15 results on '"Tuul, M."'
Search Results
2. Stereometrical research studies on tissues and cells of parenchymal organs of Mongolians in normal and pathological conditions
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Sukhbaatar, Ts., Tuul, M., Enkhee, Sh., Tsogtbayar, D., Lkhagva, L., Kim, Sun I., editor, Suh, Tae Suk, editor, Magjarevic, R., editor, and Nagel, J. H., editor
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- 2007
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3. The x-ray structure and osteostereometric study the sponge bone of Mongols
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Jargalbat, P., Batdemberel, G., Ajnai, L., Tuul, M., Chadraabal, Sh., Batbayar, Kh., Kim, Sun I., editor, Suh, Tae Suk, editor, Magjarevic, R., editor, and Nagel, J. H., editor
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- 2007
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4. Evaluation of existing resources (study/analysis)
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García-Peñalvo, Francisco J., Hughes, J., Rees, A., Jormanainen, I., Toivonen, T., Reimann, D., Tuul, M., and Virnes, M.
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33 Ciencias tecnológicas ,Coding ,Pensamiento computacional ,Computational thinking ,Codificación ,TACCLE3 ,Resources ,Recursos ,Computational Thinking ,TACCLE 3 - Abstract
Within TACCLE 3 – Coding European Union Erasmus+ KA2 Programme project, a review and evaluation of a set of resources that can contribute to teaching programming to younger children has made. This document represents the TACCLE 3 O4 deliverable entitled “Evaluation of existing resources (study/analysis)”.
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- 2016
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5. An overview of the most relevant literature on coding and computational thinking with emphasis on the relevant issues for teachers
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García-Peñalvo, Francisco J., Reimann, Daniela, Tuul, M., Rees, A., and Jormanainen, I.
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Literature review ,33 Ciencias tecnológicas ,Coding ,Computational Thinking ,Literature Review ,TACCLE 3 ,Pensamiento computacional ,Revisión de literatura ,Computational thinking ,Codificación ,TACCLE3 - Abstract
The rationale for this literature review is to take the main areas of debate surrounding the teaching of coding to primary aged children and examine the polemic and the different positions that writers and practitioners are taking on these issues. This is intended to be a literature review useful to practitioners rather than academics. In that vein, in addition to published peer referenced journal articles we have decided to make maximum use of blog posts and opinions on social media for our source material as we believe that the most informed debate on kids coding is not actually going on in academic journals!
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- 2016
6. Stereometrical research studies on tissues and cells of parenchymal organs of Mongolians in normal and pathological conditions
- Author
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Sukhbaatar, Ts., primary, Tuul, M., additional, Enkhee, Sh., additional, Tsogtbayar, D., additional, and Lkhagva, L., additional
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7. The x-ray structure and osteostereometric study the sponge bone of Mongols
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Jargalbat, P., primary, Batdemberel, G., additional, Ajnai, L., additional, Tuul, M., additional, Chadraabal, Sh., additional, and Batbayar, Kh., additional
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8. Stereometrical research studies on tissues and cells of parenchymal organs of Mongolians in normal and pathological conditions.
- Author
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Kim, Sun I., Suh, Tae Suk, Magjarevic, R., Nagel, J. H., Sukhbaatar, Ts., Tuul, M., Enkhee, Sh., Tsogtbayar, D., and Lkhagva, L.
- Abstract
Currently studies on microstructures of human internal organs and their morphometry are conducted with the use of high level methodological tools such as stereometry, ultrastereometry and mathematic models of their pathological changes have been developed for accurate diagnosing. [ABSTRACT FROM AUTHOR]
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- 2007
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9. The x-ray structure and osteostereometric study the sponge bone of Mongols.
- Author
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Kim, Sun I., Suh, Tae Suk, Magjarevic, R., Nagel, J. H., Jargalbat, P., Batdemberel, G., Ajnai, L., Tuul, M., Chadraabal, Sh., and Batbayar, Kh.
