26 results on '"Turkkan, E"'
Search Results
2. PHARMACOKINETIC-GUIDED PROPHYLAXIS BASED ON BAYESIAN MODEL WITH MYPKFIT (R) IN HEMOPHILIA A: TURKISH EXPERIENCE
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Zulfikar, B., Albayrak, D., Sasmaz, I., Celkan, T., Ozbek, N. Y., Turkkan, E., Canbolat, A., Karaman, S., Yagci, M., Evim, M., Ozdemir, G. N., Aytac, S., Koc, B., Albayrak, C., Balkan, C., Gulen, H., Ay, Y., Okan, V., Aksu, S., Ileri, T., Andic, N., Oymak, Y., Patiroglu, T., Sahin, F., Erduran, E., Kavakli, K., Kaya, Z., Yilmaz, B., Antmen, B., Soker, M., Zengin, E., Kupesiz, A., Oren, H., and Umit, E.
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- 2020
3. Multidisciplinary team for treatment of hemophilia, Istanbul experience: PO-TU-003
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TIMUR, C., AYDOGAN, G., ALTUN, M., SALCiOGLU, Z., TURKKAN, E., SEN, H., OZULKER, T., AKCAY, A., AYHAN, CANBOLAT A., BASOGLU, F., ATAY, D., and AKiCi, F.
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- 2012
4. Pharmacokinetic-guided prophylaxis based on bayesian model with myPKFiT (R) in hemophilia A: Turkish experience
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Balkan, C., Albayrak, C., Ozbek, N. Y., Kaya, Z., Sasmaz, I., Celkan, T., Yagci, M., Karaman, S., Erduran, E., Sahin, F., Ozdemir, G. N., Patiroglu, T., Oymak, Y., Turkkan, E., Evim, M. S., Gulen, H., Ay, Y., Okan, V., Aksu, S., Ileri, T., Salcioglu, Z., Andic, N., Yilmaz, B., Antmen, B., Albayrak, D., Oren, H., Kupesiz, A., Zengin, E., Soker, M., Ar, C., and Kavakli, K.
- Published
- 2019
5. The effects of iron deficiency on neutrophil/monocyte apoptosis in children
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Berrak, S. G., Angaji, M., Turkkan, E., Canpolat, C., Timur, C., and Eksioglu-Demiralp, E.
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- 2007
6. Deferasirox in children with transfusion-dependent thalassemia or sickle
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Antmen, B, Karakas, Z, Yesilipek, MA, Kupesiz, OA, Sasmaz, I, Uygun, V, Kurtoglu, E, Oktay, G, Aydogan, G, Akin, M, Salcioglu, Z, Vergin, C, Kazanci, EG, Unal, S, Caliskan, U, Aral, YZ, Turkkan, E, Gunes, AM, Tunc, B, Gumruk, F, Ayhan, AC, Soker, M, Koc, A, Oymak, Y, Ertem, M, Timur, C, Yildirmak, Y, Irken, G, Apak, H, Biner, B, Eren, TG, Balci, YI, Kocak, U, Karasu, G, Akkaynak, D, and Patiroglu, T
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hemoglobinopathy ,iron chelation ,iron overload ,pediatric ,transfusion - Abstract
Objectives To evaluate the long-term efficacy and safety of deferasirox therapy in a large observational cohort of children with transfusion-dependent thalassemia (TDT) and sickle cell anemia (SCA) in Turkey. Methods This was a multicenter, prospective cohort study including TDT and SCA patients aged 2-18 years with iron overload (>= 100 mL/kg of pRBC or a serum ferritin [SF] level >1000 mu g/L) receiving deferasirox. Patients were followed for up to 3 years according to standard practice. Results A total of 439 patients were evaluated (415 [94.5%] TDT, 143 [32.6%] between 2 and 6 years). Serum ferritin levels consistently and significantly decreased across 3 years of deferasirox therapy from a median of 1775.5 to 1250.5 mu g/L (P < 0.001). Serum ferritin decreases were noted in TDT (1804.9 to 1241 mu g/L), SCA (1655.5 to 1260 mu g/L), and across age groups of 2-6 years (1971.5 to 1499 mu g/L), 7-12 years (1688.5 to 1159.8 mu g/L), and 13-18 years (1496.5 to 1107 mu g/L). Serum ferritin decreases were also noted for all deferasirox dose groups but only significant in patients with doses >= 30 mg/kg/d (n = 120, -579.6 median reduction, P < 0.001). Only 9 (2%) patients had adverse events suspected to be related to deferasirox. Serum creatinine slightly increased but remained within the normal range. Conclusions Deferasirox has long-term efficacy and safety in children with TDT