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1. Mortality and its association with chronic alcohol-related diseases in patients admitted to the emergency department for acute alcoholic intoxication: retrospective cohort study

Author

Palmese, Francesco, Bonavita, Maria Elena, Pompili, Enrico, Migliano, Maria Teresa, Reggidori, Nicola, Di Stefano, Cecilia, Grieco, Marta, Colazzo, Stefano, Tufoni, Manuel, Baldassarre, Maurizio, Caraceni, Paolo, Foschi, Francesco Giuseppe, Giostra, Fabrizio, Farina, Gabriele, Del Toro, Rossella, Bedogni, Giorgio, and Domenicali, Marco

Published
2023
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2. PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis

Author

Maschmeier, Miriam, Semela, David, Elkrief, Laure, Elsharkawy, Ahmed, Tornai, Tamas, Tornai, Istvan, Altorjay, Istvan, Antognoli, Agnese, Baldassarre, Maurizio, Gagliardi, Martina, Bertoli, Eleonora, Mareso, Sara, Brocca, Alessandra, Campion, Daniela, Saracco, Giorgio Maria, Rizzo, Martina, Lehmann, Jennifer, Pohlmann, Alessandra, Brol, Maximilian J., Chang, Johannes, Schierwagen, Robert, Solà, Elsa, Amari, Nesrine, Rodriguez, Miguel, Nevens, Frederik, Clemente, Ana, Janicko, Martin, Markwardt, Daniel, Mandorfer, Mattias, Welsch, Christoph, Welzel, Tanja M., Ciraci, Emanuela, Patel, Vish, Ripoll, Cristina, Herber, Adam, Horn, Paul, Bendtsen, Flemming, Gluud, Lise Lotte, Schaapman, Jelte, Riggio, Oliviero, Rainer, Florian, Moritz, Jörg Tobiasch, Mesquita, Mónica, Alvarado-Tapias, Edilmar, Akpata, Osagie, Aamann, Luise, Samuel, Didier, Tresson, Sylvie, Strnad, Pavel, Amathieu, Roland, Simón-Talero, Macarena, Smits, Francois, van den Ende, Natalie, Martinez, Javier, Garcia, Rita, Rupprechter, Harald, Engelmann, Cornelius, Özdogan, Osman Cavit, Trebicka, Jonel, Fernandez, Javier, Papp, Maria, Caraceni, Paolo, Laleman, Wim, Gambino, Carmine, Giovo, Ilaria, Uschner, Frank Erhard, Jansen, Christian, Jimenez, Cesar, Mookerjee, Rajeshwar, Gustot, Thierry, Albillos, Agustin, Bañares, Rafael, Jarcuska, Peter, Steib, Christian, Reiberger, Thomas, Acevedo, Juan, Gatti, Pietro, Shawcross, Debbie L., Zeuzem, Stefan, Zipprich, Alexander, Piano, Salvatore, Berg, Thomas, Bruns, Tony, Danielsen, Karen Vagner, Coenraad, Minneke, Merli, Manuela, Stauber, Rudolf, Zoller, Heinz, Ramos, José Presa, Solé, Cristina, Soriano, Germán, de Gottardi, Andrea, Gronbaek, Henning, Saliba, Faouzi, Trautwein, Christian, Kani, Haluk Tarik, Francque, Sven, Ryder, Stephen, Nahon, Pierre, Romero-Gomez, Manuel, Van Vlierberghe, Hans, Francoz, Claire, Manns, Michael, Garcia-Lopez, Elisabet, Tufoni, Manuel, Amoros, Alex, Pavesi, Marco, Sanchez, Cristina, Praktiknjo, Michael, Curto, Anna, Pitarch, Carla, Putignano, Antonella, Moreno, Esau, Bernal, William, Aguilar, Ferran, Clària, Joan, Ponzo, Paola, Vitalis, Zsuzsanna, Zaccherini, Giacomo, Balogh, Boglarka, Gerbes, Alexander, Vargas, Victor, Alessandria, Carlo, Bernardi, Mauro, Ginès, Pere, Moreau, Richard, Angeli, Paolo, Jalan, Rajiv, and Arroyo, Vicente

Published
2021
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3. On-treatment serum albumin level can guide long-term treatment in patients with cirrhosis and uncomplicated ascites

Author

Domenicali, Marco, Giannone, Ferdinando A., Antognoli, Agnese, Merli, Manuela, Pasquale, Chiara, Gioia, Stefania, Fasolato, Silvano, Sticca, Antonietta, Campion, Daniela, Risso, Alessandro, Saracco, Giorgio M., Prestianni, Loredana, Fidone, Federica, Maiorca, Daniela, Rizzotto, Agostino, Cappa, Federica Mirici, Lanzi, Arianna, Neri, Elga, Visani, Anna, Mastroianni, Antonio, Perricone, Giovanni, Alberti, Alberto B., Cesarini, Lucia, Mazzarelli, Chiara, Vangeli, Marcello, Viganò, Raffaella, Marzioni, Marco, Capretti, Francesca, Kostandini, Alba, Magini, Giulia, Colpani, Maria, Gabbani, Tommaso, Marsico, Maria, Zappimbulso, Marianna, Petruzzi, Josè, Calvaruso, Vincenza, Parrella, Giovanni, Caporaso, Nicola, Auriemma, Francesco, Guarino, Maria, Pugliese, Fabio, Tortora, Annalisa, Leo, Pietro, Angelico, Mario, De Leonardis, Francesco, Pecchioli, Alessandra, Rossi, Piera, Raimondo, Giovanni, Cacciola, Irene, Elia, Gianfranco, Negri, Elisa, Dallio, Marcello, Loguercio, Carmelina, Federico, Alessandro, Conte, Dario, Massironi, Sara, Natascia Celli, Giorgio Ballardini, Rendina, Maria, Bringiotti, Roberto, Castellaneta, Nicola Maurizio, Salerno, Francesco, Boccia, Sergio, Guarisco, Riccardo, Galioto, Alessandra, Cavallin, Marta, Andrealli, Alida, Caraceni, Paolo, Tufoni, Manuel, Zaccherini, Giacomo, Riggio, Oliviero, Angeli, Paolo, Alessandria, Carlo, Neri, Sergio, Foschi, Francesco G., Levantesi, Fabio, Airoldi, Aldo, Simone, Loredana, Svegliati-Baroni, Gianluca, Fagiuoli, Stefano, Laffi, Giacomo, Cozzolongo, Raffaele, Di Marco, Vito, Sangiovanni, Vincenzo, Morisco, Filomena, Toniutto, Pierluigi, Gasbarrini, Antonio, De Marco, Rosanna, Piano, Salvatore, Nardelli, Silvia, Elia, Chiara, Roncadori, Andrea, Baldassarre, Maurizio, and Bernardi, Mauro

Published
2021
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4. The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology

Author

Maschmeier, Miriam, Semela, David, Elkrief, Laure, Elsharkawy, Ahmed, Tornai, Tamas, Tornai, Istvan, Altorjay, Istvan, Antognoli, Agnese, Baldassarre, Maurizio, Gagliardi, Martina, Bertoli, Eleonora, Mareso, Sara, Brocca, Alessandra, Campion, Daniela, Saracco, Giorgio Maria, Rizzo, Martina, Lehmann, Jennifer, Pohlmann, Alessandra, Praktiknjo, Michael, Schierwagen, Robert, Solà, Elsa, Amari, Nesrine, Rodriguez, Miguel, Nevens, Frederik, Clemente, Ana, Jarcuska, Peter, Gerbes, Alexander, Mandorfer, Mattias, Welsch, Christoph, Ciraci, Emanuela, Patel, Vish, Ripoll, Cristina, Herber, Adam, Horn, Paul, Danielsen, Karen Vagner, Gluud, Lise Lotte, Schaapman, Jelte, Riggio, Oliviero, Rainer, Florian, Moritz, Jörg Tobiasch, Mesquita, Mónica, Alvarado-Tapias, Edilmar, Akpata, Osagie, Lykke Eriksen, Peter, Samuel, Didier, Tresson, Sylvie, Strnad, Pavel, Amathieu, Roland, Simón-Talero, Macarena, Smits, Francois, van den Ende, Natalie, Martinez, Javier, Garcia, Rita, Markwardt, Daniel, Rupprechter, Harald, Engelmann, Cornelius, Trebicka, Jonel, Fernandez, Javier, Papp, Maria, Caraceni, Paolo, Laleman, Wim, Gambino, Carmine, Giovo, Ilaria, Uschner, Frank Erhard, Jimenez, Cesar, Mookerjee, Rajeshwar, Gustot, Thierry, Albillos, Agustin, Bañares, Rafael, Janicko, Martin, Steib, Christian, Reiberger, Thomas, Acevedo, Juan, Gatti, Pietro, Bernal, William, Zeuzem, Stefan, Zipprich, Alexander, Piano, Salvatore, Berg, Thomas, Bruns, Tony, Bendtsen, Flemming, Coenraad, Minneke, Merli, Manuela, Stauber, Rudolf, Zoller, Heinz, Ramos, José Presa, Solè, Cristina, Soriano, Germán, de Gottardi, Andrea, Gronbaek, Henning, Saliba, Faouzi, Trautwein, Christian, Özdogan, Osman Cavit, Francque, Sven, Ryder, Stephen, Nahon, Pierre, Romero-Gomez, Manuel, Van Vlierberghe, Hans, Francoz, Claire, Manns, Michael, Garcia, Elisabet, Tufoni, Manuel, Amoros, Alex, Pavesi, Marco, Sanchez, Cristina, Curto, Anna, Pitarch, Carla, Putignano, Antonella, Moreno, Esau, Shawcross, Debbie, Aguilar, Ferran, Clària, Joan, Ponzo, Paola, Jansen, Christian, Vitalis, Zsuzsanna, Zaccherini, Giacomo, Balogh, Boglarka, Vargas, Victor, Montagnese, Sara, Alessandria, Carlo, Bernardi, Mauro, Ginès, Pere, Jalan, Rajiv, Moreau, Richard, Angeli, Paolo, and Arroyo, Vicente