- Abstract
An X-ray diffraction study of crystal structure of bone apatite of Mongols and its changes and dependence on human ages has been carried out. The FullProt program based on the Rietveld method was used. In apart from separating proteins molecule off each sample was heated at 800°C during 30 minutes. Not depending on this heat treatment of all the samples consist only the fluoric apatite (Ca5(PO4)F) phase. As a result of refinement of the diffractograms it was established variation of parameters of bone apatite crystal structures (the unite cell constants, the coordinates of atoms, Debye-Waller heat factors of atoms, the atom contents and the unite cell volume) on different ways. It is also evident that the Ca1 atomic content increases with aging. This study has adjusted with research result that bone cell decreases and osteoseptum adjacent when people to get on in years. The bone main elements content changing is a very important factor to determine defect relating formation and function and aging process. Crystal structure of the bone apatite and osteostereometric analysis leads to a hypothesis Mongolian human aging process and specially bone structure changing is over-due. [ABSTRACT FROM AUTHOR]
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- 2007
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10. Impact of Back-to-Base Normothermic Machine Perfusion on Complications and Costs: A Multicenter, Real-World Risk-Matched Analysis.
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Wehrle CJ, Zhang M, Khalil M, Pita A, Modaresi Esfeh J, Diago-Uso T, Kim J, Aucejo F, Kwon DCH, Ali K, Cazzaniga B, Miyazaki Y, Liu Q, Fares S, Hong H, Tuul M, Jiao C, Sun K, Fairchild RL, Quintini C, Fujiki M, Pinna AD, Miller C, Hashimoto K, and Schlegel A
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- Humans, Male, Female, Middle Aged, Retrospective Studies, Adult, Aged, Graft Survival, Liver Transplantation economics, Perfusion methods, Organ Preservation methods, Organ Preservation economics, Postoperative Complications economics, Postoperative Complications epidemiology
- Abstract
Objective: Assess cost and complication outcomes after liver transplantation (LT) using normothermic machine perfusion (NMP)., Background: End-ischemic NMP is often used to aid logistics, yet its impact on outcomes after LT remains unclear, as does its true impact on costs associated with transplantation., Methods: Deceased donor liver recipients at 2 centers (January 1, 2019, to June 30, 2023) were included. Retransplants, splits, and combined grafts were excluded. End-ischemic NMP (OrganOx-Metra) was implemented in October 2022 for extended-criteria donation after brain death (DBDs), all donations after circulatory deaths (DCDs), and logistics. NMP cases were matched 1:2 with static cold storage controls (SCS) using the Balance-of-Risk [donation after brain death (DBD)-grafts] and UK-DCD Score (DCD-grafts)., Results: Overall, 803 transplantations were included, 174 (21.7%) receiving NMP. Matching was achieved between 118 NMP-DBDs with 236 SCS; and 37 NMP-DCD with 74 corresponding SCS. For both graft types, median inpatient comprehensive complications index values were comparable between groups. DCD-NMP grafts experienced reduced cumulative 90-day comprehensive complications index (27.6 vs 41.9, P =0.028). NMP also reduced the need for early relaparotomy and renal replacement therapy, with subsequently less frequent major complications (Clavien-Dindo ≥IVa). This effect was more pronounced in DCD transplants. NMP had no protective effect on early biliary complications. Organ acquisition/preservation costs were higher with NMP, yet NMP-treated grafts had lower 90-day pretransplant costs in the context of shorter waiting list times. Overall costs were comparable for both cohorts., Conclusions: This is the first risk-adjusted outcome and cost analysis comparing NMP and SCS. In addition to logistical benefits, NMP was associated with a reduction in relaparotomy and bleeding in DBD grafts, and overall complications and post-LT renal replacement for DCDs. While organ acquisition/preservation was more costly with NMP, overall 90-day health care costs-per-transplantation were comparable., Competing Interests: The authors report no conflicts of interest., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2024
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11. The impact of normothermic machine perfusion and acuity circles on waitlist time, mortality, and cost in liver transplantation: A multicenter experience.