and SCA, although higher doses (>= 30 mg/kg/d) may be required to achieve iron balance. C1 [Antmen, Bulent] Acibadem Hosp, Adana, Turkey. [Karakas, Zeynep] Istanbul Univ, Med Fac, Istanbul, Turkey. [Yesilipek, Mehmet Akif; Kupesiz, Osman Alphan] Akdeniz Univ, Med Fac, Antalya, Turkey. [Sasmaz, Ilgen] Cukurova Univ, Med Fac, Adana, Turkey. [Uygun, Vedat; Kurtoglu, Erdal] Antalya Training & Res Hosp, Antalya, Turkey. [Oktay, Gonul] Antakya State Hosp, Antakya, Turkey. [Aydogan, Gonul; Salcioglu, Zafer] Kanuni Sultan Suleyman Training & Res Hosp, Istanbul, Turkey. [Akin, Mehmet] Denizli State Hosp, Denizli, Turkey. [Vergin, Canan] Dr Behcet Uz Child Dis Surg Training & Res Hosp, Izmir, Turkey. [Kazanci, Elif Guler] Dortcelik Child Dis Hosp, Bursa, Turkey. [Unal, Selma] Mersin Univ, Med Fac, Mersin, Turkey. [Caliskan, Umran] Necmettin Erbakan Univ, Meram Med Fac, Konya, Turkey. [Aral, Yusuf Ziya] Adnan Menderes Univ, Med Fac, Aydin, Turkey. [Turkkan, Emine] Okmeydani Training & Res Hosp, Istanbul, Turkey. [Gunes, Adalet Meral] Uludag Univ, Med Fac, Bursa, Turkey. [Tunc, Bahattin] Hematol Oncol Training & Res Hosp, Ankara Child Hlth & Dis, Ankara, Turkey. [Gumruk, Fatma] Hacettepe Univ, Med Fac, Ankara, Turkey. [Ayhan, Aylin Canbolat; Timur, Cetin] Goztepe Training & Res Hosp, Istanbul, Turkey. [Soker, Murat] Dicle Univ, Med Fac, Diyarbakir, Turkey. [Koc, Ahmet; Oymak, Yesim] Harran Univ, Med Fac, Sanliurfa, Turkey. [Ertem, Mehmet] Ankara Univ, Fac Med, Ankara, Turkey. [Yildirmak, Yildiz] Sisli Etfal Training & Res Hosp, Istanbul, Turkey. [Irken, Gulersu] Dokuz Eylul Univ, Med Fac, Izmir, Turkey. [Apak, Hilmi] Istanbul Univ, Cerrahpasa Med Fac, Istanbul, Turkey. [Biner, Betul; Eren, Tugba Gurleyen] Trakya Univ, Med Fac, Edirne, Turkey. [Balci, Yasemin Isik] Pamukkale Univ, Med Fac, Denizli, Turkey. [Kocak, Ulker] Gazi Univ, Med Fac, Ankara, Turkey. [Karasu, Gulsun] Istanbul Zeynep Kamil Women & Childrens Dis Raini, Istanbul, Turkey. [Akkaynak, Diyar] Novartis Saglik Gida & Tarim Urunleri San & Tic A, Istanbul, Turkey. [Patiroglu, Turkan] Erciyes Univ, Med Fac, Kayseri, Turkey.
- Published
- 2019
7. OUTCOME OF CHILDREN TREATED FOR RELAPSED ACUTE LYMPHOBLASTIC LEUKEMIA IN TURKEY
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Cetin, M., Hazar, V., CELKAN, Tülin Tıraje, Aydogan, G., SARPER, NAZAN, Ozdemir, M. A., Bor, O., Ozbek, N., Guler, E., Caliskan, U., Vergin, C., Aksoylar, S., Kaya, Z., Karapinar, D. Y., Turkkan, E., Buyukavci, M., Oren, H., and Timur, C.
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- 2013
8. Antioxidant and antibacterial effects of carotenoids extracted from rhodotorula glutinis strains
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Keceli T.M., Erginkaya Z., Turkkan E., Kaya U., and Çukurova Üniversitesi
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Antibacterial ,Carotenoid ,Rhodotorula glutinis ,food and beverages ,Antioxidant ,Yeast - Abstract
In this study, carotenoids extracted from the yeast twenty different Rhodotorula glutinis strains (M1-M47) isolated from soil, plant, pine and tree leaves, grape, aubergine, pee, parsley and carrot were studied for their antibacterial and antioxidant activity. Carotenoid contents of Rhodotorula glutinis strains changed between 0.23 to 1.23 mg L-1. Most of the carotenoids extracted from Rhodotorula glutinis strains (sixteen out of twenty) showed both antioxidant and antibacterial effects. Carotenoids extracted from Rhodotorula glutinis strains No. 2, 25, 26 did not show any antimicrobial activity and strains No. 1, 33 and 41 did not show any antioxidant effect. Strain No. M38 (0.74 mg L-1) was not effective neither as antibacterial nor antioxidant. The results strongly suggested that the potential utility of carotenoid synthesizing yeast Rhodotorula spp as an alternative source of natural preservatives (antioxidant and antimicrobial), carotenoid pigments (colourants) and nutraceuticals.