Published
2020
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7. Long-term albumin administration in decompensated cirrhosis (ANSWER): an open-label randomised trial

Author

Domenicali, Marco, Giannone, Ferdinando A, Merli, Manuela, Gioia, Stefania, Fasolato, Silvano, Sticca, Antonietta, Campion, Daniela, Risso, Alessandro, Saracco, Giorgio M, Maiorca, Daniela, Rizzotto, Agostino, Lanzi, Arianna, Neri, Elga, Visani, Anna, Mastroianni, Antonio, Alberti, Alberto B, Mazzarelli, Chiara, Vangeli, Marcello, Marzioni, Marco, Capretti, Francesca, Kostandini, Alba, Magini, Giulia, Colpani, Maria, Laffi, Giacomo, Gabbani, Tommaso, Marsico, Maria, Zappimbulso, Marianna, Petruzzi, Josè, Calvaruso, Vincenza, Parrella, Giovanni, Caporaso, Nicola, Auriemma, Francesco, Guarino, Maria, Pugliese, Fabio, Gasbarrini, Antonio, Leo, Pietro, De Leonardis, Francesco, Pecchioli, Alessandra, Rossi, Piera, Raimondo, Giovanni, Negri, Elisa, Dallio, Marcello, Loguercio, Carmelina, Conte, Dario, Celli, Natascia, Bringiotti, Roberto, Castellaneta, Nicola M, Salerno, Francesco, Caraceni, Paolo, Riggio, Oliviero, Angeli, Paolo, Alessandria, Carlo, Neri, Sergio, Foschi, Francesco G, Levantesi, Fabio, Airoldi, Aldo, Boccia, Sergio, Svegliati-Baroni, Gianluca, Fagiuoli, Stefano, Romanelli, Roberto G, Cozzolongo, Raffaele, Di Marco, Vito, Sangiovanni, Vincenzo, Morisco, Filomena, Toniutto, Pierluigi, Tortora, Annalisa, De Marco, Rosanna, Angelico, Mario, Cacciola, Irene, Elia, Gianfranco, Federico, Alessandro, Massironi, Sara, Guarisco, Riccardo, Galioto, Alessandra, Ballardini, Giorgio, Rendina, Maria, Nardelli, Silvia, Piano, Salvatore, Elia, Chiara, Prestianni, Loredana, Cappa, Federica Mirici, Cesarini, Lucia, Simone, Loredana, Pasquale, Chiara, Cavallin, Marta, Andrealli, Alida, Fidone, Federica, Ruggeri, Matteo, Roncadori, Andrea, Baldassarre, Maurizio, Tufoni, Manuel, Zaccherini, Giacomo, and Bernardi, Mauro

Published
2018
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9. Low hemoglobin level Predicts early hospital readmission in patients with cirrhosis and acute decompensation

Author

Pompili, Enrico, primary, Baldassarre, Maurizio, additional, Zaccherini, Giacomo, additional, Tufoni, Manuel, additional, Iannone, Giulia, additional, Pratelli, Dario, additional, Palmese, Francesco, additional, Vizioli, Luca, additional, Faggiano, Chiara, additional, Bedogni, Giorgio, additional, Domenicali, Marco, additional, and Caraceni, Paolo, additional

Published
2023
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10. Mortality and its association with chronic alcohol-related diseases in patients admitted to the emergency department for acute alcoholic intoxication: retrospective cohort study

Author

Palmese, Francesco, primary, Bonavita, Maria Elena, additional, Pompili, Enrico, additional, Migliano, Maria Teresa, additional, Reggidori, Nicola, additional, Di Stefano, Cecilia, additional, Grieco, Marta, additional, Colazzo, Stefano, additional, Tufoni, Manuel, additional, Baldassarre, Maurizio, additional, Caraceni, Paolo, additional, Foschi, Francesco Giuseppe, additional, Giostra, Fabrizio, additional, Farina, Gabriele, additional, Del Toro, Rossella, additional, Bedogni, Giorgio, additional, and Domenicali, Marco, additional

Published
2022
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13. Correction and prevention of hyponatremia in patients with cirrhosis and ascites-post hoc analysis of the ANSWER study database

Author

Zaccherini, Giacomo, primary, Baldassarre, Maurizio, additional, Tufoni, Manuel, additional, Riggio, Oliviero, additional, Angeli, Paolo, additional, Alessandria, Carlo, additional, Neri, Sergio, additional, Foschi, Francesco Giuseppe, additional, Levantesi, Fabio, additional, Airoldi, Aldo, additional, Simone, Loredana, additional, Svegiati-Baroni, Gianluca, additional, Fagiuoli, Stefano, additional, Laffi, Giacomo, additional, Cozzolongo, Raffaele, additional, Di Marco, Vito, additional, Sangiovanni, Vincenzo, additional, Morisco, Filomena, additional, Toniutto, Pierluigi, additional, Tortora, Annalisa, additional, De Marco, Rosanna, additional, Nardelli, Silvia, additional, Piano, Salvatore, additional, Elia, Chiara, additional, Bernardi, Mauro, additional, and Caraceni, Paolo, additional

Published
2022
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14. Correction and prevention of hyponatremia in patients with cirrhosis and ascites-post hoc analysis of the ANSWER study database

Author

Giacomo Zaccherini, Baldassarre, Maurizio, Tufoni, Manuel, Riggio, Oliviero, Angeli, Paolo, Alessandria, Carlo, Neri, Sergio, Foschi, Francesco Giuseppe, Levantesi, Fabio, Airoldi, Aldo, Simone, Loredana, Svegiati-Baroni, Gianluca, Fagiuoli, Stefano, Laffi, Giacomo, Cozzolongo, Raffaele, Di Marco, Vito, Sangiovanni, Vincenzo, Morisco, Filomena, Toniutto, Pierluigi, Tortora, Annalisa, Marco, Rosanna, Nardelli, Silvia, Piano, Salvatore, Elia, Chiara, Bernardi, Mauro, and Caraceni, Paolo

Subjects
Hepatology
Published
2022
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19. Albumin Administration is Efficacious in the Management of Patients with Cirrhosis: A Systematic Review of the Literature

Author

Zaccherini,Giacomo, Tufoni,Manuel, and Bernardi,Mauro

Subjects
Evidence and Research [Hepatic Medicine]
Abstract

Giacomo Zaccherini, Manuel Tufoni, Mauro Bernardi Department of Medical and Surgical Sciences, Alma Mater Studiorum - University of Bologna, Bologna 40138, ItalyCorrespondence: Mauro Bernardi Email mauro.bernardi@unibo.itAbstract: The use of albumin in patients with cirrhosis has been extensively discussed over recent years. Current treatment approaches depend on targeting related complications, aiming to treat and/or prevent circulatory dysfunction, bacterial infections and multi-organ failure. Albumin has been shown to prolong survival and reduce complications in patients with cirrhosis. This review aims to ascertain whether the use of albumin is justified in patients with cirrhosis. A systematic review of randomized controlled trials (RCTs) and meta-analyses evaluating albumin use in patients with cirrhosis published between 1985 and February 2020 was conducted; the quality and risk of bias of the included studies were assessed. In total, 45 RCTs and 10 meta-analyses were included. Based on the included evidence, albumin is superior at preventing and controlling the incidence of cirrhosis complications vs other plasma expanders. Recent studies reported that long-term albumin administration to patients with decompensated cirrhosis improves survival with a 38% reduction in the mortality hazard ratio compared with standard medical treatment alone. Albumin infusions are justified for routine use in patients with cirrhosis, and the use of albumin either alone or in combination with other treatments leads to clinical benefits. Long-term administration of albumin should be considered in some patients.Keywords: albumin, ascites, hepatorenal syndrome, liver cirrhosis, paracentesis, peritonitis

