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1. Is ischemia-modified albumin a reliable tool for the assessment of acute pancreatitis?

Author

Sahin A, Turkoglu S, Tunc N, Duzenci D, Arslan Solmaz O, Bahcecioglu IH, and Yalniz M

Subjects
ischemia modified albumin, adjusted ischemia modified albumin, acute pancreatitis, severity, Therapeutics. Pharmacology, RM1-950
Abstract

Abdurrahman Sahin,1 Semra Turkoglu,2 Nurettin Tunc,1 Deccane Duzenci,3 Ozgen Arslan Solmaz,4 Ibrahim Halil Bahcecioglu,1 Mehmet Yalniz1 1Medicine Faculty, Department of Gastroenterology, Firat University, Elazig, Turkey; 2Department of Nutrition and Dietetics, Health Sciences Faculty, Firat University, Elazig, Turkey; 3Department of Internal Medicine, Elazig Education and Training Hospital, Elazig, Turkey; 4Department of Pathology, Elazig Education and Training Hospital, Elazig, Turkey Purpose: Oxidative stress has been implicated in several disorders, including acute pancreatitis (AP). Ischemia-modified albumin (IMA), which reflects the ability to bind cobalt, has been found to be elevated in conditions of oxidative stress and tissue hypoxia. This study examined IMA and adjusted IMA levels in patients with AP, and examined the associations of IMA and adjusted IMA levels to the severity of AP.Patients and methods: A total of 42 consecutive patients with AP and 43 age- and sex-matched control subjects were enrolled. Serum samples were obtained from patients with AP on admission as well as 48–72 hours after hospitalization, and from the controls, at the time of enrollment. Adjusted IMA was calculated by multiplying the IMA value of each patient with the ratio of the patient’s albumin value and the median albumin value of the study population. The severity of AP was assessed according to the modified Atlanta classification, and the patients were divided into 2 groups: mild AP and severe AP.Results: The serum IMA and adjusted IMA values of patients with AP on admission and those of the controls did not differ (p=0.86 and p=0.99, respectively). The second measurements of IMA and adjusted IMA in the AP group were higher than the first measurements of both the AP group and controls (for all, p