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- 2013
9. Molecular Structure and Vibrational Spectra of Alpha Benzoinoxime by Density Functional Method
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Gulluoglu, M T, DERELİ, ÖMER, ERDOĞDU, YUSUF, Sundaraganesan, N, Turkkan, E, Sayın, Ü, and Özmen, A
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- 2011
10. Interaction between design studio and curriculum courses: Bilkent Uiversity case
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Turkkan, E. E., Basa, I., and Gurel, M. O.
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Design education ,Curricular integration ,ComputingMilieux_COMPUTERSANDEDUCATION ,Design studio ,Lecture courses - Abstract
A major aim of the design studio is to educate students to be well-equipped designers. To do so, a student should be able to grasp the divergent information of various courses and integrate that knowledge into their design problems. But are students aware of the emphasis placed on incorporating different curriculum courses into the design studio? Do they find it beneficial while developing a design project? To what extent do they think this integration has an impact on their success in the design studio and in their adaptation to professional practice? This paper seeks to find out whether the integration between the design studio and other curriculum courses is productive from students' perspectives and determine if there is a consensus between students and instructors on the significance of transferring knowledge from curriculum courses to design projects. In addition, the paper examines the position of the design studio as an integrative medium between education and practice in the Turkish context.
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- 2010
11. Deregulated WNT signaling in childhood T-cell acute lymphoblastic leukemia
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Ng, O H, primary, Erbilgin, Y, additional, Firtina, S, additional, Celkan, T, additional, Karakas, Z, additional, Aydogan, G, additional, Turkkan, E, additional, Yildirmak, Y, additional, Timur, C, additional, Zengin, E, additional, van Dongen, J J M, additional, Staal, F J T, additional, Ozbek, U, additional, and Sayitoglu, M, additional
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- 2014
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12. Density functional theory – electron paramagnetic resonance study of gamma-irradiated single crystal of amphi-chloroglyoxime
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Turkkan, E., primary, Dereli, O., additional, Tasdemir, H. U., additional, and Cavusoglu, H., additional
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- 2009
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13. Hereditary spherocytosis with immunoglobulin a nephropathy.
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Biyikli NK, Gokce I, Cakalagaoglu F, Turkkan E, and Alpay H
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Hereditary spherocytosis is a familial hemolytic anemia. Immunoglobulin A (IgA) nephropathy associated with hereditary spherocytosis has not been reported in children. Here, we report a case of a 17-year-old boy with IgA nephropathy and hereditary spherocytosis. The patient was diagnosed with hereditary spherocytosis at the age of 12 years and splenectomy was done at the age of 15 years. Later, the patient presented with macroscopic hematuria and proteinuria. Kidney biopsy of the boy was consistent with IgA nephropathy. Treatment with angiotensin-converting enzyme inhibitor was started. The patient became free of proteinuria after the 6th month of therapy. [ABSTRACT FROM AUTHOR]
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- 2010
14. Association of depression and social anxiety symptom scores with disease characteristics in pediatric patients with chronic immune thrombocytopenia: a cross-sectional study.
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Gemici Karaaslan HB, Turkkan E, Goksoy Topal E, Karaaslan F, Dag H, and Arica V
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- Humans, Cross-Sectional Studies, Child, Male, Female, Adolescent, Child, Preschool, Quality of Life, Chronic Disease, Depression etiology, Depression diagnosis, Purpura, Thrombocytopenic, Idiopathic psychology, Purpura, Thrombocytopenic, Idiopathic diagnosis, Anxiety etiology
- Abstract
Patients with ITP have been reported to experience higher levels of depression and anxiety than their healthy counterparts. The limited research conducted on this subject in the pediatric age group has demonstrated that patients have psychosocial difficulties, and their quality of life is adversely affected. The correlation of depressive symptoms with disease characteristics of cITP has never been investigated. This was a cross-sectional study in patients being treated for cITP. Communication with participants was done during routine outpatient visits or by telephone or e-mail, and a survey about demographics and the Children's Depression Inventory (CDI) and the Social Anxiety Scale for Children-Revised (SAS-CR) was administered prospectively. A total of 56 children with cITP were recruited. The mean CDI score was 17 (SD: ± 9.44). Approximately half of the patients had higher CDI scores than healthy Turkish children. Older age, time since diagnosis, a number of hospitalizations (both total and within the last year) were positively correlated with CDI scores. There was no significant correlation between SAS-CR scores and disease characteristics. Depressive symptom scores were higher in children with cITP compared with healthy children in this study. Psychological needs may be overlooked in the medical management of children with cITP., (© 2024. Japanese Society of Hematology.)