Published
2020

20. PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis

Author

Trebicka, Jonel, Fernandez, Javier, Papp, Maria, Caraceni, Paolo, Laleman, Wim, Gambino, Carmine, Giovo, Ilaria, Uschner, Frank Erhard, Jansen, Christian, Jimenez, Cesar, Mookerjee, Rajeshwar, Gustot, Thierry, Albillos, Agustin, Bañares, Rafael, Jarcuska, Peter, Steib, Christian, Reiberger, Thomas, Acevedo, Juan, Gatti, Pietro, Shawcross, Debbie L., Zeuzem, Stefan, Zipprich, Alexander, Piano, Salvatore, Berg, Thomas, Bruns, Tony, Danielsen, Karen Vagner, Coenraad, Minneke, Merli, Manuela, Stauber, Rudolf, Zoller, Heinz, Ramos, José Presa, Solé, Cristina, Soriano, Germán, de Gottardi, Andrea, Gronbaek, Henning, Saliba, Faouzi, Trautwein, Christian, Kani, Haluk Tarik, Francque, Sven, Ryder, Stephen, Nahon, Pierre, Romero-Gomez, Manuel, Van Vlierberghe, Hans, Francoz, Claire, Manns, Michael, Garcia-Lopez, Elisabet, Tufoni, Manuel, Amoros, Alex, Bendtsen, Flemming, Gluud, Lise Lotte, Trebicka, Jonel, Fernandez, Javier, Papp, Maria, Caraceni, Paolo, Laleman, Wim, Gambino, Carmine, Giovo, Ilaria, Uschner, Frank Erhard, Jansen, Christian, Jimenez, Cesar, Mookerjee, Rajeshwar, Gustot, Thierry, Albillos, Agustin, Bañares, Rafael, Jarcuska, Peter, Steib, Christian, Reiberger, Thomas, Acevedo, Juan, Gatti, Pietro, Shawcross, Debbie L., Zeuzem, Stefan, Zipprich, Alexander, Piano, Salvatore, Berg, Thomas, Bruns, Tony, Danielsen, Karen Vagner, Coenraad, Minneke, Merli, Manuela, Stauber, Rudolf, Zoller, Heinz, Ramos, José Presa, Solé, Cristina, Soriano, Germán, de Gottardi, Andrea, Gronbaek, Henning, Saliba, Faouzi, Trautwein, Christian, Kani, Haluk Tarik, Francque, Sven, Ryder, Stephen, Nahon, Pierre, Romero-Gomez, Manuel, Van Vlierberghe, Hans, Francoz, Claire, Manns, Michael, Garcia-Lopez, Elisabet, Tufoni, Manuel, Amoros, Alex, Bendtsen, Flemming, and Gluud, Lise Lotte

Abstract

Background & Aims: Acute decompensation (AD) of cirrhosis may present without acute-on-chronic liver failure (ACLF) (AD-No ACLF), or with ACLF (AD-ACLF), defined by organ failure(s). Herein, we aimed to analyze and characterize the precipitants leading to both of these AD phenotypes. Methods: The multicenter, prospective, observational PREDICT study (NCT03056612) included 1,273 non-electively hospitalized patients with AD (No ACLF = 1,071; ACLF = 202). Medical history, clinical data and laboratory data were collected at enrolment and during 90-day follow-up, with particular attention given to the following characteristics of precipitants: induction of organ dysfunction or failure, systemic inflammation, chronology, intensity, and relationship to outcome. Results: Among various clinical events, 4 distinct events were precipitants consistently related to AD: proven bacterial infections, severe alcoholic hepatitis, gastrointestinal bleeding with shock and toxic encephalopathy. Among patients with precipitants in the AD-No ACLF cohort and the AD-ACLF cohort (38% and 71%, respectively), almost all (96% and 97%, respectively) showed proven bacterial infection and severe alcoholic hepatitis, either alone or in combination with other events. Survival was similar in patients with proven bacterial infections or severe alcoholic hepatitis in both AD phenotypes. The number of precipitants was associated with significantly increased 90-day mortality and was paralleled by increasing levels of surrogates for systemic inflammation. Importantly, adequate first-line antibiotic treatment of proven bacterial infections was associated with a lower ACLF development rate and lower 90-day mortality. Conclusions: This study identified precipitants that are significantly associated with a distinct clinical course and prognosis in patients with AD. Specific preventive and therapeutic strategies targeting these events may improve outcomes in patients with decompensated cirrhosis. Lay su

Published
2021

21. Determination of Effective Albumin in Patients With Decompensated Cirrhosis: Clinical and Prognostic Implications

Author

Baldassarre, Maurizio, primary, Naldi, Marina, additional, Zaccherini, Giacomo, additional, Bartoletti, Michele, additional, Antognoli, Agnese, additional, Laggetta, Maristella, additional, Gagliardi, Martina, additional, Tufoni, Manuel, additional, Domenicali, Marco, additional, Waterstradt, Katja, additional, Paterini, Paola, additional, Baldan, Anna, additional, Leoni, Simona, additional, Bartolini, Manuela, additional, Viale, Pierluigi, additional, Trevisani, Franco, additional, Bernardi, Mauro, additional, and Caraceni, Paolo, additional

Published
2021
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22. PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis

Author

Trebicka, Jonel, primary, Fernandez, Javier, additional, Papp, Maria, additional, Caraceni, Paolo, additional, Laleman, Wim, additional, Gambino, Carmine, additional, Giovo, Ilaria, additional, Uschner, Frank Erhard, additional, Jansen, Christian, additional, Jimenez, Cesar, additional, Mookerjee, Rajeshwar, additional, Gustot, Thierry, additional, Albillos, Agustin, additional, Bañares, Rafael, additional, Jarcuska, Peter, additional, Steib, Christian, additional, Reiberger, Thomas, additional, Acevedo, Juan, additional, Gatti, Pietro, additional, Shawcross, Debbie L., additional, Zeuzem, Stefan, additional, Zipprich, Alexander, additional, Piano, Salvatore, additional, Berg, Thomas, additional, Bruns, Tony, additional, Danielsen, Karen Vagner, additional, Coenraad, Minneke, additional, Merli, Manuela, additional, Stauber, Rudolf, additional, Zoller, Heinz, additional, Ramos, José Presa, additional, Solé, Cristina, additional, Soriano, Germán, additional, de Gottardi, Andrea, additional, Gronbaek, Henning, additional, Saliba, Faouzi, additional, Trautwein, Christian, additional, Kani, Haluk Tarik, additional, Francque, Sven, additional, Ryder, Stephen, additional, Nahon, Pierre, additional, Romero-Gomez, Manuel, additional, Van Vlierberghe, Hans, additional, Francoz, Claire, additional, Manns, Michael, additional, Garcia-Lopez, Elisabet, additional, Tufoni, Manuel, additional, Amoros, Alex, additional, Pavesi, Marco, additional, Sanchez, Cristina, additional, Praktiknjo, Michael, additional, Curto, Anna, additional, Pitarch, Carla, additional, Putignano, Antonella, additional, Moreno, Esau, additional, Bernal, William, additional, Aguilar, Ferran, additional, Clària, Joan, additional, Ponzo, Paola, additional, Vitalis, Zsuzsanna, additional, Zaccherini, Giacomo, additional, Balogh, Boglarka, additional, Gerbes, Alexander, additional, Vargas, Victor, additional, Alessandria, Carlo, additional, Bernardi, Mauro, additional, Ginès, Pere, additional, Moreau, Richard, additional, Angeli, Paolo, additional, Jalan, Rajiv, additional, Arroyo, Vicente, additional, Maschmeier, Miriam, additional, Semela, David, additional, Elkrief, Laure, additional, Elsharkawy, Ahmed, additional, Tornai, Tamas, additional, Tornai, Istvan, additional, Altorjay, Istvan, additional, Antognoli, Agnese, additional, Baldassarre, Maurizio, additional, Gagliardi, Martina, additional, Bertoli, Eleonora, additional, Mareso, Sara, additional, Brocca, Alessandra, additional, Campion, Daniela, additional, Saracco, Giorgio Maria, additional, Rizzo, Martina, additional, Lehmann, Jennifer, additional, Pohlmann, Alessandra, additional, Brol, Maximilian J., additional, Chang, Johannes, additional, Schierwagen, Robert, additional, Solà, Elsa, additional, Amari, Nesrine, additional, Rodriguez, Miguel, additional, Nevens, Frederik, additional, Clemente, Ana, additional, Janicko, Martin, additional, Markwardt, Daniel, additional, Mandorfer, Mattias, additional, Welsch, Christoph, additional, Welzel, Tanja M., additional, Ciraci, Emanuela, additional, Patel, Vish, additional, Ripoll, Cristina, additional, Herber, Adam, additional, Horn, Paul, additional, Bendtsen, Flemming, additional, Gluud, Lise Lotte, additional, Schaapman, Jelte, additional, Riggio, Oliviero, additional, Rainer, Florian, additional, Moritz, Jörg Tobiasch, additional, Mesquita, Mónica, additional, Alvarado-Tapias, Edilmar, additional, Akpata, Osagie, additional, Aamann, Luise, additional, Samuel, Didier, additional, Tresson, Sylvie, additional, Strnad, Pavel, additional, Amathieu, Roland, additional, Simón-Talero, Macarena, additional, Smits, Francois, additional, van den Ende, Natalie, additional, Martinez, Javier, additional, Garcia, Rita, additional, Rupprechter, Harald, additional, Engelmann, Cornelius, additional, and Özdogan, Osman Cavit, additional

