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2,164 results on '"Tucker, David"'

1. Conclusion

Author

Tucker, David

Published
2016

3. 4 Retreat

Author

Tucker, David

Published
2016

6. 1 Conquest

Author

Tucker, David

Published
2016

7. Index

Author

Tucker, David

Published
2016

8. References

Author

Tucker, David

Published
2016

11. Surveillance of multiple congenital anomalies; searching for new associations

Author

Morris, Joan K., Bergman, Jorieke E. H., Barisic, Ingeborg, Wellesley, Diana, Tucker, David, Limb, Elizabeth, Addor, Marie-Claude, Cavero-Carbonell, Clara, Matias Dias, Carlos, Draper, Elisabeth S., Echevarría-González-de-Garibay, Luis Javier, Gatt, Miriam, Klungsøyr, Kari, Lelong, Nathalie, Luyt, Karen, Materna-Kiryluk, Anna, Nelen, Vera, Neville, Amanda, Perthus, Isabelle, Pierini, Anna, Randrianaivo-Ranjatoelina, Hanitra, Rankin, Judith, Rissmann, Anke, Rouget, Florence, Sayers, Geraldine, Wertelecki, Wladimir, Kinsner-Ovaskainen, Agnieszka, and Garne, Ester

Published
2024
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12. Tranexamic acid versus placebo to prevent bleeding in patients with haematological malignancies and severe thrombocytopenia (TREATT): a randomised, double-blind, parallel, phase 3 superiority trial

