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1. Health Literacy throughout adolescence: Invariance and validity study of three measurement scales in the general population

Author

Virginie Ringa, Laurent Rigal, Francis Guillemin, Christine Hassler, Alexandra Rouquette, Stephan Van den Broucke, Cécile Allaire, Sylvie Azogui-Levy, Julien Mancini, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Biostatistique et technologies de l'information et de la communication (BioSTIC) - [Hôpital de la Timone - APHM] (BiosTIC ), Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Université Catholique de Louvain = Catholic University of Louvain (UCL), Santé publique France - French National Public Health Agency [Saint-Maurice, France], Laboratoire Educations et Pratiques de Santé (LEPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Sorbonne Paris Nord, AP-HP. Université Paris Saclay, AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Adaptation, mesure et évaluation en santé. Approches interdisciplinaires (APEMAC), Université de Lorraine (UL), Centre d'investigation clinique - Epidémiologie clinique [Nancy] (CIC-EC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Laboratoire éducations et promotion de la santé (LEPS), Université Paris Cité – UFR Odontologie [Santé] (UPCité UFR Odontologie), Université Paris Cité (UPCité), HAL UVSQ, Équipe, UFR Odontologie [Santé] - Université Paris Cité (UFR Odontologie UPCité), Université Paris Cité – UFR Odontologie [Santé] (UPC UFR Odontologie), Université Paris Cité (UPC), Hôpital Bicêtre, Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM), and UCL - SSH/IPSY - Psychological Sciences Research Institute

Subjects
HLSAC, Adolescent, Psychometrics, [SDV]Life Sciences [q-bio], HAS-A, Population, 030209 endocrinology & metabolism, Health literacy, psychometric properties, Developmental psychology, HLS-EU-Q16, 03 medical and health sciences, 0302 clinical medicine, Surveys and Questionnaires, Humans, Measurement invariance, 030212 general & internal medicine, Child, education, Statistical hypothesis testing, education.field_of_study, 4. Education, Reproducibility of Results, General Medicine, Confirmatory factor analysis, Adolescence, [SDV] Life Sciences [q-bio], Psychometric properties, Health promotion, Convergent validity, Scale (social sciences), adolescence, Factor Analysis, Statistical, Psychology, health literacy
Abstract

International audience; Objective: To simultaneously investigate the psychometric properties of three recently developed health literacy measurement scales throughout adolescence in the general population. Methods: French versions of the Health Literacy for School-Aged Children (HLSAC, unidimensional) scale, the Health Literacy Assessment Scale for Adolescents (HAS-A, multidimensional) and the 16-item European Health Literacy Survey questionnaire (HLS-EU-Q16, unidimensional) were completed by 1 444 adolescents in 8th, 9th, 11th grade in general school and 11-12th grade in vocational school. Psychometric properties were studied using confirmatory factor analysis, McDonald's omega coefficient and hypothesis testing. Results: Structural validity was acceptable (HLS-EU-Q16) to good (HAS-A and HLSAC), no measurement invariance issue was found and internal consistency was acceptable for the three scales (0.68-0.84). Convergent validity was low (Pearson correlation coefficients < 0.5) and the only scale for which results were in agreement with a priori hypotheses was the HLSAC. Conclusions: Our results were supportive of the use of HLSAC to assess health literacy during adolescence but the HAS-A, with a slightly better structural validity, can also be promoted due to its three measured dimensions. Practice implications: The use of these scales in practice will help to focus on health literacy, a critical factor for prevention and health promotion in adolescence.

Published
2022
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2. Vasorin Plays a Critical Role in Vascular Smooth Muscle Cells and Arterial Functions