Published
2021
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26. On-treatment serum albumin level can guide long-term treatment in patients with cirrhosis and uncomplicated ascites

Author

Caraceni, Paolo, primary, Tufoni, Manuel, additional, Zaccherini, Giacomo, additional, Riggio, Oliviero, additional, Angeli, Paolo, additional, Alessandria, Carlo, additional, Neri, Sergio, additional, Foschi, Francesco G., additional, Levantesi, Fabio, additional, Airoldi, Aldo, additional, Simone, Loredana, additional, Svegliati-Baroni, Gianluca, additional, Fagiuoli, Stefano, additional, Laffi, Giacomo, additional, Cozzolongo, Raffaele, additional, Di Marco, Vito, additional, Sangiovanni, Vincenzo, additional, Morisco, Filomena, additional, Toniutto, Pierluigi, additional, Gasbarrini, Antonio, additional, De Marco, Rosanna, additional, Piano, Salvatore, additional, Nardelli, Silvia, additional, Elia, Chiara, additional, Roncadori, Andrea, additional, Baldassarre, Maurizio, additional, Bernardi, Mauro, additional, Domenicali, Marco, additional, Giannone, Ferdinando A., additional, Antognoli, Agnese, additional, Merli, Manuela, additional, Pasquale, Chiara, additional, Gioia, Stefania, additional, Fasolato, Silvano, additional, Sticca, Antonietta, additional, Campion, Daniela, additional, Risso, Alessandro, additional, Saracco, Giorgio M., additional, Prestianni, Loredana, additional, Fidone, Federica, additional, Maiorca, Daniela, additional, Rizzotto, Agostino, additional, Cappa, Federica Mirici, additional, Lanzi, Arianna, additional, Neri, Elga, additional, Visani, Anna, additional, Mastroianni, Antonio, additional, Perricone, Giovanni, additional, Alberti, Alberto B., additional, Cesarini, Lucia, additional, Mazzarelli, Chiara, additional, Vangeli, Marcello, additional, Viganò, Raffaella, additional, Marzioni, Marco, additional, Capretti, Francesca, additional, Kostandini, Alba, additional, Magini, Giulia, additional, Colpani, Maria, additional, Gabbani, Tommaso, additional, Marsico, Maria, additional, Zappimbulso, Marianna, additional, Petruzzi, Josè, additional, Calvaruso, Vincenza, additional, Parrella, Giovanni, additional, Caporaso, Nicola, additional, Auriemma, Francesco, additional, Guarino, Maria, additional, Pugliese, Fabio, additional, Tortora, Annalisa, additional, Leo, Pietro, additional, Angelico, Mario, additional, De Leonardis, Francesco, additional, Pecchioli, Alessandra, additional, Rossi, Piera, additional, Raimondo, Giovanni, additional, Cacciola, Irene, additional, Elia, Gianfranco, additional, Negri, Elisa, additional, Dallio, Marcello, additional, Loguercio, Carmelina, additional, Federico, Alessandro, additional, Conte, Dario, additional, Massironi, Sara, additional, Natascia Celli, Giorgio Ballardini, additional, Rendina, Maria, additional, Bringiotti, Roberto, additional, Castellaneta, Nicola Maurizio, additional, Salerno, Francesco, additional, Boccia, Sergio, additional, Guarisco, Riccardo, additional, Galioto, Alessandra, additional, Cavallin, Marta, additional, and Andrealli, Alida, additional

Published
2021
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28. Prognostic Role of Bacterial and Fungal Infections in Patients With Liver Cirrhosis With and Without Acute-on-Chronic Liver Failure: A Prospective 2-Center Study

Author

Bartoletti, Michele, primary, Baldassarre, Maurizio, additional, Domenicali, Marco, additional, Lewis, Russell E, additional, Giannella, Maddalena, additional, Antognoli, Agnese, additional, Rinaldi, Matteo, additional, Zaccherini, Giacomo, additional, Verucchi, Gabriella, additional, Marconi, Lorenzo, additional, Tamè, Mariarosa, additional, Berardi, Sonia, additional, Napoli, Lucia, additional, Siniscalchi, Antonio, additional, Fabbri, Angela, additional, Biselli, Maurizio, additional, Tufoni, Manuel, additional, Pavarin, Raimondo M, additional, Trevisani, Franco, additional, Viale, Pierluigi, additional, Bernardi, Mauro, additional, and Caraceni, Paolo, additional

Published
2020
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29. The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology

Author

Trebicka, Jonel, primary, Fernandez, Javier, additional, Papp, Maria, additional, Caraceni, Paolo, additional, Laleman, Wim, additional, Gambino, Carmine, additional, Giovo, Ilaria, additional, Uschner, Frank Erhard, additional, Jimenez, Cesar, additional, Mookerjee, Rajeshwar, additional, Gustot, Thierry, additional, Albillos, Agustin, additional, Bañares, Rafael, additional, Janicko, Martin, additional, Steib, Christian, additional, Reiberger, Thomas, additional, Acevedo, Juan, additional, Gatti, Pietro, additional, Bernal, William, additional, Zeuzem, Stefan, additional, Zipprich, Alexander, additional, Piano, Salvatore, additional, Berg, Thomas, additional, Bruns, Tony, additional, Bendtsen, Flemming, additional, Coenraad, Minneke, additional, Merli, Manuela, additional, Stauber, Rudolf, additional, Zoller, Heinz, additional, Ramos, José Presa, additional, Solè, Cristina, additional, Soriano, Germán, additional, de Gottardi, Andrea, additional, Gronbaek, Henning, additional, Saliba, Faouzi, additional, Trautwein, Christian, additional, Özdogan, Osman Cavit, additional, Francque, Sven, additional, Ryder, Stephen, additional, Nahon, Pierre, additional, Romero-Gomez, Manuel, additional, Van Vlierberghe, Hans, additional, Francoz, Claire, additional, Manns, Michael, additional, Garcia, Elisabet, additional, Tufoni, Manuel, additional, Amoros, Alex, additional, Pavesi, Marco, additional, Sanchez, Cristina, additional, Curto, Anna, additional, Pitarch, Carla, additional, Putignano, Antonella, additional, Moreno, Esau, additional, Shawcross, Debbie, additional, Aguilar, Ferran, additional, Clària, Joan, additional, Ponzo, Paola, additional, Jansen, Christian, additional, Vitalis, Zsuzsanna, additional, Zaccherini, Giacomo, additional, Balogh, Boglarka, additional, Vargas, Victor, additional, Montagnese, Sara, additional, Alessandria, Carlo, additional, Bernardi, Mauro, additional, Ginès, Pere, additional, Jalan, Rajiv, additional, Moreau, Richard, additional, Angeli, Paolo, additional, Arroyo, Vicente, additional, Maschmeier, Miriam, additional, Semela, David, additional, Elkrief, Laure, additional, Elsharkawy, Ahmed, additional, Tornai, Tamas, additional, Tornai, Istvan, additional, Altorjay, Istvan, additional, Antognoli, Agnese, additional, Baldassarre, Maurizio, additional, Gagliardi, Martina, additional, Bertoli, Eleonora, additional, Mareso, Sara, additional, Brocca, Alessandra, additional, Campion, Daniela, additional, Saracco, Giorgio Maria, additional, Rizzo, Martina, additional, Lehmann, Jennifer, additional, Pohlmann, Alessandra, additional, Praktiknjo, Michael, additional, Schierwagen, Robert, additional, Solà, Elsa, additional, Amari, Nesrine, additional, Rodriguez, Miguel, additional, Nevens, Frederik, additional, Clemente, Ana, additional, Jarcuska, Peter, additional, Gerbes, Alexander, additional, Mandorfer, Mattias, additional, Welsch, Christoph, additional, Ciraci, Emanuela, additional, Patel, Vish, additional, Ripoll, Cristina, additional, Herber, Adam, additional, Horn, Paul, additional, Danielsen, Karen Vagner, additional, Gluud, Lise Lotte, additional, Schaapman, Jelte, additional, Riggio, Oliviero, additional, Rainer, Florian, additional, Moritz, Jörg Tobiasch, additional, Mesquita, Mónica, additional, Alvarado-Tapias, Edilmar, additional, Akpata, Osagie, additional, Lykke Eriksen, Peter, additional, Samuel, Didier, additional, Tresson, Sylvie, additional, Strnad, Pavel, additional, Amathieu, Roland, additional, Simón-Talero, Macarena, additional, Smits, Francois, additional, van den Ende, Natalie, additional, Martinez, Javier, additional, Garcia, Rita, additional, Markwardt, Daniel, additional, Rupprechter, Harald, additional, and Engelmann, Cornelius, additional