Author

Estcourt, Lise J, McQuilten, Zoe K, Bardy, Peter, Cole-Sinclair, Merrole, Collins, Graham P., Crispin, Philip J., Curnow, Elinor, Curnow, Jennifer, Degelia, Amber, Dyer, Claire, Friebe, Adam, Floro, Lajos, Grand, Effie, Hudson, Cara, Jones, Gail, Joseph, Joanne, Kallmeyer, Charlotte, Karakantza, Marina, Kerr, Paul, Last, Sara, Lobo-Clarke, Maria, Lumley, Matthew, McMullin, Mary F, Medd, Patrick G., Morton, Suzy M., Mumford, Andrew D., Mushkbar, Maria, Parsons, Joseph, Powter, Gillian, Sekhar, Mallika, Smith, Laura, Soutar, Richard, Stevenson, William S., Subramoniapillai, Elango, Szer, Jeff, Thomas, Helen, Waters, Neil A., Wei, Andrew H., Westerman, David A., Wexler, Sarah A., Wood, Erica M., Stanworth, Simon J., Abioye, Adrienne, Afghan, Rabia, Ai, Sylvia Ai, Akanni, Magbor, Alajangi, Rajesh, Alam, Usmaan, Al-Bubseeree, Bahaa, Alderson, Sophie, Alderson, Craig, Ali, Sayed, Ali, Kabir, Alighan, Rookmeen, Allam, Rebecca Allam, Allen, Tania, Al-Sakkaf, Wesam, Ames, Kate, Anderson, Jacqueline, Andrews, Colin, Angel, Ann-Marie, Anlya, Manuela Anlya, Ansari, Farah, Appleby, Rowan, Arnold, Claire, Asbjornsdottir, Hulda, Asfaw, Biruk, Atkins, Elissa, Atkinson, Leela, Aubrey, Clare, Ayesha, Noor, Babbola, Lola, Badcock, David, Badcock, Samuel, Baggio, Diva, Bailiff, Ben, Baines, Kizzy, Baker, Holly, Baker, Victoria, Ball, Lindsay, Ball, Martin, Balquin, Irwin, Banks, Emma, Banos, George, Barnett, Jaytee, Barrie, Claire, Barron, Claire, Barton, Rebecca, Bason, Nina, Batta, Bindu, Bautista, Dianne, Bayley, Angela, Bayly, Emma, Baynes, Fionnuala, Bazargan, Ali, Bazeley, Rachel, Beadle, Yvonne, Beardsmore, Claire, Beattie, Kate, Bedford, Caroline, Behal, Rachna, Behan, Daniel, Bejan, Lilihna, Bell, Sarah, Bell, Karen, Bell, Louise, Bell, Kaitlyn, Benjamin, Reuben, Bennett, Sam, Benson, Gary, Benson, Warwick, Bent, Cameron, Bergin, Krystal, Berry, Alex, Besenyei, Stephanie, Besley, Caroline, Betteridge, Scott, Beveridge, Leigh, Bhattacharyya, Abir, Billen, Annelies, Bilmon, Ian, Binns, Emma, Birt, Mark, Bishop, David, Blanco, Andrea, Bleby, Lisa, Blemnerhet, Richard, Blombery, Piers, Blyth, Emily, Blythe, Nicola, Boal, Lauren, Boden, Ali, Bokhari, Syed W.I., Bongetti, Elisa, Booth, Stephen, Borley, Jayne, Bowen, David, Bowers, Dawn, Boyd, Stephen, Bradley, Sarah, Bradman, Helen, Bretag, Peta, Brillante, Maria, Brockbank, Rachel, Brough, Yasmin, Brown, Ellen, Brown, Jo, Brown, Eleanor, Brown, Claire, Brown, Jenny, Brown, Susan, Browning, Joe, Brownsdon, Alex, Bruce, David, Brydon-Hill, Ruth, Buckwell, Andrea, Burgess, Dannielle, Burke, Glenda, Burley, Kate, Burney, Claire, Burns, David, Burrows, Samuel, burton, Kieran, Butler, Jason, Cambalova, Lenka, Camozzi, Maria C., Campbell, Philip, Campfield, Karen, Campion, Victoria, Cargo, Catherine, Carmona, Julia, Carney, Dennis, Casan, Joshua, Cashman, Helen, Catt, Lorraine, Cattell, Michael, Cavill, Megan, Chadbone, Rachel, Chaganti, Sridhar, Chai, Yee, Chai, Khai Li, Chang, Joshua, Chapman, Judith, Chapman, Oliver G., Chapter, Tamika, Charlton, Andrew, Chau, Celina, Chauhan, Saleena, Chavda, Nikesh, Chen, Frederick, Chen, Melody, Chen, Meng Xi, Chen, Melanie, Chen, Melissa, Cheok, Kathleen, Cheung, Mai, Chidgey, Luke, Chmielokliec, Karolina, Choi, Philip, Choi, Jae, Chok, Anne, Chopra, Ruchika, Christopherson, Louise, Chu, Vicky, Chua, Chong Chyn, Chudakou, Pavel, Chugh, Vidushi, Chung, Chi, Clark, Erin, Clarke, Peter, Clarke, Kathleen, Clay, Jennifer, Clayton, Laura, Clements, Mitch, Clemmens, Jonathan, Clifford, Ruth, Collett, Dave, Collins, Maia, Collyer, Emily, Connolly, Maureen, Cook, Mark, Coombs, Sarah, Coppell, Jason, Cornwell, Sophie, Corrigan, Claire, Coughlin, Elizabeth, Couling, Jennifer, Cousins, Tony, Cowan, Catriona, Cox, Christine, Cox, Catherine, Coyle, Luke, Craig, Emily, Creasey, Thomas, Croan, Laura, Croft, Jane, Crosbie, Nicola, Crowe, Josephine, Crowther, Helen, Crozier, Jane, Culleton, Naomi, Cullis, Jonathan, Cumming, Anita, Cummins, Michelle, Cunningham, Adam, Curley, Cameron, Curtis, Samantha, Cuthbert, Robert, Cuthill, Kirsty, Dahahayake, Dinusha A, Dang, Amy, Davies, Marc, Davies, Ceri, Dawson, Emily, Day, Tom, De Abrew, Kanchana, De Lavallade, Hugues, De Silva, Neelaskshi, Dean, Georgina, Deane, Christopher, Demosthenous, Lisa, Desai, Amisha, Desborough, Michael, Devanny, Ian, Dhanapal, Jay, Dhani, Sundip, Di Martino, Vicky, Dickens, Emmy, DiCorleto, Carmen, Dinnett, Louise, Dirisan, Divya, Dixon, Karen, Dixon, Kiri, Doal, Inderjit, Dobivh, J, Docanto, Maria, Doecke, Helve, Donaldson, David, Donaldson, Kylee, Donohoe, Carrie, Douglas, Ashley, Doung, Stephen, Downer, Susan, D'Rozario, James, Drummond, Malcolm, Drummond, Mark, Drummond, Samantha, Drysdale, Elizabeth, D'Souza, Ross, D'Souza, Eugene, Dunn, Alex, Dutton, David, Dyson, Martin, Ediriwicurena, Kushani, Edleston, Sharon, Edwards, Dawn, Edwards, Morgan, Edwards, Anita, Eise, Nicole, Ellis, Steven, Ellis, Hayley, Elmonley, Shareef, Enstone, Rosemarie, Eordogh, Agnes, Erb, Sharon, Evans, Shannon, Evans, Megan, Ewing, Joanne, Eyre, Toby, Facey, Adam, Fammy, Mina, Farman, Jon, Farnell, Rachel, Favero, Laura, Fay, Keith, Ferguson, Karen, Fernon, Laura, Filshie, Robin, Finnegan, Damian, Fisher, Lisa, Flanagan, Asia, Fleck, Emma, Fletcher, Simon, Flora, Harpreet, Flower, Catherine, Fodor, Ioana, Foley, Heather, Folland, Emma, Folorunso, Comfort, Forbes, Molly, Fordwor, Katrina, Foster, Polly, Fox, Vanessa, Fox, Thomas, Francis, Olesya, Fryearson, Louise, Fuery, Madonna, Fung, Jiin, Furtado, Michelle, Galloway-Browne, Leanne, Gamble, Louise, Gamgee, Jeanette, Ganapathy, Arundathi, Gardner, Hayley, Gardner, Clare, Gasmelsheed, Noha, Gately, Amy, Gaynor, Lynda, Gebreid, Alex, Geffens, Ruth, George, Rachel, Gertner, Aniko, Ghebeh, Manar, Ghirardini, Emanuela, Giddings, Melainie, Gillett, Sandra, Gillett, Karen, Giri, Pratyush, Glass, Chris, Glewis, Sarah, Gooding, Sarah, Gordon, Olivia, Gordon, Joanne, Gottlieb, David, Gowda, Koushik, Gower, Elysie, Gray, Nicola, Grayer, Jo, Greaves, Elaine, Greenaway, Sally Anne, Greenfield, Graeme, Greenwood, Matthew, Gregory, Gareth, Griffin, James, Griffith, Julia, Griffith, James, Griffiths, Lindsey, Grzegrzolka, Paulina, Gu, Yisu, Guest, Jo, Guinai, Rosanna, Gullapalli, Veena, Gunolr, A., Guo, Lina, H, Wayne, Hagua, Sophia, Haile, Senait, Hall, Richard, Hamdollah-Zadeh, Maryam, Hanif, Zahra, Hanlon, Kathleen, Hann, Nicholas, Hanna, Ramez, Hannah, Guy, Hapuarachchi, Sameera, Hardman, Jacinta, Hardy, Alison, Harris, Anthony, Harris, Kylie, Harrison, Beth, Harrison, Simon, Harrison, Lea-Anne, Harrop, Sean, Harvey, Caroline, Hatcliffe, Faye, Hawking, Jo, Hawkins, Matthew, Hayden, Janet, Hayman, Michelle, Haynes, Elizabeth, Heaney, Nicholas, Hebbard, Andrew, Hempton, Jenny, Hendunneti, Sasanka, Henry, Maeve, Heywood, Jonathan, Hildyard, Catherine, Hill, Lydia, Hilldrith, Annette, Hitev, Petar, Hiwase, Smita, Hiwase, Devendra, Hoare, Chris, Hodge, Renate, Holloway, Amy, Holt, Chloe, Holton, Kelly, Homer, Lauren, Horne, Gillian, Horvath, Noemi, Hotong, Linda, Houdyk, Kristen, Houseman, Katy, Hoxhallari, Ilda, Hsu, Hannah, Hsu, Nina, Huang, Gillian, Hudson, Kerryn, Hufton, Melanie, Hughes, Timothy, Hughes, Siobhan, Hurley, Kate, Huxley, Rosie, Ibitoye, Temitope, Ibrouf, Abubaken, Inam, Farha, Indran, Tishya, Ingham, Karen, Innes, Calum, Irvine, David, Jaafar, Sarah, Jain, Manish, Jameson, Laura, Janjua, Pardeep, Jarvis, Rebecca, Jatheendran, Abirami, Javed, Abbie, Jen, Sheila, Jobanpura, Shailesh, Jobson, Irene, John, Deborah, Johns, Sophie, Johnston, Amanda, Jones, Hollie, Jones, Francesca, Joniak, Karolina, Jovanovic, Michael, Jovic, Anita, Joyce, Lauren, Judd, Andrew, Kakarlamudi, Sudhakar, Kakaroubas, Nick, Kalita, Maggie, Kam, Shirly, Kan, Julie, Kandle, P, Kanellopoulos, Alex, Kao, Chien, Kaparou, Maria, Kartsios, Charamlampos, Katsioulas, Vicki, Kaye, Russell, Keen, Katie, Kelly, Richard, Kelly, Pauline, Kelly, Donna, Kelly, Melanie, Kennedy, Glen, Kennedy, Nola, Kenny, Angela, Kenworthy, Zoe, Kerridge, Ian, Kesavan, Murali, Khafizi, Angelika, Khakwani, Muhammad, Khalid, Amna, Khamly, Kate, Khan, Anjum, Khan, Dalia, Khan, Mojid, Khan, Lubna, Khoo, Mona, Khwaja, Asim, Kim, Grace, King, Andrew, King, Vicky, King, Donna, Kinsella, Francesca, Kipp, David, Kirandeep, Pachoo, Kirui, Laura C., Kishore, Bhuvan, Knectlhi, Christopher, Knot, Amy, Knot, Armit, Ko, Cathy, Kolaric, Caitlin, Koo, Ray, Kotadia, Mary, Kothari, Jaimal, Kottaridis, Panagiotis