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Your search keyword '"Tzeng, Tsai‐Yu"' showing total 32 results
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32 results on '"Tzeng, Tsai‐Yu"'

2. Supplemental Table S3 from H3K9 Histone Methyltransferase, KMT1E/SETDB1, Cooperates with the SMAD2/3 Pathway to Suppress Lung Cancer Metastasis

Author

Wu, Pei-Chun, primary, Lu, Jeng-Wei, primary, Yang, Jer-Yen, primary, Lin, I-Hsuan, primary, Ou, Da-Liang, primary, Lin, Yu-Hsiang, primary, Chou, Kuan-Hsien, primary, Huang, Wen-Feng, primary, Wang, Wan-Ping, primary, Huang, Yih-Leh, primary, Hsu, Chiun, primary, Lin, Liang-In, primary, Lin, Yueh-Min, primary, Shen, C.-K. James, primary, and Tzeng, Tsai-Yu, primary

Published
2023
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3. Supplemental Figure S6 from H3K9 Histone Methyltransferase, KMT1E/SETDB1, Cooperates with the SMAD2/3 Pathway to Suppress Lung Cancer Metastasis

Author

Wu, Pei-Chun, primary, Lu, Jeng-Wei, primary, Yang, Jer-Yen, primary, Lin, I-Hsuan, primary, Ou, Da-Liang, primary, Lin, Yu-Hsiang, primary, Chou, Kuan-Hsien, primary, Huang, Wen-Feng, primary, Wang, Wan-Ping, primary, Huang, Yih-Leh, primary, Hsu, Chiun, primary, Lin, Liang-In, primary, Lin, Yueh-Min, primary, Shen, C.-K. James, primary, and Tzeng, Tsai-Yu, primary

Published
2023
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4. Supplemental Materials and Methods from H3K9 Histone Methyltransferase, KMT1E/SETDB1, Cooperates with the SMAD2/3 Pathway to Suppress Lung Cancer Metastasis

Author

Wu, Pei-Chun, primary, Lu, Jeng-Wei, primary, Yang, Jer-Yen, primary, Lin, I-Hsuan, primary, Ou, Da-Liang, primary, Lin, Yu-Hsiang, primary, Chou, Kuan-Hsien, primary, Huang, Wen-Feng, primary, Wang, Wan-Ping, primary, Huang, Yih-Leh, primary, Hsu, Chiun, primary, Lin, Liang-In, primary, Lin, Yueh-Min, primary, Shen, C.-K. James, primary, and Tzeng, Tsai-Yu, primary

Published
2023
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5. Data from H3K9 Histone Methyltransferase, KMT1E/SETDB1, Cooperates with the SMAD2/3 Pathway to Suppress Lung Cancer Metastasis

Author

Wu, Pei-Chun, primary, Lu, Jeng-Wei, primary, Yang, Jer-Yen, primary, Lin, I-Hsuan, primary, Ou, Da-Liang, primary, Lin, Yu-Hsiang, primary, Chou, Kuan-Hsien, primary, Huang, Wen-Feng, primary, Wang, Wan-Ping, primary, Huang, Yih-Leh, primary, Hsu, Chiun, primary, Lin, Liang-In, primary, Lin, Yueh-Min, primary, Shen, C.-K. James, primary, and Tzeng, Tsai-Yu, primary

Published
2023
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15. Muscle atrophy‐related myotube‐derived exosomal microRNA in neuronal dysfunction: Targeting both coding and long noncoding RNAs

Author

Yang, Chia‐Pei, primary, Yang, Wan‐Shan, additional, Wong, Yu‐Hui, additional, Wang, Kai‐Hsuan, additional, Teng, Yuan‐Chi, additional, Chang, Ming‐Hsuan, additional, Liao, Ko‐Hsun, additional, Nian, Fang‐Shin, additional, Chao, Chuan‐Chuan, additional, Tsai, Jin‐Wu, additional, Hwang, Wei‐Lun, additional, Lin, Ming‐Wei, additional, Tzeng, Tsai‐Yu, additional, Wang, Pei‐Ning, additional, Campbell, Mel, additional, Chen, Liang‐Kung, additional, Tsai, Ting‐Fen, additional, Chang, Pei‐Ching, additional, and Kung, Hsing‐Jien, additional