Published
2020
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31. Long-term albumin administration is not futile in patients with cirrhosis and uncomplicated ascites not normalizing serum albumin concentration with treatment

Author

Tufoni, Manuel, primary, Caraceni, Paolo, additional, Zaccherini, Giacomo, additional, Riggio, Oliviero, additional, Angeli, Paolo, additional, Alessandria, Carlo, additional, Neri, Sergio, additional, Foschi, Francesco Giuseppe, additional, Levantesi, Fabio, additional, Airoldi, Aldo, additional, Simone, Loredana, additional, Svegiati-Baroni, Gianluca, additional, Fagiuoli, Stefano, additional, Laffi, Giacomo, additional, Cozzolongo, Raffaele, additional, Di Marco, Vito, additional, Sangiovanni, Vincenzo, additional, Morisco, Filomena, additional, Toniutto, Pierluigi, additional, Tortora, Annalisa, additional, De Marco, Rosanna, additional, Nardelli, Silvia, additional, Piano, Salvatore, additional, Elia, Chiara, additional, Roncadori, Andrea, additional, Baldassarre, Maurizio, additional, and Bernardi, Mauro, additional

Published
2020
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33. Effective albumin concentration and albumin function improve after long-term albumin treatment in patients with decompensated cirrhosis

Author

Baldassarre, Maurizio, primary, Tufoni, Manuel, additional, Zaccherini, Giacomo, additional, Campion, Daniela, additional, Foschi, Francesco Giuseppe, additional, Nardelli, Silvia, additional, Morisco, Filomena, additional, Federico, Alessandro, additional, Massironi, Sara, additional, Airoldi, Aldo, additional, Vizzutti, Francesco, additional, Antognoli, Agnese, additional, Gagliardi, Martina, additional, Donadei, Chiara, additional, Waterstradt, Katja, additional, Naldi, Marina, additional, Bernardi, Mauro, additional, and Caraceni, Paolo, additional

Published
2020
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34. Subtle changes of serum creatinine and C-reactive protein during the index hospitalization predict early readmission in patients with decompensated cirrhosis

Author

Tufoni, Manuel, primary, Zaccherini, Giacomo, additional, Bartoletti, Michele, additional, Baldassarre, Maurizio, additional, Antognoli, Agnese, additional, Leoni, Simona, additional, Berardi, Sonia, additional, Tamé, Mariarosa, additional, Marconi, Lorenzo, additional, Basigli, Elisa, additional, Iannone, Giulia, additional, Pratelli, Dario, additional, Domenicali, Marco, additional, Viale, Pierluigi, additional, Trevisani, Franco, additional, and Caraceni, Paolo, additional

Published
2020
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36. The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology

Author

Trebicka, Jonel, Fernandez, Javier, Papp, Maria, Caraceni, Paolo, Laleman, Wim, Gambino, Carmine, Giovo, Ilaria, Uschner, Frank Erhard, Jimenez, Cesar, Mookerjee, Rajeshwar, Gustot, Thierry, Albillos, Agustin, Bañares, Rafael, Janicko, Martin, Steib, Christian, Reiberger, Thomas, Acevedo, Juan, Gatti, Pietro, Bernal, William, Zeuzem, Stefan, Zipprich, Alexander, Piano, Salvatore, Berg, Thomas, Bruns, Tony, Bendtsen, Flemming, Coenraad, Minneke, Merli, Manuela, Stauber, Rudolf, Zoller, Heinz, Ramos, José Presa, Solè, Cristina, Soriano, Germán, de Gottardi, Andrea, Gronbaek, Henning, Saliba, Faouzi, Trautwein, Christian, Özdogan, Osman Cavit, Francque, Sven, Ryder, Stephen, Nahon, Pierre, Romero-Gomez, Manuel, Van Vlierberghe, Hans, Francoz, Claire, Manns, Michael, Garcia, Elisabet, Tufoni, Manuel, Amoros, Alex, Pavesi, Marco, Danielsen, Karen Vagner, Gluud, Lise Lotte, Trebicka, Jonel, Fernandez, Javier, Papp, Maria, Caraceni, Paolo, Laleman, Wim, Gambino, Carmine, Giovo, Ilaria, Uschner, Frank Erhard, Jimenez, Cesar, Mookerjee, Rajeshwar, Gustot, Thierry, Albillos, Agustin, Bañares, Rafael, Janicko, Martin, Steib, Christian, Reiberger, Thomas, Acevedo, Juan, Gatti, Pietro, Bernal, William, Zeuzem, Stefan, Zipprich, Alexander, Piano, Salvatore, Berg, Thomas, Bruns, Tony, Bendtsen, Flemming, Coenraad, Minneke, Merli, Manuela, Stauber, Rudolf, Zoller, Heinz, Ramos, José Presa, Solè, Cristina, Soriano, Germán, de Gottardi, Andrea, Gronbaek, Henning, Saliba, Faouzi, Trautwein, Christian, Özdogan, Osman Cavit, Francque, Sven, Ryder, Stephen, Nahon, Pierre, Romero-Gomez, Manuel, Van Vlierberghe, Hans, Francoz, Claire, Manns, Michael, Garcia, Elisabet, Tufoni, Manuel, Amoros, Alex, Pavesi, Marco, Danielsen, Karen Vagner, and Gluud, Lise Lotte

Abstract

Background & Aims: Acute decompensation (AD) of cirrhosis is defined as the acute development of ascites, gastrointestinal hemorrhage, hepatic encephalopathy, infection or any combination thereof, requiring hospitalization. The presence of organ failure(s) in patients with AD defines acute-on-chronic liver failure (ACLF). The PREDICT study is a European, prospective, observational study, designed to characterize the clinical course of AD and to identify predictors of ACLF. Methods: A total of 1,071 patients with AD were enrolled. We collected detailed pre-specified information on the 3-month period prior to enrollment, and clinical and laboratory data at enrollment. Patients were then closely followed up for 3 months. Outcomes (liver transplantation and death) at 1 year were also recorded. Results: Three groups of patients were identified. Pre-ACLF patients (n = 218) developed ACLF and had 3-month and 1-year mortality rates of 53.7% and 67.4%, respectively. Unstable decompensated cirrhosis (UDC) patients (n = 233) required ≥1 readmission but did not develop ACLF and had mortality rates of 21.0% and 35.6%, respectively. Stable decompensated cirrhosis (SDC) patients (n = 620) were not readmitted, did not develop ACLF and had a 1-year mortality rate of only 9.5%. The 3 groups differed significantly regarding the grade and course of systemic inflammation (high-grade at enrollment with aggravation during follow-up in pre-ACLF; low-grade at enrollment with subsequent steady-course in UDC; and low-grade at enrollment with subsequent improvement in SDC) and the prevalence of surrogates of severe portal hypertension throughout the study (high in UDC vs. low in pre-ACLF and SDC). Conclusions: Acute decompensation without ACLF is a heterogeneous condition with 3 different clinical courses and 2 major pathophysiological mechanisms: systemic inflammation and portal hypertension. Predicting the development of ACLF remains a major future challenge. ClinicalTrials.gov number

