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1. How to: identify non-tuberculous Mycobacterium species using MALDI-TOF mass spectrometry

Author

Alcaide, F., Amlerová, J., Bou, G., Ceyssens, P.J., Coll, P., Corcoran, D., Fangous, M.-S., González-Álvarez, I., Gorton, R., Greub, G., Hery-Arnaud, G., Hrábak, J., Ingebretsen, A., Lucey, B., Marekoviċ, I., Mediavilla-Gradolph, C., Monté, M.R., O'Connor, J., O'Mahony, J., Opota, O., O'Reilly, B., Orth-Höller, D., Oviaño, M., Palacios, J.J., Palop, B., Pranada, A.B., Quiroga, L., Rodríguez-Temporal, D., Ruiz-Serrano, M.J., Tudó, G., Van den Bossche, A., van Ingen, J., and Rodriguez-Sanchez, B.

Published
2018
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5. Major differences in organization and availability of health care and medicines for HIV/TB coinfected patients across Europe

Author

Mansfeld, M, Skrahina, A, Shepherd, L, Schultze, A, Panteleev, A, Miller, R, Miro, J, Zeltina, I, Tetradov, S, Furrer, H, Kirk, O, Grzeszczuk, A, Bolokadze, N, Matteelli, A, Post, F, Lundgren, J, Mocroft, A, Efsen, A, Podlekareva, D, Losso, M, Toibaro, J, Palmero, D, Bartoletti, B, E., W, Gear, O, Messina, O, Michans, M, Laplume, H, David, D, Marson, C, Scapelatto, F, Dalessandro, D, Lupo, S, Costilla Campero, G, Herbst, M, Remondegui, C, Elias, C, Karpov, I, Vassilenko, A, Skrahina, E, Skrahin, A, Zalutskya, A, Kondratenko, O, Mitsura, V, Bondarenko, V, Suetnov, O, Paduto, D, Dewit, S, Payen, M, Noscoi, C, Kabeya, K, M., W, Cortes, C, Obel, N, Kronborg, G, Iljna, V, Kummik, T, Bryand, M, Dabis, F, Lanchava, N, Bablishvili, N, Goginashvili, L, Mikiashvili, L, Mshvidobadze, K, Girardi, E, Di Biagio, A, Apostoli, A, Barzoni, S, Lapadula, G, Purgatorio, M, Carbonara, S, Rozentale, B, Janushkevich, I, Caplinskas, S, Kancauskienne, Z, Caplinskienne, I, Crabtree, B, Pina, A, Madero, J, Mosqueda, J, Villanueva, J, Bura, M, Garlicki, A, Inglot, M, Knysz, B, Kozlowska, J, Loster, J, Mularska, E, Podlasin, R, Thompson, M, Wiercinska-Drapalo, A, Duiculescu, D, Rakhmanova, A, Yakovlev, A, Turkalova, A, Vlasova, Y, Trotimora, T, Borodulina, E, Chumanova, L, Mashkova, Y, Cayla, J, Moreno, A, Millet, J, Orcau, A, Fina, L, del Bano, L, Roldan, L, Romero, A, Martinez, J, Manzardo, C, Gonzalez, J, Tudo, G, Knobel, H, Sanchez, F, Salvado, M, Curran, A, Tortola, M, Pozamczer, D, Saumoy, M, Alcaide, F, Martinez-Lacasa, X, Cuchi, E, Sambeat, M, Pomar, V, Coll, P, Miralles, P, Moreno, S, Iribarren, J, Ibarguren, M, Aldamiz, T, Rickenbach, M, Sagette, M, Chapman, A, Dockrell, D, Wilkins, E, Cooke, G, Ainsworth, J, Macallen, D, Dhar, J, Vora, N, Mullaney, S, Kegg, S, Kyselyova, G, Mansfeld M., Skrahina A., Shepherd L., Schultze A., Panteleev A., Miller R., Miro