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Background: Fibromyalgia (FM) is a common soft tissue rheumatic disease. There is no established treatment plan for FM. Current treatments primarily focus on controlling symptoms and improving the quality of life. The aim of our study was to determine how connective tissue massage (CTM) and kinesiotaping (KT) affect pain and depression in patients with fibromyalgia, and to compare their effects on quality of life., Methods: Thirty-four patients diagnosed with fibromyalgia were included. Participants divided into two groups. Group 1: CTM (n = 17, mean age = 35.47 ± 6.84 years), Group 2: KT (n = 17, mean age = 34.00 ± 5.46 years). This study was initiated by obtaining sociodemographic information. Pain (Visual Analogue Scale (VAS)), pain characteristics (McGill Pain Questionnaire), disease impact on patients (Fibromyalgia Impact Questionnaire (FIQ)), depression (Beck's Depression Inventory (BDI)), and quality of life (Short Form-36 (SF-36)) were evaluated. All participants received electrotherapy (TENS and infrared treatment) for 25 min, 5 days a week for 4 weeks. CTM was applied 3 days a week, KT was applied 2 days a week for 4 weeks., Results: A significant improvement with very large effect size was found in VAS, McGill, FIQ, BDI, and SF-36 variables in both groups (p < 0.05). The change after 4 weeks of treatment was similar between groups in terms of all parameters (p > 0.05)., Conclusion: Both CTM and KT improved pain, disease effects depression, and quality of life. These two interventions, which are not superior, can be added to the treatment program for patients with fibromyalgia., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We declare that we have no competing financial interests or personal relationships that could influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)