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Wehrle CJ, Hong H, Gross A, Liu Q, Ali K, Cazzaniga B, Miyazaki Y, Tuul M, Modaresi Esfeh J, Khalil M, Pita A, Fernandes E, Kim J, Diago-Uso T, Aucejo F, Kwon DCH, Fujiki M, Quintini C, Schlegel A, Pinna A, Miller C, and Hashimoto K
- Abstract
Ex situ normothermic machine perfusion (NMP) helps increase the use of extended criteria donor livers. However, the impact of an NMP program on waitlist times and mortality has not been evaluated. Adult patients listed for liver transplant (LT) at 2 academic centers from January 1, 2015, to September 1, 2023, were included (n=2773) to allow all patients ≥6 months follow-up from listing. Routine NMP was implemented on October 14, 2022. Waitlist outcomes were compared from pre-NMP pre-acuity circles (n=1460), pre-NMP with acuity circles (n=842), and with NMP (n=381). Median waitlist time was 79 days (IQR: 20-232 d) at baseline, 49 days (7-182) with acuity circles, and 14 days (5-56) with NMP ( p <0.001). The rate of transplant-per-100-person-years improved from 61-per-100-person-years to 99-per-100-person-years with acuity circles and 194-per-100-person-years with NMP ( p <0.001). Crude mortality without transplant decreased from 18.3% (n=268/1460) to 13.3% (n=112/843), to 6.3% (n=24/381) ( p <0.001) with NMP. The incidence of mortality without LT was 15-per-100-person-years before acuity circles, 19-per-100 with acuity circles, and 9-per-100-person-years after NMP ( p <0.001). Median Model for End-Stage Liver Disease at LT was lowest with NMP, but Model for End-Stage Liver Disease at listing was highest in this era ( p <0.0001). The median donor risk index of transplanted livers at baseline was 1.54 (1.27-1.82), 1.66 (1.42-2.16) with acuity circles, and 2.06 (1.63-2.46) with NMP ( p <0.001). Six-month post-LT survival was not different between eras ( p =0.322). The total cost of health care while waitlisted was lowest in the NMP era ($53,683 vs. $32,687 vs. $23,688, p <0.001); cost-per-day did not differ between eras ( p =0.152). The implementation of a routine NMP program was associated with reduced waitlist time and mortality without compromising short-term survival after liver transplant despite increased use of riskier grafts. Routine NMP use enables better waitlist management with reduced health care costs., (Copyright © 2024 American Association for the Study of Liver Diseases.)
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- 2024
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12. Left Lobe First With Purely Laparoscopic Approach: A Novel Strategy to Maximize Donor Safety in Adult Living Donor Liver Transplantation.
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Fujiki M, Pita A, Kusakabe J, Sasaki K, You T, Tuul M, Aucejo FN, Quintini C, Eghtesad B, Pinna A, Miller C, Hashimoto K, and Kwon CHD
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- Adult, Humans, Living Donors, Liver surgery, Hepatectomy methods, Bilirubin, Treatment Outcome, Liver Transplantation methods, Laparoscopy
- Abstract
Objective: Evaluate outcome of left-lobe graft (LLG) first combined with purely laparoscopic donor hemihepatectomy (PLDH) as a strategy to minimize donor risk., Background: An LLG first approach and a PLDH are 2 methods used to reduce surgical stress for donors in adult living donor liver transplantation (LDLT). But the risk associated with application LLG first combined with PLDH is not known., Methods: From 2012 to 2023, 186 adult LDLTs were performed with hemiliver grafts, procured by open surgery in 95 and PLDH in 91 cases. LLGs were considered first when graft-to-recipient weight ratio ≥0.6%. Following a 4-month adoption process, all donor hepatectomies, since December 2019, were performed laparoscopically., Results: There was one intraoperative conversion to open (1%). Mean operative times were similar in laparoscopic and open cases (366 vs 371 minutes). PLDH provided shorter hospital stays, lower blood loss, and lower peak aspartate aminotransferase. Peak bilirubin was lower in LLG donors compared with right-lobe graft donors (1.4 vs 2.4 mg/dL, P < 0.01), and PLDH further improved the bilirubin levels in LLG donors (1.2 vs 1.6 mg/dL, P < 0.01). PLDH also afforded a low rate of early complications (Clavien-Dindo grade ≥ II, 8% vs 22%, P = 0.007) and late complications, including incisional hernia (0% vs 13.7%, P < 0.001), compared with open cases. LLG was more likely to have a single duct than a right-lobe graft (89% vs 60%, P < 0.01). Importantly, with the aggressive use of LLG in 47% of adult LDLT, favorable graft survival was achieved without any differences between the type of graft and surgical approach., Conclusions: The LLG first with PLDH approach minimizes surgical stress for donors in adult LDLT without compromising recipient outcomes. This strategy can lighten the burden for living donors, which could help expand the donor pool., Competing Interests: C.H.D.K. has consulted for, received compensation for serving as a fiduciary from, or received royalties from the following companies, Medtronic plc, Integra Lifesciences Corporation, and Fujifilm. The remaining authors report no conflicts of interest., (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2023
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13. Prognostic relevance of KRAS and BRAF mutations in Japanese patients with colorectal cancer.
