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179 results on '"Tziakas, D"'

1. Epidemiology, reperfusion management, and outcomes of patients with myocardial infarction in Greece: The ILIAKTIS study

Author

Kanakakis, I., Tselegkidi, M.E., Sertedaki, E., Mamarelis, I., Fraggos, E., Mantzouranis, E., Karvounis, C., Manolis, A.J., Chatzilymperis, G., Chiotelis, I., Gryllis, D., Poulimenos, L.E., Triantafyllis, A., Alexopoulos, D., Varlamos, C., Almpanis, G., Aggeli, A., Sakkas, A., Trikas, A., Tsiamis, S., Triantafylloy, K., Mpenia, D., Oikonomou, D., Papadopoulou, E., Avramidis, D., Kousta, M., Moulianitaki, E., Poulianitis, G., Mavrou, G., Latsios, G., Synetos, A., Tousoulis, D., Kafkas, N., Godwin, S., Mertzanos, G., Koytouzis, M., Tsiafoutis, I., Papadopoulos, A., Tsoumeleas, A., Barbetseas, I., Sanidas, I., Athanasiou, A., Paizis, I., Kakkavas, A., Papafanis, T., Mantas, I., Neroutsos, G., Gkoliopoulou, A., Tafrali, V., Diakakis, G., Grammatikopoulos, K., Sinanis, T., Kartalis, A., Afendoulis, D., Voutas, P., Kardamis, C., Doulis, A., Kalantzis, N., Vergis, K., Chasikidis, C., Armatas, G., Damelou, A., Ntogka, M., Serafetinidis, I., Zagkas, K., Tselempis, T., Makridis, P., Karantoumanis, I., Karapatsoudi, E., Oikonomou, K., Foukarakis, E., Kafarakis, P., Pitarokoilis, M., Rogdakis, E., Stavrakis, S., Koudounis, G., Karampetsos, V., Lionakis, N., Panotopoulos, C., Svoronos, D., Tsorlalis, I., Tsatiris, K., Beneki, E., Papadopoulos, N., Sawafta, A., Kozatsani, D., Spyromitros, G., Bostanitis, I., Dimitriadis, G., Nikoloulis, N., Kampouridis, N., Giampatzis, V., Patsilinakos, S., Andrikou, E., Katsiadas, N., Papanagnou, G., Kotsakis, A., Ioannidis, E., Platogiannis, N., Psychari, S., Pissimissis, E., Gavrielatos, G., Maritsa, D., Papakonstantinou, N., Patsourakos, N., Oikonomou, G., Katsanou, K., Lazaris, E., Moschos, N., Giakoumakis, T., Papagiannis, N., Goudis, C., Daios, S., Devliotis, K., Dimitriadis, F., Giannadaki, M., Savvidis, M., Tsinopoulos, G., Zarifis, I., Askalidou, T., Vasileiadis, I., Kleitsiotou, P., Sidiropoulos, S., Tsaousidis, A., Tzikas, S., Vassilikos, V., Papadopoulos, C., Zarvalis, Ε., Gogos, C., Moschovidis, V., Styliadis, I., Laschos, V., Spathoulas, K., Vogiatzis, I., Kasmeridis, C., Pittas, S., Sdogkos, E., Dagre, A., Mpounas, P., Rodis, I., Pipilis, A., Konstantinidis, S., Makrygiannis, S., Masdrakis, A., Magginas, A., Sevastos, G., Katsimagklis, G., Skalidis, E., Petousis, S., Davlouros, P., Tsigkas, G., Hahalis, G., Koufou, E., Tziakas, D., Chalikias, G., Thomaidi, A., Stakos, D., Chotidis, A., Nikas, D., Sakellariou, X., Skoularigkis, I., Dimos, A., Iakovis, N., Mpourazana, A., Zagouras, A., Lygkouri, G., Bamidis, P., Lagakis, P., Spachos, D., Stafylas, P., Chalitsios, C.V., Karaiskou, M., Tychala, C., Kanakakis, Ioannis, Stafylas, Panagiotis, Tsigkas, Grigorios, Nikas, Dimitris, Synetos, Andreas, Avramidis, Dimitrios, Tsiafoutis, Ioannis, Dagre, Anna, Tzikas, Stergios, Latsios, Giorgos, Patsourakos, Nikos, Sanidas, Ilias, Skalidis, Emmanouil, Pipilis, Athanasios, Bamidis, Panagiotis, and Davlouros, Periklis

Published
2022
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3. One-Year Outcomes in Anticoagulated Atrial Fibrillation Patients Undergoing Percutaneous Coronary Intervention: Insights from the Greek Antiplatelet Atrial Fibrillation Registry

Author

Alexopoulos, D. Dragona, V.-M. Varlamos, C. Ktenas, D. Lianos, I. Patsilinakos, S. Sionis, D. Zarifis, I. Bampali, T. Poulimenos, L. Skalidis, E. Pissimisis, E. Trikas, A. Tsiafoutis, I. Kafkas, N. Olympios, C. Tziakas, D. Ziakas, A. Voudris, V. Kanakakis, I. Tsioufis, C. Davlouros, P. Benetou, D.-R. and Alexopoulos, D. Dragona, V.-M. Varlamos, C. Ktenas, D. Lianos, I. Patsilinakos, S. Sionis, D. Zarifis, I. Bampali, T. Poulimenos, L. Skalidis, E. Pissimisis, E. Trikas, A. Tsiafoutis, I. Kafkas, N. Olympios, C. Tziakas, D. Ziakas, A. Voudris, V. Kanakakis, I. Tsioufis, C. Davlouros, P. Benetou, D.-R.

Published
2023

4. Geographic variation in heart failure with reduced ejection fraction: insights from the VICTORIA trial

Author

Tsutsui, H, primary, Lam, C S P, additional, Zhang, J, additional, Godoy-Palomino, A, additional, Tziakas, D, additional, Cohen-Solal, A, additional, Freitas, C, additional, Patel, M J, additional, Ezekowitz, J A, additional, Hernandez, A F, additional, Pieske, B, additional, O'Connor, C M, additional, Westerhout, C M, additional, Alemayehu, W, additional, and Armstrong, P W, additional

Published
2022
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6. Angiotensin receptor-neprilysin inhibition in patients with acute decompensated heart failure: an expert consensus position paper

Author

Ntalianis, A. Chrysohoou, C. Giannakoulas, G. Giamouzis, G. Karavidas, A. Naka, A. Papadopoulos, C.H. Patsilinakos, S. Parissis, J. Tziakas, D. Kanakakis, J. and Ntalianis, A. Chrysohoou, C. Giannakoulas, G. Giamouzis, G. Karavidas, A. Naka, A. Papadopoulos, C.H. Patsilinakos, S. Parissis, J. Tziakas, D. Kanakakis, J.

Abstract

The short-term mortality and rehospitalization rates after admission for acute heart failure (AHF) remain high, despite the high level of adherence to contemporary practice guidelines. Observational data from non-randomized studies in AHF strongly support the in-hospital administration of oral evidence-based modifying chronic heart failure (HF) medications (i.e., b-blockers, ACE inhibitors, mineralocorticoid receptor antagonists) to reduce morbidity and mortality. Interestingly, a well-designed prospective randomized multicenter study (PIONEER-HF) showed an improved clinical outcome and stress/injury biomarker profile after in-hospital administration of sacubitril/valsartan (sac/val) as compared to enalapril, in hemodynamically stable patients with AHF. However, sac/val implementation during hospitalization remains suboptimal due to the lack of an integrated individualized plan or well-defined appropriateness criteria for transition to oral therapies, an absence of specific guidelines regarding dose selection and the up-titration process, and uncertainty regarding patient eligibility. In the present expert consensus position paper, clinical practical recommendations are proposed, together with an action plan algorithm, to encourage and facilitate sac/val administration during hospitalization after an AHF episode with the aim of improving efficiencies of care and resource utilization. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Published
2022

7. Electronic medical registry of acute coronary syndromes in Greece. (ILIAKTIS study): Rationale and study design

Author

Kanakakis, I., Tselegkidi, M.E., Sertedaki, E., marelis, I., Fragkos, E., Mantzouranis, E., Karvounis, C., Zafeiropoulos, S., Manolis, A.J., Chatzilymperis, G., Chiotelis, I., Gryllis, D., Poulimenos, L.E., Triantafyllis, A., Alexopoulos, D., Varlamos, C., Almpanis, G., Aggeli, A., Sakkas, A., Trikas, A., Tsiamis, S., Triantafylloy, K., Mpenia, D., Oikonomou, D., Papadopoulou, E., Avramidis, D., Kousta, M., Moulianitaki, E., Poulianitis, G., Mavrou, G., Latsios, G., Synetos, A., Tousoulis, D., Kafkas, N., Godwin, S., Mertzanos, G., Koytouzis, M., Tsiafoutis, I., Papadopoulos, A., Tsoumeleas, A., Barbetseas, I., Sanidas, I., Athanasiou, A., Paizis, I., Kakkavas, A., Papafanis, T., Mantas, I., Neroutsos, G., Gkoliopoulou, A., Tafrali, V., Florou, N., Diakakis, G., Grammatikopoulos, K., Sinanis, T., Kartalis, A., Afendoulis, D., Voutas, P., Kardamis, C., Doulis, A., Kalantzis, N., Vergis, K., Chasikidis, C., Armatas, G., Damelou, A., Ntogka, M., Serafetinidis, I., Zagkas, K., Tselempis, T., Makridis, P., Karantoumanis, I., Karapatsoudi, E., Oikonomou, K., Foukarakis, E., Kafarakis, P., Pitarokoilis, M., Rogdakis, E., Stavrakis, S., Koudounis, G., Karampetsos, V., Lionakis, N., Panotopoulos, C., Svoronos, D., Tsorlalis, I., Tsatiris, K., Beneki, E., Papadopoulos, N., Sawafta, A., Kozatsani, D., Spyromitros, G., Bostanitis, I., Dimitriadis, G., Nikoloulis, N., Kampouridis, N., Giampatzis, V., Patsilinakos, S., Andrikou, E., Katsiadas, N., Papanagnou, G., Kotsakis, A., Ioannidis, E., Platogiannis, N., Psychari, S., Pissimissis, E., Patsourakos, N., Gavrielatos, G., Maritsa, D., Papakonstantinou, N., Oikonomou, G., Katsanou, K., Lazaris, E., Moschos, N., Giakoumakis, T., Papagiannis, N., Goudis, C., Daios, S., Devliotis, K., Dimitriadis, F., Giannadaki, M., Savvidis, M., Tsinopoulos, G., Zarifis, I., Askalidou, T., Vasileiadis, I., Kleitsiotou, P., Sidiropoulos, S., Tsaousidis, A., Tzikas, S., Vassilikos, V., Papadopoulos, C., Zarvalis, E., Gogos, C., Moschovidis, V., Styliadis, I., Laschos, V., Spathoulas, K., Vogiatzis, I., Kasmeridis, C., Pittas, S., Sdogkos, E., Dagre, A., Mpounas, P., Rodis, I., Pipilis, A., Konstantinidis, S., Makrygiannis, S., Masdrakis, A., Magginas, A., Sevastos, G., Katsimagklis, G., Mastrokostopoulos, A., Papaioannou, S., Skalidis, E., Petousis, S., Davlouros, P., Tsigkas, G., Hahalis, G., Koufou, E., Tziakas, D., Chalikias, G., Thomaidi, A., Stakos, D., Chotidis, A., Nikas, D., Sakellariou, X., Skoularigkis, I., Dimos, A., Iakovis, N., Mpourazana, A., Zagouras, A., Ntalas, I., Theodoridou, S., Papagoras, G., Tsoumis, C., Pappa, E., Kotsia, A., Toli, E., Mantzoukis, S., Revi, E., Stafylas, P., Karaiskou, M., Bamidis, P., Lagakis, P., Spachos, D., Lygkouri, G., Kanakakis, Ioannis, Stafylas, Panagiotis, Avramidis, Dimitrios, Dagre, Anna, Latsios, George, Nikas, Dimitris, Patsourakos, Nikos, Pipilis, Athanasios, Sanidas, Ilias, Skalidis, Emmanouil, Synetos, Andreas, Tziakas, Dimitrios, Tzikas, Stergios, Tsiafoutis, Ioannis, Tsigkas, Grigoris, and Bamidis, Panagiotis

Published
2021
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11. Expert consensus statement for the management of patients with embolic stroke of undetermined source and patent foramen ovale: A clinical guide by the working group for stroke of the Hellenic Society of Cardiology and the Hellenic Stroke Organization

Author

Ntaios, G. Tzikas, A. Vavouranakis, E. Nikas, D. Katsimagklis, G. Koroboki, E. Manolis, A.S. Milionis, H. Papadopoulos, K. Sideris, S. Spengos, K. Toutouzas, K. Tziakas, D. Vassilopoulou, S. Kanakakis, I. Vemmos, K. Tsioufis, K.