Published
2020
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18. Gene-editing by CRISPR–Cas9 in combination with anthracycline therapy viatumor microenvironment-switchable, EGFR-targeted, and nucleus-directed nanoparticles for head and neck cancer suppressionElectronic supplementary information (ESI) available. See DOI: 10.1039/d1nh00254f

Author

Wang, Chen-Shen, Chang, Chih-Hsien, Tzeng, Tsai-Yu, Lin, Anya Maan-Yuh, and Lo, Yu-Li

Abstract

Head and neck cancer (HNC) has a high incidence and a poor prognosis. Epirubicin, a topoisomerase inhibitor, is a potential anthracycline chemotherapeutic for HNC treatment. HuR (ELAVL1), an RNA-binding protein, plays a critical role in promoting tumor survival, invasion, and resistance. HuR knockout viaCRISPR/Cas9 (HuR CRISPR) is a possible strategy for the simultaneous modulation of the various pathways of tumor progression. Multifunctional nanoparticles modified with pH-sensitive epidermal growth factor receptor (EGFR)-targeting and nucleus-directed peptides were designed for the efficient delivery of HuR CRISPR and epirubicin to human tongue squamous carcinoma SAS cells and SAS tumor-bearing mice. The pH-sensitive nanoparticles responded to the acidic pH value as a switch to expose the targeting peptides. The cellular uptake and transfection efficiency of these nanoparticles in SAS cells increased viaEGFR targeting, ligand-mediated endocytosis, and endosomal escape. These nanoparticles showed low cytotoxicity towards normal oral keratinocyte NOK cells. CRISPR/Cas9 was transported into the nucleus viathe nuclear directing peptide and successfully knocked out HuR to suppress proliferation, metastasis, and resistance in SAS cells. The multiple inhibition of EGFR/β-catenin/epithelial–mesenchymal transition pathways was mediated through modulating the EGFR/PI3K/mTOR/AKT axis. The co-treatment of epirubicin and HuR CRISPR in SAS cells further facilitated apoptosis/necroptosis/autophagy and caused cancer cell death. In combination with HuR CRISPR nanoparticles, the efficacy and safety of epirubicin nanoparticles against cancer in SAS tumor-bearing mice improved significantly. Collectively, these nanoparticles showed a tumor pH response, active EGFR targeting, and nuclear localization and thus offered a combinatorial spatiotemporal platform for chemotherapy and the CRISPR/Cas gene-editing system.

Published
2021
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24. H3K9 Histone Methyltransferase, KMT1E/SETDB1, Cooperates with the SMAD2/3 Pathway to Suppress Lung Cancer Metastasis

Author

Wu, Pei-Chun, primary, Lu, Jeng-Wei, additional, Yang, Jer-Yen, additional, Lin, I-Hsuan, additional, Ou, Da-Liang, additional, Lin, Yu-Hsiang, additional, Chou, Kuan-Hsien, additional, Huang, Wen-Feng, additional, Wang, Wan-Ping, additional, Huang, Yih-Leh, additional, Hsu, Chiun, additional, Lin, Liang-In, additional, Lin, Yueh-Min, additional, Shen, C.-K. James, additional, and Tzeng, Tsai-Yu, additional

Published
2014
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25. Two Lily SEPALLATA-Like Genes Cause Different Effects on Floral Formation and Floral Transition in Arabidopsis1