Author

Loïc Louvet, Gaëlle Lenglet, A. Michaela Krautzberger, Romuald Mentaverri, Frédéric Hague, Clara Kowalewski, Nassim Mahtal, Julie Lesieur, Anne‐Laure Bonnet, Caroline Andrique, Céline Gaucher, Cathy Gomila, Heinrich Schrewe, Pierre‐Louis Tharaux, Said Kamel, Catherine Chaussain, Isabelle Six, Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 (MABLab (ex-pmoi)), Université du Littoral Côte d'Opale (ULCO)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Laboratoire de Physiologie Cellulaire et Moléculaire - UR UPJV 4667 (LPCM), Université de Picardie Jules Verne (UPJV), Service d'Ingénierie Moléculaire pour la Santé (ex SIMOPRO) (SIMoS), Médicaments et Technologies pour la Santé (MTS), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Service de Chimie Bio-Organique et de Marquage (SCBM), Pathologies, imagerie et biothérapies oro-faciales = Orofacial pathologies, imaging and biotherapies (URP 2496), Université Paris Cité (UPCité), CHU Charles Foix [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), UFR Odontologie [Santé] - Université Paris Cité (UFR Odontologie UPCité), and Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Mice, Knockout, Physiology, Angiotensin II, Myocytes, Smooth Muscle, Clinical Biochemistry, Membrane Proteins, Cell Biology, Nitric Oxide, Muscle, Smooth, Vascular, Mice, Phenylephrine, Tamoxifen, Animals, Humans, Calcium, Carbachol, Apoptosis Regulatory Proteins, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; Within the cardiovascular system, the protein vasorin (Vasn) is predominantly expressed by vascular smooth muscle cells (VSMCs) in the coronary arteries and the aorta. Vasn knockout (Vasn(-/-) ) mice die within 3 weeks of birth. In the present study, we investigated the role of vascular Vasn expression on vascular function. We used inducible Vasn knockout mice (Vasn(CRE-ERT KO) and Vasn(SMMHC-CRE-ERT2 KO) , in which respectively all cells or SMCs only are targeted) to analyze the consequences of total or selective Vasn loss on vascular function. Furthermore, in vivo effects were investigated in vitro using human VSMCs. The death of Vasn(CRE-ERT KO) mice 21 days after tamoxifen injection was concomitant with decreases in blood pressure, angiotensin II levels, and vessel contractibility to phenylephrine. The Vasn(SMMHC-CRE-ERT2 KO) mice displayed concomitant changes in vessel contractibility in response to phenylephrine and angiotensin II levels. In vitro, VASN deficiency was associated with a shift toward the SMC contractile phenotype, an increase in basal intracellular Ca(2+) levels, and a decrease in the SMCs' ability to generate a calcium signal in response to carbachol or phenylephrine. Additionally, impaired endothelium-dependent relaxation (due to changes in nitric oxide signaling) was observed in all Vasn knockout mice models. Our present findings highlight the role played by Vasn SMC expression in the maintenance of vascular functions. The mechanistic experiments suggested that these effects are mediated by SMC phenotype switching and changes in intracellular calcium homeostasis, angiotensin II levels, and NO signaling.

Published
2022
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3. Periodontal and dental health in inflammatory bowel diseases: a systematic review

Author

Kevimy Agossa, Clara Yzet, Lidia Roman, Mathurin Fumery, Marjolaine Gosset, Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 (MBLC - ADDS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CHU Charles Foix [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), UFR Odontologie [Santé] - Université Paris Cité (UFR Odontologie UPCité), Université Paris Cité (UPCité), CHU Amiens-Picardie, Simplification des soins chez les patients complexes - UR UPJV 7518 (SSPC), Université de Picardie Jules Verne (UPJV), Périnatalité et Risques Toxiques - UMR INERIS_I 1 (PERITOX), and Institut National de l'Environnement Industriel et des Risques (INERIS)-Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie

Subjects
Periodontitis, medicine.medical_specialty, Crohn's disease, Hepatology, business.industry, dental, [SDV]Life Sciences [q-bio], Dental health, Gastroenterology, Disease, medicine.disease, Ulcerative colitis, Inflammatory bowel disease, stomatognathic diseases, stomatognathic system, Rheumatoid arthritis, Internal medicine, Medicine, Antibiotic prophylaxis, business, periodontal diseases, ulcerative colitis, caries
Abstract

International audience; Introduction: An increased risk of dental caries and periodontal diseases has been reported for inflammatory bowel disease (IBD) patients and are challenging conditions to manage. Areas covered: The authors searched international databases to find all studies assessing dental/periodontal outcomes in patients with IBD and other immune-mediated inflammatory disease (IMID), as well as the association between IMID medications and dental/periodontal status. Expert opinion: IBD are associated with a higher risk of both periodontitis and caries. Some evidence from rheumatoid arthritis suggests that periodontitis may be associated with a lower response to anti-TNF. There is no reliable evidence that IBD patients may be at greater risk of complications during routine dental care. On the basis of current data, guidelines can be proposed for the dental management focusing on the detection and eradication of infectious foci prior to the implementation of immunosuppressants/biologics and modified dental treatment protocol for invasive dental procedures that includes antibiotic prophylaxis.