J., Zeltina I., Tetradov S., Furrer H., Kirk O., Grzeszczuk A., Bolokadze N., Matteelli A., Post F., Lundgren J., Mocroft A., Efsen A., Podlekareva D., Losso M. H., Toibaro J. J., Palmero D., Bartoletti B. J., E. Warley, Gear O., Messina O. G., Michans M., Laplume H., David D., Marson C., Scapelatto F. P., Dalessandro D., Lupo S., Costilla Campero G., Herbst M., Remondegui C., Elias C., Karpov I., Vassilenko A., Skrahina E., Skrahin A., Zalutskya A., Kondratenko O., Mitsura V., Bondarenko V., Suetnov O., Paduto D., Dewit S., Payen M. C., Noscoi C., Kabeya K., M. Wolff, Cortes C., Obel N., Kronborg G., Iljna V., Kummik T., Bryand M., Dabis F., Lanchava N., Bablishvili N., Goginashvili L., Mikiashvili L., Mshvidobadze K., Girardi E., Di Biagio A., Apostoli A., Barzoni S., Lapadula G., Purgatorio M., Carbonara S., Rozentale B., Janushkevich I., Caplinskas S., Kancauskienne Z., Caplinskienne I., Crabtree B., Pina A., Madero J. S., Mosqueda J., Villanueva J. A., Bura M., Garlicki A., Inglot M., Knysz B., Kozlowska J., Loster J., Mularska E., Podlasin R., Thompson M., Wiercinska-Drapalo A., Duiculescu D., Rakhmanova A., Yakovlev A., Turkalova A., Vlasova Y., Trotimora T., Borodulina E., Chumanova L., Mashkova Y., Miro J. M., Cayla J. A., Moreno A., Millet J. P., Orcau A., Fina L., del Bano L., Roldan L. L., Romero A., Martinez J. A., Manzardo C., Gonzalez J., Tudo G., Knobel H., Sanchez F., Salvado M., Curran A., Tortola M. T., Pozamczer D., Saumoy M., Alcaide F., Martinez-Lacasa X., Cuchi E., Sambeat M. A., Pomar V., Coll P., Miralles P., Moreno S., Iribarren J. A., Ibarguren M., Aldamiz T., Rickenbach M., Sagette M., Post F. A., Miller R. F., Chapman A., Dockrell D., Wilkins E., Cooke G., Ainsworth J., Macallen D., Dhar J., Vora N., Mullaney S., Kegg S., Kyselyova G., Mansfeld, M, Skrahina, A, Shepherd, L, Schultze, A, Panteleev, A, Miller, R, Miro, J, Zeltina, I, Tetradov, S, Furrer, H, Kirk, O, Grzeszczuk, A, Bolokadze, N, Matteelli, A, Post, F, Lundgren, J, Mocroft, A, Efsen, A, Podlekareva, D, Losso, M, Toibaro, J, Palmero, D, Bartoletti, B, E., W, Gear, O, Messina, O, Michans, M, Laplume, H, David, D, Marson, C, Scapelatto, F, Dalessandro, D, Lupo, S, Costilla Campero, G, Herbst, M, Remondegui, C, Elias, C, Karpov, I, Vassilenko, A, Skrahina, E, Skrahin, A, Zalutskya, A, Kondratenko, O, Mitsura, V, Bondarenko, V, Suetnov, O, Paduto, D, Dewit, S, Payen, M, Noscoi, C, Kabeya, K, M., W, Cortes, C, Obel, N, Kronborg, G, Iljna, V, Kummik, T, Bryand, M, Dabis, F, Lanchava, N, Bablishvili, N, Goginashvili, L, Mikiashvili, L, Mshvidobadze, K, Girardi, E, Di