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- 2024
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15. Evaluation of Thyroid Nodules in Patients With Fine-Needle Aspiration Biopsy.
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Turkkan E and Uzum Y
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Background: The incidence of thyroid nodules has increased in the last 50 years due to the widespread use of imaging methods and incidental detection of small thyroid nodules. Thyroid fine-needle aspiration biopsy (FNAB) is the most accurate, reliable, and cost-effective test to evaluate thyroid nodules., Aim: In this research, we aimed to elucidate thyroid fine-needle aspiration cytology (FNAC) to understand how suspicious cases predict malignancy., Materials and Methods: Within this research's scope, 411 patients over 16 years old who were evaluated in Izmir Katip Celebi University, Ataturk Training and Research Hospital Internal Medicine (Izmir, Turkey) outpatient clinic for thyroid nodules between 2018 and 2022 and underwent thyroid FNAC followed by thyroid surgery were analyzed retrospectively. The age, gender, thyroid FNAC, operation type, and histopathology of all the patients were reviewed. Individuals with a history of head and neck cancer were excluded from the analysis., Results: No statistically significant relationship between the pathology results and demographic characteristics was found. A statistically significant correlation existed between the pathology and FNAB results (p<0.05) . Although 84.5% of the patients were diagnosed as benign, 14.7% as suspicious, and 0.8% as malignant in FNAC, all of these cases were diagnosed as benign in final histopathology results. Similarly, 21.9% of the patients were diagnosed as benign, 58.8% as suspicious, and 19.4% as malignant in FNAC and all of these cases were diagnosed as malignant in final histopathology results. A correlation was determined between the two measurements (Cohen's kappa (κ)=0.557; p<0.001). The test's sensitivity was 47%, and the specificity was 99.1%. According to the FNAC results, the rate of being diagnosed with malignancy (positive predictive value (PPV)) was 93.9%, and the rate of being diagnosed as benign (negative predictive value (NPV)) was 85.8% for the individuals initially diagnosed as benign., Conclusion: Although FNAB remains the most important diagnostic tool to identify benign cases with a high accuracy rate, the operation decision is not clear in suspicious atypia of undetermined significance/follicular lesions of undetermined significance (AUS/FLUS) cytology findings. In conclusion, this study highlights the importance of FNA results and helps in surgical decision-making by emphasizing that the possibility of malignancy in the post-operative final histopathology report is higher, especially in the presence of suspicious FNAC results., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2023, Turkkan et al.)
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- 2023
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16. Predictivity of CRP, Albumin, and CRP to Albumin Ratio on the Development of Intensive Care Requirement, Mortality, and Disease Severity in COVID-19.
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Uzum Y and Turkkan E
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Background: The C-reactive protein (CRP) to albumin ratio (CAR) is a new index calculated by dividing CRP by the albumin level. It has been claimed to have predictive value in determining morbidity and mortality in many critical diseases Aim: In this research, we aimed to elucidate the importance of CRP, albumin, and CAR as parameters that can predict the clinical course in COVID-19 patients., Materials & Method: In this retrospective analysis, the clinical, laboratory, and radiological findings of patients over the age of 18 who were diagnosed with SARS-CoV-2 infection with a positive reverse transcription-polymerase chain reaction (RT-PCR) test were evaluated. Age, gender, laboratory examinations at admission, and CRP and albumin values at the time of diagnosis have been recorded. The relationship of these parameters with the requirement for intensive care, exitus, and serious illness in the clinical follow-up of the patients was investigated. The baseline hospitalization parameters of the patients were compared between the severe and non-severe groups., Results: Individuals with severe disease had a higher rate of additional disease than those with non-severe disease. It was observed that the mean laboratory values of patients with severe disease had a statistically higher level of D-dimer, CRP, aspartate aminotransferase (AST), platelet distribution width (PDW), CRP-albumin ratio, and ferritin, compared to mild to moderate cases (p<0.05). The rate of additional disease in deceased patients was higher than in patients who were alive (p<0.05). The CAR value was found to be moderately predictive in our study revealing the severity of the disease, and the possibility that the severity of the disease might be higher in patients with a CAR value above 21.47., Conclusion: The results of this study revealed that CAR is a potential parameter in distinguishing critically ill COVID-19 patients in need of intensive care. Therefore, one can say that CAR is an important biomarker in clinically determining COVID-19., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2023, Uzum et al.)