Published
2018

9. Maternal fetal medicine-perinatology

Author

Tekcan, C., Naki, M. M., Özcan, N., Cebi, M., Kanadikirik, F., Has, R., Aydoadu, M., Frenz, J. P., Schröder, W., Dede, F. S., Kovalak, E. E., Gelisen, O., Dede, H., Sariisik, B., Haberal, A., Caliskan, E., Turkoz, E., Corakci, A., Ozeren, S., Yucesoy, I., Terzioglu, N., Köhler, W., Feige, A., Atad, J., Auslender, R., Bardicef, M., Calderon, I., Leron, E., Abramovici, H., Ertas, I. F., Kahyaoglu, S., Turgay, M., Sut, N., Yilmaz, B., Ozel, M., Danisman, N., Kocak, I., Üstün, C., Bese, E., Ingec, M., Borekci, B., Yilmaz, M., Kadanali, S., Ingec, M., Kadanali, S., Erdogan, F., Kumtepe, Y., Gümüs, I. I., Turhan, N. O., Tamburaci, E., Gunduz, O., Akar, M., Simsek, M., Zorlu, G., Ingec, M., Borekci, B., Kadanali, S., Balci, O., Gezginc, K., Acar, A., Akyürek, C., Kocak, I., Üstün, C., Bese, E., Biri, A., Guler, I., Himmetoglu, O., Karaoguz, M. Y., Balci, Sevim, Tanriverdi, H. A., Usal, D., Cinar, E., Barut, A., Pilanci, B., Imren, A., Öztekin, D., Kurt, S., Tinar, S., Canoruc, N., Kale, A., Kale, E., Yalinkaya, A., Akdeniz, N., Gol, M., Tuna, B., Guclu, S., Altunyurt, S., Demir, N., Biri, A., Ciftci, B., Senol, E., Haznedarohlu, S., Gucuyener, K., Gursoy, R., Kahyaoglu, S., Turgay, I., Gocmen, M., Yilmaz, B., Neslihanoglu, R., Danisman, N., Kahyaoglu, S., Turgay, I., Gocmen, M., Yilmaz, B., Ozel, M., Danisman, N., Kahyaoglu, S., Turgay, I., Kokanali, M. K., Kunt, C., Yapar, E. G., Taskin, S., Yarci, A., Bozaci, E. A., Atabekoglu, C., Söylemez, F., Taskin, S., Seval, M., Bozaci, E. A., Özmen, B., Mammadova, S., Unlü, C., Seval, M., Taskin, S., Özmen, B., Güleryüz, D., Sahincioglu, Ö., Unlü, C., Öztürk, N., Yalvac, S., Caliskan, E., Erten, A., Dölen, I., Haberal, A., Gul, A., Cebeci, A., Gedikbasi, A., Erol, O., Ceylan, Y., Tekirdag, A. I., Onan, M. A., Turp, A., Kurdoglu, M., Gunaydin, G., Kurdoglu, Z., Guler, I., Erdem, A., Himmetoglu, O., Tulumbaci, O., Onan, M. A., Turkoglu, S., Kurdoglu, M., Boyaci, B., Tiras, M. B., Kurdoglu, Z., Gunaydin, G., Kadayifci, O., Demir, S. C., Ürünsak, I. F., Özgünen, T., Evrüke, I. C., Demir, S. C., Evrüke, I. C., Özgünen, T., Kadayifci, O., Güzel, A. B., Urünsak, I. F., Uckuyu, A., Ozcimen, E. E., Nisanoglu, O., Yanik, F., Akgun, S., Kuscu, E., Sayin, N. C., Canda, M. T., Ahmet, N., Kurt, I., Varol, F. G., Erkanli, S., Caliskan, K., Bagis, T., Kilicdag, E., Tarim, E., Kuscu, E., Tutuncu, L., Ardic, N., Mungen, E., Ergur, A. R., Yergok, Y. Z., Cölcimen, N., Sahin, H. G., Kamaci, M., Bezircioglu, I., Bicer, M., Uysal, D., Yigit, S., Baloglu, A., Bezircioglu, I., Bicer, M., Karci, L., Ozder, F., Baloglu, A., Has, R., Yüksel, A., Büyükkurt, S., Tatli, B., Kalelioglu, I., Kesim, M. D., Aydin, Y., Atis, A., Gezer, A., Erkan, S., Simsek, Y., Kahraman, N., Uludag, S., Altinok, T., Kale, A., Erdemoglu, M., Akdeniz, N., Ozcan, Y., Yalinkaya, A., Köse, G., Tuncel, T., Aka, N., Kumru, P., Güven, M. A., Ciragil, P., Tutuncu, L., Ozdemir, E., Mungen, E., Ergur, A. R., Yergok, Y. Z., Güven, M. A., Aktan, E., Bozkurt, K., Güven, M. A., Kilinc, M., Ekerbicer, H., Güven, M. A., Ceylaner, S., Ceylaner, G., Gul, D., Ertas, E., Güven, M. A., Ceylaner, S., Batukan, C., Ozbek, A., Demirpolat, G., Uzel, M., Basaran, A., Bozdag, G., Dagdelen, S., Gürlek, A., Beksac, S., Arici, Özkan A., Isparta, T., Dikis, F. C., Civas, S. B., Ispahi, C., Kalelioalu, I. K., Has, R., Yüksel, A., Gilbaz, E., Ibrahimoglu, L., Ermis, H., Yildirim, A., Dane, B., Yayla, M., Dane, C., Özek, M., Kalelioglu, I. K., Has, R., Yüksel, A., Gilbaz, E., Ibrahimoglu, L., Ermis, H., Yildirim, A., Dane, B., Yayla, M., Cem, Dane, Salih, Dural, Dane, C., Yayla, M., Dane, B., Cetin, A., Kiray, M., Dane, B., Yayla, M., Dane, C., Ataoglu, E., Döventas, Y., Delier, H., Has, R., Kalelioglu, I., Büyükkurt, S., Has, R., Kalelioglu, I. K., Yüksel, A., Gilbaz, E., Ibrahimoglu, L., Ermis, H., Yildirim, A., Has, R., Kalelioglu, I. K., Yüksel, A., Gilbaz, E., Ibrahimoglu, L., Ermis, H., Yildirim, A., Yildiz, A., Köksal, A., Celik, N., Yetimalar, H., Keklik, A., Ivit, H., Cukurova, K., Hizli, D., Dilbaz, S., Acer, N., Deveci, S., Dilbaz, B., Haberal, A., Cukurova, K., Köksal, A., Yilmaz, S., Ivit, H., Yildiz, A., Yetimalar, H., Keklik, A., Bicer, Bulbul M., Karakaya, E., Pehlivan, M., Baloglu, A., Caliskan, E., Doger, E., Duman, C., Turker, G., Ozeren, S., Yucesoy, I., Caliskan, E., Doger, E., Cakiroglu, Y., Corakci, A., Ozeren, S., Caliskan, E., Turkoz, E., Ozeren, S., Corakci, A., Ozkan, S., Yucesoy, I., Caliskan, E., Cakiroglu, Y., Dundar, D., Doger, E., Caliskan, S., Ozeren, S., Cukurova, K., Köksal, A., Ivit, H., Yetimalar, H., Yildiz, A., Keklik, A., Aksakalli, V., Cukurova, K., Köksal, A., Önal, G., Yildiz, A., Ivit, H., Keklik, A., Yetimalar, H., Kesim, M. D., Demirkaya, B. Ö., Atis, A., Yavuz, M., Bozkurt, T., Ozyuncu, O., Bozdag, G., Salman, M. C., Durukan, T., Beksac, S., Onderoglu, L., Deren, O., Ayhan, A., Tufekci, C., Karalök, H., Ilter, E., Cil, L., Karalök, A. E., Akyol, H., Kesim, M. D., Demirkaya, B. Ö., Atis, A., Oruc, Ö., Ekin, M., Ülku, M., Caglar, P., Demirel, C., Güngör, T., Mollamahmutoglu, L., Usta, T., Özdemir, B., Ates, U., Numanoglu, N., Seyhan, A., Sidal, B., Akdeniz, N., Kale, A., Erdemoglu, M., Ozcan, Y., Yalinkaya, A., Ozdemir, B., Numanoglu, N., Usta, T., Ortakuz, S., Seyhan, A., Sidal, B., Seyhan, A., Numanoglu, N., Usta, T., Ortakuz, S., Öztarhan, A., Özdemir, B., Dogan, O., Ilbaz, S., Kovalak, E. E., Tarcan, A., Sariisik, B., Sivaslioglu, A., Haberal, A., Cinar, E., Tanriverdi, H. A., Akbulut, V., Sade, H., Barut, A., Dede, A., Özel, M., Günaydin, S., Ertas, E., Danisman, N., Mollamahmutoglu, L., Ates, U., Seyhan, A., Atmaca, U., Ortakuz, S., Ata, B., Akar, S., Sidal, B., Tanriverdi, H. A., Akbulut, V., Usal, D., Cinar, E., Barut, A., Vural, B., Özkan, S., Costur, P., Dalcik, H., Filiz, S., Yücesoy, I., Erdemoglu, E., Kolusari, A., Sahin, H. G., Kamaci, M., Sahin, A. V., Vural, B., Özkan, S., Tas, A., Dalcik, C., Dalcik, H., Yücesoy, G., Unlubilgin, E., Caliskan, E., Demir, B., Dilbaz, S., Sonmezer, M., Haberal, A., Erdem, M., Turp, A., Gunaydin, G., Erdem, A., Sade, H., Tanriverdi, H. A., Gezer, S., Bayar, Ü., Barut, A., Demir, B., Demir, F., Yayla, M., Api, O., Aygün, E., Kars, B., Cengizoglu, B., Bulut, S., Turan, C., Unal, O., Api, O., Ünal, O., Karageyim, Y. K., Balcik, O., Kara, Ö., Dogance, U., Akil, A., Api, M., Balsak, D., Avci, M. E., Elveren, B., Hanhan, M., Kayhan, K., Tinar, S., Ispahi, C., Mollamahmutoglu, L., Güngör, T., Özdal, B., Cavkaytar, S., Özat, M., Demirel, C., Aksakal, O., Caliskan, E., Unlubilgin, E., Cakiroglu, Y., Dilbaz, B., Dilbaz, S., Dilbaz, S., Caliskan, E., Dilbaz, B., Ozdas, E., Filiz, T., Haberal, A., Asian, E., Tarim, E., Kilicdag, E., Haydardedeoglu, B., Kuscu, E., Asian, E., Kilicdag, E., Simsek, E., Bolat, F., Haydardedeoglu, B., Ocak, S., Zeteroglu, S., Deveci, A., Gungoren, A., Borazan, E., Hakverdi, A., Zeteroglu, S., Ocak, S., Deveci, A., Gungoren, A., Andi, A., and Hakverdi, A.