Biagio, A, Apostoli, A, Barzoni, S, Lapadula, G, Purgatorio, M, Carbonara, S, Rozentale, B, Janushkevich, I, Caplinskas, S, Kancauskienne, Z, Caplinskienne, I, Crabtree, B, Pina, A, Madero, J, Mosqueda, J, Villanueva, J, Bura, M, Garlicki, A, Inglot, M, Knysz, B, Kozlowska, J, Loster, J, Mularska, E, Podlasin, R, Thompson, M, Wiercinska-Drapalo, A, Duiculescu, D, Rakhmanova, A, Yakovlev, A, Turkalova, A, Vlasova, Y, Trotimora, T, Borodulina, E, Chumanova, L, Mashkova, Y, Cayla, J, Moreno, A, Millet, J, Orcau, A, Fina, L, del Bano, L, Roldan, L, Romero, A, Martinez, J, Manzardo, C, Gonzalez, J, Tudo, G, Knobel, H, Sanchez, F, Salvado, M, Curran, A, Tortola, M, Pozamczer, D, Saumoy, M, Alcaide, F, Martinez-Lacasa, X, Cuchi, E, Sambeat, M, Pomar, V, Coll, P, Miralles, P, Moreno, S, Iribarren, J, Ibarguren, M, Aldamiz, T, Rickenbach, M, Sagette, M, Chapman, A, Dockrell, D, Wilkins, E, Cooke, G, Ainsworth, J, Macallen, D, Dhar, J, Vora, N, Mullaney, S, Kegg, S, Kyselyova, G, Mansfeld M., Skrahina A., Shepherd L., Schultze A., Panteleev A., Miller R., Miro J., Zeltina I., Tetradov S., Furrer H., Kirk O., Grzeszczuk A., Bolokadze N., Matteelli A., Post F., Lundgren J., Mocroft A., Efsen A., Podlekareva D., Losso M. H., Toibaro J. J., Palmero D., Bartoletti B. J., E. Warley, Gear O., Messina O. G., Michans M., Laplume H., David D., Marson C., Scapelatto F. P., Dalessandro D., Lupo S., Costilla Campero G., Herbst M., Remondegui C., Elias C., Karpov I., Vassilenko A., Skrahina E., Skrahin A., Zalutskya A., Kondratenko O., Mitsura V., Bondarenko V., Suetnov O., Paduto D., Dewit S., Payen M. C., Noscoi C., Kabeya K., M. Wolff, Cortes C., Obel N., Kronborg G., Iljna V., Kummik T., Bryand M., Dabis F., Lanchava N., Bablishvili N., Goginashvili L., Mikiashvili L., Mshvidobadze K., Girardi E., Di Biagio A., Apostoli A., Barzoni S., Lapadula G., Purgatorio M., Carbonara S., Rozentale B., Janushkevich I., Caplinskas S., Kancauskienne Z., Caplinskienne I., Crabtree B., Pina A., Madero J. S., Mosqueda J., Villanueva J. A., Bura M., Garlicki A., Inglot M., Knysz B., Kozlowska J., Loster J., Mularska E., Podlasin R., Thompson M., Wiercinska-Drapalo A., Duiculescu D., Rakhmanova A., Yakovlev A., Turkalova A., Vlasova Y., Trotimora T., Borodulina E., Chumanova L., Mashkova Y., Miro J. M., Cayla J. A., Moreno A., Millet J. P., Orcau A., Fina L., del Bano L., Roldan L. L., Romero A., Martinez J. A., Manzardo C., Gonzalez J., Tudo G., Knobel H., Sanchez F., Salvado M., Curran A., Tortola M. T., Pozamczer D., Saumoy M., Alcaide F., Martinez-Lacasa X., Cuchi E., Sambeat M. A., Pomar V., Coll P., Miralles P., Moreno S., Iribarren J. A., Ibarguren M., Aldamiz T., Rickenbach M., Sagette M., Post F. A., Miller R. F., Chapman A., Dockrell D., Wilkins E., Cooke G., Ainsworth J., Macallen D., Dhar J., Vora N., Mullaney S., Kegg S., and Kyselyova G.