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- 2023
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17. Central Nervous System Fungal Infections in Children With Leukemia and Undergoing Hematopoietic Stem Cell Transplantation: A Retrospective Multicenter Study.
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Karaman S, Kebudi R, Kizilocak H, Karakas Z, Demirag B, Evim MS, Yarali N, Kaya Z, Karagun BS, Aydogdu S, Caliskan U, Ayhan AC, Bahadir A, Cakir B, Guner BT, Albayrak C, Karapinar DY, Kazanci EG, Unal E, Turkkan E, Akici F, Bor O, Vural S, Yilmaz S, Apak H, Baytan B, Tahta NM, Güzelkucuk Z, Kocak U, Antmen B, Tokgöz H, Fisgin T, Özdemir N, Gunes AM, Vergin C, Unuvar A, Ozbek N, Tugcu D, Bay SB, Tanyildiz HG, and Celkan T
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- Child, Humans, Retrospective Studies, Antifungal Agents therapeutic use, Hematopoietic Stem Cell Transplantation adverse effects, Hematopoietic Stem Cell Transplantation methods, Invasive Fungal Infections diagnosis, Invasive Fungal Infections drug therapy, Invasive Fungal Infections etiology, Central Nervous System Fungal Infections diagnosis, Central Nervous System Fungal Infections therapy, Leukemia drug therapy
- Abstract
Background: Central nervous system fungal infections (CNSFI) are seen in patients with hematologic malignancies and have high morbidity and mortality. Because of their rarity, there is limited data on CNSFI in children with no established treatment protocols or guidelines., Materials and Methods: In this multicenter retrospective study, 51 pediatric patients with leukemia, 6 of whom had undergone bone marrow transplantation, with proven or probable CNSFI were evaluated. Fungal infections were defined as proven or probable based on European Organisation for Research and Treatment of Cancer criteria. Proven CNSFI was diagnosed by appropriate central nervous system (CNS) imaging or tissue sample findings in combination with positive microbiological results of cerebrospinal fluid. A positive culture, microscopic evidence of hyphae, a positive result of the galactomannan assays are defined as positive microbiological evidence. Probable CNSFI was defined as appropriate CNS imaging findings together with proven or probable invasive fungal infections at another focus without CNS when there is no other explanatory condition. Data was collected by using the questionnaire form (Supplemental Digital Content 1, http://links.lww.com/JPHO/A541 )., Results: Seventeen patients had proven, 34 patients had probable CNSFI. Headaches and seizures were the most common clinical findings. The median time between the onset of fever and diagnosis was 5 days. The most common fungal agent identified was Aspergillus . Sixteen patients received single-agent, 35 received combination antifungal therapy. Surgery was performed in 23 patients. Twenty-two patients (43%) died, 29 of the CNSFI episodes recovered with a 20% neurological sequelae., Conclusion: CNSFIs should be considered in the differential diagnosis in patients with leukemia and refractory/recurrent fever, headache, neurologicalocular symptoms, and a radiologic-serological evaluation should be performed immediately. Early diagnosis and prompt management, both medical and surgical, are essential for improving clinical outcomes., Competing Interests: The authors declare no conflict of interest.
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- 2022
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18. The time to diagnosis and survival in children with solid tumors and lymphoma: results from a single center in Turkey.
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Ocak S, Sen HS, and Turkkan E
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- Child, Delayed Diagnosis, Humans, Time Factors, Turkey epidemiology, Lymphoma diagnosis, Lymphoma therapy, Neoplasms diagnosis, Neoplasms therapy
- Abstract
The longer diagnostic intervals in low- and middle-income countries have been proposed among the possible causes of poorer outcomes in children with cancer. In this single-center study from Turkey, the diagnostic intervals and survival status of 138 children with solid tumors and lymphoma (excluding leukemia) were prospectively evaluated. The median total interval (from the beginning of the first cancer-related symptom to the first day of the cancer-specific therapy), the median patient interval (the time interval from the notification of the first cancer-related symptom to the first admission to a healthcare facility), and the median physician interval (the time interval between the first healthcare admission to the first pediatric oncology visit) were 65, 26, and 24 days, respectively. The estimated 5-year overall survival and event-free survival rates were 80.7% and 69.1%, respectively. The longer time intervals were correlated with age, paternal education, localization, and tumor type. Interestingly, none of the time parameters were found to be associated with survival on regression analysis. In conclusion, the diagnostic delay in children with cancer is multifactorial, and the patient- and disease-related factors are as important as the time intervals on survival.Supplemental data for this article is available online at https://doi.org/10.1080/08880018.2021.1951903.