Published
2005
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14. TT Virus Infection and Genotype Distribution in Blood Donors and a Group of Patients from Turkey

Author

Erensoy, S., SayA+-ner, A. A., Turkoglu, S., Canatan, D., Akarca, U. S., Sertoz, R., Ozacar, T., Batur, Y., Badur, S., and Bilgic, A.

Subjects
Hepatitis -- Care and treatment, TT virus -- Genetic aspects, TT virus -- Control, Health
Abstract

Byline: S. Erensoy (1), A. A. SayA+-ner (2), S. Turkoglu (3), D. Canatan (4), U. S. Akarca (5), R. Sertoz (1), T. Ozacar (1), Y. Batur (5), S. Badur (3), A. Bilgic (1) Abstract: Background: TT virus (TTV) DNA has been found in a large proportion of patients with different forms of non-A-G hepatitis, however the clinical importance is unclear. We aimed to determine the genotypes of TTV isolates foung in blood donors and different patient groups from the western part of Turkey. Materials and Methods: TT DNA was investigated in serum samples of 91 volunteer blood donors (BD), 105 thalassemia (TH) patients, ten patients with fulminant hepatitis (FH) and 16 hemodialysis (HD) patients by heminested PCR using primers NG059, NG061 and NG063 from the ORF1 region. 39 isolates were genotyped by analyzing the partial sequence of ORF1. Results: TTV DNA was found in 75% of HD, 80% of FH, 61% of TH patients and in 51.6% of BD. Among the sequenced isolates, 14 (35.9%) belonged to genotype 1 (G1) and 25 (64.1%) belonged to genotype 2 (G2). Among the G2 sequences, 22 were grouped as G2c. Conclusion: TTV infection was common in the population studied, even with moderately sensitive primers. G2 was the major genotype of the studied population without any significant differences in distribution between various patient groups and BD. Author Affiliation: (1) Dept. of Microbiology and Clinical Microbiology, Medical Faculty, Ege University, Bornova, 35100 Izmir, Turkey. erensoy@med.ege.edu.tr, TR (2) Dept. of Microbiology and Clinical Microbiology, Medical Faculty, Dokuz Eylul University, Izmir, Turkey, TR (3) Dept. of Microbiology and Clinical Microbiology, Medical Faculty, Istanbul University, Turkey, TR (4) Suleyman Demirel University, Dept. of Pediatric Hematology, Isparta, Turkey, TR (5) Dept. of Gastroenterology, Medical Faculty, Ege University, Turkey, TR Article note: Received: December 27, 2001 * Revision accepted: April 4, 2002 S. Erensoy (corresponding author)

Published
2002

17. Asprosin, visfatin and subfatin as new biomarkers of obesity and metabolic syndrome.

Author

UGUR, K., ERMAN, F., TURKOGLU, S., AYDIN, Y., AKSOY, A., LALE, A., KARAGÖZ, Z. K., UGUR, İ., AKKOC, R. F., and YALNIZ, M.