Abstract

Objectives: The aim of the study was to investigate the organization and delivery of HIV and tuberculosis (TB) health care and to analyse potential differences between treatment centres in Eastern (EE) and Western Europe (WE). Methods: Thirty-eight European HIV and TB treatment centres participating in the TB:HIV study within EuroCoord completed a survey on health care management for coinfected patients in 2013 (EE: 17 respondents; WE:21; 76% of all TB:HIV centres). Descriptive statistics were obtained for regional comparisons. The reported data on health care strategies were compared with actual clinical practice at patient level via data derived from the TB:HIV study. Results: Respondent centres in EE comprised: Belarus (n=3), Estonia (1), Georgia (1), Latvia (1), Lithuania (1), Poland (4), Romania (1), the Russian Federation (4) and Ukraine (1); those in WE comprised: Belgium (1), Denmark (1), France (1), Italy (7), Spain (2), Switzerland (1) and UK (8). Compared with WE, treatment of HIV and TB in EE are less often located at the same site (47% in EE versus 100% in WE; P<0.001) and less often provided by the same doctors (41% versus 90%, respectively; P=0.002), whereas regular screening of HIV-infected patients for TB (80% versus 40%, respectively; P=0.037) and directly observed treatment (88% versus 20%, respectively; P<0.001) were more common in EE. The reported availability of rifabutin and second- and third-line anti-TB drugs was lower, and opioid substitution therapy (OST) was available at fewer centres in EE compared with WE (53% versus 100%, respectively; P<0.001). Conclusions: Major differences exist between EE and WE in relation to the organization and delivery of health care for HIV/TB-coinfected patients and the availability of anti-TB drugs and OST. Significant discrepancies between reported and actual clinical practices were found in EE.

Published
2015

6. Major differences in organization and availability of health care and medicines for HIV/TB coinfected patients across Europe