D., Kuiluinathan, Gajan, Kulasekararaj, Austin, Kwan, John, Kwok, Marwan, Kwok, Phillip, Kwok, Fiona, Laane, Kristiina, Lad, Deena, Laird, Jennifer, Lam, Ada, Lane, Mary, Lanenco, Monica, Lang, Susan, Langridge, Alex, Langton, Catherine, Lannon, Michelle, Latif, Annie, Latimer, Maya, Latter, Ruth, Lau, I-Jun, Lawless, Sarah, Lawless, Theresa, Leach, Mike, Leaney, Sarah, Leary, Heather, Leavy, James, LeBlanc, Abbey, Lee, Vivienne, Lee, Edwin, Lee, Jenny, Lee, Tamara, Leischkie, Marian, Leitinger, Emma, Leon, Christopher, Leonard, Jayne, Lewis, David, Lewis, Ian, Lewis, Tania, Lim, Daniel, Littlewood, Kelly, Liu, Dara, Loh, Joanna, Lokare, Anand, Lomas, Oliver, Lovell, Richard, Lowe, Theresa, Lowry, Lisa, Lubowiecki, Marcin, Lumb, Rebecca, Lynch, Gail, Macaulay, Amanda, MacDonald, Lyndsey, MacDonald-Burn, Jill, Macmillan, Margaret, Maddock, Karen, Mahaliyana, Tomas, Mahon, Cassandra, Maidment, Alison, Maier, Susie, Mairos, Michelle, Majid, Mahseeman, Mak, Ka L, Mak, Anne, Malendrayogau, Arunthrthy, Malham, Hana, Malyon, Felicity, Mandadapu, Vineela, Mandel, Laura, Mant, Sarah, Manton, Ruth, Maouche, Nadjoua, Maqbool, Muhammad G., Marchant, Gregory, Marinho, Mariana, Marks, David, Marner, Mike, Marr, Helen, Marshall, Gillian, Martin, Siobhan, Martin, Abigail, Marzolini, Maria, Mason, Kiara, Massie, Jonathan, Masson, Rebecca, Mathavan, Vidya, Mathew, Siju, Mathie, Judith, Mattocks, Lehenta, Maybury, Bernard, Mayer, Georgina, McAlister, Chyrelle, McAllister, Jo, McConnell, Stewart, McCracken, James, McCullagh, Liz, McCulloch, Rory, Mcdermott, Christopher, Mcdonald, Kerian, McGinniss, Laura, McGurk, Fiona, McIlwain, Jessica, McIver, Kirsten, Mckay, Pam, McKenna, Lorraine, Mclornan, Donal, McMahon, Coalon, McNeice, Linda, McNeill, Susan, McNickle, Molly, McQueen, Fiona, McRae, Simon, McTaggart, Bobby, Mehew, Jenny, Mehra, Varnn, Melly, Michelle, Menichelli, Tara, Micklethwatte, Ken, Mihailescue, Loredana, Mijovic, Aleksander, Millband, Hannah, Miller, Lucy, Millien, Samuel T., Milnthorpe, James, Minson, Adrian, Molnar, Eva, Monsour, Marc, Moody, Mary, Moon, Rebecca, Moore, Sally, Moore, Katy, Morgan, Kelly, Morralley, Rebecca, Morris, Denise, Morris, Kirk, Morrison, Nicole, Moss, Merinda, Mughal, Muhammad, Muir, Paul, Mukkath, David, Mulla, Aasiyu, Mulligan, Stephen, Mullings, Joanne, Mulqueen, Angela, Muluey, Caitlin, Murdoch, Sarah, Murrani, Sura, Murthy, Vidhya, Musngi, Jimmy, Mustafa, Nadreen, Mynes, Tracey, Nalpantidis, Anastasios, Nandurkar, Harshal, Nardone, Linda, Nasari, Latifa, Nash, Monica, Naylor, Georgina, Ngu, Loretta, Nguethina, Melissa, Nguyen, John, Nguyen, Joseph, Nichol, Wendy, Nicholls, Emma, Nicole, Catherine S., Nicolson, Phillip, Nielson, David, Nikolousis, Emmanouil, Nix, Georgina, Njoku, Rita, Norman, Jane, Norman, Amy, Norris, Phoebe, North, Daniel, Norwood, Megan, Notcheva, Gaynor, Novitzky-Basso, Igor, Nyaboko, Joseph, Nygren, Maria, Obu, Ingrid, O'Connell, Siobhan, O'Connor, Jody, O'Kelly, Deanna, O'Niell, Aideen, Ony, Jeremy, Oo, Kathy, Oo, April, Oppermann, Anne, Orr, Ruth, O'Sullivan, Mary, Page, Jennifer, Palfreyman, Emma, Paneesha, Shankaranarayana, Panicker, Shyam, Parbutt, Catherine, Parigi, Elesha, Paris, Gemma, Parker, Tracey, Parnell, Caroline, Parrish, Christopher, Parsons, Alex, Pasat, Mioara, Patel, Natasha, Patel, Vijay, Patel, Pooja, Patel, Chaya, Pati, Nalini, Patterson, Andrea, Paul, Lauren, Payet, Danielle, Payne, Elspeth, Peachey, Victoria, Pearson, Amanda, Peniket, Andy, Percy, Laura, Pereyra, Millicent, Pervaiz, Omer, Phalod, Gunjan D, Pham, Anh, Pho, Jason, Pickard, Keir, Pidcock, Michael, Piggin, Anna, Pishyar, Yalda, Pocock, Abigail, Pol, Ranjendres, Polzella, Paolo, Poolan, Sonia, Portingale, Vicki, Posnett, Claire, Potluri, Sandeep, Potter, Victoria, Pratt, Guy, Prodger, Catherine, Pueblo, Andres, Puliyayil, Anish, Puvanakumar, Pratheepan, Qadri, Abdul, Quach, Hang, Quinn, Michael, Rafferty, Mark, Rahman, Marzia, Raj, Kavita, Raj, Sonia, Rajendran, Ramina, Ramanan, Radha, Ramasamy, Karthik, Rampotas, Alexandros, Ranchhod, Natasha, Rashid, Sabia, Ratanjee, Sunita, Rathore, Gurpreet, Ratnasingam, Sumita, Rayat, Manjit, Rayner, Michael, Reddell-Denton, Rebecca, Redding, Nicola, Reddy, Udaya, Rehman, Atique, Rice, Carol, Riches, Iwona, Rider, Thomas, Riley, John, Rinaldi, Ciro, Roberts, Kayleigh, Roberts, Andrew, Robertson, Bryony, Robertson, Peter, Robinson, Dan, Robinson, Rebecca, Robjohns, Emma, Robledo, Laura, Rodrigues, Ana, Rofe, Chris, Roff, Bridie, Rogers, Rachel, Rolt, Jill, Rooney, Carmela, Rose, Kathy, Rose, Hannah, Ross, David, Rouf, Shahara, Rourke, Claire, Routledge, David, Ruggiero, Janet, Rule, Simon, Rumsey, Richard, Sagge, Cherry, Saldhana, Helen, Salisbury, Richard, Salisbury, Sarah, Salvaris, Ross, Sanders, Kay, Sangombe, Mirriam, Sanigorska, Anna, Santos, Kristine, Sarkis, Taylah, Sarma, Anita, Saunders, Natalie, Schmidt, Kara, Schmidtmann, Anja, Schumacher, Ann, Scorer, Tom Scorer, Scott, Asleigh, Seath, Ingrid, Sejman, Frances, Selim, Adrian, Shamim, Nadia, Shan, Jocelyn, Shanmuganathan, Naranie, Shanmugaranjan, Shaminie, Sharpe, Michelle, Sharpley, Faye, Shaw, Emma, Sheath, Cara, Sheehy, Oonagh, Shen, Vivian, Sherbide, Solomon, Sheridan, Mathew, Sheridan, Jane, Sheridon, Matthew, Shields, Tracy, Sim, Hau V, Sim, Shirlene, Sims, Matt, Singaraveloo, Lydia, Singh, Gurcharan, Singh, Jasmine, Sladesal, Shree, Sloan, Andrew, Slobodian, Peter, Smith, Sophie, Smith, Sarit, Smith, Claire, Smith, Alastair, Smith, Neil, Snowden, Katherine, Solis, Joel, Somios, Denise, Soo, Jade, Spanevello, Michelle, Spaulding, Madeleie, Spence, Laura, Spillane, Liz, Spiteri, Alisha, Sprigg, Naomi, Springett, Sally, Stafford, Lynn, Stainthorp, Katherine, Stark, Kate, Steeden, Louise, Stephen, Ella, Stephenson, Aisling, Stewart, Andrew, Stewart, Orla, Stobie, Emma, Stokes, Chelsea, Streater, Jacqui, Suddens, Charlie-Marie, Suntharalingam, Surenthini, Surana, Narinder, Sutherland, Robyn, Sutherland, Antony, Sutton, David, Sweeney, Connor, Sweet, Reilly, Szucs, Aniko P, Taheri, Leila E., Tailor, Hinesh, Tam, Constantine, Tambakis, George, Tamplin, Mary, Tan, Chee, Tan, Sui, Tan, Joanne, Tan, Zhi, Taran, Tatiana, Tarpey, Fiona, Taseka, Angela, Tasker, Suzy, Tatarczuch, Maciej, Tayabali, Sarrah, Taylor, Hannah, Taylor, Robert, Taylor, Melaine, Taylor-Moore, Ella, Teasdale, Lesley, Tebbet, Elizabeth, Tedjasepstra, Aditya, Tedjaseputra, Aditya, Tepkumkun, Oummy, Terpstra, Andrew, Thomas, Wayne, Thomas, Shanice, Thompson, Rachel, Thornton, Thomas, Thorp, Bronwyn, Thrift, Moi Yap, Thwaites, Phillipa, Timbres, Jasmine, Tindall, Lauren, Tiong, Ing Soo, Tippler, Nicole, Todd, Tony, Todd, Shirley, Toghill, Neil, Tomlinson, Eve, Tooth, Jacinta, Topp, M., Trail, Nicola, Tran, Nguyen, Tran, Elizabeth, Tran, Vi, Treder, Bona, Tribbeck, Michelle, Trochowski, Siobhan, Truslove, Maria, Tse, Tsun, Tseu, Bing, Tucker, David, Turner, Kelly, Turner, Dianne, Turner, Herleen, Turner, Gillian, Twohig, Julie, Tylee, Thomas, Uhe, Micheleine, Underhill, Lauren, V, Joanne, Van der Vliet, Georgina, Van Tonder, Tina, VanderWeyden, Carrie, Varghese, Jerry, Vaughan, Lachlan, Veale, David, Vickaryyous, Nicky, Vince, Kathryn, Von Welligh, Jacoba, Vora, Sona, Wadehra, Karan, Walker, Rebecca, Walker, Stephen, Wallace, Roslyn, Wallniosve, Stephanie, Wallwork, S., Walmsley, Zoe, Walters, Fiona, Wang, Joyce, Wang, Angela, Wang, Chen, Wanyika, Mercy, Warcel, Dana, Wardrobe, Katrina, Warnes, Kristian, Waterhouse, Christopher, Waterworth, Adam, Watson, Caroline, Watson, Edmund, Watts, Emily, Weaver, Emma, Weber, Nicholas, Webley, Kaytie, Welford, Anna, Wells, Matt, Westbury, Sarah, Westcott, Jackie, Western, Robyn, Weston, Julia, White, Jessica, White, Phillipa, Whitehead, Anna, Whitehouse, James, Wieringa, Samantha, Willan, John, Williams, Sandra, Williams, Bethany, Williamson, Stephanie, Willoughby, Brett, Wilmot, Gail, Wilmott, Rosalind, Wilson, Joanna, Wilson, Emma, Wilson, Suzy, Wilson, Heather, Wilson, Caroline, Wilson, Tanya, Wilton, Margaret, Wiltshire, Paula, Wincup, Joanne, Wolf, Julia, Wong, Henna, Wong, Cyndi, Wong, Daniel, Wong, Jonathan, Wong, Shi Qin, Wood, Sarah, Wood, Henry, Wooding, Jackie, Woolley, Kelly, Wright, Myles, Wynn-Williams, Roland, Yannakou, Costas, Yeoh, Zhi Han, Yeung, David, Young, Agnes, Yuen, Flora, Yuen, Agnes, Zaja, Oliver, Zhang, Xiao-Yin, and Zhang, Mei