Abstract

OBJECTIVE: Metabolic syndrome (MetS) and obesity are important public health problems associated with adipose tissue mass. Asprosin, visfatin, and subfatin are new members of which fate in MetS and obesity has not been fully revealed yet. Thus, this study was to investigate the association between asprosin, visfatin, subfatin, and biochemical values, demographic data, and body composition measurement values in MetS patients with and without obesity. PATIENTS AND METHODS: Blood samples were taken from a total of 90 people, including 31 MetS patients with obesity, 29 MetS patients without obesity, and 30 healthy (control). Asprosin, visfatin, and subfatin were studied by the ELISA method. RESULTS: There was a negative correlation between asprosin and Body Mass Index (BMI) in the MetS + Obese group. The correlations between asprosin and urea and fasting insulin (FI) levels in the MetS group were positive and statistically significant (p < 0.05). While there was a statistically significant negative correlation (p < 0.05) between visfatin and BMI in the MetS + Obese group, the correlation with waist circumference in the MetS + Obese and MetS groups was statistically significant and negative (p < 0.05). There was a statistically significant negative relationship (p < 0.05) between aspartate aminotransferase value and visfatin. The results between visfatin values and asprosin and subfatin in all groups were significant (p < 0.05). CONCLUSIONS: There is a direct relationship between circulating amounts of asprosin, visfatin visfatin, and subfatin hormones and age, weight, height, diastolic blood pressure, high-density lipoprotein-cholesterol, aspartate aminotransferase, alanine transaminase, and creatinine. Therefore, asprosin, visfatin, and subfatin hormones are the new biomarkers of metabolic turbulence. [ABSTRACT FROM AUTHOR]

Published
2022

18. Hepatoprotective effects of safranal on acetaminophen-induced hepatotoxicity in rats

Author

Alayunt Naci Ömer, Parlak Akif Evren, Türkoğlu Semra, and Taş Fatih

Subjects
antioxidant, inflammation, liver injury, oxidative stress, safranal, Chemistry, QD1-999
Abstract

This research aimed to explore the protective and therapeutic properties of safranal in mitigating inflammation and oxidative stress induced by elevated acetaminophen (APAP) doses in a rat model. The protective and therapeutic effects of safranal were determined by histopathologically and examining some biochemical parameters such as aspartate transaminase (AST), alanine transaminase (ALT), glutathione, glutathione peroxidase, catalase, malondialdehyde, interleukin-6, tumor necrosis factor-α, and interleukin-1β. Male Wistar–Albino rats were subject to random allocation, forming five groups, each comprising seven rats (n = 7) in the study. Group 1 was the control group. APAP was administered in Group 2 to induce hepatotoxicity. Rats in Groups 3, 4, and 5 received intraperitoneal injections of safranal at doses of 0.025, 0.05, and 0.1 mL/kg/day for 14 days, respectively. On the 15th day, to induce APAP-induced hepatotoxicity, four groups (Groups 2, 3, 4, and 5) acquired a single intraperitoneal injection of 600 mg/kg APAP. The presence of APAP-induced hepatotoxic effect was proven by elevated AST and ALT levels, which are typical biomarkers of liver function in addition to the demonstration of histopathological changes. The findings suggest that pre-treatment with safranal may offer a protective effect against hepatotoxicity by attenuating oxidative stress and the inflammatory response.

Published
2024
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19. The effects of some bis - 1, 2, 4 - Triazole containing aminomethyl derivatives on mda levels and vitamins in tissues of rats

Author

Alayunt N.O., Karatepe M., Parlak A.E., Ulas M., Turkoglu S., Dastan S.D., Celik S., and Uşak Üniversitesi

Subjects
Liver, Malondialdehyde (A, E and C) Vitamins, Kidney, 1,2,4 - triazole, Aminomethyl derivatives
Abstract

Summary: It was reported that the 1, 2, 4-triazole and the derivatives of this compound demonstrate numerous activities in a pharmacological point of view. 1, 2, 4-Triazole moieties were employed in an extensive range of drug candidates, which are therapeutically promising and include anti-inflammatories, anti-anxiety compounds, sedatives, CNS stimulants, antimicrobial agents, and antimycotic ones such as intraconazole, fluconazole and voriconazole. In the current investigation, several aminomethyl derivatives, which contain bis-1, 2, 4-triazole, were newly synthesized and their impacts on the levels of antioxidant vitamins (A, C and E) and malondialdehyde (MDA) were examined in serum, kidney and liver of rats. The investigation of the levels of the vitamins (A, C and E) and malondialdehyde (MDA) were performed by calculations in HPLC system. In the study, the observed antioxidant activity revealed that all the analyzed compounds, have promising antioxidant activities, which may be the result of the presence of benzylpiperazine and dipropylamine, and a methylpiperidine moiety as well as the allyl group. Therefore, it was concluded that ample scope exists for further studies. © 2019 Chemical Society of Pakistan. All rights reserved.

