W. Clifford, additional, Koide, Akiko, additional, Pawson, Tony, additional, and Koide, Shohei, additional

Published
2014
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27. Soluble FLT1 binds lipid microdomains in podocytes to control cell morphology and glomerular barrier function

Author

Jin, Jing, Sison, Karen, Li, Chengjin, Tian, Ruijun, Wnuk, Monika, Sung, Hoon-Ki, Jeansson, Marie, Zhang, Cunjie, Tucholska, Monika, Jones, Nina, Kerjaschki, Dontscho, Shibuya, Masabumi, Fantus, I George, Nagy, Andras, Gerber, Hans-Peter, Ferrara, Napoleone, Pawson, Tony, Quaggin, Susan E, Jin, Jing, Sison, Karen, Li, Chengjin, Tian, Ruijun, Wnuk, Monika, Sung, Hoon-Ki, Jeansson, Marie, Zhang, Cunjie, Tucholska, Monika, Jones, Nina, Kerjaschki, Dontscho, Shibuya, Masabumi, Fantus, I George, Nagy, Andras, Gerber, Hans-Peter, Ferrara, Napoleone, Pawson, Tony, and Quaggin, Susan E

Abstract

Vascular endothelial growth factor and its receptors, FLK1/KDR and FLT1, are key regulators of angiogenesis. Unlike FLK1/KDR, the role of FLT1 has remained elusive. FLT1 is produced as soluble (sFLT1) and full-length isoforms. Here, we show that pericytes from multiple tissues produce sFLT1. To define the biologic role of sFLT1, we chose the glomerular microvasculature as a model system. Deletion of Flt1 from specialized glomerular pericytes, known as podocytes, causes reorganization of their cytoskeleton with massive proteinuria and kidney failure, characteristic features of nephrotic syndrome in humans. The kinase-deficient allele of Flt1 rescues this phenotype, demonstrating dispensability of the full-length isoform. Using cell imaging, proteomics, and lipidomics, we show that sFLT1 binds to the glycosphingolipid GM3 in lipid rafts on the surface of podocytes, promoting adhesion and rapid actin reorganization. sFLT1 also regulates pericyte function in vessels outside of the kidney. Our findings demonstrate an autocrine function for sFLT1 to control pericyte behavior.

Published
2012
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28. Interaction Domains of Sos1/Grb2 Are Finely Tuned for Cooperative Control of Embryonic Stem Cell Fate

Author

Findlay, Greg M., primary, Smith, Matthew J., additional, Lanner, Fredrik, additional, Hsiung, Marilyn S., additional, Gish, Gerald D., additional, Petsalaki, Evangelia, additional, Cockburn, Katie, additional, Kaneko, Tomonori, additional, Huang, Haiming, additional, Bagshaw, Richard D., additional, Ketela, Troy, additional, Tucholska, Monika, additional, Taylor, Lorne, additional, Bowtell, David D., additional, Moffat, Jason, additional, Ikura, Mitsuhiko, additional, Li, Shawn S.C., additional, Sidhu, Sachdev S., additional, Rossant, Janet, additional, and Pawson, Tony, additional

Published
2013
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29. Soluble FLT1 Binds Lipid Microdomains in Podocytes to Control Cell Morphology and Glomerular Barrier Function

Author

Jin, Jing, primary, Sison, Karen, additional, Li, Chengjin, additional, Tian, Ruijun, additional, Wnuk, Monika, additional, Sung, Hoon-Ki, additional, Jeansson, Marie, additional, Zhang, Cunjie, additional, Tucholska, Monika, additional, Jones, Nina, additional, Kerjaschki, Dontscho, additional, Shibuya, Masabumi, additional, Fantus, I. George, additional, Nagy, Andras, additional, Gerber, Hans-Peter, additional, Ferrara, Napoleone, additional, Pawson, Tony, additional, and Quaggin, Susan E., additional

Published
2012
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33. Albumin Decrease Is Associated with Spontaneous Preterm Delivery within 48 h in Women with Threatened Preterm Labor

Author

Heng, Yujing J., Taylor, Lorne, Larsen, Brett G., Chua, Hon Nian, Pung, Soke May, Lee, Mary W. F., Tucholska, Monika, Tate, Stephen, Kupchak, Peter, Pennell, Craig E., Pawson, Tony, and Lye, Stephen J.

Abstract

Threatened preterm labor (TPTL) accounts for ∼30% of pregnancy-related hospital admissions. Maternal peripheral leukocytes can be used to monitor a variety of physiological processes occurring in the body. Two high-throughput mass spectrometry methodologies, SWATH and iTRAQ, were used to study differentially expressed peripheral blood leukocyte lysate proteins in symptomatic women admitted for TPTL who had a preterm birth within 48 h (n= 16) and those who did not (n= 24). The SWATH spectral library consisted of 783 proteins. SWATH methodology quantified 258 proteins (using ≥2 peptides) and 5 proteins (ALBU, ANXA6, HNRPK, HSP90A, and PDIA1) were differentially expressed (p< 0.05, Mann–Whitney U). iTRAQ workflow identified 765 proteins; 354 proteins were quantified and 14 proteins (MIF, UBIQ, HXK3, ALBU, HNRPD, ST1A2, RS15A, RAP1B, CAN1, IQGA2, ST1A1, COX5A, ADDA, and UBQL1) were significantly different between the two groups of women (p< 0.05, Mann–Whitney U). Albumin was the only common differentially expressed protein in both SWATH (28% decrease) and iTRAQ studies (45% decrease). This decrease in albumin was validated using ELISA (11% decrease, p< 0.05, Mann–Whitney U) in another 23 TPTL women. This work suggests that albumin is a broad indicator of leukocyte activation with impending preterm birth and provides new future work directions to understand the pathophysiology of TPTL.

Published
2015
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34. MOESM1 of The plasma peptides of ovarian cancer

Author

Dufresne, Jaimie, Bowden, Pete, Thanusi Thavarajah, Florentinus-Mefailoski, Angelique, Chen, Zhuo, Tucholska, Monika, Tenzin Norzin, Ho, Margaret, Morla Phan, Mohamed, Nargiz, Ravandi, Amir, Stanton, Eric, Slutsky, Arthur, Santos, Claudia, Romaschin, Alexander, Marshall, John, Addison, Christina, Malone, Shawn, Heyland, Daren, Scheltens, Philip, Killestein, Joep, Teunissen, Charlotte, Diamandis, Eleftherios, and K. Michael Siu

Subjects
3. Good health
Abstract

Additional file 1: Table S1 The number of successful LC-ESI-MS/MS experiments that resulted in successful correlations to peptides from the various disease and normal treatments.

35. MOESM1 of The plasma peptides of ovarian cancer

Author

Dufresne, Jaimie, Bowden, Pete, Thanusi Thavarajah, Florentinus-Mefailoski, Angelique, Chen, Zhuo, Tucholska, Monika, Tenzin Norzin, Ho, Margaret, Morla Phan, Mohamed, Nargiz, Ravandi, Amir, Stanton, Eric, Slutsky, Arthur, Santos, Claudia, Romaschin, Alexander, Marshall, John, Addison, Christina, Malone, Shawn, Heyland, Daren, Scheltens, Philip, Killestein, Joep, Teunissen, Charlotte, Diamandis, Eleftherios, and K. Michael Siu

Subjects
3. Good health
Abstract

Additional file 1: Table S1 The number of successful LC-ESI-MS/MS experiments that resulted in successful correlations to peptides from the various disease and normal treatments.

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