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Quercetin is a polyphenolic bioactive compound highly enriched in dietary fruits, vegetables, nuts, and berries. Quercetin and its derivatives like rutin and hyperoside are known for their beneficial effects in various neurological conditions including epilepsy. The clinical studies of quercetin and its derivatives in relation to epilepsy are limited. This review provides the evidence of most recent knowledge of anticonvulsant properties of quercetin and its derivatives on preclinical studies. Additionally, the studies demonstrating antiseizure potential of various plants extracts enriched with quercetin and its derivatives has been included in this review. Herein, we have also discussed neuroprotective effect of these bioactive compound and presented underlying mechanisms responsible for anticonvulsant properties in brief. Finally, limitations of quercetin and its derivatives as antiseizure compounds as well as possible strategies to enhance efficacy have also been discussed. [ABSTRACT FROM AUTHOR]

Background: About 67,000 women in India die every year (MoHFW, 2011), due to pregnancy related complications. Similarly, every year more than 13 lacs infants die, within 1 year of the birth and out of these approximately 9 lacs i.e. 2/3rd of the infant deaths take place within the first four weeks of life (1).Out of these, approximately 7 lacs i.e. 75% of the deaths take place within a week of the birth and a majority of these occur in the first two days after birth (1). In view of the difficulty being faced by the pregnant women and parents of sick new-born (MoHFW,2011), along with high out-of-pocket expenses incurred by them on delivery and treatment of sick new-born, Ministry of Health and Family Welfare has taken a major initiative, to provide completely free and cashless services to pregnant women including normal deliveries and caesarean operations and sick new born (up to 30 days after birth) in Government health institutions in both rural & urban areas. Material & Methods: In this community based descriptive cross-sectional study, data was collected from 100 mothers, who had delivered in last one year at District Hospital Maternal Wing situated at Morar Block of Gwalior District M.P and MO, ANM's, ASHA's, using Semi structured close ended Interview schedule and an open ended questionnaire respectively. Data were compared by using SPSS (ver. 22.0) Result: Expenses were divided under two heads, medical and non-medical. 15% of the total beneficiaries incurred the medical expenses in the form of medicines, diagnostics etc. and almost 99% of all the respondents incurred the non-medical expenses in the form of transport, food etc. Conclusion: Based on the outcome of the study the overall impression was that 59% of the beneficiaries were not aware of the JSSK scheme. Only during pregnancies through the initiatives of the ASHAs the beneficiaries came to know about the free entitlements of the scheme. There was unavailability of ambulance when required and delay in the services. [ABSTRACT FROM AUTHOR]

In this study, quantification of nitrophenol (NP), chlorophenol (CP), and hexachlorocyclohexane (HCH) compounds in agricultural soils in the vicinity of the industrial region in northern Uttar Pradesh, India was carried out for the assessment of human health hazard. The concentration of ∑NP, ∑CP, and ∑HCH compounds ranged 0.33–3.64 mg kg−1, 0.06–3.18 μg kg−1, and 1.23–17.24 mg kg−1, respectively, and were within the soil quality guidelines for the protection of human and environment health. Human health hazard index and cancer risk, on the basis of average daily intake of these compounds through soil for human adults and children, was lower than the acceptable limit. This study suggested low health hazard and risk due to phenolic and HCH compounds to human population. [ABSTRACT FROM PUBLISHER]

Competing Interests: None of the authors have competing interests. The views expressed in this article are those of the authors and do not necessarily reflect the positions of their institution or their other funders.