Published
2019

20. Relationship between some element levels and oxidative stress parameters in rats liver treated with hydroxyurea derivative compounds

Author

Karagozoglu Y., Parlak A.E., Alayunt N.Ö., Turkoglu S., Yildirim I., Karatepe M., and Uşak Üniversitesi

Subjects
Liver, Oxidative stress, Hydroxyurea, Rat, Some element
Abstract

In this study, effects of hydroxyurea derivatives 1, 3, 4 - thiadiazole and schiff base compounds on some element levels and antioxidant enzyme activities in rat liver and on antioxidant enzyme levels that are parameters of oxidative stress were investigated. For this purpose, iron (Fe), zinc (Zn) and copper (Cu) concentrations were analyzed by using atomic absorption spectroscopy superoxide dismutase (SOD) and catalase (CAT) activities were measured by using a UV spectrophotometer. Fe, Zn and Cu concentrations in the liver of rats treated with these compounds were compared with levels of SOD and CAT statistically. As a result, the increase in the antioxidant activities of SOD and CAT metalloenzymes together with decrease in levels of Cu, Zn and Fe elements observed may suggest that the elements be bound to these enzymes. © 2019 Suleyman Demirel University. All rights reserved.

Published
2019

23. Investigation of biological effects of some Mannich Bases containing Bis-1,2,4- Triazole

Author

AKIF EVREN PARLAK, Celik S, Karatepe M, Turkoglu S, No, Alayunt, Sd, Dastan, Ulas M, Sandal S, Tekin S, Koparir M, [Parlak, A. E.] Firat Univ, Keban Vocat High Sch, TR-23740 Elazig, Turkey -- [Celik, S.] Usak Univ, Fac Dent, Usak, Turkey -- [Karatepe, M. -- Koparir, M.] Firat Univ, Dept Chem, Fac Sci, TR-23119 Elazig, Turkey -- [Turkoglu, S.] Firat Univ, Fac Hlth Sci, TR-23119 Elazig, Turkey -- [Alayunt, N. O.] Usak Univ, Banaz Vocat High Sch, TR-64200 Usak, Turkey -- [Dastan, S. D.] Cumhuriyet Univ, Fac Vet Med, Dept Biometr & Genet, TR-58140 Sivas, Turkey -- [Ulas, M.] Firat Univ, Dept Physiol, Fac Med, TR-23119 Elazig, Turkey -- [Sandal, S. -- Tekin, S.] Inonu Univ, Fac Med, Dept Physiol, TR-44000 Malatya, Turkey, Turkoglu, Semra -- 0000-0001-7682-0513, and Parlak, Akif Evren -- 0000-0002-2579-9985

Subjects
Male, Cell Survival, Biological activity, Antineoplastic Agents, Saccharomyces cerevisiae, Vitamins, Triazoles, Kidney, Antioxidants, Rats, Mannich Bases, 1,2,4-triazole, Liver, Mannich bases, Malondialdehyde, MCF-7 Cells, Animals, Humans
Abstract

WOS: 000386768700009, PubMed ID: 27453272, In this study, the effects of Mannich bases containing bis-1,2,4-triazole on the levels of in vivo malondialdehyde (MDA) and antioxidant vitamins (A, E, C) were examined in serum, livers and kidneys of rats. DA and vitamin (A, E, C) levels were determined by high performance liquid chromatography (HPLC). Antioxidant effect was investigated by determining the MDA levels in Saccharomyces cerevisiae cells as in vitro. Furthermore, the antitumor effects of compounds were investigated against MCF-7 human breast cancer cells. Interrelations of results among control and compound groups were evaluated using SPSS statistical software package. As a result, some of the compounds showed effective biological activity when compared to control conditions. The test compounds used in this study may be effective for utilization in the selection and design of model compounds for further studies.

Published
2016

24. RESEARCH OF GENOTOXIC EFFECT OF OLIVE MILL WASTEWATER WITH ALLIUM TEST SYSTEM

Author

Koca, S., Turkoglu, S., Gencer, L., Ozdemir, M., and [Koca, S. -- Ozdemir, M.] Adnan Menderes Univ, Sci & Arts Fac, Dept Biol, Aydin, Turkey -- [Turkoglu, S. -- Gencer, L.] Cumhuriyet Univ, Fac Sci, Dept Biol, Sivas, Turkey

Subjects
olive mill wastewater, Allium cepa, chromosome aberrations, mitotic index
Abstract

WOS: 000381331000024, Wastewater of the olive oil factory or olive olive mill wastewater occurs at the time of olive oil production and shows an important environmental contaminating feature due to the organic substances inside them and the toxicities of these substances to various biological systems. The toxicity of olive mill wastewater stems from the phenolic compounds which are included in olive mill wastewater. In our study, genotoxic effects of the olive mill wastewater on the Allium cepa root tip meristem cells have been examined. The onions were rooted at 0.1, 0.3 and 0.5% concentrations of the olive mill wastewater. It was observed that concentrations decreased the mitotic index compared to the control and only the decrease at 0.5% group was statistically significant. In the study, the abnormalities such as anaphase bridge, laggard chromosome, C-metaphase, stickness, irregular distribution and polar deviation, etc. were observed. In the study done with 1, 3 and 5% concentrations of the olive olive mill wastewater, was concluded that root extension was too little and even 5% concentration showed a toxic effect.