Published
2020

12. Management of iron deficiency in chronic heart failure: Practical considerations for clinical use and future directions

Author

Nikolaou, M. Chrysohoou, C. Georgilas, T.A. Giamouzis, G. Giannakoulas, G. Karavidas, A. Papadopoulos, C. Patsilinakos, S. Tziakas, D. Parissis, J. for the Hellenic Iron Consensus Group

Abstract

Heart Failure (HF) is a global pandemic with rapidly increasing prevalence. In an attempt to maintain patients well being, the therapeutic interest has expanded to the vicious cycles that confer to HF mortality and morbidity and a number of comorbidities have been targeted. Iron deficiency represents a common comorbid condition that affects outcomes in HF. The treatment of iron deficiency is strongly supported by the cardiologic societies all over the world. Intravenous iron, primarily ferric carboxymaltose, has shown clinical benefit in this setting, irrespective of the anemia status. Practical recommendations though are lacking. In this document, we have tried to cover the practical gap and provide useful details for intravenous iron use. © 2019 European Federation of Internal Medicine

Published
2019

13. Evolocumab and clinical outcomes in patients with cardiovascular disease

Author

Sabatine, Marc S., Giugliano, Robert P., Keech, Anthony C., Honarpour, Narimon, Wiviott, Stephen D., Murphy, Sabina A., Kuder, Julia F., Wang, Huei, Liu, Thomas, Wasserman, Scott M., Sever, Peter S., Pedersen, Fish MP, Terje R., Abrahamsen, Te, Im, K, Kanevsky, E, Bonaca, Mp, Lira Pineda, A, Hanlon, K, Knusel, B, Somaratne, R, Kurtz, C, Scott, R, Accini Mendoza JL, Amerena, J, Badariene, J, Burgess, L, Ceska, R, Charng, Mj, Choi, D, Cobos, Jl, Dan, Ga, De Ferrari GM, Deedwania, Pc, Chopra, Vk, Erglis, A, Ezhov, Mv, Ferreira, J, Filipová, S, Gaciong, Za, Pasierski, T, Georgiev, Bg, Gonzalez-Galvez, G, Gouni-Berthold, I, Schäufele, T, Hirayama, A, Huber, K, Rammer, M, Kjaerulf Jensen, H, Wermuth, S, Jiang, L, Jukema, Jw, Kraydashenko, O, Leiter, La, Lewis, Bs, López-Miranda, J, Lorenzatti, Aj, Mach, F, Mcadam, B, Nilsson, L, Olsson, Å, Rallidis, L, Rogelio, Gg, Kerr Saraiva JF, Scheen, A, Schiele, F, Scott, Rs, Connolly, D, Siu, Cw, Tay, L, Thorgeirsson, G, Tikkanen, Mj, Tokgozoglu, Sl, Toth, K, Viigimaa, M, Wan Ahmad WA, Hennekens, Ch, Andreotti, F, Baigent, C, Brown, Wv, Davis, Br, Newcomer, Jw, Wood, Sk, Larosa, J, Ansell, B, Olsson, A, Lowe, C, Zahn, L, Awtry, E, Berger, C, Croce, K, Desai, A, Gelfand, E, Ho, C, Leeman, D, Link, M, Norden, A, Pande, A, Rost, N, Ruberg, F, Silverman, S, Singhal, A, Vita, J, Mackinnon, I, Vogel, Dr, Leon de la Fuente, R, Perna, E, Amuchastegui, M, Pacora, F, Hershson, A, Blumberg, E, Glenny, Ja, Colombo, H, Cuadrado, Ja, Nicolosi, L, Rojas, Cg, Ulla, Mr, Hasbani, Eg, Cuneo, C, Lopez Santi RG, Sanabria, Hd, Hrabar, A, Lozada, A, Begg, A, Lehman, S, Wittert, G, Juergens, C, Kostner, K, Beltrame, J, Simpson, R, Sinhal, A, Adams, M, Kritharides, L, Roberts Thomson, P, Cross, D, Thompson, P, Van Gaal, W, Cox, N, Farshid, A, Hammett, C, Garrahy, P, Prasan, A, Horrigan, M, Ebenbichler, C, Hanusch, U, Prager, R, Schernthaner, G, Luger, A, Siostrzonek, P, Toplak, H, Bergler-Klein, J, Paulweber, B, Sinzinger, H, Buysschaert, I, Thoeng, J, Vandekerckhove, H, Catez, E, Verheye, S, Descamps, O, Hoffer, E, Wollaert, B, Chenu, P, van de Borne, P, De Meulemeester, M, Friart, A, Charlier, F, De Raedt, H, Rietzschel, E, Roelandt, R, Lalmand, J, Tavares Russo LA, Reis, G, Duarte Barbosa EC, Vidotti, Mh, Fernandes Manenti ER, Dutra, O, Leaes, Pe, Rech, Rl, Bertolim Precoma, D, Nicolau, Jc, Amoedo, R, Eliaschewitz, Fg, Pereira, A, Kurtz Lisboa HR, Soares Piegas, L, Cunha Borges JL, Ferreira Rossi PR, Pimentel Filho, P, Bodanese, Lc, de Sa Cunha, R, Moura Jorge JC, Ardito, Wr, Barroso de Souza WK, Hissa, M, Izar, Mc, Manolova, A, Kitova, L, Kinova, E, Tzekova, M, Velchev, V, Tarnovska-Kadreva, R, Gotchev, D, Petrov, I, Raev, D, Trendafilova-Lazarova, D, Yotov, Y, Lazov, P, Rahimi, S, St Amour, E, Constance, C, Pesant, Y, Hess, A, Anderson, T, Sussex, B, Henein, S, Tsoukas, G, Pandey, As, Bergeron, J, Hart, R, Gosselin, G, Chehayeb, R, Hamet, P, Hartleib, M, Mukherjee, A, Halperin, F, Petrella, R, Bhargava, R, Lonn, E, Sabbah, E, Bata, I, Cha, J, Gaudet, D, Chapman, K, Murthy, D, Nigro, F, Rupka, D, Gossard, D, Gupta, M, Dowell, A, Mansour, S, Baass, A, Geadah, C, Huynh, T, Peterson, S, Poirier, P, Sabe-Affaki, G, Vertes, G, Crowley, D, Duchesne, L, Pincetti Jofre CP, Potthoff Cardenas, S, Conejeros Kindel, C, Saavedra Gajardo VA, Lanas Zanetti, F, Sepulveda Varela PA, Stockins Fernandez BA, Li, W, Li, D, Zhao, S, Li, Z, Wang, J, Yang, Y, Zhang, L, Yang, P, Zhang, X, Huang, H, Xue, L, Zheng, Z, Huang, W, Dai, H, Su, H, Zeng, X, Zheng, Y, Tang, Y, Yao, Z, Sun, Y, Du, Y, Ge, Z, Yan, J, Chen, X, Liu, F, Pei, H, Yang, X, Cui, H, Gu, Y, Yang, Z, Li, J, Lian, Y, Cui, Y, Wang, D, Jiang, J, Li, X, Chen, J, Mo, Z, Xu, P, He, Y, Zhou, C, Qu, P, Zhu, Y, Liu, Y, Shen, X, Gao, X, Terront Lozano MA, Moncada Corredor MA, Hernandez Triana, E, Botero Lopez, R, Coronel Arroyo JA, Quintero Baiz AE, Sanchez Vallejo, G, Arana Londoño, C, Molina de Salazar DI, Castellanos Bueno, R, Manzur Jattin, F, Cure Cure CA, Sotomayor Herazo, A, Spinar, J, Hala, T, Machkova, M, Klimsa, Z, Polasek, R, Jerabek, O, Kazdera, P, Pozdisek, Z, Vaclavik, J, Frana, P, Elbl, L, Kucera, D, Kryza, R, Malecha, J, Reichert, P, Sochor, K, Ludka, O, Kellnerova, I, Peterka, K, Zidkova, E, Cech, V, Brabec, T, Fiserova, N, Kvasnicka, J, Rosolova, H, Nemecek, E, Adamkova, V, Dunaj, M, Pojsl, S, Cepelak, M, Podpera, I, Kuchar, L, Rysava, D, Burianova, H, Spinarova, L, Skrobakova, J, Charvat, J, Homza, M, Zemanek, J, Koleckar, P, Karen, I, Krupicka, J, Blaha, V, Matuska, J, Brotanek, J, Cifkova, R, Kuchar, R, Vomacka, Z, Kosek, Z, Hulinsky, V, Krejcova, H, Kuchar, J, Jelinek, Z, Jelinek, P, Markdanner Lindgren, L, Saetre Lihn, A, Korsgaard Thomsen, K, Bronnum-Schou, J, Nielsen, H, Nielsen, T, Egstrup, K, Klausen, Ic, Mickley, H, Hove, J, Jeppesen, J, Melchior, T, Schmidt, Eb, Valter, I, Rosenthal, A, Kaik, J, Kork, A, Alt, I, Strand, J, Nieminen, S, Kahri, J, Suomi, J, Nyman, K, Strandberg, Te, Piippo, T, Savolainen, M, Vikman, S, Pucheu, Y, Cariou, B, Henry, P, Ferrari, E, Montalescot, G, Ferrieres, J, Roubille, F, Bonnet, B, Angoulvant, D, Range, G, Bammert, A, Delarche, N, Mariat, C, Cayla, G, Durlach, V, Coisne, D, Paillard, F, Rouzier, R, Goralski, M, Khanoyan, P, Cottin, Y, Ziegler, O, Khalife, K, Le Corvoisier, P, Motreff, P, Spaulding, C, Vanbelle, E, Bourhaial, H, Opitz, C, Kahrmann, G, Contzen, C, Appel, K, Schenkenberger, I, Rinke, A, Trenk, D, Maus, O, Karakas, M, Hanefeld, M, Darius, H, Hetzel, G, Münzel, T, Wöhrle, J, Stawowy, P, Marten, I, Isermann, B, Kast, P, Vorpahl, M, Bosiljanoff, P, Hengstenberg, C, Kassner, U, Salbach, P, Fischer, M, Steiner, S, Wagner, S, Kraatz, U, von Hodenberg, E, Weyland, K, Mantas, I, Tziakas, D, Bousboulas, S, Patsilinakos, S, Mertzanos, G, Panagoulis, C, Bilianou, H, Skoumas, I, Elisaf, M, Manolis, A, Moschos, N, Kochiadakis, G, Ntaios, G, Richter, D, Athyros, V, Kolovou, G, Danias, P, Melidonis, A, Fan, Kyy, Siu, Sc, Hornyik, A, Lakatos, F, Zilahi, Z, Nagy, K, Laszlo, Z, 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Yamashita, K, Yasumura, Y, Yuge, M, Hosokawa, S, Kawamitsu, K, Kozuma, K, Matsuo, H, Nakashima, E, Okada, M, Wada, A, Yokoya, K, Iwade, K, Kawabata, K, Tanno, H, Ako, J, Fujita, H, Izumiya, Y, Kanno, M, Nunohiro, T, Ohmura, H, Ueno, T, Kakurina, N, Jasinkevica, I, Stukena, I, Veze, I, Eglite, R, Teterovska, D, Sime, I, Strazdiene, V, Venceviciene, L, Gustiene, O, Radzeviciene-Jurgute, R, Kucinskiene, A, Maskon, O, Lee, C, Erng, T, Gan, H, Mohamed Yusof, A, Ramanathan, G, Liew, H, Lopez Alvarado, A, Nevarez Ruiz, L, De los Rios Ibarra, M, Bazzoni Ruiz, A, Ramos Lopez, G, Llamas Esperon, G, De la Pena