Published
2021
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4. Influence of polymerization pressure and post-cure treatment on conversion degree and viscoelastic properties of polymer infiltrated ceramic network

Author

Laurence Jordan, Grégory Stoclet, Jean-François Nguyen, Benjamin Pomes, Stéphane Legoff, Pascal Béhin, Emmanuel Richaud, Laboratoire Procédés et Ingénierie en Mécanique et Matériaux (PIMM), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Centre National de la Recherche Scientifique (CNRS)-Arts et Métiers Sciences et Technologies, HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Université Paris Cité (UPCité), Unité de Recherche Biomatériaux Innovants et Interfaces (URB2i (URP_4462)), Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Institut de Recherche de Chimie Paris (IRCP), Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Ministère de la Culture (MC), Unité Matériaux et Transformations - UMR 8207 (UMET), Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), UFR Odontologie [Santé] - Université Paris Cité (UFR Odontologie UPCité), Dr Michael Sadoun (Majeb, Liege) is gratefully acknowledged for his help in PICN synthesis., Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM), Université de Paris (UP), Université de Paris (UP)-Université Sorbonne Paris Nord, Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Ministère de la Culture (MC), Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centrale Lille Institut (CLIL), and Université de Paris – UFR Odontologie Garancière [Santé] (UP UFR Odontologie G)

Subjects
Ceramics, Materials science, Matériaux [Sciences de l'ingénieur], Polymers, Surface Properties, Post cure, Polymer infiltrated ceramic network, Biomedical Engineering, High-pressure polymerization, 02 engineering and technology, Viscoelasticity, Polymerization, Degree (temperature), Biomaterials, 03 medical and health sciences, 0302 clinical medicine, Materials Testing, [SPI.MECA.MEMA]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Mechanics of materials [physics.class-ph], Composite material, [SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials, Post curing, Dynamic mechanical analysis, CAD/CAM blocks, Conversion degree, 030206 dentistry, 021001 nanoscience & nanotechnology, Mechanics of Materials, High pressure, Computer-Aided Design, 0210 nano-technology
Abstract

This study aimed at determining an optimum polymerization pressure for Polymer Infiltrated Ceramic Network (PICN) blocks by characterizing the conversion degree (DC) and the viscoelastic properties of experimental PICN blocks polymerized at 90 °C under various high pressures followed or not by post-cure treatment (PC). Near infrared analysis and dynamic mechanical analysis were used to characterize DC and viscoelastic properties of sixteen PICN: one control (thermo-cured) and fifteen experimental groups (one thermo-cured followed by PC and fourteen high pressure polymerized PICN, in the range of 50–350 MPa without and with PC). Conversion degree of high pressure polymerized PICN blocks without post curing displays an optimum between 100 and 150 MPa resulting in an improved E′ and Tg. Post curing induces a higher DC with a controversial effect on thermomechanical properties. The results suggested that 100–150 MPa without PC is an optimum polymerization parameter, resulting in PICN blocks with significantly better DC, Tg, E’. Dr Michael Sadoun (Majeb, Liege) is gratefully acknowledged for his help in PICN synthesis.

Published
2021
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5. Involvement of neural crest and paraxial mesoderm in oral mucosal development and healing

