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Your search keyword '"Tuo, Shaoyong"' showing total 3 results
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3 results on '"Tuo, Shaoyong"'

1. Correlation between angiopoietin-like proteins in inflammatory mediators in peripheral blood and severity of coronary arterial lesion in patients with acute myocardial infarction

Author

Li Rongqing, Zhang Fengping, Tuo Shaoyong, Guo Zhaozeng, Cao Yuejuan, and Yuming Li

Subjects
0301 basic medicine, Cancer Research, medicine.medical_specialty, acute myocardial infarction, Disease, 03 medical and health sciences, 0302 clinical medicine, Immunology and Microbiology (miscellaneous), Internal medicine, medicine, Myocardial infarction, Interleukin 6, Coronary atherosclerosis, IL-6, biology, Oncogene, business.industry, Angptl 2, Cancer, Articles, General Medicine, medicine.disease, Molecular medicine, Stenosis, 030104 developmental biology, 030220 oncology & carcinogenesis, biology.protein, Cardiology, coronary arterial lesion, business
Abstract

The effects of angiopoietin-like protein 2 (Angptl 2) and interleukin-6 (IL-6) in inflammatory mediators on the severity of coronary arterial lesion in patients with acute myocardial infarction were investigated. One hundred and twenty-six patients with acute myocardial infarction admitted to Tianjin Union Medical Center (the myocardial infarction group) and 133 healthy individuals (the control group) were selected for retrospective analysis from January 2013 to December 2015. The levels of Angptl 2 and IL-6 in serum of patients were detected by enzyme linked immunosorbent assay (ELISA), and the correlation analysis between the levels and the degree of coronary stenosis in patients with myocardial infarction was conducted. The expression level of Angptl 2 and IL-6 in the myocardial infarction group was significantly higher than that in the control group P

Published
2019

3. Resveratrol mediates mitochondrial function through the sirtuin 3 pathway to improve abnormal metabolic remodeling in atrial fibrillation.

Author

Cao Y, Cui L, Tuo S, Liu H, and Cui S

Subjects
Animals, Mice, Cell Line, Signal Transduction drug effects, Membrane Potential, Mitochondrial drug effects, Mitochondria metabolism, Mitochondria drug effects, Mitochondria, Heart metabolism, Mitochondria, Heart drug effects, Reactive Oxygen Species metabolism, Resveratrol pharmacology, Sirtuin 3 metabolism, Atrial Fibrillation metabolism, Atrial Fibrillation drug therapy
Abstract

This study investigated the impact of resveratrol on abnormal metabolic remodeling in atrial fibrillation (AF) and explored potential molecular mechanisms. An AF cell model was established by high-frequency electrical stimulation of HL-1 atrial muscle cells. Resveratrol concentrations were optimized using CCK-8 and flow cytometry. AF-induced increases in ROS and mitochondrial calcium, along with decreased adenosine triphosphate (ATP) and mitochondrial membrane potential, were observed. Resveratrol mitigated these changes and maintained normal mitochondrial morphology. Moreover, resveratrol acted through the SIRT3-dependent pathway, as evidenced by its ability to suppress AF-induced acetylation of key metabolic enzymes. SIRT3 overexpression controls acetylation modifications, suggesting its regulatory role. In conclusion, resveratrol's SIRT3-dependent pathway intervenes in AF-induced mitochondrial dysfunction, presenting a potential therapeutic avenue for AF-related metabolic disorders. This study sheds light on the role of resveratrol in mitigating AF-induced mitochondrial remodeling and highlights its potential as a novel treatment for AF.

Published
2024
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