Topete, G, Violante Ortiz, R, Illescas Diaz, J, Leon Gonzalez, S, Sanchez Diaz, C, Mendez Machado, G, Venegas Carrillo, L, Aldrete Velasco, J, Cardona Munoz, E, Leiva Pons, J, Perez Alva, J, van der Zwaan, C, Oomen, A, van de Wal, R, Magro, M, Boswijk, D, Janus, C, Groutars, R, Tonino, W, Cornel, J, Oude Ophuis, A, Troquay, R, Liem, A, Westendorp, I, Van Hessen, M, Lok, D, De Nooijer, C, Den Hartog, F, Van Beek, E, Bendermacher, P, Jansen, R, Romer, T, Rensing, B, Hersbach, F, Herrman, J, Ladyjanskaia, G, Karalis, I, Linssen, G, Bokern, M, Visman, A, Kooij, A, Monajemi, H, Lieverse, A, Baker, J, Tie, S, Risberg, K, Hysing, J, Hoivik, H, Norheim, P, Solnor, L, Hovland, A, Kjaernli, T, Jocson, G, Coching, R, Batalla, E, Go, A, Habaluyas, R, Barcinas, R, Sy, R, Estepar, R, Germar, A, Trebacz, J, Szymkowiak, K, Wnetrzak-Michalska, R, Kopaczewski, J, Przekwas-Jaruchowska, M, Kania, G, Zabowka, M, Mirek-Bryniarska, E, Dabrowska, M, Napora, P, Konieczny, M, Spyra, J, Lysek, R, Pijanowski, Z, Grzegorzewski, B, Bednarkiewicz, Z, Kinasz, L, Antkowiak-Piatyszek, K, Stania, K, Szpajer, M, Staneta, P, Skonieczny, G, Ksiezycka-Majczynska, E, Blicharski, T, Piepiorka, M, Wozakowska-Kaplon, B, Zechowicz, T, Ilkowski, J, Lubiszewska, B, Hiczkiewicz, J, Wierzbicka, K, Kosior, D, Garbocz, P, Kubica, J, Raczak, G, Wozniak, I, Cygler, J, Kramarczuk, E, Bystryk, L, Pentela-Nowicka, J, Dabrowski, M, Podolec, P, Zieba, B, Mosiewicz, J, Dubaniewicz, W, Banach, M, Tyszecka, G, Lepich, T, Rychlewska-Hanczewska, A, Guzik, T, Monteiro, P, Pereira, H, Oliveira, L, Matos, P, Soares Goncalves, S, Leitao, A, Vasco Salgado, A, Timoteo, A, Pintilei, E, Badila, E, Militaru, C, Tudoran, M, Arsenescu-Georgescu, C, Mitu, F, Zdrenghea, D, Lighezan, D, Teodorescu, I, Popescu, M, Coman, I, Vintila, M, Vishnevsky, A, Lukyanov, Y, Blokhin, A, Kostenko, V, Shvarts, Y, Markov, V, Motylev, I, Dronov, D, Sherenkov, A, Barbarash, O, Shutemova, E, Bolshakova, O, Kobalava, Z, Voevoda, M, Treshkur, T, Zrazhevskiy, K, Pimenov, L, Solovev, O, Tarasov, N, Arkhipov, M, Freidlin, M, Shalaev, S, Yakhontova, P, Shustov, S, Goloshchekin, B, Panov, A, Bart, B, Bubnova, M, Gordeev, I, Osipova, I, Tereshenko, S, Solovieva, E, Meshkov, A, Zateyshchikov, D, Tan, J, Subramaniam, T, Pella, D, Fulop, P, Antalik, L, Dzupina, A, Banikova, A, Sosovec, D, Urgeova, L, Mazur, J, Hranai, M, Banik, M, Vinanska, D, Lennerova, J, Kovar, F, Pastrnakova, E, Uhliar, R, Blasko, P, Gonsorcik, J, Lukacova, J, Oriesek, R, Hatalova, K, du Toit, M, Ebrahim, I, Vawda, G, Lipschitz, S, Blignaut, S, Engelbrecht, J, Coetzer, T, Pretorius, M, Urbach, D, Badat, A, Pillay, S, Van Zyl, L, Abelson, M, van der Walt, E, Moodley, R, Jacovides, A, Oosthuysen, W, Klug, E, Lottering, H, Kok, J, Saaiman, J, Dawood, S, De Jong, D, Kapp, C, Makotoko, E, Bayat, J, Sarvan, M, Vally, T, Stapelberg, A, Kim, M, Bae, J, Cho, Y, Kim, S, Han, K, Her, S, Kim, B, Lee, S, Hong, B, Kim, W, Rha, S, Jeong, M, Shin, G, Vida Gutierrez, M, Valdes Chavarri, M, Pinto Sala, X, Gonzalez Juanatey, J, Civeira Murillo, F, Zamorano Gomez, J, Lekuona Goya, I, Iniguez Romo, A, Cordero Fort, A, Ascaso Gimilio, J, Millan Nunez-Cortes, J, Lindholm, C, Soderberg, S, Suutari, A, Berglund, S, Mooe, T, Kusiak, D, Bandh, S, Dahlen, G, Olsson, S, Witt, N, Tyden, P, Johansson, P, Cizinsky, S, Falck, G, Pettersson, S, Rasmanis, G, Ostergren, J, Moccetti, T, Beer, H, Eberli, F, Krahenbuhl, S, Linka, A, Ackermann, D, Michel, P, Yeh, H, Tsai, C, Wu, C, Hsia, C, Juang, J, Hsieh, I, Lai, W, Huang, C, Hsieh, Y, Sahin, T, Duzenli, M, Yigit, Z, Demir, M, Yilmaz, M, Muderrisoglu, I, Kirma, C, Ercan, E, Kayikcioglu, L, Balbay, Y, Lymar, I, Kulynych, O, Prokhorov, O, Karpenko, O, Kraіz, I, Vakaliuk, I, Stanislavchuk, M, Korzh, O, Rudyk, I, Zhurba, S, Svishchenko, Y, Tseluyko, V, Gyrina, O, Reshotko, D, Kopytsya, M, Volkov, V, Myshanych, G, Rebrov, B, Rishko, M, Rudenko, L, Shatylo, V, Parkhomenko, O, Yena, L, Golovchenko, O, Sorokina, I, Malynovsky, Y, Ivan, P, Blagden, M, Dear, H, Mathew, A, Lagocki, S, Kondagunta, V, Ahsan, A, Mckinnon, C, Douglas, F, Thom, S, Fiore, G, Caulfield, M, Lynch, M, Thomas, H, Bain, S, Hall, A, Mcnally, D, Fisher, M, Keeling, P, Al-Bahrani, A, Lip, G, Ellery, A, Purohit, J, Travill, C, Cappuccio, F, Davis, G, Gaunt, R, Adlam, D, Asamoah, N, Jaafar, F, Mccormack, T, Jupp, B, Pye, M, Ainsworth, P, Chauhan, A, Paul, N, Fairlie, H, Fox, C, Muzulu, S, Trevelyan, J, Aggarwal, R, Issa, B, Saravanan, P, Cruickshank, K, Gorog, D, Heller, S, Newby, D, Nicolson, A, Hare, P, Donnelly, P, Rutherfurd, S, de Belder, M, Finlayson, J, Harvey, J, Hoye, A, Kingston, D, Sarkar, D, Negahban, A, Webster, J, Wyatt, N, Muir, S, Cummings, M, Mackenzie, I, Senior, R, Capps, N, Fotherby, K, Mcintyre, H, Aldegather, J, Dixon, L, Saksena, R, Butler, R, Ramstad, D, Pierpont, B, Levinson, D, Mohammed, A, Haddad, T, Goel, A, Dave, K, Haught, W, Desire, A, Hershon, K, Napoli, M, Tami, L, Rothschild, R, Khurana, S, Gupta, D, Cheung, D, Hearne, S, Grubb, S, Miller, A, Baird, I, Marcus, A, Srivastava, S, Forgosh, L, Fritz, R, Mays, M, Bertolet, B, Reddy, J, Khan, M, Nakhle, S, Dill, S, Fishbein, G, Khan, B, Marais, H, Reschak, M, Malone, M, Nadar, V, Whitney, R, Reichman, A, Reyes, H, El Shahawy, M, Rabinowitz, A, Weinstein, D, Farhat, N, Onyema, D, Potu, R, Runquist, L, Barnum, O, Crater, T, Fialkow, J, Shah, A, Thompson, C, Wiseman, A, Doyle, T, Henderson, D, Herzog, W, Schnitzler, R, Carr, K, Davis, M, Nagajothi, N, Olsen, S, Rogers, W, Rubino, J, Singh, I, Tarleton, G, Bhagwat, R, Clardy, D, Jardula, M, Robinson, J, Torres, M, Vijay, N, Farris, N, Lillo, J, Moriarty, P, Recknor, C, Berlacher, P, Christensen, T, Gabra, N, Issa, M, Janik, M, Lawless, A, Molter, D, Stout, E, Brezina, B, Claxton, E, Linsky, R, Poock, J, Remler, R, Roseman, H, Schramm, E, Al-Joundi, T, Amin, J, Hitchcock, J, Isserman, S, Kirstein, J, Rider, J, Shalek, M, Sherman, H, Bernstein, M, Chandra, L, Hatharasinghe, R, Ibrahim, H, Iteld, B, Linzmeyer, K, Seaton, B, Zeig, S, Christofides, E, Dunbar, R, Griffin, S, Kohli, N, Koren, M, Pharr, W, Purdy, D, Spencer, R, Yeoman, G, Banerjee, S, Cheek, H, Engel, E, Hamroff, G, Huling, R, Kozlowski, L, Levin, P, Makam, S, Meengs, M, Bhushan, R, Erickson, B, Herman, L, Lo, E, Mcdowell, E, Mcgrew, F, Miller, M, Ord, J, Webel, R, Wilhoit, G, Wise, J, Yang, E, Budoff, M, Collins, J, Dauber, I, Dobkin, L, Focil, A, Gandy, W, Pasquini, J, Ramos, M, Rodriguez, D, Rosenson, R, Sanford, K, Schlau, A, Snyder, B, Stonesifer, L, Tang, A, De Souza, J, Elam, M, French, J, Guyton, J, Hage Korban, E, Kereiakes, D, King, M, Loh, I, Navarro, J, Simons, R, Tobin, T, Younis, L, Aboufakher, R, Baldari, D, Ballantyne, C, Broughton, R, Eaton, C, Johnston, J, Simon, W, Thomson, S, Vora, K, Youngman, D, Alzohaili, O, Auerbach, E, Brown, C, Burrough, B, Chen, Y, Gilpatrick, M, Landzberg, J, Mitchell, C, Rice, L, Rubenfire, M, Sofley, C, Strobl, D, Atassi, K, Davila, W, Diogo, J, Fagan, T, Joffe, I, Krishna, J, Osea, E, Penny, W, Rowe, W, Shapiro, M, Welker, J, Benton, R, Dobratz, D, Fortuin, F, Graham, J, Henry, B, Kusnick, B, Lutskiy, M, Mcrae, A, Saway, W, Scott, J, Shah, M, Weinberg, B, Zarich, S, Acheatel, R, Case, C, Earl, J, Fernandez, S, Giugliano, G, Handelsman, Y, Hermany, P, Holder, S, Kashyap, M, Khan, A, Lader, E, Peniston, J, Raoof, T, Sacco, J, Shore, K, Spriggs, D, Stringam, S, Tahirkheli, N, Delgado, E, Derian, W, Greenwald, J, Harris, M, Jackson, R, Marhefka, G, Mcelveen, W, Mooss, A, Morris, P, Murray, J, Pearlstein, P, Raisinghani, A, Rezkalla, S, Sakhrani, L, Schreibman, D, Shaoulian, E, Steinsapir, J, Yataco, A, De La Cruz, A, Fredrick, M, Goldenberg, E, Lee, D, Mccullum, K, Mclellan, B, Stephens, L, Wilson, S, Alfieri, A, Mandviwala, M, Orourke, D, Samal, A, Schmedtje, J, Waxman, F, Carhart, R, Clements, B, Dyke, C, Ghali, J, Gruberg, L, Hack, T, Jehle, A, Pogue, B, Schooley, C, and Shifrin, G