Published
2016

28. Investigation of biological effects of some Mannich Bases containing Bis-1,2,4-Tr

Author

Parlak A.E., Celik S., Karatepe M., Turkoglu S., Alayunt N.O., Dastan S.D., Koparir M., and Uşak Üniversitesi

Subjects
1,2,4-triazole, Biological activity, Mannich bases
Abstract

PubMed ID: 27453272 In this study, the effects of Mannich bases containing bis-1,2,4-triazole on the levels of in vivo malondialdehyde (MDA) and antioxidant vitamins (A, E, C) were examined in serum, livers and kidneys of rats. DA and vitamin (A, E, C) levels were determined by high performance liquid chromatography (HPLC). Antioxidant effect was investigated by determining the MDA levels in Saccharomyces cerevisiae cells as in vitro. Furthermore, the antitumor effects of compounds were investigated against MCF-7 human breast cancer cells. Interrelations of results among control and compound groups were evaluated using SPSS statistical software package. As a result, some of the compounds showed effective biological activity when compared to control conditions. The test compounds used in this study may be effective for utilization in the selection and design of model compounds for further studies. © 2016 by the C.M.B. Association. All rights reserved.

Published
2016

29. Investigation of biological effects of some Mannich Bases containing Bis-1,2,4-Triazole

Author

Parlak, A. E., Celik, S., Karatepe, M., Turkoglu, S., Alayunt, N. O., Dastan, S. D., Koparir, M., and Uşak Üniversitesi

Subjects
Mannich bases, 1,2,4-triazole, Biological activity
Abstract

WOS: 000386768700009 PubMed ID: 27453272 In this study, the effects of Mannich bases containing bis-1,2,4-triazole on the levels of in vivo malondialdehyde (MDA) and antioxidant vitamins (A, E, C) were examined in serum, livers and kidneys of rats. DA and vitamin (A, E, C) levels were determined by high performance liquid chromatography (HPLC). Antioxidant effect was investigated by determining the MDA levels in Saccharomyces cerevisiae cells as in vitro. Furthermore, the antitumor effects of compounds were investigated against MCF-7 human breast cancer cells. Interrelations of results among control and compound groups were evaluated using SPSS statistical software package. As a result, some of the compounds showed effective biological activity when compared to control conditions. The test compounds used in this study may be effective for utilization in the selection and design of model compounds for further studies.

Published
2016

31. Acute Anterior Myocardial Infarction Accompanied by Acute Inferior Myocardial Infarction: A Very Rare Coronary Artery Anomaly

Author

Alsancak, Y., Sezenöz, B., Duran, M., Unlu, S., Turkoglu, S., and Yalcın, R.

Subjects
Article Subject
Abstract

Coronary artery anomalies are rare and mostly silent in clinical practice. First manifestation of this congenital abnormality can be devastating as syncope, acute coronary syndrome, and sudden cardiac death. Herein we report a case with coronary artery anomaly complicated with ST segment myocardial infarction in both inferior and anterior walls simultaneously diagnosed during primary percutaneous coronary intervention.

Published
2015
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32. Antioxidant properties of rubus discolor l. extracts and protective effects of its flower extract against hydrogen peroxide-induced oxidative stress in wistar rats [Rubus discolor L. ekstrelerinin antioksidan özellikleri ve çiçek ekstresinin hidrojen peroksit-nedenli oksidatif stres Oluşturulmuş wistar sıçanlarda koruyucu etkileri]

Author

Keser S., Celik S., Turkoglu S., Yilmaz Ö., Turkoglu I., and Uşak Üniversitesi

Subjects
Cholesterol, MDA, GSH, food and beverages, Rubus discolor, SOD, Hydrogen peroxide
Abstract

In the present study, in vitro antioxidant activities of ethanol and water extracts of Rubus discolor L. leaves, flower, unripe and ripe fruits were investigated. Additionally, the antioxidant and protective properties of R. discolor flower (RD) water extract on some important biochemical parameters against hydrogen peroxide (HP)-induced oxidative stress in rats were determined. The phytochemical profiles and antioxidant properties (scavenging against DPPH•, ABTS•+, H2O2, O2-, metal chelating, inhibition of lipid peroxidation and reducing power) of extracts were determined by spectrophotometric methods and HPLC. The antioxidant potential of RD flower extract supplementations were evaluated by measuring total protein, glutathione (GSH), malondialdehyde (MDA), vitamin A and E, cholesterol, glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) levels in various tissues. The flower extracts were the most active extracts for in vitro antioxidant assays. In HP administered groups, MDA level was increased, GSH and total protein levels were decreased. In RD treated group, these substances levels were protected. In RD plus HP treated group, SOD and GSH-Px levels were increased. These results show that RD flower extract have the protective effects against H2O2 via its free radical scavenging activity, and this extract affected the level of antioxidant enzymes, vitamin A and E, cholesterol, GSH, total protein and MDA. © 2015, Turkish Pharmacists Association. All rights reserved.