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- 2022
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19. Children's only profession: Playing with toys.
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Dag NC, Turkkan E, Kacar A, and Dag H
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The concepts of games and toys have a very important role in children's lives. It contributes to the development of cognitive, motor, psychosocial, emotional, and linguistic skills. It also plays a key role in raising self-confident, creative, and happy children. Therefore, attention should be paid to the concepts of games and toys, which are so important for the child to be a part of society as a healthy individual at every stage of his development. On the other hand, providing playgrounds where children can play comfortably and safely are essential in reducing the risk of accidents related to toys. All health-care components, especially pediatricians and family physicians, should take an active role in ensuring that these play processes, which are the most beautiful parts of childhood, are healthy and safe., Competing Interests: Conflict of Interest: No conflict of interest was declared by the authors., (Copyright: © 2021 by Istanbul Northern Anatolian Association of Public Hospitals.)
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- 2021
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20. Ophthalmologic findings and complications before and after hematopoietic stem cell transplantation: single-center study.
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Sarbay H, Hagverdiyeva S, Turkkan E, Akcay S, Atay A, and Malbora B
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- Child, Cyclosporine, Female, Humans, Male, Retrospective Studies, Transplantation Conditioning adverse effects, Graft vs Host Disease etiology, Graft vs Host Disease prevention & control, Hematopoietic Stem Cell Transplantation adverse effects
- Abstract
Purpose: Different and various system complications and late effects may occur after hematopoietic stem cell transplantation (HSCT). It was aimed to obtain information about the frequency of ophthalmologic complications and their relationship with treatment., Methods: This retrospective study includes 104 children who underwent HSCT between February 2019 and June 2020 at the Pediatric Bone Marrow Transplant Unit. Patients' ages, genders, diagnosis, transplant types, chemotherapy regimens, transplantation details, conditioning regimens, supportive cares, graft versus host disease (GvHD) prophylaxis, infection episodes, and ophthalmologic findings were evaluated., Results: Of the 104 patients included in the study, 38 (36.5%) were female and 66 (63.5%) were male. Average age ± SD was 8.7 ± 4.91. Considering the diagnoses, the majority of the patients were acute lymphoblastic leukemia (46 patients-44%). Myeloablative regimen was used in 93 (89%) of the patients, and reduced intensity conditioning (RIC) was used in 11 patients (10%). While total body irradiation was applied in 16 (15%) patients, one patient was received cranial radiotherapy. Cyclosporine was used in 96 (92%) patients. CMV reactivation was detected in 54 (51%) of the patients. CMV retinitis was not seen. Ocular pathology was detected in 20 (19%) patients before HSCT and in 12 (11%) patients after HSCT. The most common pathology was dry eye., Conclusion: Routine ophthalmologic examinations are important in terms of early diagnosis. In addition, GvHD and CMV prophylaxis is important because of reducing the risk of ocular complications after HSCT.
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- 2021
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21. Evaluation of PAX5 gene in the early stages of leukemic B cells in the childhood B cell acute lymphoblastic leukemia.
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Firtina S, Sayitoglu M, Hatirnaz O, Erbilgin Y, Oztunc C, Cinar S, Yildiz I, Celkan T, Anak S, Unuvar A, Devecioglu O, Timur C, Aydogan G, Akcay A, Atay D, Turkkan E, Karaman S, Orhaner B, Sarper N, Deniz G, and Ozbek U
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- B-Lymphocytes pathology, Cell Line, Cell Transformation, Neoplastic genetics, Cell Transformation, Neoplastic pathology, Child, Child, Preschool, Cohort Studies, Female, Gene Expression Regulation, Leukemic, Humans, Infant, Male, Mutation, Neoplasm Staging, PAX5 Transcription Factor metabolism, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma immunology, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma pathology, Protein Isoforms genetics, Protein Isoforms metabolism, B-Lymphocytes metabolism, PAX5 Transcription Factor genetics, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma genetics
- Abstract
B-lineage acute lymphoblastic leukemia (B-ALL) is a common subtype of acute leukemia in children. PAX5 plays a central role in B-cell development and differentiation. In this study, we analyzed PAX5 expression levels, transactivation domain mutations/deletions in B-ALL patients (n=115) and healthy controls (n=10). Relative PAX5 mRNA levels were significantly increased in B-ALL patients (p<0.0001). PAX5 expression was also evaluated in three different B-ALL subgroups (pro B, Common B and Pre B ALL) and showed stage specific expression levels. Pro B (p=0.04) and pre B (p=0.04) patients showed significantly high PAX5 mRNA levels compared to stage specific controls. At least one deletion of exons 7-8 or 9 has been identified in the 41% of the patients. CD34 positivity in patients and presence of large deletions (Δ7/8/9) showed a significant correlation (p=0.05). None of our patients showed PAX5 point mutations, but two previously identified SNPs (rs3780135 and rs35469494) were detected. Our results support that PAX5 is a critical factor in B-ALL development and aberrant PAX5 expression especially at early stages may leads to leukemic transformation., (Copyright © 2011 Elsevier Ltd. All rights reserved.)