Author

Benjamin Fournier, Ali Nassif, Bruno Gogly, Christophe Klein, Ihsène Taïhi, Audrey Asselin, Juliane Isaac, Benoît Robert, Hélène Fohrer-Ting, Ariane Berdal, Centre de Recherche des Cordeliers (CRC), Université Paris Diderot - Paris 7 (UPD7)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Paris – UFR Odontologie Garancière [Santé] (UP UFR Odontologie G), Université de Paris (UP), Biologie Moléculaire du Développement, Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], Groupe Henri Mondor-Albert Chenevier, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Hôpital Albert Chenevier, Hôpital Rothschild [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Génétique Moléculaire de la Morphogénèse, This research was supported by The French National Research Agency (ANR) (Osteodiversity- project ANR-12-BSV1-0018), the foundation 'Foundation des Gueules Cassées' and the French Institute of Dental Research (IFRO)., We thank Dr. Yvan Lallemand, Dr. Glenda Comai, Pascal Dardenne of the Institut Pasteur, Dr. Amélie Coudert of the INSERM UMRS 1138 (Team Berdal), S Kerner for fruitful discussions on implant biology (Periodontal department, UFR Odontology, Paris Diderot University), the INSERM UMRS 1138 Light Imaging Core Facility (CICC) and the animal core facilities of Institut Pasteur and INSERM UMRS 1138 for their expert technical support. This study represents part of the dissertation of Ali Nassif's PhD degree at the University Paris-EST, Paris, France., Université Pierre et Marie Curie - Paris 6 (UPMC)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), UFR Odontologie [Santé] - Université Paris Cité (UFR Odontologie UPCité), Université Paris Cité (UPCité), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), CHU Rothschild [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université Paris Diderot - Paris 7 (UPD7)-École pratique des hautes études (EPHE)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), UFR Odontologie [UPD7], Université de Paris, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Henri Mondor-Hôpital Albert Chenevier, and Hôpital Rothschild

Subjects
0301 basic medicine, Pathology, [SDV]Life Sciences [q-bio], Cell Culture Techniques, Cell- and Tissue-Based Therapy, Gingiva, MESH: Fibroblasts/cytology, Transplants, Mesoderm, Mice, Neural crest, 0302 clinical medicine, Neural Stem Cells, MESH: Cell- and Tissue-Based Therapy/methods, Morphogenesis, MESH: Gingiva/cytology, MESH: Animals, Mouth mucosa, Skin, MESH: Mouth Mucosa/cytology, MESH: Fibroblasts/enzymology, MESH: Regeneration, MESH: Wound Healing/drug effects, Cell Differentiation, Cell tracking, MESH: Models, Animal, Mechanics of Materials, Models, Animal, Stem cell, Adult stem cell, MESH: Cell Differentiation, medicine.medical_specialty, Biophysics, Wound healing, Bioengineering, Biology, Biomaterials, 03 medical and health sciences, MESH: Mesoderm/metabolism, Paraxial mesoderm, medicine, MESH: Neural Stem Cells/metabolism, Animals, Humans, Regeneration, MESH: Mice, MESH: Cell Culture Techniques, MESH: Humans, MESH: Neural Crest/metabolism, Embryogenesis, 030206 dentistry, Fibroblasts, MESH: Transplants/metabolism, Embryonic stem cell, MESH: Morphogenesis, stomatognathic diseases, 030104 developmental biology, Multipotent Stem Cell, Multipotent stem cells, Ceramics and Composites, MESH: Mouth Mucosa/drug effects
Abstract

International audience; Tissue engineering therapies using adult stem cells derived from neural crest have sought accessible tissue sources of these cells because of their potential pluripotency. In this study, the gingiva and oral mucosa and their associated stem cells were investigated. Biopsies of these tissues produce neither scarring nor functional problems and are relatively painless, and fresh tissue can be obtained readily during different chairside dental procedures. However, the embryonic origin of these cells needs to be clarified, as does their evolution from the perinatal period to adulthood. In this study, the embryonic origin of gingival fibroblasts were determined, including gingival stem cells. To do this, transgenic mouse models were used to track neural crest derivatives as well as cells derived from paraxial mesoderm, spanning from embryogenesis to adulthood. These cells were compared with ones derived from abdominal dermis and facial dermis. Our results showed that gingival fibroblasts are derived from neural crest, and that paraxial mesoderm is involved in the vasculogenesis of oral tissues during development. Our in vitro studies revealed that the neuroectodermal origin of gingival fibroblasts (or gingival stem cells) endows them with multipotential properties as well as a specific migratory and contractile phenotype which may participate to the scar-free properties of the oral mucosa. Together, these results illustrate the high regenerative potential of neural crest-derived stem cells of the oral mucosa, including the gingiva, and strongly support their use in cell therapy to regenerate tissues with impaired healing.

Published
2018
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