Author

Tzeng, Tsai-Yu, Hsiao, Chih-Chi, Chi, Pei-Ju, and Yang, Chang-Hsien

Subjects
Homeodomain Proteins, Models, Genetic, Sequence Homology, Amino Acid, Arabidopsis Proteins, fungi, Molecular Sequence Data, Arabidopsis, food and beverages, Gene Expression Regulation, Developmental, MADS Domain Proteins, Flowers, Plants, Genetically Modified, Gene Expression Regulation, Plant, Amino Acid Sequence, Lilium, Phylogeny, Research Article, Plant Proteins, Transcription Factors
Abstract

Two AGL2-like MADS-box genes, Lily MADS Box Gene (LMADS) 3 and LMADS4, with extensive homology of LMADS3 to the Arabidopsis SEPALLATA3 were characterized from the lily (Lilium longiflorum). Both LMADS3 and LMADS4 mRNA were detected in the inflorescence meristem, in floral buds of different developmental stages, and in all four whorls of the flower organ. LMADS4 mRNA is also expressed in vegetative leaf and in the inflorescence stem where LMADS3 expression is absent. Transgenic Arabidopsis, which ectopically expresses LMADS3, showed novel phenotypes by significantly reducing plant size, flowering extremely early, and loss of floral determinacy. By contrast, 35S::LMADS4 transgenic plants were morphologically indistinguishable from wild-type plants. The early-flowering phenotype in 35S::LMADS3 transgenic Arabidopsis plants was correlated with the up-regulation of flowering time genes FT, SUPPRESSOR OF OVEREXPRESSION OF CO 1, LUMINIDEPENDENS, and flower meristem identity genes LEAFY and APETALA1. This result was further supported by the ability of 35S::LMADS3 to rescue the late-flowering phenotype in gigantea-1 (gi-1), constans-3 (co-3), and luminidependens-1 but not for ft-1 or fwa-1 mutants. The activation of these flowering time genes is, however, indirect because their expression was unaffected in plants transformed with LMADS3 fused with rat glucocorticoid receptor in the presence of both dexamethasone and cycloheximide.

Published
2003

27. Ectopic Expression of Carpel-Specific MADS Box Genes from Lily and Lisianthus Causes Similar Homeotic Conversion of Sepal and Petal in Arabidopsis1

Author

Tzeng, Tsai-Yu, Chen, Hsing-Yu, and Yang, Chang-Hsien

Subjects
Sequence Homology, Amino Acid, Molecular Sequence Data, Arabidopsis, food and beverages, MADS Domain Proteins, Flowers, Gentianaceae, Plants, Genetically Modified, Phenotype, Gene Expression Regulation, Plant, Microscopy, Electron, Scanning, Amino Acid Sequence, Lilium, RNA, Messenger, Phylogeny, Research Article, Plant Proteins
Abstract

Two MADS box genes, Lily MADS Box Gene 2 (LMADS2) and Eustoma grandiflorum MADS Box Gene 1 (EgMADS1), with an extensive similarity to the petunia (Petunia hybrida) FLORAL BINDING PROTEIN 7/11 and Arabidopsis AGL11, were characterized from the lily (Lilium longiflorum) and lisianthus (Eustoma grandiflorum). The expression of LMADS2 and EgMADS1 mRNA was restricted to the carpel and was absent in the other flower organs or vegetative leaves. LMADS2 mRNA was detected mainly in ovules and weakly in style tissues of the carpel, whereas EgMADS1 mRNA was only expressed in the ovules. Transgenic Arabidopsis plants ectopically expressing LMADS2 or EgMADS1 showed similar novel phenotypes resembling 35S::AGAMOUS plants by significantly reducing plant size, flowering early, and losing inflorescence indeterminacy. Ectopic expression of these two genes also generated similar ap2-like flowers by inducing homeotic conversion of the sepals into carpel-like structures in which stigmatic papillae and ovules were observed. In addition, the petals were converted into stamen-like structures in the second whorl of 35S::LMADS2 and 35S::EgMADS1 transgenic Arabidopsis. Our data indicated that LMADS2 and EgMADS1 are putative D functional MADS box genes in lily and lisianthus with a function similar to C functional genes once ectopically expressed in Arabidopsis.

Published
2002

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