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Nakanishi R, Harada J, Tuul M, Zhao Y, Ando K, Saeki H, Oki E, Ohga T, Kitao H, Kakeji Y, and Maehara Y
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- Aged, Aged, 80 and over, Antibodies, Monoclonal therapeutic use, Base Sequence, Biomarkers, Tumor genetics, Colorectal Neoplasms pathology, ErbB Receptors genetics, ErbB Receptors immunology, Female, Humans, Male, Middle Aged, Mutation, Neoplasm Recurrence, Local pathology, Prognosis, Proportional Hazards Models, Proto-Oncogene Proteins p21(ras), Retrospective Studies, Colorectal Neoplasms genetics, Neoplasm Recurrence, Local genetics, Proto-Oncogene Proteins genetics, Proto-Oncogene Proteins B-raf genetics, ras Proteins genetics
- Abstract
Background: Mutations of the KRAS or BRAF genes are now recognized as prognostic markers for colorectal cancer (CRC). They are also important predictive markers for resistance to the monoclonal antibodies that target the epidermal growth factor receptor., Methods: In this retrospective study, KRAS and BRAF mutations were analyzed using a direct sequence method in 254 Japanese CRC patients, and the associations between KRAS or BRAF mutations and clinicopathological characteristics or outcome were evaluated., Results: KRAS and BRAF mutations were detected in 33.5 and 6.7 % of all patients, respectively. Consistent with previous reports, BRAF mutations were significantly correlated with the anatomical site of the tumor (P < 0.001), tumor grade (P = 0.001) and high frequency of microsatellite instability (P < 0.001). BRAF mutations were correlated with poor overall survival in the full patient cohort (P = 0.009). KRAS mutations were significantly correlated with poor recurrence-free survival (P = 0.03), particularly in patients with stage II CRC (P = 0.007). Cox regression analysis showed that KRAS mutations were a negative predictor of recurrence-free survival in patients with stage II CRC., Conclusion: KRAS mutation status could be a novel biomarker for predicting disease recurrence in Japanese patients with stage II CRC.
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- 2013
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14. Rad9, Rad17, TopBP1 and claspin play essential roles in heat-induced activation of ATR kinase and heat tolerance.