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- 2012
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22. Ground-glass-like hepatocellular inclusions in the course of adult-onset Still's disease.
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Sari A, Tunakan M, Ozmen M, and Turkkan E
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- Administration, Oral, Adult, Diabetes Mellitus drug therapy, Drug Therapy, Combination, Fatty Liver complications, Female, Glucocorticoids therapeutic use, Humans, Injections, Subcutaneous, Insulin therapeutic use, Liver Function Tests, Still's Disease, Adult-Onset complications, Still's Disease, Adult-Onset drug therapy, Fatty Liver pathology, Hepatocytes pathology, Inclusion Bodies pathology, Still's Disease, Adult-Onset pathology
- Abstract
Ground-glass hepatocytes are the cardinal biopsy feature of chronic hepatitis B virus (HBV) infection and may also be present in other specific conditions, including Lafora's disease, cyanamide aversion therapy for alcohol use, patients with transplantation, uremia, and metabolic disorders. In this report, we present the case of a patient with adult-onset Still's disease who underwent percutaneous liver biopsy, which revealed ground-glass-like cytoplasmic inclusions and which is a very unusual finding.
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- 2010
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23. Does Helicobacter pylori-induced inflammation of gastric mucosa determine the severity of symptoms in functional dyspepsia?
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Turkkan E, Uslan I, Acarturk G, Topak N, Kahraman A, Dilek FH, Akcan Y, Karaman O, Colbay M, and Yuksel S
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- Adult, Aged, Dyspepsia classification, Dyspepsia microbiology, Female, Gastric Mucosa microbiology, Gastric Mucosa pathology, Helicobacter Infections microbiology, Helicobacter pylori isolation & purification, Humans, Inflammation microbiology, Male, Malondialdehyde metabolism, Middle Aged, Severity of Illness Index, Sulfhydryl Compounds metabolism, Young Adult, Dyspepsia physiopathology, Helicobacter Infections physiopathology, Inflammation physiopathology, Oxidative Stress
- Abstract
Background: Inflammation induces some structural and biochemical alterations and oxidative damage in gastric tissue. In this study, we aimed to investigate the relationship among the severity of symptoms, oxidative stress, and grading scales of Helicobacter pylori-induced gastric inflammation in functional dyspepsia., Methods: Thirty-five patients with functional dyspepsia were enrolled in the study. The severity of dyspepsia within the last 6 months was evaluated by Glasgow Dyspepsia Severity Score. In biopsy specimens of gastric mucosa, severity of gastritis was estimated by the revised Sydney Classification System, and oxidative stress parameters were studied., Results: Although there was no statistically significant relationship between symptom scores and degree of chronic inflammation, a tendency for symptoms to be more severe has been observed in low levels of gastritis. Levels of sulfhydryl groups were lower in subjects with high levels of chronic inflammation, and Helicobacter pylori intensity (P < 0.001 and P = 0.02, respectively). Levels of malondialdehyde were higher in subjects with high levels of chronic inflammation (P = 0.04). There was a statistically significant but a weak positive correlation between symptom scores and sulfhydryl levels (P < 0.001, r = 0.323)., Conclusions: In conclusion, there may be an inverse relation between severity of symptoms and level of Helicobacter pylori induced gastric inflammation or oxidative stress in patients with functional dyspepsia.
- Published
- 2009
- Full Text
- View/download PDF
24. A double-blind, crossover, randomized dose-comparison trial of granisetron for the prevention of acute and delayed nausea and emesis in children receiving moderately emetogenic carboplatin-based chemotherapy.