Published
2025
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17. Fighting barbarians

Author

Tucker, David

Subjects
CASUALTIES, UNCONVENTIONAL WARFARE
Abstract

bibliog

Published
1998

24. Ibrutinib as first-line therapy for mantle cell lymphoma: a multicenter, real-world UK study

Author

Tivey, Ann, Shotton, Rohan, Eyre, Toby A., Lewis, David, Stanton, Louise, Allchin, Rebecca, Walter, Harriet, Miall, Fiona, Zhao, Rui, Santarsieri, Anna, McCulloch, Rory, Bishton, Mark, Beech, Amy, Willimott, Victoria, Fowler, Nicole, Bedford, Claudia, Goddard, Jack, Protheroe, Sam, Everden, Angharad, Tucker, David, Wright, Josh, Dukka, Vasavi, Reeve, Miriam, Paneesha, Shankara, Prahladan, Mahesh, Hodson, Andrew, Qureshi, Iman, Koppana, Manasvi, Owen, Mary, Ediriwickrema, Kushani, Marr, Helen, Wilson, Jamie, Lambert, Jonathan, Wrench, David, Burney, Claire, Knott, Chloe, Talbot, Georgina, Gibb, Adam, Lord, Angela, Jackson, Barry, Stern, Simon, Sutton, Taylor, Webb, Amy, Wilson, Marketa, Thomas, Nicky, Norman, Jane, Davies, Elizabeth, Lowry, Lisa, Maddox, Jamie, Phillips, Neil, Crosbie, Nicola, Flont, Marcin, Nga, Emma, Virchis, Andres, Camacho, Raisa Guerrero, Swe, Wunna, Pillai, Arvind, Rees, Clare, Bailey, James, Jones, Steve, Smith, Susan, Sharpley, Faye, Hildyard, Catherine, Mohamedbhai, Sajir, Nicholson, Toby, Moule, Simon, Chaturvedi, Anshuman, and Linton, Kim

Published
2024
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27. The US is preparing to accuse Russia of disinformation campaigns targeting the presidential election

Author

TUCKER, DAVID KLEPPER ERIC and LEE, MATTHEW

Subjects
The Associated Press -- Target marketing, Target marketing, News agencies -- Target marketing, Disinformation, Presidents -- Elections, News, opinion and commentary
Abstract

WASHINGTON (AP) — The Biden administration is preparing to accuse Russia on Wednesday of https://apnews.com/article/disinformation-election-interference-russia-china-2925ca62c1ba8c1893454ccb2f76785a targeting the U.S. presidential election, according to three people familiar with the matter. Intelligence agencies [...]

Published
2024

28. Ibrutinib improves survival compared with chemotherapy in mantle cell lymphoma with central nervous system relapse

Author

Rusconi, Chiara, Cheah, Chan Y., Eyre, Toby A., Tucker, David, Klener, Pavel, Giné, Eva, Crucitti, Lara, Muzi, Cristina, Iadecola, Sara, Infante, Gabriele, Bernard, Sophie, Auer, Rebecca L., Pagani, Chiara, Duglosz-Danecka, Monika, Mocikova, Heidi, van Meerten, Tom, Cencini, Emanuele, Marin-Niebla, Ana, Williams, Michael E., Angelillo, Piera, Nicoli, Paolo, Arcari, Annalisa, Morello, Lucia, Mannina, Donato, Vitagliano, Orsola, Sartori, Roberto, Chiappella, Annalisa, Sciarra, Roberta, Stefani, Piero M., Dreyling, Martin, Seymour, John F., and Visco, Carlo

Published
2022
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29. Diagnostic uncertainty presented barriers to the timely management of acute thrombotic thrombocytopenic purpura in the United Kingdom between 2014 and 2019

Author

Bull, Tom P., McCulloch, Rory, Nicolson, Phillip L.R., Doyle, Andrew J., Shaw, Rebecca J., Langridge, Alexander, Sayar, Zara, Tucker, David L., Pettit, Michala, Perry, Rita, Thomas, William, Page, Catherine, Whalley, Ioana, Dutt, Tina, Garth, Louise, Lester, Will, Buka, Richard J., Subhan, Mary, Ware, Victoria, Rayment, Rachel, Castle, Daniel, Etherington, Astrid, Carter‐Brzezinski, Luke, Peters, Jayne, Corrigan, Claire, Sharma, Narind, Benson, Gary, Challenor, Sarah, Skinner, Thomas S., Zhao, Rui, McLeod‐Kennedy, Lyndsay A.G., Douglas, Kenneth, Knott, Amy, Smith, Sophie, Wolf, Julia, Todd, Sophie A., McDonald, Vickie, Rampotas, Alexandros, Dean, Christopher, Sangha, Gavinda, Pavord, Sue, Denny, Nicholas, Jaafar, Sarah, McLaughlin, David P.T., Ross, Jennifer E., Karanth, Mamatha, Beverstock, Sarah L., Mansonso, Lynn, Burrows, Samuel H., Tauro, Sudhir, Shenouda, Amir, Bailiff, Benjamin M., Kajita, Daniel, Hermans, Joannes, Goradia, Harshita, Finan, Emily M., Alford, Sarah, Pickard, Keir, Greystoke, Brigit, Fail, Thomas, Abdussalam, Asmaa, Roberts, Lara N, Clark, James B., Heeney, Natalie, Young, Jennifer, Maddox, Jamie, Srinath, Swathy, Khawaja, Jahanzeb, Parkes, Jayne, Babiker, Samah, Hunt, Beverley J., Wheeldon, Sarah L., Kerr, Paul, Tahhan, Molham, Vickers, Mark, Pike, Alexandra C., Hill, Quentin, Mustafa, Nadreen, Almaremi, Azza, Hughes, Emily, McGoldrick, Sean J.F., Loizou, Eleana, James, Izabela, Boyce, Sara R., Farmer, Isabel, Thanigaikumar, Murugaiyan, Wickenden, Katherine, Gooding, Richard, Thornton, Kathryn, Kane, Clare, Cole, Adam, Griffin, JessicaC, Docherty, Suzanne, Dixon, Kiri I., Crowe, Josephine, Sheridan, Mathew, De Lord, Corinne, Sud, Amit, Austin, Anna, Coooper, Nichola, Bailey, Chris, Attwell, Luke, Hall, Rachel, Gray, Benjamin, Chauhan, Salena R., Lokare, Anand, Gudger, Amy, Horgan, Claire, Venkatadasari, Indrani, Kaddam, Israa, Mapplebeck, Claire L., Van Veen, Joost, Raj, Maya, De Abrew, Kanchana, Belsham, Edward, Gyansah, Cecilia, Sadullah, Shalal, Salhan, Beena, Murrin, Richard, Williams, Rhys L., Stewart, Andrew, Cornish, Naomi, Otton, Sophie, Khan, Zeeshan, Ackroyd, Sam, Chen, Lucia Y., Lafferty, Nicholas P., Leonforte, Francesca, Pemberton, Nicholas, Rawi, Emanal, Triantafyllopoulou, Diana, Adiyodi, Jagdish, Yong, Jun, Jones, Elizabeth, Davies, David, Peck, Rachel C., Philip, Robson, Seddon, Thomas, Cahalin, Paul, Prodger, Catherine, Dutton, David A., Sternberg, Alexander J., Chengal, Rajani, Polzella, Paolo, and Scully, Marie

Published
2022
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30. Health outcomes and drug utilisation in children with Noonan syndrome: a European cohort study.