Author

Mansfeld M., Skrahina A., Shepherd L., Schultze A., Panteleev A., Miller R., Miro J., Zeltina I., Tetradov S., Furrer H., Kirk O., Grzeszczuk A., Bolokadze N., Matteelli A., Post F., Lundgren J., Mocroft A., Efsen A., Podlekareva D., Losso M. H., Toibaro J. J., Palmero D., Bartoletti B. J., E. Warley, Gear O., Messina O. G., Michans M., Laplume H., David D., Marson C., Scapelatto F. P., Dalessandro D., Lupo S., Costilla Campero G., Herbst M., Remondegui C., Elias C., Karpov I., Vassilenko A., Skrahina E., Skrahin A., Zalutskya A., Kondratenko O., Mitsura V., Bondarenko V., Suetnov O., Paduto D., Dewit S., Payen M. C., Noscoi C., Kabeya K., M. Wolff, Cortes C., Obel N., Kronborg G., Iljna V., Kummik T., Bryand M., Dabis F., Lanchava N., Bablishvili N., Goginashvili L., Mikiashvili L., Mshvidobadze K., Girardi E., Di Biagio A., Apostoli A., Barzoni S., Lapadula G., Purgatorio M., Carbonara S., Rozentale B., Janushkevich I., Caplinskas S., Kancauskienne Z., Caplinskienne I., Crabtree B., Pina A., Madero J. S., Mosqueda J., Villanueva J. A., Bura M., Garlicki A., Inglot M., Knysz B., Kozlowska J., Loster J., Mularska E., Podlasin R., Thompson M., Wiercinska-Drapalo A., Duiculescu D., Rakhmanova A., Yakovlev A., Turkalova A., Vlasova Y., Trotimora T., Borodulina E., Chumanova L., Mashkova Y., Miro J. M., Cayla J. A., Moreno A., Millet J. P., Orcau A., Fina L., del Bano L., Roldan L. L., Romero A., Martinez J. A., Manzardo C., Gonzalez J., Tudo G., Knobel H., Sanchez F., Salvado M., Curran A., Tortola M. T., Pozamczer D., Saumoy M., Alcaide F., Martinez-Lacasa X., Cuchi E., Sambeat M. A., Pomar V., Coll P., Miralles P., Moreno S., Iribarren J. A., Ibarguren M., Aldamiz T., Rickenbach M., Sagette M., Post F. A., Miller R. F., Chapman A., Dockrell D., Wilkins E., Cooke G., Ainsworth J., Macallen D., Dhar J., Vora N., Mullaney S., Kegg S., Kyselyova G., Mansfeld, M, Skrahina, A, Shepherd, L, Schultze, A, Panteleev, A, Miller, R, Miro, J, Zeltina, I, Tetradov, S, Furrer, H, Kirk, O, Grzeszczuk, A, Bolokadze, N, Matteelli, A, Post, F, Lundgren, J, Mocroft, A, Efsen, A, Podlekareva, D, Losso, M, Toibaro, J, Palmero, D, Bartoletti, B, E., W, Gear, O, Messina, O, Michans, M, Laplume, H, David, D, Marson, C, Scapelatto, F, Dalessandro, D, Lupo, S, Costilla Campero, G, Herbst, M, Remondegui, C, Elias, C, Karpov, I, Vassilenko, A, Skrahina, E, Skrahin, A, Zalutskya, A, Kondratenko, O, Mitsura, V, Bondarenko, V, Suetnov, O, Paduto, D, Dewit, S, Payen, M, Noscoi, C, Kabeya, K, M., W, Cortes, C, Obel, N, Kronborg, G, Iljna, V, Kummik, T, Bryand, M, Dabis, F, Lanchava, N, Bablishvili, N, Goginashvili, L, Mikiashvili, L, Mshvidobadze, K, Girardi, E, Di Biagio, A, Apostoli, A, Barzoni, S, Lapadula, G, Purgatorio, M, Carbonara, S, Rozentale, B, Janushkevich, I, Caplinskas, S, Kancauskienne, Z, Caplinskienne, I, Crabtree, B, Pina, A, Madero, J, Mosqueda, J, Villanueva, J, Bura, M, Garlicki, A, Inglot, M, Knysz, B, Kozlowska, J, Loster, J, Mularska, E, Podlasin, R, Thompson, M, Wiercinska-Drapalo, A, Duiculescu, D, Rakhmanova, A, Yakovlev, A, Turkalova, A, Vlasova, Y, Trotimora, T, Borodulina, E, Chumanova, L, Mashkova, Y, Cayla, J, Moreno, A, Millet, J, Orcau, A, Fina, L, del Bano, L, Roldan, L, Romero, A, Martinez, J, Manzardo, C, Gonzalez, J, Tudo, G, Knobel, H, Sanchez, F, Salvado, M, Curran, A, Tortola, M, Pozamczer, D, Saumoy, M, Alcaide, F, Martinez-Lacasa, X, Cuchi, E, Sambeat, M, Pomar, V, Coll, P, Miralles, P, Moreno, S, Iribarren, J, Ibarguren, M, Aldamiz, T, Rickenbach, M, Sagette, M, Chapman, A, Dockrell, D, Wilkins, E, Cooke, G, Ainsworth, J, Macallen, D, Dhar, J, Vora, N, Mullaney, S, Kegg, S, and Kyselyova, G

Subjects
Tuberculosi, Coinfection, Health Policy, Antitubercular Agents, HIV, 1103 Clinical Sciences, HIV Infections, Eastern, Health Surveys, Article, Europe, Infectious Diseases, Cross-Sectional Studies, Rifabutin, Delivery of health care, Integrated, Tuberculosis, Europe, Eastern, Humans, Opiate Substitution Treatment, Pharmacology (medical), Virology, 610 Medicine & health
Abstract

Objectives: The aim of the study was to investigate the organization and delivery of HIV and tuberculosis (TB) health care and to analyse potential differences between treatment centres in Eastern (EE) and Western Europe (WE). Methods: Thirty-eight European HIV and TB treatment centres participating in the TB:HIV study within EuroCoord completed a survey on health care management for coinfected patients in 2013 (EE: 17 respondents; WE:21; 76% of all TB:HIV centres). Descriptive statistics were obtained for regional comparisons. The reported data on health care strategies were compared with actual clinical practice at patient level via data derived from the TB:HIV study. Results: Respondent centres in EE comprised: Belarus (n=3), Estonia (1), Georgia (1), Latvia (1), Lithuania (1), Poland (4), Romania (1), the Russian Federation (4) and Ukraine (1); those in WE comprised: Belgium (1), Denmark (1), France (1), Italy (7), Spain (2), Switzerland (1) and UK (8). Compared with WE, treatment of HIV and TB in EE are less often located at the same site (47% in EE versus 100% in WE; P