Subjects
Male, STATIN THERAPY, 2700 General Medicine, Disease, Cardiovascular, PLACEBO-CONTROLLED TRIAL, Gastroenterology, 0302 clinical medicine, Anticholesteremic Agent, Medicine, Myocardial infarction, 11 Medical and Health Sciences, ddc:616, Incidence, Antibodies, Monoclonal, General Medicine, Cholesterol, Cardiovascular Diseases, Monoclonal, Drug Therapy, Combination, Proprotein Convertase 9, Antibody, Aged, Anticholesteremic Agents, Atherosclerosis, Cholesterol, LDL, Double-Blind Method, Female, Follow-Up Studies, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Hypercholesterolemia, Least-Squares Analysis, Middle Aged, Medicine (all), REDUCING LIPIDS, Human, medicine.medical_specialty, Evinacumab, Clinical Trials and Supportive Activities, PCSK9 INHIBITION, Follow-Up Studie, LDL, 03 medical and health sciences, Drug Therapy, Clinical Research, LDL-C, Least-Squares Analysi, Science & Technology, Unstable angina, PCSK9, medicine.disease, chemistry, Clinical Biochemistry, 030204 cardiovascular system & hematology, Bococizumab, FOURIER Steering Committee and Investigators, Medical and Health Sciences, chemistry.chemical_compound, Antibodies monoclonal, Cardiovascular Disease, 030212 general & internal medicine, Stroke, Humanized, RISK, biology, PCSK9 Inhibitors, 10051 Rheumatology Clinic and Institute of Physical Medicine, Heart Disease, Atherosclerosi, 6.1 Pharmaceuticals, Combination, Cardiology, Life Sciences & Biomedicine, Antibodies, Monoclonal, Humanized, EZETIMIBE, 610 Medicine & health, Antibodies, Medicine, General & Internal, General & Internal Medicine, Internal medicine, CORONARY-HEART-DISEASE, In patient, Heart Disease - Coronary Heart Disease, Alirocumab, Ldl cholesterol, business.industry, Evaluation of treatments and therapeutic interventions, Evolocumab, Good Health and Well Being, Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, biology.protein, MODERATE, Hydroxymethylglutaryl-CoA Reductase Inhibitor, business
Abstract

Background Evolocumab is a monoclonal antibody that inhibits proprotein convertase subtilisin–kexin type 9 (PCSK9) and lowers low-density lipoprotein (LDL) cholesterol levels by approximately 60%. Whether it prevents cardiovascular events is uncertain. Methods We conducted a randomized, double-blind, placebo-controlled trial involving 27,564 patients with atherosclerotic cardiovascular disease and LDL cholesterol levels of 70 mg per deciliter (1.8 mmol per liter) or higher who were receiving statin therapy. Patients were randomly assigned to receive evolocumab (either 140 mg every 2 weeks or 420 mg monthly) or matching placebo as subcutaneous injections. The primary efficacy end point was the composite of cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization. The key secondary efficacy end point was the composite of cardiovascular death, myocardial infarction, or stroke. The median duration of follow-up was 2.2 years. Results At 48 weeks, the least-squares mean percentage reduction in LDL cholesterol levels with evolocumab, as compared with placebo, was 59%, from a median baseline value of 92 mg per deciliter (2.4 mmol per liter) to 30 mg per deciliter (0.78 mmol per liter) (P

Published
2017

15. Expert consensus on the rational clinical use of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors

Author

Achimastos, A. Alexandrides, T. Alexopoulos, D. Athyros, V. Bargiota, A. Bilianou, E. Chrysochoou, C. Drogari, E. Elisaf, M. Ganotakis, E. Goudevenos, I. Ioannidis, I. Kolovou, G. Kotsis, V. Lekakis, I. Liberopoulos, E. Melidonis, A. Nikolaou, V. Ntaios, G. Papanas, N. Pappas, S. Pitsavos, C. Rallidis, L. Richter, D. Skoumas, I. Tentolouris, N. Tousoulis, D. Tselepis, A. Tsioufis, K. Tziakas, D. Tziomalos, K. Vardas, P. Vlachopoulo, C. Vlahakos, D.

Subjects
lipids (amino acids, peptides, and proteins)
Abstract

Two proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, evolocumab and alirocumab, have recently been approved by both the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) for the treatment of hypercholesterolemia. These fully human monoclonal antibodies selectively block PCSK9, thus permitting the low-density lipoprotein (LDL) receptor to effectively recycle to the surface of liver cells. The administration of these antibodies leads to robust LDL cholesterol (LDL-C) lowering by 50-60% on top of maximum hypolipidemic treatment. At least 4 randomized, placebo-controlled studies are under way and will address the question of whether the administration of these PCSK9 inhibitors is associated with a significant reduction of cardiovascular events. Because of the high cost associated with the use of these medications it is very important to consider which patients may gain the most benefit, at least until the results of outcome studies are available. In this Consensus paper, 34 clinicians/scientists define 3 groups of patients that should be currently considered as candidates for the use of these novel drugs. These include: 1a. Adults with established cardiovascular disease and LDL-C≥100 mg/dL while on lifestyle modifications and maximally tolerated hypolipidemic treatment, i.e. high-intensity statin + ezetimibe, 1b. Adults with diabetes and established cardiovascular disease or chronic kidney disease or target organ damage and LDL-C ≥100 mg/dL while on lifestyle modifications and maximally tolerated hypolipidemic treatment, i.e. high-intensity statin + ezetimibe, 2. Adults with familial hypercholesterolemia (FH) without established cardiovascular disease and LDL-C ≥130 mg/dL while on lifestyle modifications and maximally tolerated hypolipidemic treatment, i.e. high-intensity statin + ezetimibe (evolocumab is also indicated in children above 12 years with homozygous FH), and 3. Adults at high or very high cardiovascular risk who are statin intolerant and have an LDL-C ≥100 and ≥130 mg/dL, respectively, while on any tolerated hypolipidemic treatment. © 2016, Hellenic Endocrine Society. All rights reserved.

Published
2016

17. Evolocumab and clinical outcomes in patients with cardiovascular disease

Author

Sabatine, M. S., Giugliano, R. P., Keech, A. C., Honarpour, N., Wiviott, S. D., Murphy, S. A., Kuder, J. F., Wang, H., Liu, T., Wasserman, S. M., Sever, P. S., Pedersen, T. R., Fish, M. P., Abrahamsen, T. E., Im, K., Kanevsky, E., Bonaca, M. P., Lira Pineda, A., Hanlon, K., Knusel, B., Somaratne, R., Kurtz, C., Scott, R., Accini Mendoza, J. L., Amerena, J., Badariene, J., Burgess, L., Ceska, R., Charng, M. J., Choi, D., Cobos, J. L., Dan, G. A., De Ferrari, G. M., Deedwania, P. C., Chopra, V. K., Erglis, A., Ezhov, M. V., Ferreira, J., Filipova, S., Gaciong, Z. A., Pasierski, T., Georgiev, B. G., Gonzalez-Galvez, G., Gouni-Berthold, I., Schaufele, T., Hirayama, A., Huber, K., Rammer, M., Kjaerulf Jensen, H., Wermuth, S., Jiang, L., Jukema, J. W., Kraydashenko, O., Leiter, L. A., Lewis, B. S., Lopez-Miranda, J., Lorenzatti, A. J., Mach, F., Mcadam, B., Nilsson, L., Olsson, A., Rallidis, L., Rogelio, G. G., Kerr Saraiva, J. F., Scheen, A., Schiele, F., Connolly, D., Siu, C. W., Tay, L., Thorgeirsson, G., Tikkanen, M. J., Tokgozoglu, S. L., Toth, K., Viigimaa, M., Wan Ahmad, W. A., Hennekens, C. H., Andreotti, F., Baigent, C., Brown, W. V., Davis, B. R., Newcomer, J. W., Wood, S. K., Larosa, J., Ansell, B., Lowe, C., Zahn, L., Awtry, E., Berger, C., Croce, K., Desai, A., Gelfand, E., Ho, C., Leeman, D., Link, M., Norden, A., Pande, A., Rost, N., Ruberg, F., Silverman, S., Singhal, A., Vita, J., Mackinnon, I., Vogel, D. R., Leon de la Fuente, R., Perna, E., Amuchastegui, M., Pacora, F., Hershson, A., Blumberg, E., Glenny, J. A., Colombo, H., Cuadrado, J. A., Nicolosi, L., Rojas, C. G., Ulla, M. R., Hasbani, E. G., Cuneo, C., Lopez Santi, R. G., Sanabria, H. D., Hrabar, A., Lozada, A., Begg, A., Lehman, S., Wittert, G., Juergens, C., Kostner, K., Beltrame, J., Simpson, R., Sinhal, A., Adams, M., Kritharides, L., Roberts Thomson, P., Cross, D., Thompson, P., Van Gaal, W., Cox, N., Farshid, A., Hammett, C., Garrahy, P., Prasan, A., Horrigan, M., Ebenbichler, C., Hanusch, U., Prager, R., Schernthaner, G., Luger, A., Siostrzonek, P., Toplak, H., Bergler-Klein, J., Paulweber, B., Sinzinger, H., Buysschaert, I., Thoeng, J., Vandekerckhove, H., Catez, E., Verheye, S., Descamps, O., Hoffer, E., Wollaert, B., Chenu, P., van de Borne, P., De Meulemeester, M., Friart, A., Charlier, F., De Raedt, H., Rietzschel, E., Roelandt, R., Lalmand, J., Tavares Russo, L. A., Reis, G., Duarte Barbosa, E. C., Vidotti, M. H., Fernandes Manenti, E. R., Dutra, O., Leaes, P. E., Rech, R. L., Bertolim Precoma, D., Nicolau, J. C., Amoedo, R., Eliaschewitz, F. G., Pereira, A., Kurtz Lisboa, H. R., Soares Piegas, L., Cunha Borges, J. L., Ferreira Rossi, P. R., Pimentel Filho, P., Bodanese, L. C., de Sa Cunha, R., Moura Jorge, J. C., Ardito, W. R., Barroso de Souza, W. K., Hissa, M., Izar, M. C., Manolova, A., Kitova, L., Kinova, E., Tzekova, M., Velchev, V., Tarnovska-Kadreva, R., Gotchev, D., Petrov, I., Raev, D., Trendafilova-Lazarova, D., Yotov, Y., Lazov, P., Rahimi, S., St Amour, E., Constance, C., Pesant, Y., Hess, A., Anderson, T., Sussex, B., Henein, S., Tsoukas, G., Pandey, A. S., Bergeron, J., Hart, R., Gosselin, G., Chehayeb, R., Hamet, P., Hartleib, M., Mukherjee, A., Halperin, F., Petrella, R., Bhargava, R., Lonn, E., Sabbah, E., Bata, I., Cha, J., Gaudet, D., Chapman, K., Murthy, D., Nigro, F., Rupka, D., Gossard, D., Gupta, M., Dowell, A., Mansour, S., Baass, A., Geadah, C., Huynh, T., Peterson, S., Poirier, P., Sabe-Affaki, G., Vertes, G., Crowley, D., Duchesne, L., Pincetti Jofre, C. P., Potthoff Cardenas, S., Conejeros Kindel, C., Saavedra Gajardo, V. A., Lanas Zanetti, F., Sepulveda Varela, P. 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M. (ORCID:0000-0002-6921-6497)

Abstract

BACKGROUND Evolocumab is a monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9) and lowers low-density lipoprotein (LDL) cholesterol levels by approximately 60%. Whether it prevents cardiovascular events is uncertain. METHODS We conducted a randomized, double-blind, placebo-controlled trial involving 27,564 patients with atherosclerotic cardiovascular disease and LDL cholesterol levels of 70 mg per deciliter (1.8 mmol per liter) or higher who were receiving statin therapy. Patients were randomly assigned to receive evolocumab (either 140 mg every 2 weeks or 420 mg monthly) or matching placebo as subcutaneous injections. The primary efficacy end point was the composite of cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization. The key secondary efficacy end point was the composite of cardiovascular death, myocardial infarction, or stroke. The median duration of follow-up was 2.2 years. RESULTS At 48 weeks, the least-squares mean percentage reduction in LDL cholesterol levels with evolocumab, as compared with placebo, was 59%, from a median baseline value of 92 mg per deciliter (2.4 mmol per liter) to 30 mg per deciliter (0.78 mmol per liter) (P<0.001). Relative to placebo, evolocumab treatment significantly reduced the risk of the primary end point (1344 patients [9.8%] vs. 1563 patients [11.3%]; hazard ratio, 0.85; 95% confidence interval [CI], 0.79 to 0.92; P<0.001) and the key secondary end point (816 [5.9%] vs. 1013 [7.4%]; hazard ratio, 0.80; 95% CI, 0.73 to 0.88; P<0.001). The results were consistent across key subgroups, including the subgroup of patients in the lowest quartile for baseline LDL cholesterol levels (median, 74 mg per deciliter [1.9 mmol per liter]). There was no significant difference between the study groups with regard to adverse events (including new-onset diabetes and neurocognitive events), with the exception of injection-site reacti