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Tuul M, Kitao H, Iimori M, Matsuoka K, Kiyonari S, Saeki H, Oki E, Morita M, and Maehara Y
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- Animals, Ataxia Telangiectasia Mutated Proteins, Caffeine pharmacology, Cell Cycle Proteins deficiency, Cell Line, Tumor, Checkpoint Kinase 1, Chickens, DNA Damage, Fluorescent Antibody Technique, Gene Expression Regulation physiology, HeLa Cells, Hot Temperature, Humans, Phosphorylation drug effects, Protein Kinases metabolism, RNA Interference, RNA, Small Interfering, Acclimatization drug effects, Adaptor Proteins, Signal Transducing pharmacology, Carrier Proteins pharmacology, Cell Cycle Proteins metabolism, Cell Cycle Proteins pharmacology, DNA-Binding Proteins pharmacology, Enzyme Activation drug effects, Nuclear Proteins pharmacology, Protein Serine-Threonine Kinases metabolism
- Abstract
Hyperthermia is widely used to treat patients with cancer, especially in combination with other treatments such as radiation therapy. Heat treatment per se activates DNA damage responses mediated by the ATR-Chk1 and ATM-Chk2 pathways but it is not fully understood how these DNA damage responses are activated and affect heat tolerance. By performing a genetic analysis of human HeLa cells and chicken B lymphoma DT40 cells, we found that heat-induced Chk1 Ser345 phosphorylation by ATR was largely dependent on Rad9, Rad17, TopBP1 and Claspin. Activation of the ATR-Chk1 pathway by heat, however, was not associated with FancD2 monoubiquitination or RPA32 phosphorylation, which are known as downstream events of ATR kinase activation when replication forks are stalled. Downregulation of ATR, Rad9, Rad17, TopBP1 or Claspin drastically reduced clonogenic cell viability upon hyperthermia, while gene knockout or inhibition of ATM kinase reduced clonogenic viability only modestly. Suppression of the ATR-Chk1 pathway activation enhanced heat-induced phosphorylation of Chk2 Thr68 and simultaneous inhibition of ATR and ATM kinases rendered severe heat cytotoxicity. These data indicate that essential factors for activation of the ATR-Chk1 pathway at stalled replication forks are also required for heat-induced activation of ATR kinase, which predominantly contributes to heat tolerance in a non-overlapping manner with ATM kinase.
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- 2013
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15. ATR-Chk1 signaling pathway and homologous recombinational repair protect cells from 5-fluorouracil cytotoxicity.
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Fujinaka Y, Matsuoka K, Iimori M, Tuul M, Sakasai R, Yoshinaga K, Saeki H, Morita M, Kakeji Y, Gillespie DA, Yamamoto K, Takata M, Kitao H, and Maehara Y
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- Animals, Apoptosis drug effects, Cell Cycle Proteins metabolism, Cell Death drug effects, Cell Line, Tumor, Cell Nucleus drug effects, Checkpoint Kinase 1, Chickens, DNA Breaks, Double-Stranded drug effects, Fanconi Anemia Complementation Group D2 Protein metabolism, Histones metabolism, Lymphoma, B-Cell enzymology, Lymphoma, B-Cell pathology, Mutation genetics, Phosphorylation drug effects, Staurosporine analogs & derivatives, Staurosporine pharmacology, Time Factors, Cell Nucleus metabolism, Cytoprotection drug effects, Fluorouracil pharmacology, Protein Kinases metabolism, Protein Serine-Threonine Kinases metabolism, Recombinational DNA Repair drug effects, Signal Transduction drug effects
- Abstract
5-Fluorouracil (5-FU) has long been a mainstay antimetabolite chemotherapeutic drug for the treatment of major solid tumors, particularly colorectal cancer. 5-FU is processed intracellularly to yield active metabolites that compromise RNA and DNA metabolism. However, the mechanisms responsible for its cytotoxicity are not fully understood. From the phenotypic analysis of mutant chicken B lymphoma DT40 cells, we found that homologous recombinational repair (HRR), involving Rad54 and BRCA2, and the ATR-Chk1 signaling pathway, involving Rad9 and Rad17, significantly contribute to 5-FU tolerance. 5-FU induced γH2AX nuclear foci, which were colocalized with the key HRR factor Rad51, but not with DNA double-strand breaks (DSBs), in a dose-dependent manner as cells accumulated in the S phase. Inhibition of Chk1 kinase by UCN-01 increased 5-FU-induced γH2AX and enhanced 5-FU cytotoxicity not only in wild-type cells but also in Rad54- or BRCA2-deficient cells, suggesting that HRR and Chk1 kinase have non-overlapping roles in 5-FU tolerance. 5-FU-induced Chk1 phosphorylation was significantly impaired in Rad9- or Rad17-deficient cells, and severe γH2AX nuclear foci and DSBs were formed, which was followed by apoptosis. Finally, inhibition of Chk1 kinase by UCN-01 increased 5-FU-induced γH2AX nuclear foci and enhanced 5-FU cytotoxicity in Rad9- or Rad17-deficient cells. These results suggest that Rad9- and Rad17-independent activation of the ATR-Chk1 signaling pathway also significantly contributes to 5-FU tolerance., (Copyright © 2011 Elsevier B.V. All rights reserved.)
- Published
- 2012
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