Published
2020

37. PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis.

Author

Trebicka, Jonel, Fernandez, Javier, Papp, Maria, Caraceni, Paolo, Laleman, Wim, Gambino, Carmine, Giovo, Ilaria, Uschner, Frank Erhard, Jansen, Christian, Jimenez, Cesar, Mookerjee, Rajeshwar, Gustot, Thierry, Albillos, Agustin, Bañares, Rafael, Jarcuska, Peter, Steib, Christian, Reiberger, Thomas, Acevedo, Juan, Gatti, Pietro, Shawcross, Debbie, Zeuzem, Stefan, Zipprich, Alexander, Piano, Salvatore, Berg, Thomas, Bruns, Tony, Danielsen, Karen Vagner, Coenraad, Minneke, Merli, Manuela, Stauber, Rudolf, Zoller, Heinz, Ramos, José Presa, Solè, Cristina, Soriano, German, de Gottardi, Andrea, Gronbaek, Henning, Saliba, Faouzi, Trautwein, Christian, Kani, Haluk Tarik, Francque, Sven, Ryder, Stephen, Nahon, Pierre, Romero-Gomez, Manuel, Van Vlierberghe, Hans, Francoz, Claire, Manns, Michael, Garcia-Lopez, Elisabet, Tufoni, Manuel, Amoros, Alex, Pavesi, Marco, Sanchez, Cristina, Praktiknjo, Michael, Curto, Anna, Pitarch, Carla, Putignano, Antonella, Moreno, Esau, Bernal, William, Aguilar, Ferrán, Clària, Joan, Ponzo, Paola, Vitalis, Zsuzsanna, Zaccherini, Giacomo, Balogh, Boglarka, Gerbes, Alexander L., Vargas, Victor, Alessandria, Carlo, Bernardi, Mauro, Gines, Pere, Moreau, Richard, Angeli, Paolo, Jalan, Rajiv, Arroyo, Vicente, PREDICT STUDY group of the EASL-CLIF CONSORTIUM, Trebicka, Jonel, Fernandez, Javier, Papp, Maria, Caraceni, Paolo, Laleman, Wim, Gambino, Carmine, Giovo, Ilaria, Uschner, Frank Erhard, Jansen, Christian, Jimenez, Cesar, Mookerjee, Rajeshwar, Gustot, Thierry, Albillos, Agustin, Bañares, Rafael, Jarcuska, Peter, Steib, Christian, Reiberger, Thomas, Acevedo, Juan, Gatti, Pietro, Shawcross, Debbie, Zeuzem, Stefan, Zipprich, Alexander, Piano, Salvatore, Berg, Thomas, Bruns, Tony, Danielsen, Karen Vagner, Coenraad, Minneke, Merli, Manuela, Stauber, Rudolf, Zoller, Heinz, Ramos, José Presa, Solè, Cristina, Soriano, German, de Gottardi, Andrea, Gronbaek, Henning, Saliba, Faouzi, Trautwein, Christian, Kani, Haluk Tarik, Francque, Sven, Ryder, Stephen, Nahon, Pierre, Romero-Gomez, Manuel, Van Vlierberghe, Hans, Francoz, Claire, Manns, Michael, Garcia-Lopez, Elisabet, Tufoni, Manuel, Amoros, Alex, Pavesi, Marco, Sanchez, Cristina, Praktiknjo, Michael, Curto, Anna, Pitarch, Carla, Putignano, Antonella, Moreno, Esau, Bernal, William, Aguilar, Ferrán, Clària, Joan, Ponzo, Paola, Vitalis, Zsuzsanna, Zaccherini, Giacomo, Balogh, Boglarka, Gerbes, Alexander L., Vargas, Victor, Alessandria, Carlo, Bernardi, Mauro, Gines, Pere, Moreau, Richard, Angeli, Paolo, Jalan, Rajiv, Arroyo, Vicente, and PREDICT STUDY group of the EASL-CLIF CONSORTIUM

Abstract

Acute decompensation (AD) of cirrhosis may present without acute-on-chronic liver failure (ACLF) (AD-No ACLF), or with ACLF phenotype (AD-ACLF) defined by organ failure(s). Precipitants may induce AD. This multicenter, prospective, observational PREDICT study (NCT03056612) analyzes and characterizes the precipitants leading to both of these AD phenotypes., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2020

38. On-treatment serum albumin level can guide long-term treatment in patients with cirrhosis and uncomplicated ascites

Author

Caraceni, Paolo, Tufoni, Manuel, Zaccherini, Giacomo, Riggio, Oliviero, Angeli, Paolo, Alessandria, Carlo, Neri, Sergio, Foschi, Francesco G, Levantesi, Fabio, Airoldi, Aldo, Simone, Loredana, Svegliati-Baroni, Gianluca, Fagiuoli, Stefano, Laffi, Giacomo, Cozzolongo, Raffaele, Di Marco, Vito, Sangiovanni, Vincenzo, Morisco, Filomena, Toniutto, Pierluigi, Gasbarrini, Antonio, De Marco, Rosanna, Piano, Salvatore, Nardelli, Silvia, Elia, Chiara, Roncadori, Andrea, Baldassarre, Maurizio, Bernardi, Mauro, Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Caraceni, Paolo, Tufoni, Manuel, Zaccherini, Giacomo, Riggio, Oliviero, Angeli, Paolo, Alessandria, Carlo, Neri, Sergio, Foschi, Francesco G, Levantesi, Fabio, Airoldi, Aldo, Simone, Loredana, Svegliati-Baroni, Gianluca, Fagiuoli, Stefano, Laffi, Giacomo, Cozzolongo, Raffaele, Di Marco, Vito, Sangiovanni, Vincenzo, Morisco, Filomena, Toniutto, Pierluigi, Gasbarrini, Antonio, De Marco, Rosanna, Piano, Salvatore, Nardelli, Silvia, Elia, Chiara, Roncadori, Andrea, Baldassarre, Maurizio, Bernardi, Mauro, and Gasbarrini, Antonio (ORCID:0000-0002-7278-4823)