Published
2017

18. P1007Aortic root diameters and aortic regurgitation in hypertensive patients and normal subjectsP1008Ultrasonic assessment of backscatter signal intensity of the right ventricle in patients with arterial hypertension as a method of measuring alterations of myocardiumP1009Speckle strain echocardiography for the evaluation of left ventricular dyssynchrony in patients with severe lung diseases and pulmonary hypertensionP1010Impaired left ventricular ejection fraction in a cohort of systemic sclerosis patients: clinical and echocardiographic characteristicsP1011Prognostic role of subclinical left ventricular systolic dysfunction evaluated using strain imaging by speckle-tracking echocardiographyP1012Inferior vena cava diameter is a strong and practical marker of physical activity and fitnessP1013When the heart works for two: morphologic and functional adaptation during pregnancyP1014Extensive use of lung ultrasound in pediatric cardiac surgery: preliminary experienceP1015Asymptomatic delayed right ventricular perforation by cardiac implantable electronic devices lead, echocardiographic featuresP1016Novel echocardiographic prognostic markers for cardiac tamponade in patients with large malignant pericardial effusions. A paradigm shift from flow to tissue imagingP1017Doppler echocardiographic parameters as a marker of cardiac tamponadeP1018Sigmoid septum as a marker of elongation of thoracic aorta caused by progression of atherosclerosisP1019Carotid artery atherosclerosis and stiffness: comparison of different metabolic measuresP1020Feasibility of triple imaging vasodilator stress echo in patients with suspected coronary artery diseaseP1022The use of combined echo and cardio-pulmonary stress for discriminating cardiac problems from de-conditioning in patients with dyspneaP1023Long-term prognosis of a stress echocardiography in patients after successful primary percutaneous intervention and incomplete revascularization of non-culprit lesionsP1024Diastolic exercise stress echo can unmask diastolic dysfunction in type 2 diabetes, a five-year follow-up studyP1025Diabetes mellitus is the major limitation for diagnosis of coronary artery disease assessed by semisupine ergometer stress echocardiographyP1026Longitudinal changes of atherosclerotic features in the aorta on transcatheter aortic valve implantation using transesophageal echocardiographyP1027Severe aortic stenosis: comparison between effective and anatomical aortic?valvular area by two and three dimension transesophageal ecocardiographyP1028Region growing method provides better left ventricular volume and cardaic output measuringP10293 dimensional echocardiographic evaluation of mitral valve geometry in patients with secondary and primary mitral regurgitationP1030The impact of adjustable region of interest on ventricular strain measurements and arrhythmic risk assessment in patients with hypertrophic cardiomyopathyP1031Left ventricular strain at presentation predicts long-term outcome in ALCAPA patientsP1032Global atrial-ventricular strain as a new index of subclinical left heart dysfunction in hypertensive and diabetic patients

Author

Vriz, O., primary, Ivanov, S., primary, Szulik, M., primary, Llerena Butron, S., primary, Cioffi, G., primary, Bruin De- Bon, HACM, primary, Meras Colunga, P., primary, Cantinotti, M., primary, Zaborska, B., primary, Chalikias, G., primary, Son, JW., primary, Wada, Y., primary, Di Nora, C., primary, Ciampi, Q., primary, Topilsky, YT., primary, Petrovic, MT., primary, Bjork Ingul, C., primary, Tsai, HR., primary, Bando, M., primary, Perea, G., primary, Cheng, H-L, primary, Schueler, R., primary, Rosca, M., primary, Di Salvo, G., primary, Cameli, M., primary, Bertn, NB., additional, Brosolo, G., additional, Bossone, E., additional, Matveev, V., additional, Kuznetsova, L., additional, Dmitrieva, I., additional, Nowak, J., additional, Skowron, W., additional, Klys, J., additional, Koziel, M., additional, Streb, W., additional, Rozentryt, P., additional, Zeglen, S., additional, Kalarus, Z., additional, Kukulski, T., additional, Denton, CP., additional, Coghlan, JG., additional, Schreiber, BE., additional, Viapiana, O., additional, Ognibeni, F., additional, Dalbeni, A., additional, Giollo, A., additional, Gatti, D., additional, Idolazzi, L., additional, Cherubini, A., additional, Mazzone, C., additional, Faganello, G., additional, Di Lenarda, A., additional, Rossini, M., additional, Jorstad, HT., additional, Boekholdt, SM., additional, Panhuyzen-Goedkoop, NM., additional, Bouma, BJ., additional, Peters, RJG, additional, Prado Diaz, S., additional, Montoro Lopez, N., additional, Gonzalez Fernandez, O., additional, Rial Baston, V., additional, Valbuena Lopez, SC., additional, Refoyo Salicio, E., additional, Moreno Yanguela, M., additional, De?La?Calle, M., additional, Bartha Rasero, JL., additional, Dalmau Gonzalez-Gallarza, R., additional, Lopez Sendon, JL., additional, Guzman Martinez, G., additional, Ait-Ali, L., additional, Franchi, EF., additional, Scalese, M., additional, Gargani, L., additional, Makowska, E., additional, Pilichowska-Paszkiet, E., additional, Sikora-Frac, M., additional, Czepiel, A., additional, Swiatkowski, M., additional, Kulakowski, P., additional, Samaras, A., additional, Kikas, P., additional, Thomaidis, A., additional, Drosos, I., additional, Tziakas, D., additional, Kim, HJ., additional, Kim, BJ., additional, Choi, KW., additional, Nam, JH., additional, Lee, JH., additional, Lee, CH., additional, Kim, W., additional, Park, JS., additional, Shin, DG., additional, Kim, YJ., additional, Choi, JH., additional, Fujii, A., additional, Ariyoshi, T., additional, Okuda, S., additional, Omuro, A., additional, Hisaoka, M., additional, Nao, T., additional, Yamasaki, T., additional, Tanaka, N., additional, Yano, M., additional, Poli, S., additional, Vriz, O., additional, Sparacino, L., additional, Zito, C., additional, Carerj, S., additional, Pavan, D., additional, Antonini-Canterin, F., additional, Paterni, M., additional, Villari, B., additional, Picano, E., additional, Rozenbaum, ZR., additional, Khoury, KS., additional, Keren, GK., additional, Giga, V., additional, Stepanovic, J., additional, Boskovic, N., additional, Trifunovic, D., additional, Aleksandric, S., additional, Nedeljkovic, I., additional, Tesic, M., additional, Dobric, M., additional, Rakocevic, I., additional, Beleslin, B., additional, Djordjevic-Dikic, A., additional, Timilsina, AS., additional, Hollekim-Strand, SM., additional, Liu, YW., additional, Tsai, WC., additional, Nishigami, K., additional, Horibata, Y., additional, Nakao, K., additional, Sakamoto, T., additional, Lombardero, M., additional, Henquin, R., additional, Corneli, MC., additional, Oeztuerk, C., additional, Weber, M., additional, Welz, A., additional, Werner, N., additional, Nickenig, G., additional, Hammerstingl, C., additional, Mandes, L., additional, Calin, A., additional, Beladan, CC., additional, Enache, R., additional, Mateescu, A., additional, Calin, C., additional, Jurcut, R., additional, Ginghina, C., additional, Popescu, BA., additional, Muhanna, N., additional, Siblini, G., additional, Bulbul, Z., additional, Issa, Z., additional, Abu Hazeem, A., additional, Fadel, B., additional, Pergola, V., additional, Halees, Z., additional, Fayyadh, M., additional, Mandoli, GE., additional, Righini, FM., additional, Albizzi, C., additional, Capitani, E., additional, Pastore, C., additional, D'ascenzi, F., additional, Focardi, M., additional, and Mondillo, S., additional

Published
2016
Full Text
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20. A Randomized Trial of Genotype-Guided Dosing of Acenocoumarol and Phenprocoumon

Author

Verhoef, T.I., Ragia, G., Boer, A. de, Barallon, R., Kolovou, G., Kolovou, V., Konstantinides, S., Cessie, S. le, Maltezos, E., Meer, F.J.M. van der, Redekop, W.K., Remkes, M., Rosendaal, F.R., Schie, R.M.F. van, Tavridou, A., Tziakas, D., Wadelius, M., Manolopoulos, V.G., Maitland-van der Zee, A.H., EU-PACT Grp, Pulmonology, APH - Amsterdam Public Health, Epidemiology and Data Science, Cardiology, and Health Economics (HE)

Subjects
Male, medicine.medical_specialty, Genotype, 030204 cardiovascular system & hematology, law.invention, Phenprocoumon, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Internal medicine, Thromboembolism, Vitamin K Epoxide Reductases, medicine, Humans, Single-Blind Method, Dosing, International Normalized Ratio, Treatment Failure, CYP2C9, Aged, Cytochrome P-450 CYP2C9, Acenocoumarol, business.industry, Incidence (epidemiology), Anticoagulants, Atrial fibrillation, General Medicine, Middle Aged, medicine.disease, 3. Good health, Surgery, Pharmacogenetics, 030220 oncology & carcinogenesis, Female, VKORC1, Aryl Hydrocarbon Hydroxylases, business, Algorithms, medicine.drug, Follow-Up Studies
Abstract

BACKGROUND Observational evidence suggests that the use of a genotype-guided dosing algorithm may increase the effectiveness and safety of acenocoumarol and phenprocoumon therapy. METHODS We conducted two single-blind, randomized trials comparing a genotype-guided dosing algorithm that included clinical variables and genotyping for CYP2C9 and VKORC1 with a dosing algorithm that included only clinical variables, for the initiation of acenocoumarol or phenprocoumon treatment in patients with atrial fibrillation or venous thromboembolism. The primary outcome was the percentage of time in the target range for the international normalized ratio (INR; target range, 2.0 to 3.0) in the 12-week period after the initiation of therapy. Owing to low enrollment, the two trials were combined for analysis. The primary outcome was assessed in patients who remained in the trial for at least 10 weeks. RESULTS A total of 548 patients were enrolled (273 patients in the genotype-guided group and 275 in the control group). The follow-up was at least 10 weeks for 239 patients in the genotype-guided group and 245 in the control group. The percentage of time in the therapeutic INR range was 61.6% for patients receiving genotype-guided dosing and 60.2% for those receiving clinically guided dosing (P = 0.52). There were no significant differences between the two groups for several secondary outcomes. The percentage of time in the therapeutic range during the first 4 weeks after the initiation of treatment in the two groups was 52.8% and 47.5% (P = 0.02), respectively. There were no significant differences with respect to the incidence of bleeding or thromboembolic events. CONCLUSIONS Genotype-guided dosing of acenocoumarol or phenprocoumon did not improve the percentage of time in the therapeutic INR range during the 12 weeks after the initiation of therapy. (Funded by the European Commission Seventh Framework Programme and others; EU-PACT ClinicalTrials.gov numbers, NCT01119261 and NCT01119274.)