Author

Santoro, Michele, Barisic, Ingeborg, Coi, Alessio, Tan, Joachim, Garne, Ester, Loane, Maria, Odak, Ljubica, Abate, Maria Valentina, Ballardini, Elisa, Cavero-Carbonell, Clara, Gatt, Miriam, Gissler, Mika, Klungsøyr, Kari, Lelong, Nathalie, Tucker, David, Wellesley, Diana, and Morris, Joan K.

Subjects
NOONAN syndrome, DEATH rate, SURGERY, HOSPITAL care, HEALTH outcome assessment, DRUG utilization, SCHOOL children, COHORT analysis
Abstract

Background: Noonan Syndrome (NS) is a rare multisystemic disorder with heterogeneous phenotypic manifestations. The aim of this study was to analyse rates of survival, hospitalisation, surgeries and prescriptions in children born with NS in the first 10 years of life. Methods: This is a multi-centre population-based cohort study. Data on 175 liveborn children diagnosed with NS from 11 EUROCAT congenital anomaly registries were linked to healthcare databases. Each registry applied a common data model to standardise data and run common syntax scripts to produce aggregated results which were pooled using random effects meta-analyses. Results: Mortality rates were high in the first year of life with 5.4% (95%CI 1.5%-10.1%) of children dying before the age of 1 year with a further 2% dying up to age 5. In the first year, 87.9% (95%CI 75.3%-94.3%) of children were hospitalized and the median Length Of hospital Stay (LOS) was 15.3 days (95%CI 9.3–21.2). After the first year, the proportion of children hospitalized remained higher than 70%, but the LOS decreased to 1.3 days per year. In the first 5 years, 65.2% of children underwent a median of two surgical procedures. The median age at first surgery was 29 weeks. The proportion of children with an antibiotic prescription increased from 53.6% at age 1 to 62.4% yearly until 4 years of age. Conclusions: Children with NS have high mortality and morbidity not only in the first year of life but also up to five years of age. This study evaluated the health burden of NS and provided information for clinicians, health-care providers and families. [ABSTRACT FROM AUTHOR]

Published
2025
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31. Blockchain Research and Development Activities Sponsored by the U.S. Department of Energy and Utility Sector.

Author

Credle, Sydni, Harun, Nor Farida, Johnson, Grant, Lawrence, Jeremy, Lawson, Christina, Hollern, Jason, Malik, Mayank, Gourisetti, Sri Nikhil Gupta, Sebastian-Cardenas, D. Jonathan, Johnson, Beverly E., Markel, Tony, and Tucker, David

Subjects
SUPPLY chain management, EVIDENCE gaps, ENERGY security, BLOCKCHAINS, ENERGY industries
Abstract

This article provides an in-depth analysis of blockchain research in the energy sector, focusing on projects funded by the U.S. Department of Energy (DOE) and comparing them with industry-funded initiatives. A total of 110 funded activities within the U.S. power industry were successfully tracked and mapped into a newly developed categorization framework. This framework is designed to help research agencies to systematically understand their funded portfolio. Such characterization is expected to help them make effective investments, identify research gaps, measure impact, and advance technological progress to meet national goals. In line with this need, the proposed framework proposes a 2-D categorization matrix to systematically classify blockchain efforts within the energy sector.Under the proposed framework, the Energy System Domain serves as the primary classification dimension, categorizing use cases into 30 distinct applications. The second dimension, Blockchain Properties, captures the specific needs and functionalities provided by Blockchain technology. The aim was to capture blockchain's applicability and functionality: where and why blockchain? Principles behind the selection of the viewpoint dimensions were carefully defined based on consensus obtained through the Blockchain for Optimized Security and Energy Management (BLOSEM) project. The mapped results show that activities within the Grid Automation, Coordination, and Control (31.8%), Marketplaces and Trading (25.5%), Foundational Blockchain Research (19.1%), and Supply Chain Management (17.3%) domains have been actively pursued to date. The three leading specific use case applications were identified as Transactive Energy Management for Marketplaces and Trading, Asset Management for Supply Chain Management, and Fundamental Blockchain for Foundational Blockchain Research. The Marketplaces and Trading and Retail Services Enablement domains stood out as being favored by industry by a factor greater than 2 (2.3 and 2.6, respectively), yet there seemed to be little to zero investment from DOE. Approximately 76% of the total projects prioritized Immutability, Identity Management, and Decentralization and/or Disintermediation compared to Asset Digitization and/or Tokenization, Automation, and Privacy and/or Anonymity. The greatest discrepancies between DOE and industry were in Asset Digitization and/or Tokenization and Automation. The industry efforts (36% in Asset Digitization/Tokenization and 22% in Automation) was 14 times and 2.4 times, respectively, more intensive than the DOE-sponsored efforts, indicating a significant discrepancy in industry versus government priorities. Overall, quantifying DOE-sponsored projects and industry activities through mapping provides clarity on portfolio investments and opportunities for future research. [ABSTRACT FROM AUTHOR]

Published
2025
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33. Safety, immunogenicity, and efficacy of a COVID-19 vaccine (NVX-CoV2373) co-administered with seasonal influenza vaccines: an exploratory substudy of a randomised, observer-blinded, placebo-controlled, phase 3 trial