Published
2015

10. Impaired fitness of Mycobacterium tuberculosis resistant isolates in a cell culture model of murine macrophages

Author

Rey-Jurado, E., primary, Tudo, G., additional, Borrell, S., additional, Alcaide, F., additional, Coll, P., additional, Espanol, M., additional, Martin-Casabona, N., additional, Mick, V., additional, Montemayor, M., additional, Moure, R., additional, Salvado, M., additional, Vicente, E., additional, and Gonzalez-Martin, J., additional

Published
2011
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11. Characterization of mutations in streptomycin-resistant Mycobacterium tuberculosis clinical isolates in the area of Barcelona

Author

Tudo, G., primary, Rey, E., additional, Borrell, S., additional, Alcaide, F., additional, Codina, G., additional, Coll, P., additional, Martin-Casabona, N., additional, Montemayor, M., additional, Moure, R., additional, Orcau, A., additional, Salvado, M., additional, Vicente, E., additional, and Gonzalez-Martin, J., additional

Published
2010
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13. Comorbidity and emergency visits explain home care patients hospital admissions | Comorbilidad y visitas a urgencias explican los ingresos hospitalarios de los pacientes incluidos en programas de atención domiciliaria

Author

Gené Badia, J., Hidalgo García, A., Contel Segura, J. C., Borràs Santos, A., Carlos Ascaso Terren, Piñeiro González, M., Ortiz Molina, J., Martín Royo, J., Gonzalez Martinez, S., Camprubí Casellas, Ma D., Cegri Lombardo, F., Limón Ramírez, E., Aranzana Martínez, A., Heras Tebar, A., Noguera Rodríguez, R., Oliver Olius, A., Rivas Zuazo, S., Porta Borges, M., Adell Aguiló, N., Borrell Muñoz, M., Rodríguez, R. N., Riera, N., Polis, S. V., Martín, S. D., Gené, J., Martin, A. B. I. J., Haro, S. P., Arderiu, E. S., Ubiedo, Ma A. M., León, S. P., Rosalen, A. P., González, M. N., Artigas, N. G., Ruano, N. S., Planas, N. G., Huertas, I. C., López, R. S., Amat, G., Navarro, B. V., Hosta, M. M., Soldevila, J. C., Soriano, I. B., Docon, A. H., Vilaseca, J. M., Molina, J. O., Martinez, S. G., Sotoca, J. M., Almirall, A. S., Pascual, I. M., Navas, G. P., Martos, Ma J. G., García, P. A., Moliner, E. M., Sas, S. S. M., Salami, D. C., Esteban, Ma L. M., Beuter, B. D. A., Poyato, M. L., Asensio, Ma L. S., Chillida, S. B., Rodríguez, A. M., Fusté, S. C., Cucurny, A. Ma P. D. M., Muñoz, M. B., García, M. P. A., Sánchez, P. M., Pallarés, M. P. -M, Baldrich, M. C., Viñas, R. B., Ramírez, B. A., Fusalba, A. R., Espinosa, J. A., Schmab, A. P., Baró, T. M., Pujol, L. E., Santandreu, C. N., Monfort, G. M., Olius, A. O., Borges, M. P., Zuazo, S. R., Arcos, C. A., Bastardes, C. C., Solsona, I. H., Gaitero, C. M., Del