Published
2013

23. A randomized trial of genotype-guided dosing of acenocoumarol and phenprocoumon

Author

Verhoef, T.I. (Talitha), Ragia, G. (Georgia), Boer, A.C. (Anton) de, Barallon, R. (Rita), Kolovou, G. (Genovefa), Konstantinides, S. (Stavros), Cessie, S. (Saskia) le, Maltezos, E. (Efstratios), Meer, F.J.M. (Felix) van der, Redekop, W.K. (Ken), Remkes, P.A.J., Rosendaal, F.R. (Frits), Schie, R.F.M. (Rianne) van, Tavridou, A. (Anna), Tziakas, D. (Dimitrios), Wadelius, M. (Mia), Manolopoulos, V.G. (Vangelis), Maitland-van der Zee, A-H. (Anke-Hilse), Verhoef, T.I. (Talitha), Ragia, G. (Georgia), Boer, A.C. (Anton) de, Barallon, R. (Rita), Kolovou, G. (Genovefa), Konstantinides, S. (Stavros), Cessie, S. (Saskia) le, Maltezos, E. (Efstratios), Meer, F.J.M. (Felix) van der, Redekop, W.K. (Ken), Remkes, P.A.J., Rosendaal, F.R. (Frits), Schie, R.F.M. (Rianne) van, Tavridou, A. (Anna), Tziakas, D. (Dimitrios), Wadelius, M. (Mia), Manolopoulos, V.G. (Vangelis), and Maitland-van der Zee, A-H. (Anke-Hilse)

Abstract

BACKGROUND: Observational evidence suggests that the use of a genotype-guided dosing algorithm may increase the effectiveness and safety of acenocoumarol and phenprocoumon therapy. METHODS: We conducted two single-blind, randomized trials comparing a genotype-guided dosing algorithm that included clinical variables and genotyping for CYP2C9 and VKORC1 with a dosing algorithm that included only clinical variables, for the initiation of acenocoumarol or phenprocoumon treatment in patients with atrial fibrillation or venous thromboembolism. The primary outcome was the percentage of time in the target range for the international normalized ratio (INR; target range, 2.0 to 3.0) in the 12-week period after the initiation of therapy. Owing to low enrollment, the two trials were combined for analysis. The primary outcome was assessed in patients who remained in the trial for at least 10 weeks. RESULTS: A total of 548 patients were enrolled (273 patients in the genotype-guided group and 275 in the control group). The follow-up was at least 10 weeks for 239 patients in the genotype-guided group and 245 in the control group. The percentage of time in the therapeutic INR range was 61.6% for patients receiving genotype-guided dosing and 60.2% for those receiving clinically guided dosing (P = 0.52). There were no significant differences between the two groups for several secondary outcomes. The percentage of time in the therapeutic range during the first 4 weeks after the initiation of treatment in the two groups was 52.8% and 47.5% (P = 0.02), respectively. There were no significant differences with respect to the incidence of bleeding or thromboembolic events. CONCLUSIONS: Genotype-guided dosing of acenocoumarol or phenprocoumon did not improve the percentage of time in the therapeutic INR range during the 12 weeks after the initiation of therapy. Copyright

Published
2013
Full Text
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24. Poster Session 2: Thursday 8 December 2011, 14:00-18:00 * Location: Poster Area

Author

Luo, X., primary, Fang, F., additional, Sun, J., additional, Xie, J., additional, Lee, A., additional, Zhang, Q., additional, Yu, C., additional, Breithardt, O., additional, Schiessl, S., additional, Schmid, M., additional, Seltmann, M., additional, Klinghammer, L., additional, Zeissler, C., additional, Kuechle, M., additional, Daniel, W., additional, Ege, M., additional, Guray, U., additional, Guray, Y., additional, Demirkan, B., additional, Kisacik, H., additional, Kim, S.-E., additional, Hong, J.-Y., additional, Lee, J.-H., additional, Park, D.-G., additional, Han, K.-R., additional, Oh, D.-J., additional, Tufekcioglu, O., additional, Cozma, D. C., additional, Mornos, C., additional, Ionac, A., additional, Petrescu, L., additional, Tutuianu, C., additional, Dragulescu, S. I., additional, Guimaraes, L., additional, Tavares, G., additional, Rodrigues, A., additional, Nagamatsu, C., additional, Fischer, C., additional, Vieira, M., additional, Oliveira, W., additional, Wilberg, T., additional, Cordovil, A., additional, Morhy, S., additional, Muraru, D., additional, Peluso, M., additional, Dal Bianco, L., additional, Beraldo, M., additional, Solda', E., additional, Tuveri, M., additional, Cucchini, U., additional, Al Mamary, A., additional, Badano, L., additional, Iliceto, S., additional, Pizzuti, A., additional, Mabritto, B., additional, Derosa, C., additional, Tomasello, A., additional, Rovere, M., additional, Parrini, I., additional, Conte, M., additional, Lareva, N., additional, Govorin, A., additional, Cooper, R., additional, Sharif, J., additional, Somauroo, J. D., additional, Hung, J. D., additional, Porcelli, V., additional, Skevington, R., additional, Shahzad, A., additional, Scott, S., additional, Lindqvist, P., additional, Soderberg, S., additional, Gonzalez, M., additional, Tossavainen, E., additional, Henein, M., additional, Nciri, N., additional, Saad, H., additional, Nawas, S., additional, Ali, A., additional, Youssufzay, A., additional, Safi, A., additional, Faruk, S., additional, Yurdakul, S., additional, Erdemir, V., additional, Tayyareci, Y., additional, Yildirimturk, O., additional, Memic, K., additional, Aytekin, V., additional, Gurel, M., additional, Aytekin, S., additional, Przewlocka-Kosmala, M., additional, Cielecka-Prynda, M., additional, Mysiak, A., additional, Kosmala, W., additional, Pescariu, S., additional, Cozma, D., additional, Mornos, A., additional, Dragulescu, S., additional, Maurea, N., additional, Tocchetti, C. G., additional, Coppola, C., additional, Quintavalle, C., additional, Rea, D., additional, Barbieri, A., additional, Piscopo, G., additional, Arra, C., additional, Condorelli, G., additional, Iaffaioli, R., additional, Dalen, H., additional, Thorstensen, A., additional, Moelmen, H., additional, Torp, H., additional, Stoylen, A., additional, Augustine, D., additional, Basagiannis, C., additional, Suttie, J., additional, Cox, P., additional, Aitzaz, R., additional, Lewandowski, A., additional, Lazdam, M., additional, Holloway, C., additional, Becher, H., additional, Leeson, P., additional, Radovanovic, S., additional, Djokovic, A., additional, Todic, B., additional, Zdravkovic, M., additional, Zaja-Simic, M., additional, Banicevic, S., additional, Lisulov-Popovic, D., additional, Krotin, M., additional, Grapsa, J., additional, O'regan, D., additional, Dawson, D., additional, Durighel, G., additional, Howard, L., additional, Gibbs, J., additional, Nihoyannopoulos, P., additional, Tulunay Kaya, C., additional, Kilickap, M., additional, Kurklu, H., additional, Ozbek, N., additional, Koca, C., additional, Kozluca, V., additional, Esenboga, K., additional, Erol, C., additional, Kusmierczyk-Droszcz, B., additional, Kowalik, E., additional, Niewiadomska, J., additional, Hoffman, P., additional, Satendra, M., additional, Sargento, L., additional, Lopes, S., additional, Longo, S., additional, Lousada, N., additional, Palma Reis, R., additional, Chillo, P., additional, Rieck, A., additional, Lwakatare, J., additional, Lutale, J., additional, Gerdts, E., additional, Bonapace, S., additional, Molon, G., additional, Targher, G., additional, Rossi, A., additional, Lanzoni, L., additional, Canali, G., additional, Campopiano, E., additional, Zenari, L., additional, Bertolini, L., additional, Barbieri, E., additional, Hristova, K., additional, Vladiomirova-Kitova, L., additional, Katova, T., additional, Nikolov, F., additional, Nikolov, P., additional, Georgieva, S., additional, Simova, I., additional, Kostova, V., additional, Kuznetsov, V. A., additional, Krinochkin, D. V., additional, Chandraratna, P. A., additional, Pak, Y. A., additional, Zakharova, E. H., additional, Plusnin, A. V., additional, Semukhin, M. V., additional, Gorbatenko, E. A., additional, Yaroslavskaya, E. I., additional, Bedetti, G., additional, Gargani, L., additional, Scalese, M., additional, Pizzi, C., additional, Sicari, R., additional, Picano, E., additional, Reali, M., additional, Canali, E., additional, Cimino, S., additional, Francone, M., additional, Mancone, M., additional, Scardala, R., additional, Boccalini, F., additional, Hiramoto, Y., additional, Frustaci, A., additional, Agati, L., additional, Savino, K., additional, Lilli, A., additional, Bordoni, E., additional, Riccini, C., additional, Ambrosio, G., additional, Silva, D., additional, Cortez-Dias, N., additional, Carrilho-Ferreira, P., additional, Jorge, C., additional, Silva-Marques, J., additional, Magalhaes, A., additional, Santos, L., additional, Ribeiro, S., additional, Pinto, F., additional, Nunes Diogo, A., additional, Kinova, E., additional, Zlatareva, N., additional, Goudev, A., additional, Bonanad, C., additional, Lopez-Lereu, M., additional, Monmeneu, J., additional, Bodi, V., additional, Sanchis, J., additional, Nunez, J., additional, Chaustre, F., additional, Llacer, A., additional, Ermacora, D., additional, Peluso, D., additional, Di Lazzari, M., additional, Meimoun, P., additional, Elmkies, F., additional, Benali, T., additional, Boulanger, J., additional, Zemir, H., additional, Clerc, J., additional, Luycx-Bore, A., additional, Velasco Del Castillo, M. S., additional, Cacicedo Fernandez De Bobadilla, A., additional, Onaindia Gandarias, J., additional, Telleria Arrieta, M., additional, Zugazabeitia Irazabal, G., additional, Quintana Raczka, O., additional, Rodriguez Sanchez, I., additional, Romero Pereiro, A., additional, Laraudogoitia Zaldumbide, E., additional, Lekuona Goya, I., additional, Bonello, B., additional, El Louali, E., additional, Fouilloux, V., additional, Kammache, I., additional, Ovaert, C., additional, Kreitmann, B., additional, Fraisse, A., additional, Migliore, R., additional, Adaniya, M., additional, Barranco, M., additional, Miramont, G., additional, Tamagusuku, H., additional, Alassar, A., additional, Sharma, R., additional, Marciniak, A., additional, Valencia, O., additional, Abdulkareem, N., additional, Jahangiri, M., additional, Jander, N., additional, Kienzle, R., additional, Gohlke-Baerwolf, C., additional, Gohlke, H., additional, Neumann, F.