Author

Soiza, Roy L., Brittain-Long, Robin, Scicluna, Chiara, Edwards, Carole, Mackay, Lynn, D'Allesandro, Mariella, Nicol, Amy, Norris, Karen, Mann, Sandra, Lawrence, Heather, Valentine, Ruth, Viljoen, Marianne Elizabeth, Pretswell, Carol H., Nicholls, Helen, Munsoor, Imrozia, Meyrick, Agnieszka, Kyriakidou, Christina, Iyengar, Shalini, Jamal, Arham, Richards, Nick, Price, Helen, Rowbotham, Bridie, Bird, Danielle, Smith, Karen, Littler, Olga, Fielding, Kirsty, Townsend-Rose, Anna, Miller, Karen, Davis, Jessica, Elliot-Garwood, Alison, Trottier, Lauren, Edwards, Paul, McFarland, Margaret, Osanlou, Orod, Longshaw, Laura, Stockport, Jane, Grundy, Lynne, Broad, Katharine Lucy, Regan, Karen, Storton, Kim, Ryan-Wakeling, Declan, Wilson, Brad, Munisamy, Malathy, Wright, John, Shenoy, Anil, English, Beverley, Brear, Lucy, Cicconi, Paola, Boffito, Marta, Milinkovic, Ana, Byrne, Ruth, Movahedi, Roya, Housman, Rosalie, Kara, Naveed, Brown, Ellen, Cipriani, Andrea, Attenburrow, Mary-Jane, Smith, Katharine A., Packham, Jonathan, Sparrow, Geoff, Smith, Richard, Rosier, Josephine M., Saja, Khalid, Nago, Nyasha, Camilleri, Brian, Immanuel, Anita, Hamblin, Mike, Osagie, Rawlings, Mohan, Mahalakshmi, Floyd, Hilary, Goddard, Suzanne, Mutgi, Sanjay, Evans, John, McKeon, Sean, Vilimiene, Neringa, Chicano, Rosavic, Hayre, Rachel, Pandaan, Alice, Henshall, Catherine, Serrano, Sonia, Mazzella, Andrea, Rajeswaran, Thurkka, Mathew, Moncy, Bisnauthsing, Karen, Bremner, Laura, Fok, Henry, Morselli, Franca, Cinardo, Paola, Merrick, Blair, Sowole, Lucy, Broadhead, Samantha, Palmer, Natalie, Cordle, Jessica, Goldsmith, Jaimie Wilson, Cooney, Enya, Jackson, Beth, Jayatilleke, Thilina, Cheng, Zelda, Helliwell, Toby, Chudyk, Adrian, Giemza, Rafaela, Villajin, John Lord, Yogo, Noah, Makanju, Esther, Dulawan, Pearl, Nagra, Deepak, Buazon, April, Russell, Alice, Bird, Georgie, Heer, Amardeep, Sarmiento, Rex, Sanghera, Balraj, Mullin, Melanie, Champion, Adam, Bevan, Aisling, Iqbal, Kinzah, Johnson, Alshia, Clark, Rebecca, Shaw, Sarah, Shaw, Steven, Chalk, Amanda, Lovatt, Martin, Lillicrap, Caroline, Parker, Angela, Hansel, Jan, Wong, Zhi, Gan, Galvin, Tuma, Eyad, Minton, Jane, Murira, Jennifer, Saman, Razan, Hall, Alistair, Holliday, Kyra, Khan, Zara, Calderwood, James, Twigg, George, Baker, Helena, Corrigan, Julie, Houseman, Katy, Raguvanshi, Subhra, Heining, Dominic, Weddell, Jake, Glaves, Liz, Thompson, Kim, Davies, Francis, Lambley Burke, Ruth, Thomson, Emma C., Saralaya, Dinesh, Berry, Lisa, Hopewell, Nancy, Gerdes, Leigh, Pacurar, Mihaela, Faust, Saul N., Turner, Jeremy, Jeanes, Christopher, Cooper, Adele, Keshet-Price, Jocelyn, Coke, Lou, Cambell-Kelly, Melissa, Dhatariya, Ketan, Williams, Claire, Marks, Georgina, Sudbury, James, Rodolico, Lisa, Bradley, Judy, Carr, Sharon, Martin, Roisin, Madden, Angelina, Biagioni, Paul, McKenna, Sonia, Clinton, Alison, O'Kane, Maurice, Carter, Justin, Dewhurst, Matthew, Wetherill, Bill, Hoggarth, Thandiwe, Collins, Katrina Lennon, Chowdhury, Marie, Nathoo, Adil, Heinen, Anna, MacDonald, Orla, Hurducas, Claudia, Cifuentes, Liliana, Gill, Harjeevan, Gibson, Andy, West, Raha, Ewing, Jane, Blacow, Rachel, Haughney, John, MacDonald, Jonathan, Seenan, John Paul, Webb, Stewart, O'Leary, Colin, Muir, Scott, White, Beth, Ritchie, Neil, McAuley, Daniel F., Stewart, Jonathan, D'Alessandro, Mariella, Lakeman, Nicki, Purandare, Laura, Browne, Duncan, Tucker, David, Luck, Peter, Everden, Angharad, Trembath, Lisa, Visick, Michael, Morley, Nick, Reid, Laura, Chenoweth, Helen, Maclean, Kirsty, Sheridan, Ray P., Burden, Tom, Lunt, Craig Francis, Todd, Shirley, Estcourt, Stephanie, Pearce, Jasmine Marie, Wilkins, Suzanne, Love-Rouse, Cathryn, Torok-Pollok, Eva, Youle, Mike, Madge, Sara, Solomon, Danielle, Nandani, Aarti, North, Janet M., Hemat, Nargis, Newport, Rachel, Kalra, Philip A., Chukwu, Chukwuma, Wickens, Olivia, O'Loughlin, Vikki, Mistry, Hema, Harrison, Louise, Oliver, Robert, Peers, Anne-Marie, Zadik, Jess, Doyle, Katie, Chadwick, David R., Colling, Kerry, Wroe, Caroline, Branch, Marie, Chilvers, Alison, Essex, Sarah, Stone, Mark, San Francisco Ramos, Alberto, Beales, Emily, Bird, Olivia, Danos, Zsofia, Fofie, Hazel, Hultin, Cecilia, Ikram, Sabina, Mabesa, Fran, Mescall, Aoife, Pereira, Josyanne, Pearce, Jennifer, Sutton, Natalina, Snashall, Emma, Baxter, David Neil, Bennett, Sara, Suggitt, Debbie, Hughes, Kerry, Woodyatt, Wiesia, Beacon, Lynsey, Kent, Alissa, Cooper, Chris, Rudic, Milan, Tunstall, Simon, Jackson, Matthew, Hombersley, Claire, Moore, Patrick, Cutts, Rebecca, Higham, Andrew, Bukhari, Marwan, Elnaggar, Mohamed, Glover, Michelle, Richardson, Fiona, Dent, Alexandra, Mirza, Shahzeb, Ark, Rajiv, Han, Jennie, Hope, Suzy V., Mitchelmore, Philip J., Osanlou, Rostam, Freedman, Andrew, Cooper, Alison, Burton, Katherine, Katechia, Kashyap, Barrett, Michael, Salkeld, Jo, Hill, Natalie, Lee, Nathaniel, Perkins, Jon, Fox, Polly, Toback, Seth, Galiza, Eva, Cosgrove, Catherine, Galloway, James, Goodman, Anna L, Swift, Pauline A, Rajaram, Sankarasubramanian, Graves-Jones, Alison, Edelman, Jonathan, Burns, Fiona, Minassian, Angela M, Cho, Iksung, Kumar, Lakshmi, Plested, Joyce S, Rivers, E Joy, Robertson, Andreana, Dubovsky, Filip, Glenn, Greg, and Heath, Paul T

Published
2022
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35. From stable carbenes to stable Blatter-type radicals

Author

Tucker, David Edward

Subjects
540
Abstract

The overall theme of this project was investigation of the proton-transfer of stable carbene species. Stable carbenes, such as N-heterocyclic carbenes (NHCs) have recently been the focus of a great deal of research, due to their useful nature as organocatalysts for a wide range of synthetic transformations. As NHCs are typically generated in situ by deprotonation of their conjugate acids, the kinetics of protontransfer of NHCs and related species are highly important areas of research. Using a kinetic method, the C(3)H acidity of a series of NHC conjugate acids, (imidazolium and triazolium based) was investigated at I = 1.0, 25 °C. The acidity was probed by H/D exchange experiments monitored by 1H NMR spectroscopy in D2O solutions at varied pD, from which the pseudo first-order rate constants of exchange kex (s−1) could be determined. Comparing the kex values at various pDs allows determination of the second-order rate constant of exchange kDO (M−1 s−1), for each azolium ion, and using a secondary solvent isotope effect (kDO/kHO = 2.4), estimates of pKa could be made by kinetic acidity, as the reprotonation of carbenes in water is known to be limited by solvent reorganisation (kHOH = kreorg = 1011 s−1). pD rate profiles of ortho-halogen substituted triazolium salts studied by this method showed an altered dependence on pD at low pD, an effect which has previously been observed in an N-C6F5 triazolium salt. This effect is believed to originate from N1 protonation of the triazolium ring system under acidic conditions, to generate a dicationic triazolium species. Ortho-halogen substitution is believed to promote this effect by raising the pKa of the N1 position. Two imidazolium salts with fused furan rings and exocyclic nitrogen atoms were also studied by this method and did not show altered dependence on pD. The carbon acidity C(3)H positions of these salts was significantly higher than is generally predicted for N-aryl imidazolium salts. The origin of this increased acidity is assigned to increased σ-electron withdrawal and π-donation by the O atom of the fused furan ring. Bis(amino)cyclopropenylidenes (BACs) are a relatively new field of stable carbenes, and the only family with no α-heteroatoms to the carbene centre. Several BAC conjugate acids were prepared using existing literature procedures, however, attempts to prepare of N-aryl BACs by the use of N-methylaniline produced only trisubstituted cyclopropenium species. Hydrolysis of this to cyclopropenone, followed by iii chlorination and reaction with triphenylphosphine produced a phosphonium salt, instead of the desired BAC conjugate acid. Using diethylamine produced a mixture of disubstituted and trisubstituted cyclopropenium salts. The disubstituted product could not be purified after the use of triphenylphosphine. Replacement with triethyl phosphite afforded a stable phosphonato cyclopropenium salt. Base hydrolysis of the phosphonate yielded N-ethyl BAC conjugate acid, with competing elimination of ethanol. The carbon acidity of the C(3)H position of two bis(amino)cyclopropenium salts was studied by the same kinetic acidity method used to investigate NHC conjugate acids. Control experiments determined a lack of buffer catalysis and confirmed H/D exchange had occurred. The lack of buffer catalysis suggests that as with NHCs, reprotonation of BACs is limited by solvent reorganisation (kHOH = kreorg = 1011 s−1). The determined values of kDO could be converted to kHO (kDO/kHO = 2.4), which in turn was used to estimate pKa (~22). This value is between the approximate acidity of N-aryl and N-alkyl imidazolium salts. Despite the lack of α-heteroatoms, the BAC is believed to be stabilised by a highly acute bond angle at the carbene centre and by σ-withdrawal and π-donation from the exocyclic nitrogen substituents. The unusual hydrolytic behaviour of the phosphonato-cyclopropenium species was investigated. Further phosphonato-cyclopropenium salts were prepared by reaction of alkyl phosphites with chloro-cyclopropenium salts. Hydrolysis of these phosphonates largely favoured elimination of a BAC compared to ethoxide, contrary to what would be expected from the respective pKa values of the leaving groups. The kinetics of hydrolysis was investigated using 31P NMR spectroscopy at 25°C, I = 1.0 M in various K2CO3 buffers in H2O and D2O. A first-order dependence on hydroxide/deuteroxide was observed with no significant solvent kinetic isotope effect. Variable temperature experiments suggested an associative mechanism, and at varied temperature, ionic strength and basicity, identical ratios of products were produced. From this information, it is proposed that hydrolysis proceeds via either an AN+DN or SN2@P mechanism. The unusual ratio of products could be potentially be explained by rate-limiting pseudorotation during an AN+DN mechanism. Investigation of the organocatalytic chemistry of BACs involved following the BACcatalysed intramolecular Stetter reaction by 1H NMR spectroscopy at 25 °C. The degree of steric hindrance around the BAC was of vital importance, as the reaction did not iv proceed using bulky catalysts. A similar 2-substituent effect of aryl aldehydes in reaction with NHCs was observed with BACs. Several hydroxy-aryl adducts of BACs were prepared and isolated, and the formation of a d1-acyl anion equivalent was investigated by H/D exchange experiments. Exchange was observed under organocatalytic conditions, and experiments monitored by 1H NMR in highly basic aqueous (D2O, I = 1.0, 25 °C) conditions found exchange to occur. The second-order rate constants of exchange kDO showed a moderate aryl substituent effect between adducts. Finally, the serendipitous discovery of a “Blatter”-type radical formed from carbenoid species Nitron found by previous MChem student Jacob A. Grant was investigated. A further radical derivative compound was discovered and both were fully characterised. Further synthetic and spectroscopic experiments suggested a possible mechanism for the formation of these radicals. Both radicals’ properties were found to be largely similar to previous examples of “Blatter”-type radicals through cyclic voltammetry and EPR experiments.