- Author
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Berrak SG, Ozdemir N, Bakirci N, Turkkan E, Canpolat C, Beker B, and Yoruk A
- Subjects
- Adolescent, Adult, Antiemetics pharmacology, Antineoplastic Agents therapeutic use, Carboplatin therapeutic use, Child, Child, Preschool, Cross-Over Studies, Double Bind Interaction, Female, Granisetron pharmacology, Humans, Infant, Male, Nausea chemically induced, Nausea drug therapy, Treatment Outcome, Vomiting chemically induced, Vomiting drug therapy, Antiemetics administration & dosage, Antineoplastic Agents adverse effects, Carboplatin adverse effects, Dose-Response Relationship, Drug, Drug-Related Side Effects and Adverse Reactions, Granisetron administration & dosage, Nausea prevention & control, Vomiting prevention & control
- Abstract
Background: Granisetron is a safe and effective prophylaxis for nausea and vomiting associated with moderate to highly emetogenic chemotherapy. Few trials have been conducted to determine the optimal effective dose of granisetron in children with cancer. The objective of this report was to compare two doses of granisetron in patients with optic pathway tumors receiving moderately emetogenic doses of carboplatin., Patients and Methods: In this double-blind, crossover, randomized study, antiemetic efficacy and tolerability of two dose levels (10 and 40 microg/kg) of granisetron in the prevention of acute and delayed nausea/emesis were compared in children and young adults. A total of 18 patients (13 boys) aged 1-23 years (median 7.7 years) treated with a moderately emetogenic dose of carboplatin were randomly assigned to receive either 10 or 40 microg/kg of slow granisetron intravenous (i.v.) infusions at alternating cycles of chemotherapy in a blinded fashion until the end of the study period or until their chemotherapy regimen ended. In this way, the patients acted as their own controls., Results: Patients in the granisetron 10 and 40 microg/kg groups received 104 and 121 cycles of chemotherapy, respectively. There was no significant difference in antiemetic efficacy in terms of nausea and emesis between the dose groups in the first 5 days of chemotherapy. The treatment was well tolerated., Conclusion: We conclude that granisetron 10 and 40 microg/kg have comparable efficacy in controlling carboplatin-induced acute and delayed nausea/emesis and is well tolerated in children and young adults.
- Published
- 2007
- Full Text
- View/download PDF
25. 5-Fluorouracil, epirubicin and cisplatin in the treatment of metastatic gastric carcinoma: a retrospective analysis of 68 patients.
- Author
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Ozkan K, Turkkan E, Ender K, Mutlu D, Murat A, Nalan B, Abdulmecit Y, and Osman M
- Subjects
- Adult, Aged, Antineoplastic Combined Chemotherapy Protocols adverse effects, Cisplatin administration & dosage, Disease-Free Survival, Drug Administration Schedule, Epirubicin administration & dosage, Female, Fluorouracil administration & dosage, Humans, India epidemiology, Liver Neoplasms drug therapy, Liver Neoplasms secondary, Lung Neoplasms drug therapy, Lung Neoplasms secondary, Lymphatic Metastasis, Male, Medical Records, Middle Aged, Neoplasm Metastasis, Ovarian Neoplasms drug therapy, Ovarian Neoplasms secondary, Peritoneal Neoplasms drug therapy, Peritoneal Neoplasms secondary, Retrospective Studies, Stomach Neoplasms pathology, Survival Analysis, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Stomach Neoplasms drug therapy
- Abstract
Background: Gastric cancer is one of the most common types of cancer and one of the most frequent causes of cancer-related death. The majority of gastric cancers show distant metastasis at the time of diagnosis. At present, there is no general agreement over one standard chemotherapy regimen for metastatic gastric cancer., Aims: We evaluated the activity and toxicity of the combination of 5-Fluorouracil (5-FU), epirubicin and cisplatin (FEP) in previously untreated patients with metastatic gastric cancer., Setting and Design: Medical Oncology Department of Uludag University Faculty of Medicine, Bursa; retrospective study., Material and Methods: Sixty-eight patients received 5-FU 300 mg/m2 on Days 1-5, epirubicin 50 mg/m2 on Day 1 and cisplatin 60 mg/m2 on Day 1, every 4 weeks. A median of 3.5 cycles was administered. The response rate, time to disease progression, survival and toxic effects were analyzed., Statistical Analysis Used: Overall survival and time to progression were estimated using Kaplan-Meier method., Results: There were 4 partial responses and 1 complete response (overall response rate 7.3%); 16 patients had stable disease. Median progression-free and overall survival rates were 3.1 months (95% CI 1.9-4) and 6 months (95% CI 4.2-7), respectively. The principal toxicity was myelosupression. Grade 3-4 neutropenia occurred in 27.9%, anemia in 17.6%, and thrombocytopenia in 11.7% of patients. Non-hematological toxicity was mild and manageable., Conclusions: We concluded that FEP combination as used at the doses and schedules in this study has inferior activity against metastatic gastric cancer.
- Published
- 2005
- Full Text
- View/download PDF
26. [Economic evaluation of the mother-child health/family planning project in Yozgat (author's transl)].
- Author
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Turkkan E and Yalniz A
- Subjects
- Asia, Asia, Western, Delivery of Health Care, Developing Countries, Health, Primary Health Care, Turkey, Health Services, Maternal-Child Health Centers
- Published
- 1981
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