Abstract

N/A

Published
2020

39. Long-term albumin administration in decompensated cirrhosis (ANSWER): an open-label randomised trial

Author

Caraceni, Paolo, Riggio, Oliviero, Angeli, Paolo, Alessandria, Carlo, Neri, Sergio, Foschi, Francesco G, Levantesi, Fabio, Airoldi, Aldo, Boccia, Sergio, Svegliati-Baroni, Gianluca, Fagiuoli, Stefano, Romanelli, Roberto G, Cozzolongo, Raffaele, Di Marco, Vito, Sangiovanni, Vincenzo, Morisco, Filomena, Toniutto, Pierluigi, Tortora, Annalisa, De Marco, Rosanna, Angelico, Mario, Cacciola, Irene, Elia, Gianfranco, Federico, Alessandro, Massironi, Sara, Guarisco, Riccardo, Galioto, Alessandra, Ballardini, Giorgio, Rendina, Maria, Nardelli, Silvia, Piano, Salvatore, Elia, Chiara, Prestianni, Loredana, Cappa, Federica Mirici, Cesarini, Lucia, Simone, Loredana, Pasquale, Chiara, Cavallin, Marta, Andrealli, Alida, Fidone, Federica, Ruggeri, Matteo, Roncadori, Andrea, Baldassarre, Maurizio, Tufoni, Manuel, Zaccherini, Giacomo, Bernardi, Mauro, Domenicali, Marco, Giannone, Ferdinando A, Merli, Manuela, Gioia, Stefania, Fasolato, Silvano, Sticca, Antonietta, Campion, Daniela, Risso, Alessandro, Saracco, Giorgio M, Maiorca, Daniela, Rizzotto, Agostino, Lanzi, Arianna, Neri, Elga, Visani, Anna, Mastroianni, Antonio, Alberti, Alberto B, Mazzarelli, Chiara, Vangeli, Marcello, Marzioni, Marco, Capretti, Francesca, Kostandini, Alba, Magini, Giulia, Colpani, Maria, Laffi, Giacomo, Gabbani, Tommaso, Marsico, Maria, Zappimbulso, Marianna, Petruzzi, Josè, Calvaruso, Vincenza, Parrella, Giovanni, Caporaso, Nicola, Auriemma, Francesco, Guarino, Maria, Pugliese, Fabio, Gasbarrini, Antonio, Leo, Pietro, De Leonardis, Francesco, Pecchioli, Alessandra, Rossi, Piera, Raimondo, Giovanni, Negri, Elisa, Dallio, Marcello, Loguercio, Carmelina, Conte, Dario, Celli, Natascia, Bringiotti, Roberto, Castellaneta, Nicola M, Salerno, Francesco, ANSWER Study Investigators, Caraceni, Paolo, Riggio, Oliviero, Angeli, Paolo, Alessandria, Carlo, Neri, Sergio, Foschi, Francesco G, Levantesi, Fabio, Airoldi, Aldo, Boccia, Sergio, Svegliati-Baroni, Gianluca, Fagiuoli, Stefano, Romanelli, Roberto G, Cozzolongo, Raffaele, Di Marco, Vito, Sangiovanni, Vincenzo, Morisco, Filomena, Toniutto, Pierluigi, Tortora, Annalisa, De Marco, Rosanna, Angelico, Mario, Cacciola, Irene, Elia, Gianfranco, Federico, Alessandro, Massironi, Sara, Guarisco, Riccardo, Galioto, Alessandra, Ballardini, Giorgio, Rendina, Maria, Nardelli, Silvia, Piano, Salvatore, Elia, Chiara, Prestianni, Loredana, Cappa, Federica Mirici, Cesarini, Lucia, Simone, Loredana, Pasquale, Chiara, Cavallin, Marta, Andrealli, Alida, Fidone, Federica, Ruggeri, Matteo, Roncadori, Andrea, Baldassarre, Maurizio, Tufoni, Manuel, Zaccherini, Giacomo, Bernardi, Mauro, Domenicali, Marco, Giannone, Ferdinando A, Merli, Manuela, Gioia, Stefania, Fasolato, Silvano, Sticca, Antonietta, Campion, Daniela, Risso, Alessandro, Saracco, Giorgio M, Maiorca, Daniela, Rizzotto, Agostino, Lanzi, Arianna, Neri, Elga, Visani, Anna, Mastroianni, Antonio, Alberti, Alberto B, Mazzarelli, Chiara, Vangeli, Marcello, Marzioni, Marco, Capretti, Francesca, Kostandini, Alba, Magini, Giulia, Colpani, Maria, Laffi, Giacomo, Gabbani, Tommaso, Marsico, Maria, Zappimbulso, Marianna, Petruzzi, Josè, Calvaruso, Vincenza, Parrella, Giovanni, Caporaso, Nicola, Auriemma, Francesco, Guarino, Maria, Pugliese, Fabio, Gasbarrini, Antonio, Leo, Pietro, De Leonardis, Francesco, Pecchioli, Alessandra, Rossi, Piera, Raimondo, Giovanni, Negri, Elisa, Dallio, Marcello, Loguercio, Carmelina, Conte, Dario, Celli, Natascia, Bringiotti, Roberto, Castellaneta, Nicola M, Salerno, Francesco, Caraceni P1, Riggio O2, Angeli P3, Alessandria C4, Neri S5, Foschi FG6, Levantesi F7, Airoldi A8, Boccia S9, Svegliati-Baroni G10, Fagiuoli S11, Romanelli RG12, Cozzolongo R13, Di Marco Vito, Sangiovanni V15, Morisco F16, Toniutto P17, Tortora A18, De Marco R19, Angelico M20, Cacciola I21, Elia G22, Federico A23, Massironi S24, Guarisco R25, Galioto A26, Ballardini G27, Rendina M28, Nardelli S2, Piano S3, Elia C4, Prestianni L5, Cappa FM6, Cesarini L8, Simone L9, Pasquale C2, Cavallin M3, Andrealli A4, Fidone F5, Ruggeri M29, Roncadori A30, Baldassarre M1, Tufoni M1, Zaccherini G1, Bernardi M31, Domenicali M, Giannone FA, Merli M, Gioia S, Fasolato S, Sticca A, Campion D, Risso A, Saracco GM, Maiorca D, Rizzotto A, Lanzi A, Neri E, Visani A, Mastroianni A, Alberti AB, Mazzarelli C, Vangeli M, Marzioni M, Capretti F, Kostandini A, Magini G, Colpani M, Laffi G, Gabbani T, Marsico M, Zappimbulso M, Petruzzi J, Calvaruso Vincenza, Parrella G, Caporaso N, Auriemma F, Guarino M, Pugliese F, Gasbarrini A, Leo P, De Leonardis F, Pecchioli A, Rossi P, Raimondo G, Negri E, Dallio M, Loguercio C, Conte D, Celli N, Bringiotti R, Castellaneta NM, Salerno F., Caraceni P, Riggio O, Angeli P, Alessandria C, Neri S, Foschi FG, Levantesi F, Airoldi A, Boccia S, Svegliati-Baroni G, Fagiuoli S, Romanelli RG, Cozzolongo R, Di Marco V, Sangiovanni V, Morisco F, Toniutto P, Tortora A, De Marco R, Angelico M, Cacciola I, Elia G, Federico A, Massironi S, Guarisco R, Galioto A, Ballardini G, Rendina M, Nardelli S, Piano S, Elia C, Prestianni L, Cappa FM, Cesarini L, Simone L, Pasquale C, Cavallin M, Andrealli A, Fidone F, Ruggeri M, Roncadori A, Baldassarre M, Tufoni M, Zaccherini G, Bernardi M, Domenicali M, Giannone FA, Merli M, Gioia S, Fasolato S, Sticca A, Campion D, Risso A, Saracco GM, Maiorca D, Rizzotto A, Lanzi A, Neri E, Visani A, Mastroianni A, Alberti AB, Mazzarelli C, Vangeli M, Marzioni M, Capretti F, Kostandini A, Magini G, Colpani M, Laffi G, Gabbani T, Marsico M, Zappimbulso M, Petruzzi J, Calvaruso V, Parrella G, Caporaso N, Auriemma F, Guarino M, Pugliese F, Gasbarrini A, Leo P, De Leonardis F, Pecchioli A, Rossi P, Raimondo G, Negri E, Dallio M, Loguercio C, Conte D, Celli N, Bringiotti R, Castellaneta NM, Salerno F., Caraceni, P, Riggio, O, Angeli, P, Alessandria, C, Neri, S, Foschi, F, Levantesi, F, Airoldi, A, Boccia, S, Svegliati-Baroni, G, Fagiuoli, S, Romanelli, R, Cozzolongo, R, Di Marco, V, Sangiovanni, V, Morisco, F, Toniutto, P, Tortora, A, De Marco, R, Angelico, M, Cacciola, I, Elia, G, Federico, A, Massironi, S, Guarisco, R, Galioto, A, Ballardini, G, Rendina, M, Nardelli, S, Piano, S, Elia, C, Prestianni, L, Cappa, F, Cesarini, L, Simone, L, Pasquale, C, Cavallin, M, Andrealli, A, Fidone, F, Ruggeri, M, Roncadori, A, Baldassarre, M, Tufoni, M, Zaccherini, G, Bernardi, M, Domenicali, M, Giannone, F, Merli, M, Gioia, S, Fasolato, S, Sticca, A, Campion, D, Risso, A, Saracco, G, Maiorca, D, Rizzotto, A, Lanzi, A, Neri, E, Visani, A, Mastroianni, A, Alberti, A, Mazzarelli, C, Vangeli, M, Marzioni, M, Capretti, F, Kostandini, A, Magini, G, Colpani, M, Laffi, G, Gabbani, T, Marsico, M, Zappimbulso, M, Petruzzi, J, Calvaruso, V, Parrella, G, Caporaso, N, Auriemma, F, Guarino, M, Pugliese, F, Gasbarrini, A, Leo, P, De Leonardis, F, Pecchioli, A, Rossi, P, Raimondo, G, Negri, E, Dallio, M, Loguercio, C, Conte, D, Celli, N, Bringiotti, R, Castellaneta, N, and Salerno, F

Subjects
Liver Cirrhosis, Male, Time Factors, Cirrhosis, Kaplan-Meier Estimate, law.invention, ascites, 0302 clinical medicine, Hepatorenal syndrome, Randomized controlled trial, Furosemide, law, Ascites, Clinical endpoint, Paracentesis, Diuretics, albumin, decompensated cirrhosi, Mineralocorticoid Receptor Antagonists, Settore MED/12 - Gastroenterologia, Medicine (all), Hazard ratio, General Medicine, Middle Aged, Survival Rate, 030220 oncology & carcinogenesis, Drug Therapy, Combination, Female, 030211 gastroenterology & hepatology, Quality-Adjusted Life Years, medicine.symptom, Hyponatremia, medicine.medical_specialty, 03 medical and health sciences, Albumins, Internal medicine, medicine, Humans, Survival rate, albumin, Aged, business.industry, cirrhosis, medicine.disease, Clinical trial, albumin, cirrhosis, ascites, liver decompensation, Quality of Life, Hyperkalemia, business, Esophagus Varices, Portal Hypertension, Varicosis
Abstract

Background Evidence is scarce on the efficacy of long-term human albumin (HA) administration in patients with decompensated cirrhosis. The human Albumin for the treatmeNt of aScites in patients With hEpatic ciRrhosis (ANSWER) study was designed to clarify this issue. Methods We did an investigator-initiated multicentre randomised, parallel, open-label, pragmatic trial in 33 academic and non-academic Italian hospitals. We randomly assigned patients with cirrhosis and uncomplicated ascites who were treated with anti-aldosteronic drugs (≥200 mg/day) and furosemide (≥25 mg/day) to receive either standard medical treatment (SMT) or SMT plus HA (40 g twice weekly for 2 weeks, and then 40 g weekly) for up to 18 months. The primary endpoint was 18-month mortality, evaluated as difference of events and analysis of survival time in patients included in the modified intention-to-treat and per-protocol populations. This study is registered with EudraCT, number 2008–000625–19, and ClinicalTrials.gov, number NCT01288794. Findings From April 2, 2011, to May 27, 2015, 440 patients were randomly assigned and 431 were included in the modified intention-to-treat analysis. 38 of 218 patients died in the SMT plus HA group and 46 of 213 in the SMT group. Overall 18-month survival was significantly higher in the SMT plus HA than in the SMT group (Kaplan-Meier estimates 77% vs 66%; p=0·028), resulting in a 38% reduction in the mortality hazard ratio (0·62 [95% CI 0·40–0·95]). 46 (22%) patients in the SMT group and 49 (22%) in the SMT plus HA group had grade 3–4 non-liver related adverse events. Interpretation In this trial, long-term HA administration prolongs overall survival and might act as a disease modifying treatment in patients with decompensated cirrhosis. Funding Italian Medicine Agency. Copyright © 2018 Elsevier Ltd. All rights reserved.