Published
2018

36. Safety and immunogenicity of concomitant administration of COVID-19 vaccines (ChAdOx1 or BNT162b2) with seasonal influenza vaccines in adults in the UK (ComFluCOV): a multicentre, randomised, controlled, phase 4 trial

Author

Adams, Kirsty, Alaee, Seema, Aley, Parvinder K., Allum, Emma, Anthony, Sally, Ashton, Kate, Awal, Tanya, Barnett, Liz, Barratt, Alison, Barron, Charlotte, Baum, Holly, Beard, Chloe, Bennett, Lorna, Bird, Samuel, Bishop, Sarah, Bisset, Jess, Bodalia, Pritesh, Bowles, Jane, Bowyer, Catherine, Bradburn, Kirstie, Bray, Jonathan J.H., Bressington, Catherine, Brimfield, Matthew, Broad, Lauren, Brown, Pauline, Brydon-Hill, Ruth, Burge, Sharon, Carmichael, David, Chohan, Gurjit, Clark, Tonia, Close, Adrianne, Coleman, Tom, Cowley, Claire, Cranfield, Charlotte, Cross, Eleanor, D'Agostino, Alyssa, D'Arcangelo, Silvia, David Otter, Ashley, Davies, Kate, Davies, Catrin, Davies, Ru, Davies, Louisa, Driver, Kimberley, Eglinton, Charlotte, Ekblad, Charlotte, Eldridge, Emma, Evans, Teriann, Evans, Mim, Evans, Isabel, F Mujadidi, Yama, Farrow, Amanda, Faulkner, Beverley, Feltham, Sally, Figueirido, Susan, Ford, Jamie, Foxwell, David, Frayling, Sharon, Gardiner, Sophie, Gooch, Karen E., Goodwin, Jayne, Halliday, Alice, Hamal, Shama, Harrhy, Sarah, Harris, Andrew, Haxton, Lesley, Haynes, Matthew, Hazell, Mae, Hembrough, Tracey, Hewson, Jacqueline, Hicks, Bethany, Higgins, Thomas, Hill, Michelle, Hills, Alex, Hilton, Zoe, Hitchings, Benjamin, Hua, Cheryl, Iftikhar, Hina, Iqbal, Attya, Jones, Laura, Jones, Nicola, Kellett Wright, Johanna, Kidd, Sarah, Kirby, Alison, Knibbs, Lucy, Lamb, Jenny, Langton, Helen, Leach, Rwth, Lewis-Clarke, Phoebe, Lloyd, Amy, Maclean, Kirsty, Manning, Nicola, Marriott, Anthony, McFadzean, Isobel Joy, McLaughlin, Maeve, McQueen, Alison, Mills, Bianca, Naik, Gurudutt, Nicholls, Lisa, Norman, Chris, Northcott, Keren, Nyland, Kerry, Oliver, Catherine, Oliver, Elizabeth, Oliver, Jennifer, Owen, Diana, Paterson, Jemma, Pearce, Lauren, Pegler, Suzannah, Price, Zoe, Pynsent, William B., Ramos, Lidia, Rampling, Tommy, Rea, David, Regan, Karen, Riaz, Tawassal, Ricamara, Marivic, Rice, Danielle, Rich, Melody, Roots, Marianne, Ryan, Kathryn Ann, Sakagami, Yukari, Salem, Ahmed, Salter-Hewitt, Jade, Samuels, Michelle, Santoloce, Silvia, Seaman, Siwan, Seneviratne, Michael, Shankland, Sara, Silva, Louise, Smart, Katie, Smith, Rachel M., Smith, Joyce, Stringer, Rebecca, Talbot, Helen, Tarling, Teresa, Taylor, Sarah Louise, Thomas, Amy, Tilzey, Grace, Townley, Gina, Trembath, Lisa, Turkentine, Kate, Turner, Kelly, Tyler, Jenny, Ugoji, Jacinta, Wale, Katharine, Walker-Smith, Terrie, Walton, Maggie, Warnes, Barbara, Whittley, Sarah, Williams, Jennie, Williams, Gail, Williamson, Kevin, Yim, Yee Ting Nicole, Youlden, Nicola, Lazarus, Rajeka, Baos, Sarah, Cappel-Porter, Heike, Carson-Stevens, Andrew, Clout, Madeleine, Culliford, Lucy, Emmett, Stevan R, Garstang, Jonathan, Gbadamoshi, Lukuman, Hallis, Bassam, Harris, Rosie A, Hutton, David, Jacobsen, Nick, Joyce, Katherine, Kaminski, Rachel, Libri, Vincenzo, Middleditch, Alex, McCullagh, Liz, Moran, Ed, Phillipson, Adrian, Price, Elizabeth, Ryan, John, Thirard, Russell, Todd, Rachel, Snape, Matthew D, Tucker, David, Williams, Rachel Lauren, Nguyen-Van-Tam, Jonathan S, Finn, Adam, and Rogers, Chris A

Published
2021
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38. Macrolide and lincosamide antibiotic exposure in the first trimester of pregnancy and risk of congenital anomaly: A European case-control study

Author

Leke, Aminkeng Zawuo, Dolk, Helen, Loane, Maria, Casson, Karen, Nelen, Vera, Barišić, Ingeborg, Garne, Ester, Rissman, Anke, O’Mahony, Mary, Neville, Amanda J., Pierini, Anna, Bergman, Jorieke E.H., Klungsøyr, Kari, Materna-Kiryluk, Anna, Bielenska, Anna Latos, Carbonell, Clara Cavero, Addor, Marie-Claude, and Tucker, David

Published
2021
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39. Assessing the cellular and adhesive interactions in in vitro models of mantle cell lymphoma

Author

Tucker, David

Subjects
616.99, mantle cell lymphoma, microenvironment, lymphoma, adhesion
Abstract