Valle, S. R., Villuendas, A. S., Arus, M. S., López, C. V., López, C. Z., Casas, R. B., Marco, G. P., Casado, M. S., Santamaría, M. G., González, Ma C. G., Tutusaus, I. C., Juliano, F. D., Balasch, J., Martinez, R. Ma A., Elizondo, E. A., Ciordia, B. A., Godia, J. L. C., Rivero, J. C., Ibáñez, B. D. M., Ruiz, F. J. G., González, E. S., Miguel, L. G., Manrique, P. N., Saiz, G. M., Vergel, R. F., Maña, M. P., Sánchez, C. C., Andreu, L. C., Mendoza, R. D., Robledo, S. C., García, D. G., Castillo, Á S., Sesma, F. F., Suárez, E. Q., Piquero, H. P., García, C. P., López, P. S., Marsal, A. P., Jacas, Ma C. S., Fernández, Ma E. B., López, S. Á, Antón, I. E., Casamada, N., Llauradó, R. M., Mata, J., Colominas, J., Gómez, A., Bargalló, G., Mora, E. V., González, I. A., Ferrer, O. M., Carrión, F. G., Carrión, B. G., Font, M. M., Juan, M. P., Cuxart, J. G., Castro, E. D., Canovas, A. N., Ferrer, J. L. G., Perea, S. G., González, I. V., Pujolras, T. A., Nogueras, R. G., Morillo, E. V., Lorenzo, P. F., Gelabert, J. T., Mifsud, A. A., Gutiérrez, M. D. C. G., Lasheras, M., Fernandez, E. A., López, F., Yánez, R. F., Brau, C. V., Soria, C. G., Sánchez, G. S., Salafranca, R. Ma F., Ortiz, M. I. P., Recio, P. E., Cantó, A., Rebullida, M. C., Sillero, L., Esteve, M., Rodrigo, F., Lasaosa, L., Lombardo, F. C., Martínez, A. A., Pinadell, N. A., Schornstein, M. D. O., Carretero, M. M., Enguidanos, J. P., Gómez, A. M., Miralles, C. B., Osuna, G. B., Ellacuria, M. P., Villena, I. G., Santiago, Y. C., Mayor, I. T., González, P. M., Pujol, J. A., Gallart, E. B., Ortega, M. T. T., Agorritz, R. U., Reig, N. R., Dausa, M. L. D., García, A. J. B., Jiménez, A. D., García, R. C., Aponte, T. L., Reig, C. V., Barbero, T. I., Soriano, L. M., Gomez, C. U., Bellera, L. R., Pañella, S. C., Arévalo, A., Palies, A. R. G., Rocarias, M. G., Bueno, J. L. L., Olivera, L. D., Rosselló, Ma A. L., Jiménez, Ma A. P., Alborch, J. F., Canal, Ma T. F., Pérez, Ma P. H., Priego, D. G., Salvans, Ma C. Q., Villanueva, C. F., Martín, Ma L. M., Radial, Ma A. M. D. E., Ibáñez, M. C., Moreno, P. V., Cortes, T. P., Beltrán, M. B., Caba, P. M., Exposito, A. B., Bellido, E. D., Alonso, E. B., Baena, M. M., Andres, E. C., Cerdà, N. B., Aguadé, M. M., Busquets, A. R., Piñeiro, M. C. S., Salla, E. N., Gual, R. P., Ricart, A. J., Pujol, N. R., Vidal, E. F., Rodríguez, M. B. S., Vilella, R. A., Delcor, C. M., García, M. D. S., Bartroli, M. R., Arcos, E. G., Larroy, E. L., Matas, R. M., Martinez, P. G., Novella, R. M., Freixanet, C. V., Pipió, C. M., Albí, N., Nogués, J., Martinez, Ma J. 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14. Oleoyl coenzyme A regulates interaction of transcriptional regulator RaaS (Rv1219c) with DNA in mycobacteria.