Published
2015

33. Investigation of anti-cholinesterase and anti-amyloidogenic activities of β-lactam antibiotics

Author

Özer Eda Özturan, Mirza Hasan Cenk, Tan Oya Ünsal, and Türkoğlu Suna

Subjects
β-lactam antibiotics, acetylcholinesterase, amyloid beta peptides, butyrylcholinesterase, molecular docking, β-laktam antibiyotik, amiloid beta peptit, asetilkolinesteraz, bütirilkolinesteraz, moleküler modelleme, Biochemistry, QD415-436
Abstract

Neuroinflammation is an important factor in the pathogenesis of neurodegenerative disesases. The following study aimed to clarify the effects of β-lactam antibiotics to the cholinergic system, on acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) activities, considering the structural differences of antibiotics, to evaluate the underlying mechanism of effects provided by protein-antibiotic interactions, and to clarify possible effects of the antibiotics on the aggregation of Aβ-peptides.

Published
2022
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36. Fatty acid composition of Gryllus campestris L. (Orthoptera: Gryllidae) during its various developmental stages

Author

Akpinar, MA, Akpinar, N, Gencer, L, Turkoglu, S, Akpinar, M.A., Department of Biology, Faculty of Science and Arts, Cumhuriyet University, 58140 Sivas, Turkey -- Akpinar, N., Department of Biology, Faculty of Science and Arts, Cumhuriyet University, 58140 Sivas, Turkey -- Gencer, L., Department of Biology, Faculty of Science and Arts, Cumhuriyet University, 58140 Sivas, Turkey -- Turkoglu, S., Department of Biology, Faculty of Science and Arts, Cumhuriyet University, 58140 Sivas, Turkey, and Cumhuriyet Univ, Fac Sci & Arts, Dept Biol, TR-58140 Sivas, Turkey

Subjects
Eggs, Gryllus campestris, food and beverages, lipids (amino acids, peptides, and proteins), Fatty acids, equipment and supplies, Developmental stages
Abstract

WOS: 000188054500007, The fatty acid composition of Gryllus campestris was analyzed by gas chromatography at successive stages during development and including own eggs. Qualitative analysis revealed the presence of 14 fatty acids (carbon chain length from C12 through C20) in addition to unidentified fatty acids during all stages. There were no differences between fatty acid profiles of eggs, all nymphs, male and female adults. The major components of total fatty acid composition were C16:0, C18:0, C18:1, C18:2 and C18:3. These fatty acids were found to comprise 88-92% of the total fatty acids in all nymphs, male and female adults. The content of C16:0, C18:0, C18:1 and C18:3 decreased in eggs and emerged nymph in contrast; the content of C16:1, C18:2 and C20 fatty acids increased. Certain C20 polyunsaturated fatty acids (PUFA) (C20:2, C20:3 and C20:4) were detected in the nymphs and adults. Decreases were observed in the contents of total saturated and total polyunsaturated fatty acids, but total monosaturated fatty acid content showed an increase as from the first nyrnph stage of both sexes. It is suggested that the fatty acids C16:0, C18:1, C18 and C20 PUAFs are necessary for normal development of G. campestris during their life stages.

Published
2003

37. Karyotype, C- and G-band Patterns and DNA content of Callimenus (=Bradyporus) macrogaster macrogaster

Author

Turkoglu S., Koca S., and Turkoglu, S., Celal Bayar University, Faculty of Science and Art, Department of Biology, Manisa, Turkey -- Koca, S., Cumhuriyet University, Faculty of Science and Art, Department of Biology, 58140, Sivas, Turkey

Subjects
C- and G- banding, Callimenus (=Bradyporus) macrogaster macrogaster, DNA content, Karyotype, Orthoptera, Cricket, Chromosomes
Abstract

Chromosomes and detailed karyotype information (the number, shape, relative length, arm ratio, centromeric index) of Callimenus (=Bradyporus) macrogaster macrogaster Lef. (Orthoptera: Tettigonioidea, Bradyporini) of Turkey belonging to the subfamily Bradyporinae are described. The diploid number of chromosomes was found to be 2n ?= 23, with 2 metacentric pairs, 2 submetacentric pairs, 6 acrocentric pairs. The X chromosome is metacentric. This species has a XX ?/X0 ? sex determining mechanism. The basic karyotype is complemented by a description of C- and G-banding patterns. The C-banding pattern in spermatogonial metaphase was characterized by the presence of paracentromeric C-bands in all chromosomes, and a distal C-band in chromosome 5. The G-banding pattern was complex. The 2C nuclear DNA content was found to be 10.26 ± 0.16 picograms by microspectrophotometry.

Published
2002

38. Determination of antioxidant capacities of phlomis pungens willd. var. hispida hub.-mor

Author

Serhat KESER, Turkoglu, S., Celik, S., Turkoglu, I., and Uşak Üniversitesi

Subjects
DPPH •, Phlomis pungens, food and beverages, ABTS • +, Antioxidant capacity, Superoxide radical
Abstract

The genus Phlomis L. belongs to the Lamiaceae family and encompasses 100 species native to Turkey, North Africa, Europe and Asia. It is a popular herbal tea enjoyed for its taste and aroma. Phlomis species are used to treat various conditions such as diabetes, gastric ulcer, hemorrhoids, inflammation and wounds. In this study, ethanol and water extracts were prepared from powdered P. pungens flowers and leaves. Antioxidant activities were measured by 2,2-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS • +) radical scavenging, 1,1- diphenyl-2-picryl-hydrazyl free radical (DPPH •) scavenging, superoxide anion (O2 •) radical scavenging, reducing activity and ferrous metal chelating activity assays. In conclusion, P. pungens flowers and leaves had effective ABTS • + and DPPH • radical scavenging, superoxide anion radical scavenging, reducing power and metal chelating activities when compared with BHA, BHT and a-tocopherol as reference antioxidants.