-J., additional, Minners, J., additional, Valbuena, S., additional, De Torres, F., additional, Lopez, T., additional, Gomez, J. J., additional, Guzman, G., additional, Dominguez, F., additional, Refoyo, E., additional, Moreno, M., additional, Lopez-Sendon, J. L., additional, Ancona, R., additional, Comenale Pinto, S., additional, Caso, P., additional, Di Salvo, G., additional, Severino, S., additional, Cavallaro, M., additional, Calabro, R., additional, Enache, R., additional, Piazza, R., additional, Roman-Pognuz, A., additional, Popescu, B., additional, Calin, A., additional, Beladan, C., additional, Purcarea, F., additional, Nicolosi, G., additional, Ginghina, C., additional, Savu, O., additional, Rosca, M., additional, Jurcut, R., additional, Serban, M., additional, Dorobantu, L., additional, Donal, E., additional, Mascle, S., additional, Thebault, C., additional, Veillard, D., additional, Hamonic, H., additional, Leguerrier, A., additional, Corbineau, H., additional, Popa, B. A., additional, Diena, M., additional, Bogdan, A., additional, Benea, D., additional, Lanzillo, G., additional, Casati, V., additional, Novelli, E., additional, Popa, A., additional, Cerin, G., additional, Gual Capllonch, F., additional, Teis, A., additional, Lopez Ayerbe, J., additional, Ferrer, E., additional, Vallejo, N., additional, Gomez Denia, E., additional, Bayes Genis, A., additional, Spethmann, S., additional, Schattke, S., additional, Baldenhofer, G., additional, Stangl, V., additional, Laule, M., additional, Baumann, G., additional, Stangl, K., additional, Knebel, F., additional, Labata, C., additional, Garcia Alonso, C., additional, Gual, F., additional, Nunez Aragon, R., additional, Sousa, C., additional, Vasile, A. I., additional, Dorobantu, M., additional, Iorgulescu, C., additional, Bogdan, S., additional, Constantinescu, D., additional, Caldararu, C., additional, Tautu, O., additional, Vatasescu, R., additional, Badran, H., additional, Elnoamany, M. F., additional, Ayad, M., additional, Elshereef, A., additional, Farhan, A., additional, Nassar, Y., additional, Yacoub, M., additional, Costabel, J., additional, Avegliano, G., additional, Elissamburu, P., additional, Thierer, J., additional, Castro, F., additional, Huguet, M., additional, Frangi, A., additional, Ronderos, R., additional, Prinz, C., additional, Van Buuren, F., additional, Faber, L., additional, Bitter, T., additional, Bogunovic, N., additional, Burchert, W., additional, Horstkotte, D., additional, Kasprzak, J. D., additional, Smialowski, A., additional, Rudzinski, T., additional, Lipiec, P., additional, Krzeminska-Pakula, M., additional, Wierzbowska-Drabik, K., additional, Trzos, E., additional, Kurpesa, M., additional, Motoki, H., additional, Hana, M., additional, Marwick, T., additional, Allan, K., additional, Vazquez-Alvarez, M., additional, Medrano Lopez, C., additional, Granja Da Silva, S., additional, Marcos, C., additional, Rodriguez-Ogando, A., additional, Alvarez, M., additional, Camino, M., additional, Centeno, M., additional, Maroto, E., additional, Feltes Guzman, G., additional, Serra Tomas, V., additional, Acevedo, O., additional, Calli, A., additional, Barba, M., additional, Pintos, G., additional, Valverde, V., additional, Zamorano Gomez, J., additional, Marchel, M., additional, Kochanowski, J., additional, Piatkowski, R., additional, Madej, A., additional, Filipiak, K., additional, Hausmanowa-Petrusewicz, I., additional, Opolski, G., additional, Malev, E., additional, Zemtsovsky, E., additional, Reeva, S., additional, Timofeev, E., additional, Pshepiy, A., additional, Mihaila, S., additional, Rimbas, R., additional, Mincu, R., additional, Dulgheru, R., additional, Mihaila, R., additional, Badiu, C., additional, Cinteza, M., additional, Vinereanu, D., additional, Lira, E., additional, Lebihan, D., additional, Monaco, C., additional, Ruiz Ortiz, M., additional, Mesa, D., additional, Delgado, M., additional, Romo, E., additional, Pena, M., additional, Puentes, M., additional, Santisteban, M., additional, Lopez Granados, A., additional, Arizon Del Prado, J., additional, Suarez De Lezo, J., additional, Tsai, W.-C., additional, Shih, J.-Y., additional, Huang, T.-S., additional, Liu, Y.-W., additional, Huang, Y.-Y., additional, Tsai, L.-M., additional, Cho, E., additional, Choi, K., additional, Kwon, B., additional, Kim, D., additional, Jang, S., additional, Park, C., additional, Jung, H., additional, Jeon, H., additional, Youn, H., additional, Kim, J., additional, Rieck, A. E., additional, Cramariuc, D., additional, Lonnebakken, M., additional, Lund, B., additional, Moceri, P., additional, Doyen, D., additional, Cerboni, P., additional, Ferrari, E., additional, Li, W., additional, Goncalves, S., additional, Vinhais De Sousa, G., additional, Almeida, A. G., additional, Hernandez Garcia, C., additional, De La Rosa Hernandez, A., additional, Arroyo Ucar, E., additional, Jorge Perez, P., additional, Barragan Acea, A., additional, Lacalzada Almeida, J., additional, Jimenez Rivera, J., additional, Duque Garcia, A., additional, Laynez Cerdena, I., additional, Arhipov, O., additional, Sumin, A. N., additional, Campens, L., additional, Renard, M., additional, Trachet, B., additional, Segers, P., additional, De Paepe, A., additional, De Backer, J., additional, Purvis, J. A., additional, Sharma, D., additional, Hughes, S. M., additional, Marek, D., additional, Vindis, D., additional, Kocianova, E., additional, Taborsky, M., additional, Yoon, H., additional, Kim, K., additional, Ahn, Y., additional, Chung, M., additional, Cho, J., additional, Kang, J., additional, Rha, W., additional, Ozcan, O., additional, Sezgin Ozcan, D., additional, Candemir, B., additional, Aras, M., additional, Dincer, I., additional, Atak, R., additional, Gianturco, L., additional, Turiel, M., additional, Atzeni, F., additional, Tomasoni, L., additional, Bruschi, E., additional, Epis, O., additional, Sarzi-Puttini, P., additional, Aggeli, C., additional, Poulidakis, E., additional, Felekos, I., additional, Sideris, S., additional, Dilaveris, P., additional, Gatzoulis, K., additional, Stefanadis, C., additional, Roszczyk, N., additional, Sobczak, M., additional, Peruga, J., additional, Krecki, R., additional, Kasprzak, J., additional, Ishii, K., additional, Suyama, T., additional, Kataoka, K., additional, Furukawa, A., additional, Nagai, T., additional, Maenaka, M., additional, Seino, Y., additional, Musca, F., additional, De Chiara, B., additional, Moreo, A., additional, Cataldo, S., additional, Parolini, M., additional, Parodi, O., additional, Bombardini, T., additional, Faita, F., additional, Park, S.-J., additional, Kil, J.-H., additional, Kim, S.-J., additional, Jang, S.-Y., additional, Chang, S.-A., additional, Choi, J.-O., additional, Lee, S.-C., additional, Park, S., additional, Park, P., additional, Oh, J., additional, Cikes, M., additional, Velagic, V., additional, Biocina, B., additional, Gasparovic, H., additional, Djuric, Z., additional, Bijnens, B., additional, Milicic, D., additional, Huqi, A., additional, Klas, B., additional, He, A., additional, Paterson, I., additional, Irween, M., additional, Ezekovitz, J., additional, Choy, J., additional, Chen, Y., additional, Cheng, L., additional, Yao, R., additional, Yao, H., additional, Chen, H., additional, Pan, C., additional, Shu, X., additional, Sobkowicz, B., additional, Kaminska, M., additional, Musial, W., additional, Buechel, R., additional, Sommer, G., additional, Leibundgut, G., additional, Rohner, A., additional, Bremerich, J., additional, Kaufmann, B., additional, Kessel-Schaefer, A., additional, Handke, M., additional, Kiotsekoglou, A., additional, Saha, S., additional, Toole, R., additional, Sharma, S., additional, Gopal, A., additional, Adhya, S., additional, Tsang, W., additional, Kenny, C., additional, Kapetanakis, S., additional, Lang, R., additional, Monaghan, M., additional, Smith, B., additional, Coulter, T., additional, Rendon, A., additional, Cheung, W.-S., additional, Gorissen, W., additional, Ejlersen, J. A., additional, May, O., additional, Van Slochteren, F. J., additional, Van Der Spoel, T., additional, Hanssen, H., additional, Doevendans, P., additional, Chamuleau, S., additional, De Korte, C., additional, Tarr, A., additional, Stoebe, S., additional, Trache, T., additional, Kluge, J.-G., additional, Varga, A., additional, Hagendorff, A., additional, Nagy, A., additional, Kovacs, A., additional, Apor, A., additional, Sax, B., additional, Becker, D., additional, Merkely, B., additional, Lindquist, R., additional, Miller, A., additional, Reece, C., additional, Eidem, B. W., additional, Choi, W.-G., additional, Kim, S., additional, Oh, S., additional, Kim, Y., additional, Iacobelli, R., additional, Chinali, M., additional, D' Asaro, M., additional, Toscano, A., additional, Del Pasqua, A., additional, Esposito, C., additional, Seghetti, G., additional, Parisi, F., additional, Pongiglione, G., additional, Rinelli, G., additional, Omaygenc, O., additional, Bakal, R., additional, Dogan, C., additional, Teber, K., additional, Akpinar, S., additional, Sahin, G., additional, Ozdemir, N., additional, Penhall, A., additional, Joseph, M., additional, Chong, F., additional, De Pasquale, C., additional, Selvanayagam, J., additional, Leong, D., additional, Nyktari, E. G., additional, Patrianakos, A. P., additional, Goudis, C., additional, Solidakis, G., additional, Parthenakis, F., additional, Vardas, P., additional, Nestaas, E., additional, Fugelseth, D., additional, Vitarelli, A., additional, Capotosto, L., additional, Bernardi, M., additional, Conde, Y., additional, Caranci, F., additional, Placanica, G., additional, Dettori, O., additional, Vitarelli, M., additional, De Chiara, S., additional, De Cicco, V., additional, Ferro', M., additional, Calabro', R., additional, Apostolakis, S., additional, Chalikias, G., additional, Tziakas, D., additional, Stakos, D., additional, Thomaidi, A., additional, Konstantinides, S., additional, Iorio, G., additional, Rucos, R., additional, Continanza, G., additional, D Ascanio, M., additional, Alessandroni, L., additional, Saponara, M., additional, Berry, M., additional, Nahum, J., additional, Zaghden, O., additional, Monin, J., additional, Couetil, J., additional, Lairez, O., additional, Macron, L., additional, Dubois Rande, J., additional, Gueret, P., additional, Lim, P., additional, Cameli, M., additional, Giacomin, E., additional, Lisi, M., additional, Benincasa, S., additional, Righini, F., additional, Menci, D., additional, Focardi, M., additional, Mondillo, S., additional, Philip, E., additional, Gorincour, G., additional, Bellsham-Revell, H., additional, Bell, A. J., additional, Miller, O. I., additional, Beerbaum, P., additional, Razavi, R., additional, Greil, G., additional, Simpson, J. M., additional, Ann, S., additional, Kim, T., additional, Lee, J., additional, Chin, J., additional, Cabeza Lainez, P., additional, Escolar Camas, V., additional, Gheorghe, L., additional, Fernandez Garcia, P., additional, Vazquez Garcia, R., additional, Caiulo, V., additional, Caiulo, S., additional, Fisicaro, A., additional, Moramarco, F., additional, Latini, G., additional, Seale, A., additional, Carvalho, J., additional, Gardiner, H., additional, Roughton, M., additional, Simpson, J., additional, Tometzki, A., additional, Uzun, O., additional, Webber, S., additional, Daubeney, P., additional, Dawood, A., additional, Dwivedi, G., additional, Mahadevan, G., additional, Jiminez, D., additional, Steeds, R., additional, Frenneaux, M., additional, Attenhofer Jost, C. H., additional, Knechtle, B., additional, Bernheim, A., additional, Pfyffer, M., additional, Linka, A., additional, Faeh-Gunz, A., additional, Seifert, B., additional, De Pasquale, G., additional, Zuber, M., additional, Tomaszewski, A., additional, Kutarski, A., additional, and Tomaszewski, M., additional