Mantle cell lymphoma (MCL) is a rare lymphoproliferative disorder (LPD) that has very poor survival. Like other LPDs, the neoplastic cells of MCL have an intimate dependence upon accessory cells within haematopoietic tissues. Understanding and exploiting the tissue-relationships of the mantle cells may therefore lead to further new approaches to treatment. This study work has set out to construct an in vitro system to model relevant aspects of the tissue-dependent behaviour of the neoplastic mantle cells, seeking to establish the link between in vitro behaviour and clinical phenotype, and establishing the feasibility of this system to study the effects of different therapeutic interventions. The first experimental chapter employs relevant mouse and human stromal models to mirror the tissue environment of MCL in vivo. Testing relevant agents, the work establishes that the system can identify different behaviour between indolent and aggressive forms of MCL, and demonstrates a particular importance for CD40 ligand both in the proliferation and survival of the neoplastic mantle cells, but shows also how these effects are modulated by the soluble factors interleukin-4 (IL-4) and the toll-like receptor-9 ligand (TLR9-L). The second experimental chapter examines the adhesion molecules expressed on MCL cells. Considerable variation in the level of expression is observed between cases, but overall the cases express particularly high levels of the integrin receptors LFA-1 (detected by alpha chain CD11a) and VLA-4 (detected by alpha chain CD49d). Cases also showed a significant difference in overall adhesion and chemokine-receptor expression between cases that had either a nodal or leukaemic clinical pattern, although no single adhesion molecule was characteristic of clinical phenotype. The final experimental chapter looked at 3-D culture of MCL. Within tissues MCL grows in a 3-D rather than 2-D matrix and it is recognised that cells employ different forms of adhesion and migration within the different spatial environments. This chapter establishes the feasibility of growing cells in 3-D systems and looks at optimal conditions to preserve and examine the cellular characteristics of cells within a 3-D environment. Overall, this thesis demonstrates the feasibility and pathobiological relevance of ex vivo culture of MCL cells giving insights into the factors that drive MCL survival and proliferation and the correlation between in vitro behaviour and clinical phenotype. It is proposed that this work can be expanded to examine therapeutic interventions in the disorder.

Published
2017

40. Signal Detection in EUROmediCAT: Identification and Evaluation of Medication–Congenital Anomaly Associations and Use of VigiBase as a Complementary Source of Reference

Author

Cavadino, Alana, Sandberg, Lovisa, Öhman, Inger, Bergvall, Tomas, Star, Kristina, Dolk, Helen, Loane, Maria, Addor, Marie-Claude, Barisic, Ingeborg, Cavero-Carbonell, Clara, Garne, Ester, Gatt, Miriam, Khoshnood, Babak, Klungsøyr, Kari, Latos-Bielenska, Anna, Lelong, Nathalie, Lutke, Reneé, Materna-Kiryluk, Anna, Nelen, Vera, Nevill, Amanda, O’Mahony, Mary, Mokoroa, Olatz, Pierini, Anna, Randrianaivo, Hanitra, Rissmann, Anke, Tucker, David, Wiesel, Awi, Yevtushok, Lyubov, and Morris, Joan K

Published
2021
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45. Administrative Procedure for the Generalist.

Author

Tucker, David G.

Subjects
Administrative procedure -- Laws, regulations and rules, Evidence (Law) -- Laws, regulations and rules, Discovery (Law) -- Laws, regulations and rules, Government regulation, Florida. Statutes (Fla. Stat. 120), Administrative Procedure Act
Abstract

For many attorneys, the prospect of a case governed by the Administrative Procedure Act (1) (APA) is a source of fear: fear of a thicket of laws and rules with [...]

Published
2021

47. Hospital care in the first 10 years of life of children with congenital anomalies in six European countries:data from the EUROlinkCAT cohort linkage study

Author

Morris, Joan K, Loane, Maria, Wahlich, Charlotte, Tan, Joachim, Baldacci, Silvia, Ballardini, Elisa, Cavero-Carbonell, Clara, Damkjær, Mads, García-Villodre, Laura, Gissler, Mika, Given, Joanne, Gorini, Francesca, Heino, Anna, Limb, Elizabeth, Lutke, Renee, Neville, Amanda, Rissmann, Anke, Scanlon, Leuan, Tucker, David F, Urhoj, Stine Kjaer, de Walle, Hermien Ek, Garne, Ester, Morris, Joan K, Loane, Maria, Wahlich, Charlotte, Tan, Joachim, Baldacci, Silvia, Ballardini, Elisa, Cavero-Carbonell, Clara, Damkjær, Mads, García-Villodre, Laura, Gissler, Mika, Given, Joanne, Gorini, Francesca, Heino, Anna, Limb, Elizabeth, Lutke, Renee, Neville, Amanda, Rissmann, Anke, Scanlon, Leuan, Tucker, David F, Urhoj, Stine Kjaer, de Walle, Hermien Ek, and Garne, Ester

Abstract

OBJECTIVE: To quantify the hospital care for children born with a major congenital anomaly up to 10 years of age compared with children without a congenital anomaly.DESIGN, SETTING AND PATIENTS: 79 591 children with congenital anomalies and 2 021 772 children without congenital anomalies born 1995-2014 in six European countries in seven regions covered by congenital anomaly registries were linked to inpatient electronic health records up to their 10th birthday.MAIN OUTCOME MEASURES: Number of days in hospital and number of surgeries.RESULTS: During the first year of life among the seven regions, a median of 2.4% (IQR: 2.3, 3.2) of children with a congenital anomaly accounted for 18% (14, 24) of days in hospital and 63% (62, 76) of surgeries. Over the first 10 years of life, the percentages were 17% (15, 20) of days in hospital and 20% (19, 22) of surgeries. Children with congenital anomalies spent 8.8 (7.5, 9.9) times longer in hospital during their first year of life than children without anomalies (18 days compared with 2 days) and 5 (4.1-6.1) times longer aged, 5-9 (0.5 vs 0.1 days). In the first year of life, children with gastrointestinal anomalies spent 40 times longer and those with severe heart anomalies 20 times longer in hospital reducing to over 5 times longer when aged 5-9.CONCLUSIONS: Children with a congenital anomaly consume a significant proportion of hospital care resources. Priority should be given to public health primary prevention measures to reduce the risk of congenital anomalies.

Published
2024

48. Higher risk of cerebral palsy, seizures/epilepsy, visual- and hearing impairments, cancer, injury and child abuse in children with congenital anomalies:Data from the EUROlinkCAT study

Author

Urhoj, Stine Kjaer, Morris, Joan, Loane, Maria, Ballardini, Elisa, Barrachina-Bonet, Laia, Cavero-Carbonell, Clara, Coi, Alessio, Gissler, Mika, Given, Joanne, Heino, Anna, Jordan, Sue, Neville, Amanda, Santoro, Michele, Tan, Joachim, Tucker, David, Wellesley, Diana, Garne, Ester, Damkjaer, Mads, Urhoj, Stine Kjaer, Morris, Joan, Loane, Maria, Ballardini, Elisa, Barrachina-Bonet, Laia, Cavero-Carbonell, Clara, Coi, Alessio, Gissler, Mika, Given, Joanne, Heino, Anna, Jordan, Sue, Neville, Amanda, Santoro, Michele, Tan, Joachim, Tucker, David, Wellesley, Diana, Garne, Ester, and Damkjaer, Mads

Abstract

AIM: The aim is to examine the risk of cerebral palsy, seizures/epilepsy, visual- and hearing impairments, cancer, injury/poisoning and child abuse in children with and without a congenital anomaly up to age 5 and 10 years.METHODS: This is a population-based data linkage cohort study linking information from the European Surveillance of Congenital Anomalies network (EUROCAT) and birth registries to hospital discharge databases. We included 91 504 live born children with major congenital anomalies born from 1995 to 2014 from nine EUROCAT registries in five countries and 1 960 727 live born children without congenital anomalies (reference children). Prevalence and relative risk (RR) were estimated for each of the co-morbidities using Kaplan-Meier survival estimates.RESULTS: Children with congenital anomalies had higher risks of the co-morbidities than reference children. The prevalences in the reference children were generally very low. The RR was 13.8 (95% CI 12.5-15.1) for cerebral palsy, 2.5 (95% CI 2.4-2.6) for seizures/epilepsy, 40.8 (95% CI 33.2-50.2) for visual impairments, 10.0 (95% CI 9.2-10.9) for hearing loss, 3.6 (95% CI 3.2-4.2) for cancer, 1.5 (95% CI 1.4-1.5) for injuries/poisoning and 2.4 (95% CI 1.7-3.4) for child abuse.CONCLUSION: Children with congenital anomalies were more likely to be diagnosed with the specified co-morbidities compared to reference children.

Published
2024

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