Published
2018

43. PS-083-Serum albumin concentration as guide for long-term albumin treatment in patients with cirrhosis and uncomplicated ascites: Lessons from the ANSWER study

Author

Caraceni, Paolo, primary, Riggio, Oliviero, additional, Angeli, Paolo, additional, Alessandria, Carlo, additional, Neri, Sergio, additional, Foschi, Francesco Giuseppe, additional, Levantesi, Fabio, additional, Airoldi, Aldo, additional, Simone, Loredana, additional, Svegiati-Baroni, Gianluca, additional, Fagiuoli, Stefano, additional, Romanelli, Roberto Giulio, additional, Cozzolongo, Raffaele, additional, Marco, Vito Di, additional, Sangiovanni, Vincenzo, additional, Morisco, Filomena, additional, Toniutto, Pierluigi, additional, Tortora, Annalisa, additional, Marco, Rosanna De, additional, Nardelli, Silvia, additional, Piano, Salvatore, additional, Elia, Chiara, additional, Roncadori, Andrea, additional, Tufoni, Manuel, additional, Zaccherini, Giacomo, additional, and Bernardi, Mauro, additional

Published
2019
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44. Clinical Role of Lung Ultrasound for the Diagnosis and Prognosis of Coronavirus Disease Pneumonia in Elderly Patients: A Pivotal Study.

Author

Recinella, Guerino, Marasco, Giovanni, Tufoni, Manuel, Brizi, Mara, Evangelisti, Eleonora, Maestri, Lorenzo, Fusconi, Marco, Calogero, Pietro, Magalotti, Donatella, and Zoli, Marco

Subjects
COVID-19, PROGNOSIS, OLDER patients, SARS-CoV-2, LUNGS, DIAGNOSIS, HOSPITAL beds
Abstract

Background: Lung ultrasound (LUS) showed a promising role in the diagnosis and monitoring of patients hospitalized for novel coronavirus disease (COVID-19). However, no data are available on its role in elderly patients. Aims: The aim of this study was to evaluate the diagnostic and prognostic role of LUS in elderly patients hospitalized for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pneumonia. Methods: Consecutive elderly patients (age >65 years) hospitalized for COVID-19 were enrolled. Demographics, laboratory, comorbidity, and the clinical features of the patients were collected. All patients underwent LUS on admission to the ward. LUS characteristics have been analyzed. Uni- and multivariate analyses to evaluate predictors for in-hospital death were performed. Results: Thirty-seven hospitalized elderly patients (19 men) with a diagnosis of SARS-CoV-2 infection were consecutively enrolled. The median age was 82 years (interquartile range 74.5–93.5). Ultrasound alterations were found in all patients enrolled; inhomogeneous interstitial syndrome with spared areas (91.9%) and pleural alterations (100%) were the most frequent findings. At univariate analysis, LUS score (hazard ratio [HR] 1.168, 95% CI 1.049–1.301) and pleural effusions (HR 3.995, 95% CI 1.056–15.110) were associated with in-hospital death. At multivariate analysis, only LUS score (HR 1.168, 95% CI 1.049–1.301) was independelty associated with in-hospital death. The LUS score's best cutoff for distinguishing patients experiencing in-hospital death was 17 (at multivariate analysis LUS score ≥17, HR 4.827, 95% CI 1.452–16.040). In-hospital death was significantly different according to the LUS score cutoff of 17 (p = 0.0046). Conclusion: LUS could play a role in the diagnosis and prognosis in elderly patients hospitalized for SARS-CoV-2 infection. [ABSTRACT FROM AUTHOR]

Published
2021
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46. Long-term albumin administration in decompensated cirrhosis (ANSWER): an open-label randomised trial

Author

Caraceni, Paolo, primary, Riggio, Oliviero, additional, Angeli, Paolo, additional, Alessandria, Carlo, additional, Neri, Sergio, additional, Foschi, Francesco G, additional, Levantesi, Fabio, additional, Airoldi, Aldo, additional, Boccia, Sergio, additional, Svegliati-Baroni, Gianluca, additional, Fagiuoli, Stefano, additional, Romanelli, Roberto G, additional, Cozzolongo, Raffaele, additional, Di Marco, Vito, additional, Sangiovanni, Vincenzo, additional, Morisco, Filomena, additional, Toniutto, Pierluigi, additional, Tortora, Annalisa, additional, De Marco, Rosanna, additional, Angelico, Mario, additional, Cacciola, Irene, additional, Elia, Gianfranco, additional, Federico, Alessandro, additional, Massironi, Sara, additional, Guarisco, Riccardo, additional, Galioto, Alessandra, additional, Ballardini, Giorgio, additional, Rendina, Maria, additional, Nardelli, Silvia, additional, Piano, Salvatore, additional, Elia, Chiara, additional, Prestianni, Loredana, additional, Cappa, Federica Mirici, additional, Cesarini, Lucia, additional, Simone, Loredana, additional, Pasquale, Chiara, additional, Cavallin, Marta, additional, Andrealli, Alida, additional, Fidone, Federica, additional, Ruggeri, Matteo, additional, Roncadori, Andrea, additional, Baldassarre, Maurizio, additional, Tufoni, Manuel, additional, Zaccherini, Giacomo, additional, Bernardi, Mauro, additional, Domenicali, Marco, additional, Giannone, Ferdinando A, additional, Merli, Manuela, additional, Gioia, Stefania, additional, Fasolato, Silvano, additional, Sticca, Antonietta, additional, Campion, Daniela, additional, Risso, Alessandro, additional, Saracco, Giorgio M, additional, Maiorca, Daniela, additional, Rizzotto, Agostino, additional, Lanzi, Arianna, additional, Neri, Elga, additional, Visani, Anna, additional, Mastroianni, Antonio, additional, Alberti, Alberto B, additional, Mazzarelli, Chiara, additional, Vangeli, Marcello, additional, Marzioni, Marco, additional, Capretti, Francesca, additional, Kostandini, Alba, additional, Magini, Giulia, additional, Colpani, Maria, additional, Laffi, Giacomo, additional, Gabbani, Tommaso, additional, Marsico, Maria, additional, Zappimbulso, Marianna, additional, Petruzzi, Josè, additional, Calvaruso, Vincenza, additional, Parrella, Giovanni, additional, Caporaso, Nicola, additional, Auriemma, Francesco, additional, Guarino, Maria, additional, Pugliese, Fabio, additional, Gasbarrini, Antonio, additional, Leo, Pietro, additional, De Leonardis, Francesco, additional, Pecchioli, Alessandra, additional, Rossi, Piera, additional, Raimondo, Giovanni, additional, Negri, Elisa, additional, Dallio, Marcello, additional, Loguercio, Carmelina, additional, Conte, Dario, additional, Celli, Natascia, additional, Bringiotti, Roberto, additional, Castellaneta, Nicola M, additional, and Salerno, Francesco, additional

Published
2018
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47. THU145 - Effective albumin concentration and albumin function improve after long-term albumin treatment in patients with decompensated cirrhosis

Author

Baldassarre, Maurizio, Tufoni, Manuel, Zaccherini, Giacomo, Campion, Daniela, Foschi, Francesco Giuseppe, Nardelli, Silvia, Morisco, Filomena, Federico, Alessandro, Massironi, Sara, Airoldi, Aldo, Vizzutti, Francesco, Antognoli, Agnese, Gagliardi, Martina, Donadei, Chiara, Waterstradt, Katja, Naldi, Marina, Bernardi, Mauro, and Caraceni, Paolo

Published
2020
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49. Acute Liver Failure Caused by Amanita phalloides Poisoning

Author

Santi, Luca, Maggioli, Caterina, Mastroroberto, Marianna, Tufoni, Manuel, Napoli, Lucia, and Caraceni, Paolo

Subjects
Article Subject
Abstract

Mushroom poisoning is a relatively rare cause of acute liver failure (ALF). The present paper analyzes the pathogenesis, clinical features, prognostic indicators, and therapeutic strategies of ALF secondary to ingestion of Amanita phalloides, which represents the most common and deadly cause of mushroom poisoning. Liver damage from Amanita phalloides is related to the amanitins, powerful toxins that inhibit RNA polymerase II resulting in a deficient protein synthesis and cell necrosis. After an asymptomatic lag phase, the clinical picture is characterized by gastrointestinal symptoms, followed by the liver and kidney involvement. Amatoxin poisoning may progress into ALF and eventually death if liver transplantation is not performed. The mortality rate after Amanita phalloides poisoning ranges from 10 to 20%. The management of amatoxin poisoning consists of preliminary medical care, supportive measures, detoxification therapies, and orthotopic liver transplantation. The clinical efficacy of any modality of treatment is difficult to demonstrate since randomized, controlled clinical trials have not been reported. The use of extracorporeal liver assist devices as well as auxiliary liver transplantation may represent additional therapeutic options.

Published
2012
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