Published
2012

39. Antioxidant Properties of Wild Edible Mushroom Pleurotus eryngii Collected from Tunceli Province of Turkey

Author

Yildirim, N.C., Turkoglu, S., Yildirim, N., Ince, O.K. and Tunceli Meslek Yüksekokulu

Abstract

Antioxidants are our first line of defense against free radical damage, and are critical for maintaining health. The need for antioxidants becomes even more critical with increased exposure to free radicals. In the past few years there has been an increasing interest in determining relevant dietary sources of antioxidant phenolics. Mushrooms have been not only used as food materials with their unique flavor and texture, but also recognized as an important source of biologically active compound of medicinal value. In our study, to determine the antioxidant properties of the methanolic extracts of Pleurotus eryngii strains collected from different region of Tunceli, radical scavenging activity, total phenolic contents, reducing power, metal chelating activity and total antioxidant status (TAS) were analyzed. The analysis of phenolic compounds was performed by HPLC. In particular, the methanolic extract of P. eryngii collected from city center revealed the highest DPPH radical scavenging activity and reducing power, while the highest total phenolics and total antioxidant status was determined in P. eryngii collected from Pülümür. P. eryngii collected from Ovacık showed the highest chelating effects. Concentration of phenolic compounds found in three wild edible mushrooms. Kaempferol and catechin were not determined in musrooms species. The highest rutin levels were determined in ovacık. Resveratrol was determined only in Pulumur. The studied wild mushrooms might be beneficial to protect human body against oxidative damage.

Published
2012

40. Determination Of Antioxidant Properties Of Ethanol And Water Extracts Of Achillea Millefolium L. (Yarrow)

Author

Serhat KESER, Celik, S., Turkoglu, S., Yilmaz, Ö, and Turkoglu, I.

Abstract

Achillea millefolim L. is a member of the Asteraceae family that is commonly referred to as 'yarrow' and has been used in folk medicine against several disturbances including skin inflammations, spasmodic and gastrointestinal disorders, as well as hepato-biliary complaints. Ethanol and water extracts were prepared from powdered A. millefoliun flowers, leaves and seeds. In this study, antioxidant properties were studied by 2,2-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS(center dot+)) radical scavenging, 1,1-diphenyl-2-picryl-hydrazyl free radical (DPPH(center dot)) scavenging, superoxide anion (O(2)(center dot-)) radical scavenging, reducing activity and ferrous metal chelating activity assays. In conclusion, A. millefolium flowers, leaves and seeds had effective ABTS(center dot+) and DPPH(center dot) radical scavenging, superoxide anion radical scavenging, reducing power and metal chelating activities. Additionally, these various antioxidant activities were compared with BHA, BHT and alpha-tocopherol as reference antioxidants.

Published
2011

47. Head-to-head comparison of two different low-molecular-weight heparins in acute coronary syndrome - A single center experience

Author

Yalcin, R, Ozdemir, M, Cemri, M, Cengel, A, Dortlemez, O, Dortlemez, H, Turkoglu, S, Erdem, G, Timurkaynak, T, and Boyaci, B

Abstract

Low-molecular-weight hepatitis (LMWH) of different types have yielded different results when used in the setting of unstable angina (UA) or non Q-wave myocardial infarction (NQMI). We compared the safety and therapeutic efficacy of two different LMWHs, namely dalteparin (Dalt.) and enoxaparin (Enox.), in the acute phase (first 5 days) of UA or NQMI.

Published
2002

50. Secondary glaucoma after congenital cataract surgery

Author

Ariturk, N, Oge, I, Mohajery, F, Erkan, D, Turkoglu, S, and Ondokuz Mayıs Üniversitesi

Subjects
congenital cataract surgery, genetic structures, congenital cataract, sense organs, eye diseases
Abstract

WOS: 000083301500008 PubMed: 10548463 Purpose: Glaucoma has been recognized as an infrequent but serious complication following surgery for congenital cataract in childhood. We conducted a retrospective review of patients in whom glaucoma had developed after surgery for congenital cataract. Methods: We reviewed the records of 87 eyes of 53 patients on whom cataract surgery had been performed between February 1982 and March 1995 at Ondokuz Mayis University Hospital, Samsun. Results: The average postoperative follow-up is 4.5 years (range 1 to 12 years). We identified open angle glaucoma (OAG) in 17 eyes, chronic angle closure glaucoma (ACG) in six eyes, and acute angle closure glaucoma (AACG) in two eyes. The average time between cataract surgery and the diagnosis of glaucoma was 6.08 years (range one week to 10 years). The mean time to diagnosis of glaucoma was 4.7 years (range 4 months to 10 years) for OAG, 4.3 years (range 1 to 8 years) for ACG and, for AACG, 7 days and 10 months following surgery. Medication alone was successful in intraocular pressure control in 17 of 25 eyes (

Published
1998

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