Author

Turapov O, Waddell SJ, Burke B, Glenn S, Sarybaeva AA, Tudo G, Labesse G, Young DI, Young M, Andrew PW, Butcher PD, Cohen-Gonsaud M, and Mukamolova GV

Subjects
Acyl Coenzyme A chemistry, Amino Acid Sequence, Bacterial Proteins genetics, Binding Sites genetics, DNA, Bacterial genetics, Fluorescence Polarization, Gene Expression Regulation, Bacterial drug effects, Microbial Viability drug effects, Microbial Viability genetics, Molecular Sequence Data, Molecular Structure, Mutation, Mycobacterium genetics, Mycobacterium bovis genetics, Mycobacterium bovis metabolism, Mycobacterium tuberculosis genetics, Mycobacterium tuberculosis metabolism, Oleic Acid pharmacology, Palmitoyl Coenzyme A chemistry, Palmitoyl Coenzyme A metabolism, Protein Binding, Reverse Transcriptase Polymerase Chain Reaction, Sequence Homology, Amino Acid, Transcriptome drug effects, Transcriptome genetics, Acyl Coenzyme A metabolism, Bacterial Proteins metabolism, DNA, Bacterial metabolism, Mycobacterium metabolism
Abstract

We have recently shown that RaaS (regulator of antimicrobial-assisted survival), encoded by Rv1219c in Mycobacterium tuberculosis and by bcg&#95;1279c in Mycobacterium bovis bacillus Calmette-Guérin, plays an important role in mycobacterial survival in prolonged stationary phase and during murine infection. Here, we demonstrate that long chain acyl-CoA derivatives (oleoyl-CoA and, to lesser extent, palmitoyl-CoA) modulate RaaS binding to DNA and expression of the downstream genes that encode ATP-dependent efflux pumps. Moreover, exogenously added oleic acid influences RaaS-mediated mycobacterial improvement of survival and expression of the RaaS regulon. Our data suggest that long chain acyl-CoA derivatives serve as biological indicators of the bacterial metabolic state. Dysregulation of efflux pumps can be used to eliminate non-growing mycobacteria., (© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.)

Published
2014
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15. Antimicrobial treatment improves mycobacterial survival in nonpermissive growth conditions.

Author

Turapov O, Waddell SJ, Burke B, Glenn S, Sarybaeva AA, Tudo G, Labesse G, Young DI, Young M, Andrew PW, Butcher PD, Cohen-Gonsaud M, and Mukamolova GV

Subjects
Animals, Cell Line, Electrophoretic Mobility Shift Assay, Fluorescence Polarization, Humans, Mice, Mycobacterium bovis metabolism, Mycobacterium tuberculosis metabolism, Anti-Infective Agents pharmacology, Mycobacterium bovis drug effects, Mycobacterium tuberculosis drug effects
Abstract

Antimicrobials targeting cell wall biosynthesis are generally considered inactive against nonreplicating bacteria. Paradoxically, we found that under nonpermissive growth conditions, exposure of Mycobacterium bovis BCG bacilli to such antimicrobials enhanced their survival. We identified a transcriptional regulator, RaaS (for regulator of antimicrobial-assisted survival), encoded by bcg1279 (rv1219c) as being responsible for the observed phenomenon. Induction of this transcriptional regulator resulted in reduced expression of specific ATP-dependent efflux pumps and promoted long-term survival of mycobacteria, while its deletion accelerated bacterial death under nonpermissive growth conditions in vitro and during macrophage or mouse infection. These findings have implications for the design of antimicrobial drug combination therapies for persistent infectious diseases, such as tuberculosis.

Published
2014
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16. Rare diagnosis of nodular lymphangitis caused by Mycobacterium marinum: MDCT imaging findings.

Author

Tomas X, Pedrosa M, Soriano A, Zboromyrska Y, Tudo G, Garcia S, and Pomes J

Abstract

Mycobacterium marinum is an atypical mycobacterium that usually causes a solitary nodule on the hand ("fish tank granuloma") or less commonly, secondary erythematous channels and nodules spread along lymphatic drainage of the extremity, mimicking sporothricoid skin lesions of nodular lymphangitis. This report presents a case of this rare entity, a nodular lymphangitis caused by Mycobacterium marinum. Multidetector computed tomography (MDCT) imaging was very useful in determining the morphology (cellulitis with a few small subcutaneous nodules and channels) and the extension of the lesion.

Published
2014
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