Published
2011
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25. Malnutrition & inflammation in CKD 1-5

Author

Gursu, M., primary, Aydin, Z., additional, Karadag, S., additional, Uzun, S., additional, Ogul, S., additional, Kiris, A., additional, Doventas, Y., additional, Koldas, M., additional, Ozturk, S., additional, Kazancioglu, R., additional, Mandreoli, M., additional, Bellasi, A., additional, Baldrati, L., additional, Corradini, M., additional, Rigotti, A., additional, Russo, G., additional, David, S., additional, Malmusi, G., additional, DiNicolo', P., additional, Orsi, C., additional, Zambianchi, L., additional, Caruso, F., additional, Poisetti, P., additional, Fabbri, A., additional, Santoro, A., additional, Barton Pai, A., additional, Grabe, D., additional, Eisele, G., additional, Hutchison, C. A., additional, Bevins, A., additional, Lukacik, P., additional, Hughes, R. G., additional, Pratt, G., additional, Viana, J. L., additional, Bishop, N. C., additional, Kosmadakis, G., additional, Bevington, A., additional, Clapp, E. L., additional, Feehally, J., additional, Smith, A. C., additional, Joki, N., additional, Hase, H., additional, Tanaka, Y., additional, Iwasaki, M., additional, Yamaka, T., additional, Shigematsu, T., additional, Dou, L., additional, Gondouin, B., additional, Cerini, C., additional, Duval-Sabatier, A., additional, Poitevin, S., additional, Dignat-George, F., additional, Burtey, S., additional, Brunet, P., additional, Carrasco, F., additional, Salvador, F., additional, Origaca, C., additional, Nogueira, E., additional, Silva, N., additional, Silva, A., additional, Sikole, A., additional, Trajceska, L., additional, Selim, G., additional, Gelev, S., additional, Dzekova, P., additional, Amitov, V., additional, Arsov, S., additional, Dalboni, M., additional, Cruz, E., additional, Manfredi, S., additional, Mouro, M., additional, Quinto, M., additional, Grabulosa, C., additional, Batista, M., additional, Cendoroglo, M., additional, Hirayama, A., additional, Matsui, H., additional, Nagano, Y., additional, Ueda, A., additional, Aoyagi, K., additional, Owada, S., additional, Schepers, E., additional, Barreto, D., additional, Liabeuf, S., additional, Glorieux, G., additional, Eloot, S., additional, Barreto, F., additional, Massy, Z., additional, Vanholder, R., additional, Secara, I. F., additional, Oleniuc, M., additional, Nistor, I., additional, Onofriescu, M., additional, Covic, A., additional, Aguerrevere, S., additional, Granada, M., additional, Bayes, B., additional, Pastor, M., additional, Sancho, A., additional, Bonal, J., additional, Canas, L., additional, Lauzurica, R., additional, Teixido, J., additional, Troya, M., additional, Romero, R., additional, Capitanini, A., additional, D'Alessandro, C., additional, Ferretti, V., additional, Petrone, I., additional, Pasquariello, G., additional, Cupisti, A., additional, Parastayeva, M. M., additional, Berseneva, O. N., additional, Kucher, A. G., additional, Ivanova, G. T., additional, Smirnov, A. V., additional, Kayukov, I. G., additional, Kayabasi, H., additional, Esmer, S., additional, Yilmaz, Z., additional, Kadiroglu, A. K., additional, Yilmaz, M. E., additional, Radic, J., additional, Kovacic, V., additional, Radic, M., additional, Ljutic, D., additional, Sain, M., additional, Karakan, S., additional, Sezer, S., additional, Tutal, E., additional, Ozdemir Acar, F. N., additional, Bi, G., additional, Xing, C., additional, Chen, R., additional, Romero-Garcia, A., additional, Jacobo-Arias, F., additional, Martin del Campo, F., additional, Gonzalez-Espinoza, L., additional, Pazarin, L., additional, Cueto-Manzano, A. M., additional, Panagoutsos, S., additional, Kriki, P., additional, Mourvati, E., additional, Tziakas, D., additional, Chalikias, G., additional, Stakos, D., additional, Apostolakis, S., additional, Tsigalou, C., additional, Gioka, T., additional, Konstantinides, S., additional, Vargemezis, V., additional, Nascimento, M., additional, Hayashi, S., additional, Seeberger, A., additional, Yamamoto, T., additional, Qureshi, A. R., additional, Lind, B., additional, Riella, M., additional, Brodin, L.-A., additional, Lindholm, B., additional, Meier, P., additional, Menne, J., additional, Kruger, K., additional, Mooren, F. C., additional, Weissmann, N., additional, Seimetz, M., additional, Haller, H., additional, Gusev, E., additional, Solomatina, L., additional, Zhuravleva, J., additional, Striker, G., additional, Uribarri, J., additional, Cai, W., additional, Goodman, S., additional, Pyzik, R., additional, Grosjean, F., additional, Vlassara, H., additional, So, A., additional, Gimona, A., additional, Kiechle, T., additional, Shpilsky, A., additional, and Schlesinger, N., additional

Published
2011
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27. Acute kidney injury - Human studies

Author

Locsey, L., primary, Seres, I., additional, Sztanek, F., additional, Harangi, M., additional, Padra, J., additional, Asztalos, L., additional, Paragh, G., additional, Hutchison, C. A., additional, Bevins, A., additional, Langham, R., additional, Mancini, E., additional, Wirta, O., additional, Cockwell, P., additional, Keir, R., additional, Vigano, M., additional, Stella, A., additional, Evans, N., additional, Chappell, M., additional, Fabbrini, P., additional, Onuigbo, M., additional, Onuigbo, N., additional, Kim, S., additional, Chang, J. H., additional, Jung, J. Y., additional, Lee, H. H., additional, Chung, W., additional, Zanoli, L., additional, Rastelli, S., additional, Marcantoni, C., additional, Tamburino, C., additional, Castellino, P., additional, Cho, A., additional, Choi, H., additional, Lee, J. E., additional, Jang, H. R., additional, Huh, W., additional, Kim, Y.-G., additional, Kim, D. J., additional, Oh, H. Y., additional, Garcia-Fernandez, N., additional, Martin-Moreno, P. L., additional, Varo, N., additional, Nunez-Cordoba, J. M., additional, Schlieper, G., additional, Kruger, T., additional, Kelm, M., additional, Floege, J., additional, Westenfeld, R., additional, Cho, A. J., additional, Doganay, S., additional, Oguz, A. K., additional, Ergun, I., additional, Bardachenko, N., additional, Kuryata, O., additional, Bardachenko, L., additional, Ravani, P., additional, Malberti, F., additional, Pirelli, S., additional, Scolari, F., additional, Barrett, B., additional, Presta, P., additional, Lucisano, G., additional, Rubino, A., additional, Serraino, F., additional, Amoruso, T., additional, Renzulli, A., additional, Fuiano, G., additional, Kielstein, J. T., additional, Tolk, S., additional, Heiden, A., additional, Kuhn, C., additional, Hoeper, M. M., additional, Lorenzen, J., additional, Broll, M., additional, Kaever, V., additional, Burhenne, H., additional, Hafer, C., additional, Haller, H., additional, Burkhardt, O., additional, Kielstein, J., additional, Zahalkova, J., additional, Petejova, N., additional, Strojil, J., additional, Urbanek, K., additional, Bertoli, S., additional, Musetti, C., additional, Cabiati, A., additional, Assanelli, E., additional, Lauri, G., additional, Marana, I., additional, De Metrio, M., additional, Rubino, M., additional, Campodonico, J., additional, Grazi, M., additional, Moltrasio, M., additional, Marenzi, G., additional, Unarokov, Z., additional, Mukhoedova, T., additional, Fidalgo, P., additional, Coelho, S., additional, Rodrigues, B., additional, Fernandes, A. P., additional, Papoila, A. L., additional, Liano, F., additional, Soto, K., additional, Vanmassenhove, J., additional, Vanholder, R., additional, Glorieux, G., additional, Van Biesen, W., additional, Challiner, R., additional, Ritchie, J., additional, Hutchison, A., additional, Zaharie, S. I., additional, Maria, D. T., additional, Zaharie, M., additional, Vaduva, C., additional, Grauntanu, C., additional, Cana-Ruiu, D., additional, Mota, E., additional, Hayer, M., additional, Baharani, J., additional, Thomas, M., additional, Eldehni, T., additional, Selby, N., additional, McIntyre, C., additional, Fluck, R., additional, Kolhe, N., additional, Fagugli, R. M., additional, Patera, F., additional, Shah, P. R., additional, Kaswan, K. K., additional, Kute, V. B., additional, Vanikar, A. V., additional, Gumber, M. R., additional, Patel, H. V., additional, Munjappa, B. C., additional, Enginner, D. P., additional, Sainaresh, V. V., additional, Trivedi, H. L., additional, Teixeira, C., additional, Nogueira, E., additional, Lopes, J. A., additional, Almeida, E., additional, Pais de Lacerda, A., additional, Gomes da Costa, A., additional, Franca, C., additional, Mariano, F., additional, Morselli, M., additional, Bergamo, D., additional, Hollo', Z., additional, Scella, S., additional, Maio, M., additional, Tetta, C., additional, Dellavalle, A., additional, Stella, M., additional, Triolo, G., additional, Cantaluppi, V., additional, Quercia, A. D., additional, Bertinetto, P., additional, Giacalone, S., additional, Tamagnone, M., additional, Basso, E., additional, Karvela, E., additional, Gai, M., additional, Leonardi, G., additional, Anania, P., additional, Guarena, C., additional, Fenocchio, C. M., additional, Pacitti, A., additional, Segoloni, G. P., additional, Kim, Y. O., additional, Kim, H. G., additional, Kim, B. S., additional, Song, H. C. S., additional, Min, J.-K., additional, Kim, S. Y., additional, Park, W. D., additional, Dalboni, M., additional, Narciso, R., additional, Quinto, M., additional, Grabulosa, C., additional, Cruz, E., additional, Monte, J., additional, Durao, M., additional, Cendoroglo, M., additional, Santos, O., additional, Batista, M., additional, Bellasi, A., additional, Giannone, S., additional, Mordenti, A., additional, Zanoni, A., additional, Santoro, A., additional, Lee, J. H., additional, Ha, S. H., additional, Kim, J. H., additional, Lee, G. J., additional, Jung, Y. C., additional, Malindretos, P., additional, Koutroumbas, G., additional, Patrinou, A., additional, Zagkotsis, G., additional, Makri, P., additional, Togousidis, I., additional, Syrganis, C., additional, Li Cavoli, G., additional, Tortorici, C., additional, Bono, L., additional, Ferrantelli, A., additional, Giammarresi, C., additional, Zagarrigo, C., additional, Rotolo, U., additional, Kim, H., additional, Jun, K., additional, Choi, W., additional, Krzesinski, J.-M., additional, Parotte, M.-C., additional, Vandevelde, C., additional, Keenan, J., additional, Dieterle, F., additional, Sultana, S., additional, Pinches, M., additional, Ciorciaro, C., additional, Schindler, R., additional, Schmitz, V., additional, Gautier, J.-C., additional, Benain, X., additional, Matchem, J., additional, Murray, P., additional, Adler, S., additional, Haase, M., additional, Haase-Fielitz, A., additional, Devarajan, P., additional, Bellomo, R., additional, Cruz, D. N., additional, Wagener, G., additional, Krawczeski, C. D., additional, Koyner, J. L., additional, Murray, P. T., additional, Zappitelli, M., additional, Goldstein, S., additional, Makris, K., additional, Ronco, C., additional, Martensson, J., additional, Martling, C.-R., additional, Venge, P., additional, Siew, E., additional, Ware, L. B., additional, Ikizler, A., additional, Mertens, P. R., additional, Lacquaniti, A., additional, Buemi, A., additional, Donato, V., additional, Lucisano, S., additional, Buemi, M., additional, Panagoutsos, S., additional, Kriki, P., additional, Mourvati, E., additional, Tziakas, D., additional, Chalikias, G., additional, Stakos, D., additional, Apostolakis, S., additional, Tsigalou, C., additional, Gioka, T., additional, Konstantinides, S., additional, Vargemezis, V., additional, Torregrosa, I., additional, Montoliu, C., additional, Urios, A., additional, Aguado, C., additional, Puchades, M. J., additional, Solis, M. A., additional, Juan, I., additional, Sanjuan, R., additional, Blasco, M., additional, Pineda, J., additional, Carratala, A., additional, Ramos, C., additional, Miguel, A., additional, Niculae, A., additional, Checherita, I. A., additional, Sandulovici, R., additional, David, C., additional, Ciocalteu, A., additional, Espinoza, M., additional, Hidalgo, J., additional, Lorca, E., additional, Santibanez, A., additional, Arancibia, F., additional, Gonzalez, F., additional, Park, M. Y., additional, Kim, E. J., additional, Choi, S. J., additional, Kim, J. K., additional, Hwang, S. D., additional, Lee, K.-h., additional, Seok, S.-J., additional, Yang, J.-O., additional, Lee, E.-Y., additional, Hong, S.-y., additional, Gil, H.-w., additional, Astapenko, E., additional, Shutov, A., additional, Savinova, G., additional, Rechnik, V., additional, Melo, M. J., additional, Raimundo, M., additional, Viegas, A., additional, Camara, I., additional, Antunes, F., additional, Kim, M.-J., additional, Kwon, S. H., additional, Lee, S. W., additional, Song, J. H., additional, and Lee, J. W., additional

Published
2011
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28. 532 NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN URINE CONCENTRATIONS MAY SERVE AS AN EARLY PROGNOSTIC MARKER FOR ACUTE KIDNEY INJURY IN MYOCARDIAL INFARCTION PATIENTS

Author

Tziakas, D., primary, Chalikias, G., additional, Tsigalou, C., additional, Apostolakis, S., additional, Stakos, D., additional, Thomaidi, A., additional, Mitrousi, K., additional, Kikas, P., additional, Kriki, P., additional, Gioka, T., additional, Panagoutsos, S., additional, Vargemezis, V., additional, and Konstantinides, S., additional

Published
2011
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30. Independent and additive prognostic ability of serum carboxy-terminal telopeptide of collagen type-I in heart failure patients: a multi-marker approach with high-negative predictive value to rule out long-term adverse events

Author

Tziakas, D. N., primary, Chalikias, G. K., additional, Stakos, D., additional, Chatzikyriakou, S. V., additional, Papazoglou, D., additional, Mitrousi, K., additional, Lantzouraki, A., additional, Thomaidi, A., additional, Boudoulas, H., additional, and Konstantinides, S., additional

Published
2011
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